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1. Modified endoscopic vacuum therapy for the treatment of gastrointestinal fistulas and perforations: experience at State University of Campinas – Brazil

Author: Bonilha, D., additional, Monteiro, F. B., additional, Durlacher, B., additional, Diaz, R. G., additional, meirelles dos santos, J. O., additional, Andreollo, N. A., additional, Lopes, L. R., additional, and Montes, C. G., additional
Published: 2024
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2. PB0937 Association of Fibrinolytic Potential and Risk of Mortality in Cancer Patients

Author: Montalvao, S., primary, Gois, G., additional, Honorato, M., additional, Rodrigues, T., additional, Martinelli, B., additional, Carvalheira, J., additional, Andreollo, N., additional, Teixeira, J., additional, and Annichino-Bizzacchi, J., additional
Published: 2023
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3. Postoperative and Pathological Outcomes of CROSS and FLOT as Neoadjuvant Therapy for Esophageal and Junctional Adenocarcinoma: An International Cohort Study From the Oesophagogastric Anastomosis Audit (OGAA)

Author: MS CGO, Cancer, Steering Committee, Committee, Alderson, D., Bundred, J., Rpt, Evans, Gossage, J., Griffiths, E. A., Jefferies, B., Kamarajah, S. K., McKay, S., Mohamed, Nepogodiev, D., Siaw- Acheampong, K., Singh, P., Van Hillegersberg, R., Vohra, R., Wanigasooriya, K., Whitehouse, T., National Leads, Leads, Gjata, A., Moreno, J. I., Takeda, F. R., Kidane, B., Guevara Castro, R., Harustiak, T., Bekele, A., Kechagias, A., Gockel, Kennedy, A., Da Roit, A., Bagajevas, A., Azagra, J. S., Mahendran, H. A., Mejía-Fernández, L., Wijnhoven, B. P.L., El Kafsi, J., Sayyed, R. H., Sousa, M., Sampaio, A. S., Negoi, Blanco, R., Wallner, B., Schneider, P. M., Hsu, P. K., Isik, A., Leads, Site, Gananadha, S., Wills, Devadas, M., Duong, C., Talbot, M., Hii, M. W., Jacobs, R., Andreollo, N. A., Johnston, B., Darling, G., Isaza-Restrepo, A., Rosero, G., Arias-Amézquita, F., Raptis, D., Gaedcke, J., Reim, D., Izbicki, J., Egberts, J. H., Dikinis, S., Kjaer, D. W., Larsen, M. H., Achiam, M. P., Saarnio, J., Theodorou, D., Liakakos, T., Korkolis, D. P., Robb, W. B., Collins, C., Murphy, T., Reynolds, J., Tonini, Migliore, M., Bonavina, L., Valmasoni, M., Bardini, R., Weindelmayer, J., Terashima, M., White, R. E., Alghunaim, E., Elhadi, M., Leon-Takahashi, A. M., Medina-Franco, H., Lau, P. C., Okonta, K. E., Heisterkamp, J., Rosman, C., Beban, G., Babor, R., Gordon, A., Rossaak, J. I., Pal, K. M.I., Qureshi, A. U., Naqi, S. A., Syed, A. A., Barbosa, J., Vicente, C. S., Leite, J., Freire, J., Casaca, R., Costa, R. C.T., Scurtu, R. R., Mogoanta, S. S., Bolca, C., Constantinoiu, S., Sekhniaidze, D., Bjelović, M., So, J. B.Y., Gačevski, G., Loureiro, C., Pera, M., Bianchi, A., Moreno Gijón, M., Martín Fernández, J., Trugeda Carrera, M. S., Vallve-Bernal, M., Cítores Pascual, M. A., Elmahi, S., Halldestam, Hedberg, J., Mönig, S., Gutknecht, S., Tez, M., Guner, A., Tirnaksiz, M. B., Colak, E., Sevinç, B., Hindmarsh, A., Khan, Khoo, D., Byrom, R., Gokhale, J., Wilkerson, P., Jain, P., Chan, D., Robertson, K., Iftikhar, S., Skipworth, R., Forshaw, M., Higgs, S., Nijjar, R., Viswanath, Y. K.S., Turner, P., Dexter, S., Boddy, A., Allum, W. H., Oglesby, S., Cheong, E., Beardsmore, D., Maynard, N., Berrisford, R., Mercer, S., Puig, S., Melhado, R., Kelty, C., Underwood, T., Dawas, K., Lewis, W., Al-Bahrani, A., Bryce, G., Thomas, M., Arndt, A. T., Palazzo, F., Meguid, R. A., Collaborators, Fergusson, J., Beenen, E., Mosse, C., Salim, J., Cheah, S., Wright, T., Cerdeira, M. P., McQuillan, P., Richardson, M., Liem, H., Spillane, J., Yacob, M., Albadawi, F., Thorpe, T., Dingle, A., Cabalag, C., Loi, K., Fisher, O. M., Ward, S., Read, M., Johnson, M., Bassari, R., Bui, H., Cecconello, Raa, Sallum, Da Rocha, J. R.M., Lopes, L. R., Tercioti, V., Jds, Coelho, Ferrer, J. A.P., Buduhan, G., Tan, L., Srinathan, S., Shea, P., Yeung, J., Allison, F., Carroll, P., Vargas-Barato, F., Gonzalez, F., Ortega, J., Nino-Torres, L., Beltrán-García, T. C., Castilla, L., Pineda, M., Bastidas, A., Gómez-Mayorga, J., Cortés, N., Cetares, C., Caceres, S., Duarte, S., Pazdro, A., Snajdauf, M., Faltova, H., Sevcikova, M., Mortensen, P. B., Katballe, N., Ingemann, T., Kruhlikava, Morten B., Ainswort, A. P., Stilling, N. M., Eckardt, J., Holm, J., Thorsteinsson, M., Siemsen, M., Brandt, B., Nega, B., Teferra, E., Tizazu, A., Kauppila, J. H., Koivukangas, V., Meriläinen, S., Gruetzmann, R., Krautz, C., Weber, G., Golcher, H., Emons, G., Azizian, A., Ebeling, M., Niebisch, S., Kreuser, N., Albanese, G., Hesse, J., Volovnik, L., Boecher, U., Reeh, M., Triantafyllou, S., Schizas, D., Michalinos, A., Balli, E., Mpoura, M., Charalabopoulos, A., Manatakis, D. K., Balalis, D., Bolger, J., Baban, C., Mastrosimone, A., McAnena, O., Quinn, A., Ó Súilleabháin, C. B., Hennessy, M. M., Ivanovski, Khizer, H., Ravi, N., Donlon, N., Cervellera, M., Vaccari, S., Bianchini, S., Sartarelli, L., Asti, E., Bernardi, D., Merigliano, S., Provenzano, L., Scarpa, M., Saadeh, L., Salmaso, B., De Manzoni, G., Giacopuzzi, S., La Mendola, R., De Pasqual, C. A., Tsubosa, Y., Niihara, M., Irino, T., Makuuchi, R., Ishii, K., Mwachiro, M., Fekadu, A., Odera, A., Mwachiro, E., Alshehab, D., Ahmed, H. A., Shebani, A. O., Elhadi, A., Elnagar, F. A., Elnagar, H. F., Makkai-Popa, S. T., Wong, L. F., Tan, Y. R., Thannimalai, S., Ho, C. A., Pang, W. S., Tan, J. H., Hnl, Basave, Cortés-González, R., Lagarde, S. M., Van Lanschot, J. J.B., Cords, C., Jansen, W. A., Martijnse, I., Matthijsen, R., Bouwense, S., Klarenbeek, B., Verstegen, M., Van Workum, F., Ruurda, J. P., Van Der Sluis, P. C., De Maat, M., Evenett, N., Johnston, P., Patel, R., MacCormick, A., Young, M., Smith, B., Ekwunife, C., Memon, A. H., Shaikh, K., Wajid, A., Khalil, N., Haris, M., Mirza, Z. U., Sba, Qudus, Sarwar, M. Z., Shehzadi, A., Raza, A., Jhanzaib, M. H., Farmanali, J., Zakir, Z., Shakeel, O., Nasir, Khattak, S., Baig, M., Noor, M. A., Ahmed, H. H., Naeem, A., Pinho, A. C., Da Silva, R., Bernardes, A., Campos, J. C., Matos, H., Braga, T., Monteiro, C., Ramos, P., Cabral, F., Gomes, M. P., Martins, P. C., Correia, A. M., Videira, J. F., Ciuce, C., Drasovean, R., Apostu, R., Paitici, S., Racu, A. E., Obleaga, C. V., Beuran, M., Stoica, B., Negoita, Ciubotaru C., Cordos, Birla, R. D., Predescu, D., Hoara, P. A., Tomsa, R., Shneider, Agasiev, M., Ganjara, Gunjić, D., Veselinović, M., Babič, T., Chin, T. S., Shabbir, A., Kim, G., Crnjac, A., Samo, H., Díez Del Val, Del Val, Leturio, S., Ramón, J. M., Dal Cero, M., Rifá, S., Rico, M., Pagan Pomar, A., Martinez Corcoles, J. A., Rodicio Miravalles, J. L., Pais, S. A., Turienzo, S. A., Alvarez, L. S., Campos, P. V., Rendo, A. G., García, S. S., Epg, Santos, Martínez, E. T., Fernández Díaz, M. J., Magadán Álvarez, C., Martín, Concepción, Díaz López, C., Rosat Rodrigo, A., Pérez Sánchez, L. E., Bailón Cuadrado, M., Tinoco Carrasco, C., Choolani Bhojwani, E., Sánchez, D. P., Ahmed, M. E., Dzhendov, T., Lindberg, F., Rutegård, M., Sundbom, M., Mickael, C., Colucci, N., Schnider, A., Er, S., Kurnaz, E., Turkyilmaz, S., Turkyilmaz, A., Yildirim, R., Baki, B. E., Akkapulu, N., Karahan, O., Damburaci, N., Hardwick, R., Safranek, P., Sujendran, Bennett, J., Afzal, Z., Shrotri, M., Chan, B., Exarchou, K., Gilbert, T., Amalesh, T., Mukherjee, D., Mukherjee, S., Wiggins, T. H., Kennedy, R., McCain, S., Harris, A., Dobson, G., Davies, N., Wilson, I., Mayo, D., Bennett, D., Young, R., Manby, P., Blencowe, N., Schiller, M., Byrne, B., Mitton, D., Wong, V., Elshaer, A., Cowen, M., Menon, Tan, L. C., McLaughlin, E., Koshy, R., Sharp, C., Brewer, H., Das, N., Cox, M., Al Khyatt, W., Worku, D., Iqbal, R., Walls, L., McGregor, R., Fullarton, G., MacDonald, A., MacKay, C., Craig, C., Dwerryhouse, S., Hornby, S., Jaunoo, S., Wadley, M., Baker, C., Saad, M., Kelly, M., Davies, A., Di Maggio, F., Mistry, P., Singhal, R., Tucker, O., Kapoulas, S., Powell-Brett, S., Davis, P., Bromley, G., Watson, L., Verma, R., Ward, J., Shetty, V., Ball, C., Pursnani, K., Sarela, A., Sue Ling, H., Mehta, S., Hayden, J., To, N., Palser, T., Hunter, D., Supramaniam, K., Butt, Z., Ahmed, A., Kumar, S., Chaudry, A., Moussa, O., Kordzadeh, A., Wilson, M. Lorenzi B., Patil, P., Noaman, Willem, J., Bouras, G., Evans, R., Singh, M., Warrilow, H., Ahmad, A., Tewari, N., Yanni, F., Couch, J., Theophilidou, E., Reilly, J. J., Van Boxel, Gijs, Akbari, K., Zanotti, D., Sgromo, B., Sanders, G., Wheatley, T., Ariyarathenam, A., Reece-Smith, A., Humphreys, L., Choh, C., Carter, N., Knight, B., Pucher, P., Athanasiou, A., Tan, B., Abdulrahman, M., Vickers, J., Akhtar, K., Chaparala, R., Brown, R., Alasmar, M. M.A., Ackroyd, R., Patel, K., Tamhankar, A., Wyman, A., Walker, R., Grace, B., Abbassi, N., Slim, N., Ioannidi, L., Blackshaw, G., Havard, T., Escofet, X., Powell, A., Owera, A., Rashid, F., Jambulingam, P., Padickakudi, J., Ben-Younes, H., McCormack, K., Makey, I. A., Karush, M. K., Seder, C. W., Liptay, M. J., Chmielewski, G., Rosato, E. L., Berger, A. C., Zheng, R., Okolo, E., Singh, A., Scott, C. D., Weyant, M. J., Mitchell, J. D., MS CGO, Cancer, Steering Committee, Committee, Alderson, D., Bundred, J., Rpt, Evans, Gossage, J., Griffiths, E. A., Jefferies, B., Kamarajah, S. K., McKay, S., Mohamed, Nepogodiev, D., Siaw- Acheampong, K., Singh, P., Van Hillegersberg, R., Vohra, R., Wanigasooriya, K., Whitehouse, T., National Leads, Leads, Gjata, A., Moreno, J. I., Takeda, F. R., Kidane, B., Guevara Castro, R., Harustiak, T., Bekele, A., Kechagias, A., Gockel, Kennedy, A., Da Roit, A., Bagajevas, A., Azagra, J. S., Mahendran, H. A., Mejía-Fernández, L., Wijnhoven, B. P.L., El Kafsi, J., Sayyed, R. H., Sousa, M., Sampaio, A. S., Negoi, Blanco, R., Wallner, B., Schneider, P. M., Hsu, P. K., Isik, A., Leads, Site, Gananadha, S., Wills, Devadas, M., Duong, C., Talbot, M., Hii, M. W., Jacobs, R., Andreollo, N. A., Johnston, B., Darling, G., Isaza-Restrepo, A., Rosero, G., Arias-Amézquita, F., Raptis, D., Gaedcke, J., Reim, D., Izbicki, J., Egberts, J. H., Dikinis, S., Kjaer, D. W., Larsen, M. H., Achiam, M. P., Saarnio, J., Theodorou, D., Liakakos, T., Korkolis, D. P., Robb, W. B., Collins, C., Murphy, T., Reynolds, J., Tonini, Migliore, M., Bonavina, L., Valmasoni, M., Bardini, R., Weindelmayer, J., Terashima, M., White, R. E., Alghunaim, E., Elhadi, M., Leon-Takahashi, A. M., Medina-Franco, H., Lau, P. C., Okonta, K. E., Heisterkamp, J., Rosman, C., Beban, G., Babor, R., Gordon, A., Rossaak, J. I., Pal, K. M.I., Qureshi, A. U., Naqi, S. A., Syed, A. A., Barbosa, J., Vicente, C. S., Leite, J., Freire, J., Casaca, R., Costa, R. C.T., Scurtu, R. R., Mogoanta, S. S., Bolca, C., Constantinoiu, S., Sekhniaidze, D., Bjelović, M., So, J. B.Y., Gačevski, G., Loureiro, C., Pera, M., Bianchi, A., Moreno Gijón, M., Martín Fernández, J., Trugeda Carrera, M. S., Vallve-Bernal, M., Cítores Pascual, M. A., Elmahi, S., Halldestam, Hedberg, J., Mönig, S., Gutknecht, S., Tez, M., Guner, A., Tirnaksiz, M. B., Colak, E., Sevinç, B., Hindmarsh, A., Khan, Khoo, D., Byrom, R., Gokhale, J., Wilkerson, P., Jain, P., Chan, D., Robertson, K., Iftikhar, S., Skipworth, R., Forshaw, M., Higgs, S., Nijjar, R., Viswanath, Y. K.S., Turner, P., Dexter, S., Boddy, A., Allum, W. H., Oglesby, S., Cheong, E., Beardsmore, D., Maynard, N., Berrisford, R., Mercer, S., Puig, S., Melhado, R., Kelty, C., Underwood, T., Dawas, K., Lewis, W., Al-Bahrani, A., Bryce, G., Thomas, M., Arndt, A. T., Palazzo, F., Meguid, R. A., Collaborators, Fergusson, J., Beenen, E., Mosse, C., Salim, J., Cheah, S., Wright, T., Cerdeira, M. P., McQuillan, P., Richardson, M., Liem, H., Spillane, J., Yacob, M., Albadawi, F., Thorpe, T., Dingle, A., Cabalag, C., Loi, K., Fisher, O. M., Ward, S., Read, M., Johnson, M., Bassari, R., Bui, H., Cecconello, Raa, Sallum, Da Rocha, J. R.M., Lopes, L. R., Tercioti, V., Jds, Coelho, Ferrer, J. A.P., Buduhan, G., Tan, L., Srinathan, S., Shea, P., Yeung, J., Allison, F., Carroll, P., Vargas-Barato, F., Gonzalez, F., Ortega, J., Nino-Torres, L., Beltrán-García, T. C., Castilla, L., Pineda, M., Bastidas, A., Gómez-Mayorga, J., Cortés, N., Cetares, C., Caceres, S., Duarte, S., Pazdro, A., Snajdauf, M., Faltova, H., Sevcikova, M., Mortensen, P. B., Katballe, N., Ingemann, T., Kruhlikava, Morten B., Ainswort, A. P., Stilling, N. M., Eckardt, J., Holm, J., Thorsteinsson, M., Siemsen, M., Brandt, B., Nega, B., Teferra, E., Tizazu, A., Kauppila, J. H., Koivukangas, V., Meriläinen, S., Gruetzmann, R., Krautz, C., Weber, G., Golcher, H., Emons, G., Azizian, A., Ebeling, M., Niebisch, S., Kreuser, N., Albanese, G., Hesse, J., Volovnik, L., Boecher, U., Reeh, M., Triantafyllou, S., Schizas, D., Michalinos, A., Balli, E., Mpoura, M., Charalabopoulos, A., Manatakis, D. K., Balalis, D., Bolger, J., Baban, C., Mastrosimone, A., McAnena, O., Quinn, A., Ó Súilleabháin, C. B., Hennessy, M. M., Ivanovski, Khizer, H., Ravi, N., Donlon, N., Cervellera, M., Vaccari, S., Bianchini, S., Sartarelli, L., Asti, E., Bernardi, D., Merigliano, S., Provenzano, L., Scarpa, M., Saadeh, L., Salmaso, B., De Manzoni, G., Giacopuzzi, S., La Mendola, R., De Pasqual, C. A., Tsubosa, Y., Niihara, M., Irino, T., Makuuchi, R., Ishii, K., Mwachiro, M., Fekadu, A., Odera, A., Mwachiro, E., Alshehab, D., Ahmed, H. A., Shebani, A. O., Elhadi, A., Elnagar, F. A., Elnagar, H. F., Makkai-Popa, S. T., Wong, L. F., Tan, Y. R., Thannimalai, S., Ho, C. A., Pang, W. S., Tan, J. H., Hnl, Basave, Cortés-González, R., Lagarde, S. M., Van Lanschot, J. J.B., Cords, C., Jansen, W. A., Martijnse, I., Matthijsen, R., Bouwense, S., Klarenbeek, B., Verstegen, M., Van Workum, F., Ruurda, J. P., Van Der Sluis, P. C., De Maat, M., Evenett, N., Johnston, P., Patel, R., MacCormick, A., Young, M., Smith, B., Ekwunife, C., Memon, A. H., Shaikh, K., Wajid, A., Khalil, N., Haris, M., Mirza, Z. U., Sba, Qudus, Sarwar, M. Z., Shehzadi, A., Raza, A., Jhanzaib, M. H., Farmanali, J., Zakir, Z., Shakeel, O., Nasir, Khattak, S., Baig, M., Noor, M. A., Ahmed, H. H., Naeem, A., Pinho, A. C., Da Silva, R., Bernardes, A., Campos, J. C., Matos, H., Braga, T., Monteiro, C., Ramos, P., Cabral, F., Gomes, M. P., Martins, P. C., Correia, A. M., Videira, J. F., Ciuce, C., Drasovean, R., Apostu, R., Paitici, S., Racu, A. E., Obleaga, C. V., Beuran, M., Stoica, B., Negoita, Ciubotaru C., Cordos, Birla, R. D., Predescu, D., Hoara, P. A., Tomsa, R., Shneider, Agasiev, M., Ganjara, Gunjić, D., Veselinović, M., Babič, T., Chin, T. S., Shabbir, A., Kim, G., Crnjac, A., Samo, H., Díez Del Val, Del Val, Leturio, S., Ramón, J. M., Dal Cero, M., Rifá, S., Rico, M., Pagan Pomar, A., Martinez Corcoles, J. A., Rodicio Miravalles, J. L., Pais, S. A., Turienzo, S. A., Alvarez, L. S., Campos, P. V., Rendo, A. G., García, S. S., Epg, Santos, Martínez, E. T., Fernández Díaz, M. J., Magadán Álvarez, C., Martín, Concepción, Díaz López, C., Rosat Rodrigo, A., Pérez Sánchez, L. E., Bailón Cuadrado, M., Tinoco Carrasco, C., Choolani Bhojwani, E., Sánchez, D. P., Ahmed, M. E., Dzhendov, T., Lindberg, F., Rutegård, M., Sundbom, M., Mickael, C., Colucci, N., Schnider, A., Er, S., Kurnaz, E., Turkyilmaz, S., Turkyilmaz, A., Yildirim, R., Baki, B. E., Akkapulu, N., Karahan, O., Damburaci, N., Hardwick, R., Safranek, P., Sujendran, Bennett, J., Afzal, Z., Shrotri, M., Chan, B., Exarchou, K., Gilbert, T., Amalesh, T., Mukherjee, D., Mukherjee, S., Wiggins, T. H., Kennedy, R., McCain, S., Harris, A., Dobson, G., Davies, N., Wilson, I., Mayo, D., Bennett, D., Young, R., Manby, P., Blencowe, N., Schiller, M., Byrne, B., Mitton, D., Wong, V., Elshaer, A., Cowen, M., Menon, Tan, L. C., McLaughlin, E., Koshy, R., Sharp, C., Brewer, H., Das, N., Cox, M., Al Khyatt, W., Worku, D., Iqbal, R., Walls, L., McGregor, R., Fullarton, G., MacDonald, A., MacKay, C., Craig, C., Dwerryhouse, S., Hornby, S., Jaunoo, S., Wadley, M., Baker, C., Saad, M., Kelly, M., Davies, A., Di Maggio, F., Mistry, P., Singhal, R., Tucker, O., Kapoulas, S., Powell-Brett, S., Davis, P., Bromley, G., Watson, L., Verma, R., Ward, J., Shetty, V., Ball, C., Pursnani, K., Sarela, A., Sue Ling, H., Mehta, S., Hayden, J., To, N., Palser, T., Hunter, D., Supramaniam, K., Butt, Z., Ahmed, A., Kumar, S., Chaudry, A., Moussa, O., Kordzadeh, A., Wilson, M. Lorenzi B., Patil, P., Noaman, Willem, J., Bouras, G., Evans, R., Singh, M., Warrilow, H., Ahmad, A., Tewari, N., Yanni, F., Couch, J., Theophilidou, E., Reilly, J. J., Van Boxel, Gijs, Akbari, K., Zanotti, D., Sgromo, B., Sanders, G., Wheatley, T., Ariyarathenam, A., Reece-Smith, A., Humphreys, L., Choh, C., Carter, N., Knight, B., Pucher, P., Athanasiou, A., Tan, B., Abdulrahman, M., Vickers, J., Akhtar, K., Chaparala, R., Brown, R., Alasmar, M. M.A., Ackroyd, R., Patel, K., Tamhankar, A., Wyman, A., Walker, R., Grace, B., Abbassi, N., Slim, N., Ioannidi, L., Blackshaw, G., Havard, T., Escofet, X., Powell, A., Owera, A., Rashid, F., Jambulingam, P., Padickakudi, J., Ben-Younes, H., McCormack, K., Makey, I. A., Karush, M. K., Seder, C. W., Liptay, M. J., Chmielewski, G., Rosato, E. L., Berger, A. C., Zheng, R., Okolo, E., Singh, A., Scott, C. D., Weyant, M. J., and Mitchell, J. D.
Published: 2023

4. Postoperative outcomes in oesophagectomy with trainee involvement

Author: R P, T Evans, K Kamarajah, S, Bundred, J, Nepogodiev, D, Hodson, J, R van Hillegersberg, Gossage, J, Vohra, R, A Griffiths, E, Singh, P, Alderson, D, Jefferies, B, Mckay, S, Mohamed, I, K Siaw- Acheampong, Wanigasooriya, K, Whitehouse, T, Gjata, A, I Moreno, J, R Takeda, F, Kidane, B, R Guevara Castro, Harustiak, T, Bekele, A, Kechagias, A, Gockel, I, Kennedy, A, A Da Roit, Bagajevas, A, S Azagra, J, A Mahendran, H, Mej??a-Fern??ndez, L, B P, L Wijnhoven, J El Kafsi, H Sayyed, R, Sousa, M, S Sampaio, A, Negoi, I, Blanco, R, Wallner, B, M Schneider, P, K Hsu, P, Isik, A, Gananadha, S, Wills, V, Devadas, M, Duong, C, Talbot, M, W Hii, M, Jacobs, R, A Andreollo, N, Johnston, B, Darling, G, Isaza-Restrepo, A, Rosero, G, Arias-Am??zquita, F, Raptis, D, Gaedcke, J, Reim, D, Izbicki, J, H Egberts, J, Dikinis, S, W Kjaer, D, H Larsen, M, P Achiam, M, Saarnio, J, Theodorou, D, Liakakos, T, P Korkolis, D, B Robb, W, Collins, C, Murphy, T, Reynolds, J, Tonini, V, Migliore, M, Bonavina, L, Valmasoni, M, Bardini, R, Weindelmayer, J, Terashima, M, E White, R, Alghunaim, E, Elhadi, M, M Leon-Takahashi, A, Medina-Franco, H, C Lau, P, E Okonta, K, Heisterkamp, J, Rosman, C, Beban, G, Babor, R, Gordon, A, I Rossaak, J, K M, I Pal, U Qureshi, A, A Naqi, S, A Syed, A, Barbosa, J, S Vicente, C, Leite, J, Freire, J, Casaca, R, R C, T Costa, R Scurtu, R, S Mogoanta, S, Bolca, C, Constantinoiu, S, Sekhniaidze, D, Bjelovi??, M, J B, Y So, Ga??evski, G, Loureiro, C, Pera, M, Bianchi, A, M Moreno Gij??n, J Mart??n Fern??ndez, S Trugeda Carrera, M, Vallve-Bernal, M, A C??tores Pascual, M, Elmahi, S, Hedberg, J, M??nig, S, Gutknecht, S, Tez, M, Guner, A, B Tirnaksiz, T, Colak, E, Sevin??, B, Hindmarsh, A, Khan, I, Khoo, D, Byrom, R, Gokhale, J, Wilkerson, P, Jain, P, Chan, D, Robertson, K, Iftikhar, S, Skipworth, R, Forshaw, M, Higgs, S, Nijjar, R, Y K, S Viswanath, Turner, P, Dexter, S, Boddy, A, H Allum, W, Oglesby, S, Cheong, E, Beardsmore, D, Maynard, N, Berrisford, R, Mercer, S, Puig, S, Melhado, R, Kelty, C, Underwood, T, Dawas, K, Lewis, W, Al-Bahrani, A, Bryce, G, Thomas, M, T Arndt, A, Palazzo, F, A Meguid, R, Fergusson, J, Beenen, E, Mosse, C, Salim, J, Cheah, S, Wright, T, P Cerdeira, M, Mcquillan, P, Richardson, M, Liem, H, Spillane, J, Yacob, M, Albadawi, F, Thorpe, T, Dingle, A, Cabalag, C, Loi, K, M Fisher, O, Ward, S, Read, M, Johnson, M, Bassari, R, Bui, H, Cecconello, I, R A, A Sallum, J R, M da Rocha, R Lopes, L, Tercioti, V, J D, S Coelho, J A, P Ferrer, Buduhan, G, Tan, L, Srinathan, S, Shea, P, Yeung, J, Allison, F, Carroll, P, Vargas-Barato, F, Gonzalez, F, Ortega, J, Nino-Torres, L, C Beltr??n-Garc??a, T, Castilla, L, Pineda, M, Bastidas, A, G??mez-Mayorga, J, Cort??s, N, Cetares, C, Caceres, S, Duarte, S, Pazdro, A, Snajdauf, M, Faltova, H, Sevcikova, M, B Mortensen, P, Katballe, N, Ingemann, T, Morten, B, Kruhlikava, I, P Ainswort, A, M Stilling, N, Eckardt, J, Holm, J, Thorsteinsson, M, Siemsen, M, Brandt, B, Nega, B, Teferra, E, Tizazu, A, S Kauppila, J, Koivukangas, V, Meril??inen, S, Gruetzmann, R, Krautz, C, Weber, G, Golcher, H, Emons, G, Azizian, A, Ebeling, M, Niebisch, S, Kreuser, N, Albanese, G, Hesse, J, Volovnik, L, Boecher, U, Reeh, M, Triantafyllou, S, Schizas, D, Michalinos, A, Baili, E, Mpoura, M, Charalabopoulos, A, K Manatakis, D, Balalis, D, Bolger, J, Baban, C, Mastrosimone, A, Mcanena, O, Quinn, A, B ?? S??illeabh??in, C, M Hennessy, M, Ivanovski, I, Khizer, H, Ravi, N, Donlon, N, Cervellera, M, Vaccari, S, Bianchini, S, Sartarelli, L, Asti, E, Bernardi, D, Merigliano, S, Provenzano, L, Scarpa, M, Saadeh, L, Salmaso, B, DE MANZONI, Giovanni, Giacopuzzi, S, R La Mendola, A De Pasqual, C, Tsubosa, Y, Niihara, M, Irino, T, Makuuchi, R, Ishii, K, Mwachiro, M, Fekadu, A, Odera, A, Mwachiro, E, Alshehab, D, A Ahmed, H, O Shebani, A, Elhadi, A, A Elnagar, F, F Elnagar, H, T Makkai-Popa, S, F Wong, L, Yunrong, T, Thanninalai, S, C Aik, H, W Soon, P, J Huei, T, H N, L Basave, Cort??s-Gonz??lez, R, M Lagarde, S, J J, B van Lanschot, Cords, C, A Jansen, W, Martijnse, I, Matthijsen, R, Bouwense, S, Klarenbeek, B, Verstegen, M, F van Workum, P Ruurda, J, A van der Veen, W van den Berg, J, Evenett, N, Johnston, P, Patel, R, Maccormick, A, Young, M, Smith, B, Ekwunife, C, H Memon, A, Shaikh, K, Wajid, A, Khalil, N, Haris, M, U Mirza, Z, S B, A Qudus, Z Sarwar, M, Shehzadi, A, Raza, A, H Jhanzaib, M, Farmanali, J, Zakir, Z, Shakeel, O, Nasir, I, Khattak, S, Baig, M, A Noor, M, H Ahmed, H, Naeem, A, C Pinho, A, R da Silva, Matos, H, Braga, T, Monteiro, C, Ramos, P, Cabral, F, P Gomes, M, C Martins, P, M Correia, A, F Videira, J, Ciuce, C, Drasovean, R, Apostu, R, Paitici, S, E Racu, A, V Obleaga, C, Beuran, M, Stoica, B, Ciubotaru, C, Negoita, V, Cordos, I, D Birla, R, Predescu, D, A Hoara, P, Tomsa, R, Shneider, V, Agasiev, M, Ganjara, I, Gunji??, D, Veselinovi??, M, Babi??, T, S Chin, T, Shabbir, A, Kim, G, Crnjac, A, Samo, H, I D??ez del Val, Leturio, S, M Ram??n, J, M Dal Cero, Rif??, S, Rico, M, A Pagan Pomar, A Martinez Corcoles, J, L Rodicio Miravalles, J, A Pais, S, A Turienzo, S, S Alvarez, L, V Campos, P, G Rendo, A, S Garc??a, S, E P, G Santos, T Mart??nez, E, J Fern??ndez D??az, M, C Magad??n ??lvarez, V Concepci??n Mart??n, C D??az L??pez, A Rosat Rodrigo, E P??rez S??nchez, L, M Bail??n Cuadrado, C Tinoco Carrasco, E Choolani Bhojwani, P S??nchez, D, E Ahmed, M, Dzhendov, T, Lindberg, F, Ruteg??rd, M, Sundbom, M, Mickael, C, Colucci, N, Schnider, A, S, Er, Kurnaz, E, Turkyilmaz, S, Turkyilmaz, A, Yildirim, R, E Baki, B, Akkapulu, N, Karahan, O, Damburaci, N, Hardwick, R, Safranek, P, Sujendran, V, Bennett, J, Afzal, Z, Shrotri, M, Chan, B, Exarchou, K, Gilbert, T, Amalesh, T, Mukherjee, D, Mukherjee, S, H Wiggins, T, Kennedy, R, Mccain, S, Harris, A, Dobson, G, Davies, N, Wilson, I, Mayo, D, Bennett, D, Young, R, Manby, P, Blencowe, N, Schiller, M, Byrne, B, Mitton, D, Wong, V, Elshaer, A, Cowen, M, Menon, V, C Tan, L, Mclaughlin, E, Koshy, R, Sharp, C, Brewer, H, Das, N, Cox, M, W Al Khyatt, Worku, D, Iqbal, R, Walls, L, Mcgregor, R, Fullarton, G, Macdonald, A, Mackay, C, Craig, C, Dwerryhouse, S, Hornby, S, Jaunoo, S, Wadley, M, Baker, C, Saad, M, Kelly, M, Davies, A, F Di Maggio, Mistry, P, Singhal, R, Tucker, O, Kapoulas, S, Powell-Brett, S, Davis, P, Bromley, G, Watson, L, Verma, R, Ward, J, Shetty, V, Ball, C, Pursnani, K, Sarela, A, H Sue Ling, Mehta, S, Hayden, J, N, To, Palser, T, Hunter, D, Supramaniam, K, Butt, Z, Ahmed, A, Kumar, S, Chaudry, A, Moussa, O, Kordzadeh, A, Lorenzi, B, Wilson, M, Patil, P, Noaman, I, Willem, J, Bouras, G, Evans, R, Singh, M, Warrilow, H, Ahmad, A, Tewari, N, Yanni, F, Couch, J, Theophilidou, E, J Reilly, J, G van Boxel, Akbari, K, Zanotti, D, Sgromo, B, Sanders, G, Wheatley, T, Ariyarathenam, A, Reece-Smith, A, Humphreys, L, Choh, C, Carter, N, Knight, B, Pucher, P, Athanasiou, A, Tan, B, Abdulrahman, M, Vickers, J, Akhtar, K, Chaparala, R, Brown, R, M M, A Alasmar, Ackroyd, R, Patel, K, Tamhankar, A, Wyman, A, Walker, R, Grace, B, Abbassi, N, Slim, N, Ioannidi, L, Blackshaw, G, Havard, T, Escofet, X, Powell, A, Owera, A, Rashid, F, Jambulingam, P, Padickakudi, J, Ben-Younes, H, Mccormack, K, A Makey, I, K Karush, M, W Seder, C, J Liptay, M, Chmielewski, G, L Rosato, E, C Berger, A, Zheng, R, Okolo, E, Singh, A, D Scott, C, J Weyant, M, D Mitchell, J, Surgery, Evans, RPT, Hodson, J, Kamarajah, SK, Griffiths, EA, Singh, P, Alderson, D, Bundred, J, Gossage, J, Jefferies, B, McKay, S, Mohamed, I, Nepogodiev, D, Siaw-Acheampong, K, van Hillegersberg, R, Vohra, R, Wanigasooriya, K, Whitehouse, T, Gjata, A, Moreno, JI, Takeda, FR, Kidane, B, Castro, RG, Harustiak, T, Bekele, A, Kechagias, A, Gockel, I, Kennedy, A, Da Roit, A, Bagajevas, A, Azagra, JS, Mahendran, HA, Mejia-Fernandez, L, Wijnhoven, BPL, El Kafsi, J, Sayyed, RH, Sousa, M, Sampaio, AS, Negoi, I, Blanco, R, Wallner, B, Schneider, PM, Hsu, PK, Isik, A, Gananadha, S, Wills, V, Devadas, M, Duong, C, Talbot, M, Hii, MW, Jacobs, R, Andreollo, NA, Johnston, B, Darling, G, Isaza-Restrepo, A, Rosero, G, Arias-Amezquita, F, Raptis, D, Gaedcke, J, Reim, D, Izbicki, J, Egberts, JH, Dikinis, S, Kjaer, DW, Larsen, MH, Achiam, MP, Saarnio, J, Theodorou, D, Liakakos, T, Korkolis, DP, Robb, WB, Collins, C, Murphy, T, Reynolds, J, Tonini, V, Migliore, M, Bonavina, L, Valmasoni, M, Bardini, R, Weindelmayer, J, Terashima, M, White, RE, Alghunaim, E, Elhadi, M, Leon-Takahashi, AM, Medina-Franco, H, Lau, PC, Okonta, KE, Heisterkamp, J, Rosman, C, Beban, G, Babor, R, Gordon, A, Rossaak, JI, Pal, KMI, Qureshi, AU, Naqi, SA, Syed, AA, Barbosa, J, Vicente, CS, Leite, J, Freire, J, Casaca, R, Costa, RCT, Scurtu, RR, Mogoanta, SS, Bolca, C, Constantinoiu, S, Sekhniaidze, D, So, JBY, Gacvski, G, Loureiro, C, Pera, M, Bianchi, A, Gijon, MM, Fernandez, JM, Carrera, MST, Vallve-Bernal, M, Pascual, MAC, Elmahi, S, Halldestam, I, Hedberg, J, Monig, S, Gutknecht, S, Tez, M, Guner, A, Tirnaksiz, TB, Colak, E, Sevinc, B, Hindmarsh, A, Khan, I, Khoo, D, Byrom, R, Gokhale, J, Wilkerson, P, Jain, P, Chan, D, Robertson, K, Iftikhar, S, Skipworth, R, Forshaw, M, Higgs, S, Nijjar, R, Viswanath, YKS, Turner, P, Dexter, S, Boddy, A, Allum, WH, Oglesby, S, Cheong, E, Beardsmore, D, Maynard, N, Berrisford, R, Mercer, S, Puig, S, Melhado, R, Kelty, C, Underwood, T, Dawas, K, Lewis, W, Al-Bahrani, A, Bryce, G, Thomas, M, Arndt, AT, Palazzo, F, Meguid, RA, Fergusson, J, Beenen, E, Mosse, C, Salim, J, Cheah, S, Wright, T, Cerdeira, MP, McQuillan, P, Richardson, M, Liem, H, Spillane, J, Yacob, M, Albadawi, F, Thorpe, T, Dingle, A, Cabalag, C, Loi, K, Fisher, OM, Ward, S, Read, M, Johnson, M, Bassari, R, Bui, H, Cecconello, I, Sallum, RAA, da Rocha, JRM, Lopes, LR, Tercioti, V, Coelho, JDS, Ferrer, JAP, Buduhan, G, Tan, L, Srinathan, S, Shea, P, Yeung, J, Allison, F, Carroll, P, Vargas-Barato, F, Gonzalez, F, Ortega, J, Nino-Torres, L, Beltran-Garcia, TC, Castilla, L, Pineda, M, Bastidas, A, Gomez-Mayorga, J, Cortes, N, Cetares, C, Caceres, S, Duarte, S, Pazdro, A, Snajdauf, M, Faltova, H, Sevcikova, M, Mortensen, PB, Katballe, N, Ingemann, T, Morten, B, Kruhlikava, I, Ainswort, AP, Stilling, NM, Eckardt, J, Holm, J, Thorsteinsson, M, Siemsen, M, Brandt, B, Nega, B, Teferra, E, Tizazu, A, Kauppila, JS, Koivukangas, V, Merilainen, S, Gruetzmann, R, Krautz, C, Weber, G, Golcher, H, Emons, G, Azizian, A, Ebeling, M, Niebisch, S, Kreuser, N, Albanese, G, Hesse, J, Volovnik, L, Boecher, U, Reeh, M, Triantafyllou, S, Schizas, D, Michalinos, A, Baili, E, Mpoura, M, Charalabopoulos, A, Manatakis, DK, Balalis, D, Bolger, J, Baban, C, Mastrosimone, A, McAnena, O, Quinn, A, Suilleabhain, CBO, Hennessy, MM, Ivanovski, I, Khizer, H, Ravi, N, Donlon, N, Cervellera, M, Vaccari, S, Bianchini, S, Sartarelli, L, Asti, E, Bernardi, D, Merigliano, S, Provenzano, L, Scarpa, M, Saadeh, L, Salmaso, B, De Manzoni, G, Giacopuzzi, S, La Mendola, R, De Pasqual, CA, Tsubosa, Y, Niihara, M, Irino, T, Makuuchi, R, Ishii, K, Mwachiro, M, Fekadu, A, Odera, A, Mwachiro, E, AlShehab, D, Ahmed, HA, Shebani, AO, Elhadi, A, Elnagar, FA, Elnagar, HF, Makkai-Popa, ST, Wong, LF, Yunrong, T, Thanninalai, S, Aik, HC, Soon, PW, Huei, TJ, Basave, HNL, Cortes-Gonzalez, R, Lagarde, SM, van Lanschot, JJB, Cords, C, Jansen, WA, Martijnse, I, Matthijsen, R, Bouwense, S, Klarenbeek, B, Verstegen, M, van Workum, F, Ruurda, JP, van der Veen, A, van den Berg, JW, Evenett, N, Johnston, P, Patel, R, MacCormick, A, Young, M, Smith, B, Ekwunife, C, Memon, AH, Shaikh, K, Wajid, A, Khalil, N, Haris, M, Mirza, ZU, Qudus, SBA, Sarwar, MZ, Shehzadi, A, Raza, A, Jhanzaib, MH, Farmanali, J, Zakir, Z, Shakeel, O, Nasir, I, Khattak, S, Baig, M, Noor, MA, Ahmed, HH, Naeem, A, Pinho, AC, da Silva, R, Bernardes, A, Campos, JC, Matos, H, Braga, T, Monteiro, C, Ramos, P, Cabral, F, Gomes, MP, Martins, PC, Correia, AM, Videira, JF, Ciuce, C, Drasovean, R, Apostu, R, Paitici, S, Racu, AE, Obleaga, CV, Beuran, M, Stoica, B, Ciubotaru, C, Negoita, V, Cordos, I, Birla, RD, Predescu, D, Hoara, PA, Tomsa, R, Shneider, V, Agasiev, M, Ganjara, I, Gunjic, D, Veselinovic, M, Babic, T, Chin, TS, Shabbir, A, Kim, G, Crnjac, A, Samo, H, del Val, ID, Leturio, S, Ramon, JM, Dal Cero, M, Rifa, S, Rico, M, Pomar, AP, Corcoles, JAM, Miravalles, JLR, Pais, SA, Turienzo, SA, Alvarez, LS, Campos, PV, Rendo, AG, Garcia, SS, Santos, EPG, Martinez, ET, Diaz, MJF, Alvarez, CM, Martin, VC, Lopez, CD, Rodrigo, AR, Sanchez, LEP, Cuadrado, MB, Carrasco, CT, Bhojwani, EC, Sanchez, DP, Ahmed, ME, Dzhendov, T, Lindberg, F, Rutegard, M, Sundbom, M, Mickael, C, Colucci, N, Schnider, A, Er, S, Kurnaz, E, Turkyilmaz, S, Turkyilmaz, A, Yildirim, R, Baki, BE, Akkapulu, N, Karahan, O, Damburaci, N, Hardwick, R, Safranek, P, Sujendran, V, Bennett, J, Afzal, Z, Shrotri, M, Chan, B, Exarchou, K, Gilbert, T, Amalesh, T, Mukherjee, D, Mukherjee, S, Wiggins, TH, Kennedy, R, McCain, S, Harris, A, Dobson, G, Davies, N, Wilson, I, Mayo, D, Bennett, D, Young, R, Manby, P, Blencowe, N, Schiller, M, Byrne, B, Mitton, D, Wong, V, Elshaer, A, Cowen, M, Menon, V, Tan, LC, McLaughlin, E, Koshy, R, Sharp, C, Brewer, H, Das, N, Cox, M, Al Khyatt, W, Worku, D, Iqbal, R, Walls, L, McGregor, R, Fullarton, G, Macdonald, A, MacKay, C, Craig, C, Dwerryhouse, S, Hornby, S, Jaunoo, S, Wadley, M, Baker, C, Saad, M, Kelly, M, Davies, A, Di Maggio, F, Mistry, P, Singhal, R, Tucker, O, Kapoulas, S, Powell-Brett, S, Davis, P, Bromley, G, Watson, L, Verma, R, Ward, J, Shetty, V, Ball, C, Pursnani, K, Sarela, A, Ling, HS, Mehta, S, Hayden, J, To, N, Palser, T, Hunter, D, Supramaniam, K, Butt, Z, Ahmed, A, Kumar, S, Chaudry, A, Moussa, O, Kordzadeh, A, Patil, P, Noaman, I, Willem, J, Bouras, G, Evans, R, Singh, M, Warrilow, H, Ahmad, A, Tewari, N, Yanni, F, Couch, J, Theophilidou, E, Reilly, JJ, van Boxel, G, Akbari, K, Zanotti, D, Sgromo, B, Sanders, G, Wheatley, T, Ariyarathenam, A, Reece-Smith, A, Humphreys, L, Choh, C, Carter, N, Knight, B, Pucher, P, Athanasiou, A, Tan, B, Abdulrahman, M, Vickers, J, Akhtar, K, Chaparala, R, Brown, R, Alasmar, MMA, Ackroyd, R, Patel, K, Tamhankar, A, Wyman, A, Walker, R, Grace, B, Abbassi, N, Slim, N, Ioannidi, L, Blackshaw, G, Havard, T, Escofet, X, Powell, A, Owera, A, Rashid, F, Jambulingam, P, Padickakudi, J, Ben-Younes, H, McCormack, K, Makey, IA, Karush, MK, Seder, CW, Liptay, MJ, Chmielewski, G, Rosato, EL, Berger, AC, Zheng, R, Okolo, E, Singh, A, Scott, CD, Weyant, MJ, and Mitchell, JD
Subjects: squamous cell carcinoma, surgical mortality, AcademicSubjects/MED00910, Esophageal Neoplasms, SURGERY, IMPACT, clinical outcome, Anastomotic Leak, Adult, aged, anastomosis leakage, article, cancer staging, cardiovascular disease assessment, Charlson Comorbidity Index, cohort analysis, ECOG Performance Status, esophagectomy, esophagus cancer, female, follow up, histology, human, intensive care unit, length of stay, major clinical study, male, middle aged, mortality, necrosis, neoadjuvant chemoradiotherapy, neoadjuvant chemotherapy, observational study, postoperative complication, postoperative period, reoperation, surgical technique, Cohort Studies, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Surgical, Anastomosis, Surgical, General Medicine, Original Article, AcademicSubjects/MED00010, Life Sciences & Biomedicine, Anastomosis, SOCIETY, Bjs/5, trainee, oesophagectomy, trainee, Humans, Esophagectomy, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, RESIDENT INVOLVEMENT, Science & Technology, SURGICAL OUTCOMES
Abstract: Background The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusion Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery., The aim of this study was to determine the impact of trainee involvement in oesophagectomy on perioperative outcomes in the international multicentre Oesophago-Gastric Anastomosis Audit (OGAA). Analysis of 2232 oesophagectomies has shown that trainee involvement did not negatively impact perioperative outcomes.
Published: 2022

5. Textbook outcome following oesophagectomy for cancer: international cohort study

Author: Kamarajah, S. K., Evans, R. P. T., Nepogodiev, D., Hodson, J., Bundred, J. R., Gockel, I., Gossage, J. A., Isik, A., Kidane, B., Mahendran, H. A., Negoi, I., Okonta, K. E., Sayyed, R., van Hillegersberg, R., Vohra, R. S., Wijnhoven, B. P. L., Singh, P., Griffiths, E. A., Alderson, D., Bundred, J., Gossage, J., Jefferies, B., Mckay, S., Mohamed, I., Siaw-Acheampong, K., Vohra, R., Wanigasooriya, K., Whitehouse, T., Gjata, A., Moreno, J. I., Takeda, F. R., Guevara Castro, R., Harustiak, T., Bekele, A., Kechagias, A., Kennedy, A., Da Roit, A., Bagajevas, A., Azagra, J. S., Mej??a-Fern??ndez, L., El Kafsi, J., Sayyed, R. H., Sousa M, M., Sampaio, A. S., Blanco, R., Wallner, B., Schneider, P. M., Hsu, P. K., Gananadha, S., Wills, V., Devadas, M., Duong, C., Talbot, M., Hii, M. W., Jacobs, R., Andreollo, N. A., Johnston, B., Darling, G., Isaza-Restrepo, A., Rosero, G., Arias-Am??zquita, F., Raptis, D., Gaedcke, J., Reim, D., Izbicki, J., Egberts, J. H., Dikinis, S., Kjaer, D. W., Larsen, M. H., Achiam, M. P., Saarnio, J., Theodorou, D., Liakakos, T., Korkolis, D. P., Robb, W. B., Collins, C., Murphy, T., Reynolds, J., Tonini, V., Migliore, M., Bonavina, L., Valmasoni, M., Bardini, R., Weindelmayer, J., Terashima, M., White, R. E., Alghunaim, E., Elhadi, M., Leon-Takahashi, A. M., Medina-Franco, H., Lau, P. C., Heisterkamp, J., Rosman, C., Beban, G., Babor, R., Gordon, A., Rossaak, J. I., Pal, K. M. I., Qureshi, A. U., Naqi, S. A., Syed, A. A., Barbosa, J., Vicente, C. S., Leite, J., Freire, J., Casaca, R., Costa, R. C. T., Scurtu, R. R., Mogoanta, S. S., Bolca, C., Constantinoiu, S., Sekhniaidze, D., Bjelovi??, M., J. B. Y., So, Ga??evski, G., Loureiro, C., Pera, M., Bianchi, A., Moreno Gij??n, M., Fern??ndez, J. Mart??n., Trugeda Carrera, M. S., Vallve-Bernal, M., C??tores Pascual, M. A., Elmahi, S., Halldestam, I., Hedberg, J., M??nig, S., Gutknecht, S., Tez, M., Guner, A., Tirnaksiz, M. B., Colak, E., Sevin??, B., Hindmarsh, A., Khan, I., Khoo, D., Byrom, R., Gokhale, J., Wilkerson, P., Jain, P., Chan, D., Robertson, K., Iftikhar, S., Skipworth, R., Forshaw, M., Higgs, S., Nijjar, R., Viswanath, Y. K. S., Turner, P., Dexter, S., Boddy, A., Allum, W. H., Oglesby, S., Cheong, E., Beardsmore, D., Maynard, N., Berrisford, R., Mercer, S., Puig, S., Melhado, R., Kelty, C., Underwood, T., Dawas, K., Lewis, W., Bryce, G., Thomas, M., Arndt, A. T., Palazzo, F., Meguid, R. A., Fergusson, J., Beenen, E., Mosse, C., Salim, J., Cheah, S., Wright, T., Cerdeira, M. P., Mcquillan, P., Richardson, M., Liem, H., Spillane, J., Yacob, M., Albadawi, F., Thorpe, T., Dingle, A., Cabalag, C., Loi, K., Fisher, O. M., Ward, S., Read, M., Johnson, M., Bassari, R., Bui, H., Cecconello, I., Sallum, R. A. A., da Rocha, J. R. M., Lopes, L. R., Tercioti Jr, V., Coelho, J. D. S., Ferrer, J. A. P., Buduhan, G., Tan, L., Srinathan, S., Shea, P., Yeung, J., Allison, F., Carroll, P., Vargas-Barato, F., Gonzalez, F., Ortega, J., Nino-Torres, L., Beltr??n-Garc??a, T. C., Castilla, L., Pineda, M., Bastidas, A., G??mez-Mayorga, J., Cort??s, N., Cetares, C., Caceres, S., Duarte, S., Pazdro, A., Snajdauf, M., Faltova, H., Sevcikova, M., Mortensen, P. B., Katballe, N., Ingemann, T., Morten, B., Kruhlikava, I., Ainswort, A. P., Stilling, N. M., Eckardt, J., Holm, J., Thorsteinsson, M., Siemsen, M., Brandt, B., Nega, B., Teferra, E., Tizazu, A., Kauppila, J. H., Koivukangas, V., Meril??inen, S., Gruetzmann, R., Krautz, C., Weber, G., Golcher, H., Emons, G., Azizian, A., Ebeling, M., Niebisch, S., Kreuser, N., Albanese, G., Hesse, J., Volovnik, L., Boecher, U., Reeh, M., Triantafyllou, S., Schizas, D., Michalinos, A., Balli, E., Mpoura, M., Charalabopoulos, A., Manatakis, D. K., Balalis, D., Bolger, J., Baban, C., Mastrosimone, A., Mcanena, O., Quinn, A., S??illeabh??in, C. B., Hennessy, M. M., Ivanovski, I., Khizer, H., Ravi, N., Donlon, N., Cervellera, M., Vaccari, S., Bianchini, S., Asti, E., Bernardi, D., Merigliano, S., Provenzano, L., Scarpa, M., Saadeh, L., Salmaso, B., De Manzoni, G., Giacopuzzi, S., La Mendola, R., De Pasqual, C. A., Tsubosa, Y., Niihara, M., Irino, T., Makuuchi, R., Ishii K, K., Mwachiro, M., Fekadu, A., Odera, A., Mwachiro, E., Alshehab, D., Ahmed, H. A., Shebani, A. O., Elhadi, A., Elnagar, F. A., Elnagar, H. F., Makkai-Popa, S. T., Wong, L. F., Tan, Y. R., Thannimalai, S., C. A., Ho, Pang, W. S., Tan, J. H., Basave, H. N. L., Cort??s-Gonz??lez, R., Lagarde, S. M., van Lanschot, J. J. B., Cords, C., Jansen, W. A., Martijnse, I., Matthijsen, R., Bouwense, S., Klarenbeek, B., Verstegen, M., van Workum, F., Ruurda, J. P., van der Sluis, P. C., de Maat, M., Evenett, N., Johnston, P., Patel, R., Maccormick, A., Smith, B., Ekwunife, C., Memon, A. H., Shaikh, K., Wajid, A., Khalil, N., Haris, M., Mirza, Z. U., Qudus, S. B. A., Sarwar, M. Z., Shehzadi, A., Raza, A., Jhanzaib, M. H., Farmanali, J., Zakir, Z., Shakeel, O., Nasir, I., Khattak, S., Baig, M., Noor, M. A., Ahmed, H. H., Naeem, A., Pinho, A. C., da Silva, R., Bernardes, A., Campos, J. C., Matos, H., Braga, T., Monteiro, C., Ramos, P., Cabral, F., Gomes, M. P., Martins, P. C., Correia, A. M., Videira, J. F., Ciuce, C., Drasovean, R., Apostu, R., Paitici, S., Racu, A. E., Obleaga, C. V., Beuran, M., Stoica, B., Ciubotaru, C., Negoita, V., Cordos, I., Birla, R. D., Predescu, D., Hoara, P. A., Tomsa, R., Shneider, V., Agasiev, M., Ganjara, I., Gunji??, D., Veselinovi??, M., Babi??, T., Chin, T. S., Shabbir, A., Kim, G., Crnjac, A., Samo, H., D??ez del Val, I., Leturio, S., Ram??n, J. M., Dal Cero, M., Rif??, S., Rico, M., Pagan Pomar, A., Martinez Corcoles, J. A., Rodicio Miravalles, J. L., Pais, S. A., Turienzo, S. A., Alvarez, L. S., Campos, P. V., Rendo, A. G., Garc??a, S. S., Santos, E. P. G., Mart??nez, E. T., Fern??ndez D??az, M. J., lvarez, C. Magad??n., Mart??n, V. Concepci??n., D??az L??pez, C., Rosat Rodrigo, A., P??rez S??nchez, L. E., Cuadrado, M. Bail??n., Tinoco Carrasco, C., Choolani Bhojwani, E., S??nchez, D. P., Ahmed, M. E., Dzhendov, T., Lindberg, F., Ruteg??rd, M., Sundbom, M., Mickael, C., Colucci, N., Schnider, A., Er, S., Kurnaz, E., Turkyilmaz, S., Turkyilmaz, A., Yildirim, R., Baki, B. E., Akkapulu, N., Karahan, O., Damburaci, N., Hardwick, R., Safranek, P., Sujendran, V., Bennett, J., Afzal, Z., Shrotri, M., Chan, B., Exarchou, K., Gilbert, T., Amalesh, T., Mukherjee, D., Mukherjee, S., Wiggins, T. H., Kennedy, R., Mccain, S., Harris, A., Dobson, G., Davies, N., Wilson, I., Mayo, D., Bennett, D., Young, R., Manby, P., Blencowe, N., Schiller, M., Byrne, B., Mitton, D., Wong, V., Elshaer, A., Cowen, M., Menon, V., Tan, L. C., Mclaughlin, E., Koshy, R., Sharp, C., Brewer, H., Das, N., Cox, M., Al Khyatt, W., Worku, D., Iqbal, R., Walls, L., Mcgregor, R., Fullarton, G., Macdonald, A., Mackay, C., Craig, C., Dwerryhouse, S., Hornby, S., Jaunoo, S., Wadley, M., Baker, C., Saad, M., Kelly, M., Davies, A., Di Maggio, F., Mistry, P., Singhal, R., Tucker, O., Kapoulas, S., Powell-Brett, S., Davis, P., Bromley, G., Watson, L., Verma, R., Ward, J., Shetty, V., Ball, C., Pursnani, K., Sarela, A., Sue Ling, H., Mehta, S., Hayden, J., To, N., Palser, T., Hunter, D., Supramaniam, K., Butt, Z., Ahmed, A., Kumar, S., Chaudry, A., Moussa, O., Kordzadeh, A., Lorenzi, B., Wilson, M., Patil, P., Noaman, I., Bouras, G., Evans, R., Singh, M., Warrilow, H., Ahmad, A., Tewari, N., Yanni, F., Couch, J., Theophilidou, E., Reilly, J. J., van Boxel, G., Akbari, K., Zanotti, D., Sanders, G., Wheatley, T., Ariyarathenam, A., Reece-Smith, A., Humphreys, L., Choh, C., Carter, N., Knight, B., Pucher, P., Athanasiou, A., Tan, B., Abdulrahman, M., Vickers, J., Akhtar, K., Chaparala, R., Brown, R., Alasmar, M. M. A., Ackroyd, R., Patel, K., Tamhankar, A., Wyman, A., Walker, R., Grace, B., Abbassi, N., Slim, N., Ioannidi, L., Blackshaw, G., Havard, T., Escofet, X., Powell, A., Owera, A., Rashid, F., Jambulingam, P., Padickakudi, J., Ben-Younes, H., Mccormack, K., Makey, I. A., Karush, M. K., Seder, C. W., Liptay, M. J., Chmielewski, G., Rosato, E. L., Berger, A. C., Zheng, R., Okolo, E., Singh, A., Scott, C. D., Weyant, M. J., Mitchell, J. D., and Surgery
Subjects: Male, Textbook, MINIMALLY INVASIVE ESOPHAGECTOMY, Minimally Invasive Surgical Procedures/methods, Esophageal Neoplasms, SURGERY, Anastomosis, LYMPH-NODE RETRIEVAL, Anastomosis, Surgical, education, Anastomosis, Surgical/adverse effects, Esophageal Neoplasms/pathology, Esophagectomy/methods, Cohort Studies, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Treatment Outcome, SDG 3 - Good Health and Well-being, Humans, Minimally Invasive Surgical Procedures, Esophagectomy, Surgical, esophagectomy, Surgery, Textbook, esophagectomy, esophageal cancer, esophageal cancer
Abstract: Background Textbook outcome has been proposed as a tool for the assessment of oncological surgical care. However, an international assessment in patients undergoing oesophagectomy for oesophageal cancer has not been reported. This study aimed to assess textbook outcome in an international setting. Methods Patients undergoing curative resection for oesophageal cancer were identified from the international Oesophagogastric Anastomosis Audit (OGAA) from April 2018 to December 2018. Textbook outcome was defined as the percentage of patients who underwent a complete tumour resection with at least 15 lymph nodes in the resected specimen and an uneventful postoperative course, without hospital readmission. A multivariable binary logistic regression model was used to identify factors independently associated with textbook outcome, and results are presented as odds ratio (OR) and 95 per cent confidence intervals (95 per cent c.i.). Results Of 2159 patients with oesophageal cancer, 39.7 per cent achieved a textbook outcome. The outcome parameter ‘no major postoperative complication’ had the greatest negative impact on a textbook outcome for patients with oesophageal cancer, compared to other textbook outcome parameters. Multivariable analysis identified male gender and increasing Charlson comorbidity index with a significantly lower likelihood of textbook outcome. Presence of 24-hour on-call rota for oesophageal surgeons (OR 2.05, 95 per cent c.i. 1.30 to 3.22; P = 0.002) and radiology (OR 1.54, 95 per cent c.i. 1.05 to 2.24; P = 0.027), total minimally invasive oesophagectomies (OR 1.63, 95 per cent c.i. 1.27 to 2.08; P < 0.001), and chest anastomosis above azygous (OR 2.17, 95 per cent c.i. 1.58 to 2.98; P < 0.001) were independently associated with a significantly increased likelihood of textbook outcome. Conclusion Textbook outcome is achieved in less than 40 per cent of patients having oesophagectomy for cancer. Improvements in centralization, hospital resources, access to minimal access surgery, and adoption of newer techniques for improving lymph node yield could improve textbook outcome.
Published: 2022

6. Core Outcome Set for Surgical Trials in Gastric Cancer (GASTROS Study):International patient and healthcare professional consensus

Author: Alkhaffaf, B, Metryka, A, Blazeby, J M, Glenny, A-M, Adeyeye, A, Costa, P M, Diez Del Val, I, Gisbertz, S S, Guner, A, Law, S, Lee, H-J, Li, Z, Nakada, K, Reim, D, Vorwald, P, Baiocchi, G L, Allum, W, Chaudry, M A, Griffiths, E A, Williamson, P R, Bruce, I A, Li, S., He, Yl, Xu, Z., Xue, Y., Liang, H., Li, G., Zhao, E., Neumann, P., O’Neill, L., Guinan, E., Zanotti, D., de Manzoni, G., Hagens, Erc., van Berge Henegouwen, Mi., Lages, P., Onofre, S., Restrepo Nunez, Rm., Salcedo Cabanas, G., Posada Gonzalez, M., Marin Campos, C., Candas, B., Emre Baki, B., Selim Bodur, M., Yildirim, R., Burak Cekic, A., Brown, J., Hayes, K., Daher, I., Gianchandani Moorjani, Rh., Adetoyese Adeyeye, A., Sulaiman Olayide, A., Mitsuo Leon-Takahashi, A., Pueyo Rabanal, A., Peri, A., Boddy, A., Novotny, A., Charalabopoulos, A., Alemdar, A., Souadka, A., Rodrigues Gomes, Am., Lazaro, A., Maciel Da Silva, A., do Rosario da Conceicao Silva e Santos, A., Guidi, A., Silva Bernardes, Aj., Quinn, A., Isik, A., A Slipek, A., Candas Altinbas, B., Johnson Alegbeleye, B., Wool Eom, B., Frittoli, B., Lonsdale, B., Rogers, B., Ammori, Bj., Rau, B., Molteni, B., Byrne, Be., Villacıs- Bermeo, Ba., Villacıs Gallardo, Be., Kose, B., Sampedro Nogueira, Cj., Loureiro, C., Oliveira de Sousa, Cm., Collins, Cg., Nonso Ekwunife, C., Chukwunwendu Osuagwu, C., Wong, Cly., Winkler, C., Reim, D., Kjær, Dw., Cooper, D., Horner, D., Irvine, D., Bowrey, Dj., Chuter, Dj., Elliot, D., Mcghee, D., Toth, D., Ofner, D., Manatakis, Dk., Silveira Martins, Dr., Belt, Ejt., Cattaneo, E., Samadov, E., Colak, E., Treppiedi, E., Guglielmi, E., Redondo- Villahoz, E., Ciferri, E., Tiemens-de Graaf, E., Cocozza, E., Pape, E., Drozdov, Es., Enrico, F., Rashid, F., Sandri, Marco, Rosa, F., Mingol Navarro, F., Simionato Perrotta, F., Chan, Fsy., Saavedra Tomasich, Fd., Takeda, Fr., Farrell, F., Olanike Wuraola, F., Rosero, G., Bevilacqua, G., Baronio, G., Mura, G., D’Eugenio, G., Ortega-Perez, G., Tilt, G., Sutcliffe, G., Mureddu, G., Guerra Jacob, G., Daneri, H., Olufemi Gbenga, H., Okabe, H., Kingsford Smith, I., Olawale Lateef, I., Garosio, I., Hatipoglu, I., Gockel, I., Negoi, I., Min, Ish., Mesquita, Imm., Diez del Val, I., Leemhuis, Jhf., Gossage, Ja., Weindelmayer, J., Izbicki, Jr., McKenzie Manson, J., Kelly, J., Stoot, Jhmb., Haveman, Jw., Brown, Jd., Sultan, J., Hassall, J., van Sandick, J., Saunders, Jh., Clarke, Jk., Heisterkamp, J., Vargas, Ji., Couselo Villanueva, Jm., Ingmire, J., Mcewen, J., Galindo Alvarez, J., Turner, J., Peng, J., Roberts, K., Brandon, Kg., Mitchell, K., Mccarthy, K., Akhtar, K., Mikhailovich, Kn., Corbelli, L., Medeiros Milhomem, L., Solaini, L., Fengyuan, L., Xinchun, L., Timmermans, L., Porritt, L., Taglietti, L., Bonavina, L., F. Pinheiro L., de los Angeles Mayo Ossorio, M., Schiavo, M., Marchesiello, M., das Dores Vieira Leite, M., Demois, M., Di Felice, Mt., de Sousa, Md., Takahashi, M., Forshaw, M., Berselli, M., Paro, M., Usta, Ma., Yan, Mh., Pinchin, M., Caprioli, M., Rubbini, M., Cowen, M., Herrera Servin, Ma., Li, Mz., Sasako, M., Shukri Jahit, M., Ngonyoku Muhinga, M., Tareen, Ma., Ahmad, Mf., Bodur, Ms., Kaban, M., Farooq, N., Coburn, N., Cooper, N., Blencowe, Ns., Loria, N., de Vries, N., Adami Andreollo, N., Koksal, N., Zanini, N., Kreuser, N., Okkabaz, N., Damiana, O., Afuwape, O., Kayode Fasiku, O., Comensoli, O., F. Koroye O., Capener, P., Morgagni, P., Pernadas Lages, Pm., Wilkerson, Pm., Turner, P., Dutton, P., Hayes, P., Vorwald, P., Singh, P., Gan, Q., Kottayasamy Seenivasagam, R., Ayloor Seshadri, R., Guevara Castro, R., Douglas, R., Koshy, Rm., Yıldırım, R., Skipworth, Rje., Gould, Ra., Wetherill, Rc., Shaw, R., Burley, Ra., Palatucci, R., Racalbuto, R., Correia Casaca, Rm., Lagarde, Sm., Gana, S., Marietti, S., Qureshi, S., Morales-Conde, S., Molfino, S., Barreto, Sg., Turkyilmaz, S., Turan-Trabzon, S., Frisch, S., Castoldi, S., Belloni, S., Flisi, S., Galloway, S., Maria, Sr., Royston, S., Boyle, T., Sezer, T., Mengardo, V., Concepcion Martın, V., Lee Wills, V., Owen-Holt, V., Casagrande, V., Al-Khyatt, W., Jansen, W., Wang, W., Eshuis, W., Polkowski, Wp., Huang, X., Wang, X., Chen, Xz., Gonzalez Dominguez, Y., Wang, Y., Viswanath, Yks., He, Yl., Demir, Z., Na, Z., Surgery, CCA - Cancer Treatment and Quality of Life, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Imaging and biomarkers, Experimental Immunology, Clinical Immunology and Rheumatology, CCA -Cancer Center Amsterdam, and CCA - Cancer Treatment and quality of life
Subjects: medicine.medical_specialty, Manchester Cancer Research Centre, business.industry, gastric cancer, ResearchInstitutes_Networks_Beacons/mcrc, Delphi method, MEDLINE, Cancer, medicine.disease, Outcome (game theory), 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), 030220 oncology & carcinogenesis, Family medicine, gastros, Medicine, Surgery, 030212 general & internal medicine, Stage (cooking), Adverse effect, business, Set (psychology)
Abstract: Background Surgery is the primary treatment that can offer potential cure for gastric cancer, but is associated with significant risks. Identifying optimal surgical approaches should be based on comparing outcomes from well designed trials. Currently, trials report different outcomes, making synthesis of evidence difficult. To address this, the aim of this study was to develop a core outcome set (COS)—a standardized group of outcomes important to key international stakeholders—that should be reported by future trials in this field. Methods Stage 1 of the study involved identifying potentially important outcomes from previous trials and a series of patient interviews. Stage 2 involved patients and healthcare professionals prioritizing outcomes using a multilanguage international Delphi survey that informed an international consensus meeting at which the COS was finalized. Results Some 498 outcomes were identified from previously reported trials and patient interviews, and rationalized into 56 items presented in the Delphi survey. A total of 952 patients, surgeons, and nurses enrolled in round 1 of the survey, and 662 (70 per cent) completed round 2. Following the consensus meeting, eight outcomes were included in the COS: disease-free survival, disease-specific survival, surgery-related death, recurrence, completeness of tumour removal, overall quality of life, nutritional effects, and ‘serious’ adverse events. Conclusion A COS for surgical trials in gastric cancer has been developed with international patients and healthcare professionals. This is a minimum set of outcomes that is recommended to be used in all future trials in this field to improve trial design and synthesis of evidence.
Published: 2021

7. Mortality from esophagectomy for esophageal cancer across low, middle, and high-income countries: An international cohort study

Author: Kamarajah, S. K. Nepogodiev, D. Bekele, A. Cecconello, I. and Evans, R. P. T. Guner, A. Gossage, J. A. Harustiak, T. and Hodson, J. Isik, A. Kidane, B. Leon-Takahashi, A. M. and Mahendran, H. A. Negoi, I. Okonta, K. E. Rosero, G. and Sayyed, R. H. Singh, P. Takeda, F. R. van Hillegersberg, R. and Vohra, R. S. White, R. E. Griffiths, E. A. Alderson, D. and Bundred, J. Evans, R. P. T. Gossage, J. Griffiths, E. A. and Jefferies, B. Kamarajah, S. K. McKay, S. Mohamed, I. and Nepogodiev, D. Siaw-Acheampong, K. Singh, P. van Hillegersberg, R. Vohra, R. Wanigasooriya, K. Whitehouse, T. and Gjata, A. Moreno, J. I. Takeda, F. R. Kidane, B. and Guevara, Castro R. Harustiak, T. Bekele, A. Kechagias, A. and Gockel, I. Kennedy, A. Da Roit, A. Bagajevas, A. and Azagra, J. S. Mahendran, H. A. Mejia-Fernandez, L. and Wijnhoven, B. P. L. El Kafsi, J. Sayyed, R. H. Sousa, M. and Sampaio, A. S. Negoi, I. Blanco, R. Wallner, B. and Schneider, P. M. Hsu, P. K. Isik, A. Gananadha, S. and Wills, V. Devadas, M. Duong, C. Talbot, M. Hii, M. W. and Jacobs, R. Andreollo, N. A. Johnston, B. Darling, G. and Isaza-Restrepo, A. Rosero, G. Arias-Amezquita, F. Raptis, D. and Gaedcke, J. Reim, D. Izbicki, J. Egberts, J. H. and Dikinis, S. Kjaer, D. W. Larsen, M. H. Achiam, M. P. and Saarnio, J. Theodorou, D. Liakakos, T. Korkolis, D. P. and Robb, W. B. Collins, C. Murphy, T. Reynolds, J. Tonini, V. Migliore, M. Bonavina, L. Valmasoni, M. Bardini, R. and Weindelmayer, J. Terashima, M. White, R. E. Alghunaim, E. Elhadi, M. Leon-Takahashi, A. M. Medina-Franco, H. and Lau, P. C. Okonta, K. E. Heisterkamp, J. Rosman, C. van Hillegersberg, R. Beban, G. Babor, R. Gordon, A. and Rossaak, J. I. Pal, K. M. I. Qureshi, A. U. Naqi, S. A. and Syed, A. A. Barbosa, J. Vicente, C. S. Leite, J. Freire, J. Casaca, R. Costa, R. C. T. Scurtu, R. R. Mogoanta, S. S. Bolca, C. Constantinoiu, S. Sekhniaidze, D. Bjelovic, M. So, J. B. Y. Gacevski, G. Loureiro, C. Pera, M. and Bianchi, A. Moreno, Gijon M. Martin Fernandez, J. Carrera, M. S. Trugeda Vallve-Bernal, M. Pascual, M. A. Citores and Elmahi, S. Halldestam, I. Hedberg, J. Monig, S. and Gutknecht, S. Tez, M. Guner, A. Tirnaksiz, M. B. Colak, E. Sevinc, B. Hindmarsh, A. Khan, I. Khoo, D. Byrom, R. Gokhale, J. Wilkerson, P. Jain, P. Chan, D. and Robertson, K. Iftikhar, S. Skipworth, R. Forshaw, M. and Higgs, S. Gossage, J. Nijjar, R. Viswanath, Y. K. S. and Turner, P. Dexter, S. Boddy, A. Allum, W. H. Oglesby, S. and Cheong, E. Beardsmore, D. Vohra, R. Maynard, N. and Berrisford, R. Mercer, S. Puigt, S. Melhadot, R. Kelty, C. Underwood, T. Dawas, K. Lewis, W. Al-Bahrani, A. and Bryce, G. Thomas, M. Arndt, A. T. Palazzo, F. Meguid, R. A. Fergusson, J. Beenen, E. Mosse, C. Salim, J. and Cheah, S. Wright, T. Cerdeira, M. P. McQuillan, P. and Richardson, M. Liem, H. Spillane, J. Yacob, M. Albadawi, F. Thorpe, T. Dingle, A. Cabalag, C. Loi, K. Fisher, O. M. Ward, S. Read, M. Johnson, M. Bassari, R. Bui, H. Cecconello, I. Sallum, R. A. A. da Rocha, J. R. M. and Lopes, L. R. Tercioti, Jr., V. Coelho, J. D. Ferrer, J. A. P. Buduhan, G. Tan, L. Srinathan, S. Shea, P. Yeung, J. Allison, F. Carroll, P. Vargas-Barato, F. Gonzalez, F. Ortega, J. Nino-Torres, L. Beltran-Garcia, T. C. and Castilla, L. Pineda, M. Bastidas, A. Gomez-Mayorga, J. and Cortes, N. Cetares, C. Caceres, S. Duarte, S. Pazdro, A. and Snajdauf, M. Faltova, H. Sevcikova, M. Mortensen, P. B. and Katballe, N. Ingemann, T. Morten, B. Kruhlikava, I. and Ainswort, A. P. Stilling, N. M. Eckardt, J. Holm, J. and Thorsteinsson, M. Siemsen, M. Brandt, B. Nega, B. and Teferra, E. Tizazu, A. Kauppila, J. H. Koivukangas, V. and Merilainen, S. Gruetzmann, R. Krautz, C. Weber, G. and Golcher, H. Emons, G. Azizian, A. Ebeling, M. Niebisch, S. Kreuser, N. Albanese, G. Hesse, J. Volovnik, L. and Boecher, U. Reeh, M. Triantafyllou, S. Schizas, D. and Michalinos, A. Mpali, E. Mpoura, M. Charalabopoulos, A. and Manatakis, D. K. Balalis, D. Bolger, J. Baban, C. and Mastrosimone, A. McAnena, O. Quinn, A. Suilleabhain, C. B. O. Hennessy, M. M. Ivanovski, I. Khizer, H. Ravi, N. and Donlon, N. Cervellera, M. Vaccari, S. Bianchini, S. and Sartarelli, L. Asti, E. Bernardi, D. Merigliano, S. and Provenzano, L. Scarpa, M. Saadeh, L. Salmaso, B. De Manzoni, G. Giacopuzzi, S. La Mendola, R. De Pasqual, C. A. and Tsubosa, Y. Niihara, M. Irino, T. Makuuchi, R. and Ishii, K. Mwachiro, M. Fekadu, A. Odera, A. Mwachiro, E. and AlShehab, D. Ahmed, H. A. Shebani, A. O. Elhadi, A. and Elnagar, F. A. Elnagar, H. F. Makkai-Popa, S. T. Wong, L. F. and Tan, Y. R. Thannimalai, S. Ho, C. A. Pang, W. S. and Tan, J. H. Basave, H. N. L. Cortes-Gonzalez, R. Lagarde, S. M. van Lanschot, J. J. B. Cords, C. Jansen, W. A. and Martijnse, I. Matthijsen, R. Bouwense, S. Klarenbeek, B. and Verstegen, M. van Workum, F. Ruurda, J. P. van der Sluis, P. C. de Maat, M. Evenett, N. Johnston, P. Patel, R. and MacCormick, A. Young, M. Smith, B. Ekwunife, C. Memon, A. H. Shaikh, K. Wajid, A. Khalil, N. Haris, M. and Mirza, Z. U. Qudus, S. B. A. Sarwar, M. Z. Shehzadi, A. and Raza, A. Jhanzaib, M. H. Farmanali, J. Zakir, Z. and Shakeel, O. Nasir, I. Khattak, S. Baig, M. Noor, M. A. and Ahmed, H. H. Naeem, A. Pinho, A. C. da Silva, R. and Bernardes, A. Campos, J. C. Matos, H. Braga, T. and Monteiro, C. Ramos, P. Cabral, F. Gomes, M. P. Martins, P. C. Correia, A. M. Videira, J. F. Ciuce, C. Drasovean, R. Apostu, R. Ciuce, C. Paitici, S. Racu, A. E. and Obleaga, C. V. Beuran, M. Stoica, B. Ciubotaru, C. and Negoita, V. Cordos, I. Birla, R. D. Predescu, D. Hoara, P. A. Tomsa, R. Shneider, V. Agasiev, M. Ganjara, I. and Gunjic, D. Veselinovic, M. Babic, T. Chin, T. S. and Shabbir, A. Kim, G. Crnjac, A. Samo, H. Del Val, I. Diez and Leturio, S. Ramon, J. M. Dal Cero, M. Rifa, S. Rico, M. Pomar, A. Pagan Corcoles, J. A. Martinez Miravalles, J. L. Rodicio Pais, S. A. Turienzo, S. A. Alvarezt, L. S. and Alvarez, L. S. Campos, P. V. Rendo, A. G. Garcia, S. S. and Santos, E. P. G. Martinez, E. T. Fernandez, Diaz Mj Magadan, Alvarez C. Concepcion, Martin V. Diaz, Lopez C. Rosat, Rodrigo A. Perez, Sanchez L. E. Bailon, Cuadrado M. Tinoco, Carrasco C. Bhojwani, E. Choolani Sanchez, D. P. Ahmed, M. E. Dzhendov, T. Lindberg, F. Rutegard, M. Sundbom, M. and Mickael, C. Colucci, N. Schnider, A. Er, S. Kurnaz, E. Turkyilmaz, S. Turkyilmaz, A. Yildirim, R. Baki, B. E. Akkapulu, N. Karahan, O. Damburaci, N. Hardwickt, R. and Safranek, P. Sujendran, V. Bennett, J. Afzal, Z. and Shrotri, M. Chan, B. Exarchou, K. Gilbert, T. Amalesh, T. Mukherjee, D. Mukherjee, S. Wiggins, T. H. Kennedy, R. McCain, S. Harris, A. Dobson, G. Davies, N. and Wilson, I. Mayo, D. Bennett, D. Young, R. Manby, P. and Blencowe, N. Schiller, M. Byrne, B. Mitton, D. Wong, V. and Elshaer, A. Cowen, M. Menon, V. Tan, L. C. and McLaughlin, E. Koshy, R. Sharp, C. Brewer, H. Das, N. and Cox, M. Al Khyatt, W. Worku, D. Iqbal, R. Walls, L. and McGregor, R. Fullarton, G. Macdonald, A. MacKay, C. and Craig, C. Dwerryhouse, S. Hornby, S. Jaunoo, S. Wadley, M. Baker, C. Saad, M. Kelly, M. Davies, A. Di Maggio, F. McKay, S. Mistry, P. Singhal, R. Tucker, O. and Kapoulas, S. Powell-Brett, S. Davis, P. Bromley, G. and Watson, L. Verma, R. Ward, J. Shetty, V. Ball, C. and Pursnani, K. Sarela, A. Sue, Ling H. Mehta, S. Hayden, J. To, N. Palser, T. Hunter, D. Supramaniam, K. and Butt, Z. Ahmed, A. Kumar, S. Chaudry, A. Moussa, O. and Kordzadeh, A. Lorenzi, B. Wilson, M. Patil, P. Noaman, I. Willem, J. Bouras, G. Evans, R. Singh, M. and Warrilow, H. Ahmad, A. Tewari, N. Yanni, F. Couch, J. and Theophilidou, E. Reilly, J. J. Singh, P. van Boxel, Gijs and Akbari, K. Zanotti, D. Sgromo, B. Sanders, G. and Wheatley, T. Ariyarathenam, A. Reece-Smith, A. Humphreys, L. and Choh, C. Carter, N. Knight, B. Pucher, P. and Athanasiou, A. Mohamed, I. Tan, B. Abdulrahman, M. and Vickers, J. Akhtar, K. Chaparala, R. Brown, R. Alasmar, M. M. A. Ackroyd, R. Patel, K. Tamhankar, A. Wyman, A. and Walker, R. Grace, B. Abbassi, N. Slim, N. Ioannidi, L. Blackshaw, G. Havard, T. Escofet, X. Powell, A. and Owera, A. Rashid, F. Jambulingam, P. Padickakudi, J. and Ben-Younes, H. Mccormack, K. Makey, I. A. Karush, M. K. and Seder, C. W. Liptay, M. J. Chmielewski, G. Rosato, E. L. and Berger, A. C. Zheng, R. Okolo, E. Singh, A. Scott, C. D. and Weyant, M. J. Mitchell, J. D. Oesophago-Gastric Anastomotic
Abstract: Background: No evidence currently exists characterising global outcomes following major cancer surgery, including esophageal cancer. Therefore, this study aimed to characterise impact of high income countries (HIC) versus low and middle income countries (LMIC) on the outcomes following esophagectomy for esophageal cancer. Method: This international multi-center prospective study across 137 hospitals in 41 countries included patients who underwent an esophagectomy for esophageal cancer, with 90-day follow-up. The main explanatory variable was country income, defined according to the World Bank Data classification. The primary outcome was 90-day postoperative mortality, and secondary outcomes were composite leaks (anastomotic leak or conduit necrosis) and major complications (Clavien-Dindo Grade III-V). Multivariable generalized estimating equation models were used to produce adjusted odds ratios (ORs) and 95% confidence intervals (CI95%). Results: Between April 2018 to December 2018, 2247 patients were included. Patients from HIC were more significantly older, with higher ASA grade, and more advanced tumors. Patients from LMIC had almost three-fold increase in 90-day mortality, compared to HIC (9.4% vs 3.7%, p < 0.001). On adjusted analysis, LMIC were independently associated with higher 90-day mortality (OR: 2.31, CI95%: 1.17-4.55, p = 0.015). However, LMIC were not independently associated with higher rates of anastomotic leaks (OR: 1.06, CI95%: 0.57-1.99, p = 0.9) or major complications (OR: 0.85, CI95%: 0.54-1.32, p = 0.5), compared to HIC. Conclusion: Resections in LMIC were independently associated with higher 90-day postoperative mortality, likely reflecting a failure to rescue of these patients following esophagectomy, despite similar composite anastomotic leaks and major complication rates to HIC. These findings warrant further research, to identify potential issues and solutions to improve global outcomes following esophagectomy for cancer. (C) 2020 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Published: 2021

8. Postoperative outcomes in oesophagectomy with trainee involvement

Author: Evans, R. P. T. Hodson, J. Kamarajah, S. K. Griffiths, E. A. and Singh, P. Alderson, D. Bundred, J. Gossage, J. and Jefferies, B. McKay, S. Mohamed, I Nepogodiev, D. and Siaw-Acheampong, K. van Hillegersberg, R. Vohra, R. and Wanigasooriya, K. Whitehouse, T. Gjata, A. Moreno, I, J. and Takeda, F. R. Kidane, B. Castro, R. Guevara Harustiak, T. and Bekele, A. Kechagias, A. Gockel, I Kennedy, A. Da Roit, A. Bagajevas, A. Azagra, J. S. Mahendran, H. A. and Mejia-Fernandez, L. Wijnhoven, B. P. L. El Kafsi, J. Sayyed, R. H. Sousa, M. Sampaio, A. S. Negoi, I Blanco, R. and Wallner, B. Schneider, P. M. Hsu, P. K. Isik, A. and Gananadha, S. Wills, V Devadas, M. Duong, C. Talbot, M. and Hii, M. W. Jacobs, R. Andreollo, N. A. Johnston, B. and Darling, G. Isaza-Restrepo, A. Rosero, G. Arias-Amezquita, F. Raptis, D. Gaedcke, J. Reim, D. Izbicki, J. and Egberts, J. H. Dikinis, S. Kjaer, D. W. Larsen, M. H. and Achiam, M. P. Saarnio, J. Theodorou, D. Liakakos, T. and Korkolis, D. P. Robb, W. B. Collins, C. Murphy, T. and Reynolds, J. Tonini, V Migliore, M. Bonavina, L. and Valmasoni, M. Bardini, R. Weindelmayer, J. Terashima, M. and White, R. E. Alghunaim, E. Elhadi, M. Leon-Takahashi, A. M. and Medina-Franco, H. Lau, P. C. Okonta, K. E. Heisterkamp, J. Rosman, C. Beban, G. Babor, R. Gordon, A. and Rossaak, I, J. Pal, I, K. M. Qureshi, A. U. Naqi, S. A. and Syed, A. A. Barbosa, J. Vicente, C. S. Leite, J. Freire, J. Casaca, R. Costa, R. C. T. Scurtu, R. R. Mogoanta, S. S. Bolca, C. Constantinoiu, S. Sekhniaidze, D. So, J. B. Y. Gacvski, G. Loureiro, C. Pera, M. Bianchi, A. and Gijon, M. Moreno Fernandez, J. Martin Carrera, M. S. Trugeda and Vallve-Bernal, M. Pascual, M. A. Citores Elmahi, S. and Halldestam, I Hedberg, J. Monig, S. Gutknecht, S. Tez, M. Guner, A. Tirnaksiz, T. B. Colak, E. Sevinc, B. and Hindmarsh, A. Khan, I Khoo, D. Byrom, R. Gokhale, J. and Wilkerson, P. Jain, P. Chan, D. Robertson, K. Iftikhar, S. Skipworth, R. Forshaw, M. Higgs, S. Nijjar, R. and Viswanath, Y. K. S. Turner, P. Dexter, S. Boddy, A. and Allum, W. H. Oglesby, S. Cheong, E. Beardsmore, D. and Maynard, N. Berrisford, R. Mercer, S. Puig, S. Melhado, R. Kelty, C. Underwood, T. Dawas, K. Lewis, W. and Al-Bahrani, A. Bryce, G. Thomas, M. Arndt, A. T. and Palazzo, F. Meguid, R. A. Fergusson, J. Beenen, E. and Mosse, C. Salim, J. Cheah, S. Wright, T. Cerdeira, M. P. and McQuillan, P. Richardson, M. Liem, H. Spillane, J. and Yacob, M. Albadawi, F. Thorpe, T. Dingle, A. Cabalag, C. and Loi, K. Fisher, O. M. Ward, S. Read, M. Johnson, M. and Bassari, R. Bui, H. Cecconello, I Sallum, R. A. A. and da Rocha, J. R. M. Lopes, L. R. Tercioti, Jr., V. Coelho, J. D. S. Ferrer, J. A. P. Buduhan, G. Tan, L. Srinathan, S. and Shea, P. Yeung, J. Allison, F. Carroll, P. and Vargas-Barato, F. Gonzalez, F. Ortega, J. Nino-Torres, L. and Beltran-Garcia, T. C. Castilla, L. Pineda, M. Bastidas, A. Gomez-Mayorga, J. Cortes, N. Cetares, C. Caceres, S. and Duarte, S. Pazdro, A. Snajdauf, M. Faltova, H. and Sevcikova, M. Mortensen, P. B. Katballe, N. Ingemann, T. and Morten, B. Kruhlikava, I Ainswort, A. P. Stilling, N. M. and Eckardt, J. Holm, J. Thorsteinsson, M. Siemsen, M. and Brandt, B. Nega, B. Teferra, E. Tizazu, A. Kauppila, J. S. Koivukangas, V Merilainen, S. Gruetzmann, R. Krautz, C. Weber, G. Golcher, H. Emons, G. Azizian, A. and Ebeling, M. Niebisch, S. Kreuser, N. Albanese, G. Hesse, J. Volovnik, L. Boecher, U. Reeh, M. Triantafyllou, S. and Schizas, D. Michalinos, A. Baili, E. Mpoura, M. and Charalabopoulos, A. Manatakis, D. K. Balalis, D. Bolger, J. and Baban, C. Mastrosimone, A. McAnena, O. Quinn, A. and Suilleabhain, C. B. O. Hennessy, M. M. Ivanovski, I. Khizer, H. Ravi, N. Donlon, N. Cervellera, M. Vaccari, S. and Bianchini, S. Sartarelli, L. Asti, E. Bernardi, D. and Merigliano, S. Provenzano, L. Scarpa, M. Saadeh, L. and Salmaso, B. De Manzoni, G. Giacopuzzi, S. La Mendola, R. and De Pasqual, C. A. Tsubosa, Y. Niihara, M. Irino, T. and Makuuchi, R. Ishii, K. Mwachiro, M. Fekadu, A. Odera, A. and Mwachiro, E. AlShehab, D. Ahmed, H. A. Shebani, A. O. and Elhadi, A. Elnagar, F. A. Elnagar, H. F. Makkai-Popa, S. T. Wong, L. F. Yunrong, T. Thanninalai, S. Aik, H. C. and Soon, P. W. Huei, T. J. Basave, H. N. L. and Cortes-Gonzalez, R. Lagarde, S. M. van Lanschot, J. J. B. and Cords, C. Jansen, W. A. Martijnse, I Matthijsen, R. and Bouwense, S. Klarenbeek, B. Verstegen, M. van Workum, F. and Ruurda, J. P. van der Veen, A. van den Berg, J. W. Evenett, N. Johnston, P. Patel, R. MacCormick, A. Young, M. and Smith, B. Ekwunife, C. Memon, A. H. Shaikh, K. Wajid, A. and Khalil, N. Haris, M. Mirza, Z. U. Qudus, S. B. A. and Sarwar, M. Z. Shehzadi, A. Raza, A. Jhanzaib, M. H. and Farmanali, J. Zakir, Z. Shakeel, O. Nasir, I Khattak, S. and Baig, M. Noor, M. A. Ahmed, H. H. Naeem, A. Pinho, A. C. da Silva, R. Bernardes, A. Campos, J. C. Matos, H. and Braga, T. Monteiro, C. Ramos, P. Cabral, F. Gomes, M. P. Martins, P. C. Correia, A. M. Videira, J. F. and Ciuce, C. Drasovean, R. Apostu, R. Paitici, S. Racu, A. E. Obleaga, V, C. Beuran, M. Stoica, B. Ciubotaru, C. and Negoita, V Cordos, I Birla, R. D. Predescu, D. and Hoara, P. A. Tomsa, R. Shneider, V Agasiev, M. Ganjara, I Gunjic, D. Veselinovic, M. Babic, T. Chin, T. S. and Shabbir, A. Kim, G. Crnjac, A. Samo, H. del Val, I. Diez and Leturio, S. Ramon, J. M. Dal Cero, M. Rifa, S. Rico, M. Pomar, A. Pagan Corcoles, J. A. Martinez Miravalles, J. L. Rodicio Pais, S. A. Turienzo, S. A. Alvarez, L. S. and Campos, V, P. Rendo, A. G. Garcia, S. S. Santos, E. P. G. and Martinez, E. T. Diaz, M. J. Fernandez Alvarez, C. Magadan and Martin, V. Concepcion Lopez, C. Diaz Rodrigo, A. Rosat and Sanchez, L. E. Perez Cuadrado, M. Bailon Carrasco, C. Tinoco and Bhojwani, E. Choolani Sanchez, D. P. Ahmed, M. E. Dzhendov, T. Lindberg, F. Rutegard, M. Sundbom, M. Mickael, C. and Colucci, N. Schnider, A. Er, S. Kurnaz, E. Turkyilmaz, S. Turkyilmaz, A. Yildirim, R. Baki, B. E. Akkapulu, N. and Karahan, O. Damburaci, N. Hardwick, R. Safranek, P. and Sujendran, V Bennett, J. Afzal, Z. Shrotri, M. Chan, B. and Exarchou, K. Gilbert, T. Amalesh, T. Mukherjee, D. and Mukherjee, S. Wiggins, T. H. Kennedy, R. McCain, S. and Harris, A. Dobson, G. Davies, N. Wilson, I Mayo, D. and Bennett, D. Young, R. Manby, P. Blencowe, N. Schiller, M. Byrne, B. Mitton, D. Wong, V Elshaer, A. Cowen, M. Menon, V Tan, L. C. McLaughlin, E. Koshy, R. and Sharp, C. Brewer, H. Das, N. Cox, M. Al Khyatt, W. and Worku, D. Iqbal, R. Walls, L. McGregor, R. Fullarton, G. and Macdonald, A. MacKay, C. Craig, C. Dwerryhouse, S. and Hornby, S. Jaunoo, S. Wadley, M. Baker, C. Saad, M. and Kelly, M. Davies, A. Di Maggio, F. Mistry, P. Singhal, R. Tucker, O. Kapoulas, S. Powell-Brett, S. Davis, P. and Bromley, G. Watson, L. Verma, R. Ward, J. Shetty, V and Ball, C. Pursnani, K. Sarela, A. Ling, H. Sue Mehta, S. Hayden, J. To, N. Palser, T. Hunter, D. and Supramaniam, K. Butt, Z. Ahmed, A. Kumar, S. Chaudry, A. and Moussa, O. Kordzadeh, A. Patil, P. Noaman, I Willem, J. Bouras, G. Evans, R. Singh, M. Warrilow, H. and Ahmad, A. Tewari, N. Yanni, F. Couch, J. Theophilidou, E. Reilly, J. J. van Boxel, G. Akbari, K. Zanotti, D. and Sgromo, B. Sanders, G. Wheatley, T. Ariyarathenam, A. and Reece-Smith, A. Humphreys, L. Choh, C. Carter, N. and Knight, B. Pucher, P. Athanasiou, A. Tan, B. and Abdulrahman, M. Vickers, J. Akhtar, K. Chaparala, R. and Brown, R. Alasmar, M. M. A. Ackroyd, R. Patel, K. and Tamhankar, A. Wyman, A. Walker, R. Grace, B. Abbassi, N. and Slim, N. Ioannidi, L. Blackshaw, G. Havard, T. and Escofet, X. Powell, A. Owera, A. Rashid, F. Jambulingam, P. Padickakudi, J. Ben-Younes, H. McCormack, K. Makey, I. A. Karush, M. K. Seder, C. W. Liptay, M. J. and Chmielewski, G. Rosato, E. L. Berger, A. C. Zheng, R. and Okolo, E. Singh, A. Scott, C. D. Weyant, M. J. Mitchell, J. D. West Midlands Res Collaborative
Abstract: Background The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusion Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on perioperative outcomes in the international multicentre Oesophago-Gastric Anastomosis Audit (OGAA). Analysis of 2232 oesophagectomies has shown that trainee involvement did not negatively impact perioperative outcomes.
Published: 2021

9. Postoperative outcomes in oesophagectomy with trainee involvement

Author: Evans, R. P. (R. P. T.), Hodson, J. (J.), Kamarajah, S. K. (S. K.), Griffiths, E. A. (E. A.), Singh, P. (P.), Alderson, D. (D.), Bundred, J. (J.), Gossage, J. (J.), Jefferies, B. (B.), McKay, S. (S.), Mohamed, I. (I), Nepogodiev, D. (D.), Siaw-Acheampong, K. (K.), van Hillegersberg, R. (R.), Vohra, R. (R.), Wanigasooriya, K. (K.), Whitehouse, T. (T.), Gjata, A. (A.), Moreno, J. I. (J., I), Takeda, F. R. (F. R.), Kidane, B. (B.), Castro, R. G. (R. Guevara), Harustiak, T. (T.), Bekele, A. (A.), Kechagias, A. (A.), Gockel, I. (I), Kennedy, A. (A.), Da Roit, A. (A.), Bagajevas, A. (A.), Azagra, J. S. (J. S.), Mahendran, H. A. (H. A.), Mejia-Fernandez, L. (L.), Wijnhoven, B. P. (B. P. L.), El Kafsi, J. (J.), Sayyed, R. H. (R. H.), Sousa, M. (M.), Sampaio, A. S. (A. S.), Negoi, I. (I), Blanco, R. (R.), Wallner, B. (B.), Schneider, P. M. (P. M.), Hsu, P. K. (P. K.), Isik, A. (A.), Gananadha, S. (S.), Wills, V. (V), Devadas, M. (M.), Duong, C. (C.), Talbot, M. (M.), Hii, M. W. (M. W.), Jacobs, R. (R.), Andreollo, N. A. (N. A.), Johnston, B. (B.), Darling, G. (G.), Isaza-Restrepo, A. (A.), Rosero, G. (G.), Arias-Amezquita, F. (F.), Raptis, D. (D.), Gaedcke, J. (J.), Reim, D. (D.), Izbicki, J. (J.), Egberts, J. H. (J. H.), Dikinis, S. (S.), Kjaer, D. W. (D. W.), Larsen, M. H. (M. H.), Achiam, M. P. (M. P.), Saarnio, J. (J.), Theodorou, D. (D.), Liakakos, T. (T.), Korkolis, D. P. (D. P.), Robb, W. B. (W. B.), Collins, C. (C.), Murphy, T. (T.), Reynolds, J. (J.), Tonini, V. (V), Migliore, M. (M.), Bonavina, L. (L.), Valmasoni, M. (M.), Bardini, R. (R.), Weindelmayer, J. (J.), Terashima, M. (M.), White, R. E. (R. E.), Alghunaim, E. (E.), Elhadi, M. (M.), Leon-Takahashi, A. M. (A. M.), Medina-Franco, H. (H.), Lau, P. C. (P. C.), Okonta, K. E. (K. E.), Heisterkamp, J. (J.), Rosman, C. (C.), Beban, G. (G.), Babor, R. (R.), Gordon, A. (A.), Rossaak, J. I. (J., I), Pal, K. M. (K. M., I), Qureshi, A. U. (A. U.), Naqi, S. A. (S. A.), Syed, A. A. (A. A.), Barbosa, J. (J.), Vicente, C. S. (C. S.), Leite, J. (J.), Freire, J. (J.), Casaca, R. (R.), Costa, R. C. (R. C. T.), Scurtu, R. R. (R. R.), Mogoanta, S. S. (S. S.), Bolca, C. (C.), Constantinoiu, S. (S.), Sekhniaidze, D. (D.), So, J. B. (J. B. Y.), Gacvski, G. (G.), Loureiro, C. (C.), Pera, M. (M.), Bianchi, A. (A.), Gijon, M. M. (M. Moreno), Fernandez, J. M. (J. Martin), Carrera, M. S. (M. S. Trugeda), Vallve-Bernal, M. (M.), Pascual, M. A. (M. A. Citores), Elmahi, S. (S.), Halldestam, I. (I), Hedberg, J. (J.), Monig, S. (S.), Gutknecht, S. (S.), Tez, M. (M.), Guner, A. (A.), Tirnaksiz, T. B. (T. B.), Colak, E. (E.), Sevinc, B. (B.), Hindmarsh, A. (A.), Khan, I. (I), Khoo, D. (D.), Byrom, R. (R.), Gokhale, J. (J.), Wilkerson, P. (P.), Jain, P. (P.), Chan, D. (D.), Robertson, K. (K.), Iftikhar, S. (S.), Skipworth, R. (R.), Forshaw, M. (M.), Higgs, S. (S.), Nijjar, R. (R.), Viswanath, Y. K. (Y. K. S.), Turner, P. (P.), Dexter, S. (S.), Boddy, A. (A.), Allum, W. H. (W. H.), Oglesby, S. (S.), Cheong, E. (E.), Beardsmore, D. (D.), Maynard, N. (N.), Berrisford, R. (R.), Mercer, S. (S.), Puig, S. (S.), Melhado, R. (R.), Kelty, C. (C.), Underwood, T. (T.), Dawas, K. (K.), Lewis, W. (W.), Al-Bahrani, A. (A.), Bryce, G. (G.), Thomas, M. (M.), Arndt, A. T. (A. T.), Palazzo, F. (F.), Meguid, R. A. (R. A.), Fergusson, J. (J.), Beenen, E. (E.), Mosse, C. (C.), Salim, J. (J.), Cheah, S. (S.), Wright, T. (T.), Cerdeira, M. P. (M. P.), McQuillan, P. (P.), Richardson, M. (M.), Liem, H. (H.), Spillane, J. (J.), Yacob, M. (M.), Albadawi, F. (F.), Thorpe, T. (T.), Dingle, A. (A.), Cabalag, C. (C.), Loi, K. (K.), Fisher, O. M. (O. M.), Ward, S. (S.), Read, M. (M.), Johnson, M. (M.), Bassari, R. (R.), Bui, H. (H.), Cecconello, I. (I), Sallum, R. A. (R. A. A.), da Rocha, J. R. (J. R. M.), Lopes, L. R. (L. R.), Tercioti, V. J. (V., Jr.), Coelho, J. D. (J. D. S.), Ferrer, J. A. (J. A. P.), Buduhan, G. (G.), Tan, L. (L.), Srinathan, S. (S.), Shea, P. (P.), Yeung, J. (J.), Allison, F. (F.), Carroll, P. (P.), Vargas-Barato, F. (F.), Gonzalez, F. (F.), Ortega, J. (J.), Nino-Torres, L. (L.), Beltran-Garcia, T. C. (T. C.), Castilla, L. (L.), Pineda, M. (M.), Bastidas, A. (A.), Gomez-Mayorga, J. (J.), Cortes, N. (N.), Cetares, C. (C.), Caceres, S. (S.), Duarte, S. (S.), Pazdro, A. (A.), Snajdauf, M. (M.), Faltova, H. (H.), Sevcikova, M. (M.), Mortensen, P. B. (P. B.), Katballe, N. (N.), Ingemann, T. (T.), Morten, B. (B.), Kruhlikava, I. (I), Ainswort, A. P. (A. P.), Stilling, N. M. (N. M.), Eckardt, J. (J.), Holm, J. (J.), Thorsteinsson, M. (M.), Siemsen, M. (M.), Brandt, B. (B.), Nega, B. (B.), Teferra, E. (E.), Tizazu, A. (A.), Kauppila, J. S. (J. S.), Koivukangas, V. (V), Meriläinen, S. (S.), Gruetzmann, R. (R.), Krautz, C. (C.), Weber, G. (G.), Golcher, H. (H.), Emons, G. (G.), Azizian, A. (A.), Ebeling, M. (M.), Niebisch, S. (S.), Kreuser, N. (N.), Albanese, G. (G.), Hesse, J. (J.), Volovnik, L. (L.), Boecher, U. (U.), Reeh, M. (M.), Triantafyllou, S. (S.), Schizas, D. (D.), Michalinos, A. (A.), Baili, E. (E.), Mpoura, M. (M.), Charalabopoulos, A. (A.), Manatakis, D. K. (D. K.), Balalis, D. (D.), Bolger, J. (J.), Baban, C. (C.), Mastrosimone, A. (A.), McAnena, O. (O.), Quinn, A. (A.), Suilleabhain, C. B. (C. B. O.), Hennessy, M. M. (M. M.), Ivanovski, I. (I.), Khizer, H. (H.), Ravi, N. (N.), Donlon, N. (N.), Cervellera, M. (M.), Vaccari, S. (S.), Bianchini, S. (S.), Sartarelli, L. (L.), Asti, E. (E.), Bernardi, D. (D.), Merigliano, S. (S.), Provenzano, L. (L.), Scarpa, M. (M.), Saadeh, L. (L.), Salmaso, B. (B.), De Manzoni, G. (G.), Giacopuzzi, S. (S.), La Mendola, R. (R.), De Pasqual, C. A. (C. A.), Tsubosa, Y. (Y.), Niihara, M. (M.), Irino, T. (T.), Makuuchi, R. (R.), Ishii, K. (K.), Mwachiro, M. (M.), Fekadu, A. (A.), Odera, A. (A.), Mwachiro, E. (E.), AlShehab, D. (D.), Ahmed, H. A. (H. A.), Shebani, A. O. (A. O.), Elhadi, A. (A.), Elnagar, F. A. (F. A.), Elnagar, H. F. (H. F.), Makkai-Popa, S. T. (S. T.), Wong, L. F. (L. F.), Yunrong, T. (T.), Thanninalai, S. (S.), Aik, H. C. (H. C.), Soon, P. W. (P. W.), Huei, T. J. (T. J.), Basave, H. N. (H. N. L.), Cortes-Gonzalez, R. (R.), Lagarde, S. M. (S. M.), van Lanschot, J. J. (J. J. B.), Cords, C. (C.), Jansen, W. A. (W. A.), Martijnse, I. (I), Matthijsen, R. (R.), Bouwense, S. (S.), Klarenbeek, B. (B.), Verstegen, M. (M.), van Workum, F. (F.), Ruurda, J. P. (J. P.), van der Veen, A. (A.), van den Berg, J. W. (J. W.), Evenett, N. (N.), Johnston, P. (P.), Patel, R. (R.), MacCormick, A. (A.), Young, M. (M.), Smith, B. (B.), Ekwunife, C. (C.), Memon, A. H. (A. H.), Shaikh, K. (K.), Wajid, A. (A.), Khalil, N. (N.), Haris, M. (M.), Mirza, Z. U. (Z. U.), Qudus, S. B. (S. B. A.), Sarwar, M. Z. (M. Z.), Shehzadi, A. (A.), Raza, A. (A.), Jhanzaib, M. H. (M. H.), Farmanali, J. (J.), Zakir, Z. (Z.), Shakeel, O. (O.), Nasir, I. (I), Khattak, S. (S.), Baig, M. (M.), Noor, M. A. (M. A.), Ahmed, H. H. (H. H.), Naeem, A. (A.), Pinho, A. C. (A. C.), da Silva, R. (R.), Bernardes, A. (A.), Campos, J. C. (J. C.), Matos, H. (H.), Braga, T. (T.), Monteiro, C. (C.), Ramos, P. (P.), Cabral, F. (F.), Gomes, M. P. (M. P.), Martins, P. C. (P. C.), Correia, A. M. (A. M.), Videira, J. F. (J. F.), Ciuce, C. (C.), Drasovean, R. (R.), Apostu, R. (R.), Paitici, S. (S.), Racu, A. E. (A. E.), Obleaga, C. V. (C., V), Beuran, M. (M.), Stoica, B. (B.), Ciubotaru, C. (C.), Negoita, V. (V), Cordos, I. (I), Birla, R. D. (R. D.), Predescu, D. (D.), Hoara, P. A. (P. A.), Tomsa, R. (R.), Shneider, V. (V), Agasiev, M. (M.), Ganjara, I. (I), Gunjic, D. (D.), Veselinovic, M. (M.), Babic, T. (T.), Chin, T. S. (T. S.), Shabbir, A. (A.), Kim, G. (G.), Crnjac, A. (A.), Samo, H. (H.), del Val, I. D. (I. Diez), Leturio, S. (S.), Ramon, J. M. (J. M.), Dal Cero, M. (M.), Rifa, S. (S.), Rico, M. (M.), Pomar, A. P. (A. Pagan), Corcoles, J. A. (J. A. Martinez), Miravalles, J. L. (J. L. Rodicio), Pais, S. A. (S. A.), Turienzo, S. A. (S. A.), Alvarez, L. S. (L. S.), Campos, P. V. (P., V), Rendo, A. G. (A. G.), Garcia, S. S. (S. S.), Santos, E. P. (E. P. G.), Martinez, E. T. (E. T.), Diaz, M. J. (M. J. Fernandez), Alvarez, C. M. (C. Magadan), Martin, V. C. (V. Concepcion), Lopez, C. D. (C. Diaz), Rodrigo, A. R. (A. Rosat), Sanchez, L. E. (L. E. Perez), Cuadrado, M. B. (M. Bailon), Carrasco, C. T. (C. Tinoco), Bhojwani, E. C. (E. Choolani), Sanchez, D. P. (D. P.), Ahmed, M. E. (M. E.), Dzhendov, T. (T.), Lindberg, F. (F.), Rutegard, M. (M.), Sundbom, M. (M.), Mickael, C. (C.), Colucci, N. (N.), Schnider, A. (A.), Er, S. (S.), Kurnaz, E. (E.), Turkyilmaz, S. (S.), Turkyilmaz, A. (A.), Yildirim, R. (R.), Baki, B. E. (B. E.), Akkapulu, N. (N.), Karahan, O. (O.), Damburaci, N. (N.), Hardwick, R. (R.), Safranek, P. (P.), Sujendran, V. (V), Bennett, J. (J.), Afzal, Z. (Z.), Shrotri, M. (M.), Chan, B. (B.), Exarchou, K. (K.), Gilbert, T. (T.), Amalesh, T. (T.), Mukherjee, D. (D.), Mukherjee, S. (S.), Wiggins, T. H. (T. H.), Kennedy, R. (R.), McCain, S. (S.), Harris, A. (A.), Dobson, G. (G.), Davies, N. (N.), Wilson, I. (I), Mayo, D. (D.), Bennett, D. (D.), Young, R. (R.), Manby, P. (P.), Blencowe, N. (N.), Schiller, M. (M.), Byrne, B. (B.), Mitton, D. (D.), Wong, V. (V), Elshaer, A. (A.), Cowen, M. (M.), Menon, V. (V), Tan, L. C. (L. C.), McLaughlin, E. (E.), Koshy, R. (R.), Sharp, C. (C.), Brewer, H. (H.), Das, N. (N.), Cox, M. (M.), Al Khyatt, W. (W.), Worku, D. (D.), Iqbal, R. (R.), Walls, L. (L.), McGregor, R. (R.), Fullarton, G. (G.), Macdonald, A. (A.), MacKay, C. (C.), Craig, C. (C.), Dwerryhouse, S. (S.), Hornby, S. (S.), Jaunoo, S. (S.), Wadley, M. (M.), Baker, C. (C.), Saad, M. (M.), Kelly, M. (M.), Davies, A. (A.), Di Maggio, F. (F.), Mistry, P. (P.), Singhal, R. (R.), Tucker, O. (O.), Kapoulas, S. (S.), Powell-Brett, S. (S.), Davis, P. (P.), Bromley, G. (G.), Watson, L. (L.), Verma, R. (R.), Ward, J. (J.), Shetty, V. (V), Ball, C. (C.), Pursnani, K. (K.), Sarela, A. (A.), Ling, H. S. (H. Sue), Mehta, S. (S.), Hayden, J. (J.), To, N. (N.), Palser, T. (T.), Hunter, D. (D.), Supramaniam, K. (K.), Butt, Z. (Z.), Ahmed, A. (A.), Kumar, S. (S.), Chaudry, A. (A.), Moussa, O. (O.), Kordzadeh, A. (A.), Patil, P. (P.), Noaman, I. (I), Willem, J. (J.), Bouras, G. (G.), Evans, R. (R.), Singh, M. (M.), Warrilow, H. (H.), Ahmad, A. (A.), Tewari, N. (N.), Yanni, F. (F.), Couch, J. (J.), Theophilidou, E. (E.), Reilly, J. J. (J. J.), van Boxel, G. (G.), Akbari, K. (K.), Zanotti, D. (D.), Sgromo, B. (B.), Sanders, G. (G.), Wheatley, T. (T.), Ariyarathenam, A. (A.), Reece-Smith, A. (A.), Humphreys, L. (L.), Choh, C. (C.), Carter, N. (N.), Knight, B. (B.), Pucher, P. (P.), Athanasiou, A. (A.), Tan, B. (B.), Abdulrahman, M. (M.), Vickers, J. (J.), Akhtar, K. (K.), Chaparala, R. (R.), Brown, R. (R.), Alasmar, M. M. (M. M. A.), Ackroyd, R. (R.), Patel, K. (K.), Tamhankar, A. (A.), Wyman, A. (A.), Walker, R. (R.), Grace, B. (B.), Abbassi, N. (N.), Slim, N. (N.), Ioannidi, L. (L.), Blackshaw, G. (G.), Havard, T. (T.), Escofet, X. (X.), Powell, A. (A.), Owera, A. (A.), Rashid, F. (F.), Jambulingam, P. (P.), Padickakudi, J. (J.), Ben-Younes, H. (H.), McCormack, K. (K.), Makey, I. A. (I. A.), Karush, M. K. (M. K.), Seder, C. W. (C. W.), Liptay, M. J. (M. J.), Chmielewski, G. (G.), Rosato, E. L. (E. L.), Berger, A. C. (A. C.), Zheng, R. (R.), Okolo, E. (E.), Singh, A. (A.), Scott, C. D. (C. D.), Weyant, M. J. (M. J.), Mitchell, J. D. (J. D.), Evans, R. P. (R. P. T.), Hodson, J. (J.), Kamarajah, S. K. (S. K.), Griffiths, E. A. (E. A.), Singh, P. (P.), Alderson, D. (D.), Bundred, J. (J.), Gossage, J. (J.), Jefferies, B. (B.), McKay, S. (S.), Mohamed, I. (I), Nepogodiev, D. (D.), Siaw-Acheampong, K. (K.), van Hillegersberg, R. (R.), Vohra, R. (R.), Wanigasooriya, K. (K.), Whitehouse, T. (T.), Gjata, A. (A.), Moreno, J. I. (J., I), Takeda, F. R. (F. R.), Kidane, B. (B.), Castro, R. G. (R. Guevara), Harustiak, T. (T.), Bekele, A. (A.), Kechagias, A. (A.), Gockel, I. (I), Kennedy, A. (A.), Da Roit, A. (A.), Bagajevas, A. (A.), Azagra, J. S. (J. S.), Mahendran, H. A. (H. A.), Mejia-Fernandez, L. (L.), Wijnhoven, B. P. (B. P. L.), El Kafsi, J. (J.), Sayyed, R. H. (R. H.), Sousa, M. (M.), Sampaio, A. S. (A. S.), Negoi, I. (I), Blanco, R. (R.), Wallner, B. (B.), Schneider, P. M. (P. M.), Hsu, P. K. (P. K.), Isik, A. (A.), Gananadha, S. (S.), Wills, V. (V), Devadas, M. (M.), Duong, C. (C.), Talbot, M. (M.), Hii, M. W. (M. W.), Jacobs, R. (R.), Andreollo, N. A. (N. A.), Johnston, B. (B.), Darling, G. (G.), Isaza-Restrepo, A. (A.), Rosero, G. (G.), Arias-Amezquita, F. (F.), Raptis, D. (D.), Gaedcke, J. (J.), Reim, D. (D.), Izbicki, J. (J.), Egberts, J. H. (J. H.), Dikinis, S. (S.), Kjaer, D. W. (D. W.), Larsen, M. H. (M. H.), Achiam, M. P. (M. P.), Saarnio, J. (J.), Theodorou, D. (D.), Liakakos, T. (T.), Korkolis, D. P. (D. P.), Robb, W. B. (W. B.), Collins, C. (C.), Murphy, T. (T.), Reynolds, J. (J.), Tonini, V. (V), Migliore, M. (M.), Bonavina, L. (L.), Valmasoni, M. (M.), Bardini, R. (R.), Weindelmayer, J. (J.), Terashima, M. (M.), White, R. E. (R. E.), Alghunaim, E. (E.), Elhadi, M. (M.), Leon-Takahashi, A. M. (A. M.), Medina-Franco, H. (H.), Lau, P. C. (P. C.), Okonta, K. E. (K. E.), Heisterkamp, J. (J.), Rosman, C. (C.), Beban, G. (G.), Babor, R. (R.), Gordon, A. (A.), Rossaak, J. I. (J., I), Pal, K. M. (K. M., I), Qureshi, A. U. (A. U.), Naqi, S. A. (S. A.), Syed, A. A. (A. A.), Barbosa, J. (J.), Vicente, C. S. (C. S.), Leite, J. (J.), Freire, J. (J.), Casaca, R. (R.), Costa, R. C. (R. C. T.), Scurtu, R. R. (R. R.), Mogoanta, S. S. (S. S.), Bolca, C. (C.), Constantinoiu, S. (S.), Sekhniaidze, D. (D.), So, J. B. (J. B. Y.), Gacvski, G. (G.), Loureiro, C. (C.), Pera, M. (M.), Bianchi, A. (A.), Gijon, M. M. (M. Moreno), Fernandez, J. M. (J. Martin), Carrera, M. S. (M. S. Trugeda), Vallve-Bernal, M. (M.), Pascual, M. A. (M. A. Citores), Elmahi, S. (S.), Halldestam, I. (I), Hedberg, J. (J.), Monig, S. (S.), Gutknecht, S. (S.), Tez, M. (M.), Guner, A. (A.), Tirnaksiz, T. B. (T. B.), Colak, E. (E.), Sevinc, B. (B.), Hindmarsh, A. (A.), Khan, I. (I), Khoo, D. (D.), Byrom, R. (R.), Gokhale, J. (J.), Wilkerson, P. (P.), Jain, P. (P.), Chan, D. (D.), Robertson, K. (K.), Iftikhar, S. (S.), Skipworth, R. (R.), Forshaw, M. (M.), Higgs, S. (S.), Nijjar, R. (R.), Viswanath, Y. K. (Y. K. S.), Turner, P. (P.), Dexter, S. (S.), Boddy, A. (A.), Allum, W. H. (W. H.), Oglesby, S. (S.), Cheong, E. (E.), Beardsmore, D. (D.), Maynard, N. (N.), Berrisford, R. (R.), Mercer, S. (S.), Puig, S. (S.), Melhado, R. (R.), Kelty, C. (C.), Underwood, T. (T.), Dawas, K. (K.), Lewis, W. (W.), Al-Bahrani, A. (A.), Bryce, G. (G.), Thomas, M. (M.), Arndt, A. T. (A. T.), Palazzo, F. (F.), Meguid, R. A. (R. A.), Fergusson, J. (J.), Beenen, E. (E.), Mosse, C. (C.), Salim, J. (J.), Cheah, S. (S.), Wright, T. (T.), Cerdeira, M. P. (M. P.), McQuillan, P. (P.), Richardson, M. (M.), Liem, H. (H.), Spillane, J. (J.), Yacob, M. (M.), Albadawi, F. (F.), Thorpe, T. (T.), Dingle, A. (A.), Cabalag, C. (C.), Loi, K. (K.), Fisher, O. M. (O. M.), Ward, S. (S.), Read, M. (M.), Johnson, M. (M.), Bassari, R. (R.), Bui, H. (H.), Cecconello, I. (I), Sallum, R. A. (R. A. A.), da Rocha, J. R. (J. R. M.), Lopes, L. R. (L. R.), Tercioti, V. J. (V., Jr.), Coelho, J. D. (J. D. S.), Ferrer, J. A. (J. A. P.), Buduhan, G. (G.), Tan, L. (L.), Srinathan, S. (S.), Shea, P. (P.), Yeung, J. (J.), Allison, F. (F.), Carroll, P. (P.), Vargas-Barato, F. (F.), Gonzalez, F. (F.), Ortega, J. (J.), Nino-Torres, L. (L.), Beltran-Garcia, T. C. (T. C.), Castilla, L. (L.), Pineda, M. (M.), Bastidas, A. (A.), Gomez-Mayorga, J. (J.), Cortes, N. (N.), Cetares, C. (C.), Caceres, S. (S.), Duarte, S. (S.), Pazdro, A. (A.), Snajdauf, M. (M.), Faltova, H. (H.), Sevcikova, M. (M.), Mortensen, P. B. (P. B.), Katballe, N. (N.), Ingemann, T. (T.), Morten, B. (B.), Kruhlikava, I. (I), Ainswort, A. P. (A. P.), Stilling, N. M. (N. M.), Eckardt, J. (J.), Holm, J. (J.), Thorsteinsson, M. (M.), Siemsen, M. (M.), Brandt, B. (B.), Nega, B. (B.), Teferra, E. (E.), Tizazu, A. (A.), Kauppila, J. S. (J. S.), Koivukangas, V. (V), Meriläinen, S. (S.), Gruetzmann, R. (R.), Krautz, C. (C.), Weber, G. (G.), Golcher, H. (H.), Emons, G. (G.), Azizian, A. (A.), Ebeling, M. (M.), Niebisch, S. (S.), Kreuser, N. (N.), Albanese, G. (G.), Hesse, J. (J.), Volovnik, L. (L.), Boecher, U. (U.), Reeh, M. (M.), Triantafyllou, S. (S.), Schizas, D. (D.), Michalinos, A. (A.), Baili, E. (E.), Mpoura, M. (M.), Charalabopoulos, A. (A.), Manatakis, D. K. (D. K.), Balalis, D. (D.), Bolger, J. (J.), Baban, C. (C.), Mastrosimone, A. (A.), McAnena, O. (O.), Quinn, A. (A.), Suilleabhain, C. B. (C. B. O.), Hennessy, M. M. (M. M.), Ivanovski, I. (I.), Khizer, H. (H.), Ravi, N. (N.), Donlon, N. (N.), Cervellera, M. (M.), Vaccari, S. (S.), Bianchini, S. (S.), Sartarelli, L. (L.), Asti, E. (E.), Bernardi, D. (D.), Merigliano, S. (S.), Provenzano, L. (L.), Scarpa, M. (M.), Saadeh, L. (L.), Salmaso, B. (B.), De Manzoni, G. (G.), Giacopuzzi, S. (S.), La Mendola, R. (R.), De Pasqual, C. A. (C. A.), Tsubosa, Y. (Y.), Niihara, M. (M.), Irino, T. (T.), Makuuchi, R. (R.), Ishii, K. (K.), Mwachiro, M. (M.), Fekadu, A. (A.), Odera, A. (A.), Mwachiro, E. (E.), AlShehab, D. (D.), Ahmed, H. A. (H. A.), Shebani, A. O. (A. O.), Elhadi, A. (A.), Elnagar, F. A. (F. A.), Elnagar, H. F. (H. F.), Makkai-Popa, S. T. (S. T.), Wong, L. F. (L. F.), Yunrong, T. (T.), Thanninalai, S. (S.), Aik, H. C. (H. C.), Soon, P. W. (P. W.), Huei, T. J. (T. J.), Basave, H. N. (H. N. L.), Cortes-Gonzalez, R. (R.), Lagarde, S. M. (S. M.), van Lanschot, J. J. (J. J. B.), Cords, C. (C.), Jansen, W. A. (W. A.), Martijnse, I. (I), Matthijsen, R. (R.), Bouwense, S. (S.), Klarenbeek, B. (B.), Verstegen, M. (M.), van Workum, F. (F.), Ruurda, J. P. (J. P.), van der Veen, A. (A.), van den Berg, J. W. (J. W.), Evenett, N. (N.), Johnston, P. (P.), Patel, R. (R.), MacCormick, A. (A.), Young, M. (M.), Smith, B. (B.), Ekwunife, C. (C.), Memon, A. H. (A. H.), Shaikh, K. (K.), Wajid, A. (A.), Khalil, N. (N.), Haris, M. (M.), Mirza, Z. U. (Z. U.), Qudus, S. B. (S. B. A.), Sarwar, M. Z. (M. Z.), Shehzadi, A. (A.), Raza, A. (A.), Jhanzaib, M. H. (M. H.), Farmanali, J. (J.), Zakir, Z. (Z.), Shakeel, O. (O.), Nasir, I. (I), Khattak, S. (S.), Baig, M. (M.), Noor, M. A. (M. A.), Ahmed, H. H. (H. H.), Naeem, A. (A.), Pinho, A. C. (A. C.), da Silva, R. (R.), Bernardes, A. (A.), Campos, J. C. (J. C.), Matos, H. (H.), Braga, T. (T.), Monteiro, C. (C.), Ramos, P. (P.), Cabral, F. (F.), Gomes, M. P. (M. P.), Martins, P. C. (P. C.), Correia, A. M. (A. M.), Videira, J. F. (J. F.), Ciuce, C. (C.), Drasovean, R. (R.), Apostu, R. (R.), Paitici, S. (S.), Racu, A. E. (A. E.), Obleaga, C. V. (C., V), Beuran, M. (M.), Stoica, B. (B.), Ciubotaru, C. (C.), Negoita, V. (V), Cordos, I. (I), Birla, R. D. (R. D.), Predescu, D. (D.), Hoara, P. A. (P. A.), Tomsa, R. (R.), Shneider, V. (V), Agasiev, M. (M.), Ganjara, I. (I), Gunjic, D. (D.), Veselinovic, M. (M.), Babic, T. (T.), Chin, T. S. (T. S.), Shabbir, A. (A.), Kim, G. (G.), Crnjac, A. (A.), Samo, H. (H.), del Val, I. D. (I. Diez), Leturio, S. (S.), Ramon, J. M. (J. M.), Dal Cero, M. (M.), Rifa, S. (S.), Rico, M. (M.), Pomar, A. P. (A. Pagan), Corcoles, J. A. (J. A. Martinez), Miravalles, J. L. (J. L. Rodicio), Pais, S. A. (S. A.), Turienzo, S. A. (S. A.), Alvarez, L. S. (L. S.), Campos, P. V. (P., V), Rendo, A. G. (A. G.), Garcia, S. S. (S. S.), Santos, E. P. (E. P. G.), Martinez, E. T. (E. T.), Diaz, M. J. (M. J. Fernandez), Alvarez, C. M. (C. Magadan), Martin, V. C. (V. Concepcion), Lopez, C. D. (C. Diaz), Rodrigo, A. R. (A. Rosat), Sanchez, L. E. (L. E. Perez), Cuadrado, M. B. (M. Bailon), Carrasco, C. T. (C. Tinoco), Bhojwani, E. C. (E. Choolani), Sanchez, D. P. (D. P.), Ahmed, M. E. (M. E.), Dzhendov, T. (T.), Lindberg, F. (F.), Rutegard, M. (M.), Sundbom, M. (M.), Mickael, C. (C.), Colucci, N. (N.), Schnider, A. (A.), Er, S. (S.), Kurnaz, E. (E.), Turkyilmaz, S. (S.), Turkyilmaz, A. (A.), Yildirim, R. (R.), Baki, B. E. (B. E.), Akkapulu, N. (N.), Karahan, O. (O.), Damburaci, N. (N.), Hardwick, R. (R.), Safranek, P. (P.), Sujendran, V. (V), Bennett, J. (J.), Afzal, Z. (Z.), Shrotri, M. (M.), Chan, B. (B.), Exarchou, K. (K.), Gilbert, T. (T.), Amalesh, T. (T.), Mukherjee, D. (D.), Mukherjee, S. (S.), Wiggins, T. H. (T. H.), Kennedy, R. (R.), McCain, S. (S.), Harris, A. (A.), Dobson, G. (G.), Davies, N. (N.), Wilson, I. (I), Mayo, D. (D.), Bennett, D. (D.), Young, R. (R.), Manby, P. (P.), Blencowe, N. (N.), Schiller, M. (M.), Byrne, B. (B.), Mitton, D. (D.), Wong, V. (V), Elshaer, A. (A.), Cowen, M. (M.), Menon, V. (V), Tan, L. C. (L. C.), McLaughlin, E. (E.), Koshy, R. (R.), Sharp, C. (C.), Brewer, H. (H.), Das, N. (N.), Cox, M. (M.), Al Khyatt, W. (W.), Worku, D. (D.), Iqbal, R. (R.), Walls, L. (L.), McGregor, R. (R.), Fullarton, G. (G.), Macdonald, A. (A.), MacKay, C. (C.), Craig, C. (C.), Dwerryhouse, S. (S.), Hornby, S. (S.), Jaunoo, S. (S.), Wadley, M. (M.), Baker, C. (C.), Saad, M. (M.), Kelly, M. (M.), Davies, A. (A.), Di Maggio, F. (F.), Mistry, P. (P.), Singhal, R. (R.), Tucker, O. (O.), Kapoulas, S. (S.), Powell-Brett, S. (S.), Davis, P. (P.), Bromley, G. (G.), Watson, L. (L.), Verma, R. (R.), Ward, J. (J.), Shetty, V. (V), Ball, C. (C.), Pursnani, K. (K.), Sarela, A. (A.), Ling, H. S. (H. Sue), Mehta, S. (S.), Hayden, J. (J.), To, N. (N.), Palser, T. (T.), Hunter, D. (D.), Supramaniam, K. (K.), Butt, Z. (Z.), Ahmed, A. (A.), Kumar, S. (S.), Chaudry, A. (A.), Moussa, O. (O.), Kordzadeh, A. (A.), Patil, P. (P.), Noaman, I. (I), Willem, J. (J.), Bouras, G. (G.), Evans, R. (R.), Singh, M. (M.), Warrilow, H. (H.), Ahmad, A. (A.), Tewari, N. (N.), Yanni, F. (F.), Couch, J. (J.), Theophilidou, E. (E.), Reilly, J. J. (J. J.), van Boxel, G. (G.), Akbari, K. (K.), Zanotti, D. (D.), Sgromo, B. (B.), Sanders, G. (G.), Wheatley, T. (T.), Ariyarathenam, A. (A.), Reece-Smith, A. (A.), Humphreys, L. (L.), Choh, C. (C.), Carter, N. (N.), Knight, B. (B.), Pucher, P. (P.), Athanasiou, A. (A.), Tan, B. (B.), Abdulrahman, M. (M.), Vickers, J. (J.), Akhtar, K. (K.), Chaparala, R. (R.), Brown, R. (R.), Alasmar, M. M. (M. M. A.), Ackroyd, R. (R.), Patel, K. (K.), Tamhankar, A. (A.), Wyman, A. (A.), Walker, R. (R.), Grace, B. (B.), Abbassi, N. (N.), Slim, N. (N.), Ioannidi, L. (L.), Blackshaw, G. (G.), Havard, T. (T.), Escofet, X. (X.), Powell, A. (A.), Owera, A. (A.), Rashid, F. (F.), Jambulingam, P. (P.), Padickakudi, J. (J.), Ben-Younes, H. (H.), McCormack, K. (K.), Makey, I. A. (I. A.), Karush, M. K. (M. K.), Seder, C. W. (C. W.), Liptay, M. J. (M. J.), Chmielewski, G. (G.), Rosato, E. L. (E. L.), Berger, A. C. (A. C.), Zheng, R. (R.), Okolo, E. (E.), Singh, A. (A.), Scott, C. D. (C. D.), Weyant, M. J. (M. J.), and Mitchell, J. D. (J. D.)
Abstract: Background: The complexity of oesophageal surgery and the significant risk of morbidity necessitates that oesophagectomy is predominantly performed by a consultant surgeon, or a senior trainee under their supervision. The aim of this study was to determine the impact of trainee involvement in oesophagectomy on postoperative outcomes in an international multicentre setting. Methods: Data from the multicentre Oesophago-Gastric Anastomosis Study Group (OGAA) cohort study were analysed, which comprised prospectively collected data from patients undergoing oesophagectomy for oesophageal cancer between April 2018 and December 2018. Procedures were grouped by the level of trainee involvement, and univariable and multivariable analyses were performed to compare patient outcomes across groups. Results: Of 2232 oesophagectomies from 137 centres in 41 countries, trainees were involved in 29.1 per cent of them (n = 650), performing only the abdominal phase in 230, only the chest and/or neck phases in 130, and all phases in 315 procedures. For procedures with a chest anastomosis, those with trainee involvement had similar 90-day mortality, complication and reoperation rates to consultant-performed oesophagectomies (P = 0.451, P = 0.318, and P = 0.382, respectively), while anastomotic leak rates were significantly lower in the trainee groups (P = 0.030). Procedures with a neck anastomosis had equivalent complication, anastomotic leak, and reoperation rates (P = 0.150, P = 0.430, and P = 0.632, respectively) in trainee-involved versus consultant-performed oesophagectomies, with significantly lower 90-day mortality in the trainee groups (P = 0.005). Conclusions: Trainee involvement was not found to be associated with significantly inferior postoperative outcomes for selected patients undergoing oesophagectomy. The results support continued supervised trainee involvement in oesophageal cancer surgery.
Published: 2021

10. International Variation in Surgical Practices in Units Performing Oesophagectomy for Oesophageal Cancer: A Unit Survey from the Oesophago-Gastric Anastomosis Audit (OGAA)

Author: Bundred, J. R., Kamarajah, S. K., Siaw-Acheampong, K., Nepogodiev, D., Jefferies, B., Singh, P., Evans, R., Griffiths, E. A., Alderson, D., Gossage, J., Mckay, S., Mohamed, I., van Hillegersberg, R., Vohra, R., Wanigsooriya, K., Whitehouse, T., Bagajevas, A., Bekele, A., Blanco-Colino, R., Da Roit, A., El Kafsi-Mawley, J., Gjata, A., Gockel, I., Castro, R. G., Harustiak, T., Hsu, P. -K., Isik, A., Kechagias, A., Kennedy, A., Kidane, B., Mahendran, H. A., Mejia, L., Moreno, J. I., Negoi, I., Santiago, A. J., Sayyed, R., Schneider, P., Soares, A. S., Sousa, M., Takeda, F. R., Vanstraten, S., Wallner, B., Wijnhoven, B., Achiam, M., Agustin, T., Akbar, A., Al-Bahrani, A., Al-Khyatt, W., Albertsmeier, M., Alghunaim, E., Alkhaffaf, B., Allum, W., Am, F., Andreollo, N., Arndt, A., Babor, R., Barbosa, J., Bardini, R., Beardsmore, D., Beban, G., Bernardes, A., Berrisford, R., Bianchi, A., Bjelovic, M., Boddy, A., Bolca, C., Bonavina, L., Bryce, G., Byrom, R., Casaca, R., Chan, D., Charalabopoulos, A., Cheong, E., Ciotola, F., Colak, E., Collins, C., Constantinoiu, S., Costa, R., Dahlke, M., Darling, G., Dawas, K., de Manzoni, G., Denewer, A., Devadas, M., Dexter, S., Dikinis, S., Dimitrios, T., Dolan, J., Duong, C., Egberts, J. -H., Elgharably, Y., Elhadi, M., Elmahi, S., Farias, F. A., Fekaj, E., Fernandez, J., Forshaw, M., Freire, J., French, D., Gacevski, G., Gaedcke, J., Gananadha, S., Gijon, M. M., Gokhale, J., Gordon, A., Grimminger, P., Guevara, R., Guner, A., Gutknecht, S., Mahmoodzadeh, H., Halldestam, I., Hedberg, J., Heisterkamp, J., Higgs, S., Hii, M., Hindmarsh, A., Hoppner, J., Isaza, A., Izbicki, J., Jacobs, R., Jain, P., Johansson, J., Johnston, B., Kafsi, J., Kassa, S., Kelty, C., Khan, I., Khoo, D., Khyatt, S., Kjaer, D., Korkolis, D., Kreuser, N., Larsen, M., Lau, P., Leite, J., Lewis, W., Liakakos, T., Loureiro, C., Mahendran, A., Maynard, N., Mcgregor, R., Mcnally, S., Medina-Franco, H., Meguid, R., Melhado, R., Mercer, S., Migliore, M., Mingol, F., Mogoanta, S., Mohri, Y., Monig, S., Moreno, J., Motas, N., Murphy, T., Naqi, S., Ni, R., Niazi, S., Oglesby, S., Okonta, K., Ortiz, S. R., Pal, K., Palazzo, F., Pascher, A., Pascual, M., Pata, G., Pera, M., Puig, S., Ramirez, J., Raptis, D., Rasanen, J., Reim, D., Reynolds, J., Robb, W., Robertson, K., Rosero, G., Rosman, C., Rossaak, J., Saarnio, J., Santiago, A., Schiesser, M., Scurtu, R. -R., Sekhniaidze, D., Sevinc, B., Skipworth, R., So, J., Trugeda, M. S., Syed, A., Takahashi, A. M. L., Takeda, F., Talbot, M., Tareen, M., Terashima, M., Testini, M., Tewari, N., Tez, M., Thomas, M., Tirnaksiz, M., Tonini, V., C. -C., Tu, Turner, P., Underwood, T., Uzair, A., Vallve-Bernal, M., Valmasoni, M., Vicente, C., Videira, J. F., Viswanath, Y., Weindelmayer, J., White, R., Wigle, D., Wilkerson, P., Wills, V., Zacharakis, E., Zuluaga, M., Surgery, Moenig, Stefan Paul, Bundred J.R., Kamarajah S.K., Siaw-Acheampong K., Nepogodiev D., Jefferies B., Singh P., Evans R., Griffiths E.A., Alderson D., Gossage J., McKay S., Mohamed I., van Hillegersberg R., Vohra R., Wanigsooriya K., Whitehouse T., Bagajevas A., Bekele A., Blanco-Colino R., Da Roit A., El Kafsi-Mawley J., Gjata A., Gockel I., Castro R.G., Harustiak T., Hsu P.-K., Isik A., Kechagias A., Kennedy A., Kidane B., Mahendran H.A., Mejia L., Moreno J.I., Negoi I., Santiago A.J., Sayyed R., Schneider P., Soares A.S., Sousa M., Takeda F.R., Vanstraten S., Wallner B., Wijnhoven B., Achiam M., Agustin T., Akbar A., Al-Bahrani A., Al-Khyatt W., Albertsmeier M., Alghunaim E., Alkhaffaf B., Allum W., Am F., Andreollo N., Arndt A., Babor R., Barbosa J., Bardini R., Beardsmore D., Beban G., Bernardes A., Berrisford R., Bianchi A., Bjelovic M., Boddy A., Bolca C., Bonavina L., Bryce G., Byrom R., Casaca R., Chan D., Charalabopoulos A., Cheong E., Ciotola F., Colak E., Collins C., Constantinoiu S., Costa R., Dahlke M., Darling G., Dawas K., de Manzoni G., Denewer A., Devadas M., Dexter S., Dikinis S., Dimitrios T., Dolan J., Duong C., Egberts J.-H., Elgharably Y., Elhadi M., Elmahi S., Farias F.A., Fekaj E., Fernandez J., Forshaw M., Freire J., French D., Gacevski G., Gaedcke J., Gananadha S., Gijon M.M., Gokhale J., Gordon A., Grimminger P., Guevara R., Guner A., Gutknecht S., Mahmoodzadeh H., Halldestam I., Hedberg J., Heisterkamp J., Higgs S., Hii M., Hindmarsh A., Hoppner J., Isaza A., Izbicki J., Jacobs R., Jain P., Johansson J., Johnston B., Kafsi J., Kassa S., Kelty C., Khan I., Khoo D., Khyatt S., Kjaer D., Korkolis D., Kreuser N., Larsen M., Lau P., Leite J., Lewis W., Liakakos T., Loureiro C., Mahendran A., Maynard N., Mcgregor R., Mcnally S., Medina-Franco H., Meguid R., Melhado R., Mercer S., Migliore M., Mingol F., Mogoanta S., Mohri Y., Monig S., Moreno J., Motas N., Murphy T., Naqi S., Ni R., Niazi S., Oglesby S., Okonta K., Ortiz S.R., Pal K., Palazzo F., Pascher A., Pascual M., Pata G., Pera M., Puig S., Ramirez J., Raptis D., Rasanen J., Reim D., Reynolds J., Robb W., Robertson K., Rosero G., Rosman C., Rossaak J., Saarnio J., Santiago A., Schiesser M., Scurtu R.-R., Sekhniaidze D., Sevinc B., Skipworth R., So J., Trugeda M.S., Syed A., Takahashi A.M.L., Takeda F., Talbot M., Tareen M., Terashima M., Testini M., Tewari N., Tez M., Thomas M., Tirnaksiz M., Tonini V., Tu C.-C., Turner P., Underwood T., Uzair A., Vallve-Bernal M., Valmasoni M., Vicente C., Videira J.F., Viswanath Y., Weindelmayer J., White R., Wigle D., Wilkerson P., Wills V., Zacharakis E., and Zuluaga M.
Subjects: Leak, medicine.medical_specialty, Internationality, Oesophagectomy , Oesophageal Cancer: Oesophago-Gastric Anastomosis, complications, Esophageal Neoplasms, Anastomosis, Anastomotic Leak, Audit, Anastomosis, Surgical, Developed Countries, Developing Countries, Drainage, Esophagectomy, Hospital Units, Humans, Stents, Surveys and Questionnaires, Enhanced Recovery After Surgery, Unit (housing), 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Anastomotic leaks, Surgical, medicine, Journal Article, Response rate (survey), medicine.diagnostic_test, ddc:617, business.industry, General surgery, Cancer, Interventional radiology, medicine.disease, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, business
Abstract: Background: Anastomotic leaks are associated with significant risk of morbidity, mortality and treatment costs after oesophagectomy. The aim of this study was to evaluate international variation in unit-level clinical practice and resource availability for the prevention and management of anastomotic leak following oesophagectomy.Method: The Oesophago-Gastric Anastomosis Audit (OGAA) is an international research collaboration focussed on improving the care and outcomes of patients undergoing oesophagectomy. Any unit performing oesophagectomy worldwide can register to participate in OGAA studies. An online unit survey was developed and disseminated to lead surgeons at each unit registered to participate in OGAA. High-income country (HIC) and low/middle-income country (LMIC) were defined according to the World Bank whilst unit volume were defined as < 20 versus 20-59 versus ≥60 cases/year in the unit.Results: Responses were received from 141 units, a 77% (141/182) response rate. Median annual oesophagectomy caseload was reported to be 26 (inter-quartile range 12-50). Only 48% (68/141) and 22% (31/141) of units had an Enhanced Recovery After Surgery (ERAS) program and ERAS nurse, respectively. HIC units had significantly higher rates of stapled anastomosis compared to LMIC units (66 vs 31%, p = 0.005). Routine post-operative contrast-swallow anastomotic assessment was performed in 52% (73/141) units. Stent placement and interventional radiology drainage for anastomotic leak management were more commonly available in HICs than LMICs (99 vs 59%, p < 0.001 and 99 vs 83%, p < 0.001).Conclusions: This international survey highlighted variation in surgical technique and management of anastomotic leak based on case volume and country income level. Further research is needed to understand the impact of this variation on patient outcomes.
Published: 2019

11. Treatment of achalasia: lessons learned with Chagasʼ disease

Author: Herbella, F. A. M., Aquino, J. L. B., Stefani-Nakano, S., Artifon, E. L. A., Sakai, P., Crema, E., Andreollo, N. A., Lopes, L. R., de Castro Pochini, C., Corsi, P. R., Gagliardi, D., and Del Grande, J. C.
Published: 2008

12. Experimental esophageal carcinogenesis: technical standardization and results

Author: Sallet, J. A., Zilberstein, B., Andreollo, N. A., Eshkenazy, R., and Pajecki, D.
Published: 2002

13. The 2018 ISDE achalasia guidelines

Author: Zaninotto, G, primary, Bennett, C, additional, Boeckxstaens, G, additional, Costantini, M, additional, Ferguson, M K, additional, Pandolfino, J E, additional, Patti, M G, additional, Ribeiro, U, additional, Richter, J, additional, Swanstrom, L, additional, Tack, J, additional, Triadafilopoulos, G, additional, Markar, S R, additional, Salvador, R, additional, Faccio, L, additional, Andreollo, N A, additional, Cecconello, I, additional, Costamagna, G, additional, da Rocha, J R M, additional, Hungness, E S, additional, Fisichella, P M, additional, Fuchs, K H, additional, Gockel, I, additional, Gurski, R, additional, Gyawali, C P, additional, Herbella, F A M, additional, Holloway, R H, additional, Hongo, M, additional, Jobe, B A, additional, Kahrilas, P J, additional, Katzka, D A, additional, Dua, K S, additional, Liu, D, additional, Moonen, A, additional, Nasi, A, additional, Pasricha, P J, additional, Penagini, R, additional, Perretta, S, additional, Sallum, R A A, additional, Sarnelli, G, additional, Savarino, E, additional, Schlottmann, F, additional, Sifrim, D, additional, Soper, N, additional, Tatum, R P, additional, Vaezi, M F, additional, van Herwaarden-Lindeboom, M, additional, Vanuytsel, T, additional, Vela, M F, additional, Watson, D I, additional, Zerbib, F, additional, Gittens, S, additional, Pontillo, C, additional, Vermigli, S, additional, Inama, D, additional, and Low, D E, additional
Published: 2018
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14. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity

Author: Virginio, V. W. M., primary, Nunes, V. S., additional, Moura, F. A., additional, Menezes, F. H., additional, Andreollo, N. A., additional, Rogerio, F., additional, Scherrer, D. Z., additional, Quintão, E. C. R., additional, Nakandakare, E., additional, Petrucci, O., additional, Nadruz-Junior, W., additional, de Faria, E. C., additional, and Sposito, A. C., additional
Published: 2014
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15. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity.

Author: Virginio, V. W. M., Nunes, V. S., Moura, F. A., Menezes, F. H., Andreollo, N. A., Rogerio, F., Scherrer, D. Z., Quintão, E. C. R., Nakandakare, E., Petrucci, O., Nadruz-Junior, W., de Faria, E. C., and Sposito, A. C.
Subjects: OXYSTEROLS, ATHEROSCLEROTIC plaque, CHOLESTEROL derivatives, FREE radicals, REACTIVE oxygen species, C-reactive protein
Abstract: Introduction. Cholesterol undergoes oxidation via both enzymatic stress- and free radical-mediated mechanisms, generating a wide range of oxysterols. In contrast to oxidative stress-driven metabolites, enzymatic stress-derived oxysterols are scarcely studied in their association with atherosclerotic disease in humans. Methods. 24S-hydroxycholesterol (24S-HC), 25-hydroxycholesterol (25-HC), and 27-hydroxycholesterol (27-HC) were assessed in plasma and arteries with atherosclerotic plaques from 10 patients (54-84 years) with severe peripheral artery disease (PAD) as well as arteries free of atherosclerotic plaques from 13 individuals (45-78 years, controls). Results. Plasma 25-HC was higher in PAD individuals than in controls (6.3[2] vs. 3.9[1.9] ng/mgCol; p = 0.004). 24S-HC and 27-HC levels were, respectively, five- and 20-fold higher in the arterial tissue of PAD individuals than in those of the controls ( p = 0.016 and p = 0.001). Plasma C-reactive protein correlated with plasma 24-HC ( r = 0.51; p = 0.010), 25-HC ( r = 0.75; p < 0.001), 27-HC ( r = 0.48; p = 0.015), and with tissue 24S-HC ( r = 0.4; p = 0.041) and 27-HC ( r = 0.46; p = 0.023). Conclusion. Arterial intima accumulation of 27-HC and 24S-HC is associated with advanced atherosclerotic disease and systemic inflammatory activity in individuals with severe PAD. [ABSTRACT FROM AUTHOR]
Published: 2015
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16. Tratamento cirúrgico videolaparoscópico da doença do refluxo gastroesofagiano: técnica de Nissen modificada - resultados clínicos e funcionais

Author: LOPES, L. R., primary, BRANDALISE, N. A., additional, ANDREOLLO, N. A., additional, and LEONARDI, L. S., additional
Published: 2001
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17. A laparoscopia no diagnóstico das doenças intra-abdominais. Análise de 168 casos

Author: Andreollo, N. A., primary, Coelho Neto, J. de S., additional, Lopes, L. R., additional, Brandalise, N. A., additional, and Leonardi, L. S., additional
Published: 1999
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18. Studies of the oesophageal clearance responses to intraluminal acid.

Author: Thompson, D G, Andreollo, N A, McIntyre, A S, and Earlam, R J
Abstract: Contraction of the upper oesophageal sphincter combined with secondary peristalsis clears the oesophagus of refluxed gastric contents and protects the trachea, but the nature of these reflex stimuli remains controversial. Secondary peristaltic and sphincteric responses were measured during intraluminal infusion of 0.1 N hydrochloric acid and equiosmolar saline solutions in seven normal volunteers. Responses to a single volume infused at varying sites in the oesophagus and to progressively increasing volumes of test solution were measured. In addition oesophageal responses to similar degrees of distension induced by inflation of an intraluminal balloon were also recorded. The sphincteric responses to both stimuli were similar, decreasing in value with distance from the sphincter from values of 70 (68-85) mmHg (median (range] for HCl; and 70 (55-85) mmHg for NaCl at 5 cm below the sphincter to 40 (30-60) mmHg for both HCl and NaCl at 20 cm. As the volume of the solution infused into the proximal oesophagus was increased, the sphincter pressure also rose from a median basal value of 30 (25-50) mmHg to 40 (30-50) mmHg for HCl and NaCl after 1 ml, while after 7 ml infusion, the responses were greater, 65 (45-85) mmHg for HCl, and 60 (45-80) mmHg for NaCl. In the more distal oesophagus, responses were qualitatively similar but quantitatively smaller than proximally, being 30 (25-40) mmHg for HCl and 30 (25-50) mmHg for NaCl following 1 ml and 45 (40-55) mmHg for HCl and NaCl after 7 ml. Secondary peristalsis was also induced equally by both solutions and varied with volumes infused and site of infusion in a manner similar to the sphincter responses. After a 7 ml/min acid infusion 14 (1- 40) secondary contractions/three min were recorded at 5 cm and eight (2 - 18)/three min were recorded at 20 cm. Values for saline were similar, 13 (1- 38)/three min at 5 cm and eight (4 - 25)/three min at 20 cm. Oesophageal distension by a balloon positioned 10 cm below the sphincter induced identical clearance responses to those seen after similar volumes of either acid or saline infused at the same site. These results suggest that the principal stimulus for upper oesophageal clearance is intraluminal distension and do not support the idea that the oesophagus is pH sensitive. [ABSTRACT FROM PUBLISHER]
Published: 1988

19. Functional relationships between cricopharyngeal sphincter and oesophageal body in response to graded intraluminal distension.

Author: Andreollo, N A, Thompson, D G, Kendall, G P, and Earlam, R J
Abstract: Responses of the cricopharyngeal sphincter to graded intraluminal distension were studied in order to determine its response threshold and to define the functional relationship between the sphincter and oesophageal body. Nine normal subjects underwent manometric study using a multilumen tube with an attached inflatable balloon sited 10 cm below the sphincter. Sphincteric and oesophageal motor responses to six graded balloon inflations were recorded in each subject. The sphincter responded to distension with increasing rise in pressure, from a median value of 42.5 mmHg at lowest levels of distension to 95 mmHg at maximal tolerated distension. Non-swallow related contractile activity was stimulated in the oesophageal body proximal to the distension and increased in quantity as inflation progressed. Distal propagation of this secondary activity was progressively inhibited with increasing distension. These interrelated changes thus show the normal upper oesophageal clearance responses to intraluminal distension. It is suggested that their more widespread application, in addition to standard manometric techniques, might provide a more rational evaluation of those patients suspected to have impaired oesophageal clearance, but in whom standard manometry is non-diagnostic. [ABSTRACT FROM PUBLISHER]
Published: 1988
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20. Heller's myotomy for achalasia: Is an added anti-reflux procedure necessary?

Author: Andreollo, N. A. and Earlam, R. J.
Published: 1987
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21. Brazilian consensus in gastric cancer: guidelines for gastric cancer in Brazil

Author: Zilberstein, B., Malheiros, C., Lourenço, L. G., Kassab, P., Jacob, C. E., Weston, A. C., Bresciani, C. J., Castro, O., Gama-Rodrigues, J., Borin, A. A., Buchpiegel, C., Montagnini, A., Leite, C. V., Deutsch, C. R., Kruel, C. D., Mucerino, D., Wohnrath, D., Ilias, E., Mrué, F., Maluf-Filho, F., Rocha, F., Souza, F., Tomasich, F. S., Ishak, G., Laporte, G., Souza, H. P., Ivan Cecconello, Eisig, J., Ohana, J., Sabagga, J., Del Grande, J. C., Jesus, J. P., Soares, J., Dias, L. A., Moreira, L. F., Correa, M., Carvalho, M., Andreollo, N. A., Áquila, N. D., Czeczko, N. G., Kruel, N., Forones, N. M., Da Motta, O. M., Malafaia, O., Assumpção, P., Leonardi, P., Sakai, P., Rocha, P. R., Colleoni, R., Gurgel, R., Coral, R. P., Chalub, S., Ribeiro- Junior, U., Alves, V. A., Vasquez, Vd El, and Nadalin, V.
Subjects: Stomach Neoplasms, Humans, Brazil
Abstract: In Brazil, gastric cancer is the fourth most common malignancy among men and sixth among women. The cause is multivariate and the risks are well known. It has prognosis and treatment defined by the location and staging of the tumor and number of lymph nodes resected and involved.The Brazilian Consensus on Gastric Cancer promoted by ABCG was designed with the intention to issue guidelines that can guide medical professionals to care for patients with this disease.Were summarized and answered 43 questions reflecting consensus or not on diagnosis and treatment that may be used as guidance for its multidisciplinary approach. The method involved three steps. Initially, 56 digestive surgeons and related medical specialties met to formulate the questions that were sent to participants for answers on scientific evidence and personal experience. Summaries were presented, discussed and voted in plenary in two other meetings. They covered 53 questions involving: diagnosis and staging (six questions); surgical treatment (35 questions); chemotherapy and radiotherapy (seven questions) and anatomopathology, immunohistochemistry and perspective (five questions). It was considered consensus agreement on more than 70% of the votes in each item.All the answers were presented and voted upon, and in 42 there was consensus.It could be developed consensus on most issues that come with the care of patients with gastric cancer and they can be transformed in guidelines.

22. Change the Qualis criteria! | Mudança dos critérios Qualis!

Author: Andriolo, A., Barbosa, A. J. A., Hernandez, A. J., Camargos, A. F., Benedito Barraviera, Kadunc, B. V., Caramelli, B., Brites, C., Do Nascimento, D. C., Braile, D. M., Goldenberg, D. C., Baracat, E. C., Marchiori, E., Paula Vieira, E., Almeida, E. A., Machado, F., Jotz, G. P., Kirsztajn, G. M., Camanho, G., Gusso, G., Duarte, I. G., Costa, I. M. C., Mello Jr, J. F., Faintuch, J., Martinez, J. A. B., Manso, J. E. F., Filho, J. E. C., Da Costa Montal, J. H., Do Amaral, J. L. G., Martins, J. L., Andrade, J. M., Savassi, L., Casulari, L. A., Leme, L. E. G., Moreira, L. F. P., Gebrim, L. H., Madeira, M., Riberto, M., Bastos, M., Falcão, M. C., Da Conceição, M. J., E Silva, M. R., Ruiz, M. A., Shibata, M. K., Santiago, M. B., Andreollo, N. A., Alonso, N., Malafaia, O., Camargo, O. P., Fernandes, P. M. P., Martins, R. H. G., Procianoy, R. S., Antunes, R. C. P., Fuller, R., Viebig, R. G., Nitrini, R., Dedivitis, R., Damião, R., Monteiro, R., Lianza, S., Mello Rode, S., Filho, T. E. P. B., Chamon, W., Yoshida, W. B., and Handar, Z.

23. Classification of Journals in the QUALIS System of CAPES - URGENT need of changing the criteria!

Author: Andriolo, A., Souza, A. F., Farias, A. Q., Barbosa, A. J., França Netto, A. S., Hernandez, A. J., Camargos, A. F., Barraviera, B., Kadunc, B. V., Caramelli, B., Campos, C. E., Brites, C., Do Nascimento, D. C., Braile, D. M., Goldenberg, D. C., Kimura, E. T., Marchiori, E., Vieira, E. E. P., Almeida, E. A., Jotz, G. P., Camanho, G., Friedman, G., Cerri, G. G., Duarte, I. G., Costa, I. M., Mello Júnior, J. F., Faintuch, J., Martinez, J. A., Livramento, J. A., Manso, J. E., Battistella, L. R., Machado, L. Os R., Moreira, L. F., Gebrim, L. H., Madeira, M., Marcelo Riberto, Bastos, M., Falcão, M. C., Da Conceição, M. J., Rocha E Silva, M., Ruiz, M. A., Shibata, M. K., Santiago, M. B., Andreollo, N. A., Malafaia, O., Martins, R. H., Procianoy, R. S., Baroudi, R., Fuller, R., Viebig, R. G., Nitrini, R., Moura, R. C., Dedivitis, R., Damião, R., Lianza, S., Rode, S. E. M., Yoshida, W. B., and Handar, Z.
Subjects: Quality Control, Government Agencies, Consensus Development Conferences as Topic, Journal Impact Factor, Periodicals as Topic, Brazil

24. Change the Qualis criteria!,Mudança dos critérios Qualis!

Author: Andriolo, A., Barbosa, A. J. A., Hernandez, A. J., Camargos, A. F., Barraviera, B., Kadunc, B. V., Caramelli, B., Brites, C., Do Nascimento, D. C., Braile, D. M., Goldenberg, D. C., Baracat, E. C., Marchiori, E., Paula Vieira, E., Almeida, E. A., Machado, F., Jotz, G. P., Kirsztajn, G. M., Camanho, G., Gusso, G., Duarte, I. G., Costa, I. M. C., Mello Jr, J. F., Faintuch, J., Martinez, J. A. B., Manso, J. E. F., Filho, J. E. C., Da Costa Montal, J. H., Do Amaral, J. L. G., Martins, J. L., Andrade, J. M., Savassi, L., Casulari, L. A., Leme, L. E. G., Moreira, L. F. P., Gebrim, L. H., Madeira, M., Riberto, M., Bastos, M., Falcão, M. C., Da Conceição, M. J., E Silva, M. R., Ruiz, M. A., Shibata, M. K., Santiago, M. B., Andreollo, N. A., nivaldo alonso, Malafaia, O., Camargo, O. P., Fernandes, P. M. P., Martins, R. H. G., Procianoy, R. S., Antunes, R. C. P., Fuller, R., Viebig, R. G., Nitrini, R., Dedivitis, R., Damião, R., Monteiro, R., Lianza, S., Mello Rode, S., Filho, T. E. P. B., Chamon, W., Yoshida, W. B., and Handar, Z.

25. [Classification of journals in the QUALIS system of CAPES: urgent need of changing the criteria!]

Author: Andriolo, A., Souza, A. F., Farias, A. Q., Barbosa, A. J., Netto, A. S., Hernandez, A. J., Camargos, A. F., Barraviera, B., Kadunc, B. V., Caramelli, B., Campos, C. E., Brites, C., Do Nascimento, D. C., Braile, D. M., Goldenberg, D. C., Baracat, E. C., Kimura, E. T., Marchiori, E., Almeida, E. A., Jotz, G. P., Camanho, G., Friedman, G., Cerri, G. G., Duarte, I. G., Costa, I. M., Mello Júnior, J. F., Faintuch, J. F., Martinez, J. A., Livramento, J. A., Manso, J. E., Do Amaral, J. L., Battistella, L. R., Dos Ramos Machado, L., Moreira, L. F., Gebrim, L. H., Madeira, M., Marcelo Riberto, Bastos, M., Falcão, M. C., Da Conceição, M. J., Rocha E Silva, M., Ruiz, M. A., Shibata, M. K., Santiago, M. B., Andreollo, N. A., Malafaia, O., Martins, R. H., Procianoy, R. S., Baroudi, R., Fuller, R., Viebig, R. G., Nitrini, R., Moura, R. C., Dedivitis, R., Damião, R., Lianza, S., Mello Rode, S., Yoshida, W. B., and Handar, Z.

26. The 2018 ISDE achalasia guidelines

Author: Giovanni Sarnelli, Tim Vanuytsel, Blair A. Jobe, Cathy Bennett, David I. Watson, Piero M. Fisichella, Ivan Cecconello, Ulysses Ribeiro, Richard H. Holloway, D. Liu, M. Y. A. van Herwaarden-Lindeboom, Edoardo Savarino, Rubens Antonio Aissar Sallum, Daniel Sifrim, David A. Katzka, Eric S. Hungness, John E. Pandolfino, Fernando A. M. Herbella, Silvana Perretta, Roger P. Tatum, Lee L. Swanstrom, Guy E. Boeckxstaens, Chandra Prakash Gyawali, Richard Ricachenevsky Gurski, Marco G. Patti, L. Faccio, George Triadafilopoulos, Nathaniel J. Soper, D. Inama, M. F. Vaezi, Frank Zerbib, Sheraz R. Markar, Joel E. Richter, An Moonen, S. Vermigli, Pankaj J. Pasricha, Ines Gockel, Nelson Adami Andreollo, Guido Costamagna, Peter J. Kahrilas, Francisco Schlottmann, Giovanni Zaninotto, Mark K. Ferguson, M. F. Vela, Stuart Gittens, Karl-Hermann Fuchs, Renato Salvador, Donald E. Low, C. Pontillo, J. R. M. Da Rocha, Jan Tack, Mario Costantini, Roberto Penagini, Kulwinder S. Dua, Michio Hongo, Ary Nasi, Zaninotto, G, Bennett, C, Boeckxstaens, G, Costantini, M, Ferguson, M K, Pandolfino, J E, Patti, M G, Ribeiro, U, Richter, J, Swanstrom, L, Tack, J, Triadafilopoulos, G, Markar, S R, Salvador, R, Faccio, L, Andreollo, N A, Cecconello, I, Costamagna, G, da Rocha, J R M, Hungness, E S, Fisichella, P M, Fuchs, K H, Gockel, I, Gurski, R, Gyawali, C P, Herbella, F A M, Holloway, R H, Hongo, M, Jobe, B A, Kahrilas, P J, Katzka, D A, Dua, K S, Liu, D, Moonen, A, Nasi, A, Pasricha, P J, Penagini, R, Perretta, S, Sallum, R A A, Sarnelli, G, Savarino, E, Schlottmann, F, Sifrim, D, Soper, N, Tatum, R P, Vaezi, M F, van Herwaarden-Lindeboom, M, Vanuytsel, T, Vela, M F, Watson, D I, Zerbib, F, Gittens, S, Pontillo, C, Vermigli, S, Inama, D, and Low, D E
Subjects: Adult, Male, Myotomy, Chagas disease, medicine.medical_specialty, Botulinum Toxins, medicine.medical_treatment, Achalasia, Esophageal Disorder, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Severity of illness, otorhinolaryngologic diseases, medicine, Humans, Disease management (health), Child, Evidence-Based Medicine, DIRETRIZES PARA A PRÁTICA CLÍNICA, business.industry, General surgery, Gastroenterology, Disease Management, achalaisa, guidelines, General Medicine, Evidence-based medicine, Guideline, medicine.disease, Dilatation, Dysphagia, Esophageal Achalasia, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Esophagoscopy, Symptom Assessment, medicine.symptom, business
Abstract: Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations of the lower esophageal sphincter and of peristalsis along the esophageal body. As a result, patients typically present with dysphagia, regurgitation and occasionally chest pain, pulmonary complication and malnutrition. New diagnostic methodologies and therapeutic techniques have been recently added to the armamentarium for treating achalasia. With the aim to offer clinicians and patients an up-to-date framework for making informed decisions on the management of this disease, the International Society for Diseases of the Esophagus Guidelines proposed and endorsed the Esophageal Achalasia Guidelines (I-GOAL). The guidelines were prepared according the Appraisal of Guidelines for Research and Evaluation (AGREE-REX) tool, accredited for guideline production by NICE UK. A systematic literature search was performed and the quality of evidence and the strength of recommendations were graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Given the relative rarity of this disease and the paucity of high-level evidence in the literature, this process was integrated with a three-step process of anonymous voting on each statement (DELPHI). Only statements with an approval rate >80% were accepted in the guidelines. Fifty-one experts from 11 countries and 3 representatives from patient support associations participated to the preparations of the guidelines. These guidelines deal specifically with the following achalasia issues: Diagnostic workup, Definition of the disease, Severity of presentation, Medical treatment, Botulinum Toxin injection, Pneumatic dilatation, POEM, Other endoscopic treatments, Laparoscopic myotomy, Definition of recurrence, Follow up and risk of cancer, Management of end stage achalasia, Treatment options for failure, Achalasia in children, Achalasia secondary to Chagas' disease.
Published: 2018

27. Role of nitrites in the genesis of adenocarcinoma associated with Barrett's esophagus.

Author: Modena SF, Meirelles LR, Araújo MR, Lopes LR, and Andreollo NA
Subjects: Adenocarcinoma pathology, Anastomosis, Surgical adverse effects, Animals, Barrett Esophagus pathology, Disease Models, Animal, Male, Precancerous Conditions etiology, Precancerous Conditions pathology, Rats, Rats, Wistar, Upper Gastrointestinal Tract surgery, Adenocarcinoma chemically induced, Barrett Esophagus chemically induced, Food Preservatives toxicity, Sodium Nitrite toxicity
Abstract: Background: Barrett's esophagus (BE) is one of the complications of gastroesophageal reflux disease (GERD) and a premalignant condition. It consists of a process of replacement of the squamous epithelium of the esophagus by intestinal columnar epithelium containing goblet cells, known as specialized intestinal metaplasia with goblet cells, and several factors have been related to its pathogenesis. The objective of this study was to evaluate an experimental model of duodenogastroesophageal reflux and the effect of ingestion of sodium nitrite solution on the genesis of adenocarcinoma associated with Barrett's esophagus., Materials and Methods: Sixty male Wistar rats were divided into four groups. Twenty were not submitted to surgery and served as controls (10 animals ingesting only water and 10 ingesting water plus a solution of sodium nitrite), while the remaining 40 animals were submitted to side-to-side duodenogastroesophageal anastomosis (20 animals ingesting only water and 20 ingesting water plus the sodium nitrite solution). The Vienna classification for dysplasia and adenocarcinoma was used in the analysis of results., Results: After 42 weeks of observation, Barrett's esophagus was found in 26.3% (5/19) of the animals submitted to surgery that had not ingested nitrites compared to 72.3% (13/18) of the animals in the group submitted to surgery and given nitrites. Six cases of adenocarcinoma (33.3%) were also found in this latter group. Barrett's esophagus was not found in any of the animals that were not submitted to surgery. Categories 2, 3 and 5 of the Vienna classification were only found in the animals submitted to surgery that also received sodium nitrite (66.7%)., Conclusion: The ingestion of sodium nitrite associated with duodenogastroesophageal reflux plays an important role in the genesis of adenocarcinoma associated with Barrett's esophagus.
Published: 2009

28. Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.

Author: Rossini A, Rapozo DC, Soares Lima SC, Guimarães DP, Ferreira MA, Teixeira R, Kruel CD, Barros SG, Andreollo NA, Acatauassú R, Matos HJ, Albano RM, and Pinto LF
Subjects: Adult, Aged, Aged, 80 and over, Alcohol Drinking, Brazil, Case-Control Studies, Cytochrome P-450 CYP2A6, Female, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Smoking, Aryl Hydrocarbon Hydroxylases genetics, Cytochrome P-450 CYP2E1 genetics, Esophageal Neoplasms genetics, Glutathione S-Transferase pi genetics, Glutathione Transferase genetics, Mixed Function Oxygenases genetics
Abstract: Esophageal cancer is among the most common and fatal tumors in the world. Eighty percent of esophageal tumors are esophageal squamous cell carcinoma (ESCC). Brazil is one of the high incidence areas in the West, where tobacco and alcohol consumption have been associated with ESCC. However, polymorphisms in xenobiotic metabolizing genes may also contribute to the risk. Therefore, in this study, we analyzed the risk of ESCC associated with tobacco and alcohol consumption and with polymorphisms of CYP2A6 (CYP2A6*2), CYP2E1 (CYP2E1*5B, CYP2E1*6), GSTP1 (Ile105Val), GSTM1 and GSTT1 null genotypes in 126 cases and 252 age- and gender-matched controls. Data on the amount, length and type of tobacco and alcohol consumed were collected, and DNA was extracted from blood lymphocytes from all individuals. Polymorphisms were analyzed by polymerase chain reaction (PCR)-multiplex (GSTM1 and T1), PCR-Restriction Fragment Length Polymorphism (CYP2E1*5B and *6 and GSTP1 Ile105Val) or allele-specific PCR amplification (CYP2A6*2). Risks were evaluated by multivariate conditional regression analysis. As expected, tobacco [odds ratio (OR) = 6.71, 95% confidence interval (95% CI) 3.08-14.63] and alcohol (OR = 16.98, CI 7.8-36.98) consumption, independently or together (OR = 26.91, CI 13.39-54.05) were risk factors. GSTP1 Ile105Val polymorphism was an independent risk factor (OR = 2.12, CI 1.37-3.29), whereas GSTT1 wild-type was an independent protective factor for ESCC (OR = 0.37, CI 0.16-0.79). There was approximately 80% statistical power to detect both results. There was no risk associated with CYP2A6, CYP2E1 and GSTM1 polymorphisms. In conclusion, this study suggests an opposite role of GSTP1 and GSTT1 polymorphisms for the risk for ESCC.
Published: 2007
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29. A functional study of caustic strictures of the esophagus in children.

Author: Da-Costa-Pinto EA, Dorsa TK, Altimani A, Andreollo NA, Cardoso SR, Morais DJ, and Bustorff-Silva JM
Subjects: Adolescent, Burns, Chemical etiology, Child, Child, Preschool, Esophageal Motility Disorders diagnostic imaging, Esophageal Motility Disorders physiopathology, Esophageal Stenosis diagnostic imaging, Esophageal Stenosis physiopathology, Humans, Manometry methods, Radionuclide Imaging, Severity of Illness Index, Burns, Chemical physiopathology, Esophageal Motility Disorders chemically induced, Esophageal Stenosis chemically induced, Sodium Hydroxide toxicity
Abstract: The objective of the present study was to assess esophageal motor function in 21 children (7.5 +/- 2.9 years) with caustic strictures. Esophageal manometry was performed using a water-infusion system interfaced with a polygraph and displayed on a computer screen. The data were compared with those obtained from 9 healthy children. Radionuclide transit was determined by studying deglutition of a single bolus of 99mTc pertechnetate in 10 ml of water. Non-peristaltic low-amplitude and long-duration waves were the most common findings detected in patients with strictures longer than 20% of esophageal length (N = 11). Compared with the control group, these patients presented lower mean amplitude and longer mean duration of waves (24.4 +/- 11.2 vs 97.9 +/- 23.7 mmHg, P < 0.05, and 6.7 +/- 2.4 vs 1.6 +/- 0.1 s, P < 0.05, respectively). Six patients presented low-amplitude waves just below the constricted site. Ten children presented delayed esophageal transit. There was an association between dysphagia and abnormalities on manometry (P = 0.02) and between symptoms and scintigraphy data (P = 0.01). Dysphagia in caustic strictures is due to esophageal motility abnormalities, which are closely related to the scarred segment.
Published: 2004
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30. Effect of surgical treatment on the cellular immune response of gastric cancer patients.

Author: Barbieri C, Fujisawa MM, Yasuda CL, Metze IL, Oliveira EC, Santos LM, Lopes LR, and Andreollo NA
Subjects: Adult, Aged, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunity, Cellular, Lymphocyte Count, Male, Middle Aged, Lymphocyte Subsets immunology, Stomach Neoplasms immunology, Stomach Neoplasms surgery, T-Lymphocytes, Helper-Inducer immunology, Transforming Growth Factor beta biosynthesis
Abstract: Patients with gastric cancer have a variety of immunological abnormalities. In the present study the lymphocytes and their subsets were determined in the peripheral blood of patients with gastric cancer (N = 41) both before and after surgical treatment. The percent of helper/inducer CD4 T cells (43.6 +/- 8.9) was not different after tumor resection (43.6 +/- 8.2). The percent of the cytotoxic CD8+ T cell population decreased significantly, whether patients were treated surgically (27.2 +/- 5.8%, N = 20) or not (27.3 +/- 7.3%, N = 20) compared to individuals with inflammatory disease (30.9 +/- 7.5%) or to healthy individuals (33.2 +/- 7.6%). The CD4/CD8 ratio consequently increased in the group of cancer patients. The peripheral blood lymphocytes of gastric cancer patients showed reduced responsiveness to mitogens. The defective blastogenic response of the lymphocytes was not associated with the production of transforming growth factor beta (TGF- ) since the patients with cancer had reduced production of TGF- Beta1 (269 +/- 239 pg/ml, N = 20) in comparison to the normal individuals (884 +/- 175 pg/ml, N = 20). These results indicate that the immune response of gastric cancer patients was not significantly modified by surgical treatment when evaluated four weeks after surgery and that the immunosuppression observed was not due to an increase in TGF- 1 production by peripheral leukocytes.
Published: 2003
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31. [Conservative treatment of benign esophageal strictures using dilation. Analysis of 500 cases].

Author: Andreollo NA, Lopes LR, Inogutti R, Brandalise NA, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Esophageal Stenosis etiology, Female, Humans, Male, Middle Aged, Treatment Outcome, Dilatation methods, Esophageal Stenosis therapy, Esophagoscopy methods
Abstract: Unlabelled: The benign esophageal stenoses (BES) are common complications owing to many etiologies: gastroesophageal reflux, ingestion of corrosive agents, esophageal surgery, radiotherapy, postendoscopic variceal sclerotherapy, drug ingestion, prolonged nasogastric intubation, extrinsic compression and esophageal webs. Esophageal dilatations are worldwide recommended to treat this complication, employing dilators of many types and diameters and facilitating the food ingestion., Purpose: Evaluation of the results and advantages of the conservative treatment of the BES using esophageal dilatations, in outpatient service of upper digestive endoscopy., Methods: During the period from 1981 to 1999, 500 patients with BES were treated and followed up at the Gastrocenter - UNICAMP, in an individually Program of Esophageal Dilatation for each case. The highest number of cases was under ages from 31 to 60 years old (52,8%), and males (59,2%). The most predominant etiologies were: peptic stenosis (30,4%), caustic ingestion (23,6%), anastomosis (23,2%), megaesophagus (8,0%) and prolonged nasogastric ingestion entubation (6,4%), totalizing 91,6% of the BES. Most of patients (94,2%) were submitted to the maximum of 25 dilations. Dilators from 10,5 to 16 mm were employed in 95,6% of the cases. The duration of the treatment was 24 months in 76,2% of the BES. Esophageal perforations occurred in 6 patients (1,2%), without mortality., Results: Were considered excellent, good and bad results, respectively in 76,2%, 18,2% and 5,6% of the cases. On the other hand, excellent results were recorded in 81,0% of the peptic stenosis, 66,1% of the caustic stenosis and 82,7% of the anastomotic stenosis. The conservative treatment failed in 9,3% of the caustic stenosis, 4,3% of the anastomotic stenosis and 3,9% of the peptic stenosis. Thus, the caustic stenosis were unsuccessfull in the highest percentage of unsuccessful., Conclusion: The conservative treatment using guidewire dilators (Savary-Gilliard and Eder-Puestow) is the first choice in the BES, is effective for long time, with short complications and the surgical treatment is indicated only when the dilatations failed.
Published: 2001
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32. [Videolaparoscopic surgical treatment of gastroesophageal reflux disease: modified Nissen technique - clinical and functional results].

Author: Lopes LR, Brandalise NA, Andreollo NA, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Laparoscopy methods, Male, Middle Aged, Prospective Studies, Treatment Outcome, Video-Assisted Surgery methods, Fundoplication methods, Gastroesophageal Reflux surgery
Abstract: Background: Gastroesophageal reflux disease is highly common worldwide and surgical treatment is being indicated more frequently. Currently, laparoscopic is the access of choice and several antireflux techniques may be used. We prefer a modified Nissen technique., Purpose: To analyze preoperative clinical and functional parameters and compare with postoperative outcome of a modified valve technique performed by laparoscopy., Methods: A group of 59 patients underwent laparoscopic modified Nissen valve. Preoperative diagnosis was made by radiological contrast exams and endoscopy in all patients. Esophagus manometry was performed in 35 patients and scintigraphy scan in 15 patients. Complicated esophagitis occurred in 54.2%, with 21 (35.6%) patients presenting a Barrett's epithelium. Laparoscopic surgery was performed in all patients with no conversion to open surgery, with an average time of 123.9 minutes., Results: There were no intraoperative complications. Hospital discharge occurred in an average of 47.6 hours. Symptoms as dysphagia, pain, regurgitation and flatus occurred in 48.1% of the patients in the first thirty days. Average follow-up was 20.8 months. Postoperative radiological, endoscopic, manometric and scintigrafic scan exams showed a significant improvement, as well as clinical assessment using Visick's classification, which showed excellent and good results in 93.1% of the patients., Conclusion: Comparative analysis of clinical assessment and exam results lad us to conclude that modified Nissen surgery by laparoscopic access corrects gastroesophageal reflux in most patients followed-up.
Published: 2001
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33. [Importance of upper digestive endoscopy using lugol dye solution for the diagnosis of superficial esophageal cancer and dysplasia in patients with head and neck neoplasms].

Author: Tincani AJ, Brandalise N, Andreollo NA, Lopes LR, Montes CG, Altemani A, and Martins AS
Subjects: Adult, Aged, Coloring Agents, Esophageal Diseases pathology, Esophageal Neoplasms pathology, Female, Humans, Male, Middle Aged, Prospective Studies, Sensitivity and Specificity, Staining and Labeling, Carcinoma, Squamous Cell diagnosis, Esophageal Neoplasms diagnosis, Esophagoscopy methods, Head and Neck Neoplasms, Neoplasms, Second Primary diagnosis
Abstract: Head and neck cancer has a high incidence in Brazil, with cancer of the oral cavity being one of the five most common cancers among Brazilians. Alcohol and tobacco consumption may contribute to synchronous or metachronous head and neck cancer and esophageal cancer. A prospective study involving 60 patients with head and neck cancer was carried out at the State University of Campinas--UNICAMP, Campinas, SP, Brazil to screen for superficial esophageal cancer and dysplasia using endoscopy and a 2% lugol dye solution followed by biopsy of the suspicious areas. Five patients (8.3%) had superficial esophageal cancer, which was diagnosed as intraepithelial carcinoma in three of them (5.0%). In four patients, the superficial esophageal cancer was synchronous and in one it was metachronous to head and neck cancer. Five patients (8.3%) had dysplasias in the esophageal epithelium (three were classified as mild and two as moderate). These results demonstrate the value of endoscopic screening of the esophagus using lugol dye in patients with head and neck cancer, particularly since superficial esophageal cancer is extremely difficult to detect by conventional methods in asymptomatic patients.
Published: 2000
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34. [Laparoscopy in the diagnosis of intra-abdominal diseases. Analysis of 168 cases].

Author: Andreollo NA, Coelho Neto Jde S, Lopes LR, Brandalise NA, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Child, Female, Humans, Male, Middle Aged, Gastrointestinal Diseases diagnosis, Laparoscopy methods
Abstract: Unlabelled: The laparoscopy has been more and more frequently indicated in the last years, for the complementary diagnosis of intraabdominal diseases and abdominal repercussion of systemic diseases. Modern equipaments including videolaparoscopy and the use of either forceps or biopsy needle permit higher safety and significant diagnostic capacity., Purpose: To perform laparoscopy for the diagnosis of intraabdominal and sistemic diseases., Methods: During the last 9 years 168 patients were submitted to laparoscopy and the main indications were: ascites--43 cases (25.5%); liver diseases--42 cases (25%); gastric cancer--37 cases (22%); lymphoma--17 cases (10.1%); abdominal tumour--9 cases (5.4%); peritoneal tuberculosis--8 cases (4.8%); liver tumour--6 cases (3.6%); mesenteric cyst--1 case (0.6%) and other diseases--5 cases (3.0%). Ninety nine patients were male (58.9%) aging from 9 to 78 years old (median 47.6 years). Liver biopsies were performed in 92 cases (54.7%) and other tumour biopsies in 26 cases (15.4%)., Results: The diagnosis of the diseases were established or confirmed by laparoscopy in 145 patients (86.3%). In 25 cases of gastric cancer (67.5%) laparoscopy contraindicated the laparotomy, owing to advanced disease. Two patients presented bleeding (1.2%) after liver biopsies and laparotomy was immediately indicated. One of them, whose diagnosis was systemic lupus, presented abdominal abscess, bronchopneumony and died (0.6%)., Conclusion: Laparoscopy has small number of complications, and when employed as a diagnostic complementary method therapeutic procedures, avoids laparotomies and accelerate therapeutic procedures.
Published: 1999
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35. [Incidence and epidemiology of Barrett's epithelium at the Gastrocentro-UNICAMP].

Author: Andreollo NA, Michelino MU, Brandalise NA, Lopes LR, Trevisan MA, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Aged, 80 and over, Brazil epidemiology, Child, Child, Preschool, Epithelium, Female, Gastroesophageal Reflux, Humans, Incidence, Male, Middle Aged, Barrett Esophagus epidemiology
Abstract: It is very important in the clinical practice to identify the individuals with Barrett's esophagus, because they are at risk to develop adenocarcinoma in the columnar epithelium. The objective of this research is to verify the incidence of this specific kind of epithelium at the "Gastrocentro", at State University of Campinas-UNICAMP, Campinas, SP, Brazil, among the total of 15,976 upper digestive endoscopies, performed from january of 1992 to December of 1995. From the total examinations performed were identified 2,381 patients (14.9%) presenting reflux esophagitis (grades I-IV, Savary-Miller). Among this group of patients, the endoscopist suspected of Barrett's esophagus in 110 cases (4.6%) and biopsed the distal esophagus. However, only in 85 cases (77.3%) the pathologist confirmed the diagnosis of Barrett's epithelium. The patients with Barrett's esophagus were 53 males (62.3%), presenting the mean age of 52.2 years and the following grades of esophagitis: grade I-33 cases (38.8%); grade II-15 cases (17.7%); grade III-15 cases (17.7%), grade IV-12 cases (14.1%) and without esophagitis-10 cases (11.7%). The incidence of Barrett's esophagus among the patients with reflux esophagitis was 3.57%, and among the total of examinations performed at the "Gastrocentro" during the period of four years was 0.53%, totalizing 22,4 cases/100,000 habitants.
Published: 1997

36. [Association of gastroduodenal mucosa lesions and varices as a cause of upper digestive hemorrhage. Retrospective study at a university hospital].

Author: Collaguazo PM, Andreollo NA, Lopes LR, dos Santos JO, Yamanaka A, Magalhães AF, and Brandalise NA
Subjects: Adolescent, Adult, Age Distribution, Aged, Duodenal Ulcer complications, Duodenal Ulcer diagnosis, Duodenitis complications, Duodenitis diagnosis, Endoscopy, Digestive System, Female, Gastritis complications, Gastritis diagnosis, Humans, Male, Middle Aged, Retrospective Studies, Sex Distribution, Stomach Ulcer complications, Stomach Ulcer diagnosis, Esophageal and Gastric Varices complications, Gastrointestinal Hemorrhage etiology, Hypertension, Portal complications
Abstract: During the period from August 1st, 1990 to June 15, 1992, 117 patients with portal hypertension and upper gastrointestinal bleeding were examined at the "GASTROCENTRO"--State University of Campinas--UNICAMP, Campinas, SP, Brazil few hours after hospital admission. The objectives were to study the association of gastroduodenal acute lesions and esophageal varices. The predominant ages were thirties and sixties years (83.76%), being 70.08% of males. The hematemesis occurred in 94.02% of the cases. The etiologies of the bleeding were: esophageal varices, 47.87%; gastroduodenal acute mucosal lesions, 34.19%; gastric varices, 9.4%; gastric ulcers, 5.98% and duodenal ulcers, 2.56%. The authors concluded that exists a significant association of acute gastroduodenal lesions and esophageal varices causing upper gastrointestinal bleeding. It is essential to examine early and in detail the gastroduodenal mucosa during upper digestive endoscopy in the patient with portal hypertension and esophageal varices to diagnose the etiology of the bleeding. It is advisable to perform endoscopic examination twice a year when the dyspeptic symptoms are constant, with previous treatment for gastroduodenal acute mucosal lesions or peptic ulcers, and annual in the others.
Published: 1993

37. [The gastroduodenal mucosa in patients with portal hypertension: correlation with blood gastrin].

Author: Andreollo NA, Lopes LR, Trevisan MA, Brandalise NA, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Analysis of Variance, Biopsy, Duodenum pathology, Endoscopy, Female, Humans, Hypertension, Portal blood, Male, Middle Aged, Prospective Studies, Prothrombin analysis, Pyloric Antrum pathology, Gastric Mucosa pathology, Gastrins blood, Hypertension, Portal pathology
Abstract: Purpose: gastroduodenal mucosa of two groups of patients with chronic liver disease was studied: schistosomotic mansoni patients (SH) and non-schistosomic patients (NSH). Results were compared to serum-gastrin levels. TYPE: prospective study., Place: Unicamp University Hospital (Hospital das Clínicas), Campinas, São Paulo, Brazil., Patients: 24 patients were included in the results, out of 26 patients studied. Two groups of study: 12 patients with schistosomiasis and liver fibrosis (SH), and 12 patients with liver cirrhosis (NSH) secondary to alcoholism or to hepatitis., Procedures: esophagogastroduodenoscopies and biopsies of gastric antrum and duodenum. Function tests of the liver were also studied., Results: results of gastrinemia were found within normal ranges in both groups. Student test ("t") did not show differences between groups at the 5% level. However, patients with chronic liver cirrhosis had more significant and severe endoscopic findings and chronic inflammatory processes of the gastroduodenal mucosa (acute gastritis, duodenitis and ulcers) than patients with liver fibrosis., Conclusions: patients with liver cirrhosis due to high risk of gastroduodenal bleeding should be maintained under continuous vigilance, appropriate diet and mucosa cytoprotectors. Furthermore, more research is required to study the etiology of gastroduodenal lesions in these specific groups of patients.
Published: 1991

38. [Incisional hernias: evaluation of the surgical treatment].

Author: Andreollo NA, Brandalise NA, Fagundes JJ, Mantovani M, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Anti-Bacterial Agents therapeutic use, Drainage, Humans, Middle Aged, Postoperative Care, Postoperative Complications, Suture Techniques, Hernia, Ventral surgery
Published: 1984

39. Motor responses of the upper esophageal sphincter and body to intraluminal acid.

Author: Andreollo NA, Thompson DG, Kendall GP, McIntyre AS, and Earlam RJ
Subjects: Adult, Humans, Male, Manometry, Peristalsis, Pressure, Esophagogastric Junction physiology, Esophagus physiology, Gastric Acid physiology
Abstract: 1. It is known that contraction of the upper esophageal sphincter (UES) and secondary peristalsis protect the airway and clear the esophagus of refluxed gastric contents. However, the exact nature of the stimulus and the role of acid remain controversial. 2. Secondary peristalsis and UES responses were measured following the intraluminal infusion of 0.1 N hydrochloric acid and equiosmolar NaCl solutions in seven normal volunteers. The protocol consisted of three phases: infusion of increasing volumes (1, 3, 5 and 7 ml per min), infusion of a given volume (7 ml per min) at different stimulation sites and balloon distension. 3. At the proximal esophagus the UES response to both solutions was similar, rising from a basal resting pressure of 30 mmHg to 70 mmHg for both HCl (range 60-85 mmHg) and NaCl (55-85 mmHg). The magnitude of the response decreased as the distance from the UES increased. The level of response decreased to 40 mmHg for both NaCl and HCl (range 30-60 mmHg) at the distal esophagus. These responses were also volume dependent. When the solutions were infused at 7 ml/min into either the proximal or distal esophagus, the sphincter pressure increased with increased volume to 65 mmHg for HCl (range 50-85 mmHg) and 60 mmHg for NaCl (range 50-80 mmHg). Secondary peristalsis was also induced by the two solutions. The level of response again decreased as the distance from the UES increased. This response was also volume dependent. Esophageal distension by a balloon positioned 10 cm below the sphincter induced secondary peristalsis and sphincter response identical to those induced by the infusion of fluid. 4. These results indicate that the principal stimulus for recruitment of the esophageal motor clearance mechanism is intraluminal distension and not necessarily the pressure of intraluminal acid.
Published: 1989

40. [Rupture of a pancreatic pseudocyst].

Author: Leonardi LS, Fagundes JJ, Andreollo NA, and Mantovani M
Subjects: Adult, Humans, Male, Pancreatic Pseudocyst surgery, Rupture, Spontaneous, Pancreatic Cyst diagnosis, Pancreatic Pseudocyst diagnosis
Published: 1982

41. Responses of the upper esophageal sphincter and esophageal body to graded intraluminal distension.

Author: Andreollo NA, Thompson DG, Kendall GP, and Earlam RJ
Subjects: Adult, Female, Humans, Male, Pressure, Catheterization, Esophagus physiology, Manometry
Abstract: 1. The responses of the upper esophageal sphincter (UES) to graded intraluminal distension of the esophagus were examined to determine response thresholds and to define the functional relationship between the sphincter and the esophageal body. 2. Nine normal subjects underwent manometric examination using a multiluminal tube with an attached inflatable balloon located 10 cm below the UES. Sphincter and esophageal motor responses to six balloon inflation volumes (1, 2, 4, 6, 8, and 10 ml) were recorded in each subject. 3. The UES responded to distension by increasing pressure, from a median value of 42.5 mmHg with a threshold distension of 1.0 cm, to 95 mmHg at 2.2 cm. Non-swallow-related, secondary contractile waves were stimulated in the esophageal body proximal to the distension and increased in number as inflation increased. Distal propagation of this secondary activity was inhibited with increasing distension. The amplitude of the primary peristalsis increased significantly to 61.7 mmHg at 2.2 cm. 4. These data demonstrate the normal upper esophageal motor responses to distension and provide a reference for future investigations of patients showing evidence of impaired esophageal clearance and in whom standard manometry may be unhelpful.
Published: 1987

42. [Incipient megaesophagus: dilatation or surgery?].

Author: Andreollo NA, Brandalise NA, and Leonardi LS
Subjects: Adolescent, Adult, Aged, Esophageal Achalasia diagnosis, Esophageal Achalasia surgery, Esophagogastric Junction physiopathology, Esophagoscopy, Esophagus diagnostic imaging, Female, Humans, Male, Manometry, Middle Aged, Radiography, Dilatation, Esophageal Achalasia therapy
Published: 1984

43. [Papillosphincteroplasty in the treatment of biliary duct calculi].

Author: Leonardi LS, Mantovani M, Brandalise NA, Fagundes JJ, and Andreollo NA
Subjects: Adult, Age Factors, Aged, Cholecystectomy, Female, Humans, Male, Middle Aged, Postoperative Complications, Sex Factors, Ampulla of Vater surgery, Cholelithiasis surgery, Gallstones surgery, Sphincter of Oddi surgery
Published: 1979

44. [Electrocauterization for hemostasis of the submucosa vessels in digestive tract surgery].

Author: Brandalise NA, Leonardi LS, Mantovani M, Costa LA, and Andreollo NA
Subjects: Gastrointestinal Diseases complications, Gastrointestinal Diseases surgery, Humans, Nutrition Disorders complications, Electrocoagulation, Gastrectomy, Gastric Mucosa surgery, Hemostasis, Surgical methods
Published: 1979

45. [Total gastrectomy: Lefèvre's technic].

Author: Leonardi LS, Brandalise NA, Mantovani M, and Andreollo NA
Subjects: Adenocarcinoma surgery, Humans, Stomach Neoplasms surgery, Gastrectomy methods
Published: 1981

46. [Evaluation of the surgical treatment of tumors of the extra-hepatic bile ducts and head of the pancreas].

Author: Brandalise NA, Leonardi LS, and Andreollo NA
Subjects: Adult, Aged, Bile Duct Neoplasms mortality, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms mortality, Postoperative Complications, Prognosis, Ampulla of Vater surgery, Bile Duct Neoplasms surgery, Common Bile Duct surgery, Pancreatic Neoplasms surgery
Published: 1980

47. [Use of proximal gastric vagotomy in the surgery of stenosing duodenal ulcer].

Author: Leonardi LS, Brandalise NA, Mantovani M, Fagundes JJ, and Andreollo NA
Subjects: Adolescent, Adult, Aged, Chronic Disease, Female, Humans, Male, Middle Aged, Pyloric Stenosis surgery, Duodenal Ulcer surgery, Vagotomy, Vagotomy, Proximal Gastric
Published: 1981

48. [Dilated choledochus: a dilemma for the surgeon].

Author: Leonardi LS, Brandalise NA, Mantovani M, Fagundes JJ, and Andreollo NA
Subjects: Adult, Aged, Drainage, Female, Humans, Ligation, Male, Middle Aged, Postoperative Complications, Gallstones surgery
Published: 1980

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