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1. The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data

Author

d'Andrea, Giacomo, Pettorruso, Mauro, Di Lorenzo, Giorgio, Rhee, Taeho Greg, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Clerici, Massimo, Dell'Osso, Bernardo Maria, Sensi, Stefano L., Mansur, Rodrigo B., Rosenblat, Joshua D., Martinotti, Giovanni, and McIntyre, Roger S.

Published
2024
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2. Investigating the Effectiveness and Tolerability of Intranasal Esketamine Among Older Adults With Treatment-Resistant Depression (TRD): A Post-hoc Analysis from the REAL-ESK Study Group

Author

d'Andrea, Giacomo, Chiappini, Stefania, McIntyre, Roger S., Stefanelli, Giulia, Carullo, Rosalba, Andriola, Ileana, Zanardi, Raffaella, Martiadis, Vassilis, Sensi, Stefano L., Sani, Gabriele, Clerici, Massimo, Di Lorenzo, Giorgio, Vita, Antonio, Pettorruso, Mauro, and Martinotti, Giovanni

Published
2023
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3. Predicting outcome with Intranasal Esketamine treatment: A machine-learning, three-month study in Treatment-Resistant Depression (ESK-LEARNING)

Author

Pettorruso, Mauro, Guidotti, Roberto, d'Andrea, Giacomo, De Risio, Luisa, D'Andrea, Antea, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, De Filippis, Sergio, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Nicolò, Giuseppe, Martiadis, Vassilis, Bassetti, Roberta, Nucifora, Domenica, De Fazio, Pasquale, Rosenblat, Joshua D., Clerici, Massimo, Maria Dell'Osso, Bernardo, Vita, Antonio, Marzetti, Laura, Sensi, Stefano L., Di Lorenzo, Giorgio, McIntyre, Roger S., and Martinotti, Giovanni

Published
2023
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4. Evolution of antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia in the real-life: A 4-year follow-up naturalistic study

Author

Monteleone, Palmiero, Cascino, Giammarco, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Biondi, Massimo, Brasso, Claudio, Carpiniello, Bernardo, Collantoni, Enrico, Dell'Osso, Liliana, di Giannantonio, Massimo, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marcatili, Matteo, Marchesi, Carlo, Monteleone, Alessio Maria, Pompili, Maurizio, Roncone, Rita, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario

Published
2022
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6. One-year efficacy of a lifestyle behavioural intervention on physical and mental health in people with severe mental disorders: results from a randomized controlled trial.

Author

Luciano, M., Sampogna, G., D'Ambrosio, E., Rampino, A., Amore, M., Calcagno, P., Rossi, A., Rossi, R., Carmassi, C., Dell'Osso, L., Bianciardi, E., Siracusano, A., Della Rocca, Bianca, Di Vincenzo, M., Del Vecchio, Valeria, Malangone, Claudio, Mancuso, Emiliana, Toni, Claudia, Volpicelli, Antonio, and Andriola, Ileana

Subjects
MENTAL illness, PEOPLE with mental illness, RANDOMIZED controlled trials, MENTAL health, BODY mass index
Abstract

This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains. Patients were randomly allocated to receive the six-month experimental intervention (LIFESTYLE) or a behavioural control intervention. All enrolled patients were assessed at baseline and after one year. We recruited 401 patients (206 in the experimental and 195 in the control group) with a diagnosis of schizophrenia or other psychotic disorder (29.9%), bipolar disorder (43.3%), or major depression (26.9%). At one year, patients receiving the experimental intervention reported an improvement in body mass index, body weight, waist circumference, HOMA-IR index, anxiety and depressive symptoms and in quality of life. Our findings confirm the efficacy of the LIFESTYLE intervention in improving physical and mental health-related outcomes in patients with severe mental illnesses after one year. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data

Author

d'Andrea, Giacomo, primary, Pettorruso, Mauro, additional, Di Lorenzo, Giorgio, additional, Rhee, Taeho Greg, additional, Chiappini, Stefania, additional, Carullo, Rosalba, additional, Barlati, Stefano, additional, Zanardi, Raffaella, additional, Rosso, Gianluca, additional, Di Nicola, Marco, additional, Andriola, Ileana, additional, Marcatili, Matteo, additional, Clerici, Massimo, additional, Dell'Osso, Bernardo Maria, additional, Sensi, Stefano L., additional, Mansur, Rodrigo B., additional, Rosenblat, Joshua D., additional, Martinotti, Giovanni, additional, and McIntyre, Roger S., additional

Published
2023
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9. Disorganization and real-world functioning in schizophrenia: Results from the multicenter study of the Italian Network for Research on Psychoses

Author

Bracale, Nadja, Cardillo, Simona, Brasso, Claudio, Andriola, Ileana, Romano, Raffaella, Caforio, Grazia, Barlati, Stefano, Galluzzo, Alessandro, Deste, Giacomo, Pinna, Federica, Lostia di S. Sofia, Silvia, Lai, Alice, Signorelli, Maria Salvina, Corbo, Mariangela, Baroni, Gaia, Lupi, Matteo, Altamura, Mario, La Montagna, Maddalena, Malerba, Stefania, Murri, Martino Belvederi, Corso, Alessandro, Bugliani, Michele, Pizziconi, Giulia, Rossi, Rodolfo, Serrone, Dario, Giusti, Laura, Ussorio, Donatella, Salza, Anna, Merlotti, Eleonora, Piegari, Giuseppe, Patriarca, Sara, Pietrafesa, Daria, de Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Marangon, Debora, Grottaroli, Marika, Pigoni, Alessandro, Grassi, Silvia, Cremonese, Carla, Meneguzzo, Paolo, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Gesi, Camilla, Cremone, IvanMirko, Carpita, Barbara, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Di Fabio, Fabio, Buzzanca, Antonio, Girardi, Nicoletta, Niolu, Cinzia, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Rocca, P., Galderisi, S., Rossi, A., Bertolino, A., Rucci, P., Gibertoni, D., Montemagni, C., Bellino, S., Aguglia, E., Amore, M., Bellomo, A., Biondi, M., Carpiniello, B., Cuomo, A., D'Ambrosio, E., dell'Osso, L., Girardi, P., Marchesi, C., Monteleone, P., Montemitro, C., Oldani, L., Pacitti, F., Roncone, R., Siracusano, A., Tenconi, E., Vita, A., Zeppegno, P., Steardo, L., Jr, Vignapiano, A., and Maj, M.

Published
2018
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11. Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study

Author

Chiappini, Stefania, primary, d'Andrea, Giacomo, additional, De Filippis, Sergio, additional, Di Nicola, Marco, additional, Andriola, Ileana, additional, Bassetti, Roberta, additional, Barlati, Stefano, additional, Pettorruso, Mauro, additional, Sensi, Stefano, additional, Clerici, Massimo, additional, Dell'Osso, Bernardo, additional, Vita, Antonio, additional, and Martinotti, Giovanni, additional

Published
2023
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13. Nationwide consensus on the clinical management of treatment-resistant depression in Italy: a Delphi panel.

Author

Maina, Giuseppe, Adami, Marina, Ascione, Giuseppe, Bondi, Emi, De Berardis, Domenico, Delmonte, Dario, Maffezzoli, Silvia, Martinotti, Giovanni, Nivoli, Alessandra, Ottavianelli, Elena, Acciavatti, Tiziano, Albert, Umberto, Andreoli, Sara, Andriola, Ileana, Romanini, Fausto Antonielli, Bassetti, Roberta, Bettini, Francesca, Boi, Graziella, Cacciani, Paolo, and Calò, Paola

Subjects
THERAPEUTIC use of lithium, CONSENSUS (Social sciences), APPLICATION software, SOCIOECONOMIC factors, MENTAL depression, KETAMINE, RESEARCH funding, QUESTIONNAIRES, SCALE analysis (Psychology), DECISION making, MEDICAL practice, DATA analysis software, DELPHI method, WORLD Wide Web, ANTIPSYCHOTIC agents, OUTPATIENT services in hospitals
Abstract

Background: Treatment-resistant depression (TRD) is defined by the European Medicines Agency as a lack of clinically meaningful improvement after treatment, with at least two different antidepressants. Individual, familiar, and socio-economic burden of TRD is huge. Given the lack of clear guidelines, the large variability of TRD approaches across different countries and the availability of new medications to meet the need of effective and rapid acting therapeutic strategies, it is important to understand the consensus regarding the clinical characteristics and treatment pathways of patients with TRD in Italian routine clinical practice, particularly in view of the recent availability of esketamine nasal spray. Methods: A Delphi questionnaire with 17 statements (with a 7 points Likert scale for agreement) was administered via a customized web-based platform to Italian psychiatrists with at least 5 years of experience and specific expertise in the field of depression. In the second-round physicians were asked to answer the same statements considering the interquartile range of each question as an index of their colleagues' responses. Stata 16.1 software was used for the analyses. Results: Sixty panellists, representative of the Italian territory, answered the questionnaire at the first round. For 8/17 statements more than 75% of panellists reached agreement and a high consensus as they assigned similar scores; for 4 statements the panellists assigned similar scores but in the middle of the Likert scale showing a moderate agreement with the statement, while for 5 statements there was indecision in the agreement and low consensus with the statement. Conclusions: This Delphi Panel showed that there is a wide heterogeneity in Italy in the management of TRD patients, and a compelling need of standardised strategies and treatments specifically approved for TRD. A high level of consensus and agreement was obtained about the importance of adding lithium and/or antipsychotics as augmentation therapies and in the meantime about the need for long-term maintenance therapy. A high level of consensus and agreement was equally reached for the identification of esketamine nasal spray as the best option for TRD patients and for the possibility to administrate without difficulties esketamine in a community outpatient setting, highlighting the benefit of an appropriate educational support for patients. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Does social cognition change? Evidence after 4 years from the Italian Network for Research on Psychoses

Author

Rocca, Paola, Rucci, Paola, Montemagni, Cristiana, Rossi, Alessandro, Bertolino, Alessandro, Aguglia, Eugenio, Altamura, Carlo A, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Brasso, Claudio, Carpiniello, Bernardo, Del Favero, Elisa, Dell'Osso, Liliana, Di Fabio, Fabio, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marchesi, Carlo, Martinotti, Giovanni, Monteleone, Palmiero, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, Maj, Mario, Silvio, Bellino, Paola, Bozzatello, Vincenzo, Villari, Pierluigi, Selvaggi, Enrico, D’Ambrosio, Linda, Antonucci, Stefano, Barlati, Giacomo, Deste, Gabriele, Nibbio, Federica, Pinna, Benedetta, Olivieri, Daniela, Manca, Carmen, Concerto, Laura, Fusar Poli, Alessandro, Rodolico, Mauro, Pettorruso, Giacomo, D’Andrea, Alessio, Mosca, Mario, Altamura, Fiammetta, Gallone, Laura, De Masi, Pietro, Calcagno, Valeria, Placenti, Alice, Trabucco, Valeria, Bianchini, Laura, Giusti, Silvia, Mammarella, Arianna, Di Berardo, Ramona, di Stefano, Matteo, Marcatili, Valentina, Ciappolino, Luisa, Belloni, Paola, Bucci, Giuseppe, Piegari, Luigi, Giuliani, Francesco, Brando, Carla, Gramaglia, Eleonora, Gambaro, Pierluigi, Prosperini, Angela, Favaro, Enrico, Collantoni, Paolo, Meneguzzo, Matteo, Tonna, Paolo, Ossola, Maria Lidia, Gerra, Claudia, Carmassi, Virginia, Pedrinelli, Barbara, Carpita, Cascino, Giammarco, Giulio, Corrivetti, Gianfranco, Del Buono, Tommaso, Accinni, Antonino, Buzzanca, Marianna, Frascarelli, Anna, Comparelli, Roberto, Brugnoli, Isabella, Berardelli, Simone, Bolognesi, Alessandro, Cuomo, Arianna, Goracci, Giorgio, Di Lorenzo, Cinzia, Niolu, Michele, Ribolsi., Rocca, Paola, Rucci, Paola, Montemagni, Cristiana, Rossi, Alessandro, Bertolino, Alessandro, Aguglia, Eugenio, Altamura, Carlo A, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Brasso, Claudio, Carpiniello, Bernardo, Del Favero, Elisa, Dell'Osso, Liliana, Di Fabio, Fabio, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marchesi, Carlo, Martinotti, Giovanni, Monteleone, Palmiero, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario

Subjects
schizophrenia, Psychiatry and Mental health, recovery, Follow-up, reliable and clinically significant change (RCSC), social cognition, theory of mind
Abstract

Background Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up. Methods The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up. Results In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery. Conclusions The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.

Published
2023

15. Real-world experience of esketamine use to manage treatment-resistant depression: A multicentric study on safety and effectiveness (REAL-ESK study)

Author

Martinotti, Giovanni, primary, Vita, Antonio, additional, Fagiolini, Andrea, additional, Maina, Giuseppe, additional, Bertolino, Alessandro, additional, Dell'Osso, Bernardo, additional, Siracusano, Alberto, additional, Clerici, Massimo, additional, Bellomo, Antonello, additional, Sani, Gabriele, additional, d'Andrea, Giacomo, additional, Chiaie, Roberto Delle, additional, Conca, Andreas, additional, Barlati, Stefano, additional, Di Lorenzo, Giorgio, additional, De Fazio, Pasquale, additional, De Filippis, Sergio, additional, Nicolò, Giuseppe, additional, Rosso, Gianluca, additional, Valchera, Alessandro, additional, Nucifora, Domenica, additional, Di Mauro, Stefania, additional, Bassetti, Roberta, additional, Martiadis, Vassilis, additional, Olivola, Miriam, additional, Belletti, Sandro, additional, Andriola, Ileana, additional, Di Nicola, Marco, additional, Pettorruso, Mauro, additional, McIntyre, Roger S., additional, and di Giannantonio, Massimo, additional

Published
2022
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16. The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study

Author

Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Biondi, Massimo, Callista, Gaetano, Comparelli, Anna, Dell’Osso, Liliana, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Niolu, Cinzia, Piegari, Giuseppe, Pinna, Federica, Roncone, Rita, Stratta, Paolo, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Mancini, Marina, Nettis, Maria Antonietta, Rizzo, Giuseppe, Porcelli, Stefano, Deste, Giacomo, Galluzzo, Alessandro, Gheda, Luca, Carpiniello, Bernardo, Ghiani, Alice, Lai, Alice, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria Salvina, Acciavatti, Tiziano, Alessandrini, Marco, Vellante, Federica, Cantisani, Andrea, Altamura, Mario, Padalino, Flavia A., Pagano, Tiziana, Belvedere Murri, Martino, Calcagno, Pietro, Corso, Alessandro, D’Onofrio, Simona, Marucci, Carmela, Santarelli, Valeria, Bianchini, Valeria, Giusti, Laura, Malavolta, Maurizio, Bucci, Paola, Chieffi, Marcello, De Simone, Stefania, Merlotti, Eleonora, Rocco, Mariangela, Vignapiano, Annarita, Tomasetti, Carmine, Feggi, Alessandro, Gattoni, Eleonora, Gramaglia, Carla, Cremonese, Carla, Collantoni, Enrico, Gallicchio, Davide, De Panfilis, Chiara, Ossola, Paolo, Tonna, Matteo, Carmassi, Claudia, Gesi, Camilla, Rutigliano, Grazia, Brugnoli, Roberto, Corigliano, Valentina, De Carolis, Antonella, Di Fabio, Fabio, Mirigliani Torti, Alessia Maria Chiara, Di Lorenzo, Giorgio, Siracusano, Alberto, Troisi, Alfonso, Bartoli, Luca, Corrivetti, Giulio, Diasco, Ferdinando, Bolognesi, Simone, Borghini, Elisa, Goracci, Arianna, Frieri, Tiziana, Mingrone, Cinzia, Sigaudo, Monica, and Italian Network for Research on Psychoses

Published
2017
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17. Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment‐resistant depression.

Author

Martinotti, Giovanni, Dell'Osso, Bernardo, Di Lorenzo, Giorgio, Maina, Giuseppe, Bertolino, Alessandro, Clerici, Massimo, Barlati, Stefano, Rosso, Gianluca, Di Nicola, Marco, Marcatili, Matteo, d'Andrea, Giacomo, Cavallotto, Clara, Chiappini, Stefania, De Filippis, Sergio, Nicolò, Giuseppe, De Fazio, Pasquale, Andriola, Ileana, Zanardi, Raffaella, Nucifora, Domenica, and Di Mauro, Stefania

Subjects
MENTAL depression, BIPOLAR disorder, HYPOMANIA, AFFECTIVE disorders, INTRANASAL medication, DISEASE duration
Abstract

Background: Bipolar depression accounts for most of the disease duration in type I and type II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals do not respond to first‐line therapeutic options, resulting in treatment‐resistant bipolar depression (B‐TRD). Esketamine, the S‐enantiomer of ketamine, has recently been approved for treatment‐resistant depression (TRD), but no data are available on its use in B‐TRD. Objectives: To compare the efficacy of esketamine in two samples of unipolar and bipolar TRD, providing preliminary indications of its effectiveness in B‐TRD. Secondary outcomes included the evaluation of the safety and tolerability of esketamine in B‐TRD, focusing on the average risk of an affective switch. Methods: Thirty‐five B‐TRD subjects treated with esketamine nasal spray were enrolled and compared with 35 TRD patients. Anamnestic data and psychometric assessments (Montgomery‐Asberg Depression Rating Scale/MADRS, Hamilton‐depression scale/HAM‐D, Hamilton‐anxiety scale/HAM‐A) were collected at baseline (T0), at one month (T1), and three months (T2) follow up. Results: A significant reduction in depressive symptoms was found at T1 and T2 compared to T0, with no significant differences in response or remission rates between subjects with B‐TRD and TRD. Esketamine showed a greater anxiolytic action in subjects with B‐TRD than in those with TRD. Improvement in depressive symptoms was not associated with treatment‐emergent affective switch. Conclusions: Our results supported the effectiveness and tolerability of esketamine in a real‐world population of subjects with B‐TRD. The low risk of manic switch in B‐TRD patients confirmed the safety of this treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Using combined environmental-clinical classification models to predict role functioning outcome in clinical high-risk states for psychosis and recent-onset depression

Author

Antonucci, Linda A., Penzel, Nora, Sanfelici, Rachele, Pigoni, Alessandro, Kambeitz-Ilankovic, Lana, Dwyer, Dominic, Ruef, Anne, Sen Dong, Mark, Ozturk, Omer Faruk, Chisholm, Katharine, Haidl, Theresa, Rosen, Marlene, Ferro, Adele, Pergola, Giulio, Andriola, Ileana, Blasi, Giuseppe, Ruhrmann, Stephan, Schultze-Lutter, Frauke, Falkai, Peter, Kambeitz, Joseph, Lencer, Rebekka, Dannlowski, Udo, Upthegrove, Rachel, Salokangas, Raimo K. R., Pantelis, Christos, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Bertolino, Alessandro, Koutsouleris, Nikolaos, Antonucci, Linda A., Penzel, Nora, Sanfelici, Rachele, Pigoni, Alessandro, Kambeitz-Ilankovic, Lana, Dwyer, Dominic, Ruef, Anne, Sen Dong, Mark, Ozturk, Omer Faruk, Chisholm, Katharine, Haidl, Theresa, Rosen, Marlene, Ferro, Adele, Pergola, Giulio, Andriola, Ileana, Blasi, Giuseppe, Ruhrmann, Stephan, Schultze-Lutter, Frauke, Falkai, Peter, Kambeitz, Joseph, Lencer, Rebekka, Dannlowski, Udo, Upthegrove, Rachel, Salokangas, Raimo K. R., Pantelis, Christos, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Bertolino, Alessandro, and Koutsouleris, Nikolaos

Abstract

Background Clinical high-risk states for psychosis (CHR) are associated with functional impairments and depressive disorders. A previous PRONIA study predicted social functioning in CHR and recent-onset depression (ROD) based on structural magnetic resonance imaging (sMRI) and clinical data. However, the combination of these domains did not lead to accurate role functioning prediction, calling for the investigation of additional risk dimensions. Role functioning may be more strongly associated with environmental adverse events than social functioning. Aims We aimed to predict role functioning in CHR, ROD and transdiagnostically, by adding environmental adverse events-related variables to clinical and sMRI data domains within the PRONIA sample. Method Baseline clinical, environmental and sMRI data collected in 92 CHR and 95 ROD samples were trained to predict lower versus higher follow-up role functioning, using support vector classification and mixed k-fold/leave-site-out cross-validation. We built separate predictions for each domain, created multimodal predictions and validated them in independent cohorts (74 CHR, 66 ROD). Results Models combining clinical and environmental data predicted role outcome in discovery and replication samples of CHR (balanced accuracies: 65.4% and 67.7%, respectively), ROD (balanced accuracies: 58.9% and 62.5%, respectively), and transdiagnostically (balanced accuracies: 62.4% and 68.2%, respectively). The most reliable environmental features for role outcome prediction were adult environmental adjustment, childhood trauma in CHR and childhood environmental adjustment in ROD. Conclusions Findings support the hypothesis that environmental variables inform role outcome prediction, highlight the existence of both transdiagnostic and syndrome-specific predictive environmental adverse events, and emphasise the importance of implementing real-world models by measuring multiple risk dimensions.

Published
2022

19. Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited

Author

Koutsouleris, Nikolaos, Pantelis, Christos, Kambeitz, Joseph, Toivonen, Anna, Turtonen, Otto, Botterweck, Sonja, Kluthausen, Norman, Antoch, Gerald, Caspers, Julian, Wittsack, Hans-Jörg, Blasi, Giuseppe, Pergola, Giulio, Caforio, Grazia, Salokangas, Raimo K R, Fazio, Leonardo, Quarto, Tiziana, Gelao, Barbara, Romano, Raffaella, Andriola, Ileana, Falsetti, Andrea, Barone, Marina, Passiatore, Roberta, Sangiuliano, Marina, Surmann, Marian, Hietala, Jarmo, Bienek, Olga, Dannlowski, Udo, Solana, Ana Beatriz, Abraham, Manuela, Schirmer, Timo, Ferro, Adele, Re, Marta, Sberna, Maurizio, D'Agostino, Armando, Del Fabro, Lorenzo, Bertolino, Alessandro, Perna, Giampaolo, Nobile, Maria, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Delvecchio, Giuseppe, Maggioni, Eleonora, Squarcina, Letizia, Gritti, Davide, Brambilla, Paolo, Rossetti, Maria Gloria, Ferrari, Raffaele, Hernandez, Dena Michelle Godwin, Nalls, Michael, Rohrer, Jonathan, Ramasamy, Adaikalavan, Kwok, John, Dobson-Stone, Carol, Brooks, William, Schofield, Peter, Upthegrove, Rachel, Halliday, Glenda, Hodges, John, Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Wood, Stephen J, Cruchaga, Carlos, Cairns, Nigel, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Albani, Diego, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Lencer, Rebekka, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Landqvist Waldö, Maria, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek, Mann, David, Borgwardt, Stefan, Grafman, Jordan, Morris, Christopher, Attems, Johannes, McKeith, Ian, Thomas, Alan, Pietrini, Pietro, Huey, Edward, Wassermann, Eric, Baborie, Atik, Jaros, Evelyn, Maj, Carlo, Tierney, Michael, Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Velakoulis, Dennis, Nöthen, Markus M., Pinessi, Lorenzo, Rogaeva, Ekaterina, George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James, Schlachetzki, Johannes, Uphill, James, Collinge, John, Degenhardt, Franziska, Mead, Simon, Van Deerlin, Vivianna, Marschhauser, Anke, Regenbrecht, Frank, Thoene-Otto, Angelika, Gordulla, Jannis, Ballarini, Tommaso, Engel, Annerose, Pino, Daniele, Leuthold, Dominique, Polyakova, Maryna, Naumann, Heike, Grossman, Murray, Trojanowski, John Q, van der Zee, Julie, Van Broeckhofen, Christine, Cappa, Stefano F, Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Mueller, Karsten, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E, Hjermind, Lena E, Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Villringer, Arno, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N, Fox, Nick C, Warren, Jason D, Spillantini, Maria Grazia, Morris, Huw R, Rizzu, Patrizia, Heutink, Peter, Danek, Adrian, Snowden, Julie S, Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C, Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Fassbender, Klaus, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W, Graff-Radford, Neill R, Petersen, Ronald C, Knopman, David S, Josephs, Keith A, Fliessbach, Klaus, Boeve, Bradley F, Parisi, Joseph E, Seeley, William W, Miller, Bruce L, Karydas, Anna M, Rosen, Howard, van Swieten, John C, Dopper, Elise Gp, Seelaar, Harro, Pijnenburg, Yolande Al, Jahn, Holger, Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A, Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Kornhuber, Johannes, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebouvier, Thibaud, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B, McGuire, Philip, Landwehrmeyer, Bernhard, Hardy, John, Momeni, Parastoo, Barthel, Henryk, Elisa, Semler, Jolina, Lombardi, Christine, von Arnim, Felix, Oberahauser, Kai, Schumacher, Jan, Lehmbeck, Juan-Manuel, Maler, Anderl-Straub, Sarah, Tanja, Richter-Schmidinger, Anke, Hammer-Kaspereit, Timo, Oberstein, Felix, Müller-Sarnowski, Carola, Roßmeier, Albert, Ludolph, Jan, Kassubek, Anja, Schneider, Johannes, Levin, Prudlo, Johannes, Synofzik, Matthis, Wiltfang, Jens, Riedl, Lina, Diehl-Schmid, Janine, Otto, Markus, Meisenzahl, Eva, Falkai, Peter, Dwyer, Dominic B, Schroeter, Matthias L, Consortium, the PRONIA, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Yanis, Urquijo-Castro, Maria-Fernanda, Öztürk, Ömer, Penzel, Nora, Rangnick, Adrian, von Saldern, Sebastian, Spangemacher, Moritz, Tupac, Ana, Weiske, Johanna, Wosgien, Antonia, Krämer, Camilla, Blume, Karsten, Paul, Riya, Hedderich, Dennis, Julkowski, Dominika, Kaiser, Nathalie, Lichtenstein, Thorsten, Milz, Ruth, Nikolaides, Alexandra, Pilgram, Tanja, Seves, Mauro, Wassen, Martina, Andreou, Christina, Dong, Sen, Egloff, Laura, Harrisberger, Fabienne, Heitz, Ulrike, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Popovic, David, Day, Chris, Lowri Griffiths, Sian, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Lalousis, Paris, Denissoff, Alexander, Ellilä, Anu, Oeztuerk, Oemer, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Säilä, Reetta-Liina, International FTD-Genetics Consortium (IFGC), German Frontotemporal Lobar Degeneration (FTLD) Consortium, PRONIA Consortium, and International FTD-Genetics Consortium Consortium

Subjects
Adult, Male, Medizin, genetics [Alzheimer Disease], genetics [Psychotic Disorders], Neuropsychological Tests, diagnostic imaging [Frontotemporal Dementia], diagnostic imaging [Psychotic Disorders], Machine Learning, methods [Magnetic Resonance Imaging], Brain, Female, Humans, Magnetic Resonance Imaging, Alzheimer Disease, Frontotemporal Dementia, Psychotic Disorders, Schizophrenia, pathology [Brain], genetics [Schizophrenia], ddc:610, diagnostic imaging [Brain], genetics [Frontotemporal Dementia], Settore MED/25 - Psichiatria, Psychiatry and Mental health, diagnostic imaging [Schizophrenia], diagnostic imaging [Alzheimer Disease]
Abstract

Weitere Nicht-UDE Autoren sind nicht genannt. Importance: The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, and their relevance for patients in at-risk disease stages has not been explored so far. Objective: To use machine learning to compare the expression of structural magnetic resonance imaging (MRI) patterns of behavioral-variant frontotemporal dementia (bvFTD), Alzheimer disease (AD), and schizophrenia; estimate predictability in patients with bvFTD and schizophrenia based on sociodemographic, clinical, and biological data; and examine prognostic value, genetic underpinnings, and progression in patients with clinical high-risk (CHR) states for psychosis or recent-onset depression (ROD). Design, Setting, and Participants: This study included 1870 individuals from 5 cohorts, including (1) patients with bvFTD (n = 108), established AD (n = 44), mild cognitive impairment or early-stage AD (n = 96), schizophrenia (n = 157), or major depression (n = 102) to derive and compare diagnostic patterns and (2) patients with CHR (n = 160) or ROD (n = 161) to test patterns' prognostic relevance and progression. Healthy individuals (n = 1042) were used for age-related and cohort-related data calibration. Data were collected from January 1996 to July 2019 and analyzed between April 2020 and April 2022. Main Outcomes and Measures: Case assignments based on diagnostic patterns; sociodemographic, clinical, and biological data; 2-year functional outcomes and genetic separability of patients with CHR and ROD with high vs low pattern expression; and pattern progression from baseline to follow-up MRI scans in patients with nonrecovery vs preserved recovery. Results: Of 1870 included patients, 902 (48.2%) were female, and the mean (SD) age was 38.0 (19.3) years. The bvFTD pattern comprising prefrontal, insular, and limbic volume reductions was more expressed in patients with schizophrenia (65 of 157 [41.2%]) and major depression (22 of 102 [21.6%]) than the temporo-limbic AD patterns (28 of 157 [17.8%] and 3 of 102 [2.9%], respectively). bvFTD expression was predicted by high body mass index, psychomotor slowing, affective disinhibition, and paranoid ideation (R2= 0.11). The schizophrenia pattern was expressed in 92 of 108 patients (85.5%) with bvFTD and was linked to the C9orf72 variant, oligoclonal banding in the cerebrospinal fluid, cognitive impairment, and younger age (R2= 0.29). bvFTD and schizophrenia pattern expressions forecasted 2-year psychosocial impairments in patients with CHR and were predicted by polygenic risk scores for frontotemporal dementia, AD, and schizophrenia. Findings were not associated with AD or accelerated brain aging. Finally, 1-year bvFTD/schizophrenia pattern progression distinguished patients with nonrecovery from those with preserved recovery. Conclusions and Relevance: Neurobiological links may exist between bvFTD and psychosis focusing on prefrontal and salience system alterations. Further transdiagnostic investigations are needed to identify shared pathophysiological processes underlying the neuroanatomical interface between the 2 disease spectra.

Published
2022

20. Clinical, brain, and multilevel clustering in early psychosis and affective stages

Author

Dwyer, Dominic B., Buciuman, Madalina-Octavia, Ruef, Anne, Kambeitz, Joseph, Sen Dong, Mark, Stinson, Caedyn, Kambeitz-Ilankovic, Lana, Degenhardt, Franziska, Sanfelici, Rachele, Antonucci, Linda A., Lalousis, Paris Alexandros, Wenzel, Julian, Urquijo-Castro, Maria Fernanda, Popovic, David, Oeztuerk, Oemer Faruk, Haas, Shalaila S., Weiske, Johanna, Hauke, Daniel, Neufang, Susanne, Schmidt-Kraepelin, Christian, Ruhrmann, Stephan, Penzel, Nora, Lichtenstein, Theresa, Rosen, Marlene, Chisholm, Katharine, Riecher-Rössler, Anita, Egloff, Laura, Schmidt, André, Andreou, Christina, Hietala, Jarmo, Schirmer, Timo, Romer, Georg, Michel, Chantal, Rössler, Wulf, Maj, Carlo, Borisov, Oleg, Krawitz, Peter M., Falkai, Peter, Pantelis, Christos, Lencer, Rebekka, Bertolino, Alessandro, Borgwardt, Stefan, Noethen, Markus, Brambilla, Paolo, Schultze-Lutter, Frauke, Meisenzahl, Eva, Wood, Stephen J., Davatzikos, Christos, Upthegrove, Rachel, Salokangas, Raimo K. R., Koutsouleris, Nikolaos, Mackintosh, Amatya, Kaiser, Nathalie, Lichtenstein, Thorsten, Seves, Mauro, Chisholm, Katie, Reniers, Renate, Stainton, Alexandra, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Tuominen, Lauri, Luutonen, Sinikka, Paju, Janina, Tikka, Maria, Armio (Säilä), Reetta-Liina, Toivonen, Anna, Walta, Maija, Fabbro, Franco, Balestrieri, Matteo, Bonivento, Carolina, Garzitto, Marco, Cabras, Giuseppe, Piccin, Sara, Castellani, Umberto, Bellani, Marcella, Maieron, Marta, Girometti, Rossano, Zuiani, Chiara, Skafidas, Stan, Velakoulis, Dennis, Everall, Ian, Merritt, Antonia, Jovicevic, Michael, Plicht, Manuel, Bequé, Dirk, Solana Sánchez, Ana Beatriz, Hehn, Nicolas, Herrmann, Katrin, Burke, Michael X., Fernandez, Brice, Altamura, Carlo, Rango, Mario, Ferro, Adele, Belleri, Marika, Maggioni, Eleonora, Squarcina, Letizia, Re, Marta, Delvecchio, Giuseppe, Meneghelli, Anna, Monzani, Emiliano, Sassi, Roberto, Sberna, Maurizio, Gennari, Luciana, Torremante, Patrizia, Surmann, Marian, Dannlowski, Udo, Bienek, Olga, Blasi, Giuseppe, Pergola, Giulio, Quarto, Tiziana, Andriola, Ileana, Romano, Raffaella, Gelao, Barbara, Fazio, Leonardo, Korda, Alexandra, Rohner, Henrik, Mann, Matthias, Geyer, Phillip, Treit, Peter, Müller, Johannes, Frackowiak, Richard, Wasserman, Danuta, Maier, Wolfgang, Binder, Elisabeth, Woopen, Christiane, Spranger, Tade Matthias, Möhrmann, Karl-Heinz, and PRONIA Consortium

Subjects
Adult, Male, Psychiatry and Mental health, Psychotic Disorders, Schizophrenia, Medizin, Brain, Cluster Analysis, Humans, Female, Longitudinal Studies, 610 Medizin und Gesundheit, Original Investigation
Abstract

Importance Approaches are needed to stratify individuals in early psychosis stages beyond positive symptom severity to investigate specificity related to affective and normative variation and to validate solutions with premorbid, longitudinal, and genetic risk measures. Objective To use machine learning techniques to cluster, compare, and combine subgroup solutions using clinical and brain structural imaging data from early psychosis and depression stages. Design, Setting, and Participants A multisite, naturalistic, longitudinal cohort study (10 sites in 5 European countries; including major follow-up intervals at 9 and 18 months) with a referred patient sample of those with clinical high risk for psychosis (CHR-P), recent-onset psychosis (ROP), recent-onset depression (ROD), and healthy controls were recruited between February 1, 2014, to July 1, 2019. Data were analyzed between January 2020 and January 2022. Main Outcomes and Measures A nonnegative matrix factorization technique separately decomposed clinical (287 variables) and parcellated brain structural volume (204 gray, white, and cerebrospinal fluid regions) data across CHR-P, ROP, ROD, and healthy controls study groups. Stability criteria determined cluster number using nested cross-validation. Validation targets were compared across subgroup solutions (premorbid, longitudinal, and schizophrenia polygenic risk scores). Multiclass supervised machine learning produced a transferable solution to the validation sample. Results There were a total of 749 individuals in the discovery group and 610 individuals in the validation group. Individuals included those with CHR-P (n = 287), ROP (n = 323), ROD (n = 285), and healthy controls (n = 464), The mean (SD) age was 25.1 (5.9) years, and 702 (51.7%) were female. A clinical 4-dimensional solution separated individuals based on positive symptoms, negative symptoms, depression, and functioning, demonstrating associations with all validation targets. Brain clustering revealed a subgroup with distributed brain volume reductions associated with negative symptoms, reduced performance IQ, and increased schizophrenia polygenic risk scores. Multilevel results distinguished between normative and illness-related brain differences. Subgroup results were largely validated in the external sample. Conclusions and Relevance The results of this longitudinal cohort study provide stratifications beyond the expression of positive symptoms that cut across illness stages and diagnoses. Clinical results suggest the importance of negative symptoms, depression, and functioning. Brain results suggest substantial overlap across illness stages and normative variation, which may highlight a vulnerability signature independent from specific presentations. Premorbid, longitudinal, and genetic risk validation suggested clinical importance of the subgroups to preventive treatments.

Published
2022

21. Accuracy of self-assessment of real-life functioning in schizophrenia

Author

Rocca, Paola, Brasso, Claudio, Montemagni, Cristiana, Bellino, Silvio, Rossi, Alessandro, Bertolino, Alessandro, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Bucci, Paola, Buzzanca, Antonino, Carpiniello, Bernardo, Cuomo, Alessandro, Dell'Osso, Liliana, Favaro, Angela, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, Maj, Mario, Bozzatello, Paola, Badino, Cristina, Giordano, Benedetta, Di Palo, Piergiuseppe, Calia, Vitalba, Papalino, Marco, Barlati, Stefano, Deste, Giacomo, Ceraso, Anna, Pinna, Federica, Olivieri, Benedetta, Manca, Daniela, Piegari, Giuseppe, Brando, Francesco, Giuliani, Luigi, Aiello, Carmen, Fusar Poli, Laura, Concerto, Carmen, Surace, Teresa, Altamura, Mario, Malerba, Stefania, Padalino, Flavia, Calcagno, Pietro, Belvederi Murri, Martino, Amerio, Andrea, Pacitti, Francesca, Socci, Valentina, Lucaselli, Alessia, Giusti, Laura, Salza, Anna, Ussorio, Donatella, Iasevoli, Felice, Gramaglia, Carla, Gambaro, Eleonora, Gattoni, Eleonora, Tenconi, Elena, Collantoni, Enrico, Meneguzzo, Paolo, Ossola, Paolo, Tonna, Matteo, Gerra, Maria Lidia, Carmassi, Claudia, Carpita, Barbara, Cremone, Ivan Mirko, Corrivetti, Giulio, Cascino, Giammarco, Marciello, Francesca, Brugnoli, Roberto, Comparelli, Anna, Corigliano, Valentina, Girardi, Nicoletta, Accinni, Tommaso, Carlone, Luca, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Rocca, P., Brasso, C., Montemagni, C., Bellino, S., Rossi, A., Bertolino, A., Gibertoni, D., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Bucci, P., Buzzanca, A., Carpiniello, B., Cuomo, A., Dell'Osso, L., Favaro, A., Giordano, G. M., Marchesi, C., Monteleone, P., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Galderisi, S., Maj, M., Bozzatello, P., Badino, C., Giordano, B., Di Palo, P., Calia, V., Papalino, M., Barlati, S., Deste, G., Ceraso, A., Pinna, F., Olivieri, B., Manca, D., Piegari, G., Brando, F., Giuliani, L., Aiello, C., Poli, L. F., Concerto, C., Surace, T., Altamura, M., Malerba, S., Padalino, F., Calcagno, P., Murri, M. B., Amerio, A., Pacitti, F., Socci, V., Lucaselli, A., Giusti, L., Salza, A., Ussorio, D., Iasevoli, F., Gramaglia, C., Gambaro, E., Gattoni, E., Tenconi, E., Collantoni, E., Meneguzzo, P., Ossola, P., Tonna, M., Gerra, M. L., Carmassi, C., Carpita, B., Cremone, I. M., Corrivetti, G., Cascino, G., Marciello, F., Brugnoli, R., Comparelli, A., Corigliano, V., Girardi, N., Accinni, T., Carlone, L., Fagiolini, A., Goracci, A., Bolognesi, S., Di Lorenzo, G., Niolu, C., Ribolsi, M., Rocca P., Brasso C., Montemagni C., Bellino S., Rossi A., Bertolino A., Gibertoni D., Aguglia E., Amore M., Andriola I., Bellomo A., Bucci P., Buzzanca A., Carpiniello B., Cuomo A., Dell'Osso L., Favaro A., Giordano G.M., Marchesi C., Monteleone P., Oldani L., Pompili M., Roncone R., Rossi R., Siracusano A., Vita A., Zeppegno P., Galderisi S., Maj M., Bozzatello P., Badino C., Giordano B., Di Palo P., Calia V., Papalino M., Barlati S., Deste G., Ceraso A., Pinna F., Olivieri B., Manca D., Piegari G., Brando F., Giuliani L., Aiello C., Poli L.F., Concerto C., Surace T., Altamura M., Malerba S., Padalino F., Calcagno P., Murri M.B., Amerio A., Pacitti F., Socci V., Lucaselli A., Giusti L., Salza A., Ussorio D., Iasevoli F., Gramaglia C., Gambaro E., Gattoni E., Tenconi E., Collantoni E., Meneguzzo P., Ossola P., Tonna M., Gerra M.L., Carmassi C., Carpita B., Cremone I.M., Corrivetti G., Cascino G., Marciello F., Brugnoli R., Comparelli A., Corigliano V., Girardi N., Accinni T., Carlone L., Fagiolini A., Goracci A., Bolognesi S., Di Lorenzo G., Niolu C., and Ribolsi M.

Subjects
Self-assessment, medicine.medical_treatment, Concordance, RC435-571, schizophrenia, real-life functioning, reliability, Article, Correlation, 03 medical and health sciences, Interpersonal relationship, 0302 clinical medicine, medicine, 030212 general & internal medicine, Self-assessment, schizophrenia, diagnosis, Psychiatry, Rehabilitation, medicine.disease, Psychosis, 030227 psychiatry, Psychiatry and Mental health, Settore MED/25, Schizophrenia, Cohort, Work Skills, Psychology, Clinical psychology
Abstract

A consensus has not yet been reached regarding the accuracy of people with schizophrenia in self-reporting their real-life functioning. In a large (n = 618) cohort of stable, community-dwelling schizophrenia patients we sought to: (1) examine the concordance of patients’ reports of their real-life functioning with the reports of their key caregiver; (2) identify which patient characteristics are associated to the differences between patients and informants. Patient-caregiver concordance of the ratings in three Specific Level of Functioning Scale (SLOF) domains (interpersonal relationships, everyday life skills, work skills) was evaluated with matched-pair t tests, the Lin’s concordance correlation, Somers’ D, and Bland–Altman plots with limits of agreement (LOA). Predictors of the patient-caregiver differences in SLOF ratings were assessed with a linear regression with multivariable fractional polynomials. Patients’ self-evaluation of functioning was higher than caregivers’ in all the evaluated domains of the SLOF and 17.6% of the patients exceeded the LOA, thus providing a self-evaluation discordant from their key caregivers. The strongest predictors of patient-caregiver discrepancies were caregivers’ ratings in each SLOF domain. In clinically stable outpatients with a moderate degree of functional impairment, self-evaluation with the SLOF scale can become a useful, informative and reliable clinical tool to design a tailored rehabilitation program.

Published
2021

22. Reduced Phase Synchronization for Auditory Deviant Detection in Schizophrenia and Clinical High Risk for Psychosis

Author

Valt, Christian, primary, Quarto, Tiziana, additional, Tavella, Angelantonio, additional, Fazio, Leonardo, additional, Andriola, Ileana, additional, Blasi, Giuseppe, additional, Calia, Vitalba, additional, D’Ambrosio, Enrico, additional, Altamura, Mario, additional, Saponaro, Alessandro, additional, Brudaglio, Flora, additional, Carofiglio, Angela, additional, Pergola, Giulio, additional, and Bertolino, Alessandro, additional

Published
2021
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23. Age-Related Prefrontal Network Connectivity Pattern Changes are Associated With Risk for Psychosis

Author

Passiatore, Roberta, primary, Antonucci, Linda, additional, DeRamus, Thomas, additional, Fazio, Leonardo, additional, Stolfa, Giuseppe, additional, Andriola, Ileana, additional, Sangiuliano, Marina, additional, Altamura, Mario, additional, Saponaro, Alessandro, additional, Brudaglio, Flora, additional, Carofiglio, Angela, additional, Popolizio, Teresa, additional, Taurisano, Paolo, additional, Sambataro, Fabio, additional, Blasi, Giuseppe, additional, Bertolino, Alessandro, additional, Calhoun, Vince, additional, and Pergola, Giulio, additional

Published
2021
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25. Lifestyle in patients with severe mental disorders: a new target for psychosocial interventions?

Author

Sampogna, Gaia, Luciano, Mario, Del Vecchio, Valeria, Giallonardo, Vincenzo, Palummo, Carmela, Andriola, Ileana, Sangiuliano, Marina, Calcagno, Pietro, Zampogna, Domenico, Rossi, Rodolfo, Stratta, Paolo, Carmassi, Claudia, Dell'Osso, Liliana, Niolu, Cinzia, Siracusano, Alberto, Fiorillo, Andrea, Sampogna, G., Luciano, M., Del Vecchio, V., Giallonardo, V., Palummo, C., Andriola, I., Sangiuliano, M., Calcagno, P., Zampogna, D., Rossi, R., Stratta, P., Carmassi, C., Dell'Osso, L., Niolu, C., Siracusano, A., and Fiorillo, A.

Subjects
Adult, obesity, Bipolar Disorder, Female, Humans, Life Style, Middle Aged, Psychosocial Intervention, Mental Disorders, Schizophrenia, comorbidity, adherence to treatment, Mental Disorder, mortality gap, lifestyle behaviour, Human
Abstract

INTRODUCTION: Patients with severe mental disorders (namely schizophrenia, major depression and bipolar disorder) have a reduced life expectancy of at least 10 to 25 years compared with the general population. This mortality gap is due to the higher prevalence of comorbid physical disorders (such as diabetes, hypertension and cardiovascular diseases) in these patients compared to the general population. Factors contributing to the mortality gap include lack of access to primary care services, severity of clinical symptoms, internalized stigma and discrimination by healthcare professionals, pharmacological treatments and unhealthy lifestyle behaviours. Several international studies have highlighted the high prevalence of unhealthy lifestyle behaviours in patients with severe mental disorders, but a few data are available from Italian real-world settings. AIM: The present study aims to: 1) describe the lifestyle behaviours adopted by a sample of real-world patients affected by severe mental disorders; 2) identify differences in lifestyle behaviours according to diagnostic category. MATERIALS: The final sample consisted of 402 patients, mainly female (57%), with a mean age of 45.8±11.8 years. 35% of them suffers from moderate obesity and 40% of them is affected by hyperinsulinemia, hypercolestereloemia and hypertrygliceridemia. 70% of patients has sedentary behaviours. Moderate to severe nicotine dependence is reported by 42% of patients. Patients with bipolar disorders are more frequently smokers compared to other patients. No significant differences in lifestyle behaviours have been found among the three diagnostic groups. RESULTS AND CONCLUSIONS: Our data confirm that patients with severe mental disorders adopt unhealthy lifestyle behaviours, regardless their diagnosis. New psychosocial interventions, including motivational and psychoeducational components and targeting lifestyle behaviours, should be developed and disseminated in order to reduce the mortality gap.

Published
2021

26. Association between age of cannabis initiation and gray matter covariance networks in recent onset psychosis

Author

Penzel, Nora, Antonucci, Linda A., Betz, Linda T., Sanfelici, Rachele, Weiske, Johanna, Pogarell, Oliver, Cumming, Paul, Quednow, Boris B., Howes, Oliver, Falkai, Peter, Upthegrove, Rachel, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Rosen, Marlene, Haidl, Theresa, Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Salokangas, Raimo R.K., Pantelis, Christos, Wood, Stephen J., Koutsouleris, Nikolaos, Kambeitz, Joseph, Sen Dong, Mark, Erkens, Anne, Gussmann, Eva, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Kohler, Janis, Ozturk, Omer Faruk, Popovic, David, Rangnick, Adrian, von Saldern, Sebastian, Spangemacher, Moritz, Tupac, Ana, Urquijo, Maria Fernanda, Wosgien, Antonia, Blume, Karsten, Seves, Mauro, Kaiser, Nathalie, Pilgram, Tanja, Lichtenstein, Thorsten, Wenzel, Julian, Woopen, Christiane, Andreou, Christina, Egloff, Laura, Harrisberger, Fabienne, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Chisholm, Katharine, Day, Chris, Griffiths, Sian Lowri, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Denissoff, Alexander, Ellila, Anu, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Paivi, Laurikainen, Heikki, Lehtinen, Maarit, Luutonen, Antti, Makela, Akseli, Paju, Janina, Pesonen, Henri, Armio (Saila), Reetta Liina, Sormunen, Elina, Toivonen, Anna, Turtonen, Otto, Solana, Ana Beatriz, Abraham, Manuela, Hehn, Nicolas, Schirmer, Timo, Altamura, Carlo, Belleri, Marika, Bottinelli, Francesca, Ferro, Adele, Re, Marta, Monzani, Emiliano, Percudani, Mauro, Sberna, Maurizio, D’Agostino, Armando, Del Fabro, Lorenzo, Perna, Giampaolo, Nobile, Maria, Alciati, Alessandra, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Garzitto, Marco, Piccin, Sara, Blasi, Giuseppe, Pergola, Giulio, Caforio, Grazia, Faio, Leonardo, Quarto, Tiziana, Gelao, Barbara, Romano, Raffaella, Andriola, Ileana, Falsetti, Andrea, Barone, Marina, Passatiore, Roberta, Sangiuliano, Marina, Surman, Marian, Bienek, Olga, Romer, Georg, Dannlowski, Udo, Schultze-Lutter, Frauke, Schmidt-Kraepelin, Christian, Neufang, Susanne, Korda, Alexandra, Rohner, Henrik, other, and, Penzel, Nora, Antonucci, Linda A., Betz, Linda T., Sanfelici, Rachele, Weiske, Johanna, Pogarell, Oliver, Cumming, Paul, Quednow, Boris B., Howes, Oliver, Falkai, Peter, Upthegrove, Rachel, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Lencer, Rebekka, Meisenzahl, Eva, Rosen, Marlene, Haidl, Theresa, Kambeitz-Ilankovic, Lana, Ruhrmann, Stephan, Salokangas, Raimo R.K., Pantelis, Christos, Wood, Stephen J., Koutsouleris, Nikolaos, Kambeitz, Joseph, Sen Dong, Mark, Erkens, Anne, Gussmann, Eva, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Kohler, Janis, Ozturk, Omer Faruk, Popovic, David, Rangnick, Adrian, von Saldern, Sebastian, Spangemacher, Moritz, Tupac, Ana, Urquijo, Maria Fernanda, Wosgien, Antonia, Blume, Karsten, Seves, Mauro, Kaiser, Nathalie, Pilgram, Tanja, Lichtenstein, Thorsten, Wenzel, Julian, Woopen, Christiane, Andreou, Christina, Egloff, Laura, Harrisberger, Fabienne, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Chisholm, Katharine, Day, Chris, Griffiths, Sian Lowri, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Denissoff, Alexander, Ellila, Anu, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Paivi, Laurikainen, Heikki, Lehtinen, Maarit, Luutonen, Antti, Makela, Akseli, Paju, Janina, Pesonen, Henri, Armio (Saila), Reetta Liina, Sormunen, Elina, Toivonen, Anna, Turtonen, Otto, Solana, Ana Beatriz, Abraham, Manuela, Hehn, Nicolas, Schirmer, Timo, Altamura, Carlo, Belleri, Marika, Bottinelli, Francesca, Ferro, Adele, Re, Marta, Monzani, Emiliano, Percudani, Mauro, Sberna, Maurizio, D’Agostino, Armando, Del Fabro, Lorenzo, Perna, Giampaolo, Nobile, Maria, Alciati, Alessandra, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Garzitto, Marco, Piccin, Sara, Blasi, Giuseppe, Pergola, Giulio, Caforio, Grazia, Faio, Leonardo, Quarto, Tiziana, Gelao, Barbara, Romano, Raffaella, Andriola, Ileana, Falsetti, Andrea, Barone, Marina, Passatiore, Roberta, Sangiuliano, Marina, Surman, Marian, Bienek, Olga, Romer, Georg, Dannlowski, Udo, Schultze-Lutter, Frauke, Schmidt-Kraepelin, Christian, Neufang, Susanne, Korda, Alexandra, Rohner, Henrik, and other, and

Abstract

Cannabis use during adolescence is associated with an increased risk of developing psychosis. According to a current hypothesis, this results from detrimental effects of early cannabis use on brain maturation during this vulnerable period. However, studies investigating the interaction between early cannabis use and brain structural alterations hitherto reported inconclusive findings. We investigated effects of age of cannabis initiation on psychosis using data from the multicentric Personalized Prognostic Tools for Early Psychosis Management (PRONIA) and the Cannabis Induced Psychosis (CIP) studies, yielding a total sample of 102 clinically-relevant cannabis users with recent onset psychosis. GM covariance underlies shared maturational processes. Therefore, we performed source-based morphometry analysis with spatial constraints on structural brain networks showing significant alterations in schizophrenia in a previous multisite study, thus testing associations of these networks with the age of cannabis initiation and with confounding factors. Earlier cannabis initiation was associated with more severe positive symptoms in our cohort. Greater gray matter volume (GMV) in the previously identified cerebellar schizophrenia-related network had a significant association with early cannabis use, independent of several possibly confounding factors. Moreover, GMV in the cerebellar network was associated with lower volume in another network previously associated with schizophrenia, comprising the insula, superior temporal, and inferior frontal gyrus. These findings are in line with previous investigations in healthy cannabis users, and suggest that early initiation of cannabis perturbs the developmental trajectory of certain structural brain networks in a manner imparting risk for psychosis later in life.

Published
2021

27. The Complex Interplay Between Physical Activity and Recovery Styles in Patients With Severe Mental Disorders in a Real-World Multicentric Study.

Author

Sampogna, Gaia, Luciano, Mario, Di Vincenzo, Matteo, Andriola, Ileana, D'Ambrosio, Enrico, Amore, Mario, Serafini, Gianluca, Rossi, Alessandro, Carmassi, Claudia, Dell'Osso, Liliana, Di Lorenzo, Giorgio, Siracusano, Alberto, Rossi, Rodolfo, and Fiorillo, Andrea

Subjects
MENTAL illness, PHYSICAL activity, PEOPLE with mental illness, HEALTH behavior, SEDENTARY behavior
Abstract

Compared with the general population, people with severe mental disorders have significantly worse physical health and a higher mortality rate, which is partially due to the adoption of unhealthy lifestyle behaviors, such as heavy smoking, use of alcohol or illicit drugs, unbalanced diet, and physical inactivity. These unhealthy behaviors may also play a significant role in the personal and functional recovery of patients with severe mental disorders, although this relationship has been rarely investigated in methodologically robust studies. In this paper, we aim to: a) describe the levels of physical activity and recovery style in a sample of patients with severe mental disorders; b) identify the clinical, social, and illness-related factors that predict the likelihood of patients performing physical activity. The global sample consists of 401 patients, with a main psychiatric diagnosis of bipolar disorder (43.4%, N = 174), psychosis spectrum disorder (29.7%; N = 119), or major depression (26.9%; N = 118). 29.4% (N = 119) of patients reported performing physical activity regularly, most frequently walking (52.1%, N = 62), going to the gym (21.8%, N = 26), and running (10.9%, N = 13). Only 15 patients (3.7%) performed at least 75min of vigorous physical activity per week. 46.8% of patients adopted sealing over as a recovery style and 37.9% used a mixed style toward integration. Recovery style is influenced by gender (p < 0.05) and age (p < 0.05). The probability to practice regular physical activity is higher in patients with metabolic syndrome (Odds Ratio - OR: 2.1; Confidence Interval - CI 95%: 1.2-3.5; p < 0.050), and significantly lower in those with higher levels of anxiety/depressive symptoms (OR: 0.877; CI 95%: 0.771-0.998; p < 0.01). Globally, patients with severe mental disorders report low levels of physical activities, which are associated with poor recovery styles. Psychoeducational interventions aimed at increasing patients' motivation to adopt healthy lifestyle behaviors and modifying recovery styles may improve the physical health of people with severe mental disorders thus reducing the mortality rates. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Evidence of an interaction between FXR1 and GSK3β polymorphisms on levels of Negative Symptoms of Schizophrenia and their response to antipsychotics

Author

Rampino, Antonio, primary, Torretta, Silvia, additional, Gelao, Barbara, additional, Veneziani, Federica, additional, Iacoviello, Matteo, additional, Marakhovskaya, Aleksandra, additional, Masellis, Rita, additional, Andriola, Ileana, additional, Sportelli, Leonardo, additional, Pergola, Giulio, additional, Minelli, Alessandra, additional, Magri, Chiara, additional, Gennarelli, Massimo, additional, Vita, Antonio, additional, Beaulieu, Jean Martin, additional, Bertolino, Alessandro, additional, and Blasi, Giuseppe, additional

Published
2021
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29. Converging Evidence for the Association of Functional Genetic Variation in the Serotonin Receptor 2a Gene With Prefrontal Function and Olanzapine Treatment

Author

Blasi, Giuseppe, De Virgilio, Caterina, Papazacharias, Apostolos, Taurisano, Paolo, Gelao, Barbara, Fazio, Leonardo, Ursini, Gianluca, Sinibaldi, Lorenzo, Andriola, Ileana, Masellis, Rita, Romano, Raffaella, Rampino, Antonio, Di Giorgio, Annabella, Lo Bianco, Luciana, Caforio, Grazia, Piva, Francesco, Popolizio, Teresa, Bellantuono, Cesario, Todarello, Orlando, Kleinman, Joel E., Gadaleta, Gemma, Weinberger, Daniel R., and Bertolino, Alessandro

Published
2013
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30. Personal resources and depression in schizophrenia: The role of self-esteem, resilience and internalized stigma

Author

Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Rucci, Paola, Gibertoni, Dino, Stratta, Paolo, Bucci, Paola, Mucci, Armida, Aguglia, Eugenio, Amodeo, Giovanni, Amore, Mario, Bellomo, Antonello, Brugnoli, Roberto, Caforio, Grazia, Carpiniello, Bernardo, Dell'Osso, Liliana, di Fabio, Fabio, di Giannantonio, Massimo, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Zeppegno, Patrizia, Maj, Mario, Andriola, Ileana, Paladini, Vittoria, Mancini, Marina, Ferrari, Barbara, Vita, Antonio, Barlati, Stefano, Galluzzo, Alessandro, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Martinotti, Giovanni, Lupi, Matteo, Corbo, Mariangela, Ricca, Valdo, Burchi, Elisabetta, Altamura, Mario, Carnevale, Raffaella, Petito, Annamaria, Belvederi Murri, Martino, Calcagno, Pietro, Corso, Alessandro, Rossetti, Maria Cristina, Rossi, Rodolfo, Santarelli, Valeria, Giusti, Laura, Malavolta, Maurizio, Ussorio, Donatella, Serati, Marta, De Simone, Stefania, Vignapiano, Annarita, Montefusco, Valentina, Plescia, Giuseppe Maria, Palumbo, Davide, Iasevoli, Felice, Gramaglia, Carla, Feggi, Alessandro, Gattoni, Eleonora, Campagnola, Nadia, Collantoni, Enrico, Tenconi, Elena, De Panfilis, Chiara, Tonna, Matteo, Ossola, Paolo, Gesi, Camilla, Rutigliano, Grazia, Landi, Paola, Biondi, Massimo, Girardi, Paolo, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Bava, Irene, Mancini, Irene, Cardillo, Simona, Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Rucci, Paola, Gibertoni, Dino, Stratta, Paolo, Bucci, Paola, Mucci, Armida, Aguglia, Eugenio, Amodeo, Giovanni, Amore, Mario, Bellomo, Antonello, Brugnoli, Roberto, Caforio, Grazia, Carpiniello, Bernardo, Dell'Osso, Liliana, di Fabio, Fabio, di Giannantonio, Massimo, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Zeppegno, Patrizia, Maj, Mario, Andriola, Ileana, Paladini, Vittoria, Mancini, Marina, Ferrari, Barbara, Vita, Antonio, Barlati, Stefano, Galluzzo, Alessandro, Pinna, Federica, Primavera, Diego, Sanna, Lucia, Signorelli, Maria Salvina, Cannavã², Dario, Minutolo, Giuseppe, Martinotti, Giovanni, Lupi, Matteo, Corbo, Mariangela, Ricca, Valdo, Burchi, Elisabetta, Altamura, Mario, Carnevale, Raffaella, Petito, Annamaria, Murri, Martino Belvederi, Calcagno, Pietro, Corso, Alessandro, Rossetti, Maria Cristina, Rossi, Rodolfo, Santarelli, Valeria, Giusti, Laura, Malavolta, Maurizio, Ussorio, Donatella, Serati, Marta, De Simone, Stefania, Vignapiano, Annarita, Montefusco, Valentina, Plescia, Giuseppe Maria, Palumbo, Davide, Iasevoli, Felice, Gramaglia, Carla, Feggi, Alessandro, Gattoni, Eleonora, Campagnola, Nadia, Collantoni, Enrico, Tenconi, Elena, De Panfilis, Chiara, Tonna, Matteo, Ossola, Paolo, Gesi, Camilla, Rutigliano, Grazia, Landi, Paola, Biondi, Massimo, Girardi, Paolo, Buzzanca, Antonino, Comparelli, Anna, De Carolis, Antonella, Di Lorenzo, Giorgio, Niolu, Cinzia, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Diasco, Ferdinando, Fagiolini, Andrea, Goracci, Arianna, Bolognesi, Simone, Bava, Irene, Mancini, Irene, Cardillo, Simona, DELLA ROCCA, Paola, Cannavò, Dario, Antonio, Vita, and Martino Belvederi, Murri

Subjects
Adult, Male, Social stigma, Adolescent, media_common.quotation_subject, Schizophrenia (object-oriented programming), Social Stigma, Affect (psychology), NO, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Humans, Settore MED/25 - Psichiatria, Avolition, Biological Psychiatry, media_common, Aged, Resilience, Depression, Resilience, Psychological, Middle Aged, Self Concept, 030227 psychiatry, Cross-Sectional Studies, Female, Schizophrenia, Schizophrenic Psychology, Psychiatry and Mental Health, Psychological, Psychological resilience, medicine.symptom, Biological psychiatry, Psychology, Psychosocial, 030217 neurology & neurosurgery, Psychopathology, Clinical psychology
Abstract

Depression in schizophrenia represents a challenge from a diagnostic, psychopathological and therapeutic perspective. The objective of this study is to test the hypothesis that resilience and self-stigma affect depression severity and to evaluate the strength of their relations in 921 patients with schizophrenia. A structural equation model was tested where depression is hypothesized as affected by resilience, internalized stigma, gender and negative symptoms, with the latter two variables used as exogenous covariates and the former two as mediators. The analysis reveals that low resilience, high negative symptoms, female gender were directly associated with depression severity, and internalized stigma acted only as a mediator between avolition and resilience, with similar magnitude. The cross-sectional study design and the variable selection limit the generalizability of the study results. The model supports a complex interaction between personal resources and negative symptoms in predicting depression in schizophrenia. The clinical implication of these findings is that personal resources could be a significant target of psychosocial treatments.

Published
2017

31. Disorganization and real-world functioning in schizophrenia: Results from the multicenter study of the Italian Network for Research on Psychoses

Author

Rocca, P., primary, Galderisi, S., additional, Rossi, A., additional, Bertolino, A., additional, Rucci, P., additional, Gibertoni, D., additional, Montemagni, C., additional, Bellino, S., additional, Aguglia, E., additional, Amore, M., additional, Bellomo, A., additional, Biondi, M., additional, Carpiniello, B., additional, Cuomo, A., additional, D'Ambrosio, E., additional, dell'Osso, L., additional, Girardi, P., additional, Marchesi, C., additional, Monteleone, P., additional, Montemitro, C., additional, Oldani, L., additional, Pacitti, F., additional, Roncone, R., additional, Siracusano, A., additional, Tenconi, E., additional, Vita, A., additional, Zeppegno, P., additional, Steardo, L., additional, Vignapiano, A., additional, Maj, M., additional, Bracale, Nadja, additional, Cardillo, Simona, additional, Brasso, Claudio, additional, Andriola, Ileana, additional, Romano, Raffaella, additional, Caforio, Grazia, additional, Barlati, Stefano, additional, Galluzzo, Alessandro, additional, Deste, Giacomo, additional, Pinna, Federica, additional, Lostia di S. Sofia, Silvia, additional, Lai, Alice, additional, Signorelli, Maria Salvina, additional, Corbo, Mariangela, additional, Baroni, Gaia, additional, Lupi, Matteo, additional, Altamura, Mario, additional, La Montagna, Maddalena, additional, Malerba, Stefania, additional, Murri, Martino Belvederi, additional, Corso, Alessandro, additional, Bugliani, Michele, additional, Pizziconi, Giulia, additional, Rossi, Rodolfo, additional, Serrone, Dario, additional, Giusti, Laura, additional, Ussorio, Donatella, additional, Salza, Anna, additional, Merlotti, Eleonora, additional, Piegari, Giuseppe, additional, Patriarca, Sara, additional, Pietrafesa, Daria, additional, de Bartolomeis, Andrea, additional, Gramaglia, Carla, additional, Gattoni, Eleonora, additional, Marangon, Debora, additional, Grottaroli, Marika, additional, Pigoni, Alessandro, additional, Grassi, Silvia, additional, Cremonese, Carla, additional, Meneguzzo, Paolo, additional, Collantoni, Enrico, additional, Tonna, Matteo, additional, Ossola, Paolo, additional, Gerra, Maria Lidia, additional, Gesi, Camilla, additional, Cremone, IvanMirko, additional, Carpita, Barbara, additional, Brugnoli, Roberto, additional, Comparelli, Anna, additional, Corigliano, Valentina, additional, Di Fabio, Fabio, additional, Buzzanca, Antonio, additional, Girardi, Nicoletta, additional, Niolu, Cinzia, additional, Di Lorenzo, Giorgio, additional, Ribolsi, Michele, additional, Corrivetti, Giulio, additional, Bartoli, Luca, additional, Diasco, Ferdinando, additional, Fagiolini, Andrea, additional, Bolognesi, Simone, additional, and Goracci, Arianna, additional

Published
2018
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32. How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention.

Author

Luciano, Mario, Sampogna, Gaia, Amore, Mario, Andriola, Ileana, Calcagno, Pietro, Carmassi, Claudia, Del Vecchio, Valeria, Dell'Osso, Liliana, Di Lorenzo, Giorgio, Gelao, Barbara, Giallonardo, Vincenzo, Rossi, Alessandro, Rossi, Rodolfo, Siracusano, Alberto, and Fiorillo, Andrea

Subjects
PEOPLE with mental illness, RANDOMIZED controlled trials, SCHIZOPHRENIA, PSYCHOSOCIAL functioning, MENTAL depression
Abstract

Background. People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, with a decade of years of life lost. In this randomized controlled trial (RCT), we assessed in a sample of people with bipolar disorder, major depressive disorder, and schizophrenia spectrum disorder, the efficacy of an innovative psychosocial group intervention compared to a brief psychoeducational group intervention on patients' body mass index (BMI), body weight, waist circumference, Framingham and HOMA-IR indexes. Methods. This is a multicentric RCT with blinded outcome assessments carried out in six Italian university centers. After recruitment patients were randomized to receive a 6-month psychosocial intervention to improve patients' physical health or a brief psychoeducational intervention. All recruited patients were assessed with standardized assessment instruments at baseline and after 6 months. Anthropometric parameters and blood samples have also been collected. Results. Four-hundred and two patients with a diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were randomly allocated to the experimental (N = 206) or the control group (N = 195). After 6 months, patients from the experimental group reported a significant reduction in BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31-2.84; p < 0.001), body weight (OR = 4.78, 95% CI: 0.80-28.27, p < 0.05), and waist circumference (OR = 5.43, 95% CI: 1.45-20.30, p < 0.05). Participants with impaired cognitive and psychosocial functioning had a worse response to the intervention. Conclusions. The experimental group intervention was effective in improving the physical health in SMI patients. Further studies are needed to evaluate the feasibility of this intervention in real-world settings. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements

Author

Piluso, Giulio, Monteleone, Palmiero, Galderisi, Silvana, Giugliano, Teresa, Bertolino, Alessandro, Rocca, Paola, Rossi, Alessandro, Mucci, Armida, Aguglia, Eugenio, Andriola, Ileana, Bellomo, Antonello, Comparelli, Anna, Gambi, Francesco, Fagiolini, Andrea, Marchesi, Carlo, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, Stratta, Paolo, Tortorella, Alfonso, Steardo, Luca Jr, Bucci, Paola, Nigro, Vincenzo, Maj, Mario, Italian Network for Research on Psychoses, Montefusco, Valentina, Plescia, Giuseppe, Piegari, Giuseppe, Merlotti, Eleonora, Cimmino, Monica, Savarese, Marco, D’Ambrosio, Enrico, Atti, Anna Rita, Valsecchi, Paolo, Signorelli, Maria Salvina, Acciavatti, Tiziano, Altamura, Mario, Arzani, Costanza, Callista, Gaetano, Pacitti, Francesca, Oldani, Lucio, Gramaglia, Carla, Tenconi, Elena, Camerlengo, Annalisa, Dell’Osso, Liliana, Brugnoli, Roberto, Di Fabio, Fabio, Niolu, Cinzia, Corrivetti, Giulio, Bolognesi, Simone, Montemagni, Cristina, Piluso, G., Monteleone, P., Galderisi, S., Giugliano, T., Bertolino, A., Rocca, P., Rossi, A., Mucci, A., Aguglia, E., Andriola, I., Bellomo, A., Comparelli, A., Gambi, F., Fagiolini, A., Marchesi, C., Roncone, R., Sacchetti, E., Santonastaso, P., Siracusano, A., Stratta, P., Tortorella, A., Steardo, L., Bucci, P., Nigro, V., Maj, M., Montefusco, V., Plescia, G., Piegari, G., Merlotti, E., Cimmino, M., Savarese, M., D'Ambrosio, E., Atti, A. R., Valsecchi, P., Signorelli, M. S., Acciavatti, T., Altamura, M., Arzani, Costanza., Callista, G., Pacitti, F., Oldani, L., Gramaglia, C., Tenconi, E., Camerlengo, A., Dell'Osso, L., Brugnoli, R., Di Fabio, F., Niolu, C., Corrivetti, G., Bolognesi, S., and Montemagni, C.

Subjects
family trios, Adult, Male, DNA Copy Number Variations, Schizophrenia (object-oriented programming), Schizophrenia, de novo CNV, enhancers, genetics, Schizophrenia, genetics, enhancers, de novo CNV, family trios, family trio, Biology, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, mental disorders, Humans, Genetic Predisposition to Disease, Copy-number variation, Enhancer, Gene, Biological Psychiatry, Enhancer Elements, Genetics, Middle Aged, 030227 psychiatry, Enhancer Elements, Genetic, Settore MED/25, Italy, Psychiatry and Mental Health, Mutation, Female, enhancer, genetic, Biological psychiatry
Abstract

Objectives: Variants appearing de novo in genes regulating key neurodevelopmental processes and/or in non-coding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement in schizophrenia needs to be explored more deeply. Methods: We investigated de novo copy-number variations (CNVs) in the whole-genomic DNA obtained from 46 family trios of schizophrenia probands by using the Enhancer Chip, a customised array CGH able to investigate the whole genome with a 300-kb resolution, specific disease loci at a ten-fold higher resolution, and which was highly enriched in probes in more than 1,250 enhancer elements selected from Vista Enhancer Browser. Results: In seven patients, we found de novo CNVs, two of which overlapped VISTA enhancer elements. De novo CNVs encompass genes (CNTNAP2, MAGI1, TSPAN7 and MET) involved in brain development, while that involving the enhancer element hs1043, also includes ZIC1, which plays a role in neural development and is responsible of behavioural abnormalities in Zic mutant mice. Conclusions: These findings provide further evidence for the involvement of de novo CNVs in the pathogenesis of schizophrenia and suggest that CNVs affecting regulatory enhancer elements could contribute to the genetic vulnerability to the disorder.

Published
2017

34. The Brief Negative Symptom Scale (BNSS): Independent validation in a large sample of Italian patients with schizophrenia

Author

MUCCI, Armida, GALDERISI, Silvana, MERLOTTI, Eleonora, BUCCI, Paola, PIEGARI, Giuseppe, MAJ, Mario, Rossi, A., Rocca, P., Chieffi, M., Vignapiano, A., Campana, Teresa, De Simone, Stefania, Gallo, Olimpia, Giugliano, Rosa, LUCIANO, Mario, Montefusco, Valentina, Plescia, Giuseppe, Sampogna, Gaia, Andriola, Ileana, Porcelli, Stefano, Galluzzo, Alessandro, Signorini, Giulia, Bulgari, Viola, Pinna, Federica, Signorelli, Maria Salvina, di Giannantonio, Massimo, Bellomo, Antonello, Calcagno, Pietro, Roncone, Rita, Stratta, Paolo, Buoli, Massimiliano, Zeppegno, Patrizia, Giannunzio, Valeria, Marchesi, Carlo, Dell'Osso, Liliana, Squarcione, Chiara, Comparelli, Anna, Niolu, Cinzia, Monteleone, Palmiero, Goracci, Arianna, Montemagni, Cristiana, Mucci, Armida, Galderisi, Silvana, Merlotti, Eleonora, Rossi, A., Rocca, P., Bucci, Paola, Piegari, Giuseppe, Chieffi, M., Vignapiano, A., Maj, Mario, Campana, Teresa, De Simone, Stefania, Gallo, Olimpia, Giugliano, Rosa, Luciano, Mario, Montefusco, Valentina, Plescia, Giuseppe, Sampogna, Gaia, Andriola, Ileana, Porcelli, Stefano, Galluzzo, Alessandro, Signorini, Giulia, Bulgari, Viola, Pinna, Federica, Signorelli, Maria Salvina, di Giannantonio, Massimo, Bellomo, Antonello, Calcagno, Pietro, Roncone, Rita, Stratta, Paolo, Buoli, Massimiliano, Zeppegno, Patrizia, Giannunzio, Valeria, Marchesi, Carlo, Dell'Osso, Liliana, Squarcione, Chiara, Comparelli, Anna, Niolu, Cinzia, Monteleone, Palmiero, Goracci, Arianna, and Montemagni, Cristiana

Subjects
Adult, Male, medicine.medical_specialty, Psychometrics, Intraclass correlation, Asociality, Negative symptom, Avolition, Negative symptoms, Poor emotion expression, Primary negative symptoms, Schizophrenia, Psychiatry and Mental Health, Medicine (all), 03 medical and health sciences, 0302 clinical medicine, Brief Psychiatric Rating Scale, medicine, Humans, Affective Symptoms, Psychiatry, Settore MED/25 - Psichiatria, Discriminant validity, Anhedonia, Reproducibility of Results, Middle Aged, Female, Italy, Schizophrenic Psychology, 030227 psychiatry, Convergent validity, medicine.symptom, Primary negative symptom, Psychology, 030217 neurology & neurosurgery, Clinical psychology
Abstract

BackgroundThe Brief Negative Symptom Scale (BNSS) was developed to address the main limitations of the existing scales for the assessment of negative symptoms of schizophrenia. The initial validation of the scale by the group involved in its development demonstrated good convergent and discriminant validity, and a factor structure confirming the two domains of negative symptoms (reduced emotional/verbal expression and anhedonia/asociality/avolition). However, only relatively small samples of patients with schizophrenia were investigated. Further independent validation in large clinical samples might be instrumental to the broad diffusion of the scale in clinical research.MethodsThe present study aimed to examine the BNSS inter-rater reliability, convergent/discriminant validity and factor structure in a large Italian sample of outpatients with schizophrenia.ResultsOur results confirmed the excellent inter-rater reliability of the BNSS (the intraclass correlation coefficient ranged from 0.81 to 0.98 for individual items and was 0.98 for the total score). The convergent validity measures had r values from 0.62 to 0.77, while the divergent validity measures had r values from 0.20 to 0.28 in the main sample (n = 912) and in a subsample without clinically significant levels of depression and extrapyramidal symptoms (n = 496). The BNSS factor structure was supported in both groups.ConclusionsThe study confirms that the BNSS is a promising measure for quantifying negative symptoms of schizophrenia in large multicenter clinical studies.

Published
2015

35. Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements.

Author

Piluso, Giulio, Monteleone, Palmiero, Galderisi, Silvana, Giugliano, Teresa, Bertolino, Alessandro, Rocca, Paola, Rossi, Alessandro, Mucci, Armida, Aguglia, Eugenio, Andriola, Ileana, Bellomo, Antonello, Comparelli, Anna, Gambi, Francesco, Fagiolini, Andrea, Marchesi, Carlo, Roncone, Rita, Sacchetti, Emilio, Santonastaso, Paolo, Siracusano, Alberto, and Stratta, Paolo

Subjects
PEOPLE with schizophrenia, NEURAL development, GENETIC disorders, SCHIZOPHRENIA
Abstract

Objectives: Variants appearing de novo in genes regulating key neurodevelopmental processes and/or in non-coding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement in schizophrenia needs to be explored more deeply. Methods: We investigated de novo copy-number variations (CNVs) in the whole-genomic DNA obtained from 46 family trios of schizophrenia probands by using the Enhancer Chip, a customised array CGH able to investigate the whole genome with a 300-kb resolution, specific disease loci at a ten-fold higher resolution, and which was highly enriched in probes in more than 1,250 enhancer elements selected from Vista Enhancer Browser. Results: In seven patients, we found de novo CNVs, two of which overlapped VISTA enhancer elements. De novo CNVs encompass genes (CNTNAP2, MAGI1, TSPAN7 and MET) involved in brain development, while that involving the enhancer element hs1043, also includes ZIC1, which plays a role in neural development and is responsible of behavioural abnormalities in Zic mutant mice. Conclusions: These findings provide further evidence for the involvement of de novo CNVs in the pathogenesis of schizophrenia and suggest that CNVs affecting regulatory enhancer elements could contribute to the genetic vulnerability to the disorder. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Poster #S68 GREY MATTER VOLUME ALTERATIONS IN PATIENTS WITH SCHIZOPHRENIA AND UNAFFECTED SIBLINGS SHOW REGION-SPECIFIC EFFECTS OF GENETIC RISK AND DISEASE-RELATED FACTORS

Author

Trizio, Silvestro, primary, Pergola, Giulio, additional, Di Giorgio, Annabella, additional, D'Ambrosio, Enrico, additional, Andriola, Ileana, additional, Gelao, Barbara, additional, Marvulli, Daniela, additional, Taurisano, Paolo, additional, Fazio, Leonardo, additional, Blasi, Giuseppe, additional, and Bertolino, Alessandro, additional

Published
2014
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37. PRELIMINARY ASSOCIATION OF ESR1 GENETIC VARIATION WITH SCHIZOPHRENIA AND WORKING MEMORY PERFORMANCE

Author

Todarello, Giovanna, primary, Andriola, Ileana, additional, Di Giorgio, Annabella, additional, Rizzo, Miriam, additional, Masellis, Rita, additional, Ursini, Gianluca, additional, Castellana, Chiara, additional, Romano, Raffaella, additional, Gelao, Barbara, additional, Attrotto, Maria Teresa, additional, Blasi, Giuseppe, additional, Caforio, Grazia, additional, Nardini, Marcello, additional, and Bertolino, Alessandro, additional

Published
2010
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38. Exploring vortioxetine combination with intranasal esketamine: A feasible alternative to SSRI/SNRI? - Insights from the REAL-ESK study.

Author

d'Andrea, Giacomo, Miuli, Andrea, Pettorruso, Mauro, Cavallotto, Clara, Marrangone, Carlotta, Cocco, Alessio, De Filippis, Sergio, Martiadis, Vassillis, Andriola, Ileana, Barlati, Stefano, Vita, Antonio, Dell'Osso, Bernardo Maria, Sensi, Stefano L., Di Lorenzo, Giorgio, and Martinotti, Giovanni

Subjects
*MENTAL depression, *PSYCHIATRIC rating scales, *SEROTONIN uptake inhibitors, *INTRANASAL medication, *RANDOMIZED controlled trials
Abstract

Treatment-Resistant Depression (TRD) affects almost 30 % of patients with Major Depressive Disorder (MDD). Esketamine Nasal Spray (ESK-NS) has recently been approved for TRD in combination with a Serotonin Specific Reuptake Inhibitor/SSRI or a Serotonin-Norepinephrine Reuptake Inhibitor/SNRI. There is a lack of studies investigating the effectiveness and safety of ESK-NS in combination with other oral antidepressants. To assess the efficacy of Vortioxetine plus ESK-NS in mitigating depressive symptoms and emotional blunting, as well as its tolerability in TRD subjects, compared to the standard-of-care of SSRI/SNRI plus ESK-NS. We conducted a post-hoc analysis of the REAL-ESK study. The study included twenty TRD patients, ten subjects taking Vortioxetine as the main oral antidepressant with ESK-NS, and ten subjects taking SSRI or SNRI with ESK-NS. Psychometric assessments (Montgomery-Åsberg Depression Rating Scale/MADRS, Brief Psychiatric Rating Scale/BPRS) were conducted at baseline(T0), one month(T1), and three months after the treatment initiation(T2). The combination of Vortioxetine and ESK-NS was as effective as the standard-of-care in reducing depressive symptoms, with a higher effect size in reducing emotional blunting at T2. The safety and tolerability profile of the Vortioxetine+ESK-NS combination appeared to be better, with a lower rate of treatment-emergent adverse events. The combination of Vortioxetine and ESK-NS may be a valuable alternative to the standard-of-care SSRI/SNRI plus ESK-NS in TRD patients, particularly regarding the reduction of emotional blunting and potentially a better safety and tolerability profile. Further randomized controlled trials with larger sample sizes and prospective designs are needed to confirm these findings. • Esketamine nasal spray (ESK-NS) is a new treatment for TRD. • Standard-of-care combines ESK-NS with SSRIs or SNRIs. • We compared the effectiveness of Vortioxetine + ESK-NS vs. SSRI/SNRI + ESK-NS. • We found similar antidepressant effect with a better safety profile for Vortioxetine. • Vortioxetine + ESK-NS was more effective against emotional blunting. [ABSTRACT FROM AUTHOR]

Published
2024
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39. COMT VAL158MET, HIPPOCAMPAL FUNCTION AND GENETIC RISK FOR SCHIZOPHRENIA

Author

Di Giorgio, Annabella, Gelao, Barbara, Elifani, Francesca, Caforio, Grazia, Romano, Raffaella, Andriola, Ileana, Papazacharias, Apostolos, Ursini, Gianluca, Fazio, Leonardo, Paolo Taurisano, Lobianco, Luciana, Sinibaldi, Lorenzo, Popolizio, Teresa, Blasi, Giuseppe, and Bertolino, Alessandro

40. Association between Working Memory Processing and BDNF Val66 Epigenetic Methylation

Author

Ursini, Gianluca, Cavalleri, Tommaso, Fazio, Leonardo, Lorenzo Sinibaldi, Tarantini, Letizia, Mancini, Marina, Porcelli, Annamaria, Gelao, Barbara, Andriola, Ileana, Miccolis, Grazia, Taurisano, Paolo, Rampino, Antonio, Di Giorgio, Annabella, Popolizio, Teresa, Caforio, Grazia, Blasi, Giuseppe, Bollati, Valentina, and Bertolino, Alessandro

41. Evolution of antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia in the real-life: A 4-year follow-up naturalistic study

Author

Palmiero Monteleone, Giammarco Cascino, Alessandro Rossi, Paola Rocca, Alessandro Bertolino, Eugenio Aguglia, Mario Amore, Ileana Andriola, Antonello Bellomo, Massimo Biondi, Claudio Brasso, Bernardo Carpiniello, Enrico Collantoni, Liliana Dell'Osso, Massimo di Giannantonio, Michele Fabrazzo, Andrea Fagiolini, Giulia Maria Giordano, Matteo Marcatili, Carlo Marchesi, Alessio Maria Monteleone, Maurizio Pompili, Rita Roncone, Alberto Siracusano, Antonio Vita, Patrizia Zeppegno, Silvana Galderisi, Mario Maj, Monteleone, Palmiero, Cascino, Giammarco, Rossi, Alessandro, Rocca, Paola, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Biondi, Massimo, Brasso, Claudio, Carpiniello, Bernardo, Collantoni, Enrico, Dell'Osso, Liliana, di Giannantonio, Massimo, Fabrazzo, Michele, Fagiolini, Andrea, Giordano, Giulia Maria, Marcatili, Matteo, Marchesi, Carlo, Monteleone, Alessio Maria, Pompili, Maurizio, Roncone, Rita, Siracusano, Alberto, Vita, Antonio, Zeppegno, Patrizia, Galderisi, Silvana, and Maj, Mario

Subjects
Antipsychotics, Evolution, Extrapyramidal side effects, Naturalistic study, Schizophrenia, Antipsychotic, Extrapyramidal side effect, Psychiatry and Mental health, Humans, Biological Psychiatry, Antipsychotic Agents, Follow-Up Studies
Abstract

Previous studies have shown, although not consistently, that first generation antipsychotics (FGA) are associated with a prevalence of extrapyramidal symptoms (EPS) higher than second generation antipsychotics (SGA). We assessed the prevalence and the incidence of antipsychotic-induced EPS in a large sample of community-dwelling Italian persons with schizophrenia before and after a 4-year naturalistic treatment, to shed light on their natural evolution and to identify possible predicting factors. EPS and psychopathology were assessed in 571 subjects with schizophrenia before (baseline) and after 4-year follow-up. Patients underwent treatment with SGA and/or FGA according to the referring clinicians' judgment. Relationships between EPS and psychopathology were assessed by network analysis, while a linear multiple regression investigated factors correlated to the presence of EPS at follow-up. EPS were significantly more frequent in the FGA- than in the SGA-treated group, and patients with EPS presented a more severe psychopathology. Parkinsonism was directly and positively connected with poor emotional expression at baseline and with poor emotional expression and disorganization at follow-up. Over the 4-year follow-up, emergent EPS were more frequent in FGA-treated patients, while relieved EPS occurred more frequently in SGA-treated persons. The presence of EPS at follow-up was significantly associated with EPS at baseline, illness duration, antipsychotic generation and the daily dose of antipsychotic medications. After a 4-year naturalistic treatment, EPS disappeared more frequently in SGA-treated patients, while they emerged more frequently in FGA-treated individuals. Therefore, although SGA did not eliminate the risk of EPS, these drugs seem to be associated to a more favorable EPS natural evolution.

Published
2022

42. The Complex Interplay Between Physical Activity and Recovery Styles in Patients With Severe Mental Disorders in a Real-World Multicentric Study

Author

Sampogna, G, Luciano, M, Di Vincenzo, M, Andriola, I, D'Ambrosio, E, Amore, M, Serafini, G, Rossi, A, Carmassi, C, Dell'Osso, L, Di Lorenzo, G, Siracusano, A, Rossi, R, Fiorillo, A, Working Group LIFESTYLE, Bianciardi, E, Sampogna, Gaia, Luciano, Mario, Di Vincenzo, Matteo, Andriola, Ileana, D'Ambrosio, Enrico, Amore, Mario, Serafini, Gianluca, Rossi, Alessandro, Carmassi, Claudia, Dell'Osso, Liliana, Di Lorenzo, Giorgio, Siracusano, Alberto, Rossi, Rodolfo, and Fiorillo, Andrea

Subjects
Psychiatry and Mental health, lifestyle, sedentary behaviors, Settore MED/25, sedentary behavior, physical activity, severe mental disorders, mortality
Abstract

Compared with the general population, people with severe mental disorders have significantly worse physical health and a higher mortality rate, which is partially due to the adoption of unhealthy lifestyle behaviors, such as heavy smoking, use of alcohol or illicit drugs, unbalanced diet, and physical inactivity. These unhealthy behaviors may also play a significant role in the personal and functional recovery of patients with severe mental disorders, although this relationship has been rarely investigated in methodologically robust studies. In this paper, we aim to: a) describe the levels of physical activity and recovery style in a sample of patients with severe mental disorders; b) identify the clinical, social, and illness-related factors that predict the likelihood of patients performing physical activity. The global sample consists of 401 patients, with a main psychiatric diagnosis of bipolar disorder (43.4%, N = 174), psychosis spectrum disorder (29.7%; N = 119), or major depression (26.9%; N = 118). 29.4% (N = 119) of patients reported performing physical activity regularly, most frequently walking (52.1%, N = 62), going to the gym (21.8%, N = 26), and running (10.9%, N = 13). Only 15 patients (3.7%) performed at least 75 min of vigorous physical activity per week. 46.8% of patients adopted sealing over as a recovery style and 37.9% used a mixed style toward integration. Recovery style is influenced by gender (p < 0.05) and age (p < 0.05). The probability to practice regular physical activity is higher in patients with metabolic syndrome (Odds Ratio - OR: 2.1; Confidence Interval - CI 95%: 1.2-3.5; p < 0.050), and significantly lower in those with higher levels of anxiety/depressive symptoms (OR: 0.877; CI 95%: 0.771-0.998; p < 0.01). Globally, patients with severe mental disorders report low levels of physical activities, which are associated with poor recovery styles. Psychoeducational interventions aimed at increasing patients' motivation to adopt healthy lifestyle behaviors and modifying recovery styles may improve the physical health of people with severe mental disorders thus reducing the mortality rates.

Published
2022

43. The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study

Author

Eleonora Merlotti, Liliana Dell'Osso, Enrico Collantoni, Alice Ghiani, Paolo Stratta, Paola Rocca, Dino Gibertoni, Dario Cannavò, Alessandro Rossi, Alessandro Corso, Simone Bolognesi, Martino Belvedere Murri, Roberto Brugnoli, Cinzia Mingrone, Mario Altamura, Giorgio Di Lorenzo, Valeria Bianchini, Davide Gallicchio, Claudia Carmassi, Carmela Marucci, T. Acciavatti, Marina Mancini, Paola Bucci, Marco Alessandrini, M. Chieffi, A. Vignapiano, Giacomo Deste, Armida Mucci, Gaetano Callista, Mario Amore, Mario Maj, Cristiana Montemagni, Monicag Sigaudo, Stefania de Simone, Carla Gramaglia, Federica Vellante, Fabio Di Fabio, Antonio Vita, Andrea Cantisani, Pietro Calcagno, Chiara De Panfilis, Massimo Biondi, Tiziana Frieri, Arianna Goracci, Laura Giusti, Cinzia Niolu, Paola Rucci, Maria Salvina Signorelli, Stefano Porcelli, Luca Gheda, Bernardo Carpiniello, Alessandro Bertolino, Antonello Bellomo, Luca Bartoli, Alessandro Galluzzo, Rita Roncone, Maria Antonietta Nettis, Anna Comparelli, Valeria Santarelli, Andrea Fagiolini, Carlo Marchesi, Elena Tenconi, Ferdinando Diasco, Paolo Ossola, Valentina Corigliano, Alberto Siracusano, Palmiero Monteleone, Elisa Borghini, Antonella De Carolis, Federica Pinna, Carla Cremonese, Alice Lai, Maurizio Malavolta, Tiziana Pagano, Alessandro Feggi, Massimo Di Giannantonio, Alessia Maria Chiara Mirigliani Torti, Mariangela Rocco, Giuseppe Minutolo, Grazia Rutigliano, Giuseppe Rizzo, Giulio Corrivetti, Matteo Tonna, Patrizia Zeppegno, Flavia A. Padalino, Alfonso Troisi, Camilla Gesi, E. Gattoni, Simona D'Onofrio, Carmine Tomasetti, Ileana Andriola, Giuseppe Piegari, Silvana Galderisi, Eugenio Aguglia, Rossi, Alessandro, Galderisi, Silvana, Rocca, Paola, Bertolino, Alessandro, Mucci, Armida, Rucci, Paola, Gibertoni, Dino, Aguglia, Eugenio, Amore, Mario, Andriola, Ileana, Bellomo, Antonello, Biondi, Massimo, Callista, Gaetano, Comparelli, Anna, Dell’Osso, Liliana, Di Giannantonio, Massimo, Fagiolini, Andrea, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Niolu, Cinzia, Piegari, Giuseppe, Pinna, Federica, Roncone, Rita, Stratta, Paolo, Tenconi, Elena, Vita, Antonio, Zeppegno, Patrizia, Maj, Mario, Mancini, Marina, Nettis, Maria Antonietta, Rizzo, Giuseppe, Porcelli, Stefano, Deste, Giacomo, Galluzzo, Alessandro, Gheda, Luca, Carpiniello, Bernardo, Ghiani, Alice, Lai, Alice, Cannavò, Dario, Minutolo, Giuseppe, Signorelli, Maria Salvina, Acciavatti, Tiziano, Alessandrini, Marco, Vellante, Federica, Cantisani, Andrea, Altamura, Mario, Padalino, Flavia A., Pagano, Tiziana, Belvedere Murri, Martino, Calcagno, Pietro, Corso, Alessandro, D’Onofrio, Simona, Marucci, Carmela, Santarelli, Valeria, Bianchini, Valeria, Giusti, Laura, Malavolta, Maurizio, Bucci, Paola, Chieffi, Marcello, de Simone, Stefania, Merlotti, Eleonora, Rocco, Mariangela, Vignapiano, Annarita, Tomasetti, Carmine, Feggi, Alessandro, Gattoni, Eleonora, Gramaglia, Carla, Cremonese, Carla, Collantoni, Enrico, Gallicchio, Davide, de Panfilis, Chiara, Ossola, Paolo, Tonna, Matteo, Carmassi, Claudia, Gesi, Camilla, Rutigliano, Grazia, Brugnoli, Roberto, Corigliano, Valentina, de Carolis, Antonella, Di Fabio, Fabio, Mirigliani Torti, Alessia Maria Chiara, Di Lorenzo, Giorgio, Siracusano, Alberto, Troisi, Alfonso, Bartoli, Luca, Corrivetti, Giulio, Diasco, Ferdinando, Bolognesi, Simone, Borghini, Elisa, Goracci, Arianna, Frieri, Tiziana, Mingrone, Cinzia, Sigaudo, Monicag, and Sigaudo, Monica

Subjects
Male, Coping (psychology), Social stigma, Social Stigma, Severity of Illness Index, Symptom severity, Personal resource, Structural equation model, Psychosocial functioning, 0302 clinical medicine, Surveys and Questionnaires, Pharmacology (medical), Age of Onset, Antisocial Personality Disorder, General Medicine, Middle Aged, Italy, Psychiatry and Mental Health, Personal resources, Schizophrenia, Structural equation models, Biological Psychiatry, Female, Schizophrenic Psychology, Biological psychiatry, Psychology, Social Adjustment, Psychosocial, Clinical psychology, Adult, medicine.medical_specialty, Adolescent, macromolecular substances, Structural equation modeling, Young Adult, 03 medical and health sciences, Severity of illness, medicine, Humans, Psychiatry, Settore MED/25 - Psichiatria, Aged, Psychiatric Status Rating Scales, Antisocial personality disorder, Models, Theoretical, medicine.disease, Self Concept, 030227 psychiatry, Schizophrenia, Personal resources, Symptom severity, Psychosocial functioning, Structural equation models, Age of onset, 030217 neurology & neurosurgery
Abstract

The relationships of personal resources with symptom severity and psychosocial functioning have never been tested systematically in a large sample of people with schizophrenia. We applied structural equation models to a sample of 921 patients with schizophrenia collected in a nationwide Italian study, with the aim to identify, among a large set of personal resources, those that may have an association with symptom severity or psychosocial functioning. Several relevant demographic and clinical variables were considered concurrently. Poor service engagement and poor recovery style, as well as older age and younger age at onset, were related to greater symptom severity and poorer social functioning. Higher resilience and higher education were related to better social functioning only. Poor problem-focused coping and internalized stigma, as well as male gender and depression, were related to symptom severity only. The explored variables showed distinctive and partially independent associations with symptom severity and psychosocial functioning. A deeper understanding of these relationships may inform treatment decisions.

Published
2017

44. Does social cognition change? Evidence after 4 years from the Italian Network for Research on Psychoses.

Author

Rocca P, Rucci P, Montemagni C, Rossi A, Bertolino A, Aguglia E, Altamura CA, Amore M, Andriola I, Bellomo A, Brasso C, Carpiniello B, Del Favero E, Dell'Osso L, Di Fabio F, Fabrazzo M, Fagiolini A, Giordano GM, Marchesi C, Martinotti G, Monteleone P, Pompili M, Roncone R, Rossi R, Siracusano A, Tenconi E, Vita A, Zeppegno P, Galderisi S, and Maj M

Subjects
Humans, Social Cognition, Cognition, Social Perception, Psychotic Disorders diagnosis, Schizophrenia diagnosis
Abstract

Background: Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up., Methods: The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up., Results: In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery., Conclusions: The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.

Published
2023
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45. Using combined environmental-clinical classification models to predict role functioning outcome in clinical high-risk states for psychosis and recent-onset depression.

Author

Antonucci LA, Penzel N, Sanfelici R, Pigoni A, Kambeitz-Ilankovic L, Dwyer D, Ruef A, Sen Dong M, Öztürk ÖF, Chisholm K, Haidl T, Rosen M, Ferro A, Pergola G, Andriola I, Blasi G, Ruhrmann S, Schultze-Lutter F, Falkai P, Kambeitz J, Lencer R, Dannlowski U, Upthegrove R, Salokangas RKR, Pantelis C, Meisenzahl E, Wood SJ, Brambilla P, Borgwardt S, Bertolino A, and Koutsouleris N

Abstract

Background: Clinical high-risk states for psychosis (CHR) are associated with functional impairments and depressive disorders. A previous PRONIA study predicted social functioning in CHR and recent-onset depression (ROD) based on structural magnetic resonance imaging (sMRI) and clinical data. However, the combination of these domains did not lead to accurate role functioning prediction, calling for the investigation of additional risk dimensions. Role functioning may be more strongly associated with environmental adverse events than social functioning., Aims: We aimed to predict role functioning in CHR, ROD and transdiagnostically, by adding environmental adverse events-related variables to clinical and sMRI data domains within the PRONIA sample., Method: Baseline clinical, environmental and sMRI data collected in 92 CHR and 95 ROD samples were trained to predict lower versus higher follow-up role functioning, using support vector classification and mixed k-fold/leave-site-out cross-validation. We built separate predictions for each domain, created multimodal predictions and validated them in independent cohorts (74 CHR, 66 ROD)., Results: Models combining clinical and environmental data predicted role outcome in discovery and replication samples of CHR (balanced accuracies: 65.4% and 67.7%, respectively), ROD (balanced accuracies: 58.9% and 62.5%, respectively), and transdiagnostically (balanced accuracies: 62.4% and 68.2%, respectively). The most reliable environmental features for role outcome prediction were adult environmental adjustment, childhood trauma in CHR and childhood environmental adjustment in ROD., Conclusions: Findings support the hypothesis that environmental variables inform role outcome prediction, highlight the existence of both transdiagnostic and syndrome-specific predictive environmental adverse events, and emphasise the importance of implementing real-world models by measuring multiple risk dimensions.

Published
2022
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46. [Lifestyle in patients with severe mental disorders: a new target for psychosocial interventions?]

Author

Sampogna G, Luciano M, Del Vecchio V, Giallonardo V, Palummo C, Andriola I, Sangiuliano M, Calcagno P, Zampogna D, Rossi R, Stratta P, Carmassi C, Dell'Osso L, Niolu C, Siracusano A, and Fiorillo A

Subjects
Adult, Female, Humans, Life Style, Middle Aged, Psychosocial Intervention, Bipolar Disorder epidemiology, Bipolar Disorder therapy, Mental Disorders epidemiology, Mental Disorders therapy, Schizophrenia epidemiology, Schizophrenia therapy
Abstract

Introduction: Patients with severe mental disorders (namely schizophrenia, major depression and bipolar disorder) have a reduced life expectancy of at least 10 to 25 years compared with the general population. This mortality gap is due to the higher prevalence of comorbid physical disorders (such as diabetes, hypertension and cardiovascular diseases) in these patients compared to the general population. Factors contributing to the mortality gap include lack of access to primary care services, severity of clinical symptoms, internalized stigma and discrimination by healthcare professionals, pharmacological treatments and unhealthy lifestyle behaviours. Several international studies have highlighted the high prevalence of unhealthy lifestyle behaviours in patients with severe mental disorders, but a few data are available from Italian real-world settings., Aim: The present study aims to: 1) describe the lifestyle behaviours adopted by a sample of real-world patients affected by severe mental disorders; 2) identify differences in lifestyle behaviours according to diagnostic category., Materials: The final sample consisted of 402 patients, mainly female (57%), with a mean age of 45.8±11.8 years. 35% of them suffers from moderate obesity and 40% of them is affected by hyperinsulinemia, hypercolestereloemia and hypertrygliceridemia. 70% of patients has sedentary behaviours. Moderate to severe nicotine dependence is reported by 42% of patients. Patients with bipolar disorders are more frequently smokers compared to other patients. No significant differences in lifestyle behaviours have been found among the three diagnostic groups., Results and Conclusions: Our data confirm that patients with severe mental disorders adopt unhealthy lifestyle behaviours, regardless their diagnosis. New psychosocial interventions, including motivational and psychoeducational components and targeting lifestyle behaviours, should be developed and disseminated in order to reduce the mortality gap.

Published
2021
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