Search

Your search keyword '"Andrews, William W."' showing total 606 results
Start Over Author "Andrews, William W."
606 results on '"Andrews, William W."'

1. Treatment for Mild Chronic Hypertension during Pregnancy

Author

Tita, Alan T, Szychowski, Jeff M, Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna L, Bell, Joseph, Aagaard, Kjersti, Edwards, Rodney K, Gibson, Kelly, Haas, David M, Plante, Lauren, Metz, Torri, Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George R, Hoppe, Kara K, Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle Y, Simhan, Hyagriv N, Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, August, Phyllis, Reddy, Uma M, Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary E, Skupski, Daniel, El-Sayed, Yasser Y, Ogunyemi, Dotum, Galis, Zorina S, Harper, Lorie, Ambalavanan, Namasivayam, Geller, Nancy L, Oparil, Suzanne, Cutter, Gary R, and Andrews, William W

Subjects
Paediatrics, Reproductive Medicine, Biomedical and Clinical Sciences, Lung, Clinical Trials and Supportive Activities, Hypertension, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Infant Mortality, Contraception/Reproduction, Cardiovascular, Patient Safety, Pediatric, Conditions Affecting the Embryonic and Fetal Periods, Perinatal Period - Conditions Originating in Perinatal Period, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Reproductive health and childbirth, Good Health and Well Being, Abruptio Placentae, Antihypertensive Agents, Birth Weight, Chronic Disease, Female, Fetal Growth Retardation, Humans, Hypertension, Pregnancy-Induced, Infant, Newborn, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Premature Birth, Chronic Hypertension and Pregnancy (CHAP) Trial Consortium, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe benefits and safety of the treatment of mild chronic hypertension (blood pressure,

Published
2022

2. Neonatal outcomes in term and preterm infants following adjunctive azithromycin antibiotic prophylaxis for non-elective cesarean delivery.

Author

Martin, Jane K., Longo, Sherri A., Jauk, Victoria R., Clark, Erin A.S., Saade, George R., Boggess, Kim A., Esplin, Sean, Wapner, Ronald J., Owens, Michelle Y., Blackwell, Sean C., Andrews, William W., Szychowski, Jeff M., and Tita, Alan T.

Subjects
CESAREAN section, PREMATURE infants, ANTIBIOTIC prophylaxis, NEONATAL sepsis, NEONATAL death
Abstract

Objective: It is currently unknown whether adjunctive azithromycin prophylaxis at the time of non-elective cesarean has differential effects on neonatal outcomes in the context of prematurity. The objective of this study was to compare whether neonatal outcomes differ in term and preterm infants exposed to adjunctive azithromycin prophylaxis before non-elective cesarean delivery. Study Design: A planned secondary analysis of a multi-center randomized controlled trial that enrolled women with singleton pregnancies ≥24 weeks gestation undergoing non-elective cesarean delivery (during labor or ≥4 h after membrane rupture). Women received standard antibiotic prophylaxis and were randomized to either adjunctive azithromycin (500 mg) or placebo. The primary composite outcome was neonatal death, suspected or confirmed neonatal sepsis, and serious neonatal morbidities (NEC, PVL, IVH, BPD). Secondary outcomes included NICU admission, neonatal readmission, culture positive infections and prevalence of resistant organisms. Odds ratios (OR) for the effect of azithromycin versus placebo were compared between gestational age strata (preterm [less than 37 weeks] versus term [37 weeks or greater]). Tests of interaction examined homogeneity of treatment effect with gestational age. Results: The analysis includes 2,013 infants, 226 preterm (11.2%) and 1,787 term. Mean gestational ages were 34 and 39.5 weeks, respectively. Within term and preterm strata, maternal and delivery characteristics were similar between the azithromycin and placebo groups. There was no difference in the odds of composite neonatal outcome between those exposed to azithromycin versus placebo in preterm neonates (OR 0.82, 95% CI 0.48-1.41) and in term neonates (OR 1.06, 95% CI 0.77-1.46), with no difference between gestational age strata (p = 0.42). Analysis of secondary outcomes also revealed no differences in treatment effects within or between gestational age strata. Conclusion: Exposure to adjunctive azithromycin antibiotic prophylaxis for non-elective cesarean delivery does not increase neonatal morbidity or mortality in term or preterm infants. Clinical Trial Registration: , NCT 01235546 [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Reevaluating Associations between Prenatal Care Utilization and Current Trends in Preterm Birth.

Author

Champion, Macie L., Bushman, Elisa T., Martin, Kimberly D., Battarbee, Ashley N., Robbins, Lindsay S., Andrews, William W., and Tita, Alan T.

Subjects
SOCIAL determinants of health, PREMATURE infants, LOGISTIC regression analysis, EVALUATION of medical care, RETROSPECTIVE studies, DESCRIPTIVE statistics, PRENATAL care, LONGITUDINAL method, MEDICAL appointments, CONFIDENCE intervals
Abstract

Objective Studies have suggested an association between prenatal care (PNC) and preterm birth (PTB). We evaluated trends in PTB and association of PNC and PTB. Study Design This was a retrospective cohort study of singleton, viable nonanomalous deliveries from 1991 to 2018. PNC utilization was defined by World Health Organization using number of visits: adequate (≥8), suboptimal (5–7), and inadequate (<5). Primary outcome was PTB. Tests of trend were used to assess changes in PTB over time. Baseline characteristics and outcomes were compared. Logistic regression estimated the association of PNC and PTB. We evaluated for effect modification by year of birth. Results Of 92,294 patients, 14,057 (15%) had PTB. Inadequate and suboptimal PNC were associated with higher odds of PTB compared to adequate PNC (adjusted odds ratios = [aOR 6.21], 95% confidence interval [CI]: 5.84–6.60; aOR = 3.57, 95% CI: 3.36–3.79). Inadequate PNC was associated with higher odds of PTB over time (effect modification p < 0.0001). Inadequate PNC was associated with 5.4 times higher odds of PTB in 1998, 7.0 times in 2008, and 9.1 times in 2018. Conclusion Despite an increase in adequate PNC, there was a rise in PTB associated with inadequate and suboptimal PNC. PNC utilization was a stronger risk factor in recent years with higher PTB in patients who attended more than five PNC visits. Key Points PNC utilization is associated with the risk of PTB. Despite an increase in PNC utilization, PTB rates have increased. There is an even stronger association between PNC utilization and PTB over time. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Treatment for Mild Chronic Hypertension During Pregnancy

Author

Tita, Alan T., Szychowski, Jeff M., Boggess, Kim, Dugoff, Lorraine, Sibai, Baha, Lawrence, Kirsten, Hughes, Brenna L., Bell, Joseph, Aagaard, Kjersti, Edwards, Rodney K., Gibson, Kelly, Haas, David M., Plante, Lauren, Metz, Torri, Casey, Brian, Esplin, Sean, Longo, Sherri, Hoffman, Matthew, Saade, George R., Hoppe, Kara K., Foroutan, Janelle, Tuuli, Methodius, Owens, Michelle Y., Simhan, Hyagriv N., Frey, Heather, Rosen, Todd, Palatnik, Anna, Baker, Susan, August, Phyllis, Reddy, Uma M., Kinzler, Wendy, Su, Emily, Krishna, Iris, Nguyen, Nicki, Norton, Mary E., Skupski, Daniel, El-Sayed, Yasser Y., Ogunyemi, Dotum, Galis, Zorina S., Harper, Lorie, Ambalavanan, Namasivayam, Geller, Nancy L., Oparil, Suzanne, Cutter, Gary R., and Andrews, William W.

Published
2022
Full Text
View/download PDF

11. Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis

Author

Klebanoff, Mark A., Schuit, Ewoud, Lamont, Ronald F., Larsson, Per-Göran, Odendaal, Hein J., Ugwumadu, Austin, Kiss, Herbert, Petricevic, Ljubomir, Andrews, William W., Hoffman, Matthew K., Shennan, Andrew, Seed, Paul T., Goldenberg, Robert L., Emel, Lynda M., Bhandaru, Vinay, Weiner, Steven, Larsen, Michael D., Klebanoff, Mark A., Schuit, Ewoud, Lamont, Ronald F., Larsson, Per-Göran, Odendaal, Hein J., Ugwumadu, Austin, Kiss, Herbert, Petricevic, Ljubomir, Andrews, William W., Hoffman, Matthew K., Shennan, Andrew, Seed, Paul T., Goldenberg, Robert L., Emel, Lynda M., Bhandaru, Vinay, Weiner, Steven, and Larsen, Michael D.

Abstract

BackgroundBacterial vaginosis (BV) increases preterm delivery (PTD) risk, but treatment trials showed mixed results in preventing PTD. ObjectivesDetermine, using individual participant data (IPD), whether BV treatment during pregnancy reduced PTD or prolonged time-to-delivery. Data SourcesCochrane Systematic Review (2013), MEDLINE, EMBASE, journal searches, and searches (January 2013-September 2022) ("bacterial vaginosis AND pregnancy") of (i) ; (ii) Cochrane Central Register of Controlled Trials; (iii) World Health Organization International Clinical Trials Registry Platform Portal; and (iv) Web of Science ("bacterial vaginosis"). Study Selection and Data ExtractionStudies randomising asymptomatic pregnant individuals with BV to antibiotics or control, measuring delivery gestation. Extraction was from original data files. Bias risk was assessed using the Cochrane tool. Analysis used "one-step" logistic and Cox random effect models, adjusting gestation at randomisation and PTD history; heterogeneity by I-2. Subgroup analysis tested interactions with treatment. In sensitivity analyses, studies not providing IPD were incorporated by "multiple random-donor hot-deck" imputation, using IPD studies as donors. ResultsThere were 121 references (96 studies) with 23 eligible trials (11,979 participants); 13 studies (6915 participants) provided IPD; 12 (6115) were incorporated. Results from 9 (4887 participants) not providing IPD were imputed. Odds ratios for PTD for metronidazole and clindamycin versus placebo were 1.00 (95% CI 0.84, 1.17), I-2 = 62%, and 0.59 (95% CI 0.42, 0.82), I-2 = 0 before; and 0.95 (95% CI 0.81, 1.11), I-2 = 59%, and 0.90 (95% CI: 0.72, 1.12), I-2 = 0, after imputation. Time-to-delivery did not differ from null with either treatment. Including imputed IPD, there was no evidence that either drug was more effective when administered earlier, or among those with a PTD history. ConclusionsClindamycin, but not metronidazole, was beneficial in studies provid

Published
2023
Full Text
View/download PDF

12. Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis

Author

Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Klebanoff, Mark A., Schuit, Ewoud, Lamont, Ronald F., Larsson, Per Göran, Odendaal, Hein J., Ugwumadu, Austin, Kiss, Herbert, Petricevic, Ljubomir, Andrews, William W., Hoffman, Matthew K., Shennan, Andrew, Seed, Paul T., Goldenberg, Robert L., Emel, Lynda M., Bhandaru, Vinay, Weiner, Steven, Larsen, Michael D., Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Klebanoff, Mark A., Schuit, Ewoud, Lamont, Ronald F., Larsson, Per Göran, Odendaal, Hein J., Ugwumadu, Austin, Kiss, Herbert, Petricevic, Ljubomir, Andrews, William W., Hoffman, Matthew K., Shennan, Andrew, Seed, Paul T., Goldenberg, Robert L., Emel, Lynda M., Bhandaru, Vinay, Weiner, Steven, and Larsen, Michael D.

Published
2023

13. Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta‐analysis

Author

Klebanoff, Mark A., primary, Schuit, Ewoud, additional, Lamont, Ronald F., additional, Larsson, Per‐Göran, additional, Odendaal, Hein J., additional, Ugwumadu, Austin, additional, Kiss, Herbert, additional, Petricevic, Ljubomir, additional, Andrews, William W., additional, Hoffman, Matthew K., additional, Shennan, Andrew, additional, Seed, Paul T., additional, Goldenberg, Robert L., additional, Emel, Lynda M., additional, Bhandaru, Vinay, additional, Weiner, Steven, additional, and Larsen, Michael D., additional

Published
2023
Full Text
View/download PDF

48. Midpregnancy genitourinary tract infection with Chlamydia trachomatis: Association with subsequent preterm delivery in women with bacterial vaginosis and Trichomonas vaginalis

Author

Andrews, William W., Klebanoff, Mark A., Thom, Elizabeth A., Hauth, John C., Carey, J. Christopher, Meis, Paul J., Caritis, Steve N., Leveno, Kenneth J., Wapner, Ronald J., Varner, Michael W., Iams, J.D., Moawad, Atef, Miodovnik, Menachem, Sibai, Baha, Dombrowski, Mitchell, Langer, Oded, and O'Sullivan, Mary J.

Published
2006
Full Text
View/download PDF

50. Choriodecidual infection and preterm birth

Author

Goldenberg, Robert L., Andrews, William W., and Hauth, John C.

Subjects
Infants (Premature) -- Patient outcomes, Mortality -- Risk factors, Bacterial infections -- Health aspects, Food/cooking/nutrition
Abstract

Of all U.S. births, 11% occur preterm. These infants are responsible for the majority of perinatal mortality and morbidity. Infants at highest risk are those born weighing

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results