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1. Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2

Author

Brian J. Conti, Andrew S. Leicht, Robert N. Kirchdoerfer, and Michael R. Sussman

Subjects
Chemistry, QD1-999
Abstract

Nidovirus RNA synthesis machineries catalyze nucleotide transfer, but characterization of this activity is limited using existing methods. Here the nucleotidyl transferase activity of SARSCoV-2 replicase proteins is characterized by mass spectrometry of GMP and UMP protein adducts, allowing identification of nucleotidylation sites in vitro.

Published
2021
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