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4. Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT

Author

Pickard, R, Goulao, B, Carnell, S, Shen, J, MacLennan, G, Norrie, J, Breckons, M, Vale, L, Whybrow, P, Rapley, T, Forbes, R, Currer, S, Forrest, M, Wilkinson, J, McColl, E, Andrich, D, Barclay, S, Cook, J, Mundy, A, N'Dow, J, Payne, S, and Watkin, N

Subjects
Male, Technology Assessment, Biomedical, Urethrotomy, Urethral stricture, Cost-Benefit Analysis, medicine.medical_treatment, 030232 urology & nephrology, health status, urethrotomy, State Medicine, law.invention, 0302 clinical medicine, Randomized controlled trial, law, lower urinary tract symptoms, 030212 general & internal medicine, bulbar urethral stricture, Health Policy, Hazard ratio, cost-effectiveness analysis, Cost-effectiveness analysis, Middle Aged, outcome assessment qualitative process evaluation, Models, Economic, lcsh:R855-855.5, Quality-Adjusted Life Years, Research Article, urethroplasty, Adult, medicine.medical_specialty, recurrence, lcsh:Medical technology, Urologic Surgical Procedures, Male, Urethroplasty, Interviews as Topic, 03 medical and health sciences, Lower urinary tract symptoms, medicine, Humans, Aged, Urethral Stricture, business.industry, Endoscopy, A300, medicine.disease, United Kingdom, Surgery, Quality of Life, business, randomised controlled trial, Bulbar urethral stricture
Abstract

Background Men who suffer recurrence of bulbar urethral stricture have to decide between endoscopic urethrotomy and open urethroplasty to manage their urinary symptoms. Evidence of relative clinical effectiveness and cost-effectiveness is lacking. Objectives To assess benefit, harms and cost-effectiveness of open urethroplasty compared with endoscopic urethrotomy as treatment for recurrent urethral stricture in men. Design Parallel-group, open-label, patient-randomised trial of allocated intervention with 6-monthly follow-ups over 24 months. Target sample size was 210 participants providing outcome data. Participants, clinicians and local research staff could not be blinded to allocation. Central trial staff were blinded when needed. Setting UK NHS with recruitment from 38 hospital sites. Participants A total of 222 men requiring operative treatment for recurrence of bulbar urethral stricture who had received at least one previous intervention for stricture. Interventions A centralised randomisation system using random blocks allocated participants 1 : 1 to open urethroplasty (experimental group) or endoscopic urethrotomy (control group). Main outcome measures The primary clinical outcome was control of urinary symptoms. Cost-effectiveness was assessed by cost per quality-adjusted life-year (QALY) gained over 24 months. The main secondary outcome was the need for reintervention for stricture recurrence. Results The mean difference in the area under the curve of repeated measurement of voiding symptoms scored from 0 (no symptoms) to 24 (severe symptoms) between the two groups was –0.36 [95% confidence interval (CI) –1.78 to 1.02; p = 0.6]. Mean voiding symptom scores improved between baseline and 24 months after randomisation from 13.4 [standard deviation (SD) 4.5] to 6 (SD 5.5) for urethroplasty group and from 13.2 (SD 4.7) to 6.4 (SD 5.3) for urethrotomy. Reintervention was less frequent and occurred earlier in the urethroplasty group (hazard ratio 0.52, 95% CI 0.31 to 0.89; p = 0.02). There were two postoperative complications requiring reinterventions in the group that received urethroplasty and five, including one death from pulmonary embolism, in the group that received urethrotomy. Over 24 months, urethroplasty cost on average more than urethrotomy (cost difference £2148, 95% CI £689 to £3606) and resulted in a similar number of QALYs (QALY difference –0.01, 95% CI –0.17 to 0.14). Therefore, based on current evidence, urethrotomy is considered to be cost-effective. Limitations We were able to include only 69 (63%) of the 109 men allocated to urethroplasty and 90 (80%) of the 113 men allocated to urethrotomy in the primary complete-case intention-to-treat analysis. Conclusions The similar magnitude of symptom improvement seen for the two procedures over 24 months of follow-up shows that both provide effective symptom control. The lower likelihood of further intervention favours urethroplasty, but this had a higher cost over the 24 months of follow-up and was unlikely to be considered cost-effective. Future work Formulate methods to incorporate short-term disutility data into cost-effectiveness analysis. Survey pathways of care for men with urethral stricture, including the use of enhanced recovery after urethroplasty. Establish a pragmatic follow-up schedule to allow national audit of outcomes following urethral surgery with linkage to NHS Hospital Episode Statistics. Trial registration Current Controlled Trials ISRCTN98009168. Funding This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 24, No. 61. See the NIHR Journals Library website for further project information.

Published
2020

11. The logistical management of tertiary urethral disease in the United Kingdom: Implications from an online audit of male reconstructive urethral surgery

Author

Payne, Stephen R, primary, Fowler, Sarah, additional, Mundy, Anthony R, additional, Alhasso, A., additional, Almallah, Y., additional, Anderson, P., additional, Andrich, D., additional, Baird, A., additional, Biers, S., additional, Browning, A., additional, Chapple, C., additional, Cherian, J., additional, Clarke, L., additional, Conn, I., additional, Dickerson, D., additional, Doble, A., additional, Dorkin, T., additional, Duggan, B., additional, Eardley, I., additional, Garaffa, G., additional, Greenwell, T., additional, Hadway, P., additional, Harding, C., additional, Hilmy, M., additional, Inman, R., additional, Kayes, O., additional, Kirchin, V., additional, Krishnan, R., additional, Kumar, V., additional, Lemberger, J., additional, Malone, P., additional, Moore, J., additional, Moore, K., additional, Mundy, A., additional, Noble, J., additional, Nurse, D., additional, Palmer, M., additional, Payne, S., additional, Pickard, R., additional, Rai, J., additional, Rees, R., additional, Roux, J., additional, Seipp, C., additional, Shabbir, M., additional, Saxby, M., additional, Sharma, D., additional, Sinclair, A., additional, Summerton, D., additional, Tatarov, O., additional, Thiruchelvam, N., additional, Venn, S, additional, Watkin, N., additional, and Zacherakis, E., additional

Published
2020
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26. Surgical treatment for recurrent bulbar urethral stricture: A randomised open label superiority trial of open urethroplasty versus endoscopic urethrotomy (The OPEN Trial)

Author

Goulao, B., primary, Carnell, S., additional, Shen, J., additional, MacLennan, G., additional, Norrie, J., additional, Cook, J., additional, McColl, E., additional, Breckons, M., additional, Vale, L., additional, Forbes, R., additional, Currer, S., additional, Forrest, M., additional, Wilkinson, J., additional, Andrich, D., additional, Barclay, S., additional, Munday, A., additional, N’Dow, J., additional, Payne, S., additional, Watkin, N., additional, and Pickard, R., additional

Published
2019
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47. BÄRLIN2014-Kampagne: Messung des Vegetationseinflusses auf Luftqualität und Feinstaubbelastung in Berlin

Author

Bonn, B., Schneidemesser, E.Von, Schmale, J., Andrich, D., Quedenau, J., Nothard, R., Stülpnagel, A.Von, Kerschbaumer, A., Schäfer, K., Junkermann, W., Grote, R., Gerwig, H., Kura, J., Pietsch, A., Lüdecke, A., Klemp, D., Ehlers, C., Hellen, H., Hakola, H., Leigh, R., Peterson, P., Frenzel, W., Butler, T., Lauer, A., Churkina, G., and Lawrence, M.G.

Subjects
Earth sciences, ddc:550
Published
2015

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