12 results on '"Andrew Huff"'
Search Results
2. Global health security: Radiation countermeasures for acute radiation syndrome
- Author
-
L Andrew Huff, Ayodele O Olabisi, and Vijay K Singh
- Subjects
Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2018
- Full Text
- View/download PDF
3. Overcoming barriers to restructuring in a modular visualisation environment.
- Author
-
Olav Beckmann, Anthony J. Field, Gerard Gorman, Andrew Huff, Marc Hull, and Paul H. J. Kelly
- Published
- 2004
- Full Text
- View/download PDF
4. Investigation of piezocone dissipation test interpretation in clay accounting for vertical and horizontal porewater pressure dissipation with a large deformation axisymmetric penetration model
- Author
-
Diane Moug, Andrew Huffman, and Jason T. DeJong
- Subjects
cone penetration testing ,dissipation testing ,ALE ,large deformations ,finite deformation ,overconsolidated clay ,Engineering (General). Civil engineering (General) ,TA1-2040 ,City planning ,HT165.5-169.9 - Abstract
The piezocone (CPTu) dissipation test is used to characterize how the applied load from the penetrating cone is distributed between the soil and pore fluid during both penetrometer advancement and when penetration is paused. The coefficient of consolidation is often estimated from CPTu dissipation tests by interpreting the rate of excess porewater pressure (∆u) decay to static conditions during a pause in cone penetration. Most CPTu dissipation test interpretation methods are based on Terzaghi consolidation theory for ∆u dissipation at the cone shoulder (u2 position) or cone face (u1 position) and assume that radial ∆u dissipation dominates the response. However, several recent studies show that vertical ∆u migration does contribute to the response. This study uses a large deformation direct axisymmetric cone penetration model to characterize the soil-water mechanical response during CPTu dissipation tests, and in particular, the role of vertical ∆u dissipation on the response at the u1 and u2 positions. Large deformations around the penetrating cone are accommodated with an Arbitrary Lagrangian Eulerian approach. Soil behavior is modeled with the MIT-S1 constitutive model calibrated for Boston blue clay (BBC) soil behavior. ∆u dissipation following undrained cone penetration is simulated with coupled consolidation for BBC with over-consolidation ratios (OCR) of 1, 2, and 4 and a range of hydraulic conductivity anisotropy. The simulated u1 and u2 dissipation responses are presented to study how they are affected by OCR and hydraulic conductivity anisotropy. A correction factor is recommended to account for hydraulic conductivity anisotropy when interpreting the horizontal coefficient of consolidation from CPTu dissipation tests.
- Published
- 2024
- Full Text
- View/download PDF
5. Right Cross
- Author
-
Andrew Huff and Andrew Huff
- Subjects
- Christian fiction, Suspense fiction, Spy stories
- Abstract
Heart-pounding action meets spiritual choices in this thrilling finale to John Cross's sagaFirst he left the CIA. Then he left pastoral ministry. Now John Cross has been imprisoned in one of Great Britain's most infamous prisons. Has he reached the end of his rope? Or is this another move in a dangerous spy game?Christine Lewis, United News Network's rising star television anchor, is determined to find out. But in her pursuit of answers, Christine finds herself at the center of a cyberterrorist plot to alter the balance of power in the world. From the English coastline to the Rocky Mountains, John must partner with the CIA and MI6 in a race against the clock to stop the threat of nuclear war and save the lives of everyone he holds dear.The concluding story in the Shepherd Suspense trilogy is a globe-trotting, action-packed adventure with threads of biblical truth woven in. Fans of high-octane thrillers will be on the edge of their seats with Right Cross.
- Published
- 2021
6. U.S. Department of Defense Multiple-Parameter Biodosimetry Network
- Author
-
Matthew H. Hoefer, Thad J Sharp, William F. Blakely, Selena M. Hayes, Alexander Romanyukha, H. Michael Stewart, Anthony S. Williams, Ricardo A. Reyes, and L. Andrew Huff
- Subjects
Safety Management ,Decision support system ,Computer science ,Disaster Planning ,Expert Systems ,computer.software_genre ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Radiation Protection ,0302 clinical medicine ,Biodosimetry ,Radiation Monitoring ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiation ,Modalities ,Radiological and Ultrasound Technology ,Public Health, Environmental and Occupational Health ,General Medicine ,Service member ,United States Department of Defense ,medicine.disease ,Triage ,United States ,Expert system ,Systems Integration ,Models, Organizational ,030220 oncology & carcinogenesis ,Radiological weapon ,Decision Support Systems, Management ,Biological Assay ,Medical emergency ,Radiation Accidents ,computer - Abstract
The U.S. Department of Defense (USDOD) service members are at risk of exposure to ionizing radiation due to radiation accidents, terrorist attacks and national defense activities. The use of biodosimetry is a standard of care for the triage and treatment of radiation injuries. Resources and procedures need to be established to implement a multiple-parameter biodosimetry system coupled with expert medial guidance to provide an integrated radiation diagnostic system to meet USDOD requirements. Current USDOD biodosimetry capabilities were identified and recommendations to fill the identified gaps are provided. A USDOD Multi-parametric Biodosimetry Network, based on the expertise that resides at the Armed Forces Radiobiology Research Institute and the Naval Dosimetry Center, was designed. This network based on the use of multiple biodosimetry modalities would provide diagnostic and triage capabilities needed to meet USDOD requirements. These are not available with sufficient capacity elsewhere but could be needed urgently after a major radiological/nuclear event.
- Published
- 2016
7. Global health security: Radiation countermeasures for acute radiation syndrome
- Author
-
Ayodele O. Olabisi, Vijay K. Singh, and L. Andrew Huff
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,medicine.medical_specialty ,business.industry ,lcsh:R895-920 ,medicine ,Global health ,Acute Radiation Syndrome ,Intensive care medicine ,business ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 - Published
- 2018
8. Improvements in renal function with selinexor in relapsed/refractory multiple myeloma: post-hoc analyses from the STORM study
- Author
-
Vogl, Dan T Nooka, Ajay Gavriatopoulou, Maria Yee, Andrew Huff, Carol Moreau, Philippe Dingli, David Cole, Craig Richardson, Paul G Dimopoulos, Meletios A others
- Subjects
Health Sciences ,Επιστήμες Υγείας - Published
- 2019
9. Cross Shadow
- Author
-
Andrew Huff and Andrew Huff
- Subjects
- Clergy--Fiction, Assassins--Fiction
- Abstract
All journalist Christine Lewis wants is the truth. All pastor John Cross wants is to avoid it.Former CIA agent turned evangelical pastor John Cross is busy caring for the small community of believers he ministers to in Virginia. Journalist Christine Lewis is busy with the demand for her talents from top news agencies in New York City. Neither has any time left for their relationship, which began eight months before when they paired up to prevent the detonation of a chemical bomb in the nation's capital.But when Christine hears that her stepbrother has been arrested for murder in Texas, they team up again to discover the truth about the crime. Untangling a web of conspiracy, the couple finds themselves in the center of another dangerous situation-and in trouble far deeper than they expected.With an assassin on the loose, a trusted colleague acting as a double agent, and unreliable artificial intelligence connected to mercenaries who have Cross on their hit list, these two may not get out of the Lone Star State alive.
- Published
- 2020
10. A Cross to Kill
- Author
-
Andrew Huff and Andrew Huff
- Subjects
- Christian fiction, American, Fiction, Religious fiction, Thrillers (Fiction), Suspense fiction, Christian fiction
- Abstract
A gripping debut thriller pits a man of God against terrorists--and his own deadly pastJohn Cross is a small-town pastor, bent on leading his flock to follow God's calling. He's not the sort of man one would expect to have a checkered past.But the truth is that the man behind the pulpit preaching to his sheep was once a wolf--an assassin for the CIA. When John decided to follow Christ, he put that work behind him, determined to do penance for all the lives he took. He vowed never to kill again.Now someone wants the peaceful pastor to pay for his sins with his own life. And when a terrorist out for revenge walks into the church, John's secrets are laid bare. Confronted with his past, he must face his demons and discover whether a man can truly change. Can he keep his vow--even when the people he loves are in mortal danger? Will his congregation and the brave woman he's learning to care for be caught in the cross fire? In the end, John's life may be the only sacrifice he has left to offer... Andrew Huff's thrilling debut is not only a riveting story of suspense, it's also a deep exploration of the moral quandaries that face those who choose to follow the Prince of Peace in a violent world.
- Published
- 2019
11. First Global Consensus for Evidence-Based Management of the Hematopoietic Syndrome Resulting From Exposure to Ionizing Radiation
- Author
-
Jeffrey Nemhauser, Rita Schneider, Leif Stenke, Nelson Valverde, C. Norman Coleman, Alla Shapiro, Ray Powles, Judith L. Bader, Nicholas Dainiak, Douglas B. White, Martin Hauer-Jensen, Zhanat Carr, Patricia K. Lillis-Hearne, Robert Nicolas Gent, Joseph Albanese, Arnold Ganser, Holger J. Schünemann, David M. Weinstock, Nelson J. Chao, E. Buglova, Claude Gorin, Viktor Meineke, Kazuhiko Maekawa, and L. Andrew Huff
- Subjects
medicine.medical_specialty ,Consensus ,medicine.medical_treatment ,MEDLINE ,Psychological intervention ,Hematopoietic stem cell transplantation ,Article ,law.invention ,Randomized controlled trial ,law ,Radiation, Ionizing ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,Intensive care medicine ,Evidence-Based Medicine ,business.industry ,Public Health, Environmental and Occupational Health ,Evidence-based management ,Acute Radiation Syndrome ,Evidence-based medicine ,Granulocyte colony-stimulating factor ,Immunology ,Cytokines ,business ,Stem Cell Transplantation - Abstract
Objective:Hematopoietic syndrome (HS) is a clinical diagnosis assigned to people who present with ≥1 new-onset cytopenias in the setting of acute radiation exposure. The World Health Organization convened a panel of experts to evaluate the evidence and develop recommendations for medical countermeasures for the management of HS in a hypothetical scenario involving the hospitalization of 100 to 200 individuals exposed to radiation. The objective of this consultancy was to develop recommendations for treatment of the HS based upon the quality of evidence.Methods:English-language articles were identified in MEDLINE and PubMed. Reference lists of retrieved articles were distributed to panel members before the meeting and updated during the meeting. Published case series and case reports of individuals with HS, published randomized controlled trials of relevant interventions used to treat nonirradiated individuals, reports of studies in irradiated animals, and prior recommendations of subject matter experts were selected. Studies were extracted using the Grading of Recommendations Assessment Development and Evaluation (GRADE) system. In cases in which data were limited or incomplete, a narrative review of the observations was made. No randomized controlled trials of medical countermeasures have been completed for individuals with radiation-associated HS. The use of GRADE analysis of countermeasures for injury to hematopoietic tissue was restricted by the lack of comparator groups in humans. Reliance on data generated in nonirradiated humans and experimental animals was necessary.Results:Based upon GRADE analysis and narrative review, a strong recommendation was made for the administration of granulocyte colony-stimulating factor or granulocyte macrophage colony-stimulating factor and a weak recommendation was made for the use of erythropoiesis-stimulating agents or hematopoietic stem cell transplantation.Conclusions:Assessment of therapeutic interventions for HS in humans exposed to nontherapeutic radiation is difficult because of the limits of the evidence.(Disaster Med Public Health Preparedness. 2011;5:202-212)
- Published
- 2011
12. Literature Review and Global Consensus on Management of Acute Radiation Syndrome Affecting Nonhematopoietic Organ Systems
- Author
-
Judith L. Bader, Jeffrey Nemhauser, Martin Hauer-Jensen, Arnold Ganser, Holger J. Schünemann, Robert Nicolas Gent, C. Norman Coleman, Alla Shapiro, Viktor Meineke, E. Buglova, Nicholas Dainiak, Nelson J. Chao, Leif Stenke, Nelson Valverde, Claude Gorin, Ray Powles, Rita Schneider, Joseph Albanese, Kazuhiko Maekawa, Douglas B. White, Zhanat Carr, Patricia K. Lillis-Hearne, David M. Weinstock, and L. Andrew Huff
- Subjects
medicine.medical_specialty ,Palliative care ,business.industry ,Consensus Development Conferences as Topic ,Critical Illness ,Public Health, Environmental and Occupational Health ,MEDLINE ,Acute Radiation Syndrome ,World Health Organization ,Skin Diseases ,United States ,Optimal management ,World health ,Critical illness ,medicine ,Humans ,Intensive care medicine ,business ,Expert Testimony ,Organ system ,Skin - Abstract
Objectives:The World Health Organization convened a panel of experts to rank the evidence for medical countermeasures for management of acute radiation syndrome (ARS) in a hypothetical scenario involving the hospitalization of 100 to 200 victims. The goal of this panel was to achieve consensus on optimal management of ARS affecting nonhematopoietic organ systems based upon evidence in the published literature.Methods:English-language articles were identified in MEDLINE and PubMed. Reference lists of retrieved articles were distributed to conferees in advance of and updated during the meeting. Published case series and case reports of ARS, publications of randomized controlled trials of relevant interventions used to treat nonirradiated individuals, reports of studies in irradiated animals, and prior recommendations of subject matter experts were selected. Studies were extracted using the Grading of Recommendations Assessment Development and Evaluation system. In cases in which data were limited or incomplete, a narrative review of the observations was made.Results:No randomized controlled trials of medical countermeasures have been completed for individuals with ARS. Reports of countermeasures were often incompletely described, making it necessary to rely on data generated in nonirradiated humans and in experimental animals. A strong recommendation is made for the administration of a serotonin-receptor antagonist prophylactically when the suspected exposure is >2 Gy and topical steroids, antibiotics, and antihistamines for radiation burns, ulcers, or blisters; excision and grafting of radiation ulcers or necrosis with intractable pain; provision of supportive care to individuals with neurovascular syndrome; and administration of electrolyte replacement therapy and sedatives to individuals with significant burns, hypovolemia, and/or shock. A strong recommendation is made against the use of systemic steroids in the absence of a specific indication. A weak recommendation is made for the use of fluoroquinolones, bowel decontamination, loperamide, and enteral nutrition, and for selective oropharyngeal/digestive decontamination, blood glucose maintenance, and stress ulcer prophylaxis in critically ill patients.Conclusions:High-quality studies of therapeutic interventions in humans exposed to nontherapeutic radiation are not available, and because of ethical concerns regarding the conduct of controlled studies in humans, such studies are unlikely to emerge in the near future.(Disaster Med Public Health Preparedness. 2011;5:183–201)
- Published
- 2011
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.