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3. Le rôle des lymphocytes T résidents mémoires dans les myosites induites par les inhibiteurs de point de contrôle immunitaire

Author

Dal Cin, J., primary, Anquetil, C., additional, Touat, M., additional, Léonard-Louis, S., additional, Andrieu, M., additional, Letourneur, F., additional, Amelin, D., additional, Tendrel, B., additional, Chenane, L., additional, Chassepot, H., additional, Psimaras, D., additional, Bretagne, M.C., additional, Rigolet, A., additional, Champtiaux, N., additional, Daniel, P., additional, Wesner, N., additional, Rosenzwajg, M., additional, Benveniste, O., additional, Salem, J.E., additional, and Allenbach, Y., additional

Published
2023
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4. Caractérisation du microenvironnement des cancers de la surrénale par transcriptome single-cell

Author

Jouinot, A., primary, Martin, Y., additional, Foulonneau, T., additional, Bendjelal, Y., additional, Calvet, P., additional, Violon, F., additional, Sibony, M., additional, De Murat, D., additional, Armignacco, R., additional, Perlemoine, K., additional, Letourneur, F., additional, Izac, B., additional, Andrieu, M., additional, Berthon, A., additional, Ragazzon, B., additional, Haissaguerre, M., additional, Tabarin, A., additional, Groussin, L., additional, Libe, R., additional, Bertherat, J., additional, and Assie, G., additional

Published
2023
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7. Ultra-sensitive troponin-I and incident coronary heart disease, stroke, heart failure, cardiac arrhythmias, arterial aneurysms and venous thromboembolism hospitalizations

Author

Empana, J P, primary, Lerner, I, additional, Perier, M C, additional, Jabre, P, additional, Andrieu, M, additional, Climie, R E, additional, Van Sloten, T, additional, Vedie, B, additional, Geromin, D, additional, Marijon, E, additional, Danchin, N, additional, Thomas, F, additional, Boutouyrie, P, additional, and Jouven, X, additional

Published
2022
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9. Oral Condition and Incident Coronary Heart Disease: A Clustering Analysis

Author

Deraz, O., Deraz, O., Range, H., Boutouyrie, P., Chatzopoulou, E., Asselin, A., Guibout, C., Van Sloten, T., Bougouin, W., Andrieu, M., Vedie, B., Thomas, F., Danchin, N., Jouven, X., Bouchard, P., Empana, J.P., Deraz, O., Deraz, O., Range, H., Boutouyrie, P., Chatzopoulou, E., Asselin, A., Guibout, C., Van Sloten, T., Bougouin, W., Andrieu, M., Vedie, B., Thomas, F., Danchin, N., Jouven, X., Bouchard, P., and Empana, J.P.

Abstract

Poor oral health has been linked to coronary heart disease (CHD). Clustering clinical oral conditions routinely recorded in adults may identify their CHD risk profile. Participants from the Paris Prospective Study 3 received, between 2008 and 2012, a baseline routine full-mouth clinical examination and an extensive physical examination and were thereafter followed up every 2 y until September 2020. Three axes defined oral health conditions: 1) healthy, missing, filled, and decayed teeth; 2) masticatory capacity denoted by functional masticatory units; and 3) gingival inflammation and dental plaque. Hierarchical cluster analysis was performed with multivariate Cox proportional hazards regression models and adjusted for age, sex, smoking, body mass index, education, deprivation (EPICES score; Evaluation of Deprivation and Inequalities in Health Examination Centres), hypertension, type 2 diabetes, LDL and HDL serum cholesterol (low- and high-density lipoprotein), triglycerides, lipid-lowering medications, NT-proBNP and IL-6 serum level. A sample of 5,294 participants (age, 50 to 75 y; 37.10% women) were included in the study. Cluster analysis identified 3,688 (69.66%) participants with optimal oral health and preserved masticatory capacity (cluster 1), 1,356 (25.61%) with moderate oral health and moderately impaired masticatory capacity (cluster 2), and 250 (4.72%) with poor oral health and severely impaired masticatory capacity (cluster 3). After a median follow-up of 8.32 y (interquartile range, 8.00 to 10.05), 128 nonfatal incident CHD events occurred. As compared with cluster 1, the risk of CHD progressively increased from cluster 2 (hazard ratio, 1.45; 95% CI, 0.98 to 2.15) to cluster 3 (hazard ratio, 2.47; 95% CI, 1.34 to 4.57; P < 0.05 for trend). To conclude, middle-aged individuals with poor oral health and severely impaired masticatory capacity have more than twice the risk of incident CHD than those with optimal oral health and preserved masticatory capac

Published
2022

11. Oral Condition and Incident Coronary Heart Disease: A Clustering Analysis

Author

Deraz, O., primary, Rangé, H., additional, Boutouyrie, P., additional, Chatzopoulou, E., additional, Asselin, A., additional, Guibout, C., additional, Van Sloten, T., additional, Bougouin, W., additional, Andrieu, M., additional, Vedié, B., additional, Thomas, F., additional, Danchin, N., additional, Jouven, X., additional, Bouchard, P., additional, and Empana, J.P., additional

Published
2021
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12. sj-docx-1-jdr-10.1177_00220345211052507 ��� Supplemental material for Oral Condition and Incident Coronary Heart Disease: A Clustering Analysis

Author

Deraz, O., Rang��, H., Boutouyrie, P., Chatzopoulou, E., Asselin, A., Guibout, C., Van Sloten, T., Bougouin, W., Andrieu, M., Vedi��, B., Thomas, F., Danchin, N., Jouven, X., Bouchard, P., and Empana, J.P.

Subjects
110599 Dentistry not elsewhere classified, FOS: Materials engineering, FOS: Clinical medicine, 91299 Materials Engineering not elsewhere classified
Abstract

Supplemental material, sj-docx-1-jdr-10.1177_00220345211052507 for Oral Condition and Incident Coronary Heart Disease: A Clustering Analysis by O. Deraz, H. Rang��, P. Boutouyrie, E. Chatzopoulou, A. Asselin, C. Guibout, T. Van Sloten, W. Bougouin, M. Andrieu, B. Vedi��, F. Thomas, N. Danchin, X. Jouven, P. Bouchard and J.P. Empana in Journal of Dental Research

Published
2021
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13. L’atlas transcriptome single-cell des cancers de la surrénale identifie des « écotypes » tumoraux associés à la survie

Author

Jouinot, A., Martin, Y., Foulonneau, T., Bendjelal, Y., Violon, F., Calvet, P., Izac, B., Letourneur, F., Bertholle, C., Andrieu, M., Onifarasoaniaina, R., Favier, M., De Guitaut, C., Fraikin, A., De Murat, D., Armignacco, R., Benanteur, N., Sibony, M., Perlemoine, K., Vaduva, P., Bouys, L., Bonnet Serrano, F., Dousset, B., Gaillard, M., Pasmant, E., Barat, M., Dohan, A., Haissaguerre, M., Tabarin, A., Libe, R., Guignat, L., Groussin, L., Berthon, A., Ragazzon, B., Bertherat, J., and Assie, G.

Abstract

La classification transcriptome sépare les tumeurs bénignes (cluster « C2 ») des corticosurrénalomes et identifie deux groupes de corticosurrénalomes, « C1A » (signature stéroïde et prolifération), de mauvais pronostic, et « C1B » (signature immune), de pronostic bien meilleur. Ces signatures étant définies à l’échelle du tissu (« bulk »), la composition et le rôle du microenvironnement tumoral restent peu connus. L’objectif de cette étude est de réaliser l’atlas cellulaire des corticosurrénalomes.

Published
2024
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14. An integrated fruit model toolkit: combining fruit biophysical processes with central carbon metabolism

Author

Chen, J.L., primary, Beauvoit, B., additional, Colombié, S., additional, Roch, L., additional, Cakpo, C.B., additional, Vercambre, G., additional, Génard, M., additional, Andrieu, M.-H., additional, Jacob, D., additional, Girollet, N., additional, Moing, A., additional, Gomès, E., additional, Gibon, Y., additional, and Dai, Z.W., additional

Published
2020
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16. Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism

Author

Flament, H., primary, Rouland, M., additional, Beaudoin, L., additional, Toubal, A., additional, Bertrand, L., additional, Lebourgeois, S., additional, Gouda, Z., additional, Rousseau, C., additional, Soulard, P., additional, Hurtado-Nedelec, M., additional, Luce, S., additional, Bailly, K., additional, Andrieu, M., additional, Boitard, C., additional, Vallet-Pichard, A., additional, Gautier, JF., additional, Ajzenberg, N., additional, Terrier, B., additional, Pene, F., additional, Ghosn, J., additional, Yazdanpanah, Y., additional, Visseaux, B., additional, Descamps, D., additional, Timsit, JF., additional, Monteiro, R.C., additional, and Lehuen, A., additional

Published
2020
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23. Nouveaux ensembles céramiques augusto-tibériens découverts à Autun (71). Le site du 17B, rue Carion

Author

Labaune, Yannick, Saggese, Adrien, Andrieu, M., Desbois-Garcia, Sophie, Archéologie, Terre, Histoire, Sociétés [Dijon] ( ARTeHiS ), Ministère de la Culture et de la Communication ( MCC ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Archéologie, Terre, Histoire, Sociétés [Dijon] (ARTeHiS), and Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Ministère de la Culture et de la Communication (MCC)

Subjects
[SHS.ARCHEO] Humanities and Social Sciences/Archaeology and Prehistory, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Archéologie, [ SHS.ARCHEO ] Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

25. IL-12 producing monocytes and IFN-gamma and TNF-alpha producing T-lymphocytes are increased in placentas infected by Plasmodium falciparum

Author

Diouf, Ibrahima, Fievet, Nadine, Doucouré, Souleymane, Ngom, Mamadou, Andrieu, M., Mathieu, J. F., Gaye, A., Thiaw, O. T., and Deloron, Philippe

Subjects
placenta, INF gamma, Plasmodium falciparum, malaria, pregnancy, IL 2, TNF alpha
Abstract

Placental Plasmodium falciparum sequestration is associated with dysregulated immune function. Placental inflammatory responses via IFN-gamma and TNF-alpha are implicated in functional damage. However, they are needed during placental infection to control asexual stage parasites. To test the hypothesis that placental immunomodulation associated with malaria disturbs cytokine secretion differently in monocytes and lymphocytes, we have determined the proportion of monocytes and/or lymphocytes secreting IFN-gamma, TNF-alpha, IL-10 and IL-12. Intervillous and peripheral blood monocyte (CD14(+)) and lymphocyte (CD3/CD4(+); CD3/CD8(+)) cytokine production was compared between 17 P. falciparum-infected and 12 non-infected Senegalese women. After culture with phorbolmyristate acetate/ionomycin (PMA/iono), lipopolysaccharide (LPS) or P. falciparum-infected erythrocytes (IE), the intracellular expression of cytokines in lymphocytes (IFN-gamma, TNF-alpha) and monocytes (IL-10, IL-12, TNF-alpha), was detected. In response to IE, CD4(+) and CD8(+) T-cells produced IFN-gamma and TNF-alpha at similar rates in both compartments. In response to PMA/iono, the frequencies of CD4(+) and CD8(+) T-cells producing IFN-gamma and TNF-alpha were similar in both compartments, but increased in P. falciparum-infected placentas. In response to LPS or IE, IL-12 secreting monocytes were increased in infected women, while the frequency of TNF-alpha secreting monocytes was decreased compared to that in non-infected placenta. The monocyte IL-12 response is not impaired in infected women. IL- 12 is an important factor for inducing IFN-gamma in T-cells. Thus, 1L-12 and IFN-alpha responses may synergistically allow a protective immune response in placental malaria. TNF-alpha production by CD4(+) and CD8(+) T-cells, is up-regulated in P falciparum-infected placentas, suggesting that T-cells actively participate to inflammatory responses.

Published
2007

34. Melatonin prevents inflammation and oxidative stress caused by abdominopelvic and total body irradiation of rat small intestine

Author

Guney, Y., primary, Hicsonmez, A., additional, Uluoglu, C., additional, Guney, H.Z., additional, Ozel Turkcu, U., additional, Take, G., additional, Yucel, B., additional, Caglar, G., additional, Bilgihan, A., additional, Erdogan, D., additional, Nalca Andrieu, M., additional, Kurtman, C., additional, and Zengil, H., additional

Published
2007
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39. CA46 - Mise au point d’une technique permettant d’optimiser la détection de la réplication du virus de l’hépatite C

Author

Carrière, M., primary, Breiman, A., additional, Pène, V., additional, Conti, F., additional, Chouzenoux, S., additional, Andrieu, M., additional, Jaffray, P., additional, Grira, L., additional, Soubrane, O., additional, Sogni, P., additional, Calmus, Y., additional, Chaussade, S., additional, Rosenberg, A.R., additional, and Podevin, P., additional

Published
2005
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48. A new pattern of non-organ- and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5

Author

Labro, M T, Andrieu, M C, Weber, M, and Homberg, J C

Subjects
Adult, Male, Kidney Cortex, Fluorescent Antibody Technique, Haplorhini, Middle Aged, Antibodies, Mitochondria, Rats, Organoids, Kidney Tubules, Antibody Specificity, Animals, Humans, Lupus Erythematosus, Systemic, Female, Anemia, Hemolytic, Autoimmune, Child, Research Article, Aged
Abstract

About 0.1% of the sera in human pathology produce a peculiar, cytoplasmic, non-organ- and non-species-specific fluorescence. This may easily be differentiated from the already described anti-organelle antibodies and, more particularly, from the mitochondrial antibodies of primary biliary cirrhosis. Should rat tissues be used in the immunofluorescence test, fluorescence predominates over the first two portions of the renal proximal tubules (P1 and P2) and the mucous neck cells of the stomach. This pattern may be atrributed to mitochondria, and in particular to their inner membranes by fluorescent staining of the ellipsoid region of the rods and cones of the eyes, and by absorption with purified organelles. To distinguish this antibody from the already described mitochondrial antibodies, this one will be called mitochondrial antibody number 5 (M5). The seven carriers of this antibody suffer from systemic lupus erythematosus or autoimmune haemolytic anaemia. In these cases no diseases of the liver were observed, contrary to other classical mitochondrial antibodies.

Published
1978

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