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4 results on '"Andriniaina Nkili-Meyong"'

1. Identity and nature of neural stem cells in the adult human subventricular zone

Author

Salma Baig, Javad Nadaf, Redouane Allache, Phuong U. Le, Michael Luo, Annisa Djedid, Andriniaina Nkili-Meyong, Maryam Safisamghabadi, Alex Prat, Jack Antel, Marie-Christine Guiot, and Kevin Petrecca

Subjects
Molecular biology, Cell biology, Omics, Transcriptomics, Science
Abstract

Summary: The existence of neural stem cells (NSCs) in adult human brain neurogenic regions remains unresolved. To address this, we created a cell atlas of the adult human subventricular zone (SVZ) derived from fresh neurosurgical samples using single-cell transcriptomics. We discovered 2 adult radial glia (RG)-like populations, aRG1 and aRG2. aRG1 shared features with fetal early RG (eRG) and aRG2 were transcriptomically similar to fetal outer RG (oRG). We also captured early neuronal and oligodendrocytic NSC states. We found that the biological programs driven by their transcriptomes support their roles as early lineage NSCs. Finally, we show that these NSCs have the potential to transition between states and along lineage trajectories. These data reveal that multipotent NSCs reside in the adult human SVZ.

Published
2024
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2. Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells

Author

Charles P, Couturier, Javad, Nadaf, Zhaorong, Li, Salma, Baig, Gabriele, Riva, Phuong, Le, Daan J, Kloosterman, Jean, Monlong, Andriniaina, Nkili Meyong, Redouane, Allache, Theresa, Degenhard, Mariam, Al-Rashid, Marie-Christine, Guiot, Guillaume, Bourque, Jiannis, Ragoussis, Leila, Akkari, Francisco J, Quintana, and Kevin, Petrecca

Subjects
Cancer Research, Neural Stem Cells, Oncology, Brain Neoplasms, Lateral Ventricles, Basic and Translational Investigations, Tumor Microenvironment, Humans, Neurology (clinical), Single-Cell Analysis, Glioblastoma, nervous system diseases
Abstract

Background Glioblastoma is a treatment-resistant brain cancer. Its hierarchical cellular nature and its tumor microenvironment (TME) before, during, and after treatments remain unresolved. Methods Here, we used single-cell RNA sequencing to analyze new and recurrent glioblastoma and the nearby subventricular zone (SVZ). Results We found 4 glioblastoma neural lineages are present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences. Cancer lineages were hierarchically organized around cycling oligodendrocytic and astrocytic progenitors that are transcriptomically similar but distinct to SVZ neural stem cells (NSCs). Furthermore, NSCs from the SVZ of patients with glioblastoma harbored glioblastoma chromosomal anomalies. Lastly, mesenchymal cancer cells and TME reactive astrocytes shared similar gene signatures which were induced by radiotherapy in a myeloid-dependent fashion in vivo. Conclusion These data reveal the dynamic, immune-dependent nature of glioblastoma’s response to treatments and identify distant NSCs as likely cells of origin.

Published
2022

3. Additional file 1: Table S1. of Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugolâ s iodine (VIA/VILI) in Libreville, Gabon

Author

Moussavou, Pamela, IsmaĂŤl Koumakpayi, Andriniaina Nkili-Meyong, Labouba, Ingrid, Bisvigou, Ulrich, Junie Chansi, Engohan-Aloghe, Corinne, Dissanami, Frederic, Ambounda, Nathalie, Anne-Sophie Delannoy-Vieillard, Diancourt, Laure, Dieudonne Nkoghe, Leroy, Eric, Belembaogo, Ernest, and Berthet, Nicolas

Abstract

List of PCR primers sequences used. Table S2. Identified HPV genotypes per samples. (DOCX 287Â kb)

Published
2016
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