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3. Autorinnen und Autoren

Author

Andresen, Viola, primary, Berlit, Peter, additional, Bingel, Ulrike, additional, Burger, Michael, additional, Daniels, Christine, additional, Deuschl, Günther, additional, Diener, Cristoph, additional, Eckstein, Hans-Henning, additional, Elger, Christian E., additional, Erbguth, Frank, additional, Eyüpoglu, Ilker, additional, Faissner, Simon, additional, Fink, Gereon R., additional, Forsting, Michael, additional, Gold, Ralf, additional, Goldbrunner, Roland, additional, Heuß, Dieter F., additional, Jeub, Monika, additional, Jordan, Berit, additional, Kastrup, Oliver, additional, Klein, Matthias, additional, Kleine-Borgmann, Julian, additional, Kovac, Stjepana, additional, Kuramatsu, Joji B., additional, Layer, Peter, additional, Lehmann, Helmar C., additional, Limmroth, Volker, additional, Neuneier, Janina, additional, Nickenig, Georg, additional, Onur, Özgür, additional, Pfister, Hans-Walter, additional, Schlamann, Marc, additional, Schneider-Gold, Christiane, additional, Scholz, Martin, additional, Schwab, Stefan, additional, Sommer, Christof-Matthias, additional, Steinbach, Joachim, additional, Strupp, Michael, additional, Schassen, K. Henrike von, additional, Voß, Martin, additional, Wallesch, Claus-Werner, additional, and Zierz, Stephan, additional

Published
2024
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4. The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome

Author

Mohr, Sandra, Fritz, Nikola, Hammer, Christian, Martínez, Cristina, Berens, Sabrina, Schmitteckert, Stefanie, Wahl, Verena, Schmidt, Malin, Houghton, Lesley A, Goebel‐Stengel, Miriam, Kabisch, Maria, Götze, Dorothea, Milovač, Irina, D’Amato, Mauro, Zheng, Tenghao, Röth, Ralph, Mönnikes, Hubert, Engel, Felicitas, Gauss, Annika, Tesarz, Jonas, Raithel, Martin, Andresen, Viola, Frieling, Thomas, Keller, Jutta, Pehl, Christian, Stein‐Thöringer, Christoph, Clarke, Gerard, Kennedy, Paul J, Cryan, John F, Dinan, Timothy G, Quigley, Eamonn MM, Spiller, Robin, Beltrán, Caroll, Madrid, Ana María, Torres, Verónica, de Arce, Edith Pérez, Herzog, Wolfgang, Mayer, Emeran A, Sayuk, Gregory, Gazouli, Maria, Karamanolis, George, Kapur‐Pojskič, Lejla, Bustamante, Mariona, Rabionet, Raquel, Estivil, Xavier, Franke, André, Lieb, Wolfgang, Boeckxstaens, Guy, Wouters, Mira M, Simrén, Magnus, Rappold, Gudrun A, Vicario, Maria, Santos, Javier, Schaefert, Rainer, Lorenzo‐Bermejo, Justo, and Niesler, Beate

Subjects
Genetics, Chronic Pain, Neurosciences, Digestive Diseases, Pain Research, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Biomarkers, Female, Haplotypes, Humans, Intestinal Mucosa, Irritable Bowel Syndrome, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Serotonin, Serotonin Plasma Membrane Transport Proteins, 5-HT, IBS, IBS-C, serotonin transporter, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Clinical Sciences, Biochemistry & Molecular Biology
Abstract

Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanisms remain unclear. We sequenced the alternative P2 promoter driving intestinal SLC6A4 expression and identified single nucleotide polymorphisms (SNPs) that were associated with IBS in a discovery sample. Identified SNPs built different haplotypes, and the tagging SNP rs2020938 seems to associate with constipation-predominant IBS (IBS-C) in females. rs2020938 validation was performed in 1978 additional IBS patients and 6,038 controls from eight countries. Meta-analysis on data from 2,175 IBS patients and 6,128 controls confirmed the association with female IBS-C. Expression analyses revealed that the P2 promoter drives SLC6A4 expression primarily in the small intestine. Gene reporter assays showed a functional impact of SNPs in the P2 region. In silico analysis of the polymorphic promoter indicated differential expression regulation. Further follow-up revealed that the major allele of the tagging SNP rs2020938 correlates with differential SLC6A4 expression in the jejunum and with stool consistency, indicating functional relevance. Our data consolidate rs2020938 as a functional SNP associated with IBS-C risk in females, underlining the relevance of SLC6A4 in IBS pathogenesis.

Published
2021

6. The serotonin receptor 3E variant is a risk factor for female IBS-D

Author

Fritz, Nikola, Berens, Sabrina, Dong, Yuanjun, Martínez, Cristina, Schmitteckert, Stefanie, Houghton, Lesley A., Goebel-Stengel, Miriam, Wahl, Verena, Kabisch, Maria, Götze, Dorothea, D’Amato, Mauro, Zheng, Tenghao, Röth, Ralph, Mönnikes, Hubert, Tesarz, Jonas, Engel, Felicitas, Gauss, Annika, Raithel, Martin, Andresen, Viola, Keller, Jutta, Frieling, Thomas, Pehl, Christian, Stein-Thöringer, Christoph, Clarke, Gerard, Kennedy, Paul J., Cryan, John F., Dinan, Timothy G., Quigley, Eamonn M. M., Spiller, Robin, Beltrán, Caroll, Madrid, Ana María, Torres, Verónica, Mayer, Emeran A., Sayuk, Gregory, Gazouli, Maria, Karamanolis, George, Bustamante, Mariona, Estivil, Xavier, Rabionet, Raquel, Hoffmann, Per, Nöthen, Markus M., Heilmann-Heimbach, Stefanie, Schmidt, Börge, Franke, André, Lieb, Wolfgang, Herzog, Wolfgang, Boeckxstaens, Guy, Wouters, Mira M., Simrén, Magnus, Rappold, Gudrun A., Vicario, Maria, Santos, Javier, Schaefert, Rainer, Lorenzo-Bermejo, Justo, and Niesler, Beate

Published
2022
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7. Besondere Störungen

Author

Andresen, Viola, primary, Bertram, Franziska, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gottschalk, Laura, additional, Keller, Jutta, additional, Luttermann, Janek, additional, Menge, Daniela, additional, Nader, Susanne, additional, Rosien, Ulrich, additional, and Siegel, Julian, additional

Published
2023
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10. Leber

Author

Rosien, Ulrich, primary, Berg, Thomas, additional, Layer, Peter, additional, Alm, Margret, additional, Andresen, Viola, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Liedtke, Niels, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Rössle, Martin, additional, Siegel, Julian, additional, Aehling, Niklas, additional, Baumgart, Daniel C., additional, Behrens, Angelika, additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Carstensen, Johanna, additional, Greck, Marie de, additional, Ell, Christian, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fibbe, Christiane, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, von Schassen, Henrike, additional, Wolf, Susanna, additional, Wölfel, Michael, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2023
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11. Adressen

Author

Rosien, Ulrich, primary, Berg, Thomas, additional, Layer, Peter, additional, Aehling, Niklas, additional, Alm, Margret, additional, Andresen, Viola, additional, Behrens, Angelika, additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Carstensen, Johanna, additional, Greck, Marie de, additional, Ell, Christian, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Herta, Toni, additional, Jasper, Dr. med. Dorothea, additional, Keller, Jutta, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Miehlke, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Porschen, Rainer, additional, Rose, Solveig, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stallmach, Andreas, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah Lena, additional, Thiel, Stephanie, additional, Thomas-Morr, Dr. med. Julia, additional, Tillmann, Henriette, additional, Todt, Dr. med. Friederike, additional, Schassen, Henrike von, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2023
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12. Ärztliche Arbeitstechniken

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Gaus, Antonia, additional, Grandt, Daniel, additional, Jasper, Dorothea, additional, Keller, Jutta, additional, Michaelis, Stefan, additional, Pachmann, Carsten, additional, Rössle, Martin, additional, Siegel, Julian, additional, and Rosien, Ulrich, additional

Published
2023
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13. Gastroenterologische Notfälle und Leitsymptome

Author

Aehling, Niklas, primary, Andresen, Viola, additional, Berg, Thomas, additional, Böhlig, Albrecht, additional, Fritz, Korinna, additional, Herta, Toni, additional, Keller, Jutta, additional, Layer, Peter, additional, Michaelis, Stefan, additional, Rosien, Ulrich, additional, Schulz, Sebastian, additional, Wölfel, Michael, additional, Wolgast, Valentin, additional, and Zimmermann, Kathrin, additional

Published
2023
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15. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Author

Sperber, Ami D., Bangdiwala, Shrikant I., Drossman, Douglas A., Ghoshal, Uday C., Simren, Magnus, Tack, Jan, Whitehead, William E., Dumitrascu, Dan L., Fang, Xuicai, Fukudo, Shin, Kellow, John, Okeke, Edith, Quigley, Eamonn M.M., Schmulson, Max, Whorwell, Peter, Archampong, Timothy, Adibi, Payman, Andresen, Viola, Benninga, Marc A., Bonaz, Bruno, Bor, Serhat, Fernandez, Luis Bustos, Choi, Suck Chei, Corazziari, Enrico S., Francisconi, Carlos, Hani, Albis, Lazebnik, Leonid, Lee, Yeong Yeh, Mulak, Agata, Rahman, M. Masudur, Santos, Javier, Setshedi, Mashiko, Syam, Ari Fahrial, Vanner, Stephen, Wong, Reuben K., Lopez-Colombo, Aurelio, Costa, Valeria, Dickman, Ram, Kanazawa, Motoyori, Keshteli, Ammar Hassanzadeh, Khatun, Rutaba, Maleki, Iradj, Poitras, Pierre, Pratap, Nitesh, Stefanyuk, Oksana, Thomson, Sandie, Zeevenhooven, Judith, and Palsson, Olafur S.

Published
2021
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18. Funktionelle Erkrankungen

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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19. Leber

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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20. Diagnostische und therapeutische Verfahren

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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21. Proktologische Erkrankungen

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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22. Magen und Duodenum

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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23. Biliäres System

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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24. Chronisch-entzündliche Darmerkrankungen (CED)

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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26. Adressen

Author

Rosien, Ulrich, primary, Berg, Thomas, additional, Layer, Peter, additional, Aehling, Niklas, additional, Alm, Margret, additional, Andresen, Viola, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Dr. med. Johanna, additional, Greck, Marie de, additional, Ell, Christian, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dr. med. Dorothea, additional, Keller, Jutta, additional, Kipp, PH Frank, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Liedtke, Niels, additional, Luttermann, Dr. med. Janek, additional, Mancke, Lida, additional, May, Andrea, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Miehlke, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Porschen, Rainer, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Dr. med. Oliver, additional, Schulz, Dr. med. Sebastian, additional, Siegel, Julian, additional, Stallmach, Andreas, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Dr. med. Rhea, additional, Schassen, Henrike von, additional, Wolf, Susanna, additional, Wölfel, Michael, additional, Wolgast, Dr. med Valentin, additional, Wübbolding, Dr. med. Clara, additional, Zimmermann, Kathrin, additional, and Weinke, Thomas, additional

Published
2021
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27. Kolon

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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28. Dünndarm

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

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2021
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30. Infektiöse Darmerkrankungen

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

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2021
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31. Ösophagus

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

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2021
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32. Pankreas

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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33. Gastroenterologische Notfälle und Leitsymptome

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

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2021
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34. Risikomanagement in der Gastroenterologie

Author

Alm, Margret, primary, Andresen, Viola, additional, Ell, Christian, additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Keller, Jutta, additional, Frank Kipp, PH., additional, May, Andrea, additional, Miehlke, Stephan, additional, Porschen, Rainer, additional, Stallmach, Andreas, additional, Weinke, Thomas, additional, Aehling, Niklas, additional, Alm, Margret, additional, Baumgart, Daniel C., additional, Bertram, Franziska, additional, Böhlig, Albrecht, additional, Bullmann, Catharina, additional, Carstensen, Johanna, additional, de Greck, Marie, additional, Ellerbeck, Wienke, additional, Enders, Giulia, additional, Fritz, Korinna, additional, Gaus, Antonia, additional, Gottschalk, Laura, additional, Grandt, Kai Daniel, additional, Henniges, Utah-Maria, additional, Herta, Toni, additional, Jasper, Dorothea, additional, Kschowak, Nina, additional, Lang, Konstantin, additional, Lange, Alina, additional, Layer, Peter, additional, Liedtke, Niels, additional, Luttermann, Janek, additional, Mancke, Lida, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Menge, Daniela, additional, Michaelis, Stefan, additional, Nader, Sara, additional, Niedergassel, Tim-Alexander, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, Rosien, Ulrich, additional, Rössle, Martin, additional, Schellhorn, Melina, additional, Schnell, Oliver, additional, Schulz, Sebastian, additional, Siegel, Julian, additional, Stein, Alexander, additional, Szuba, Johannes, additional, Teising, Sarah, additional, Thiel, Stephanie, additional, Thomas-Morr, Julia, additional, Tillmann, Henriette, additional, Todt, Friederike, additional, Veelken, Rhea, additional, von Schassen, Henrike, additional, Wölfel, Michael, additional, Wolf, Susanna, additional, Wolgast, Valentin, additional, Wübbolding, Clara, additional, and Zimmermann, Kathrin, additional

Published
2021
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36. Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019

Author

Andresen, Viola, Becker, G., Frieling, T., Goebel-Stengel, M., Gundling, F., Herold, A., Karaus, M., Keller, J., Kim, M., Klose, P., Krammer, H., Kreis, M. E., Kuhlbusch-Zicklam, R., Langhorst, Jost, Layer, P., Lenzen-Großimlinghaus, R., Madisch, A., Mönnikes, H., Müller-Lissner, S., Rubin, D., Schemann, M., Schwille-Kiuntke, J., Stengel, A., Storr, M., van der Voort, I., Voderholzer, W., Wedel, T., Wirz, S., Witzigmann, H., and Pehl, Christian

Subjects
Medizin, Gastroenterology
Published
2022
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37. Work productivity and activity impairment in disorders of gut‐brain interaction: Data from the Rome Foundation Global Epidemiology Study

Author

Frändemark, Åsa, primary, Törnblom, Hans, additional, Hreinsson, Jóhann Páll, additional, Andresen, Viola, additional, Benninga, Marc A., additional, Corazziari, Enrico S., additional, Fukudo, Shin, additional, Mulak, Agata, additional, Santos, Javier, additional, Sperber, Ami D., additional, Bangdiwala, Shrikant I., additional, Palsson, Olafur S., additional, and Simrén, Magnus, additional

Published
2023
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41. Work productivity and activity impairment in disorders of gut-brain interaction:Data from the Rome Foundation Global Epidemiology Study

Author

Frändemark, Åsa, Törnblom, Hans, Hreinsson, J. hann P. ll, Andresen, Viola, Benninga, Marc A., Corazziari, Enrico S., Fukudo, Shin, Mulak, Agata, Santos, Javier, Sperber, Ami D., Bangdiwala, Shrikant I., Palsson, Olafur S., and Simrén, Magnus

Abstract

Background: Disorders of Gut-Brain Interaction (DGBI) are highly prevalent worldwide, but their effect on work productivity has not gained much attention. Aims and Methods: We aimed to compare work productivity and activity impairment (WPAI) in persons with and without DGBI in a large population-based cohort and identify factors independently associated with WPAI in subjects with DGBI. Data were collected from Germany, Israel, Italy, Japan, the Netherlands, Poland, Spain and Sweden via Internet surveys as part of the Rome Foundation Global Epidemiology Study. Apart from the Rome IV diagnostic questionnaire, questionnaires evaluating WPAI related to general health (WPAI:GH), psychological distress (PHQ-4), somatic symptom severity (PHQ-15) and other factors were assessed. Results: Of the 16,820 subjects, 7111 met the criteria for DGBI according to the Rome IV diagnostic questionnaire. Subjects with DGBI were younger (median (interquartile range) age 43 (31–58) vs. 47 (33–62)) and more often female (59.0% vs. 43.7%) compared to subjects without DGBI. Subjects with DGBI had higher absenteeism, presenteeism (poor work productivity due to illness), overall work impairment and activity impairment (p

Published
2023
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43. Face‐to‐face interviews versus Internet surveys: Comparison of two data collection methods in the Rome foundation global epidemiology study: Implications for population‐based research

Author

Sperber, Ami D., primary, Bor, Serhat, additional, Fang, Xuicai, additional, Bangdiwala, Shrikant I., additional, Drossman, Douglas A., additional, Ghoshal, Uday C., additional, Simren, Magnus, additional, Tack, Jan, additional, Whitehead, William E., additional, Dumitrascu, Dan L., additional, Fukudo, Shin, additional, Kellow, John, additional, Okeke, Edith, additional, Quigley, Eamonn M. M., additional, Schmulson, Max, additional, Whorwell, Peter, additional, Archampong, Timothy, additional, Adibi, Payman, additional, Andresen, Viola, additional, Benninga, Marc A., additional, Bonaz, Bruno, additional, Fernandez, Luis Bustos, additional, Choi, Suck Chei, additional, Corazziari, Enrico S., additional, Francisconi, Carlos, additional, Hani, Albis, additional, Lazebnik, Leonid, additional, Lee, Yeong Yeh, additional, Mulak, Agata, additional, Rahman, M. Masudur, additional, Santos, Javier, additional, Setshedi, Mashiko, additional, Syam, Ari Fahrial, additional, Vanner, Stephen, additional, Wong, Reuben K., additional, Lopez‐Colombo, Aurelio, additional, Costa, Valeria, additional, Dickman, Ram, additional, Kanazawa, Motoyori, additional, Keshteli, Ammar Hassanzadeh, additional, Khatun, Rutaba, additional, Maleki, Iradj, additional, Poitras, Pierre, additional, Pratap, Nitesh, additional, Stefanyuk, Oksana, additional, Thomson, Sandie, additional, Buyruk, Murat, additional, Unal, Nalan, additional, Huang, Dan, additional, Song, Jun, additional, Hreinsson, Johann P., additional, and Palsson, Olafur S., additional

Published
2023
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44. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Author

Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, H��benthal, Matthias, Abecasis, Gon��alo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, T��nu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D���Amato, Mauro, Jostins, Luke, Parkes, Miles, Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Clark, Sarah K., Elson, Sarah L., Fletez-Brant, Kipper, Fontanillas, Pierre, Furlotte, Nicholas A., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., Luff, Marie K., McCreight, Jey C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., Northover, Carrie A. M., O���Connell, Jared, Petrakovitz, Aaron A., Pitts, Steven J., Poznik, G. David, Sathirapongsasuti, J. Fah, Shastri, Anjali J., Shelton, Janie F., Tian, Chao, Tung, Joyce Y., Tunney, Robert J., Vacic, Vladimir, Wang, Xin, Zare, Amir S., Kashyap, Purna, Chang, Lin, Mayer, Emeran, Heitkemper, Margaret, Sayuk, Gregory S., Ringel-Kulka, Tamar, Ringel, Yehuda, Chey, William D., Eswaran, Shanti, Merchant, Juanita L., Shulman, Robert J., Bujanda, Luis, Garcia-Etxebarria, Koldo, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T., Karling, Pontus, Ohlsson, Bodil, Walter, Susanna, Faresj��, ��shild O., Simren, Magnus, Halfvarson, Jonas, Portincasa, Piero, Barbara, Giovanni, Usai-Satta, Paolo, Neri, Matteo, Nardone, Gerardo, Cuomo, Rosario, Galeazzi, Francesca, Bellini, Massimo, Latiano, Anna, Houghton, Lesley, Jonkers, Daisy, Kurilshikov, Alexander, Weersma, Rinse K., Netea, Mihai, Tesarz, Jonas, Gauss, Annika, Goebel-Stengel, Miriam, Andresen, Viola, Frieling, Thomas, Pehl, Christian, Schaefert, Rainer, Niesler, Beate, Lieb, Wolfgang, Hanevik, Kurt, Langeland, Nina, Wensaas, Knut-Arne, Litleskare, Sverre, Gabrielsen, Maiken E., Thomas, Laurent, Thijs, Vincent, Lemmens, Robin, Van Oudenhove, Lukas, Wouters, Mira, Eijsbouts C., Zheng T., Kennedy N.A., Bonfiglio F., Anderson C.A., Moutsianas L., Holliday J., Shi J., Shringarpure S., Agee M., Aslibekyan S., Auton A., Bell R.K., Bryc K., Clark S.K., Elson S.L., Fletez-Brant K., Fontanillas P., Furlotte N.A., Gandhi P.M., Heilbron K., Hicks B., Hinds D.A., Huber K.E., Jewett E.M., Jiang Y., Kleinman A., Lin K.-H., Litterman N.K., Luff M.K., McCreight J.C., McIntyre M.H., McManus K.F., Mountain J.L., Mozaffari S.V., Nandakumar P., Noblin E.S., Northover C.A.M., O'Connell J., Petrakovitz A.A., Pitts S.J., Poznik G.D., Sathirapongsasuti J.F., Shastri A.J., Shelton J.F., Tian C., Tung J.Y., Tunney R.J., Vacic V., Wang X., Zare A.S., Voda A.-I., Kashyap P., Chang L., Mayer E., Heitkemper M., Sayuk G.S., Ringel-Kulka T., Ringel Y., Chey W.D., Eswaran S., Merchant J.L., Shulman R.J., Bujanda L., Garcia-Etxebarria K., Dlugosz A., Lindberg G., Schmidt P.T., Karling P., Ohlsson B., Walter S., Faresjo A.O., Simren M., Halfvarson J., Portincasa P., Barbara G., Usai-Satta P., Neri M., Nardone G., Cuomo R., Galeazzi F., Bellini M., Latiano A., Houghton L., Jonkers D., Kurilshikov A., Weersma R.K., Netea M., Tesarz J., Gauss A., Goebel-Stengel M., Andresen V., Frieling T., Pehl C., Schaefert R., Niesler B., Lieb W., Hanevik K., Langeland N., Wensaas K.-A., Litleskare S., Gabrielsen M.E., Thomas L., Thijs V., Lemmens R., Van Oudenhove L., Wouters M., Farrugia G., Franke A., Hubenthal M., Abecasis G., Zawistowski M., Skogholt A.H., Ness-Jensen E., Hveem K., Esko T., Teder-Laving M., Zhernakova A., Camilleri M., Boeckxstaens G., Whorwell P.J., Spiller R., McVean G., D'Amato M., Jostins L., Parkes M., Eijsbouts, Chris [0000-0001-5179-0653], Anderson, Carl A. [0000-0003-1719-7009], Moutsianas, Loukas [0000-0001-5453-345X], Holliday, Joanne [0000-0003-4568-7320], Shringarpure, Suyash [0000-0001-6464-2668], Voda, Alexandru-Ioan [0000-0003-2974-6992], Farrugia, Gianrico [0000-0003-3473-5235], Hübenthal, Matthias [0000-0002-5956-3006], Abecasis, Gonçalo [0000-0003-1509-1825], Zawistowski, Matthew [0000-0002-3005-083X], Ness-Jensen, Eivind [0000-0001-6005-0729], Teder-Laving, Maris [0000-0002-5872-1850], Camilleri, Michael [0000-0001-6472-7514], Whorwell, Peter J. [0000-0002-5220-8474], Spiller, Robin [0000-0001-6371-4500], McVean, Gil [0000-0002-5012-4162], D’Amato, Mauro [0000-0003-2743-5197], Jostins, Luke [0000-0002-2475-3969], Parkes, Miles [0000-0002-6467-0631], Apollo - University of Cambridge Repository, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., Holliday, J., Shi, J., Shringarpure, S., Agee, M., Aslibekyan, S., Auton, A., Bell, R. K., Bryc, K., Clark, S. K., Elson, S. L., Fletez-Brant, K., Fontanillas, P., Furlotte, N. A., Gandhi, P. M., Heilbron, K., Hicks, B., Hinds, D. A., Huber, K. E., Jewett, E. M., Jiang, Y., Kleinman, A., Lin, K. -H., Litterman, N. K., Luff, M. K., Mccreight, J. C., Mcintyre, M. H., Mcmanus, K. F., Mountain, J. L., Mozaffari, S. V., Nandakumar, P., Noblin, E. S., Northover, C. A. M., O'Connell, J., Petrakovitz, A. A., Pitts, S. J., Poznik, G. D., Sathirapongsasuti, J. F., Shastri, A. J., Shelton, J. F., Tian, C., Tung, J. Y., Tunney, R. J., Vacic, V., Wang, X., Zare, A. S., Voda, A. -I., Kashyap, P., Chang, L., Mayer, E., Heitkemper, M., Sayuk, G. S., Ringel-Kulka, T., Ringel, Y., Chey, W. D., Eswaran, S., Merchant, J. L., Shulman, R. J., Bujanda, L., Garcia-Etxebarria, K., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Walter, S., Faresjo, A. O., Simren, M., Halfvarson, J., Portincasa, P., Barbara, G., Usai-Satta, P., Neri, M., Nardone, G., Cuomo, R., Galeazzi, F., Bellini, M., Latiano, A., Houghton, L., Jonkers, D., Kurilshikov, A., Weersma, R. K., Netea, M., Tesarz, J., Gauss, A., Goebel-Stengel, M., Andresen, V., Frieling, T., Pehl, C., Schaefert, R., Niesler, B., Lieb, W., Hanevik, K., Langeland, N., Wensaas, K. -A., Litleskare, S., Gabrielsen, M. E., Thomas, L., Thijs, V., Lemmens, R., Van Oudenhove, L., Wouters, M., Farrugia, G., Franke, A., Hubenthal, M., Abecasis, G., Zawistowski, M., Skogholt, A. H., Ness-Jensen, E., Hveem, K., Esko, T., Teder-Laving, M., Zhernakova, A., Camilleri, M., Boeckxstaens, G., Whorwell, P. J., Spiller, R., Mcvean, G., D'Amato, M., Jostins, L., and Parkes, M.

Subjects
Male, Molecular Chaperone, Mood Disorder, 631/208/205/2138, Biology, 692/699/1503/1502/2071, Bioinformatics, Polymorphism, Single Nucleotide, Genetic pathways, 38/43, Irritable Bowel Syndrome, Cytoskeletal Protein, Genetics, medicine, Genetic predisposition, Aged, Anxiety Disorders, CD56 Antigen, Cell Adhesion Molecules, Cytoskeletal Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Homeodomain Proteins, Humans, Middle Aged, Molecular Chaperones, Mood Disorders, United Kingdom, Polymorphism, 692/699/476, Irritable bowel syndrome, Depression (differential diagnoses), article, Homeodomain Protein, Single Nucleotide, Guanine Nucleotide Exchange Factor, medicine.disease, Neuroticism, Biobank, Mood, Cell Adhesion Molecule, Anxiety, medicine.symptom, Anxiety Disorder, Human
Abstract

Funder: Kennedy Trust Rheumatology Research Prize Studentship, Funder: DFG Cluster of Excellence ���Precision Medicine in Chronic In-flammation��� (PMI; ID: EXC2167), Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: ���Ideas��� Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772, Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNL, Funder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421, Irritable bowel syndrome (IBS) results from disordered brain���gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain���gut interactions underlying IBS.

Published
2021
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48. Adressen

Author

Layer, Peter, primary, Rosien, Ulrich, additional, Andresen, Viola, additional, Bläker, Michael, additional, Buchholtz, Anja, additional, de Greck, Marie, additional, Fibbe, Christiane, additional, Frederking, Dorothea, additional, Gaus, Antonia, additional, Göttinger, Anamur Lan, additional, Henniges, Utah-Maria, additional, Jesse, Nadine, additional, Jung, Annabelle, additional, Keck, Beate, additional, Keller, Jutta, additional, Liedtke, Niels, additional, Lingenfelser, Thomas, additional, Mancke, Lida Victoria, additional, Meier, Viola Sophie, additional, Melle, Ulrike, additional, Michaelis, Stefan, additional, Miehlke, Stephan, additional, Müller, Andreas, additional, Niedergassel, Tim Alexander, additional, Niemax, Katrin, additional, Pachmann, Carsten, additional, Rose, Solveig, additional, von Schassen, Henrike, additional, Schikora, Kristin, additional, Schulz, Sebastian, additional, Schwarz, Wolfgang, additional, Siebenhaar, Arno, additional, Siegel, Julian, additional, Szuba, Johannes, additional, Teising, Sarah Lena, additional, Thiel, Stephanie, additional, Todt, Friederike, additional, and Ulbricht, Korinna, additional

Published
2018
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50. 15 - Besondere Störungen

Author

Andresen, Viola, Bertram, Franziska, Enders, Giulia, Fritz, Korinna, Gottschalk, Laura, Keller, Jutta, Luttermann, Janek, Menge, Daniela, Nader, Susanne, Rosien, Ulrich, and Siegel, Julian

Published
2023
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