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2. APOGEE DR14/DR15 Abundances in the Inner Milky Way

Author

Zasowski, G., Schultheis, M., Hasselquist, S., Cunha, K., Sobeck, J., Johnson, J. A., Rojas-Arriagada, A., Majewski, S. R., Andrews, B. H., Jonsson, H., Beers, T. C., Chojnowski, S. D., Frinchaboy, P. M., Holtzman, J. A., Minniti, D., Nidever, D. L., and Nitschelm, C.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present an overview of the distributions of 11 elemental abundances in the Milky Way's inner regions, as traced by APOGEE stars released as part of SDSS Data Release 14/15 (DR14/DR15), including O, Mg, Si, Ca, Cr, Mn, Co, Ni, Na, Al, and K. This sample spans ~4000 stars with R_GC<4 kpc, enabling the most comprehensive study to date of these abundances and their variations within the innermost few kiloparsecs of the Milky Way. We describe the observed abundance patterns ([X/Fe]-[Fe/H]), compare to previous literature results and to patterns in stars at the solar Galactic radius, and discuss possible trends with DR14/DR15 effective temperatures. We find that the position of the [Mg/Fe]-[Fe/H] "knee" is nearly constant with R_GC, indicating a well-mixed star-forming medium or high levels of radial migration in the early inner Galaxy. We quantify the linear correlation between pairs of elements in different subsamples of stars and find that these relationships vary; some abundance correlations are very similar between the alpha-rich and alpha-poor stars, but others differ significantly, suggesting variations in the metallicity dependencies of certain supernova yields. These empirical trends will form the basis for more detailed future explorations and for the refinement of model comparison metrics. That the inner Milky Way abundances appear dominated by a single chemical evolutionary track and that they extend to such high metallicities underscore the unique importance of this part of the Galaxy for constraining the ingredients of chemical evolution modeling and for improving our understanding of the evolution of the Galaxy as a whole., Comment: Submitted to AAS Journals; revised after referee report

Published
2018
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3. SDSS-IV MaNGA: Spatially resolved star-formation histories and the connection to galaxy physical properties

Author

Rowlands, K., Heckman, T., Wild, V., Zakamska, N. L., Rodriguez-Gomez, V., Barrera-Ballesteros, J., Lotz, J., Thilker, D., Andrews, B. H., Brinkmann, J., Boquien, M., Brownstein, J. R., Hwang, H-C., and Smethurst, R.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

A key task of observational extragalactic astronomy is to determine where -- within galaxies of diverse masses and morphologies -- stellar mass growth occurs, how it depends on galaxy properties and what processes regulate star formation. Using spectroscopic indices derived from the stellar continuum at $\sim 4000$\AA, we determine the spatially resolved star-formation histories of 980000 spaxels in 2404 galaxies in the SDSS-IV MaNGA IFU survey. We examine the spatial distribution of star-forming, quiescent, green valley, starburst and post-starburst spaxels as a function of stellar mass and morphology to see where and in what types of galaxy star formation is occurring. The spatial distribution of star-formation is dependent primarily on stellar mass, with a noticeable change in the distribution at \mstar$>10^{10}$\msun. Galaxies above this mass have an increasing fraction of regions that are forming stars with increasing radius, whereas lower mass galaxies have a constant fraction of star forming regions with radius. Our findings support a picture of inside-out growth and quenching at high masses. We find that morphology (measured via concentration) correlates with the fraction of star-forming spaxels, but not with their radial distribution. We find (post-)starburst regions are more common outside of the galaxy centre, are preferentially found in asymmetric galaxies, and have lower gas-phase metallicity than other regions, consistent with interactions triggering starbursts and driving low metallicity gas into regions at $<1.5R_e$., Comment: Accepted for publication in MNRAS. 16 pages, 14 figures

Published
2018
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4. Direct evaluation of the force constant matrix in quantum Monte Carlo

Author

Liu, YYF, Andrews, B, and Conduit, GJ

Subjects
Physical Sciences, Chemical Sciences, Physical Chemistry, Theoretical and Computational Chemistry, Engineering, Chemical Physics, Chemical sciences, Physical sciences
Abstract

We develop a formalism to directly evaluate the matrix of force constants within a Quantum Monte Carlo calculation. We utilize the matrix of force constants to accurately relax the positions of atoms in molecules and determine their vibrational modes, using a combination of variational and diffusion Monte Carlo. The computed bond lengths differ by less than 0.007 Å from the experimental results for all four tested molecules. For hydrogen and hydrogen chloride, we obtain fundamental vibrational frequencies within 0.1% of experimental results and ∼10 times more accurate than leading computational methods. For carbon dioxide and methane, the vibrational frequency obtained is on average within 1.1% of the experimental result, which is at least 3 times closer than results using restricted Hartree-Fock and density functional theory with a Perdew-Burke-Ernzerhof functional and comparable or better than density functional theory with a semi-empirical functional.

Published
2019

6. Probing the kinematic morphology-density relation of early-type galaxies with MaNGA

Author

Greene, J. E., Leauthaud, A., Emsellem, E., Goddard, D., Ge, J., Andrews, B. H., Brinkman, J., Brownstein, J. R., Greco, J. P., Law, D., Lin, Y. -T., Masters, K. L., Merrifield, M., More, S., Okabe, N., Schneider, D. P., Thomas, D., Wake, D. A., Yan, R., and Drory, N.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The "kinematic" morphology-density relation for early-type galaxies posits that those galaxies with low angular momentum are preferentially found in the highest-density regions of the universe. We use a large sample of galaxy groups with halo masses 10^12.5 < M_halo < 10^14.5 M_sun/h observed with the Mapping Nearby Galaxies at APO (MaNGA) survey to examine whether there is a correlation between local environment and rotational support that is independent of stellar mass. We find no compelling evidence for a relationship between the angular momentum content of early-type galaxies and either local overdensity or radial position within the group at fixed stellar mass., Comment: 5 pages, 2 figures, accepted for publication in ApJL

Published
2017
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7. Target Selection for the SDSS-IV APOGEE-2 Survey

Author

Zasowski, G., Cohen, R. E., Chojnowski, S. D., Santana, F., Oelkers, R. J., Andrews, B., Beaton, R. L., Bender, C., Bird, J. C., Bovy, J., Carlberg, J. K., Covey, K., Cunha, K., Dell'Agli, F., Fleming, S. W., Frinchaboy, P. M., Garcia-Hernandez, D. A., Harding, P., Holtzman, J., Johnson, J. A., Kollmeier, J. A., Majewski, S. R., Meszaros, Sz., Munn, J., Munoz, R. R., Ness, M. K., Nidever, D. L., Poleski, R., Zuniga, C. Roman, Shetrone, M., Simon, J. D., Smith, V. V., Sobeck, J. S., Stringfellow, G. S., Szigetiaros, L., Tayar, J., and Troup, N.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics
Abstract

APOGEE-2 is a high-resolution, near-infrared spectroscopic survey observing roughly 300,000 stars across the entire sky. It is the successor to APOGEE and is part of the Sloan Digital Sky Survey IV (SDSS-IV). APOGEE-2 is expanding upon APOGEE's goals of addressing critical questions of stellar astrophysics, stellar populations, and Galactic chemodynamical evolution using (1) an enhanced set of target types and (2) a second spectrograph at Las Campanas Observatory in Chile. APOGEE-2 is targeting red giant branch (RGB) and red clump (RC) stars, RR Lyrae, low-mass dwarf stars, young stellar objects, and numerous other Milky Way and Local Group sources across the entire sky from both hemispheres. In this paper, we describe the APOGEE-2 observational design, target selection catalogs and algorithms, and the targeting-related documentation included in the SDSS data releases., Comment: 19 pages, 6 figures. Accepted to AJ

Published
2017
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8. SDSS IV MaNGA: Deep observations of extra-planar, diffuse ionized gas around late-type galaxies from stacked IFU spectra

Author

Jones, A., Kauffmann, G., D'Souza, R., Bizyaev, D., Law, D., Haffner, L., Bahé, Y., Andrews, B., Bershady, M., Brownstein, J., Bundy, K., Cherinka, B., Diamond-Stanic, A., Drory, N., Riffel, R. A., Thomas, S. F. Sánchez D., Wake, D., Yan, R., and Zhang, K.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We have conducted a study of extra-planar diffuse ionized gas using the first year data from the MaNGA IFU survey. We have stacked spectra from 49 edge-on, late-type galaxies as a function of distance from the midplane of the galaxy. With this technique we can detect the bright emission lines Halpha, Hbeta, [OII]3726, 3729, [OIII]5007, [NII]6549, 6584, and [SII]6717, 6731 out to about 4 kpc above the midplane. With 16 galaxies we can extend this analysis out to about 9 kpc, i.e. a distance of ~2R_e, vertically from the midplane. In the halo, the surface brightnesses of the [OII] and Halpha emission lines are comparable, unlike in the disk where Halpha dominates. When we split the sample by specific star formation rate, concentration index, and stellar mass, each subsample's emission line surface brightness profiles and ratios differ, indicating that extra-planar gas properties can vary. The emission line surface brightnesses of the gas around high specific star formation rate galaxies are higher at all distances, and the line ratios are closer to ratios characteristic of HII regions compared with low specific star formation rate galaxies. The less concentrated and lower stellar mass samples exhibit line ratios that are more like HII regions at larger distances than their more concentrated and higher stellar mass counterparts. The largest difference between different subsamples occurs when the galaxies are split by stellar mass. We additionally infer that gas far from the midplane in more massive galaxies has the highest temperatures and steepest radial temperature gradients based on their [NII]/Halpha and [OII]/Halpha ratios between the disk and the halo., Comment: 19 pages, 14 figures, 2 appendices. Accepted in A&A (see https://drive.google.com/open?id=0B_MhxrO1dvVNUUUtb0FXdllqb0E for full version)

Published
2016
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10. Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

Author

Blanton, MR, Bershady, MA, Abolfathi, B, Albareti, FD, Prieto, CA, Almeida, A, Alonso-García, J, Anders, F, Anderson, SF, Andrews, B, Aquino-Ortíz, E, Aragón-Salamanca, A, Argudo-Fernández, M, Armengaud, E, Aubourg, E, Avila-Reese, V, Badenes, C, Bailey, S, Barger, KA, Barrera-Ballesteros, J, Bartosz, C, Bates, D, Baumgarten, F, Bautista, J, Beaton, R, Beers, TC, Belfiore, F, Bender, CF, Berlind, AA, Bernardi, M, Beutler, F, Bird, JC, Bizyaev, D, Blanc, GA, Blomqvist, M, Bolton, AS, Boquien, M, Borissova, J, Bosch, RVD, Bovy, J, Brandt, WN, Brinkmann, J, Brownstein, JR, Bundy, K, Burgasser, AJ, Burtin, E, Busca, NG, Cappellari, M, Carigi, MLD, Carlberg, JK, Rosell, AC, Carrera, R, Chanover, NJ, Cherinka, B, Cheung, E, Chew, YGM, Chiappini, C, Choi, PD, Chojnowski, D, Chuang, CH, Chung, H, Cirolini, RF, Clerc, N, Cohen, RE, Comparat, J, Costa, LD, Cousinou, MC, Covey, K, Crane, JD, Croft, RAC, Cruz-Gonzalez, I, Cuadra, DG, Cunha, K, Damke, GJ, Darling, J, Davies, R, Dawson, K, Macorra, ADL, Dell'Agli, F, Lee, ND, Delubac, T, Mille, FD, Diamond-Stanic, A, Cano-Díaz, M, Donor, J, Downes, JJ, Drory, N, Bourboux, HDMD, Duckworth, CJ, Dwelly, T, Dyer, J, Ebelke, G, Eigenbrot, AD, Eisenstein, DJ, Emsellem, E, Eracleous, M, Escoffier, S, Evans, ML, Fan, X, and Fernández-Alvar, E

Subjects
cosmology: observations, galaxies: general, Galaxy: general, instrumentation: spectrographs, stars: general, surveys, astro-ph.GA, Astronomy & Astrophysics, Astronomical and Space Sciences
Abstract

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z ∼ 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z ~ 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.

Published
2017

11. SDSS-IV MaNGA IFS GALAXY SURVEY - SURVEY DESIGN, EXECUTION, and INITIAL DATA QUALITY

Author

Yan, R, Bundy, K, Law, DR, Bershady, MA, Andrews, B, Cherinka, B, Diamond-Stanic, AM, Drory, N, MacDonald, N, Sánchez-Gallego, JR, Thomas, D, Wake, DA, Weijmans, AM, Westfall, KB, Zhang, K, Aragón-Salamanca, A, Belfiore, F, Bizyaev, D, Blanc, GA, Blanton, MR, Brownstein, J, Cappellari, M, D'Souza, R, Emsellem, E, Fu, H, Gaulme, P, Graham, MT, Goddard, D, Gunn, JE, Harding, P, Jones, A, Kinemuchi, K, Li, C, Li, H, Maiolino, R, Mao, S, Maraston, C, Masters, K, Merrifield, MR, Oravetz, D, Pan, K, Parejko, JK, Sanchez, SF, Schlegel, D, Simmons, A, Thanjavur, K, Tinker, J, Tremonti, C, Van Den Bosch, R, and Zheng, Z

Subjects
galaxies: evolution, galaxies: general, surveys, techniques: imaging spectroscopy, astro-ph.GA, Astronomy & Astrophysics, Astronomical and Space Sciences
Abstract

The MaNGA Survey (Mapping Nearby Galaxies at Apache Point Observatory) is one of three core programs in the Sloan Digital Sky Survey IV. It is obtaining integral field spectroscopy for 10,000 nearby galaxies at a spectral resolution of R ∼ 2000 from 3622 to 10354 Å. The design of the survey is driven by a set of science requirements on the precision of estimates of the following properties: star formation rate surface density, gas metallicity, stellar population age, metallicity, and abundance ratio, and their gradients; stellar and gas kinematics; and enclosed gravitational mass as a function of radius. We describe how these science requirements set the depth of the observations and dictate sample selection. The majority of targeted galaxies are selected to ensure uniform spatial coverage in units of effective radius (R e) while maximizing spatial resolution. About two-thirds of the sample is covered out to 1.5R e (Primary sample), and one-third of the sample is covered to 2.5R e (Secondary sample). We describe the survey execution with details that would be useful in the design of similar future surveys. We also present statistics on the achieved data quality, specifically the point-spread function, sampling uniformity, spectral resolution, sky subtraction, and flux calibration. For our Primary sample, the median r-band signal-to-noise ratio is ∼70 per 1.4 Å pixel for spectra stacked between 1R e and 1.5R e. Measurements of various galaxy properties from the first-year data show that we are meeting or exceeding the defined requirements for the majority of our science goals.

Published
2016

12. QUANTITATIVE ANALYSIS OF MIRABEGRON ER TABLETS: A COMPREHENSIVE RP-HPLC METHOD AND VALIDATION FOR THE IMPURITY DETERMINATION.

Author

Kumar, G. T. Jyothesh, Andrews, B. S. A., Abbaraju, V. D. N. Kumar, V., Sreeram, Reddy, P. Sunil, and Kola, Avinash Rai

Subjects
*GRADIENT elution (Chromatography), *HIGH performance liquid chromatography, *QUALITY control, *ACETONITRILE, *DETECTION limit
Abstract

This research aimed to design as well as evaluate reverse-phase high-performance liquid chromatography (RPHPLC) process to precise quantification for potential impurities in Mirabegron (MIRA) ER Tablets. The developed method utilized an Inertsil C8 - 3, 150 x 4.6 mm, 3µm column with a gradient elution program utilizing Buffer and Acetonitrile as mobile phases. The chromatographic separation achieved on a C8 stationary phase demonstrated robustness and reproducibility, with detection at a wavelength of 240 nm and a constant column temperature of 40°C. The research study was focused on MIRA and four impurities (MIR-1, Deshydroxy, Diamide-1, and Diamide-2). The method exhibited specificity, precision, linearity, accuracy, robustness, ruggedness, and stability indicating characteristics. Correlation coefficients exceeding 0.997 for MIRA and its foreign substances showcased the accuracy and sensitivity of the method. Low detection and quantization limits (ranging from 0.06ppm to 0.20ppm) highlighted its high sensitivity. Accuracy is finalized by rates of recovery as 96.1% to 100.3% for all foreign substances. The stability-indicating is validated by forced degradation studies, meeting peak purity circumstances also achieving mass balance. Robustness studies further established the method's reliability, demonstrating resilience to minor chromatographic variations. This proposed RP-HPLC method accommodates a dependable, reproducible, highly accurate, and more sensitive means to quantifying MIRA-related substances in MIRA ER Tablets, making it a valuable tool for pharmaceutical quality control. [ABSTRACT FROM AUTHOR]

Published
2024
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14. 105P Targeting the tRNA methyltransferase METTL1 with small molecule inhibitors in cancer

Author

Sapetschnig, A., primary, Thomas, B., additional, Yankova, E., additional, Fischl, H., additional, Azevedo, A., additional, Bucknell, S., additional, Fosbeary, R., additional, Sawyer, S., additional, Evans, S., additional, Livi, C., additional, Andrews, B., additional, Rogan, J., additional, Webster, N., additional, Fyfe, M., additional, Tzelepis, K., additional, and Rausch, O., additional

Published
2024
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16. Ash production and dispersal from sustained low-intensity Mono-Inyo eruptions

Author

Black, BA, Manga, M, and Andrews, B

Subjects
Mono-Inyo eruptions, Rhyolitic volcanism, Ash venting, X-ray computed tomography, Ash3d, Geochemistry & Geophysics, Geology
Abstract

Recent rhyolitic volcanism has demonstrated that prolonged low-intensity ash venting may accompany effusive dome formation. We examine the possibility and some consequences of episodes of extended, weak ash venting at the rhyolitic Mono-Inyo chain in Eastern California. We describe ash-filled cracks within one of the youngest domes, Panum Crater, which provide a textural record of ash venting during dome effusion. We use synchrotron-based X-ray computed tomography to characterize the particles in these tuffisites. Particle sizes in well-sorted tuffisite layers agree well with grain size distributions observed during weak ash venting at Soufrière Hills Volcano, Montserrat, and yield approximate upper and lower bounds on gas velocity and mass flux during the formation of those layers. We simulate ash dispersal with Ash3d to assess the consequences of long-lived Mono-Inyo ash venting for ash deposition and the accompanying volcanic hazards. Our results highlight the sensitivity of large-scale outcomes of volcanic eruptions to small-scale processes.

Published
2016

17. Target Selection for the Apache Point Observatory Galactic Evolution Experiment (APOGEE)

Author

Zasowski, G., Johnson, Jennifer A., Frinchaboy, P. M., Majewski, S. R., Nidever, D. L., Pinto, H. J. Rocha, Girardi, L., Andrews, B., Chojnowski, S. D., Cudworth, K. M., Jackson, K., Munn, J., Skrutskie, M. F., Beaton, R. L., Blake, C. H., Covey, K., Deshpande, R., Epstein, C., Fabbian, D., Fleming, S. W., Hernandez, A. Garcia, Herrero, A., Mahadevan, S., Meszaros, Sz., Schultheis, M., Sellgren, K., Terrien, R., van Saders, J., Prieto, C. Allende, Bizyaev, D., Burton, A., Cunha, K., da Costa, L. N., Hasselquist, S., Hearty, F., Holtzman, J., Perez, A. E. Garcia, Maia, M. A. G., O'Connell, R. W., O'Donnell, C., Pinsonneault, M., Santiago, B. X., Schiavon, R. P., Shetrone, M., Smith, V., and Wilson, J. C.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The Apache Point Observatory Galactic Evolution Experiment (APOGEE) is a high-resolution infrared spectroscopic survey spanning all Galactic environments (i.e., bulge, disk, and halo), with the principal goal of constraining dynamical and chemical evolution models of the Milky Way. APOGEE takes advantage of the reduced effects of extinction at infrared wavelengths to observe the inner Galaxy and bulge at an unprecedented level of detail. The survey's broad spatial and wavelength coverage enables users of APOGEE data to address numerous Galactic structure and stellar populations issues. In this paper we describe the APOGEE targeting scheme and document its various target classes to provide the necessary background and reference information to analyze samples of APOGEE data with awareness of the imposed selection criteria and resulting sample properties. APOGEE's primary sample consists of ~100,000 red giant stars, selected to minimize observational biases in age and metallicity. We present the methodology and considerations that drive the selection of this sample and evaluate the accuracy, efficiency, and caveats of the selection and sampling algorithms. We also describe additional target classes that contribute to the APOGEE sample, including numerous ancillary science programs, and we outline the targeting data that will be included in the public data releases., Comment: Accepted to AJ. 31 pages, 11 figures

Published
2013
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19. KINETICS OF PENTAAMMINECOBALT(III) COMPLEXES OF α-AMINO ACIDS BY CARO'S ACID IN MICELLAR MEDIUM.

Author

Rajkumar, P., Buvaneswari, N., Suresh, M., Afroze, N. Nadeem, Andrews, B., and Elumalai, S.

Subjects
CHEMICAL synthesis, CARBONYL compounds, ACIDS, ACRYLONITRILE
Abstract

The final products of the process are carbonyl compounds, which are produced by the oxidation of pentaamminecobalt(III) complexes of bound and unbound a-amino acids by Caro's acid in a micellar medium. At 32°C, it has been examined. On [a-amino acids] and [Caro's acid], the rate of the reaction exhibits first-order kinetics in both cases. The reaction rate is accelerated by the addition of micelles. After the reaction, a UV-visible spectrophotometer monitors the decline in Co(III)'s absorbance at 504 nm. The reaction's stoichiometry is 0.5 moles of Co(III) a-amino acid complexes using 1.0 mole of Caro's acid, as opposed to 1.0 moles of unbound a-amino acids consuming 1.0 mole of Caro's acid. Acrylonitrile cannot be made to polymerize by reaction. FTIR Spectra have been used to support every one of the freshly synthesized compounds' structural details. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Towards the Future: Teachers' Vision of Professional Development in the Arts

Author

Andrews, B. W.

Abstract

Teachers enrolled in a professional development program involving artists on site at cultural institutions participated in a study in which they expressed their views on upgrading in the arts. Findings indicate that they were influenced in their own schooling by passionate teachers who conveyed the importance of the arts. Their progress was impeded by a self-perception of their own limited artistic ability. Community experiences, such as private lessons and amateur productions, played a more significant role in their development. The ideal scenario for their personal and professional development in the arts is an environment where discipline-based and integrative curricular activities are offered, and both the creative process and the creative product are valued. Lack of personal expertise, limited professional development opportunities, and inadequate funding are obstacles that can be overcome by teacher commitment to upgrading in the arts, a range of arts courses offered by education faculties, and involvement by arts stakeholders in program design and delivery, respectively.

Published
2016
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23. Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Author

Spiers, H, Kouli, O, Ahmed, W, Varley, R, Ahari, D, Argus, L, Mclean, K, Kamarajah, S, Coe, P, Griffiths, E, Chan, A, Macutkiewicz, C, Jamdar, S, Wilson, M, Fullwood, C, Toogood, G, Gilchrist, A, Goldsworthy, M, Rashid, M, Pockney, P, Varela, J, Brindl, N, Ramirez, J, Marafante, C, Iwao, Y, Ghzawi, A, Elhadi, M, Gacaferi, H, Varghese, C, Adeyeye, A, Alser, O, Teh, C, Prieto, M, Hasan, A, Al-Naggar, H, Salgado, R, Veracierto, F, Lancelotti, T, Solinas, D, Oddi, R, Garcia, F, Mazza Diez, E, Andrade Ramirez, M, Bracco, R, Fernandez, D, Maraschio, M, Obeide, L, Giordano, E, Alcaraz, A, Marani, M, Aguirre, N, Luna, F, Francesconi, M, Chiham, F, Ramos Cossio, R, Alvarez, F, Pantoja Pachajoa, D, Mandojana, F, Merlo, I, Gonzalez, M, Cervelo, G, Puma, R, Vardaro, G, Davis, A, Jurat, D, Guenoff, C, Raubenheimer, K, Goddard, K, Brown, K, Wegrecki, K, Cheung, H, Yang, M, Siddiqui, J, Ahn, J, Huynh, R, Lam, Y, Afzal, M, Ong, B, Chua, M, Ly, K, Thomson, J, Watson, D, Dawson, A, Drane, A, Van Ruyven, S, Lun, E, Ferguson, M, Jeong, J, De Silva, C, Wills, V, Gundara, J, Mccourt, E, Bong, C, Tabone, R, Wong, W, Gray, A, Koh, D, Pollock, M, Singhal, S, Smith, R, Dudi-Venkata, N, Kanhere, H, Stranz, C, Seow, W, Mansour, L, Wormald, J, Loveday, B, Thomson, B, O'Donnell, T, Milenkovski, N, Herath, M, Trochsler, M, Farfus, A, Maddern, G, Bunjo, Z, Kuan, L, Atanasov, G, Samadov, E, Namazov, I, Asgarov, M, Ibrahimli, A, Srinivasan, M, Saeed, M, Aljawder, H, Juma, I, Coimbra, F, Marques, N, Casteleins, W, Petruzziello, A, Jabur, G, Rodriguez, J, Buso, P, Mackenzie, S, Hsiao, M, Sljivic, I, Tecson, A, Karanicolas, P, Roke, R, Moon, J, Butler, E, Riquelme, F, Yanez, M, Catan, F, Uribe, M, Carriel, F, Oppliger, F, Paredes, A, Daroch, D, Aguayo, J, Perez Rivera, C, Acosta Buitrago, L, Kadamani Abiyomaa, A, Mosquera Paz, M, Cabrera, P, Corso, J, Ozcay, N, Ozant, A, Arslan, K, Besim, H, Almezghwi, H, Azzam, A, Bessa, S, El-Sayes, I, Badawy, A, Wael, M, El-Gendi, A, Azab, M, Fayed, M, El Kassas, M, Gamal, M, Tawheed, A, Al Shafie, A, Emile, S, Elfallal, A, Elfeki, H, Shalaby, M, Sakr, A, Elbahnasawy, M, Shama, M, Abdel-Elsalam, W, Abd-Elsalam, S, Escobar Dominguez, J, Medrano, F, Gaitan, S, Escalon Gonzalez, O, Alfaro Varela, J, Cea, M, Interiano, M, Cabrera, B, Lakkis, Z, Georges, P, Antonot, C, Magnin, J, Kamphues, C, Lauscher, J, Schineis, C, Loch, F, Lee, L, Beyer, K, Bouchagier, K, Galanis, I, Bartziotas, D, Lostoridis, E, Tourountzi, P, Nagorni, E, Charalabopoulos, A, Baili, E, Kyros, E, Vagios, I, Skotsimara, A, Liakakos, T, Alexandrou, A, Papalampros, A, Papadopolous, V, Tooulias, A, Kentarchos, I, Christou, C, Tsoulfas, G, Tale-Rosales, L, Lopez Muralles, I, Melendez, H, Bran, G, Monroy Mahecha, F, Contreras, J, Porras, D, Paiz, E, Soto, E, Ixcayau Hernandez, J, Gupta, A, Rajput, D, Kumar, N, Mani, R, Kant, R, Sonkar, A, Anand, A, Agrawal, M, Gaurav, K, Tripathi, M, Sikora, S, Bharathy, K, Kumar Rangapa, M, Khuller, D, Bhojwwani, R, Ayyar, S, Jain, N, Mehraj, A, Hussain, 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M, De Andres-Asenjo, B, Beltran-Heredia, J, Gimenez Maurel, T, Utrilla Fornals, A, Martin Anoro, L, Cortese, S, Perez Diaz, M, Ballon, M, Morote, M, Cebolla Rojas, L, Oliver Guillen, J, Lopez De Fernandez, A, Del Campo Lavilla, M, Mora-Guzman, I, Escartin, A, Pinillos, A, Vela Polanco, F, Jara Quezada, J, Muriel Alvarez, P, Tur-Martinez, J, Camps, J, Herrero, E, Garcia-Domingo, M, Cugat Andorra, E, Crespi Mir, A, Claramonte Bellmunt, O, Vicens Arbona, J, Fernandez Burgos, I, Sarriugarte Lasarte, A, Marin, H, Tellaeche De La Iglesia, M, Ocerin Alganza, O, Salinas Gomez, J, Ramos-Martin, P, Urbieta, A, Nasimi Sabbagh, R, Castell Gomez, J, Serrablo, A, Paterna -Lopez, S, GutiCrossed D SignCopyrightrrez-Diez, M, Abadia-Forcen, M, Serradilla-Martin, M, Duran Munoz-Cruzado, V, Pareja Ciuro, F, Perea Del Pozo, E, Aparicio Sanchez, D, Dios-Barbeito, S, Marenco De La Cuadra, B, Retamar Gentil, M, Reguera-Rosal, J, Infantes Ormad, M, Lopez-Ruiz, J, Landaluce-Olavarria, A, Zevallos-Quiroz, J, Barrutia Leonardo, J, Emaldi, A, Begona, E, Balciscueta Coltell, I, Sebastian, M, Martinez Ramos, S, Martinez Alcaide, S, Lorenzo Perez, J, Martinez Insfran, L, Lopez-Morales, P, Gimenez Frances, C, Rahy-Martin, A, Pelloni, M, Ortiz-Lopez, D, Benet-Munoz, O, Pinero-Gonzalez, L, Alconchel, F, Nicolas-Lopez, T, Rodrigues, K, Cascales Campos, P, Gomez-Bosch, F, Ramirez Romero, P, Ibrahim, M, Hamid, H, Idres, R, Idris, M, Mohammed, O, Ayran, S, Sinan, A, Ozben, V, Aytac, E, Aliyeva, Z, Mutlu, A, Bilgin, I, Karahasanoglu, T, Hamzaoglu, I, Bozkirli, B, Uprak, T, Kotan, T, Coskun, M, Kara, Y, Somuncu, E, Kocatas, A, Bozkurt, M, Demirli Atici, S, Kaya, T, Sert, I, Emiroglu, M, Jaffar, M, Younis, M, Aziz, T, Ikram, F, Sandal, M, Al Madhloum Al Suwaidi, F, Alshaikh, M, Saber, A, Khammas, A, Nessa, A, Jardine, R, Nicol, L, Clark, C, Mcgee, A, Alkari, B, Feretis, M, Antakia, R, Georgiades, F, Moneim, J, O'Neill, R, Balakrishnan, A, Lunevicius, R, Sud, A, Moutsos, I, Gomez, D, Shahid, S, Majeed, T, Ibrahim, W, Kadum, K, Melia, R, Magee, C, Chicken, D, Kumar, S, Alshibshoubi, M, Van Laarhoven, S, Dewi, F, Williams, J, Byrne, B, Wilkerson, P, Tang, C, Farhangmehr, N, Jonas, A, Charavanamuttu, V, Almeida, K, Efthimiou, E, Boardley, J, White, A, Butt, M, Menzies, D, Gundkalli, Z, Hassanzadeh-Baboli, D, Jones, O, Mistry, P, Saha, S, Gerrard, A, Evans, J, Rajeev, S, Ali, W, Ross, E, Gilliam, A, Hitchins, C, Emslie, K, Spellar, K, Sked, H, Briggs, C, Brown, L, A Hemadasa, N, Apollos, J, Belgaumkar, A, Tawfik, A, Brewin, L, Oyewole, B, Wadhawan, H, Massie, E, Rutherford, D, Mcgivern, K, Mcelroy, L, De'Ath, H, Tobbal, M, Nagendram, S, Patel, P, Handa, S, Houghton, G, Sundaralingam, S, Parker, J, Morgan, R, Gala, T, Ibrahim, S, Harby, R, Abdelkarim, M, Holroyd, D, Thomas, R, Mclennan, E, Boardley, R, Jamieson, N, Ebied, H, Gossage, J, Davies, A, Wheatstone, S, Jawad, Z, Jiao, L, Rajagopal, P, Sodergren, M, Lami, M, Wiberg, A, Bond-Smith, G, Gemmill, E, Lenzi, E, Sapre, D, Herrod, P, 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N, Pissanou, T, Mestre-Costa, J, Hidalgo Salinas, C, Pollok, J, Al-Ardah, M, Watson-Jones, E, Rontree-Carey, T, Boyce, T, Hawkin, P, Elmaradny, A, Ross, K, Adu-Peprah, E, Pinto, K, Dunne, D, Mccready, R, Nita, G, Szatmary, P, Tay, V, Rajput, K, Rajendran, I, Chaudhury, M, Zambas, G, Swaminathan, C, Atif, Q, Barrow, T, Williams, O, Malik, A, Conroy, S, Lindley, S, Gilmore, K, Boden, E, Richards, S, Hraishawi, I, Polak, P, Mclaughlin, D, Deeny, D, Shuttleworth, R, Harris, A, Peilober-Richardson, A, Morris, G, Sara, X, Almourad, H, Ang, Y, Smyth, R, Ding, D, Foster, J, Bond, A, Kumar, Y, Ahmad, A, Radoi, D, Alkaili-Alyamani, A, Balakrishnan, S, Satchidanand, R, Danwaththa Liyanage, A, Blake, I, Ransome, M, Weerasinghe, C, Kenington, C, Mayo, K, Mohammed, M, Cockbain, A, Peckham-Cooper, A, Mccauley, G, Gordon, C, Smith, A, Hawkins, W, Chakravartty, S, Baillie, C, Kenny, R, Kumar, A, Koimtzis, G, Bellamy, E, Menon, A, Kanakala, A, Nevins, E, Madhavan, A, Thulasiraman, S, France, K, 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V. M., Kouli O., Ahmed W. U., Varley R., Ahari D., Argus L., McLean K. A., Kamarajah S. K., Coe P., Griffiths E. A., Chan A. K. C., Macutkiewicz C., Jamdar S., Wilson M., Fullwood C., Toogood G., McLean K., Ahmed W., Gilchrist A., Goldsworthy M., Rashid M., Pockney P., Varela J., Brindl N., Ramirez J., Marafante C., Iwao Y., Ghzawi A., Elhadi M., Gacaferi H., Varghese C., Adeyeye A., Alser O., Teh C., Prieto M., Hasan A., Al-Naggar H., Salgado R., Veracierto F., Lancelotti T., Solinas D., Oddi R., Garcia F. W., Mazza Diez E., Andrade Ramirez M. R., Bracco R., Fernandez D., Maraschio M. A., Obeide L., Giordano E., Alcaraz A., Marani M. A., Aguirre N., Luna F., Francesconi M., Chiham F., Ramos Cossio R., Alvarez F. A., Pantoja Pachajoa D. A., Mandojana F., Merlo I. G., Gonzalez M. H., Cervelo G., Puma R., Vardaro G. F., Davis A., Jurat D., Guenoff C., Raubenheimer K., Goddard K., Brown K., Wegrecki K. J., Cheung H. Y. C., Yang M., Cheung H., Siddiqui J., Ahn J. H., Huynh R., Lam Y. H., Afzal M., Ong B. S., Chua M. Y. M., Ly K., Thomson J. E., Watson D., Dawson A. C., Drane A., Van Ruyven S., Lun E. W. Y., Ferguson M., Jeong J. Y., De Silva C., Wills V., Gundara J., McCourt E., Bong C., Tabone R., Wong W. J., Gray A., Koh D., Pollock M., Singhal S., Smith R., Dudi-Venkata N. N., Kanhere H., Stranz C., Seow W., Mansour L. T., Wormald J., Loveday B. P. T., Thomson B., O'Donnell T., Milenkovski N., Herath M., Trochsler M., Farfus A., Maddern G., Bunjo Z., Kuan L. L., Atanasov G., Dawson A., Lun E., Samadov E., Namazov I., Asgarov M., Ibrahimli A., Srinivasan M., Saeed M. F., Aljawder H., Juma I., Coimbra F. J., Marques N., Casteleins W. A., Petruzziello A., Jabur G., Rodriguez J. F. P., Buso P. L., Mackenzie S., Hsiao M., Sljivic I., Tecson A., Karanicolas P. J., Roke R., Moon J., Butler E. V., Riquelme F., Yanez M., Catan F., Uribe M., Carriel F., Oppliger F., Paredes A., Daroch D., Aguayo J. C., Perez Rivera C. J., Acosta Buitrago L. M., Kadamani Abiyomaa A., Mosquera Paz M. S., Cabrera P., Corso J., Ozcay N., Ozant A., Arslan K., Besim H., Almezghwi H., Azzam A. Y., Bessa S., El-Sayes I., Badawy A., Wael M., El-Gendi A., Azab M. A., Fayed M., El Kassas M., Gamal M., Tawheed A., Al Shafie A., Emile S., Elfallal A., Elfeki H., Shalaby M., Sakr A., Elbahnasawy M., Shama M., Abdel-Elsalam W., Abd-Elsalam S., Escobar Dominguez J. E., Medrano F., Gaitan S., Escalon Gonzalez O. M., Alfaro Varela J. C., Cea M., Interiano M., Cabrera B., Lakkis Z., Georges P., Antonot C., Magnin J., Kamphues C., Lauscher J. C., Schineis C., Loch F. N., Lee L. D., Beyer K., Bouchagier K., Galanis I., Bartziotas D., Lostoridis E., Tourountzi P., Nagorni E. A., Charalabopoulos A., Baili E., Kyros E., Vagios I., Skotsimara A., Liakakos T., Alexandrou A., Papalampros A., Papadopolous V., Tooulias A., Kentarchos I., Christou C., Tsoulfas G., Tale-Rosales L. F., Lopez Muralles I., Melendez H., Bran G., Monroy Mahecha F. A., Contreras J. R., Porras D. E., Paiz E., Soto E. R., Ixcayau Hernandez J. R., Gupta A., Rajput D., Kumar N., Mani R., Kant R., Sonkar A. A., Anand A., Agrawal M. K., Gaurav K., Tripathi M., Sikora S., Bharathy K., Kumar Rangapa M., Khuller D. S., Bhojwwani R., Ayyar S., Jain N., Mehraj A., Hussain F., Nazir I., Shah M., Chowdri N. A., Hilmi A., Argenio G., Atelli P., Palladino E., Armellino M. F., Tamini N., Nespoli L. C., Degrate L., Angrisani M., Carissimi F., Bordoni P., Fleres F., Clarizia G., Spolini A., Franzini M., Cucinotta E., Badessi G., Mazzeo C., Viscosi F., Pintabona G., Campagnaro T., Poletto E., Turri G., Ruzzenente A., Conci S., Guglielmi A., Feo C., Fabbri N., Fazzin M., Giaccari S., Feo C. V., Massani M., Pelizzo P., Colella M., Tutino R., Cappellacci F., Medas F., Canu G. L., Erdas E., Calo P. G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Germani P., Giunta C., Biloslavo A., Abdallah H., Aizza G., Barberis A., Belli F., Santoliquido M., Filauro M., Canonico G., Nelli T., Di Martino C., Capezzuoli L., Anastasi A., Bressan L., Cortinovis S., Nagliati C., Colombo F., Ferrario L., Bondurri A., Guerci C., Maffioli A., Catena F., Perrone G., Giuffrida M., Morini A., Annicchiarico A., Gallo G., Carpino A., Ferrari F., De Paola G., Sammarco G., Callari C., Licari L., Sorce V., Di Miceli D., Lovisetto F., Zonta S., Chessa A., Fiorini A., De Manzoni Garberini A., Angelini E., Moggia E., Murgese A., Mungo S., Birolo S. L., Garino M., Pipitone Federico N. S., Muratore A., Lunghi E. G., Calabro M., Cianci P., Enrico R., Capuzzolo S., Cafagna L., Minafra M., Sasia D., Gattolin A., Migliore M., Rimonda R., Travaglio E., De Marco G., Elter C., Bargellini T., D'Amico S., Zambonin D., Caponi A., Calini G., Puggioni A., Bresadola V., Zalla T., Cantafio S., Feroci F., Romoli L., Giudicissi R., Picciariello A., Papagni V., Dibra R., Altomare D. F., Pinotti E., Montuori M., Baronio G., Tonini V., Sartarelli L., Gori A., Cervellera M., Lapolla P., Sapienza P., Brachini G., Cirillo B., Zambon M., Mingoli A., Pascariello A., Boccia L., Benedetti S., Mantovani G., De Angelis M., Ferrara F., Testa V., Borghi F., Maione F., Pruiti Ciarello V., Giraudo G., Agresta F., Cestaro G., Prando D., Cavallo F., Zese M., Cillara N., Sechi R., Cardia R., Cannavera A., Putzu G., Frongia F., Pisanu A., Delogu D., Esposito G., Podda M., Iossa A., De Angelis F., Boru C., Silecchia G., Palini G. M., Garulli G., Veneroni S., Tammaro P., Maida P., Leake P. A., Wanliss M. G., Sato K., Chiyonobu N., Imamura H., Yamazaki S., Watanabe M., Qasem A., Ayasra F., Al Dahabrh S., Khaled A., Alsaafin S., Al-Thunaibat A., Olaywah D., Alqudah S., Alqawasmi S., Khamees A., Guboug A., Es Salim M., Althwabteh T., Bani Khaled H., El-Hammuri N., Aljesrawi A., Alamaadany F., Eljareh M., Al Gasi A. E. J., Alsaeiti S., Alkhafeefi A. S., Suliaman T., Alanasri A. H. A., Haroun A. B. A., Haron A., Kilani A. I., Ahmed M., Alawami M., Alawami A., Albashri M., Abusannuga M., Malek A., Jwaili N., Aldenfria A., Elzwawi F., Almugaddami A., Egdeer A. S. A., Masoud M., Alazzabi B., Alezabi B., Shuwayyah A., Alkamkhe A. A. S., Aboulqasim I., Atiyah H., Alfagi R. A. A., Abdulmula A., Bouhuwaish A., Samer A., Salim R., Aboazamazem H., Almiqlash B., Biala M., Alganimi W., Ghamgh R., Ben Omar N., Alsoufi A., Aldreawi M., Saleim N., Sowan F., Saleem H., Ahmed A., Samalavicius N. E., Aliosin O., Dailidenas S., Dulskas A., Buckus B., Kuliesius Z., Bradunaite R., Dominguez-Rosado I., Buerba G. A., Posadas-Trujillo O. E., Alfaro-Goldaracena A., Cortes R., Mercado M. A., Beristain-Hernandez J. L., Mora-Munoz V. S., Mena-Bedolla J. M., Palacios Ramirez A. R., Astorga Medina M. M., Van Aert G., Ombashi S., Spillenaar Bilgen R., Vos D., Besselink M., Alberts V., Busch O., Bemelman W., Boermeester M., Daams F., Gordinou De Gouberville M., Van Duijvendijk P., De Graaff M., Baaij J., Gans S., Bos K., Goudsmit B., Den Dekker B., Braat A., Kuijpers A., Breukers S., Borel Rinkes I., Andel D., Hayes T., Carson D., Bhat S., Van Der Have J., Anderson C., Bissett I., Windsor J., Elliott B. M., Scowcroft H., McLauchlan J., Ritchie D., Jeffery F., Connor S., Xu W., Mashlan H., Thirayan V., Ly J., McGuinness M. J., Ferguson L., Watt I., Harmston C., Akinmade A., Enoch E., Kayode-Nissi V., Ogundele I., Ayoade B. A., Adekoya A., Nwokoro C., Opadeyi A., Yusuf A., Ojajuni A., Adepoju O., Muhammad Dauda M., Keffi Mubarak M., Lawal K., Muhammad D., Salonga D., Sael N. A., Rey C. M., Pestano M., Tan D., Bangayan N. R., Sy D. K., Ang D., Bernardo E., Chua J. P., Alharthi M., Bukhari W., Bakier Mohammed K., Al Athath S., Ghunaim M., Saiedi H., Sultan N., Farsi A., Basendowah M., Malibary N., Jaloun H., Altalhi D., Organjee A., Moamena M., Al Zaidi T. M., Alyami M., Alqannas M., Al-Urfan M., Elawad A., Alawadhi A., Alalawi Y., Alqarni A., Alqahtani B., Alayed A., Alsobaie K., Adi H., Elhaj M., Dehlawi A., Behairy G., Khaled I., Kmezic S., Radenkovic D., Aleksic L., Markovic V., Pejovic I., Antic A., Kalkan M., Vujanovic Gadjanski O., Dusan S., Marcetic B., Thiruchelvam N., Chiow A. K. H., Lee L. S., Mun D. Y. C., Tan E. K., Koh Y. X., Loh W. L., Wang Z., Chan C. Y., Kloppers C., Almgla N., Bernon M., Kahn M., Karimbocus N., Roldan Villavicencio J. I., Goitia V., Gutierrez Rios R. D., Garcia Ruiz S., Lopez Deogracias M., Turrado-Rodriguez V., Morales X., Hessheimer A., Termes Serra R., Beltran De Heredia J., Trujillo-Diaz J., Herreros-Rodriguez J., Montes-Manrique M., De Andres-Asenjo B., Beltran-Heredia J., Gimenez Maurel T., Utrilla Fornals A., Martin Anoro L. F., Cortese S., Perez Diaz M. D., Ballon M., Morote M., Cebolla Rojas L., Oliver Guillen J. R., Lopez De Fernandez A., Del Campo Lavilla M., Mora-Guzman I., Escartin A., Pinillos A., Vela Polanco F. F., Jara Quezada J. H., Muriel Alvarez P., Tur-Martinez J., Camps J., Herrero E., Garcia-Domingo M. I., Cugat Andorra E., Crespi Mir A., Claramonte Bellmunt O., Vicens Arbona J. C., Fernandez Burgos I. R., Sarriugarte Lasarte A., Marin H., Tellaeche De La Iglesia M., Ocerin Alganza O., Salinas Gomez J., Ramos-Martin P., Urbieta A., Nasimi Sabbagh R., Castell Gomez J. T., Serrablo A., Paterna -Lopez S., GutiCrossed D SignCopyrightrrez-Diez M., Abadia-Forcen M. T., Serradilla-Martin M., Duran Munoz-Cruzado V. M., Pareja Ciuro F., Perea Del Pozo E., Aparicio Sanchez D., Dios-Barbeito S., Marenco De La Cuadra B., Retamar Gentil M., Reguera-Rosal J., Infantes Ormad M., Lopez-Ruiz J. A., Landaluce-Olavarria A., Zevallos-Quiroz J. C., Barrutia Leonardo J., Emaldi A., Begona E., Balciscueta Coltell I., Sebastian M., Martinez Ramos S., Martinez Alcaide S., Lorenzo Perez J., Martinez Insfran L. A., Lopez-Morales P., Gimenez Frances C., Rahy-Martin A., Pelloni M., Ortiz-Lopez D., Benet-Munoz O., Pinero-Gonzalez L., Alconchel F., Nicolas-Lopez T., Rodrigues K., Cascales Campos P. A., Gomez-Bosch F., Ramirez Romero P., Ibrahim M., Hamid H. K. S., Idres R., Idris M., Mohammed O., Ayran S., Sinan A. H., Ozben V., Aytac E., Aliyeva Z., Mutlu A. U., Bilgin I. A., Karahasanoglu T., Hamzaoglu I., Bozkirli B., Uprak T. K., Kotan T., Coskun M., Kara Y., Somuncu E., Kocatas A., Bozkurt M. A., Demirli Atici S., Kaya T., Sert I., Emiroglu M., Jaffar M., Younis M. U., Aziz T., Ikram F., Sandal M., Al Madhloum Al Suwaidi F., Alshaikh M. O., Saber A., Khammas A., Nessa A., Jardine R., Nicol L., Clark C., McGee A., Alkari B., Feretis M., Antakia R., Georgiades F., Moneim J., O'Neill R., Balakrishnan A., Lunevicius R., Sud A., Moutsos I., Gomez D., Shahid S., Majeed T., Ibrahim W. K. G., Kadum K., Melia R., Magee C., Chicken D. W., Kumar S., Alshibshoubi M., Van Laarhoven S., Dewi F., Williams J., Byrne B., Wilkerson P., Tang C. B., Farhangmehr N., Jonas A., Charavanamuttu V., Almeida K., Efthimiou E., Boardley J., White A., Butt M. A., Menzies D., Gundkalli Z., Hassanzadeh-Baboli D., Jones O., Mistry P., Saha S., Gerrard A., Evans J., Rajeev S., Ali W., Ross E., Gilliam A., Hitchins C., Emslie K., Spellar K., Sked H., Briggs C., Brown L., A Hemadasa N., Apollos J. R., Belgaumkar A., Tawfik A., Brewin L., Oyewole B., Wadhawan H., Massie E., Rutherford D., McGivern K., McElroy L., De'Ath H. 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R., Karmarkar R., Crockett E., Evans L., Appleton B., Griffiths E., Dada O., Kulkarni R., Albirnawi H., Gravestock P., Vincenti C., Taribagil S., Dent B., Tse C., Clayton B., Burdekin E., Bannister L., Alam I., Gray J., Mactier M., Pollock A., Gough V., Kanchustambam S. R., Ridgway M., Arujunan K., Gopalswamy S., Monteiro De Barros J., Lyons T., Griffith D., Awan A. K., Latif J., Bandlamudi N., Bhatti I., Raptis D. A., Machairas N., Pissanou T., Mestre-Costa J., Hidalgo Salinas C., Pollok J. M., Al-Ardah M., Watson-Jones E., Rontree-Carey T., Boyce T., Hawkin P., Elmaradny A., Ross K., Adu-Peprah E., Pinto K., Dunne D., McCready R., Nita G., Szatmary P., Tay V. L., Rajput K., Rajendran I., Chaudhury M., Zambas G., Swaminathan C., Atif Q. A. A., Barrow T., Williams O., Malik A., Conroy S., Lindley S., Gilmore K., Boden E., Richards S. K., Hraishawi I., Polak P., McLaughlin D., Deeny D., Shuttleworth R., Harris A., Peilober-Richardson A., Morris G. 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M., Galea M., Jeyakumar J., Marriott P., Zafar S., Baker A., Yershov D., Galanopoulos G., Jordan R., Peinado Garcia C., Anyaugo N., Bath M. F., Omatseye J., Roberts L., Argyriou E. O., Machesney M., Parmar C., Clark S., Khalil H., Unsworth S., Mlotshwa M., Ayoub N., Aboelkhair A., Iosif E., Mohamed N., Reynolds E., Mackender E., Robinson D., Mufti W., Fischkoff K., Coleman N., Anantha Sathyanarayana S., Deutsch G., Giangola M., Lin D., Weiss M., Chung C., Nguyen A., Mueller J., Dabit M., Gordon J., McGuire E., Rashid O., Georgi E., Gallo M., Kunstman J. W., Peters N. V., O'Connor R., Bhattacharya B., Onkendi E., Santos A. P., Richmond R., Warren M., Zhang K., Broderick R., Clary B., Horgan S., Doucet J., Liepert A., Harmon L., McCall C., Sham J. G., Williams E., Labadie K. P., Clark N. M., Dickerson L. K., Hammill C. W., Williams G., Kushner B., Cos H., Zarate Rodriguez J., Bailey K., Al-Raimi I. M. 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A., Adekoya A., Nwokoro C., Opadeyi A., Yusuf A., Ojajuni A., Adepoju O., Muhammad Dauda M., Keffi Mubarak M., Lawal K., Muhammad D., Salonga D., Sael N. A., Rey C. M., Pestano M., Tan D., Bangayan N. R., Sy D. K., Ang D., Bernardo E., Chua J. P., Alharthi M., Bukhari W., Bakier Mohammed K., Al Athath S., Ghunaim M., Saiedi H., Sultan N., Farsi A., Basendowah M., Malibary N., Jaloun H., Altalhi D., Organjee A., Moamena M., Al Zaidi T. M., Alyami M., Alqannas M., Al-Urfan M., Elawad A., Alawadhi A., Alalawi Y., Alqarni A., Alqahtani B., Alayed A., Alsobaie K., Adi H., Elhaj M., Dehlawi A., Behairy G., Khaled I., Kmezic S., Radenkovic D., Aleksic L., Markovic V., Pejovic I., Antic A., Kalkan M., Vujanovic Gadjanski O., Dusan S., Marcetic B., Thiruchelvam N., Chiow A. K. H., Lee L. S., Mun D. Y. C., Tan E. K., Koh Y. X., Loh W. L., Wang Z., Chan C. Y., Kloppers C., Almgla N., Bernon M., Kahn M., Karimbocus N., Roldan Villavicencio J. I., Goitia V., Gutierrez Rios R. D., Garcia Ruiz S., Lopez Deogracias M., Turrado-Rodriguez V., Morales X., Hessheimer A., Termes Serra R., Beltran De Heredia J., Trujillo-Diaz J., Herreros-Rodriguez J., Montes-Manrique M., De Andres-Asenjo B., Beltran-Heredia J., Gimenez Maurel T., Utrilla Fornals A., Martin Anoro L. F., Cortese S., Perez Diaz M. D., Ballon M., Morote M., Cebolla Rojas L., Oliver Guillen J. R., Lopez De Fernandez A., Del Campo Lavilla M., Mora-Guzman I., Escartin A., Pinillos A., Vela Polanco F. F., Jara Quezada J. H., Muriel Alvarez P., Tur-Martinez J., Camps J., Herrero E., Garcia-Domingo M. I., Cugat Andorra E., Crespi Mir A., Claramonte Bellmunt O., Vicens Arbona J. C., Fernandez Burgos I. R., Sarriugarte Lasarte A., Marin H., Tellaeche De La Iglesia M., Ocerin Alganza O., Salinas Gomez J., Ramos-Martin P., Urbieta A., Nasimi Sabbagh R., Castell Gomez J. T., Serrablo A., Paterna -Lopez S., GutiCrossed D SignCopyrightrrez-Diez M., Abadia-Forcen M. T., Serradilla-Martin M., Duran Munoz-Cruzado V. M., Pareja Ciuro F., Perea Del Pozo E., Aparicio Sanchez D., Dios-Barbeito S., Marenco De La Cuadra B., Retamar Gentil M., Reguera-Rosal J., Infantes Ormad M., Lopez-Ruiz J. A., Landaluce-Olavarria A., Zevallos-Quiroz J. C., Barrutia Leonardo J., Emaldi A., Begona E., Balciscueta Coltell I., Sebastian M., Martinez Ramos S., Martinez Alcaide S., Lorenzo Perez J., Martinez Insfran L. A., Lopez-Morales P., Gimenez Frances C., Rahy-Martin A., Pelloni M., Ortiz-Lopez D., Benet-Munoz O., Pinero-Gonzalez L., Alconchel F., Nicolas-Lopez T., Rodrigues K., Cascales Campos P. A., Gomez-Bosch F., Ramirez Romero P., Ibrahim M., Hamid H. K. S., Idres R., Idris M., Mohammed O., Ayran S., Sinan A. H., Ozben V., Aytac E., Aliyeva Z., Mutlu A. U., Bilgin I. A., Karahasanoglu T., Hamzaoglu I., Bozkirli B., Uprak T. K., Kotan T., Coskun M., Kara Y., Somuncu E., Kocatas A., Bozkurt M. A., Demirli Atici S., Kaya T., Sert I., Emiroglu M., Jaffar M., Younis M. U., Aziz T., Ikram F., Sandal M., Al Madhloum Al Suwaidi F., Alshaikh M. O., Saber A., Khammas A., Nessa A., Jardine R., Nicol L., Clark C., McGee A., Alkari B., Feretis M., Antakia R., Georgiades F., Moneim J., O'Neill R., Balakrishnan A., Lunevicius R., Sud A., Moutsos I., Gomez D., Shahid S., Majeed T., Ibrahim W. K. G., Kadum K., Melia R., Magee C., Chicken D. W., Kumar S., Alshibshoubi M., Van Laarhoven S., Dewi F., Williams J., Byrne B., Wilkerson P., Tang C. B., Farhangmehr N., Jonas A., Charavanamuttu V., Almeida K., Efthimiou E., Boardley J., White A., Butt M. A., Menzies D., Gundkalli Z., Hassanzadeh-Baboli D., Jones O., Mistry P., Saha S., Gerrard A., Evans J., Rajeev S., Ali W., Ross E., Gilliam A., Hitchins C., Emslie K., Spellar K., Sked H., Briggs C., Brown L., A Hemadasa N., Apollos J. R., Belgaumkar A., Tawfik A., Brewin L., Oyewole B., Wadhawan H., Massie E., Rutherford D., McGivern K., McElroy L., De'Ath H. D., Tobbal M., Nagendram S., Patel P., Handa S., Houghton G., Sundaralingam S. S., Parker J., Morgan R., Gala T., Ibrahim S., Harby R., Abdelkarim M., Holroyd D., Thomas R., McLennan E., Boardley R., Jamieson N. B., Ebied H., Gossage J., Davies A., Wheatstone S., Jawad Z., Jiao L., Rajagopal P., Sodergren M., Lami M., Wiberg A., Bond-Smith G., Gemmill E., Lenzi E., Sapre D., Herrod P., Boyd-Carson H., Garcea G., Issa E., Jackson A., Fashina T., Pan H., Farquharson B., Shafiq H., Emanuel O., Mahdi S., Jeyarajah S., Finch L., Whiting G., Pigott L., Martin J., Siriwardena A. K., Beatson K., Abawi L., Lam W., Rea W., Andrews B., Al-Sarireh B., Soliman F., Burridge J., Jenvey C., Hammoda M., Hollyman M., Merker L., Richards J., Sukumaran V., Rogers S., Payne C., Bibi S., Raza K., Ul Ain N., Dronamraju S., Patil S., Nachimuthu S., Ravindran S., Patel S., Ivanov B., Patel M., Ejtehadi F., Jebamani J., Akhter Rahman M. M., Woodun H., De Prendergast A., Afzal A., Bota E., Abdul S. R., Karmarkar R., Crockett E., Evans L., Appleton B., Griffiths E., Dada O., Kulkarni R., Albirnawi H., Gravestock P., Vincenti C., Taribagil S., Dent B., Tse C., Clayton B., Burdekin E., Bannister L., Alam I., Gray J., Mactier M., Pollock A., Gough V., Kanchustambam S. R., Ridgway M., Arujunan K., Gopalswamy S., Monteiro De Barros J., Lyons T., Griffith D., Awan A. K., Latif J., Bandlamudi N., Bhatti I., Raptis D. A., Machairas N., Pissanou T., Mestre-Costa J., Hidalgo Salinas C., Pollok J. M., Al-Ardah M., Watson-Jones E., Rontree-Carey T., Boyce T., Hawkin P., Elmaradny A., Ross K., Adu-Peprah E., Pinto K., Dunne D., McCready R., Nita G., Szatmary P., Tay V. L., Rajput K., Rajendran I., Chaudhury M., Zambas G., Swaminathan C., Atif Q. A. A., Barrow T., Williams O., Malik A., Conroy S., Lindley S., Gilmore K., Boden E., Richards S. K., Hraishawi I., Polak P., McLaughlin D., Deeny D., Shuttleworth R., Harris A., Peilober-Richardson A., Morris G. C., Sara X., Almourad H., Ang Y., Smyth R., Ding D., Foster J., Bond A., Kumar Y., Ahmad A., Radoi D., Alkaili-Alyamani A., Balakrishnan S., Satchidanand R. Y., Danwaththa Liyanage A. S., Blake I., Ransome M., Weerasinghe C., Kenington C., Mayo K., Mohammed M., Cockbain A. J., Peckham-Cooper A., McCauley G., Gordon C., Smith A., Hawkins W., Chakravartty S., Baillie C., Kenny R., Kumar A., Koimtzis G., Bellamy E., Menon A., Kanakala A., Nevins E. J., Madhavan A., Thulasiraman S., France K., O'Connor A., Idama D., Raslan C., Sridhar S., Parveen M., Mubashar T., Jarvis S., Cakmak I., Wright C., Andrews S., Abdelsaid K Abdul Aal Y., Jayasankar B., Morilla J., Shehata M., Subba N., Tewari N., El-Sayed C., Somaie D., Beheiry N., Douka E., Arumugam S., Wijetunga I., Leivers E., Ibrahim B., Khan K., Wheat J., Christopher J., Barnett R., Elberm H., Booker J., Ashai S., Berry D., Luhmann A., Sgro A., Rashid M. M., Galea M., Jeyakumar J., Marriott P., Zafar S., Baker A., Yershov D., Galanopoulos G., Jordan R., Peinado Garcia C., Anyaugo N., Bath M. F., Omatseye J., Roberts L., Argyriou E. O., Machesney M., Parmar C., Clark S., Khalil H., Unsworth S., Mlotshwa M., Ayoub N., Aboelkhair A., Iosif E., Mohamed N., Reynolds E., Mackender E., Robinson D., Mufti W., Fischkoff K., Coleman N., Anantha Sathyanarayana S., Deutsch G., Giangola M., Lin D., Weiss M., Chung C., Nguyen A., Mueller J., Dabit M., Gordon J., McGuire E., Rashid O., Georgi E., Gallo M., Kunstman J. W., Peters N. V., O'Connor R., Bhattacharya B., Onkendi E., Santos A. P., Richmond R., Warren M., Zhang K., Broderick R., Clary B., Horgan S., Doucet J., Liepert A., Harmon L., McCall C., Sham J. G., Williams E., Labadie K. P., Clark N. M., Dickerson L. K., Hammill C. W., Williams G., Kushner B., Cos H., Zarate Rodriguez J., Bailey K., Al-Raimi I. M. N., Al-Zazay K., Ahmed Mohammed Al-Mahdi S., Mohammed Aldowbli S., Al-Shehari M., Shream S., Al-Ameri S., Aeed M., Aldawbali M., Alsayadi R., and Alsayadi M.

Abstract

https://www.scopus.com/record/display.uri?eid=2-s2.0-85138595712&origin=inward&txGid=728c82ff11b9726b5d443216a91e7ffa#:~:text=Background: This study,of this pandemic.

Published
2022

24. Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity

Author

Guirguis, AA, Ofir-Rosenfeld, Y, Knezevic, K, Blackaby, W, Hardick, D, Chan, Y-C, Motazedian, A, Gillespie, A, Vassiliadis, D, Lam, EYN, Tran, K, Andrews, B, Harbour, ME, Vasiliauskaite, L, Saunders, CJ, Tsagkogeorga, G, Azevedo, A, Obacz, J, Pilka, ES, Carkill, M, Macpherson, L, Wainwright, EN, Liddicoat, B, Blyth, BJ, Albertella, MR, Rausch, O, Dawson, MA, Guirguis, AA, Ofir-Rosenfeld, Y, Knezevic, K, Blackaby, W, Hardick, D, Chan, Y-C, Motazedian, A, Gillespie, A, Vassiliadis, D, Lam, EYN, Tran, K, Andrews, B, Harbour, ME, Vasiliauskaite, L, Saunders, CJ, Tsagkogeorga, G, Azevedo, A, Obacz, J, Pilka, ES, Carkill, M, Macpherson, L, Wainwright, EN, Liddicoat, B, Blyth, BJ, Albertella, MR, Rausch, O, and Dawson, MA

Abstract

UNLABELLED: Therapies that enhance antitumor immunity have altered the natural history of many cancers. Consequently, leveraging nonoverlapping mechanisms to increase immunogenicity of cancer cells remains a priority. Using a novel enzymatic inhibitor of the RNA methyl-transferase METTL3, we demonstrate a global decrease in N6-methyladenosine (m6A) results in double-stranded RNA (dsRNA) formation and a profound cell-intrinsic interferon response. Through unbiased CRISPR screens, we establish dsRNA-sensing and interferon signaling are primary mediators that potentiate T-cell killing of cancer cells following METTL3 inhibition. We show in a range of immunocompetent mouse models that although METTL3 inhibition is equally efficacious to anti-PD-1 therapy, the combination has far greater preclinical activity. Using SPLINTR barcoding, we demonstrate that anti-PD-1 therapy and METTL3 inhibition target distinct malignant clones, and the combination of these therapies overcomes clones insensitive to the single agents. These data provide the mole-cular and preclinical rationale for employing METTL3 inhibitors to promote antitumor immunity in the clinic. SIGNIFICANCE: This work demonstrates that METTL3 inhibition stimulates a cell-intrinsic interferon response through dsRNA formation. This immunomodulatory mechanism is distinct from current immunotherapeutic agents and provides the molecular rationale for combination with anti-PD-1 immune-checkpoint blockade to augment antitumor immunity. This article is featured in Selected Articles from This Issue, p. 2109.

Published
2023

25. Global overview of the management of acute cholecystitis during the COVID-19 pandemic (CHOLECOVID study)

Author

Spiers H. V. M., Kouli O., Ahmed W. U., Varley R., Ahari D., Argus L., McLean K. A., Kamarajah S. K., Coe P., Griffiths E. A., Chan A. K. C., Macutkiewicz C., Jamdar S., Wilson M., Fullwood C., Toogood G., McLean K., Ahmed W., Gilchrist A., Goldsworthy M., Rashid M., Pockney P., Varela J., Brindl N., Ramirez J., Marafante C., Iwao Y., Ghzawi A., Elhadi M., Gacaferi H., Varghese C., Adeyeye A., Alser O., Teh C., Prieto M., Hasan A., Al-Naggar H., Salgado R., Veracierto F., Lancelotti T., Solinas D., Oddi R., Garcia F. W., Mazza Diez E., Andrade Ramirez M. R., Bracco R., Fernandez D., Maraschio M. A., Obeide L., Giordano E., Alcaraz A., Marani M. A., Aguirre N., Luna F., Francesconi M., Chiham F., Ramos Cossio R., Alvarez F. A., Pantoja Pachajoa D. A., Mandojana F., Merlo I. G., Gonzalez M. H., Cervelo G., Puma R., Vardaro G. F., Davis A., Jurat D., Guenoff C., Raubenheimer K., Goddard K., Brown K., Wegrecki K. J., Cheung H. Y. C., Yang M., Cheung H., Siddiqui J., Ahn J. H., Huynh R., Lam Y. H., Afzal M., Ong B. S., Chua M. Y. M., Ly K., Thomson J. E., Watson D., Dawson A. C., Drane A., Van Ruyven S., Lun E. W. Y., Ferguson M., Jeong J. Y., De Silva C., Wills V., Gundara J., McCourt E., Bong C., Tabone R., Wong W. J., Gray A., Koh D., Pollock M., Singhal S., Smith R., Dudi-Venkata N. N., Kanhere H., Stranz C., Seow W., Mansour L. T., Wormald J., Loveday B. P. T., Thomson B., O'Donnell T., Milenkovski N., Herath M., Trochsler M., Farfus A., Maddern G., Bunjo Z., Kuan L. L., Atanasov G., Dawson A., Lun E., Samadov E., Namazov I., Asgarov M., Ibrahimli A., Srinivasan M., Saeed M. F., Aljawder H., Juma I., Coimbra F. J., Marques N., Casteleins W. A., Petruzziello A., Jabur G., Rodriguez J. F. P., Buso P. L., Mackenzie S., Hsiao M., Sljivic I., Tecson A., Karanicolas P. J., Roke R., Moon J., Butler E. V., Riquelme F., Yanez M., Catan F., Uribe M., Carriel F., Oppliger F., Paredes A., Daroch D., Aguayo J. C., Perez Rivera C. J., Acosta Buitrago L. M., Kadamani Abiyomaa A., Mosquera Paz M. S., Cabrera P., Corso J., Ozcay N., Ozant A., Arslan K., Besim H., Almezghwi H., Azzam A. Y., Bessa S., El-Sayes I., Badawy A., Wael M., El-Gendi A., Azab M. A., Fayed M., El Kassas M., Gamal M., Tawheed A., Al Shafie A., Emile S., Elfallal A., Elfeki H., Shalaby M., Sakr A., Elbahnasawy M., Shama M., Abdel-Elsalam W., Abd-Elsalam S., Escobar Dominguez J. E., Medrano F., Gaitan S., Escalon Gonzalez O. M., Alfaro Varela J. C., Cea M., Interiano M., Cabrera B., Lakkis Z., Georges P., Antonot C., Magnin J., Kamphues C., Lauscher J. C., Schineis C., Loch F. N., Lee L. D., Beyer K., Bouchagier K., Galanis I., Bartziotas D., Lostoridis E., Tourountzi P., Nagorni E. A., Charalabopoulos A., Baili E., Kyros E., Vagios I., Skotsimara A., Liakakos T., Alexandrou A., Papalampros A., Papadopolous V., Tooulias A., Kentarchos I., Christou C., Tsoulfas G., Tale-Rosales L. F., Lopez Muralles I., Melendez H., Bran G., Monroy Mahecha F. A., Contreras J. R., Porras D. E., Paiz E., Soto E. R., Ixcayau Hernandez J. R., Gupta A., Rajput D., Kumar N., Mani R., Kant R., Sonkar A. A., Anand A., Agrawal M. K., Gaurav K., Tripathi M., Sikora S., Bharathy K., Kumar Rangapa M., Khuller D. S., Bhojwwani R., Ayyar S., Jain N., Mehraj A., Hussain F., Nazir I., Shah M., Chowdri N. A., Hilmi A., Argenio G., Atelli P., Palladino E., Armellino M. F., Tamini N., Nespoli L. C., Degrate L., Angrisani M., Carissimi F., Bordoni P., Fleres F., Clarizia G., Spolini A., Franzini M., Cucinotta E., Badessi G., Mazzeo C., Viscosi F., Pintabona G., Campagnaro T., Poletto E., Turri G., Ruzzenente A., Conci S., Guglielmi A., Feo C., Fabbri N., Fazzin M., Giaccari S., Feo C. V., Massani M., Pelizzo P., Colella M., Tutino R., Cappellacci F., Medas F., Canu G. L., Erdas E., Calo P. G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Germani P., Giunta C., Biloslavo A., Abdallah H., Aizza G., Barberis A., Belli F., Santoliquido M., Filauro M., Canonico G., Nelli T., Di Martino C., Capezzuoli L., Anastasi A., Bressan L., Cortinovis S., Nagliati C., Colombo F., Ferrario L., Bondurri A., Guerci C., Maffioli A., Catena F., Perrone G., Giuffrida M., Morini A., Annicchiarico A., Gallo G., Carpino A., Ferrari F., De Paola G., Sammarco G., Callari C., Licari L., Sorce V., Di Miceli D., Lovisetto F., Zonta S., Chessa A., Fiorini A., De Manzoni Garberini A., Angelini E., Moggia E., Murgese A., Mungo S., Birolo S. L., Garino M., Pipitone Federico N. S., Muratore A., Lunghi E. G., Calabro M., Cianci P., Enrico R., Capuzzolo S., Cafagna L., Minafra M., Sasia D., Gattolin A., Migliore M., Rimonda R., Travaglio E., De Marco G., Elter C., Bargellini T., D'Amico S., Zambonin D., Caponi A., Calini G., Puggioni A., Bresadola V., Zalla T., Cantafio S., Feroci F., Romoli L., Giudicissi R., Picciariello A., Papagni V., Dibra R., Altomare D. F., Pinotti E., Montuori M., Baronio G., Tonini V., Sartarelli L., Gori A., Cervellera M., Lapolla P., Sapienza P., Brachini G., Cirillo B., Zambon M., Mingoli A., Pascariello A., Boccia L., Benedetti S., Mantovani G., De Angelis M., Ferrara F., Testa V., Borghi F., Maione F., Pruiti Ciarello V., Giraudo G., Agresta F., Cestaro G., Prando D., Cavallo F., Zese M., Cillara N., Sechi R., Cardia R., Cannavera A., Putzu G., Frongia F., Pisanu A., Delogu D., Esposito G., Podda M., Iossa A., De Angelis F., Boru C., Silecchia G., Palini G. M., Garulli G., Veneroni S., Tammaro P., Maida P., Leake P. A., Wanliss M. G., Sato K., Chiyonobu N., Imamura H., Yamazaki S., Watanabe M., Qasem A., Ayasra F., Al Dahabrh S., Khaled A., Alsaafin S., Al-Thunaibat A., Olaywah D., Alqudah S., Alqawasmi S., Khamees A., Guboug A., Es Salim M., Althwabteh T., Bani Khaled H., El-Hammuri N., Aljesrawi A., Alamaadany F., Eljareh M., Al Gasi A. E. J., Alsaeiti S., Alkhafeefi A. S., Suliaman T., Alanasri A. H. A., Haroun A. B. A., Haron A., Kilani A. I., Ahmed M., Alawami M., Alawami A., Albashri M., Abusannuga M., Malek A., Jwaili N., Aldenfria A., Elzwawi F., Almugaddami A., Egdeer A. S. A., Masoud M., Alazzabi B., Alezabi B., Shuwayyah A., Alkamkhe A. A. S., Aboulqasim I., Atiyah H., Alfagi R. A. A., Abdulmula A., Bouhuwaish A., Samer A., Salim R., Aboazamazem H., Almiqlash B., Biala M., Alganimi W., Ghamgh R., Ben Omar N., Alsoufi A., Aldreawi M., Saleim N., Sowan F., Saleem H., Ahmed A., Samalavicius N. E., Aliosin O., Dailidenas S., Dulskas A., Buckus B., Kuliesius Z., Bradunaite R., Dominguez-Rosado I., Buerba G. A., Posadas-Trujillo O. E., Alfaro-Goldaracena A., Cortes R., Mercado M. A., Beristain-Hernandez J. L., Mora-Munoz V. S., Mena-Bedolla J. M., Palacios Ramirez A. R., Astorga Medina M. M., Van Aert G., Ombashi S., Spillenaar Bilgen R., Vos D., Besselink M., Alberts V., Busch O., Bemelman W., Boermeester M., Daams F., Gordinou De Gouberville M., Van Duijvendijk P., De Graaff M., Baaij J., Gans S., Bos K., Goudsmit B., Den Dekker B., Braat A., Kuijpers A., Breukers S., Borel Rinkes I., Andel D., Hayes T., Carson D., Bhat S., Van Der Have J., Anderson C., Bissett I., Windsor J., Elliott B. M., Scowcroft H., McLauchlan J., Ritchie D., Jeffery F., Connor S., Xu W., Mashlan H., Thirayan V., Ly J., McGuinness M. J., Ferguson L., Watt I., Harmston C., Akinmade A., Enoch E., Kayode-Nissi V., Ogundele I., Ayoade B. A., Adekoya A., Nwokoro C., Opadeyi A., Yusuf A., Ojajuni A., Adepoju O., Muhammad Dauda M., Keffi Mubarak M., Lawal K., Muhammad D., Salonga D., Sael N. A., Rey C. M., Pestano M., Tan D., Bangayan N. R., Sy D. K., Ang D., Bernardo E., Chua J. P., Alharthi M., Bukhari W., Bakier Mohammed K., Al Athath S., Ghunaim M., Saiedi H., Sultan N., Farsi A., Basendowah M., Malibary N., Jaloun H., Altalhi D., Organjee A., Moamena M., Al Zaidi T. M., Alyami M., Alqannas M., Al-Urfan M., Elawad A., Alawadhi A., Alalawi Y., Alqarni A., Alqahtani B., Alayed A., Alsobaie K., Adi H., Elhaj M., Dehlawi A., Behairy G., Khaled I., Kmezic S., Radenkovic D., Aleksic L., Markovic V., Pejovic I., Antic A., Kalkan M., Vujanovic Gadjanski O., Dusan S., Marcetic B., Thiruchelvam N., Chiow A. K. H., Lee L. S., Mun D. Y. C., Tan E. K., Koh Y. X., Loh W. L., Wang Z., Chan C. Y., Kloppers C., Almgla N., Bernon M., Kahn M., Karimbocus N., Roldan Villavicencio J. I., Goitia V., Gutierrez Rios R. D., Garcia Ruiz S., Lopez Deogracias M., Turrado-Rodriguez V., Morales X., Hessheimer A., Termes Serra R., Beltran De Heredia J., Trujillo-Diaz J., Herreros-Rodriguez J., Montes-Manrique M., De Andres-Asenjo B., Beltran-Heredia J., Gimenez Maurel T., Utrilla Fornals A., Martin Anoro L. F., Cortese S., Perez Diaz M. D., Ballon M., Morote M., Cebolla Rojas L., Oliver Guillen J. R., Lopez De Fernandez A., Del Campo Lavilla M., Mora-Guzman I., Escartin A., Pinillos A., Vela Polanco F. F., Jara Quezada J. H., Muriel Alvarez P., Tur-Martinez J., Camps J., Herrero E., Garcia-Domingo M. I., Cugat Andorra E., Crespi Mir A., Claramonte Bellmunt O., Vicens Arbona J. C., Fernandez Burgos I. R., Sarriugarte Lasarte A., Marin H., Tellaeche De La Iglesia M., Ocerin Alganza O., Salinas Gomez J., Ramos-Martin P., Urbieta A., Nasimi Sabbagh R., Castell Gomez J. T., Serrablo A., Paterna -Lopez S., GutiCrossed D SignCopyrightrrez-Diez M., Abadia-Forcen M. T., Serradilla-Martin M., Duran Munoz-Cruzado V. M., Pareja Ciuro F., Perea Del Pozo E., Aparicio Sanchez D., Dios-Barbeito S., Marenco De La Cuadra B., Retamar Gentil M., Reguera-Rosal J., Infantes Ormad M., Lopez-Ruiz J. A., Landaluce-Olavarria A., Zevallos-Quiroz J. C., Barrutia Leonardo J., Emaldi A., Begona E., Balciscueta Coltell I., Sebastian M., Martinez Ramos S., Martinez Alcaide S., Lorenzo Perez J., Martinez Insfran L. A., Lopez-Morales P., Gimenez Frances C., Rahy-Martin A., Pelloni M., Ortiz-Lopez D., Benet-Munoz O., Pinero-Gonzalez L., Alconchel F., Nicolas-Lopez T., Rodrigues K., Cascales Campos P. A., Gomez-Bosch F., Ramirez Romero P., Ibrahim M., Hamid H. K. S., Idres R., Idris M., Mohammed O., Ayran S., Sinan A. H., Ozben V., Aytac E., Aliyeva Z., Mutlu A. U., Bilgin I. A., Karahasanoglu T., Hamzaoglu I., Bozkirli B., Uprak T. K., Kotan T., Coskun M., Kara Y., Somuncu E., Kocatas A., Bozkurt M. A., Demirli Atici S., Kaya T., Sert I., Emiroglu M., Jaffar M., Younis M. 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P., McLaughlin D., Deeny D., Shuttleworth R., Harris A., Peilober-Richardson A., Morris G.C., Sara X., Almourad H., Ang Y., Smyth R., Ding D., Foster J., Bond A., Kumar Y., Ahmad A., Radoi D., Alkaili-Alyamani A., Balakrishnan S., Satchidanand R.Y., Danwaththa Liyanage A.S., Blake I., Ransome M., Weerasinghe C., Kenington C., Mayo K., Mohammed M., Cockbain A.J., Peckham-Cooper A., McCauley G., Gordon C., Smith A., Hawkins W., Chakravartty S., Baillie C., Kenny R., Kumar A., Koimtzis G., Bellamy E., Menon A., Kanakala A., Nevins E.J., Madhavan A., Thulasiraman S., France K., O'Connor A., Idama D., Raslan C., Sridhar S., Parveen M., Mubashar T., Jarvis S., Cakmak I., Wright C., Andrews S., Abdelsaid K Abdul Aal Y., Jayasankar B., Morilla J., Shehata M., Subba N., Tewari N., El-Sayed C., Somaie D., Beheiry N., Douka E., Arumugam S., Wijetunga I., Leivers E., Ibrahim B., Khan K., Wheat J., Christopher J., Barnett R., Elberm H., Booker J., Ashai S., Berry D., Luhmann A., Sgro A., Rashid M.M., Galea M., Jeyakumar J., Marriott P., Zafar S., Baker A., Yershov D., Galanopoulos G., Jordan R., Peinado Garcia C., Anyaugo N., Bath M.F., Omatseye J., Roberts L., Argyriou E.O., Machesney M., Parmar C., Clark S., Khalil H., Unsworth S., Mlotshwa M., Ayoub N., Aboelkhair A., Iosif E., Mohamed N., Reynolds E., Mackender E., Robinson D., Mufti W., Fischkoff K., Coleman N., Anantha Sathyanarayana S., Deutsch G., Giangola M., Lin D., Weiss M., Chung C., Nguyen A., Mueller J., Dabit M., Gordon J., McGuire E., Rashid O., Georgi E., Gallo M., Kunstman J.W., Peters N.V., O'Connor R., Bhattacharya B., Onkendi E., Santos A.P., Richmond R., Warren M., Zhang K., Broderick R., Clary B., Horgan S., Doucet J., Liepert A., Harmon L., McCall C., Sham J.G., Williams E., Labadie K.P., Clark N.M., Dickerson L.K., Hammill C.W., Williams G., Kushner B., Cos H., Zarate Rodriguez J., Bailey K., Al-Raimi I.M.N., Al-Zazay K., Ahmed Mohammed Al-Mahdi S., Mohammed Aldowbli S., Al-Shehari M., Shream S., Al-Ameri S., Aeed M., Aldawbali M., Alsayadi R., Alsayadi M., Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, AII - Infectious diseases, Graduate School, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, Spiers, H, Kouli, O, Ahmed, W, Varley, R, Ahari, D, Argus, L, Mclean, K, Kamarajah, S, Coe, P, Griffiths, E, Chan, A, Macutkiewicz, C, Jamdar, S, Wilson, M, Fullwood, C, Toogood, G, Gilchrist, A, Goldsworthy, M, Rashid, M, Pockney, P, Varela, J, Brindl, N, Ramirez, J, Marafante, C, Iwao, Y, Ghzawi, A, Elhadi, M, Gacaferi, H, Varghese, C, Adeyeye, A, Alser, O, Teh, C, Prieto, M, Hasan, A, Al-Naggar, H, Salgado, R, Veracierto, F, Lancelotti, T, Solinas, D, Oddi, R, Garcia, F, Mazza Diez, E, Andrade Ramirez, M, Bracco, R, Fernandez, D, Maraschio, M, Obeide, L, Giordano, E, Alcaraz, A, Marani, M, Aguirre, N, Luna, F, Francesconi, M, Chiham, F, Ramos Cossio, R, Alvarez, F, Pantoja Pachajoa, D, Mandojana, F, Merlo, I, Gonzalez, M, Cervelo, G, Puma, R, Vardaro, 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Mackender, E., Robinson, D., Mufti, W., Fischkoff, K., Coleman, N., Anantha Sathyanarayana, S., Deutsch, G., Giangola, M., Lin, D., Weiss, M., Chung, C., Nguyen, A., Mueller, J., Dabit, M., Gordon, J., McGuire, E., Rashid, O., Georgi, E., Gallo, M., Kunstman, J W, Peters, N V, O'Connor, R., Bhattacharya, B., Onkendi, E., Santos, A P, Richmond, R., Warren, M., Zhang, K., Broderick, R., Clary, B., Horgan, S., Doucet, J., Liepert, A., Harmon, L., McCall, C., Sham, J G, Williams, E., Labadie, K P, Clark, N M, Dickerson, L K, Hammill, C W, Williams, G., Kushner, B., Cos, H., Zarate Rodriguez, J., Bailey, K., Al-Raimi, Imn, Al-Zazay, K., Ahmed Mohammed Al-Mahdi, S., Mohammed Aldowbli, S., Al-Shehari, M., Shream, S., Al-Ameri, S., Aeed, M., Aldawbali, M., Alsayadi, R., and Alsayadi, M.

Subjects
Pandemic, SARS-CoV-2, acute cholecystitis, COVID-19, management, Cholecystitis, Acute, acute, General Medicine, pandemics, cholecystectomy, humans, cholecystitis, Cholecystectomy, Humans, Pandemics, Settore MED/18 - Chirurgia Generale, Human
Abstract

Background This study provides a global overview of the management of patients with acute cholecystitis during the initial phase of the COVID-19 pandemic. Methods CHOLECOVID is an international, multicentre, observational comparative study of patients admitted to hospital with acute cholecystitis during the COVID-19 pandemic. Data on management were collected for a 2-month study interval coincident with the WHO declaration of the SARS-CoV-2 pandemic and compared with an equivalent pre-pandemic time interval. Mediation analysis examined the influence of SARS-COV-2 infection on 30-day mortality. Results This study collected data on 9783 patients with acute cholecystitis admitted to 247 hospitals across the world. The pandemic was associated with reduced availability of surgical workforce and operating facilities globally, a significant shift to worse severity of disease, and increased use of conservative management. There was a reduction (both absolute and proportionate) in the number of patients undergoing cholecystectomy from 3095 patients (56.2 per cent) pre-pandemic to 1998 patients (46.2 per cent) during the pandemic but there was no difference in 30-day all-cause mortality after cholecystectomy comparing the pre-pandemic interval with the pandemic (13 patients (0.4 per cent) pre-pandemic to 13 patients (0.6 per cent) pandemic; P = 0.355). In mediation analysis, an admission with acute cholecystitis during the pandemic was associated with a non-significant increased risk of death (OR 1.29, 95 per cent c.i. 0.93 to 1.79, P = 0.121). Conclusion CHOLECOVID provides a unique overview of the treatment of patients with cholecystitis across the globe during the first months of the SARS-CoV-2 pandemic. The study highlights the need for system resilience in retention of elective surgical activity. Cholecystectomy was associated with a low risk of mortality and deferral of treatment results in an increase in avoidable morbidity that represents the non-COVID cost of this pandemic.

Published
2022

26. Quantification of Telmisartan and Azelnidipine Combination in Using Liquid Chromatography: Stability studies.

Author

ANDREWS, B. S. A., ABBARAJU, V. D. N. KUMAR, LAKSHMAN, SHAIK, V., SREERAM, and VIJAYALAKSHMI, KANCHARLA

Subjects
LIQUID chromatography, TELMISARTAN, DRUG stability, RF values (Chromatography), HIGH performance liquid chromatography
Abstract

A stability-indicating RP-HPLC method for the development of Telmisartan (TTN) and Azelnidipine (ADN) is analyzed in tablet dosage form. The quantification of TTN and ADN combination is done by Supel cosil C18 column (250 mm, 4.6 mm, & 5 µm). Isocratic mobile phase had mobile phase consists of 0.10M Na2SO4(pH 3.6) and acetonitrile (pH 3.6) as 55:45v/v. For this analysis flow rate is measured as 1.00 mL/minute. Wavelength is identified as 258nm to examine TTN and ADN. Stability for both these drugs under distinctive environments were performed. Injected volume is 10 µL. Run time is 8 minute. Retention time is 2.8 and 3.7 respectively. The responses were linear in the concentrate range as 37.4-110.3 for TTN and 2.24-10.51 µg/mL for ADN respectively. Percent comparative standard deviance to precision is 0.193% for TTN, 0.195% for ADN. Percent assay to accuracy for both these drugs are 98.76% and 99.04% respectively. LOD values for TTN and ADN were 0.020 µg/mL and 0.065 µg/mL and LOQ values for TTN and ADN were 0.009 µg/mL and 0.031 µg/mL. Robustness studies revealed that this method is robust by percent comparative standard deviance. This stability-indicating RP-HPLC procedure to both TTN, ADN analysis is more simple, highly sensitive, more precise, highly specific and robust, making it appropriate to the assessment of TTN and ADN in formulation. [ABSTRACT FROM AUTHOR]

Published
2023
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28. The discontinuance of low carbon digital products and services

Author

Vrain, E, Wilson, C, and Andrews, B

Subjects
Management of Technology and Innovation, Business and International Management, Applied Psychology
Abstract

Digital consumer innovations offer low-carbon alternatives to mainstream consumption practices. We address a lack of research on the factors influencing post-adoption decisions of discontinuance for this important class of innovations. We conducted a repeat survey with UK consumers (n = 995) in 2019 and 2020 to investigate 16 digital products and services across mobility, food, homes, and energy domains. Our survey captured temporal changes in adoption, personal and contextual characteristics, social influences, innovation experiences and perceived attributes. We also provide a unique contribution by assessing the impacts of Covid-19 on post-adoption processes. Our results indicate that discontinuance is associated with: 1) services more than products; 2) perceived functional attributes not met by experienced attributes; 3) a lack of positive social influence, including word-of-mouth; 4) a lack of social network connections to other adopters; and 5) a decline in an individual's financial situation. Covid-19 was not found to be a significant factor influencing innovation discontinuance. Findings highlight generalisable insights regarding issues that need addressing to overcome discontinuance. For example, while digital services offer low-carbon promise, continued adoption is sensitive to their strong performance attributes. There is a need for continued innovation to sustain market position relative to more familiar incumbents.

Published
2022

33. Imaging cell biology

Author

Andrews, B., Chang, J.B., Collinson, L., Li, D., Lundberg, E., Mahamid, J., Manley, S., Mhlanga, M.M.K., Nakano, A., Schöneberg, J., Valen, D. Van, Wu, T., Zaritsky, A., Andrews, B., Chang, J.B., Collinson, L., Li, D., Lundberg, E., Mahamid, J., Manley, S., Mhlanga, M.M.K., Nakano, A., Schöneberg, J., Valen, D. Van, Wu, T., and Zaritsky, A.

Abstract

Contains fulltext : 284072.pdf (Publisher’s version ) (Closed access)

Published
2022

34. The need for a roadmap to guide actions for Aboriginal and Torres Strait Islander adolescent health: youth governance as an essential foundation.

Author

Westhead, S, Appleby, Q, Andrews, B, Brodie, T, Brown, A, Canuto, K, Cooke, J, Garay, M, Harrington, T, Hunter, D, Kennedy, C, Lenoy, J, Lester, O, McCleary, H, Pearson, O, Randall, L, Reilly, R, Rose, H, Rosendale, D, Telfer, J, Azzopardi, P, Westhead, S, Appleby, Q, Andrews, B, Brodie, T, Brown, A, Canuto, K, Cooke, J, Garay, M, Harrington, T, Hunter, D, Kennedy, C, Lenoy, J, Lester, O, McCleary, H, Pearson, O, Randall, L, Reilly, R, Rose, H, Rosendale, D, Telfer, J, and Azzopardi, P

Published
2022

35. The discontinuance of low carbon digital products and services

Author

Vrain, E., Wilson, C., Andrews, B., Vrain, E., Wilson, C., and Andrews, B.

Abstract

Digital consumer innovations offer low-carbon alternatives to mainstream consumption practices. We address a lack of research on the factors influencing post-adoption decisions of discontinuance for this important class of innovations. We conducted a repeat survey with UK consumers (n = 995) in 2019 and 2020 to investigate 16 digital products and services across mobility, food, homes, and energy domains. Our survey captured temporal changes in adoption, personal and contextual characteristics, social influences, innovation experiences and perceived attributes. We also provide a unique contribution by assessing the impacts of Covid-19 on post-adoption processes. Our results indicate that discontinuance is associated with: 1) services more than products; 2) perceived functional attributes not met by experienced attributes; 3) a lack of positive social influence, including word-of-mouth; 4) a lack of social network connections to other adopters; and 5) a decline in an individual's financial situation. Covid-19 was not found to be a significant factor influencing innovation discontinuance. Findings highlight generalisable insights regarding issues that need addressing to overcome discontinuance. For example, while digital services offer low-carbon promise, continued adoption is sensitive to their strong performance attributes. There is a need for continued innovation to sustain market position relative to more familiar incumbents.

Published
2022
Full Text
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38. Drivers of Precipitation Change: An Energetic Understanding

Author

Richardson, T. B, Forster, P. M, Andrews, B, Boucher, O, Faluvegi, G, Flashner, D, Hodnebrog, O, Kasoar, M, Kirkevag, A, Lamarque, J.-F, Myhre, G, Olivie, D, B. H. Samset, Shawki, D, Shindell, D, Takemure, T, and Voulgarakis, A

Subjects
Meteorology And Climatology
Abstract

The response of the hydrological cycle to climate forcings can be understood within the atmospheric energy budget framework. In this study precipitation and energy budget responses to five forcing agents are analyzed using 10 climate models from the Precipitation Driver Response Model Intercomparison Project (PDRMIP). Precipitation changes are split into a forcing-dependent fast response and a temperature-driven hydrological sensitivity. Globally, when normalized by top-of-atmosphere (TOA) forcing, fast precipitation changes are most sensitive to strongly absorbing drivers (CO2, black carbon). However, over land fast precipitation changes are most sensitive to weakly absorbing drivers (sulfate, solar) and are linked to rapid circulation changes. Despite this, land-mean fast responses to CO2 and black carbon exhibit more intermodel spread. Globally, the hydrological sensitivity is consistent across forcings, mainly associated with increased longwave cooling, which is highly correlated with intermodel spread. The land-mean hydrological sensitivity is weaker, consistent with limited moisture availability. The PDRMIP results are used to construct a simple model for land-mean and sea-mean precipitation change based on sea surface temperature change and TOA forcing. The model matches well with CMIP5 ensemble mean historical and future projections, and is used to understand the contributions of different drivers. During the twentieth century, temperature-driven intensification of land-mean precipitation has been masked by fast precipitation responses to anthropogenic sulfate and volcanic forcing, consistent with the small observed trend. However, as projected sulfate forcing decreases, and warming continues, land-mean precipitation is expected to increase more rapidly, and may become clearly observable by the mid-twenty-first century.

Published
2017
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40. Optimizing satellite resources for the global assessment and mitigation of volcanic hazards—Suggestions from the USGS Powell Center Volcano Remote Sensing Working Group

Author

Pritchard, M. E., primary, Poland, M., additional, Reath, K., additional, Andrews, B., additional, Bagnardi, M., additional, Biggs, J., additional, Carn, S., additional, Coppola, D., additional, Ebmeier, S.K., additional, Furtney, M.A., additional, Girona, T., additional, Griswold, J., additional, Lopez, T., additional, Lundgren, P., additional, Ogburn, S., additional, Pavolonis, M., additional, Rumpf, E., additional, Vaughan, G., additional, Wauthier, C., additional, Wessels, R., additional, Wright, R., additional, Anderson, K.R., additional, Bato, M.G., additional, and Roman, A., additional

Published
2022
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41. Adapting the Finetech-Brindley Sacral Anterior Root Stimulator for Bioelectronic Medicine

Author

Peterken, F, Benjaber, M, Doherty, S, Perkins, T, Creasey, G, Donaldson, N, Andrews, B, and Denison, T

Subjects
Humans, Spinal Cord Injuries, Rhizotomy
Abstract

The Finetech-Brindley Sacral Anterior Root Stimulator (SARS) is a low cost and reliable system. The architecture has been used for various bioelectric treatments, including several thousand implanted systems for restoring bladder function following spinal cord injury (SCI). Extending the operational frequency range would expand the capability of the system; enabling, for example, the exploration of eliminating the rhizotomy through an electrical nerve block. The distributed architecture of the SARS system enables stimulation parameters to be adjusted without modifying the implant design or manufacturing. To explore the design degrees-of-freedom, a circuit simulation was created and validated using a modified SARS system that supported stimulation frequencies up to 600 Hz. The simulation was also used to explore high frequency (up to 30kHz) behaviour, and to determine the constraints on charge delivered at the higher rates. A key constraint found was the DC blocking capacitors, designed originally for low frequency operation, not fully discharging within a shortened stimulation period. Within these current implant constraints, we demonstrate the potential capability for higher frequency operation that is consistent with presynaptic stimulation block, and also define targeted circuit improvements for future extension of stimulation capability.

Published
2021
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43. 12351 Patient Perspectives Regarding Early Risk Counseling About Intrauterine Adhesions: A Fellow's Pelvic Research Network Study.

Author

Ramanathan, A, Hazen, N, Andrews, B, Cosgriff, LL, Sankey-Thomas, KM, Mak, F, Salazar, CA, and Robinson III, JK

Abstract

Intrauterine adhesions (IUA) cause significant morbidity including menstrual irregularities and subfertility. However, women who experience uterine instrumentation peripartum are not usually counseled about the risk and impacts of IUA. We explored the experience of women who were diagnosed and treated for IUA after a high-risk postpartum event (HRPE) and used these patient perspectives to design a counseling intervention. Mixed methods study. Minimally invasive gynecology (MIGS) academic practice. Patients were identified who underwent treatment of IUA as a result of an HRPE. Demographic and history data were obtained from chart review. A MIGS surgeon conducted ten interviews which were audio-recorded and transcribed; the transcripts were coded in NVivo 14. The MIGS surgeon developed a counseling intervention based on the interview data and led a multisite Consortium of MIGS Specialists for the Early Diagnosis of Asherman's Syndrome (COMEDAS), where the interview data and counseling intervention script were reviewed by eight MIGS specialists. 90% of patients who experienced an HRPE reported that they were never counseled about their risk of IUA at the time of the HRPE. All patients would have preferred early counseling including information regarding frequency, symptoms, risks, and treatment of IUA. 90% of patients would have wanted to receive counseling when giving consent for the HRPE, or, if the HRPE occurred emergently during delivery, prior to hospital discharge. Patients experienced delay in diagnosis and subsequent pregnancy as well as repetitive dismissal by clinicians. Patients emphasized the emotional challenges of seeking IUA diagnosis and treatment and expressed frustration at the lack of empowerment and autonomy in their reproductive healthcare. Patients have a clear desire for improved counseling regarding IUA after HRPE. Based on this data, a counseling intervention has been developed which is currently being validated in Phase 2 of this multisite FPRN study. [ABSTRACT FROM AUTHOR]

Published
2024
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