Search

Your search keyword '"Andrey Anokhin"' showing total 8 results
Start Over Author "Andrey Anokhin"
8 results on '"Andrey Anokhin"'

1. Measuring retention within the adolescent brain cognitive development (ABCD)SM study

Author

Sarah W. Feldstein Ewing, Genevieve F. Dash, Wesley K. Thompson, Chase Reuter, Vanessa G. Diaz, Andrey Anokhin, Linda Chang, Linda B. Cottler, Gayathri J. Dowling, Kimberly LeBlanc, Robert A. Zucker, Susan F. Tapert, Sandra A. Brown, and Hugh Garavan

Subjects
ABCD study®, Adolescents, Retention, Metrics, Longitudinal studies, Neurophysiology and neuropsychology, QP351-495
Abstract

The Adolescent Brain Cognitive Development (ABCD)SM study aims to retain a demographically diverse sample of youth and one parent across 21 sites throughout its 10-year protocol while minimizing selective (systematic) attrition. To evaluate the effectiveness of these efforts, the ABCD Retention Workgroup (RW) has employed a data-driven approach to examine, track, and intervene via three key metrics: (1) which youth completed visits late; (2) which youth missed visits; and (3) which youth withdrew from the study. The RW actively examines demographic (race, education level, family income) and site factors (visit satisfaction, distance from site, and enrollment in ancillary studies) to strategize efforts that will minimize disengagement and loss of participating youth and parents. Data showed that the most robust primary correlates of late visits were distance from study site, race, and parental education level. Race, lower parental education level, parental employment status, and lower family income were associated with higher odds of missed visits, while being enrolled in one of the ancillary studies was associated with lower odds of missed visits. Additionally, parents who were primary Spanish speakers withdrew at slightly higher rates. These findings provide insight into future targets for proactive retention efforts by the ABCD RW.

Published
2022
Full Text
View/download PDF

2. Pathways to post‐traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults

Author

Stacey Subbie‐Saenz de Viteri, Ashwini Pandey, Gayathri Pandey, Chella Kamarajan, Rebecca Smith, Andrey Anokhin, Lance Bauer, Annah Bender, Grace Chan, Danielle Dick, Howard Edenberg, Sivan Kinreich, John Kramer, Marc Schuckit, Yong Zang, Vivia McCutcheon, Kathleen Bucholz, Bernice Porjesz, and Jacquelyn L. Meyers

Subjects
alcoholism, executive function, post‐traumatic stress disorder, trauma, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Introduction Family history (FH) of alcohol dependence is likely to increase the risk of trauma exposure, post‐traumatic stress disorder (PTSD), and alcohol dependence. FH of alcohol dependence and trauma has been separately shown to adversely affect planning/problem‐solving aspects of executive function. However, few studies have examined these risk factors in an integrated model. Methods Using data from trauma‐exposed individuals from the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 1,860), comprising offspring from alcohol‐dependent high‐risk and comparison families (mean age [SE] = 21.9 [4.2]), we investigated associations of trauma (nonsexual assaultive, nonassaultive, sexual assaultive) with DSM‐IV PTSD and alcohol dependence symptom counts, and planning/problem‐solving abilities assessed using the Tower of London Test (TOLT). Moderating effects of family history density of alcohol use disorder (FHD) on these associations and sex differences were explored. Results Family history density was positively associated with PTSD in female participants who endorsed a sexual assaultive trauma. Exposure to nonsexual assaultive trauma was associated with more excess moves made on the TOLT. Conclusion Findings from this study demonstrate associations with PTSD and alcohol dependence symptom counts, as well as poor problem‐solving ability in trauma‐exposed individuals from families densely affected with alcohol dependence, depending on trauma type, FHD, and sex. This suggests that having a FH of alcohol dependence and exposure to trauma during adolescence may be associated with more PTSD and alcohol dependence symptoms, and poor problem‐solving abilities in adulthood.

Published
2020
Full Text
View/download PDF

3. Associations of parent–adolescent closeness with <scp>P3</scp> amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder

Author

Gayathri Pandey, Sally I‐Chun Kuo, Kristina A. Horne‐Osipenko, Ashwini K. Pandey, Chella Kamarajan, Stacey Saenz de Viteri, Sivan Kinreich, David B. Chorlian, Weipeng Kuang, Mallory Stephenson, John Kramer, Andrey Anokhin, Yong Zang, Samuel Kuperman, Victor Hesselbrock, Marc Schuckit, Danielle Dick, Grace Chan, Vivia V. McCutcheon, Howard Edenberg, Kathleen K. Bucholz, Jacquelyn L. Meyers, and Bernice Porjesz

Subjects
Psychiatry and Mental health, Medicine (miscellaneous), Toxicology
Published
2023

4. Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts

Author

Yuye Huang, Eco J. C. de Geus, Danielle M. Dick, Daniel E. Gustavson, John R. Kramer, Lea K. Davis, Abraham A. Palmer, Toni-Kim Clarke, Dongbing Lai, Andrew D. Grotzinger, Dorret I. Boomsma, Kathryn Paige Harden, Michel G. Nivard, Travis T. Mallard, Ashwini K. Pandey, Emma C. Johnson, Andrey Anokhin, Jouke J. Hottenga, Jacquelyn L. Meyers, Arpana Agrawal, Alexis C. Edwards, Sandra Sanchez-Roige, Mariela V Jennings, Howard J. Edenberg, Jeanne E. Savage, Complex Trait Genetics, Amsterdam Neuroscience - Complex Trait Genetics, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, and APH - Methodology

Subjects
medicine.medical_specialty, Alcohol Drinking, Alcohol, Genome-wide association study, Population based, Alcohol use disorder, Cardiovascular, Medical and Health Sciences, Oral and gastrointestinal, chemistry.chemical_compound, Alcohol Use and Health, Substance Misuse, SDG 3 - Good Health and Well-being, medicine, Genetics, Genomic Structural Equation Modeling, Humans, GWAS, Psychiatry, Genetic association, Alcohol Use Disorders Identification Test, Alcohol Consumption, business.industry, Substance-Related and Addictive Disorders, Prevention, Human Genome, Psychology and Cognitive Sciences, ALSPAC, medicine.disease, Brain Disorders, Psychiatry and Mental health, Alcoholism, Mental Health, Good Health and Well Being, chemistry, business, Alcohol consumption, Genome-Wide Association Study
Abstract

OBJECTIVE: Genome-wide association studies (GWASs) of the Alcohol Use Disorders Identification Test (AUDIT), a 10-item screen for alcohol use disorder (AUD), have elucidated novel loci for alcohol consumption and misuse. However, these studies also revealed that GWASs can be influenced by numerous biases (e.g., measurement error, selection bias), which may have led to inconsistent genetic correlations between alcohol involvement and AUD, as well as paradoxically negative genetic correlations between alcohol involvement and psychiatric disorders and/or medical conditions. The authors used genomic structural equation modeling to elucidate the genetics of alcohol consumption and problematic consequences of alcohol use as measured by AUDIT. METHODS: To explore these unexpected differences in genetic correlations, the authors conducted the first item-level and the largest GWAS of AUDIT items (N=160,824) and applied a multivariate framework to mitigate previous biases. RESULTS: The authors identified novel patterns of similarity (and dissimilarity) among the AUDIT items and found evidence of a correlated two-factor structure at the genetic level ("consumption" and "problems," rg=0.80). Moreover, by applying empirically derived weights to each of the AUDIT items, the authors constructed an aggregate measure of alcohol consumption that was strongly associated with alcohol dependence (rg=0.67), moderately associated with several other psychiatric disorders, and no longer positively associated with health and positive socioeconomic outcomes. Lastly, by conducting polygenic analyses in three independent cohorts that differed in their ascertainment and prevalence of AUD, the authors identified novel genetic associations between alcohol consumption, alcohol misuse, and health. CONCLUSIONS: This work further emphasizes the value of AUDIT for both clinical and genetic studies of AUD and the importance of using multivariate methods to study genetic associations that are more closely related to AUD.

Published
2022

5. Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood

Author

Sarah J Brislin, Jessica E Salvatore, Jacquelyn L Meyers, Chella Kamarajan, Martin H. Plawecki, Howard J. Edenberg, Sam Kuperman, Jay Tischfield, Victor Hesselbrock, Andrey Anokhin, David Chorlian, Marc A. Schuckit, John Nurnberger, Lance Bauer, Gayathri Pandey, Ashwini Kumar Pandey, John Kramer, Grace Chan, Bernice Porjesz, and Danielle Dick

Abstract

Background: Researchers have identified genetic and neural risk factors for externalizing behaviors. However, it has not yet been determined if genetic risk is conferred in part through associations with more proximal neurophysiological risk markers. Methods: Participants from the Collaborative Study on the Genetics of Alcoholism, a large, family-based study of alcohol use disorders were genotyped and polygenic risk scores for externalizing (EXT PRS) were calculated, based on a recent large-scale GWAS. Associations with target P3 amplitude from a visual oddball task (P3) and broad endorsement of externalizing behaviors (indexed via self-report of alcohol, and cannabis use, and antisocial behavior) were assessed in participants of European (N = 2,885) and African ancestry (N = 1,408). Analyses were also stratified by age (adolescents, age 12-17.9 and young adults, age 18-32).Results: The EXT PRS was significantly associated with higher levels of externalizing behaviors among adolescents and young adults of European ancestry (EA) as well as among young adults of African ancestry (AA). P3 was inversely correlated with externalizing behaviors among young adults and EA adolescents. EXT PRS was not associated with P3 amplitude and therefore, there was no evidence that P3 amplitude indirectly accounted for the association between EXT PRS and externalizing behaviors.Conclusions: The EXT PRS and P3 amplitude were each significantly associated with externalizing behaviors with the most consistent effects seen in young adults. However, these associations with externalizing behaviors appear to be independent of each other, suggesting that they may index different facets of externalizing.

Published
2022

7. Measuring retention within the adolescent brain cognitive development (ABCD)

Author

Sarah W, Feldstein Ewing, Genevieve F, Dash, Wesley K, Thompson, Chase, Reuter, Vanessa G, Diaz, Andrey, Anokhin, Linda, Chang, Linda B, Cottler, Gayathri J, Dowling, Kimberly, LeBlanc, Robert A, Zucker, Susan F, Tapert, Sandra A, Brown, and Hugh, Garavan

Subjects
Parents, Cognition, Adolescent, Brain, Educational Status, Humans
Abstract

The Adolescent Brain Cognitive Development (ABCD)

Published
2021

8. Author response for 'Pathways to post‐traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults'

Author

null Stacey Subbie‐Saenz de Viteri, null Ashwini Pandey, null Gayathri Pandey, null Chella Kamarajan, null Rebecca Smith, null Andrey Anokhin, null Lance Bauer, null Annah Bender, null Grace Chan, null Danielle Dick, null Howard Edenberg, null Sivan Kinreich, null John Kramer, null Marc Schuckit, null Yong Zang, null Vivia McCutcheon, null Kathleen Bucholz, null Bernice Porjesz, and null Jacquelyn L. Meyers

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results