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1. Neuropsychiatric prodromes and symptom timings in relation to disease onset and/or flares in SLE: results from the mixed methods international INSPIRE study.

Author

Sloan, Melanie, Bourgeois, James, Leschziner, Guy, Pollak, Thomas, Pitkanen, Mervi, Harwood, Rupert, Bosley, Michael, Bortoluzzi, Alessandra, Andreoli, Laura, Diment, Wendy, Brimicombe, James, Ubhi, Mandeep, Barrere, Colette, Naughton, Felix, Gordon, Caroline, and DCruz, David

Subjects
Lupus, Mixed methods, Neuropsychiatric, Nightmares, Prodrome, SLE
Abstract

BACKGROUND: Neuropsychiatric symptoms in SLE and other systemic autoimmune rheumatic diseases (SARDs) are challenging to diagnose, attribute and manage. We investigated the timings of onset of a broad range of neuropsychiatric (NP) symptoms in relation to timing of SLE onset. In addition, we explored whether NP symptoms may be a prodrome to SARD onset and to subsequent flares. METHODS: We collected patient reports of the timing of their first episode of 29 NP symptoms relative to SLE non-NP symptom onset. Surveys (n = 676 SLE patients and n = 400 clinicians) and interviews (n = 50 clinicians; and n = 69 SARD patients, including 27 SLE patients) were completed from 2022 to 2023, and analysed using mixed methods. FINDINGS: The majority of NP symptoms did not first present around the time of SLE onset, contrary to the prevailing view among many rheumatology participants and in the literature. For example, among patients who experienced hallucinations, 54% reported first presentation >1 year after disease onset. Patient interviews also revealed that a range of NP symptoms may be a prodrome to SLE/SARDs onset and later flares, including symptoms not represented in existing classification criteria. Evidence of a possible prodromal syndrome was elicited from those patients who experienced hallucinations. Of these, 61% (SLE) and 34% (other SARDs) reported increasingly disrupted dreaming sleep (usually nightmares) prior to their hallucinations. In-depth interviews revealed that progression of symptoms in flares showed a high degree of inter-patient variation, whilst symptom progression was often similar in individual patients recurrent flares. INTERPRETATION: Neuropsychiatric symptoms can first present at any stage in the SLE disease course. Attributional decisions should evaluate timings of NP symptoms in relation to timing of SLE/SARD symptom onset rather than time of diagnosis due to frequent diagnostic delays. Greater recognition of prodromal/early NP symptoms indicating impending SLE flares (and potentially other SARD flares) could enable quicker flare identification and treatment. FUNDING: The Lupus Trust.

Published
2024

2. Correction to: Collating the voice of people with autoimmune diseases: Methodology for the third phase of the COVAD studies

Author

Kadam, Esha, Javaid, Mahnoor, Sen, Parikshit, Saha, Sreoshy, Ziade, Nelly, Day, Jessica, Wincup, Chris, Andreoli, Laura, Parodis, Ioannis, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Dey, Dzifa, Cavagna, Lorenzo, Chatterjee, Tulika, Knitza, Johannes, Wang, Guochun, Dalbeth, Nicola, Velikova, Tsvetelina, Battista, Simone, Cheng, Karen, Boyd, Peter, Kobert, Linda, Gracia-Ramos, Abraham Edgar, Mittal, Srijan, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Caballero-Uribe, Carlo V., Kuwana, Masataka, Burmester, Gerd-Rüdiger, Guillemin, Francis, Nikiphorou, Elena, Chinoy, Hector, Agarwal, Vikas, and Gupta, Latika

Published
2024
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3. Collating the voice of people with autoimmune diseases: Methodology for the Third Phase of the COVAD Studies

Author

Kadam, Esha, Javaid, Mahnoor, Sen, Parikshit, Saha, Sreoshy, Ziade, Nelly, Day, Jessica, Wincup, Chris, Andreoli, Laura, Parodis, Ioannis, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Dey, Dzifa, Cavagna, Lorenzo, Chatterjee, Tulika, Knitza, Johannes, Wang, Guochun, Dalbeth, Nicola, Velikova, Tsvetelina, Battista, Simone, Cheng, Karen, Boyd, Peter, Kobert, Linda, Gracia-Ramos, Abraham Edgar, Mittal, Srijan, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Uribe, Carlo V Caballero, Kuwana, Masataka, Burmester, Gerd-Rüdiger, Guillemin, Francis, Nikiphorou, Elena, Chinoy, Hector, Aggarwal, Vikas, and Gupta, Latika

Published
2024
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4. Author Correction: Regulation of neutrophil associated RNASET2 expression in rheumatoid arthritis

Author

Passari, Mauro, Scutera, Sara, Schioppa, Tiziana, Tiberio, Laura, Piantoni, Silvia, Tamassia, Nicola, Bugatti, Mattia, Vermi, William, Angeli, Fabrizio, Caproli, Alessia, Salvi, Valentina, Sozio, Francesca, Gismondi, Angela, Stabile, Helena, Franceschini, Franco, Bosisio, Daniela, Acquati, Francesco, Vermeren, Sonja, Sozzani, Silvano, Andreoli, Laura, Del Prete, Annalisa, and Musso, Tiziana

Published
2024
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5. Regulation of neutrophil associated RNASET2 expression in rheumatoid arthritis

Author

Passari, Mauro, Scutera, Sara, Schioppa, Tiziana, Tiberio, Laura, Piantoni, Silvia, Tamassia, Nicola, Bugatti, Mattia, Vermi, William, Angeli, Fabrizio, Caproli, Alessia, Salvi, Valentina, Sozio, Francesca, Gismondi, Angela, Stabile, Helena, Franceschini, Franco, Bosisio, Daniela, Acquati, Francesco, Vermeren, Sonja, Sozzani, Silvano, Andreoli, Laura, Del Prete, Annalisa, and Musso, Tiziana

Published
2024
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6. Overview on CTD in the Elderly

Author

Lini, Daniele, Semeraro, Paolo, Fredi, Micaela, Campana, Andrea, Gozzoli, Giorgia, Piovani, Elda, Andreoli, Laura, Franceschini, Franco, Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima Tatiana, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, and Vaglio, Augusto, Editorial Board Member

Published
2024
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13. Complement levels during the first trimester predict disease flare and adverse pregnancy outcomes in systemic lupus erythematosus: A network meta-analysis on 532 pregnancies

Author

Radin, Massimo, Cecchi, Irene, Crisafulli, Francesca, Klumb, Evandro Mendes, de Jesús, Guilherme Ramires, Lacerda, Marcela Ignacchiti, Saavedra, Miguel Ángel, Reyes-Navarro, Geraldine Vanessa, Iaccarino, Luca, Larosa, Maddalena, Moroni, Gabriella, Tamborini, Francesco, Roccatello, Dario, Andreoli, Laura, Sciascia, Savino, and Chighizola, Cecilia Beatrice

Published
2023
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15. Associations Among Antiphospholipid Antibody Types, Isotypes, and Titers: An AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Study

Author

Pons-Estel, Guillermo, Giannakopoulos, Bill, Krilis, Steve, de Jesus, Guilherme, Levy, Roger, Signorelli, Flavio, Andrade, Danieli, Balbi, Gustavo, Clarke, Ann E., Skeith, Leslie, Fortin, Paul R., Ji, Lanlan, Zhang, Zhouli, Yang, Chengde, Shi, Hui, Zuily, Stephane, Wahl, Denis, Tektonidou, Maria G., Nalli, Cecilia, Andreoli, Laura, Tincani, Angela, Chighizola, Cecilia B., Gerosa, Maria, Meroni, Pierluigi, Pengo, Vittorio, Cheng, Chunyan, Pazzola, Giulia, Sciascia, Savino, Foddai, Silvia, Radin, Massimo, Davis, Stacy, Amengual, Olga, Atsumi, Tatsuya, Uthman, Imad, Limper, Maarten, Groot, Philip de, Ruiz—Irastorza, Guillermo, Ugarte, Amaia, Rodriguez-Pinto, Ignasi, Cervera, Ricard, Pardos-Gea, Jose, Rodriguez Almaraz, Esther, Cuadrado, Maria Jose, Aguirre Zamorano, Maria Angeles, Lopez-Pedrera, Chary, Artim-Esen, Bahar, Inanc, Murat, Bertolaccini, Maria Laura, Cohen, Hannah, Efthymiou, Maria, Khamashta, Munther, Mackie, Ian, Sanna, Giovanni, Knight, Jason, Zuo, Yu, Petri, Michelle, Leaf, Rebecca K., Roubey, Robert, Ortel, Thomas, Gonzalez, Emilio, Willis, Rohan, Kello, Nina, Belmont, Michael, Levine, Steven, Rand, Jacob, Barbhaiya, Medha, Erkan, Doruk, Salmon, Jane, Lockshin, Michael, Duarte Garcia, Ali A., Branch, D. Ware, Gkrouzman, Elena, Ruiz-Irastorza, Guillermo, Belmont, H. Michael, Rodriguez-Almaraz, Esther, Petri, Michelle A., and Knight, Jason S.

Published
2023
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17. List of contributors

Author

Adiguzel, Yekbun, primary, Andreoli, Laura, additional, Antonelli, Eleonora, additional, Athanassiou, Lambros, additional, Athanassiou, Panagiotis, additional, Avčin, Tadej, additional, Babel, Nina, additional, Bechmann, Nicole, additional, Benzvi, Carina, additional, Bitsadze, Victoria, additional, Bogdanos, Dimitrios P., additional, Bonam, Srinivsasa Reddy, additional, Borba, Vânia, additional, Borghi, M.O., additional, Bornstein, Stefan R., additional, Bragazzi, Nicola Luigi, additional, Carrera-Bastos, Pedro, additional, Churilov, Leonid P., additional, Crisafulli, Francesca, additional, Cruz-Domínguez, María Pilar, additional, Cugno, M., additional, Danieli, MariaGiovanna, additional, Dardiotis, Efthymios, additional, David, Paula, additional, Davidy, Tal, additional, Della-Pina, Silvia-Ebe-Lucia, additional, Dotan, Arad, additional, Dragon-Durey, Marie-Agnès, additional, Efthymiou, Georgios, additional, Ehrenfeld, Michael, additional, Elalamy, Ismail, additional, Emeršič, Nina, additional, Evelina, Kamaeva, additional, Fontana, Giulia, additional, Franceschini, Franco, additional, Fremeaux-Bacchi, Véronique, additional, Fritzler, Marvin J., additional, Galaviz-Sánchez, Maria F., additional, Ganina, K.K., additional, Gavrilova, Natalia, additional, Giacomelli, Roberto, additional, Gris, Jean-Christophe, additional, Gutierrez-Melgarejo, Caroline I., additional, Horwitz, Ehud, additional, Israeli, Eitan, additional, Jacotot, Etienne, additional, Jara, Luis J., additional, Kanduc, Darja, additional, Kessel, Christoph, additional, Khizroeva, Jamilya, additional, Kolobov, Andrei, additional, Kostoglou-Athanassiou, Ifigenia, additional, Lapin, Sergey V., additional, Lasagni, G., additional, Lerner, Aaron, additional, Lev, Danielle Zemer, additional, Lidiia, Soprun, additional, López-Zamora, Berenice, additional, Lozano, Jose Manuel, additional, Lucas Hernández, Abihai, additional, Makatsariya, Alexander, additional, Malkova, Anna, additional, Maria, Lukashenko, additional, Mayorova, Margarita A., additional, Medina, Gabriela, additional, Meroni, P.L., additional, Mevorach, Dror, additional, Muller, Sylviane, additional, N. Petrova, Natalia, additional, Nikolenko, Vladimir N., additional, Ordinola Navarro, Alberto, additional, Ordoñez-González, Irvin, additional, Paladini, Alberto, additional, Pervakova, Margarita Y., additional, Perzon, Ofer, additional, Petrova, N.V., additional, Radic, Marko, additional, Rigopoulou, Eirini I., additional, Rodrigues-Fernandes, Jorge-Manuel, additional, Rosenberg, Avi, additional, Ruscitti, Piero, additional, Ryabkova, Varvara A., additional, Saia, Rafael Simone, additional, Sankov, Sergey V., additional, Sankova, Maria V., additional, Shoenfeld, Yehuda, additional, Sinelnikov, Mikhail Y., additional, Sobolevskaia, Polina, additional, Stervbo, Ulrik, additional, Talamini, Laura, additional, Tarasov, S.A., additional, Thurner, Lorenz, additional, Tincani, Angela, additional, Tkachenko, Olga Y., additional, Tocut, M., additional, Ursini, Francesco, additional, Vera-Lastra, Olga, additional, Vieira, Angelica Thomaz, additional, Vojdani, Aristo, additional, Vojdani, Elroy, additional, Watad, Abdulla, additional, Zandman-Goddard, G., additional, Zmira, Ofir, additional, and Zohar, Daniela Noa, additional

Published
2023
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18. Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases

Author

Andreoli, Laura, Chighizola, Cecilia B., Iaccarino, Luca, Botta, Angela, Gerosa, Maria, Ramoni, Véronique, Tani, Chiara, Bermas, Bonnie, Brucato, Antonio, Buyon, Jill, Cetin, Irene, Chambers, Christina D., Clowse, Megan E.B., Costedoat-Chalumeau, Nathalie, Cutolo, Maurizio, De Carolis, Sara, Dolhain, Radboud, Fazzi, Elisa M., Förger, Frauke, Giles, Ian, Haase, Isabell, Khamashta, Munther, Levy, Roger A., Meroni, Pier Luigi, Mosca, Marta, Nelson-Piercy, Catherine, Raio, Luigi, Salmon, Jane, Villiger, Peter, Wahren-Herlenius, Marie, Wallenius, Marianne, Zanardini, Cristina, Shoenfeld, Yehuda, and Tincani, Angela

Published
2023
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19. Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

Author

Andreoli, Laura, Nalli, Cecilia, Lazzaroni, Maria Grazia, Carini, Chiara, Dall’Ara, Francesca, Reggia, Rossella, Rodrigues, Marília, Benigno, Carolina, Baldissera, Elena, Bartoloni, Elena, Basta, Fabio, Bellisai, Francesca, Bortoluzzi, Alessandra, Campochiaro, Corrado, Cantatore, Francesco Paolo, Caporali, Roberto, Ceribelli, Angela, Chighizola, Cecilia B., Conigliaro, Paola, Corrado, Addolorata, Cutolo, Maurizio, D’Angelo, Salvatore, De Stefani, Elena, Doria, Andrea, Favaro, Maria, Fischetti, Colomba, Foti, Rosario, Gabrielli, Armando, Generali, Elena, Gerli, Roberto, Gerosa, Maria, Larosa, Maddalena, Maier, Armin, Malavolta, Nazzarena, Meroni, Marianna, Meroni, Pier Luigi, Montecucco, Carlomaurizio, Mosca, Marta, Padovan, Melissa, Paolazzi, Giuseppe, Pazzola, Giulia, Peccatori, Susanna, Perricone, Roberto, Pettiti, Giorgio, Picerno, Valentina, Prevete, Immacolata, Ramoni, Véronique, Romeo, Nicoletta, Ruffatti, Amelia, Salvarani, Carlo, Sebastiani, Gian Domenico, Selmi, Carlo, Serale, Francesca, Sinigaglia, Luigi, Tani, Chiara, Trevisani, Marica, Vadacca, Marta, Valentini, Eleonora, Valesini, Guido, Visalli, Elisa, Vivaldelli, Ester, Zuliani, Lucia, and Tincani, Angela

Published
2022
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20. Attribution of neuropsychiatric symptoms and prioritization of evidence in the diagnosis of neuropsychiatric lupus: mixed methods analysis of patient and clinician perspectives from the international INSPIRE study.

Author

Sloan, Melanie, Andreoli, Laura, Zandi, Michael S, Harwood, Rupert, Pitkanen, Mervi, Sloan, Sam, Barrere, Colette, Massou, Efthalia, Wincup, Chris, Bosley, Michael, Naughton, Felix, Ubhi, Mandeep, Jayne, David, Leschziner, Guy, Brimicombe, James, Diment, Wendy, Middleton, Kate, Gordon, Caroline, D'Cruz, David, and Pollak, Thomas A

Subjects
*SYSTEMIC lupus erythematosus diagnosis, *SELF-evaluation, *DISEASE duration, *RESEARCH funding, *INTERVIEWING, *SYSTEMIC lupus erythematosus, *DESCRIPTIVE statistics, *UNCERTAINTY, *SURVEYS, *THEMATIC analysis, *ATTITUDES of medical personnel, *COMPARATIVE studies, *PATIENTS' attitudes, *SYMPTOMS
Abstract

Objective Neuropsychiatric lupus (NPSLE) is challenging to diagnose. Many neuropsychiatric symptoms, such as headache and hallucinations, cannot be verified by tests or clinician assessment. We investigated prioritizations of methods for diagnosing NPSLE and attributional views. Methods Thematic and comparative analyses were used to investigate how clinicians prioritize sources of evidence from a 13-item list, and explore discordances in clinician (surveys n  = 400, interviews n  = 50) and patient (surveys n  = 676, interviews n  = 27) perspectives on attribution. Results We identified high levels of variability and uncertainty in clinicians' assessments of neuropsychiatric symptoms in SLE patients. In attributional decisions, clinicians ranked clinicians' assessments above diagnostic tests (many of which they reported were often unenlightening in NPSLE). Clinicians ranked patient opinion of disease activity last, and 46% of patients reported never/rarely having been asked if their SLE was flaring, despite experienced patients often having 'attributional insight'. SLE patients estimated higher attributability of neuropsychiatric symptoms to the direct effects of SLE on the nervous system than clinicians (P  < 0.001 for all symptoms excluding mania), and 24% reported that their self-assessment of disease activity was never/rarely concordant with their clinicians. Reports of misattributions were common, particularly of non-verifiable diffuse symptoms. Terminology differed between clinicians and influenced attribution estimates. Conclusion NPSLE diagnostic tests and clinician assessments have numerous limitations, particularly in detecting diffuse neuropsychiatric symptoms that can be directly attributable and benefit from immunosuppression. Our findings suggest that incorporating patient attributional insights—although also subject to limitations—may improve attribution decision-making. Consensus regarding terminology and interpretations of 'direct attributability' is required. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Durable renal response and safety with add-on belimumab in patients with lupus nephritis in real-life setting (BeRLiSS-LN). Results from a large, nationwide, multicentric cohort

Author

Gatto, Mariele, Saccon, Francesca, Andreoli, Laura, Bartoloni, Elena, Benvenuti, Francesco, Bortoluzzi, Alessandra, Bozzolo, Enrica, Brunetta, Enrico, Canti, Valentina, Cardinaletti, Paolo, Ceccarelli, Fulvia, Ciccia, Francesco, Conti, Fabrizio, De Marchi, Ginevra, de Paulis, Amato, De Vita, Salvatore, Emmi, Giacomo, Faggioli, Paola, Fasano, Serena, Fredi, Micaela, Gabrielli, Armando, Gasparotto, Michela, Gerli, Roberto, Gerosa, Maria, Govoni, Marcello, Gremese, Elisa, Laria, Antonella, Larosa, Maddalena, Mosca, Marta, Orsolini, Giovanni, Pazzola, Giulia, Petricca, Luca, Ramirez, Giuseppe A., Regola, Francesca, Rossi, Francesca W., Rossini, Maurizio, Salvarani, Carlo, Scarpato, Salvatore, Tani, Chiara, Tincani, Angela, Ubiali, Tania, Urban, Maria Letizia, Zen, Margherita, Doria, Andrea, and Iaccarino, Luca

Published
2021
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27. The outcomes of children born to mothers with autoimmune rheumatic diseases

Author

Immuno/reuma ERN, Andreoli, Laura, Andersen, Jeanette, Avcin, Tadej, Chambers, Christina D., Fazzi, Elisa M., Marlow, Neil, Wulffraat, Nico M., Tincani, Angela, Immuno/reuma ERN, Andreoli, Laura, Andersen, Jeanette, Avcin, Tadej, Chambers, Christina D., Fazzi, Elisa M., Marlow, Neil, Wulffraat, Nico M., and Tincani, Angela

Published
2024

28. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospective Italian P-RHEUM.it study

Author

Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Tincani, Angela, Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, and Tincani, Angela

Abstract

Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. Results We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19.6%). Maternal disease flares were observed in 135 (15.6%) pregnancies. 53 (6.1%) pregnancies were induced by assisted reproduction techniques, 61 (7%) ended in miscarriage and 11 (1.3%) underwent elective termination. Obstetrical complications occurred in 261 (30.1%) pregnancies, including 2.3% pre-eclampsia. Two cases of congenital heart block were observed out of 157 pregnancies (1.3%) with anti-Ro/SSA. Regarding treatments, 244 (28.2%) pregnancies were treated with glucocorticoids, 388 (44.8%) with hydroxychloroquine, 85 (9.8%) with conventional synthetic disease-modifying anti-rheumatic drugs and 122 (14.1%) with biological disease-modifying anti-rheumatic drugs. Live births were 794 (91.7%), mostly at term (84.9%); four perinatal deaths (0.5%) occurred. Among 790 newborns, 31 (3.9%) were small-for-gestational-age and 169 (21.4%) had perinatal complications. Exclusive maternal breast feeding was received by 404 (46.7%) neonates. The Edinburgh Postnatal Depression Scale was compiled by 414 women (52.4%); 89 (21.5%) scored positive for emotional distress. Conclusions Multiple factors including preconception counselling and treat-to-target with pregnancy-compatible medications may have contributed to mitigate disease-related risk factors, yielding limited disease flares, good pregnancy outcomes and frequency of complications which were similar to the Italian general obstetric population. Disease-specific issues need to be further addressed to plan preventative measures.

Published
2024

29. COVID-19 vaccine safety during pregnancy and breastfeeding in women with autoimmune diseases : results from the COVAD study

Author

Andreoli, Laura, Parodis, Ioannis, Gupta, Latika, Andreoli, Laura, Parodis, Ioannis, and Gupta, Latika

Abstract

OBJECTIVES: We investigated COVID-19 vaccine safety in pregnant and breastfeeding women with autoimmune diseases (AID) in the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. METHODS: Delayed-onset (>7 days) vaccine-related adverse events (AE), disease flares (DF), and AID-related treatment modifications were analyzed upon diagnosis of AID versus healthy controls (HC) and the pregnancy/breastfeeding status at the time of at least one dose of vaccine. RESULTS: Among the 9201 participants to the self-administered online survey, 6787 (73.8%) were women. Forty pregnant and 52 breastfeeding patients with AID were identified, of whom the majority had received at least one dose of COVID-19 vaccine (100% and 96.2%, respectively). AE were reported significantly more frequently in pregnant than in non-pregnant patients (overall AE 45% vs 26%, p= 0.01; minor AE 40% vs 25.9%, p= 0.03; major AE 17.5% vs 4.6%, p< 0.01), but no difference was found in comparison with pregnant HC. No difference was observed between breastfeeding patients and HC with respect to AE. Post-vaccination DF were reported by 17.5% of pregnant and 20% of breastfeeding patients, and by 18.3% of age- and disease-matched non-pregnant and non-breastfeeding patients (n = 262). All pregnant/breastfeeding patients who experienced a DF were managed with glucocorticoids; 28.6% and 20% of them required initiation or change in immunosuppressants, respectively. CONCLUSION: This study provides reassuring insights into the safety of COVID-19 vaccines administered to women with AID during the gestational and post-partum periods, helping overcome hesitant attitudes, as the benefits for the mother and the fetus by passive immunization appear to outweigh potential risks., Funding agency:National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre NIHR203308

Published
2024
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30. Listening to patients, for the patients : The COVAD Study-Vision, organizational structure, and challenges

Author

Joshi, Mrudula, Darooka, Naitica, Saha, Sreoshy, Dyball, Sarah, Sen, Parikshit, Yaadav, Praggya, Javaid, Mahnoor, Kadam, Esha, Shinjo, Samuel Katsuyuki, Dey, Dzifa, Cavagna, Lorenzo, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Caballero Uribe, Carlo V., Kuwana, Masataka, Burmester, Gerd-Ruediger, Ziade, Nelly, Wincup, Chris, Andreoli, Laura, Parodis, Ioannis, Tan, Ai Lyn, Guillemin, Francis, Knitza, Johannes, Wang, Guochun, Dalbeth, Nicola, Velikova, Tsvetelina, Gracia-Ramos, Abraham Edgar, Nikiphorou, Elena, Day, Jessica, Chinoy, Hector, Aggarwal, Rohit, Agarwal, Vikas, Gupta, Latika, Joshi, Mrudula, Darooka, Naitica, Saha, Sreoshy, Dyball, Sarah, Sen, Parikshit, Yaadav, Praggya, Javaid, Mahnoor, Kadam, Esha, Shinjo, Samuel Katsuyuki, Dey, Dzifa, Cavagna, Lorenzo, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Caballero Uribe, Carlo V., Kuwana, Masataka, Burmester, Gerd-Ruediger, Ziade, Nelly, Wincup, Chris, Andreoli, Laura, Parodis, Ioannis, Tan, Ai Lyn, Guillemin, Francis, Knitza, Johannes, Wang, Guochun, Dalbeth, Nicola, Velikova, Tsvetelina, Gracia-Ramos, Abraham Edgar, Nikiphorou, Elena, Day, Jessica, Chinoy, Hector, Aggarwal, Rohit, Agarwal, Vikas, and Gupta, Latika

Abstract

Background: The pandemic presented unique challenges for individuals with autoimmune and rheumatic diseases (AIRDs) due to their underlying condition, the effects of immunosuppressive treatments, and increased vaccine hesitancy. Objectives: The COVID-19 vaccination in autoimmune diseases (COVAD) study, a series of ongoing, patient self-reported surveys were conceived with the vision of being a unique tool to gather patient perspectives on AIRDs. It involved a multinational, multicenter collaborative effort amidst a global lockdown. Methods: Leveraging social media as a research tool, COVAD collected data using validated patient-reported outcomes (PROs). The study, comprising a core team, steering committee, and global collaborators, facilitated data collection and analysis. A pilot-tested, validated survey, featuring questions regarding COVID-19 infection, vaccination and outcomes, patient demographics, and PROs was circulated to patients with AIRDs and healthy controls (HCs). Discussion: We present the challenges encountered during this international collaborative project, including coordination, data management, funding constraints, language barriers, and authorship concerns, while highlighting the measures taken to address them. Conclusion: Collaborative virtual models offer a dynamic new frontier in medical research and are vital to studying rare diseases. The COVAD study demonstrates the potential of online platforms for conducting large-scale, patient-focused research and underscores the importance of integrating patient perspective into clinical care. Care of patients is our central motivation, and it is essential to recognize their voices as equal stakeholders and valued partners in the study of the conditions that affect them.

Published
2024
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33. Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus: A multi-center observational study

Author

Yavuz, Sule, Cansu, Dondu U, Nikolopoulos, Dionysis, Crisafulli, Francesca, Antunes, Ana M, Adamichou, Christina, Reid, Sarah, Stagnaro, Chiara, Andreoli, Laura, Tincani, Angela, Moraes-Fontes, Maria Francisca, Mosca, Marta, Leonard, Dag, Jönsen, Andreas, Bengtsson, Anders, Svenungsson, Elisabet, Gunnarsson, Iva, Dahlqvist, Solbritt Rantapää, Sjöwall, Christopher, Bertsias, George, Fanouriakis, Antonis, and Rönnblom, Lars

Published
2020
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34. COVID-19 in patients with rheumatic diseases in northern Italy: a single-centre observational and case–control study

Author

Airò, Paolo, Bazzani, Chiara, Crisafulli, Francesca, Filippini, Matteo, Frassi, Micol, Gerardi, Maria Chiara, Gorla, Roberto, Lazzaroni, Maria Grazia, Lini, Daniele, Nalli, Cecilia, Panaro, Salvatore, Piantoni, Silvia, Regola, Francesca, Taglietti, Marco, Tincani, Angela, Toniati, Paola, Vojinovic, Tamara, Zingarelli, Stefania, Fredi, Micaela, Cavazzana, Ilaria, Moschetti, Liala, Andreoli, Laura, and Franceschini, Franco

Published
2020
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36. In utero exposure to Azathioprine in autoimmune disease. Where do we stand?

Author

Belizna, Cristina, Meroni, Pier Luigi, Shoenfeld, Yehuda, Devreese, Katrien, Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Chighizola, Cecilia, Pregnolato, Francesca, Cohen, Hannah, Fassot, Celine, Mattera, Patrick Martin, Peretti, Pascale, Levy, Alexandre, Bernard, Laurence, Saiet, Mathilde, Lagarce, Laurence, Briet, Marie, Rivière, Marianne, Pellier, Isabelle, Gascoin, Géraldine, Rakotonjanahary, Jose, Borghi, Maria Orietta, Stojanovich, Ljudmila, Djokovic, Aleksandra, Stanisavljevic, Natasa, Bromley, Rebecca, Elefant-Amoura, Elisabeth, Bahi Buisson, Nadia, Pindi Sala, Taylor, Kelchtermans, Hilde, Makatsariya, Alexander, Bidsatze, Viktoria, Khizroeva, Jamilya, Latino, Jose Omar, Udry, Sebastian, Henrion, Daniel, Loufrani, Laurent, Guihot, Anne Laure, Muchardt, Christian, Hasan, Milena, Ungeheuer, Marie Noelle, Voswinkel, Jan, Damian, Laura, Pabinger, Ingrid, Gebhart, Johanna, Lopez Pedrera, Rosario, Cohen Tervaert, Jan Willem, Tincani, Angela, and Andreoli, Laura

Published
2020
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37. Covid-19 and autoimmunity

Author

Ehrenfeld, Michael, Tincani, Angela, Andreoli, Laura, Cattalini, Marco, Greenbaum, Assaf, Kanduc, Darja, Alijotas-Reig, Jaume, Zinserling, Vsevolod, Semenova, Natalia, Amital, Howard, and Shoenfeld, Yehuda

Published
2020
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39. Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy

Author

Toniati, Paola, Piva, Simone, Cattalini, Marco, Garrafa, Emirena, Regola, Francesca, Castelli, Francesco, Franceschini, Franco, Airò, Paolo, Bazzani, Chiara, Beindorf, Eva-Andrea, Berlendis, Marialma, Bezzi, Michela, Bossini, Nicola, Castellano, Maurizio, Cattaneo, Sergio, Cavazzana, Ilaria, Contessi, Giovanni-Battista, Crippa, Massimo, Delbarba, Andrea, De Peri, Elena, Faletti, Angela, Filippini, Matteo, Frassi, Micol, Gaggiotti, Mario, Gorla, Roberto, Lanspa, Michael, Lorenzotti, Silvia, Marino, Rosa, Maroldi, Roberto, Metra, Marco, Matteelli, Alberto, Modina, Denise, Moioli, Giovanni, Montani, Giovanni, Muiesan, Maria-Lorenza, Odolini, Silvia, Peli, Elena, Pesenti, Silvia, Pezzoli, Maria-Chiara, Pirola, Ilenia, Pozzi, Alessandro, Proto, Alessandro, Rasulo, Francesco-Antonio, Renisi, Giulia, Ricci, Chiara, Rizzoni, Damiano, Romanelli, Giuseppe, Rossi, Mara, Salvetti, Massimo, Scolari, Francesco, Signorini, Liana, Taglietti, Marco, Tomasoni, Gabriele, Tomasoni, Lina-Rachele, Turla, Fabio, Valsecchi, Alberto, Zani, Davide, Zuccalà, Francesco, Zunica, Fiammetta, Focà, Emanuele, Andreoli, Laura, and Latronico, Nicola

Published
2020
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43. P138 Pregnancy outcomes in SLE patients treated with belimumab: the Italian experience

Author

Crisafulli, Francesca, primary, Gerardi, Maria Chiara, additional, Urban, Maria Letizia, additional, Zen, Margherita, additional, Padovan, Melissa, additional, Canti, Valentina, additional, Praino, Emanuela, additional, Gerosa, Maria, additional, Nalli, Cecilia, additional, Ruffilli, Francesca, additional, Saccon, Francesca, additional, Fredi, Micaela, additional, Emmi, Giacomo, additional, Iaccarino, Luca, additional, Doria, Andrea, additional, Santo, Leonardo, additional, Franceschini, Franco, additional, Andreoli, Laura, additional, and Tincani, Angela, additional

Published
2024
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45. Neurodevelopmental profile in children born to mothers affected by systemic sclerosis

Author

Galli, Jessica, primary, Loi, Erika, additional, Lazzaroni, Maria Grazia, additional, Molinaro, Anna, additional, Andreoli, Laura, additional, Bendoni, Marzia, additional, Moschetti, Liala, additional, Pedretti, Eleonora, additional, Visconti, Lucrezia Maria, additional, Franceschini, Franco, additional, Tincani, Angela, additional, and Fazzi, Elisa, additional

Published
2024
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46. P135 Altered hemostatic balance towards procoagulant state in pregnant women with systemic lupus erythematosus

Author

Lini, Daniele, primary, Gunnarsson, Iva, additional, Soutari, Nida, additional, Lalic-Cosic, Sanja, additional, Nicholas, Andrea MC, additional, Chaireti, Roza, additional, Bremme, Katarina, additional, Franceschini, Franco, additional, Svenungsson, Elisabet, additional, Andreoli, Laura, additional, and Antovic, Aleksandra, additional

Published
2024
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47. Pregnancy in antiphospholipid syndrome: what should a rheumatologist know?

Author

Andreoli, Laura, primary, Regola, Francesca, additional, Caproli, Alessia, additional, Crisafulli, Francesca, additional, Fredi, Micaela, additional, Lazzaroni, Maria-Grazia, additional, Nalli, Cecilia, additional, Piantoni, Silvia, additional, Zatti, Sonia, additional, Franceschini, Franco, additional, and Tincani, Angela, additional

Published
2024
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49. Disease course and obstetric outcomes of pregnancies in juvenile idiopathic arthritis: are there any differences among disease subtypes? A single-centre retrospective study of prospectively followed pregnancies in a dedicated pregnancy clinic

Author

García-Fernández, Antía, Gerardi, Maria Chiara, Crisafulli, Francesca, Filippini, Matteo, Fredi, Micaela, Gorla, Roberto, Lazzaroni, Maria Grazia, Lojacono, Andrea, Nalli, Cecilia, Ramazzotto, Francesca, Taglietti, Marco, Zanardini, Cristina, Zatti, Sonia, Franceschini, Franco, Tincani, Angela, and Andreoli, Laura

Published
2021
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50. Setting the bar differently: how to navigate old and new sets of criteria for the classification of antiphospholipid syndrome.

Author

Tincani, Angela and Andreoli, Laura

Subjects
*CARDIOVASCULAR diseases, *VEINS, *ENZYME-linked immunosorbent assay, *THROMBOCYTOPENIA, *THROMBOEMBOLISM, *ANTIPHOSPHOLIPID syndrome
Abstract

The authors discuss research which focused on the 2023 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) classification criteria for antiphospholipid syndrome (APS), conducted by S. G. Foddai and colleagues. Topics explored include the creation of domains to arrange the clinical and laboratory features of APS, the patient risk scoring system introduced, and a comparison between the 2023 ACR/EULAR criteria and 2019 EULAR recommendations.

Published
2024
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