21 results on '"Andreis, DT"'
Search Results
2. Beta-blockade in experimental fluid-resuscitated sepsis: acute haemodynamic effects of esmolol differ in predicted survivors and non-survivors
- Author
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Khaliq, W, Andreis, DT, and Singer, M
- Published
- 2015
- Full Text
- View/download PDF
3. Tissue and plasma putrescine levels in non-survivors of sepsis in a fluid-resuscitated rat model of faecal peritonitis
- Author
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Andreis, DT, Khaliq, W, Neugebauer, S, Kiehntopf, M, and Singer, M
- Published
- 2015
- Full Text
- View/download PDF
4. Reductions in tyrosine levels are associated with thyroid hormone and catecholamine disturbances in sepsis
- Author
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Khaliq, W, Andreis, DT, Kleyman, A, Gräler, M, and Singer, M
- Published
- 2015
- Full Text
- View/download PDF
5. Sepsis results in early cholesterol and steroidogenesis pathway alterations
- Author
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Khaliq, W, Andreis, DT, and Singer, M
- Published
- 2015
- Full Text
- View/download PDF
6. Acute haemodynamic effects of dobutamine in experimental sepsis-induced myocardial depression
- Author
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Andreis, DT, Khaliq, W, and Singer, M
- Published
- 2015
- Full Text
- View/download PDF
7. Effect of tidal volume and positive end-expiratory pressure on lung hysteresis of healthy piglets
- Author
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Andreis, DT, Milesi, M, Pugni, P, Nicosia, F, lapichino, GE, Monti, M, Comini, B, Votta, E, Protti, A, and Gattinoni, L
- Published
- 2014
- Full Text
- View/download PDF
8. 0990. Role of amplitude and rate of deformation in ventilator-induced lung injury
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Protti, A, Andreis, DT, Milesi, M, Pugni, P, Nicosia, F, Maraffi, T, Melis, V, Monti, M, Votta, E, and Gattinoni, L
- Published
- 2014
- Full Text
- View/download PDF
9. ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016
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Sivakumar, S, Taccone, FS, Desai, KA, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Ilia, S, Henderson, A, Hugill, K, Howard, P, Roy, A, Bonner, S, Monteiro, E, Baudouin, S, Ramírez, CS, Escalada, SH, Banaszewski, M, Sertedaki, A, Kaymak, Ç, Viera, MA, Santana, MC, Balcázar, LC, Monroy, NS, Campelo, FA, Vázquez, CF, Santana, PS, Cerejo, A, Santana, SR, Charmadari, E, Carteron, L, Kovach, L, Patet, C, Quintard, H, Solari, D, Bouzat, P, Oddo, M, Wollersheim, T, Malleike, J, Haas, K, Stratakis, CA, Rocha, AP, Carbon, N, Şencan, I, Schneider, J, Birchmeier, C, Fielitz, J, Spuler, S, Weber-Carstens, S, Enseñat, L, Pérez-Madrigal, A, Briassouli, E, Saludes, P, Proença, L, Elsayed, AA, Meço, B, Gruartmoner, G, Espinal, C, Mesquida, J, Huber, W, Eckmann, M, Elkmann, F, Goukos, D, Gruber, A, Lahmer, T, Mayr, U, Herner, A, Özçelik, M, Abougabal, AM, Schellnegger, R, Schmid, RM, Ayoub, W, Psarra, K, Samy, W, Esmat, A, Battah, A, Mukhtar, S, Mongkolpun, W, Ünal, N, Cortés, DO, Beshey, BN, Cordeiro, CP, Vincent, JL, Leite, MA, Creteur, J, Funcke, S, Groesdonk, H, Saugel, B, Wagenpfeil, G, Wagenpfeil, S, Reuter, DA, Fernandez, MM, Alzahaby, KM, Botoula, E, Fernandez, R, Magret, M, González-Castro, A, Bouza, MT, Ibañez, M, García, C, Balerdi, B, Jenni-Moser, B, Mas, A, Arauzo, V, Tsagarakis, S, Añón, JM, Pozzebon, S, Ruiz, F, Ferreres, J, Tomás, R, Alabert, M, Tizón, AI, Altaba, S, Jeitziner, MM, Llamas, N, Haroon, BA, Edul, VS, Goligher, EC, Fan, E, Herridge, M, Ortiz, AB, Vorona, S, Sklar, M, Dres, M, Rittayamai, N, Lanys, A, Schreiber, J, Mageira, E, Urrea, C, Tomlinson, G, Reid, WD, Rubenfeld, GD, Kavanagh, BP, Cristallini, S, Brochard, LJ, Ferguson, ND, Neto, AS, De Abreu, MG, Routsi, C, Imiela, J, Galassi, MS, Pelosi, P, Schultz, MJ, PRoVENT investigators and the PROVE Network, Guérin, C, Papazian, L, Reignier, J, Lheureux, O, Ayzac, L, Nanas, S, Loundou, A, Forel, JM, Sales, FL, Rolland-Debord, C, Bureau, C, Poitou, T, Clavel, M, Perbet, S, Terzi, N, Kouatchet, A, Briassoulis, G, Brasseur, A, Similowski, T, Demoule, A, De Moraes, KC, Hunfeld, N, Trogrlic, Z, Ladage, S, Osse, RJ, Koch, B, Rietdijk, W, Boscolo, A, Devlin, J, Van der Jagt, M, Picetti, E, Batista, CL, Ceccarelli, P, Mensi, F, Malchiodi, L, Risolo, S, Rossi, I, Bertini, D, Antonini, MV, Servadei, F, Caspani, ML, Roquilly, A, Júnior, JA, Lasocki, S, Seguin, P, Geeraerts, T, Perrigault, PF, Campello, E, Dahyot-Fizelier, C, Paugam-Burtz, C, Cook, F, Cinotti, R, Dit Latte, DD, Mahe, PJ, Marcari, TB, Fortuit, C, Feuillet, F, Lucchetta, V, Asehnoune, K, Marzorati, C, Spina, S, Scaravilli, V, Vargiolu, A, Riva, M, Giussani, C, Lobato, R, Sganzerla, E, Hravnak, M, Osaku, EF, Citerio, G, Barbadillo, S, De Molina, FJ, Álvarez-Lerma, F, Rodríguez, A, SEMICYUC/GETGAG Working Group, Zakharkina, T, Martin-Loeches, I, Castro, CS, Matamoros, S, Fuhrmann, V, Piasentini, E, Povoa, P, Yousef, K, Torres, A, Kastelijn, J, Hofstra, JJ, De Jong, M, Schultz, M, Sterk, P, Artigas, A, De Souza, LM, Aktepe, O, Bos, LJ, Moreau, AS, Chang, Y, Salluh, J, Rodriguez, A, Nseir, S, TAVeM study group, De Jong, E, Fildisis, G, Rodrigues, FF, Van Oers, JA, Beishuizen, A, Girbes, AR, Nijsten, MW, Crago, E, De Lange, DW, Bonvicini, D, Labate, D, Benacchio, L, Radu, CM, Olivieri, A, Stepinska, J, Wruck, ML, Pizzirani, E, Lopez-Delgado, JC, Gonzalez-Romero, M, Fuentes-Mila, V, Berbel-Franco, D, Friedlander, RM, Romera-Peregrina, I, Manesso, L, Martinez-Pascual, A, Perez-Sanchez, J, Abellan-Lencina, R, Correa, NG, Ávila-Espinoza, RE, Moreno-Gonzalez, G, Sbraga, F, Griffiths, S, Grocott, MP, Creagh-Brown, B, Simioni, P, Abdelmonem, SA, POPC-CB investigators, Doyle, J, Wilkerson, P, Pelegrini, AM, Soon, Y, Huddart, S, Dickinson, M, Riga, A, Zuleika, A, Ori, C, Miyamoto, K, Kawazoe, Y, Tahon, SA, Morimoto, T, Yamamoto, T, Eid, RA, Fuke, A, Hashimoto, A, Koami, H, Beppu, S, Su, H, Katayama, Y, Ito, M, Ohta, Y, Yamamura, H, Helmy, TA, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, Timenetsky, KT, Rygård, SL, Holst, LB, Wetterslev, J, Lam, YM, Johansson, PI, Perner, A, Soliman, IW, Van Dijk, D, Van Delden, JJ, Meligy, HS, Cazati, D, Cremer, OL, Slooter, AJ, Willis, K, Peelen, LM, McWilliams, D, Snelson, C, Neves, AD, Loudet, CI, Busico, M, Vazquez, D, Villalba, D, Lobato, M, Puig, F, Kott, M, Pullar, V, Veronesi, M, Lischinsky, A, López, FJ, Mori, LB, Plotnikow, G, Díaz, A, Giannasi, S, Hernandez, R, Krzisnik, L, Diniz, PS, Hubner, RP, Cecotti, C, Dunn-Siegrist, I, Viola, L, Lopez, R, Sottile, JP, Benavent, G, Estenssoro, E, Chen, CM, Lai, CC, Cheng, KC, Costa, CR, Rocha, LL, Chou, W, Chan, KS, Pugin, J, Roeker, LE, Horkan, CM, Gibbons, FK, Christopher, KB, Weijs, PJ, Mogensen, KM, Furche, M, Rawn, JD, Cavalheiro, AM, Robinson, MK, Tang, Z, Gupta, S, Qiu, C, Ouyang, B, Cai, C, Guan, X, Tsang, JL, Regueira, T, Cea, L, Topeli, A, Lucinio, NM, Carlos, SJ, Elisa, B, Puebla, C, Vargas, A, Govil, D, Poulsen, MK, De Guadiana-Romualdo, LG, Thomsen, LP, Kjærgaard, S, Rees, SE, Karbing, DS, Schwedhelm, E, Frank, S, Müller, MC, Carbon, NM, Skrypnikov, V, Rebollo-Acebes, S, Srinivasan, S, Pickerodt, PA, Falk, R, Mahlau, A, Santos, ER, Lee, A, Inglis, R, Morgan, R, Barker, G, Esteban-Torrella, P, Kamata, K, Abe, T, Patel, SJ, Saitoh, D, Tokuda, Y, Green, RS, Norrenberg, M, Butler, MB, Erdogan, M, Hwa, HT, Jiménez-Sánchez, R, Gil, LJ, Vaquero, RH, Rodriguez-Ruiz, E, Lago, AL, N, JK, Allut, JL, Gestal, AE, Gleize, A, Gonzalez, MA, Thomas-Rüddel, DO, Jiménez-Santos, E, Schwarzkopf, D, Fleischmann, C, Reinhart, K, Suwanpasu, S, Sattayasomboon, Y, Filho, NM, Gupta, A, Oliveira, JC, Preiser, JC, Ballalai, CS, Zitta, K, Ortín-Freire, A, De Lucia, CV, Araponga, GP, Veiga, LN, Silva, CS, Garrido, ME, Ramos, BB, Ricaldi, EF, Gomes, SS, Tomar, DS, Simón, IF, Hernando-Holgado, A, GEMINI, Gemmell, L, MacKay, A, Wright, C, Docking, RI, Doherty, P, Black, E, Stenhouse, P, Plummer, MP, Finnis, ME, Albaladejo-Otón, MD, Carmona, SA, Shafi, M, Phillips, LK, Kar, P, Bihari, S, Biradar, V, Moodie, S, Horowitz, M, Shaw, JE, Deane, AM, Coelho, L, Yatabe, T, Valhonrat, IL, Inoue, S, Harne, R, Sakaguchi, M, Egi, M, Abdelhamid, YA, Motta, MF, Domínguez, JP, Arora, DP, Hokka, M, Pattinson, KT, Mizobuchi, S, Pérez, AG, Abellán, AN, Plummer, M, Giersch, E, Talwar, N, Summers, M, Pelenz, M, Hatzinikolas, S, Heller, S, Chapman, M, Jones, K, Almudévar, PM, Schweizer, R, Jacquet-Lagreze, M, Portran, P, Rabello, L, Mazumdar, S, Junot, S, Allaouchiche, B, Fellahi, JL, Guerci, P, Ergin, B, Lange, K, Kapucu, A, Ince, C, Cioccari, L, Luethi, N, Crisman, M, Papakrivou, EE, Bellomo, R, Mårtensson, J, Shinotsuka, CR, Fagnoul, D, Kluge, S, Orbegozo, D, Makris, D, Thooft, A, Brimioulle, S, Dávila, F, Iwasaka, H, Brandt, B, Tahara, S, Nagamine, M, Ichigatani, A, Cabrera, AR, Zepeda, EM, Granillo, JF, Manoulakas, E, Sánchez, JS, Montoya, AA, Rubio, JJ, Montenegro, AP, Blanco, GA, Robles, CM, Drolz, A, Horvatits, T, Roedl, K, Rutter, K, Tsolaki, B, Funk, GC, Póvoa, P, Ramos, AJ, Schneeweiss, B, Sabetian, G, Pooresmaeel, F, Zand, F, Ghaffaripour, S, Farbod, A, Tabei, H, Taheri, L, TAVeM study Group, Karadodas, B, Reina, Á, Anandanadesan, R, Metaxa, V, Teixeira, C, Pereira, SM, Hernández-Marrero, P, Carvalho, AS, Beckmann, M, Hartog, CS, Varis, E, Raadts, A, López, NP, Zakynthinos, E, Robertsen, A, Førde, R, Skaga, NO, Helseth, E, Honeybul, S, Ho, K, Vazquez, AR, Lopez, PM, Gonzalez, MN, Ortega, PN, Pérez, MA, Sola, EC, Garcia, IP, Spasova, T, De la Torre-Prados, MV, Kopecky, O, Rusinova, K, Pettilä, V, Waldauf, P, Cepeplikova, Z, Balik, M, Ordoñez, PF, Apolo, DX, Almudevar, PM, Martin, AD, Muñoz, JJ, Poukkanen, M, Castañeda, DP, Villamizar, PR, Ramos, JV, Pérez, LP, Lucendo, AP, Villén, LM, Ejarque, MC, Estella, A, Camps, VL, Neitzke, NM, Encinares, VS, Martín, MC, Masnou, N, Bioethics work group of SEMICYUC, Barbosa, S, Varela, A, Palma, I, López, FM, Cristina, L, Nunes, E, Jacob, S, Pereira, I, Campello, G, Ibañez, MP, Granja, C, Pande, R, Pandey, M, Varghese, S, Chanu, M, García, IP, Van Dam, MJ, Schildhauer, C, Karlsson, S, Ter Braak, EW, Gracia, M, Viciana, R, Montero, JG, Recuerda, M, Fontaiña, LP, Tharmalingam, B, Kovari, F, Zöllner, C, Rose, L, Mcginlay, M, Amin, R, Burns, K, Connolly, B, Hart, N, Labrador, G, Jouvet, P, Katz, S, Leasa, D, Takala, J, Izurieta, JR, Mawdsley, C, Mcauley, D, Blackwood, B, Denham, S, Worrall, R, Arshad, M, Cangueiro, TC, Isherwood, P, Wilkman, E, Khadjibaev, A, Guerrero, JJ, Sabirov, D, Rosstalnaya, A, Parpibaev, F, Sharipova, V, Guzman, CI, FINNAKI Study Group, Poulose, V, Renal Transplantation HUVR, Lundberg, OH, Koh, J, Calvert, S, Cha, YS, Lee, SJ, Tyagi, N, Rajput, RK, Birri, PN, Taneja, S, Singh, VK, Sharma, SC, Mittal, S, Quint, M, Kam, JW, Rao, BK, Ayachi, J, Fraj, N, Romdhani, S, Bergenzaun, L, Khedher, A, Meddeb, K, Sma, N, Azouzi, A, Bouneb, R, Giribet, A, Adeniji, K, Chouchene, I, Yeter, H, El Ghardallou, M, Rydén, J, Boussarsar, M, Jennings, R, Walter, E, Ribeiro, JM, Moniz, I, Marçal, R, Santos, AC, Young, R, Candeias, C, E Silva, ZC, Rosenqvist, M, Kara, A, Gomez, SE, Nieto, OR, Gonzalez, JA, Cuellar, AI, Mildh, H, Korhonen, AM, Shevill, DD, Elke, G, Moraes, MM, Ala-Kokko, T, Reinikainen, M, Robertson, E, Garside, P, Tavladaki, T, Isotti, P, De Vecchi, MM, Perduca, AE, Cuervo, MA, Melander, O, Negro, A, Villa, G, Manara, DF, Cabrini, L, Zangrillo, A, Frencken, JF, Spanaki, AM, Van Baal, L, Donker, DW, Chew, MS, Cuervo, RA, Horn, J, Van der Poll, T, Van Klei, WA, Bonten, MJ, Menard, CE, Kumar, A, Dimitriou, H, Rimmer, E, Doucette, S, Esteban, MA, Turgeon, AF, Houston, BL, Houston, DS, Zarychanski, R, Pinto, BB, Carrara, M, Ferrario, M, Bendjelid, K, Kondili, E, Nunes, J, Fraile, LI, Diaz, P, Silva, G, Escórcio, S, Chaves, S, Jardim, M, Fernandes, N, Câmara, M, Duarte, R, Pereira, CA, Choulaki, C, Mittelbrum, CP, Vieira, J, Nóbrega, JJ, De Oca-Sandoval, MA, Sánchez-Rodríguez, A, Joya-Galeana, JG, Correa-Morales, A, Camarena-Alejo, G, Aguirre-Sánchez, J, Franco-Granillo, J, Albaiceta, GM, Meleti, E, Soliman, M, Al Azab, A, El Hossainy, R, Nagy, H, Nirmalan, M, Crippa, IA, Cavicchi, FZ, Koeze, J, Kafetzopoulos, D, Chaari, A, Hakim, KA, Hassanein, H, Etman, M, El Bahr, M, Bousselmi, K, Khalil, ES, Kauts, V, Tsolakoglou, I, Casey, WF, Imahase, H, Georgopoulos, D, Sakamoto, Y, Yamada, KC, Miike, T, Nagashima, F, Iwamura, T, Keus, F, Hummitzsch, L, Kishihara, Y, Heyland, D, Spiezia, L, Dieperink, W, Souza, RB, Yasuda, H, Martins, AM, Liberatore, AM, Kang, YR, Nakamae, MN, La Torre, AG, Vieira, JC, Koh, IH, Hanslin, K, Wilske, F, Van der Horst, IC, Jaskowiak, JL, Skorup, P, Sjölin, J, Lipcsey, M, Long, WJ, Zhen, CE, Vakalos, A, Avramidis, V, Wu, SH, Shyu, LJ, Rebollo, S, Van Meurs, M, Li, CH, Yu, CH, Chen, HC, Wang, CH, Lin, KH, Aray, ZE, Gómez, CF, Tsvetanova-Spasova, T, Tejero, AP, Monge, DD, Zijlstra, JG, Losada, VM, Tarancón, CM, Cortés, SD, Gutiérrez, AM, Álvarez, TP, Rouze, A, Jaffal, K, Six, S, Jimenez, R, Nuevo-Ortega, P, Stolz, K, Roberts, S, Cattoen, V, Arnal, JM, Saoli, M, Novotni, D, Garnero, A, Becher, T, Torrella, PE, Buchholz, V, Schädler, D, Rueda-Molina, C, Caballero, CH, Frerichs, I, Weiler, N, Eronia, N, Mauri, T, Gatti, S, Maffezzini, E, Fernandez, A, Bronco, A, Alban, L, Sasso, T, Marenghi, C, Isgro, G, Fernández-Porcel, A, Grasselli, G, Pesenti, A, Bellani, G, Al-Fares, A, Dubin, A, Del Sorbo, L, Anwar, S, Facchin, F, Azad, S, Zamel, R, Hall, D, Ferguson, N, Camara-Sola, E, Cypel, M, Keshavjee, S, Sanchez, S, Durlinger, E, Spoelstra-de Man, A, Smit, B, De Grooth, HJ, Girbes, A, Beitland, S, Straaten, HO, Smulders, Y, Salido-Díaz, L, Ortin, A, Alfaro, MA, Parrilla, F, Meli, A, Pellegrini, M, Rodriguez, N, Goyeneche, JM, Morán, I, Intas, G, Aguirre, H, Mancebo, J, Bassi, GL, Heines, SJ, García-Alcántara, A, Strauch, U, Bergmans, DC, Blankman, P, Shono, A, Hasan, D, Gommers, D, Trøseid, AM, Chung, WY, Prats, RG, Lee, KS, Jung, YJ, Park, JH, Sheen, SS, Park, KJ, Worral, R, Brusletto, BS, Larraza, S, Dey, N, Spadaro, S, Brohus, JB, Winding, RW, Volta, CA, Silva, MM, Waldum-Grevbo, BE, Ampatzidou, F, Vlachou, A, Kehagioglou, G, Karaiskos, T, Madesis, A, Mauromanolis, C, Michail, N, Drossos, G, Aguilera, E, Saraj, N, Berg, JP, Rijkenberg, S, Feijen, HM, Endeman, H, Donnelly, AA, Morgan, E, Garrard, H, Buckley, H, Russell, L, Marti, D, Haase, N, Sunde, K, Goh, C, Mouyis, K, Woodward, CL, Halliday, J, Encina, GB, Ros, J, Ranzani, OT, Lagunes, L, Tabernero, J, Huertas, DG, Bosch, F, Rello, J, Manzano, F, Morente-Constantin, E, Rivera-Ginés, B, Rigol, M, Colmenero-Ruiz, M, Meleti, DE, Sanz, JG, Dogliotti, A, Simon, IF, Valbuena, BL, Pais, M, Ramalingam, S, Quintana, MM, Díaz, C, Fox, L, Santafe, M, Fernandez, L, Barba, P, García, M, Leal, S, Pérez, M, Pérez, ML, Osuna, A, Ferrer, M, Veganzones, J, Martínez, N, Santiago-Ruiz, F, Moors, I, Mokart, D, Pène, F, Lambert, J, Mayaux, J, Vincent, F, Nyunga, M, Bruneel, F, Stergiannis, P, Laisne, L, Rabbat, A, Lebert, C, Perez, P, Suberviola, B, Chaize, M, Renault, A, Meert, AP, Hamidfar, R, Jourdain, M, Rodríguez-Mejías, C, Lanziotti, VS, Darmon, M, Schlemmer, B, Chevret, S, Lemiale, V, Azoulay, E, Rowland, MJ, Riera, J, Benoit, D, Martins-Branco, D, Sousa, M, Wangensteen, R, Marum, S, Bouw, MJ, Galstyan, G, Makarova, P, Parovichnikova, E, Kuzmina, L, Troitskaya, V, Rellan, L, Drize, N, Zaponi, RS, Gemdzhian, E, Jamaati, HR, Savchenko, V, Chao, HC, Kılıc, E, Demiriz, B, Uygur, ML, Sürücü, M, Cınar, K, Yıldırım, AE, Pulcheri, L, Sanchez, M, Kiss, K, Masjedi, M, Köves, B, Csernus, V, Molnár, Z, Ntantana, A, Matamis, D, Savvidou, S, Giannakou, M, Ribeiro, MO, Gouva, M, Nakos, G, Robles, JC, Koulouras, V, Gaffney, S, Docking, R, Judge, C, Drew, T, Barbosa, AP, Misran, H, Munshi, R, McGovern, L, Coyle, M, Hashemian, SM, Lopez, E, Dunne, L, Deasy, E, Lavin, P, Fahy, A, Antoniades, CA, Ramos, A, Darcy, DM, Donnelly, M, Ismail, NH, Hall, T, Wykes, K, Jack, J, Vicente, R, Ngu, WC, Morgan, P, E Silva, JR, Ruiz-Ramos, J, Ramirez, P, Gordon, M, Villarreal, E, Frasquet, J, Poveda-Andrés, JL, Abbasi, G, Castellanos, A, Ijssennagger, CE, Miñambres, E, Soares, M, Ten Hoorn, S, Van Wijk, A, Van den Broek, JM, Tuinman, PR, Elmenshawy, AM, Hammond, BD, Gibbon, G, Khaloo, V, Belcham, T, Burton, K, Salluh, JI, Taniguchi, LU, Santibañez, M, Ramos, FJ, Momma, AK, Martins-Filho, AP, Bartocci, JJ, Lopes, MF, Sad, MH, Tabei, SH, Rodrigues, CM, Pires, EM, Vieira, JM, Le Guen, M, Murbach, LD, Barreto, J, Duarte, ST, Taba, S, Kolaros, AA, Miglioranza, D, Gund, DP, Lordani, CF, Ogasawara, SM, Moore, J, Jorge, AC, Duarte, PA, Capuzzo, M, Marqués, MG, Kafilzadeh, A, Corte, FD, Terranova, S, Scaramuzzo, G, Fogagnolo, A, Bertacchini, S, Bellonzi, A, Garry, P, Mason, N, Ragazzi, R, Moreno, AP, Bakhodaei, HH, Cruz, C, Nunes, A, Pereira, FS, Aragão, I, Cardoso, AF, Santos, C, Malheiro, MJ, Castro, H, Abentroth, LR, Windpassinger, M, Cardoso, T, Diaz, JA, Paratz, J, Kenardy, J, Comans, T, Coyer, F, Thomas, P, Boots, R, Pereira, N, Pizarraya, AG, Vilas-Boas, A, Gomes, E, Plattner, O, Silva, R, Dias, C, Torres, J, Carvalho, D, Molinos, E, Vales, C, Araújo, R, Witter, T, Diaz, JP, Garcia, DJ, Mascha, E, Lovesio, C, Karnatovskaia, L, Philbrick, K, Ognjen, G, Clark, M, Montero, RM, Luis, E, Varas, JL, Sessler, DI, Sánchez-Elvira, LA, Delgado, CP, Díaz, PV, Ruiz, BL, Guerrero, AP, Galache, JA, Jiménez, R, Gomez, MN, Alejandro, O, Fernández, A, Research, O, Smani, Y, Moreno, S, Herrera, L, Ojados, A, Galindo, M, Murcia, J, Contreras, M, Sánchez-Argente, S, Soriano, R, Bonilla, Y, Rodríguez, MD, Connell, MM, Allegue, JM, Melia, U, Cakin, Ö, Parlak, H, Kirca, H, Mutlu, F, Aydınlı, B, Cengiz, M, Gonzalez, PL, Ramazanoglu, A, Zhang, LA, Jung, EJ, Oh, SY, Lee, H, Fontanet, J, Ibrahim, IA, Parker, RS, Van den Berg, JP, Domenech, JC, Montalvo, AP, Banerjee, I, Chalari, E, Chornet, TC, Martinez, PC, Ribas, MP, Costa, RG, Ortega, AC, Forbes, C, Struys, MM, Prescott, H, Lal, A, Clermont, G, Khan, FA, Rafik, MM, Dela Pena, EG, Dizon, JS, Perez, PP, Wong, CM, Garach, MM, Romero, OM, Puerta, RR, Westbrook, J, Norberg, E, Vereecke, HE, Diaz, FA, Al-Ansary, AM, Bailon, AM, Pinel, AC, Maldonado, LP, Kalaiselvan, MS, Kumar, RL, Renuka, MK, Kumar, AS, Myatra, SN, De Rosa, S, Ferrari, F, Jensen, EW, Algendi, MA, Checcacci, SC, Rigobello, A, Joannidis, M, Politi, F, Pellizzari, A, Bonato, R, Oras, J, Fernandez-Carmona, A, Macias-Guarasa, I, Gutierrez-Rodriguez, R, Martinez-Lopez, P, Ali, AA, Rood, PJ, Diaz-Castellanos, MA, EDISVAL Group, Arias-Diaz, M, Vaara, ST, Aguilar-Alonso, E, Nikandish, RN, Van de Schoor, F, Artemenko, V, Budnyuk, A, Delile, E, Senussi, T, Idone, F, Xiol, EA, Travierso, C, Chiurazzi, C, Motos, A, Amaro, R, Van Tertholen, K, Cuisinier, A, Hua, Y, Fernández-Barat, L, Bobi, Q, Youn, A, Hwang, JG, Maufrais, C, Pickkers, P, Ossorio, ME, Figueira, H, Payen, JF, Oliveira, R, Mota, A, Van den Boogaard, M, Kamp, O, Cruciger, O, Aach, M, Kaczmarek, C, Waydhas, C, Nottin, S, Schildhauer, TA, Hamsen, U, Camprubí-Rimblas, M, Chimenti, L, Guillamat-Prats, R, Beardow, ZJ, Lebouvier, T, Bringué, J, Tijero, J, Gómez, MN, Walther, G, Benten, D, Blanch, L, Tagliabue, G, Ji, M, Jagers, JV, Easton, PA, Redhead, H, Athanasiadou, E, Hong, JY, Shin, MH, Park, MS, Paramasivam, K, Albrecht, M, Arib, S, Pomprapa, A, Kluwe, J, Hofferberth, MB, Russ, M, Braun, W, Walter, M, Francis, R, Lachmann, B, Leonhardt, S, Bilotta, F, Corkill, R, Numan, T, Siedler, S, Landaverde-López, A, Canedo-Castillo, NA, Badenes, R, Esquivel-Chávez, A, Arvizu-Tachiquín, PC, Sánchez-Hurtado, LA, Baltazar-Torres, JA, Cardoso, V, Krystopchuk, A, Castro, S, Melão, L, Firmino, S, Marreiros, A, Almaziad, S, Kubbara, A, Adedugbe, I, Barnett, W, Kamper, AM, Nakity, R, Alamoudi, W, Strickland, R, Altook, R, Tarazi, T, Fida, M, Safi, F, Assaly, R, Santini, A, Bird, GT, Milesi, M, Maraffi, T, Rood, P, Rubulotta, F, Pugni, P, Andreis, DT, Cavenago, M, Gattinoni, L, Protti, A, Perchiazzi, G, Borges, JB, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Bayat, S, Porra, L, Mirek, S, Broche, L, Hedenstierna, G, Larsson, A, Kennedy, RM, Roneus, A, Segelsjö, M, Vestito, MC, Zeman, PM, Gremo, E, Nyberg, A, Castegren, M, Pikwer, A, Sharma, S, Monfort, B, Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Brochard, L, Amato, MB, Stazi, E, PLUG Working group, Koch, N, Hoellthaler, J, Mair, S, Phillip, V, Van Ewijk, CE, Beitz, A, González, LR, Roig, AL, Baladrón, V, Yugi, G, Calvo, FJ, Padilla, D, Villarejo, P, Villazala, R, Yuste, AS, Bejarano, N, Steenstra, RJ, Jacobs, GE, Banierink, H, Hof, J, Martika, A, Hoekstra, M, Sterz, F, Horvatits, K, Herkner, H, Magnoni, S, Marando, M, Faivre, V, Pifferi, S, Conte, V, Ortolano, F, Alonso, DC, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Nevière, R, Stocchetti, N, Fatania, G, Hernández-Sánchez, N, Rotzel, HB, Lázaro, AS, Prada, DA, Guimillo, MR, Piqueras, CS, Guia, JR, Simon, MG, Thiébaut, PA, Arizmendi, AM, Carratalá, A, Sánchez, RDEP, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, FN, Bianchin, MM, Vieira, SR, Maupoint, J, De Souza, A, Lucas, JH, Backes, AN, Klein, C, García-Guillen, FJ, Arunkumar, AS, Lozano, A, Mulder, P, Gallaher, C, Cattlin, S, Ñamendys-Silva, SA, Gordon, S, Picard, J, Fontana, V, Bond, O, Coquerel, D, Nobile, L, Mrozek, S, Delamarre, L, Maghsoudi, B, Capilla, F, Al-Saati, T, Fourcade, O, Renet, S, Dominguez-Berrot, AM, Gonzalez-Vaquero, M, Vallejo-Pascual, ME, Gupta, D, Ivory, BD, Chopra, M, Emami, M, Khaliq, W, McCarthy, J, Felderhof, CL, Do Rego, JC, MacNeil, C, Maggiorini, M, Duska, F, Department of Professional Development, ESICM, Fumis, RR, Junior, JM, Khosravi, MB, Amarante, G, Rieusset, J, Skorko, A, Sanders, S, Aron, J, Kroll, RJ, Redfearn, C, Harish, MM, Krishnan, P, Khalil, JE, Kongpolprom, N, Richard, V, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Tamion, F, Tabatabaie, HR, Hayward, J, Baldwin, F, Gray, R, Katinakis, PA, Stijf, M, Ten Kleij, M, Jansen-Frederiks, M, Broek, R, De Bruijne, M, Mengelle, C, Spronk, PE, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu-Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Strong, AJ, Sabetiyan, G, Glace, S, Jeyabraba, S, Lewis, HF, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, LM, Zolfaghari, P, Baptista, JP, Mokri, A, Marques, MP, Martins, P, Pimentel, J, Su, YC, Singer, M, Villacres, S, Stone, ME, Parsikia, A, Medar, S, O'Dea, KP, Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Porter, J, Tirlapur, N, Jonathan, JM, Singh, S, Takata, M, Critical Care Research Group, McWhirter, E, Lyon, R, Troubleyn, J, Hariz, ML, Ferlitsch, A, Azmi, E, Alkhan, J, Smulders, YM, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Diltoer, M, Merz, T, Hartmann, C, De Waard, MC, Calzia, E, Radermacher, P, Nußbaum, B, Huber-Lang, M, Fauler, G, Gröger, M, Jacobs, R, Zaleska-Kociecka, M, Van Straaten, HM, Trauner, M, Svoren-Jabalera, E, Davenport, EE, Humburg, P, Nguyen, DN, Knight, J, Hinds, CJ, Jun, IJ, Prabu, NR, Kim, WJ, Lee, EH, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Eringa, EC, De Waele, E, Samain, E, Chocron, S, Pili-Floury, S, Plata-Menchaca, EP, Sabater-Riera, J, Estruch, M, Boza, E, Toscana-Fernández, J, Man, AM, Bruguera-Pellicer, E, De Regt, J, Ordoñez-Llanos, J, Pérez-Fernández, XL, SIRAKI group, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, JP, Lebrun, M, Favier, B, Pischke, S, Cholley, B, PerezVela, JL, Honoré, PM, MarinMateos, H, Rivera, JJ, Llorente, MA, De Marcos, BG, Fernandez, FJ, Laborda, CG, Zamora, DF, Fischer, L, Alegría, L, Grupo ESBAGA, Delgado, JC, Imperiali, C, Myers, RB, Van Gorp, V, Dastis, M, Thaiss, F, Soto, D, Górka, J, Spapen, HD, Górka, K, Iwaniec, T, Koch, M, Frołow, M, Polok, K, Luengo, C, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Contreras, RS, Bangert, K, Gomez, J, Sileli, M, Havaldar, AA, Toapanta, ND, Jarufe, N, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, Moreno, G, Grabowski, M, Bruhn, A, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Sabater, J, Castro, R, Thomas-Rueddel, DO, Vlasakov, V, Lohse, AW, Rochwerg, B, Theurer, P, Al Sibai, JZ, Camblor, PM, Kattan, E, Torrado, H, Siddiqui, S, Fernandez, PA, Gala, JM, Guisasola, JS, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Tapia, P, Nashan, B, Gonzalez, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, KE, Sterneck, M, Rebolledo, R, Purtle, SW, Marin, M, Viana, MV, Tonietto, TA, Gross, LA, Costa, VL, Faenza, S, Tavares, AL, Payen, D, Lisboa, BO, Moraes, RB, Farigola, E, Viana, LV, Azevedo, MJ, Ceniccola, GD, Pequeno, RS, Siniscalchi, A, Holanda, TP, Mendonça, VS, Achurra, P, Araújo, WM, Carvalho, LS, Segaran, E, Vickers, L, Gonzalez, A, Brinchmann, K, Pierucci, E, Wignall, I, De Brito-Ashurst, I, Ospina-Tascón, G, Del Olmo, R, Esteban, MJ, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Mancini, E, Fernandez, J, Nieto, B, Fuentes, M, De la Torre, MA, Bakker, J, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Krishna, B, Grip, J, Kölegård, R, Vera, A, Sundblad, P, Rooyackers, O, Hernández, G, Naser, B, Jaziri, F, Jazia, AB, Barghouth, M, Ricci, D, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Gisbert, X, Turki, S, Dąbrowski, M, Bertini, P, Abdelghni, KB, Abdallah, B, Gemelli, C, Maha, BN, Cánovas, J, Sotos, F, López, A, Lorente, M, Burruezo, A, Torres, D, Juliá, C, Guarracino, F, Cuoghi, A, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Baldassarri, R, Magnani, S, Uya, J, Abdelghani, KB, Abdallah, TB, Geenen, IL, Parienti, JJ, Straaten, HM, Shum, HP, King, HS, Kulkarni, AP, Pinsky, MR, Chan, KC, Corral, L, Yan, WW, Londoño, JG, Cardenas, CL, Pedrosa, MM, Gubianas, CM, Bertolin, CF, Batllori, NV, Atti, M, Sirvent, JM, Sedation an Delirium Group Hospital Universitari de Bellvitge, Mukhopadhyay, A, Chan, HY, Kowitlawakul, Y, Remani, D, Leong, CS, Henry, CJ, Vera, M, Puthucheary, ZA, Mendsaikhan, N, Begzjav, T, Elias-Jones, I, Lundeg, G, Dünser, M, Espinoza, ED, Welsh, SP, Guerra, E, Poppe, A, Zerpa, MC, Zechner, F, Berdaguer, F, Risso-Vazquez, A, Masevicius, FD, Greaney, D, Dreyse, J, Magee, A, Fitzpatrick, G, Lugo-Cob, RG, Jermaine, CM, Tejeda-Huezo, BC, Cano-Oviedo, AA, Carpio, D, Aydogan, MS, Togal, T, Taha, A, Chai, HZ, Sriram, S, Kam, C, Razali, SS, Sivasamy, V, Randall, D, Kuan, LY, Henriquez, C, Morales, MA, Pires, T, Adwaney, A, Wozniak, S, Gajardo, D, Herrera-Gutierrez, ME, Azevedo, LC, Blunden, M, Prowle, JR, Kirwan, CJ, Thomas, N, Martin, A, Owen, H, Darwin, L, Robertson, CS, Bravo, S, Barrueco-Francioni, J, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'rini, M, Arias-Verdú, D, Rusin, CG, Leger, PL, Cambonie, G, Liet, JM, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lozano-Saez, R, Lecourt, L, Pouard, P, Hofmeijer, J, Kim, SH, Divatia, JV, Na, S, Kim, J, Jung, CW, Sondag, L, Yoo, SH, Min, SH, Chung, EJ, Quesada-Garcia, G, Lee, NJ, Lee, KW, Suh, KS, Ryu, HG, Marshall, DC, Goodson, RJ, Tjepkema-Cloostermans, MC, Salciccioli, JD, Shalhoub, J, Seller-Pérez, G, Potter, EK, Kirk-Bayley, J, Karanjia, ND, Forni, LG, Kim, S, Creagh-Brown, BC, Bossy, M, Nyman, M, Tailor, A, Figueiredo, A, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), D'Antini, D, Valentino, F, Winkler, MS, Sollitto, F, Cinnella, G, Mirabella, L, Anzola, Y, Bosch, FH, Baladron, V, Villajero, P, Lee, M, Redondo, J, Liu, J, Shen, F, Teboul, JL, Anguel, N, Van Putten, MJ, Beurton, A, Bezaz, N, Richard, C, Park, SY, Monnet, X, Fossali, T, Pereira, R, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Piotrowska, K, So, S, Bento, L, Tollisen, KH, Andersen, G, Heyerdahl, F, Jacobsen, D, Van IJzendoorn, MC, Buter, H, Kingma, WP, Navis, GJ, Boerma, EC, Rulisek, J, Zacharov, S, Kim, HS, Jeon, SJ, Namgung, H, Lee, E, Lai, M, Kačar, MB, Cho, YJ, Lee, YJ, Huang, A, Deiana, M, Forsberg, M, Edman, G, Kačar, SM, Höjer, J, Forsberg, S, Freile, MT, Hidalgo, FN, Molina, JA, Lecumberri, R, Rosselló, AF, Travieso, PM, Leon, GT, Uddin, I, Sanchez, JG, Ali, MA, Frias, LS, Rosello, DB, Verdejo, JA, Serrano, JA, Winterwerp, D, Van Galen, T, Vazin, A, Karimzade, I, Belhaj, AM, Zand, A, Ozen, E, Ekemen, S, Akcan, A, Sen, E, Yelken, BB, Kureshi, N, Fenerty, L, Thibault-Halman, G, Aydın, MA, Walling, S, Almeida, R, Seller-Perez, G, Clarke, DB, Briassoulis, P, Kalimeris, K, Ntzouvani, A, Nomikos, T, Papaparaskeva, K, Avsec, D, Politi, E, Kostopanagiotou, G, Crewdson, K, Vardas, K, Rehn, M, Vaz-Ferreira, A, Weaver, A, Brohi, K, Lockey, D, Wright, S, Thomas, K, Mudersbach, E, Baker, C, Mansfield, L, Pozo, MO, Stafford, V, Wade, C, Watson, G, Silva, J, Bryant, A, Chadwick, T, Shen, J, Wilkinson, J, Kapuağası, A, Furneval, J, and Clinical Neurophysiology
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Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group ,TAVeM study Group ,Renal Transplantation HUVR ,Flow (psychology) ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,Critical Care and Intensive Care Medicine ,Grupo ESBAGA ,GEMINI ,03 medical and health sciences ,chemistry.chemical_compound ,SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group) ,0302 clinical medicine ,Critical Care Research Group ,Journal Article ,PRoVENT investigators and the PROVE Network ,Medicine ,Sedation an Delirium Group Hospital Universitari de Bellvitge ,030212 general & internal medicine ,Bioethics work group of SEMICYUC ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) ,SEMICYUC/GETGAG Working Group ,FINNAKI Study Group ,POPC-CB investigators ,business.industry ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,SIRAKI group ,030208 emergency & critical care medicine ,EDISVAL Group ,PLUG Working group ,DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators ,chemistry ,Anesthesia ,Carbon dioxide ,Breathing ,Department of Professional Development, ESICM ,business ,Nurses of the Central and General ICUs of Shiraz Namazi Hospital - Abstract
Contains fulltext : 172382.pdf (Publisher’s version ) (Open Access)
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- 2016
10. Lung stress and strain during mechanical ventilation : any difference between statics and dynamics?
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Protti, A, Andreis, D, Monti, M, Santini, A, Sparacino, C, Langer, T, Votta, E, Gatti, S, Lombardi, L, Leopardi, O, Masson, S, Cressoni, M, Gattinoni, L, Andreis, DT, Sparacino, CC, Protti, A, Andreis, D, Monti, M, Santini, A, Sparacino, C, Langer, T, Votta, E, Gatti, S, Lombardi, L, Leopardi, O, Masson, S, Cressoni, M, Gattinoni, L, Andreis, DT, and Sparacino, CC
- Abstract
OBJECTIVE: Tidal volume (VT) and volume of gas caused by positive end-expiratory pressure (VPEEP) generate dynamic and static lung strains, respectively. Our aim was to clarify whether different combinations of dynamic and static strains, resulting in the same large global strain, constantly produce lung edema. DESIGN:: Laboratory investigation. SETTING: Animal unit. SUBJECTS:: Twenty-eight healthy pigs. INTERVENTIONS: After lung computed tomography, 20 animals were ventilated for 54 hrs at a global strain of 2.5, either entirely dynamic (VT 100% and VPEEP 0%), partly dynamic and partly static (VT 75-50%and VPEEP 25-50%), or mainly static (VT 25% and VPEEP 75%) and then killed. In eight other pigs (VT 25% and VPEEP 75%), VPEEP was abruptly zeroed after 36-54 hrs and ventilation continued for 3 hrs. MEASUREMENTS AND MAIN RESULTS: Edema was diagnosed when final lung weight (balance) exceeded the initial weight (computed tomography). Mortality, lung mechanics, gas exchange, pulmonary histology, and inflammation were evaluated. All animals ventilated with entirely dynamic strain (VT 825 ± 424 mL) developed pulmonary edema (lung weight from 334 ± 38 to 658 ± 99 g, p < 0.01), whereas none of those ventilated with mainly static strain (VT 237 ± 21 mL and VPEEP 906 ± 114 mL, corresponding to 19 ± 1 cm H2O of positive end-expiratory pressure) did (from 314 ± 55 to 277 ± 46 g, p = 0.65). Animals ventilated with intermediate combinations finally had normal or largely increased lung weight. Smaller dynamic and larger static strains lowered mortality (p < 0.01), derangement of lung mechanics (p < 0.01), and arterial oxygenation (p < 0.01), histological injury score (p = 0.03), and bronchoalveolar interleukin-6 concentration (p < 0.01). Removal of positive end-expiratory pressure did not result in abrupt increase in lung weight (from 336 ± 36 to 351 ± 77 g, p = 0.51). CONCLUSIONS Lung edema forms (possibly as an all-or-none response) depending not only on global st
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- 2013
11. In vivo conditioning of acid-base equilibrium by crystalloid solutions : an experimental study on pigs
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Langer, T, Carlesso, E, Protti, A, Monti, M, Comini, B, Zani, L, Andreis, D, Iapichino, G, Dondossola, D, Caironi, P, Gatti, S, Gattinoni, L, Andreis, DT, Iapichino, GE, Langer, T, Carlesso, E, Protti, A, Monti, M, Comini, B, Zani, L, Andreis, D, Iapichino, G, Dondossola, D, Caironi, P, Gatti, S, Gattinoni, L, Andreis, DT, and Iapichino, GE
- Abstract
PURPOSE: Large infusion of crystalloids may induce acid-base alterations according to their strong ion difference ([SID]). We wanted to prove in vivo, at constant PCO(2), that if the [SID] of the infused crystalloid is equal to baseline plasma bicarbonate, the arterial pH remains unchanged, if lower it decreases, and if higher it increases. METHODS: In 12 pigs, anesthetized and mechanically ventilated at PCO(2) ≈40 mmHg, 2.2 l of crystalloids with a [SID] similar to (lactated Ringer's 28.3 mEq/l), lower than (normal saline 0 mEq/l), and greater than (rehydrating III 55 mEq/l) baseline bicarbonate (29.22 ± 2.72 mEq/l) were infused for 120 min in randomized sequence. Four hours of wash-out were allowed between the infusions. Every 30 min up to minute 120 we measured blood gases, plasma electrolytes, urinary volume, pH, and electrolytes. Albumin, hemoglobin, and phosphates were measured at time 0 and 120 min. RESULTS: Lactated Ringer's maintained arterial pH unchanged (from 7.47 ± 0.06 to 7.47 ± 0.03) despite a plasma dilution around 12%. Normal saline caused a reduction in pH (from 7.49 ± 0.03 to 7.42 ± 0.04) and rehydrating III induced an increase in pH (from 7.46 ± 0.05 to 7.49 ± 0.04). The kidney reacted to the infusion, minimizing the acid-base alterations, by increasing/decreasing the urinary anion gap, primarily by changing sodium and chloride concentrations. Lower urine volume after normal saline infusion was possibly due to its greater osmolarity and chloride concentration as compared to the other solutions. CONCLUSIONS: Results support the hypothesis that at constant PCO(2), pH changes are predictable from the difference between the [SID] of the infused solution and baseline plasma bicarbonate concentration
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- 2012
12. ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016
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Velasquez, T., Mackey, G., Lusk, J., Kyle, Ug, Fontenot, T., Marshall, P., Shekerdemian, Ls, Coss-Bu, Ja, Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, Jc, Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, Am, Ieperen, Sn, Kinderen, Ep, Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Akcan-Arikan, A., Silva, Jc, Goldsworthy, M., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano, Sm, Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, Ir, El Adawy, As, Mohammed, Hm, Mohamed, An, Parry, Sm, Knight, Ld, Denehy, L., Morton, N., Baldwin, Ce, Sani, D., Kayambu, G., Da Silva, Vz, Phongpagdi, P., Puthucheary, Za, Granger, Cl, Rydingsward, Je, Horkan, Cm, Christopher, Kb, Mcwilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, Lm, Rattray, J., Kenardy, J., Hull, Am, Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, Jc, Rocha, Ll, Freitas, Ff, Cavalheiro, Am, Lucinio, Nm, Lobato, Ms, Ebeling, G., Kraegpoeth, A., Laerkner, E., Brito-Ashurst, I., White, C., Gregory, S., Forni, Lg, Flowers, E., Curtis, A., Wood, Ca, Siu, K., Venkatesan, K., Muhammad, Jb, Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., Molina, Fj, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, Rm, Palencia, E., Jareño, A., Granada, Rm, Ignacio, Ml, Getgag, Working Group, Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Mignot, T., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, Ma, Patel, C., Mohankumar, L., Akhtar, N., Noriega, Sk, Aldana, Nn, León, Jl, Baquero, Jd, Bernal, Ff, Ahmadnia, E., Hadley, Js, Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Jseptic, Clinical Trial Group, Rotzel, Hb, Lázaro, As, Prada, Da, Gimillo, MR, Barinas, Od, Cortes, Ml, Franco, Jf, Roca, Jm, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, Pj, Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, Le, Lesmes, Sp, Romero, Jc, Herrera, An, Pertuz, Ed, Sánchez, Mj, Sanz, Er, Hualde, Jb, Hernández, Aa, Irazabal, Jm, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, Eh, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, Jm, Arias-Verdu, Md, Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Ramírez, Jr, León, Jp, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, Jl, Pérez, H., Calpe, P., Alcala, Ma, Robaglia, D., Perez, C., Lan, Sk, Cunha, Mm, Moreira, T., Santos, F., Lafuente, E., Fernandes, Mj, Silva, Jg, Echeverría, Jg, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, Jc, Araujo, Nj, García-Olivares, P., Keough, E., Dalorzo, M., Tang, Lk, Sousa, I., Díaz, M., Marcos-Zambrano, Lj, Guerrero, Je, Gomez, Se, Lopez, Gd, Cuellar, Ai, Nieto, Or, Gonzalez, Ja, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, Mk, Sampley, S., Sekhri, K., Nandha, R., Aliaga, Fa, Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, Mp, Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, Jf, Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, Ia, Kashiya, S., Golovnya, E., Baikova, Vn, Ageeva, T., Haritydi, T., Kulaga, Ev, Rios-Toro, Jj, Lopez-Caler, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, Mg, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Yd, Jeong, Wy, Kim, Mh, Jeong, Iy, Ahn, My, Ahn, Jy, Han, Sh, Choi, Jy, Song, Yg, Kim, Jm, Ku, Ns, Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, Rm, Romeu, Jd, Antón, Dg, Quinart, A., Martí, At, Laura Navarro Guillamon, Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, Mf, Capcri, Study, Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, Pa, Taggu, A., Renuka, S., Sampath, S., Rood, Pj, Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., Hoeven, Jg, Den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, Mj, Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, Mp, Heiden, Es, Twisk, Jw, Girbes, Ar, Spijkstra, Jj, Bell, C., Peters, K., Feehan, A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Maistry, N., Wijk, A., Rouw, N., Galen, T., Evelein-Brugman, S., Krishna, B., Putzu, A., Fang, M., Berto, Mb, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, St, Toh, Ch, Han, Hs, Gil, Em, Lee, Ds, Park, Cm, Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, Mw, Huang, Wc, Chiang, Ch, Hung, Wt, Cheng, Cc, Lin, Kc, Lin, Sc, Chiou, Kr, Wann, Sr, Shu, Cw, Kang, Pl, Mar, Gy, Liu, Cp, Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, Mf, Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, Jl, Garcia-Gigorro, R., Peiretti, Ma, Lopez-Gude, Mj, Chacon-Alves, S., Renes-Carreño, E., Montejo-González, Jc, Parlevliet, Kl, Touw, Hr, Beerepoot, M., Boer, C., Elbers, Pw, Tuinman, Pr, Abdelmonem, Sa, Helmy, Ta, El Sayed, I., Ghazal, S., Akhlagh, Sh, Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, Am, Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, Pl, Chang, Wy, Lin, Wc, Chen, Cw, Facchin, F., Zarantonello, F., Panciera, G., Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Guanziroli, M., Colombo, A., Tomic, I., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, As, Schmidt, M., Pham, T., Combes, A., Abreu, Mg, Pelosi, P., Schultz, Mj, Prove, Reva Research Network And The Network Investigators, Katira, Bh, Engelberts, D., Giesinger, Re, Ackerley, C., Zabini, D., Otulakowski, G., Post, M., Kuebler, Wm, Mcnamara, Pj, Kavanagh, Bp, Pirracchio, R., Rigon, MR, Carone, M., Chevret, S., Annane, D., Eladawy, S., El-Hamamsy, M., Bazan, N., Elgendy, M., Pascale, G., Vallecoccia, Ms, Cutuli, Sl, Di Gravio, V., Pennisi, Ma, Antonelli, M., Andreis, Dt, Khaliq, W., Singer, M., Hartmann, J., Harm, S., Carmona, Sa, Almudevar, Pm, Abellán, An, Ramos, Jv, Pérez, Lp, Valbuena, Bl, Sanz, Nm, Simón, If, Arrigo, M., Feliot, E., Deye, N., Cariou, A., Guidet, B., Jaber, S., Leone, M., Resche-Rigon, M., Baron, Av, Gayat, E., Frog Icu, Investigators, Balik, M., Kolnikova, I., Maly, M., Waldauf, P., Tavazzi, G., Kristof, J., Herpain, A., Su, F., Post, E., Taccone, F., Vincent, Jl, Creteur, J., Lee, C., Hatib, F., Jian, Z., Buddi, S., Cannesson, M., Fileković, S., Turel, M., Knafelj, R., Gorjup, V., Stanić, R., Gradišek, P., Cerović, O., Mirković, T., Noč, M., Tirkkonen, J., Hellevuo, H., Olkkola, Kt, Hoppu, S., Chiang, Cc, Juan, Wc, Lin, Ph, Fong, Ky, Hou, Ds, Chen, Ys, Paul, M., Bougouin, W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, Jp, Sandroni, C., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., Mchugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, Ra, Brandon, Rb, Zwaag, J., Beunders, R., Kox, M., Gul, F., Arslantas, Mk, Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, Mp, Garcia, Ip, Cordero, M., Martin, Ad, Pallás, Ta, Montero, Jg, Rey, Jr, Malo, Lr, Montoya, Aa, Martinez, Ad, Ayala, Ly, Zepeda, Em, Granillo, Jf, Sanchez, Ja, Alejo, Gc, Cabrera, Ar, Montenegro, Ap, Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, Pg, Frat, Jp, Constan, A., Chrétien, Jm, Mancebo, J., Mercat, A., Richard, Jc, Brochard, L., Wind, Study Group, Soilemezi, E., Koco, E., Savvidou, S., Nouris, C., Matamis, D., Plug Working Group, Di Mussi, R., Spadaro, S., Volta, Ca, Mariani, M., Colaprico, A., Antonio, C., Bruno, F., Grasso, S., Rodriguez, A., Martín-Loeches, I., Díaz, E., Masclans, Jr, Gordo, F., Solé-Violán, J., Bodí, M., Avilés-Jurado, Fx, Trefler, S., Magret, M., Reyes, Lf, Marín-Corral, J., Yebenes, Jc, Esteban, A., Anzueto, A., Aliberti, S., Restrepo, Mi, GETGAG/SEMICYUC, Larsson, Js, Redfors, B., Ricksten, Se, Haines, R., Powell-Tuck, J., Leonard, H., Ostermann, M., Berthelsen, Re, Itenov, Ts, Perner, A., Jensen, Ju, Ibsen, M., Jensen, Ae, Bestle, Mh, Bucknall, T., Dixon, J., Boa, F., Macphee, I., Philips, Bj, Aki, Research Group, St George’s University of London, Saadat, F., Samuels, T., Huddart, S., Mccormick, B., Debrunnar, R., Preece, J., Swart, M., Peden, C., Richardson, S., Forni, L., Kalfon, P., Baumstarck, K., Estagnasie, P., Geantot, Ma, Berric, A., Simon, G., Floccard, B., Signouret, T., Boucekine, M., Fromentin, M., Nyunga, M., Sossou, A., Venot, M., Robert, R., Follin, A., Renault, A., Garrouste, M., Collange, O., Levrat, Q., Villard, I., Thévenin, D., Pottecher, J., Patrigeon, Rg, Revel, N., Vigne, C., Mimoz, O., Auquier, P., Iprea, Study Group, Pawar, S., Jacques, T., Deshpande, K., Pusapati, R., Wood, B., Pulham, Ra, Wray, J., Brown, K., Pierce, C., Nadel, S., Azevedo, Jr, Montenegro, Ws, Rodrigues, Dp, Sousa, Sc, Araujo, Vf, Leitao, Al, Prazeres, Ph, Mendonca, Av, Paula, Mp, Das Neves, A., Loudet, Ci, Busico, M., Vazquez, D., Villalba, D., Lischinsky, A., Veronesi, M., Emmerich, M., Descotte, E., Juliarena, A., Bisso, Mc, Grando, M., Tapia, A., Camargo, M., Ulla, Dv, Corzo, L., Dos Santos, Hp, Ramos, A., Doglia, Ja, Estenssoro, E., Carbonara, M., Magnoni, S., Donald, Cl, Shimony, Js, Conte, V., Triulzi, F., Stretti, F., Macrì, M., Snyder, Az, Stocchetti, N., Brody, Dl, Shimanskiy, V., Savin, I., Chumaev, A., Tjepkema-Cloostermans, Mc, Hofmeijer, J., Beishuizen, A., Hom, H., Blans, Mj, Putten, Mj, Longhi, L., Frigeni, B., Curinga, M., Mingone, D., Beretta, S., Patruno, A., Gandini, L., Vargiolu, A., Ferri, F., Ceriani, R., Rottoli, MR, Lorini, L., Citerio, G., Pifferi, S., Battistini, M., Cordolcini, V., Agarossi, A., Di Rosso, R., Ortolano, F., Lourido, Cm, Cabrera, Jl, Santana, Jd, Alzola, Lm, Del Rosario, Cg, Pérez, Hr, Torrent, Rl, Eslami, S., Dalhuisen, A., Fiks, T., Hanna, Aa, Spronk, Pe, Wood, M., Maslove, D., Muscedere, J., Scott, Sh, Saha, T., Hamilton, A., Petsikas, D., Payne, D., Boyd, Jg, Mcnelly, As, Rawal, J., Connolly, B., Mcphail, Mj, Sidhu, P., Rowlerson, A., Moxham, J., Harridge, Sd, Hart, N., Montgomery, He, Jovaisa, T., Thomas, B., Gupta, D., Wijayatilake, Ds, Shum, Hp, King, Hs, Chan, Kc, Tang, Kb, Yan, Ww, Arias, Cc, Latorre, J., La Rica, As, Garrido, Em, Feijoo, Am, Gancedo, Ch, Tofiño, Al, Rodríguez, Fg, Gemmell, Lk, Campbell, R., Doherty, P., Mackay, A., Singh, N., Vitaller, S., Nagib, H., Prieto, J., Del Arco, A., Zayas, B., Gomez, C., Tirumala, S., Pasha, Sa, Kumari, Bk, Martinez-Lopez, P., Puerto-Morlán, A., Nuevo-Ortega, P., Pujol, Lm, Dolset, Ra, González, Bs, Riera, Sq, Álvarez, Jt, Quintana, S., Martínez, L., Algarte, R., Sánchez, B., Trenado, J., Brock, N., Viegas, E., Filipe, E., Cottle, D., Traynor, T., Martínez, Mv, Márquez, Mp, Gómez, Lc, Martínez, Na, Muñoz, Jm, Bellver, Bq, Varea, Mm, Llorente, Má, Calvo, Cp, Hillier, Sd, Faulds, Mc, Hendra, H., Lawrence, N., Kodate, A., Tominaga, N., Mizugaki, A., Murakami, H., Silva, S., Kerhuel, L., Malagurski, B., Chabanne, R., Laureys, S., Puybasset, L., Nobile, L., Pognuz, Er, Rossetti, Ao, Verginella, F., Gaspard, N., Ben-Hamouda, N., Oddo, M., Taccone, Fs, Iijima, H., Andersen, Lw, Raymond, T., Berg, R., Nadkarni, V., Grossestreuer, A., Kurth, T., Donnino, M., Krüger, A., Ostadal, P., Janotka, M., Vondrakova, D., Kongpolprom, N., Cholkraisuwat, J., Pekkarinen, Pt, Ristagno, G., Masson, S., Latini, R., Bendel, S., Ala-Kokko, T., Varpula, T., Vaahersalo, J., Tiainen, M., Mion, Mm, Plebani, M., Pettilä, V., Skrifvars, Mb, Finnresusci, Study Group, Son, Y., Kim, Ks, Suh, Gj, Kwon, Wy, Ko, Ji, Park, Mj, Cavicchi, Fz, Iesu, E., Tanaka, H., Otani, N., Ode, S., Ishimatsu, S., Romero, I., Martínez, F., Kruger, A., Malek, F., Neuzil, P., Yeh, Yc, Wang, Ch, Huang, Ch, Chao, A., Lee, Ct, Lai, Ch, Chan, Ws, Cheng, Yj, Sun, Wz, Kaese, S., Horstmann, C., Lebiedz, P., Mourad, M., Gaudard, P., Eliet, J., Zeroual, N., Colson, P., Mlcek, M., Hrachovina, M., Mates, M., Hala, P., Kittnar, O., Jacky, A., Rudiger, A., Spahn, Dr, Bettex, Da, Kara, A., Akin, S., Dos Reis Miranda, D., Struijs, A., Caliskan, K., Thiel, Rj, Dubois, Ea, Wilde, W., Zijlstra, F., Gommers, D., Ince, C., Marca, L., Xini, A., Mongkolpun, W., Cordeiro, Cp, Leite, Rt, Lheureux, O., Bader, A., Rincon, L., Santacruz, C., Preiser, Jc, Chao, As, Kim, W., Ahn, C., Cho, Y., Lim, Th, Oh, J., Choi, Ks, Jang, Bh, Ha, Jk, Mecklenburg, A., Stamm, J., Soeffker, G., Kubik, M., Sydow, K., Reichenspurner, H., Kluge, S., Braune, S., Bergantino, B., Ruberto, F., Magnanimi, E., Privato, E., Zullino, V., Bruno, K., Pugliese, F., Sales, G., Girotto, V., Vittone, F., Brazzi, L., Fritz, C., Kimmoun, A., Vanhuyse, F., Trifan, B., Orlowski, S., Albuisson, E., Tran, N., Levy, B., Chhor, V., Joachim, J., Chatelon, J., Fave, G., Mantz, J., Diaz, Dd, Villanova, M., Aguirregabyria, M., Andrade, G., López, L., John, G., Cowan, R., Hart, R., Lake, K., Litchfield, K., Song, Jw, Lee, Yj, Cho, Yj, Choi, S., Vermeir, P., Vandijck, D., Mariman, A., Verhaeghe, R., Deveugele, M., Vogelaers, D., Chok, L., Bachli, Eb, Bettex, D., Cottini, Sr, Keller, E., Maggiorini, M., Schuepbach, R., Stiphout, C., Grevelink, M., Vaneker, I., Ruijter, A., Buise, M., Tena, Sa, Barrachina, Lg, Portillo, Jh, Aznar, Gp, Campos, Lm, Sellés, Md, Tomás, Ma, Muncharaz, Ab, Skinner, L., Monsalvo, S., Olavarria, E., Stümpfle, R., Na, Sj, Park, J., Chung, Cr, Suh, Gy, Yang, Jh, Witter, T., Brousseau, C., Butler, Mb, Erdogan, M., Dougall, Pc, Green, Rs, Abbott, Te, Torrance, Hd, Cron, N., Vaid, N., Emmanuel, J., Siddiqui, Ss, Prabu, N., Chaudhari, Hk, Patil, Vp, Divatia, Jv, Solanki, S., Kulkarni, Ap, Gutierrez, La, Brasseur, A., Hempel, D., Stauffert, N., Recker, F., Schröder, T., Reusch, S., Schleifer, J., Breitkreutz, R., Sjövall, F., Møller, Mh, Moraes, Rb, Borges, Fk, Guillen, Ja, Zabaletta, Wj, Pics- Hcpa, Programa Intrahospitalar Combate À Sepse Do Hospital Clínicas Porto Alegre, Ruiz-Ramos, J., Marqués-Miñana, MR, Sosa, M., Concha, P., Menendez, R., Ramírez, Cs, Santana, Mc, Balcázar, Lc, Escalada, Sh, Viera, Ma, Vázquez, Cf, Díaz, Jj, Campelo, Fa, Monroy, Ns, Santana, Ps, Santana, Sr, Gutiérrez-Pizarraya, A., Garnacho-Montero, J., Martin, C., Mainardi, Jl, Cholley, B., Hubbard, A., Frontera, Pr, Vega, Lm, Miguelena, Pr, Usón, Mc, López, Ar, Clemente, Ea, Ibañes, Pg, Aguilar, Al, Palomar, M., Olaechea, P., Uriona, S., Vallverdu, M., Catalan, M., Aragon, C., Lerma, Fa, Envin-Helics, Study Group, Bassi, Gl, Xiol, Ea, Senussi, T., Idone, Fa, Motos, A., Travierso, C., Fernández-Barat, L., Amaro, R., Hua, Y., Ranzani, Ot, Bobi, Q., Rigol, M., Torres, A., Fernández, If, Soler, Ea, Vera, Ap, Pastor, Ee, Hernandis, V., Ros Martínez, J., Rubio, Rj, Torner, Mm, Brugger, Sc, Eroles, Aa, Moles, Si, Cabello, Jt, Schoenenberger, Ja, Casals, Xn, Vidal, Mv, Garrido, Bb, Martinez, Mp, Mirabella, L., Cotoia, A., Tullo, L., Stella, A., Di Bello, F., Di Gregorio, A., Dambrosio, M., Cinnella, G., Ramirez, Jr, Takahashi, H., Kazutoshi, F., Okada, Y., Oobayashi, W., Naito, T., Baidya, Dk, Maitra, S., Anand, Rk, Ray, Br, Arora, Mk, Ruffini, C., Rota, L., Corona, A., Sesana, G., Ravasi, S., Catena, E., Naumann, Dn, Mellis, C., Husheer, Sl, Bishop, J., Midwinter, Mj, Hutchings, S., Manca, T., Ramelli, A., Nicolini, F., Gherli, T., Vezzani, A., Young, A., Carmona, Af, Santiago, Ai, Guillamon, Ln, Delgado, Mj, Delgado-Amaya, M., Curiel-Balsera, E., Rivera-Romero, L., Carrero-Gómez, F., Aguayo-Dehoyos, E., Ariam, Registry Of Adult Cardiac Surgery, Healey, Aj, Cameron, C., Jiao, Lr, Pérez, A., Martin, S., Del Moral, Ol, Toval, S., Rico, J., Aldecoa, C., Oguzhan, K., Demirkiran, O., Kirman, M., Bozbay, S., Kosuk, Me, Asyralyyeva, G., Dilek, M., Duzgun, M., Telli, S., Aydin, M., Yilmazer, F., Hodgson, Le, Dimitrov, Bd, Stubbs, C., Venn, R., Vedage, D., Shawaf, S., Naran, P., Sirisena, N., Kinnear, J., Londoño, Jg, Cardenas, Cl, Ginés, As, Gubianas, Cm, Sánchez, Ec, Sirvent, Jm, Panafidina, V., Shlyk, I., Ilyina, V., Judickas, S., Kezyte, G., Urbanaviciute, I., Serpytis, M., Gaizauskas, E., Sipylaite, J., Sprung, Cl, Munteanu, G., Morales, Rc, Kasdan, H., Volker, T., Reiter, A., Cohen, Y., Himmel, Y., Meissonnier, J., Banderas-Bravo, Me, Gómez-Jiménez, C., García-Martínez, Mv, Martínez-Carmona, Jf, Fernández-Ortega, Jf, O Dwyer, Mj, Starczewska, M., Wilks, M., Rapid Diagnosis of Infections in the Critically Ill Team, Torsvik, M., Gustad, Lt, Bangstad, Il, Vinje, Lj, Damås, Jk, Solligård, E., Mehl, A., Tsunoda, M., Kang, M., Saito, M., Saito, N., Akizuki, N., Namiki, M., Takeda, M., Yuzawa, J., Yaguchi, A., Tokyo Womens Medical University, Tsirigotis, P., Chondropoulos, S., Theodorakopoulou, M., Stamouli, M., Gkirkas, K., Dimopoulou, Ik, Makiko, S., Akiduki, N., Preau, S., Ambler, M., Sigurta, A., Saeed, S., Jochmans, S., Chelly, J., Vong, Lv, Sy, O., Serbource-Goguel, J., Rolin, N., Weyer, Cm, Abdallah, Ri, Adrie, C., Vinsonneau, C., Monchi, M., Mayr, U., Huber, W., Karsten, E., Lahmer, T., Thies, P., Henschel, B., Fischer, G., Schmid, Rm, Naz, I., Yaman, G., Kou, Ps, Lozano, Ja, Sánchez, Pc, Francioni, Je, Ferrón, Fr, Simón, Jm, Riad, Z., Mezidi, M., Aublanc, M., Perinel, S., Lissonde, F., Louf-Durier, A., Yonis, H., Tapponnier, R., Louis, B., Guérin, C., Plug, Working Group, Marmanidou, K., Oikonomou, M., Loizou, C., Somhorst, P., Hayashi, K., Hirayama, T., Yumoto, T., Tsukahara, K., Iida, A., Nosaka, N., Sato, K., Ugawa, T., Nakao, A., Ujike, Y., Hirohata, S., Mojoli, F., Torriglia, F., Giannantonio, M., Orlando, A., Bianzina, S., Mongodi, S., Pozzi, M., Iotti, Ga, Braschi, A., Jansen, D., Gadgil, S., Doorduin, J., Roesthuis, L., Heunks, Lm, Chen, Gq, Sun, Xm, He, X., Yang, Yl, Shi, Zh, Xu, M., Zhou, Jx, Pereira, Sm, Tucci, MR, Tonelotto, Bf, Simoes, Cm, Morais, Cc, Pompeo, Ms, Kay, Fu, Amato, Mb, Vieira, Je, Suzuki, S., Mihara, Y., Hikasa, Y., Okahara, S., Morimatsu, H., Okayama Research Investigation Organizing Network (ORION)investigators, Kwon, Hm, Moon, Yj, Lee, Sh, Jung, Kw, Shin, Wj, Jun, Ig, Song, Jg, Hwang, Gs, Lee, S., Jung, K., Brianti, R., Fanzaghi, P., Tudor, Ba, Klaus, Da, Lebherz-Eichinger, D., Lechner, C., Schwarz, C., Bodingbauer, M., Seemann, R., Kaczirek, K., Fleischmann, E., Roth, Ga, Krenn, Cg, Malyshev, A., Sergey, S., Yoshitake, E., Kaneko, M., Tencé, N., Zaien, I., Wolf, M., Trouiller, P., Jacobs, Fm, Kelly, Jm, Veigas, P., Hollands, S., Min, A., Rizoli, S., Robles, Cm, Oca Sandoval, Ma, Tarabrin, O., Gavrychenko, D., Mazurenko, G., Tarabrin, P., Mendez, Mc, Orden, Va, Noval, Rl, Mccue, C., Gemmell, L., Luján, J., Villa, P., Llorente, B., Molina, R., Alcázar, L., Juanas, Ca, Rogero, S., Pascual, T., Cambronero, Ja, Almudévar, Pm, Domínguez, Jp, Castañeda, Dp, Lucendo, Ap, Rivas, Rf, Villamizar, Pr, Javadpour, S., Kalani, N., Amininejad, T., Jamali, S., Sobhanian, S., Laurent, A., Bonnet, M., Rigal, R., Aslanian, P., Hebert, P., Capellier, G., Ps-Icu, Group, Contreras, MR, Mejías, Cr, Ruiz, Fc, Lombardo, Md, Perez, Jc, Hoyos, Ea, Estella, A., Viciana, R., Fontaiña, Lp, Rico, T., Madueño, Vp, Recuerda, M., Fernández, L., Bonet, S., Mazo, C., Rubiera, M., Ruiz-Rodríguez, Jc, Gracia, Rm, Espinel, E., Pont, T., Kotsopoulos, A., Jansen, N., Abdo, Wf, Gopcevic, A., Gavranovic, Z., Vucic, M., Glogoski, Mz, Penavic, Lv, Horvat, A., Martin-Villen, L., Egea-Guerero, Jj, Revuelto-Rey, J., Aldabo-Pallas, T., Correa-Chamorro, E., Gallego-Corpa, Ai, Granados, Pr, Faivre, V., Wildenberg, L., Huot, B., Lukaszewicz, Ac, Simsir, M., Mengelle, C., Payen, D., La Fuente, Mv, Almudena, Pm, Muñoz, Jj, Abellan, An, Lucendo, Ma, Perez, Lp, Dominguez, Jp, Wee, S., Ong, C., Lau, Yh, Wong, Y., Olea-Jiménez, V., Mora-Ordóñez, Jm, Muñoz-Muñoz, Jl, Vallejo-Báez, J., Daga-Ruiz, D., Lebrón-Gallardo, M., Rialp, G., Raurich, Jm, Morán, I., Martín, Mc, Heras, G., Mas, A., Vallverdú, I., Hraiech, S., Bourenne, J., Guervilly, C., Forel, Jm, Adda, M., Sylla, P., Mouaci, A., Gainnier, M., Papazian, L., Bauer, Pr, Kumbamu, A., Wilson, Me, Pannu, Jk, Egginton, Js, Kashyap, R., Gajic, O., Yoshihiro, S., Sakuraya, M., Hirata, A., Kawamura, N., Tsutui, T., Yoshida, K., Hashimoto, Y., Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Chang, Ch, Hu, Hc, Chiu, Lc, Hung, Cy, Li, Sh, Kao, Kc, Sibley, S., Drover, J., D Arsigny, C., Parker, C., Howes, D., Moffatt, S., Erb, J., Ilan, R., Messenger, D., Ball, I., Harrison, M., Ridi, S., Andrade, Ah, Costa, Rc, Souza, Va, Gonzalez, V., Amorim, V., Rolla, F., Filho, Ca, Miranda, R., Atchasiri, S., Buranavanich, P., Wathanawatthu, T., Suwanpasu, S., Bureau, C., Rolland-Debord, C., Poitou, T., Clavel, M., Perbet, S., Kouatchet, A., Similowski, T., Demoule, A., Diaz, P., Nunes, J., Escórcio, S., Silva, G., Chaves, S., Jardim, M., Câmara, M., Fernandes, N., Duarte, R., Jardim, Jj, Pereira, Ca, Nóbrega, Jj, Chen, Cm, Lai, Cc, Cheng, Kc, Chou, W., Lee, Sj, Cha, Ys, Lee, Wy, Onodera, M., Nakataki, E., Oto, J., Imanaka, H., Nishimura, M., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Akalaev, R., Parpibaev, F., Antonucci, E., Rossini, P., Gandolfi, S., Montini, E., Orlando, S., Nes, M., Karachi, F., Hanekom, S., Pereira, Uv, Parkin, Ms, Moore, M., Carvalho, Kv, Min, Hj, Kim, Hj, Choi, Yy, Lee, Ey, Song, I., Kim, Dj, E, Yy, Kim, Jw, Park, Js, Lee, Jh, Suh, Jw, Jo, Yh, Ferrero-Calleja, J., Merino-Vega, D., González-Jiménez, Ai, Sigcha, Ms, Hernández-Tejedor, A., Martin-Vivas, A., Gabán-Díez, Á, Luna, Rr, La Calle-Pedrosa, N., Temprano-Gómez, I., Afonso-Rivero, D., Pellin-Ariño, Ji, Algora-Weber, A., Fumis, Rr, Ferraz, Ab, Junior, Jm, Kirca, H., Cakin, O., Unal, M., Mutlu, H., Ramazanoglu, A., Cengiz, M., Nicolini, Ea, Pelisson, Fg, Nunes, Rs, Da Silva, Sl, Carreira, Mm, Bellissimo-Rodrigues, F., Ferez, Ma, Basile-Filho, A., Chao, Hc, Chen, L., Hravnak, M., Clermont, G., Pinsky, M., Dubrawski, A., Varas, Jl, Montero, Rm, Sánchez-Elvira, La, Díaz, Pv, Delgado, Cp, Ruiz, Bl, Guerrero, Ap, Galache, Ja, Sherif, H., Hassanin, H., El Hossainy, R., Samy, W., Ly, H., David, H., Burtin, P., Charpentier, C., Barral, M., Courant, P., Fournel, E., Gaide-Chevronnay, L., Durand, M., Albaladejo, P., Payen, Jf, Chavanon, O., Ortiz, Ab, Pozzebon, S., Fumagalli, F., Scala, S., Affatato, R., Maglie, M., Zani, D., Novelli, D., Marra, C., Luciani, A., Luini, M., Letizia, T., Pravettoni, D., Staszewsky, L., Belloli, A., Di Giancamillo, M., Scanziani, E., Kye, Yc, Yu, Km, Babini, G., Grassi, L., Reinikainen, M., Skrifvars, M., Kappler, F., Blobner, M., Schaller, Sj, Roasio, A., Costanzo, E., Cardellino, S., Fontana, V., Park, M., You, Km, Ko, Sb, Beane, A., Thilakasiri, Mc, Silva, Ap, Stephens, T., Sigera, Cs, Athapattu, P., Jayasinghe, S., Padeniya, A., Haniffa, R., Sáez, Vc, Ruiz-Ruano, Rdel, González, As, Kunze-Szikszay, N., Wand, S., Klapsing, P., Wetz, A., Heyne, T., Schwerdtfeger, K., Troeltzsch, M., Bauer, M., Quintel, M., Moerer, O., Cook, Dj, Rutherford, Wb, Scales, Dc, Adhikari, Nk, Cuthbertson, Bh, Suzuki, T., Fushimi, K., Iwamoto, M., Nakagawa, S., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, Mw, Romero, Dg, Padilla, Ys, Kleinpell, R., Chouris, I., Radu, V., Stougianni, M., Lavrentieva, A., Lagonidis, D., Price, Rd, Day, A., Arora, N., Henderson, Ma, Hickey, S., Costa, Mi, Carvalho, Jp, Gomes, Aa, Mergulhão, Pj, Chan, Kk, Maghsoudi, B., Tabei, Sh, Sabetian, G., Tabatabaei, Hr, Akbarzadeh, A., Student Research Committee - Shiraz University of Medical Sciences, Saigal, S., Pakhare, A., Joshi, R., Pattnaik, Sk, Ray, B., Rousseau, Af, Michel, L., Bawin, M., Cavalier, E., Reginster, Jy, Damas, P., Bruyere, O., Zhou, Jc, Cauwenberghs, H., Backer, A., Neels, H., Deblier, I., Berghmans, J., Himpe, D., Barea-Mendoza, Ja, Portillo, Ip, Fernández, Mv, Gigorro, Rg, Vela, Jl, Mateos, Hm, Alves, Sc, Varas, Gm, Rodriguez-Biendicho, A., Carreño, Er, González, Jc, Yang, Js, Lin, Kl, Choi, Yj, Yoon, Sz, Gordillo-Brenes, A., Fernandez-Zamora, Md, Herruzo-Aviles, A., Garcia-Delgado, M., Hinojosa-Perez, R., ARIAM-ANDALUCIA, Pascual, Oa, Pérez, Ag, Fernández, Pa, Amor, Ll, Albaiceta, Gm, Calvo, Sa, Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Tseng, Cj, Bertini, P., Sanctis, F., Guarracino, F., Baldassarri, R., Buitinck, Sh, Voort, Ph, Tsunano, Y., Izawa, M., Tane, N., Ghosh, S., Gupta, A., Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, Nd, Mukherjee, Dn, Agarwal, Lk, Mandal, K., Balsera, B., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, Ge, Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., La Torre, Ma, Torres, E., Bogossian, E., Nouer, Sa, Salgado, Dr, Jiménez, Gj, Gaite, Fb, Martínez, Mp, Doganci, M., Izdes, S., Besevli, Sg, Alkan, A., Kayaaslan, B., Penichet, Sm, López, Ma, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Dimitroulakis, K., Ferré, A., Guillot, M., Teboul, Jl, Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Prīdāne, S., Sabeļņikovs, O., Bianchi, I., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Karbing, Ds, Gioia, A., Moro, F., Corte, Fd, Mauri, T., Rees, Se, Plug working group, Petrova, Mv, Mohan, R., Butrov, Av, Beeharry, Sd, Vatsik, Mv, Sakieva, Fi, Gobert, F., Fernandez, R., Labaune, Ma, Burle, Jf, Barbier, J., Vincent, B., Cleyet, M., Shinotsuka, Cr, Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, Ma, Rodrigues, Nj, Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., E Silva, Zc, Lopes, Ja, Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Yamazaki, A., Ganuza, Ms, Molina, Ja, Martinez, Fh, Freile, Mt, Fernandez, Ng, Travieso, Pm, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, Jd, Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, Ag, Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, Ch, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, Jr, Kirwan, Cj, Gonzalez, Ca, Pinto, Jl, Orozco, V., Patiño, Ja, Garcia, Pk, Contreras, Km, Rodriguez, P., and Echeverri, Je
13. Increased ratio of P[v-a]CO 2 to C[a-v]O 2 without global hypoxia: the case of metformin-induced lactic acidosis.
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Andreis DT, Mallat J, Tettamanti M, Chiarla C, Giovannini I, Gatti S, and Protti A
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- Acidosis, Lactic diagnosis, Animals, Cell Hypoxia physiology, Disease Models, Animal, Hypoglycemic Agents administration & dosage, Lactic Acid blood, Metformin administration & dosage, Mitochondrial Diseases diagnosis, Swine, Acidosis, Lactic blood, Acidosis, Lactic chemically induced, Carbon Dioxide blood, Hypoglycemic Agents adverse effects, Metformin adverse effects, Mitochondrial Diseases blood, Mitochondrial Diseases chemically induced, Oxygen blood
- Abstract
The ratio of venoarterial CO
2 tension to arteriovenous O2 content difference (P[v-a]CO2 /C[a-v]O2 ) increases when lactic acidosis is due to inadequate oxygen supply (hypoxia); we aimed to verify whether it also increases when lactic acidosis develops because of mitochondrial dysfunction (dysoxia) with constant oxygen delivery. Twelve anaesthetised, mechanically ventilated pigs were intoxicated with IV metformin (4.0 to 6.4 g over 2.5 to 4.0 h). Saline and norepinephrine were used to preserve oxygen delivery. Lactate and P[v-a]CO2 /C[a-v]O2 were measured every one or two hours (arterial and mixed venous blood). During metformin intoxication, lactate increased from 0.8 (0.6-0.9) to 8.5 (5.0-10.9) mmol/l (p < 0.001), even if oxygen delivery remained constant (from 352 ± 78 to 343 ± 97 ml/min, p = 0.098). P[v-a]CO2 /C[a-v]O2 increased from 1.6 (1.2-1.8) to 2.3 (1.9-3.2) mmHg/ml/dl (p = 0.004). The intraclass correlation coefficient between lactate and P[v-a]CO2 /C[a-v]O2 was 0.72 (p < 0.001). We conclude that P[v-a]CO2 /C[a-v]O2 increases when lactic acidosis is due to dysoxia. Therefore, a high P[v-a]CO2 /C[a-v]O2 may not discriminate hypoxia from dysoxia as the cause of lactic acidosis., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2021
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14. Inhaled nitric oxide in mechanically ventilated patients with COVID-19.
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Ferrari M, Santini A, Protti A, Andreis DT, Iapichino G, Castellani G, Rendiniello V, Costantini E, and Cecconi M
- Abstract
Competing Interests: Declaration of Competing Interest Authors declare no conflict of interest for this manuscript.
- Published
- 2020
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15. Antithrombin During Extracorporeal Membrane Oxygenation in Adults: National Survey and Retrospective Analysis.
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Iapichino GE, Protti A, Andreis DT, Panigada M, Artoni A, Novembrino C, Pesenti A, and Gattinoni L
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- Adult, Female, Humans, Male, Partial Thromboplastin Time, Retrospective Studies, Thrombosis etiology, Thrombosis prevention & control, Anticoagulants therapeutic use, Antithrombins blood, Antithrombins therapeutic use, Extracorporeal Membrane Oxygenation adverse effects, Heparin therapeutic use
- Abstract
The impact of antithrombin replacement during extracorporeal membrane oxygenation (ECMO) in adults remains unclear. This work comprises a survey, showing that antithrombin is routinely supplemented in many Italian ECMO-Centers, and a retrospective analysis on 66 adults treated with veno-venous ECMO and unfractionated heparin at our Institution. Twenty-four to 72 h after the beginning of ECMO, antithrombin activity was ≤70% in 47/66 subjects and activated partial thromboplastin time (aPTT) ratio was <1.5 in 20/66 subjects. Activated partial thromboplastin time ratio <1.5 was associated not with lower antithrombin activity (61 ± 17 vs. 63 ± 22%; p = 0.983) but with higher circulating level of C-reactive protein (23 ± 8 vs. 11 ± 9 mg/dl; p < 0.001). In 34 subjects who received antithrombin concentrate, antithrombin activity increased (from 54 ± 9 to 84 ± 13%; p < 0.001); the proportion of subjects with aPTT ratio ≥1.5 increased (from 21/34 [62%] to 31/34 [91%]; p = 0.004); heparin dosage remained constant (from 19 ± 7 to 19 ± 6 IU/kg/h; p = 0.543); and C-reactive protein decreased (from 17 ± 10 to 13 ± 9 mg/dl; p = 0.013). Among those with aPTT ratio <1.5, aPTT ratio remained <1.5 in 3 out of 13 subjects. Antithrombin is frequently supplemented during veno-venous ECMO although low antithrombin activity does not constantly impede, and antithrombin replacement does not constantly ensure, reaching the target aPTT ratio. Inflammation possibly affects the individual response to heparin.
- Published
- 2019
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16. Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum.
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Andreis DT and Singer M
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- Cardiovascular System drug effects, Catecholamines physiology, Critical Illness, Homeostasis drug effects, Humans, Nervous System drug effects, Catecholamines pharmacology, Shock, Septic drug therapy
- Abstract
Catecholamines are endogenous neurosignalling mediators and hormones. They are integral in maintaining homeostasis by promptly responding to any stressor. Their synthetic equivalents are the current mainstay of treatment in shock states to counteract myocardial depression and/or vasoplegia. These phenomena are related in large part to decreased adrenoreceptor sensitivity and altered adrenergic signalling, with resultant vascular and cardiomyocyte hyporeactivity. Catecholamines are predominantly used in supraphysiological doses to overcome these pathological consequences. However, these adrenergic agents cause direct organ damage and have multiple 'off-target' biological effects on immune, metabolic and coagulation pathways, most of which are not monitored or recognised at the bedside. Such detrimental consequences may contribute negatively to patient outcomes. This review explores the schizophrenic 'Jekyll-and-Hyde' characteristics of catecholamines in critical illness, as they are both necessary for survival yet detrimental in excess. This article covers catecholamine physiology, the pleiotropic effects of catecholamines on various body systems and pathways, and potential alternatives for haemodynamic support and adrenergic modulation in the critically ill.
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- 2016
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17. Role of Strain Rate in the Pathogenesis of Ventilator-Induced Lung Edema.
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Protti A, Maraffi T, Milesi M, Votta E, Santini A, Pugni P, Andreis DT, Nicosia F, Zannin E, Gatti S, Vaira V, Ferrero S, and Gattinoni L
- Subjects
- Animals, Functional Residual Capacity physiology, Humans, Lung Compliance physiology, Pulmonary Edema physiopathology, Stress, Mechanical, Swine, Tidal Volume physiology, Ventilator-Induced Lung Injury physiopathology, Pulmonary Edema etiology, Respiration, Artificial adverse effects, Respiratory Mechanics physiology, Ventilator-Induced Lung Injury etiology
- Abstract
Objective: Lungs behave as viscoelastic polymers. Harms of mechanical ventilation could then depend on not only amplitude (strain) but also velocity (strain rate) of lung deformation. Herein, we tested this hypothesis., Design: Laboratory investigation., Setting: Animal unit., Subjects: Thirty healthy piglets., Interventions: Two groups of animals were ventilated for 54 hours with matched lung strains (ratio between tidal volume and functional residual capacity) but different lung strain rates (ratio between strain and inspiratory time). Individual strains ranged between 0.6 and 3.5 in both groups. Piglets ventilated with low strain rates had an inspiratory-to-expiratory time ratio of 1:2-1:3. Those ventilated with high strain rates had much lower inspiratory-to-expiratory time ratios (down to 1:9). Respiratory rate was always 15 breaths/min. Lung viscoelastic behavior, with ventilator setting required per protocol, was "quantified" as dynamic respiratory system hysteresis (pressure-volume loop [in Joules]) and stress relaxation (airway pressure drop during an end-inspiratory pause [in cm H2O]). Primary outcome was the occurrence of pulmonary edema within 54 hours., Measurements and Main Results: On average, the two study groups were ventilated with well-matched strains (2.1 ± 0.9 vs 2.1 ± 0.9; p = 0.864) but different strain rates (1.8 ± 0.8 vs 4.6 ± 1.5 s; p < 0.001), dynamic respiratory system hysteresis (0.6 ± 0.3 vs 1.4 ± 0.8 J; p = 0.001), and stress relaxation (3.1 ± 0.9 vs 5.0 ± 2.3 cm H2O; p = 0.008). The prevalence of pulmonary edema was 20% among piglets ventilated with low strain rates and 73% among those ventilated with high strain rates (p = 0.010)., Conclusions: High strain rate is a risk factor for ventilator-induced pulmonary edema, possibly because it amplifies lung viscoelastic behavior.
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- 2016
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18. Lung anatomy, energy load, and ventilator-induced lung injury.
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Protti A, Andreis DT, Milesi M, Iapichino GE, Monti M, Comini B, Pugni P, Melis V, Santini A, Dondossola D, Gatti S, Lombardi L, Votta E, Carlesso E, and Gattinoni L
- Abstract
Background: High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP is protective per se or indirectly., Methods: In 76 pigs (22 ± 2 kg), we examined the lower and upper limits (30.9-59.7 mL/kg) of inspiratory capacity by computed tomography (CT) scan at 45 cmH2O pressure. The pigs underwent a 54-h mechanical ventilation with a global strain ((tidal volume (dynamic) + PEEP volume (static))/functional residual capacity) from 0.45 to 5.56. The dynamic strain ranged from 18 to 100 % of global strain. Twenty-nine pigs were ventilated with end-inspiratory volumes below the lower limit of inspiratory capacity (group "Below"), 38 within (group "Within"), and 9 above (group "Above"). VILI was defined as death and/or increased lung weight., Results: "Below" pigs did not develop VILI; "Within" pigs developed lung edema, and 52 % died before the end of the experiment. The amount of edema was significantly related to dynamic strain (edema 188-153 × dynamic strain, R (2) = 0.48, p < 0.0001). In the "Above" group, 66 % of the pigs rapidly died but lung weight did not increase significantly. In pigs ventilated with similar tidal volume adding PEEP significantly increased mortality., Conclusions: The threshold for VILI is the lower limit of inspiratory capacity. Below this threshold, VILI does not occur. Within these limits, severe/lethal VILI occurs depending on the dynamic component. Above inspiratory capacity stress at rupture may occur. In healthy lungs, PEEP is protective only if associated with a reduced tidal volume; otherwise, it has no effect or is harmful.
- Published
- 2015
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19. High positive end-expiratory pressure: only a dam against oedema formation?
- Author
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Protti A, Andreis DT, Iapichino GE, Monti M, Comini B, Milesi M, Zani L, Gatti S, Lombardi L, and Gattinoni L
- Subjects
- Animals, Hemodynamics, Lung diagnostic imaging, Lung pathology, Lung physiopathology, Organ Size, Pulmonary Edema pathology, Pulmonary Edema physiopathology, Swine, Tidal Volume, Tomography, X-Ray Computed, Positive-Pressure Respiration methods, Pulmonary Edema prevention & control
- Abstract
Introduction: Healthy piglets ventilated with no positive end-expiratory pressure (PEEP) and with tidal volume (VT) close to inspiratory capacity (IC) develop fatal pulmonary oedema within 36 h. In contrast, those ventilated with high PEEP and low VT, resulting in the same volume of gas inflated (close to IC), do not. If the real threat to the blood-gas barrier is lung overinflation, then a similar damage will occur with the two settings. If PEEP only hydrostatically counteracts fluid filtration, then its removal will lead to oedema formation, thus revealing the deleterious effects of overinflation., Methods: Following baseline lung computed tomography (CT), five healthy piglets were ventilated with high PEEP (volume of gas around 75% of IC) and low VT (25% of IC) for 36 h. PEEP was then suddenly zeroed and low VT was maintained for 18 h. Oedema was diagnosed if final lung weight (measured on a balance following autopsy) exceeded the initial one (CT)., Results: Animals were ventilated with PEEP 18 ± 1 cmH2O (volume of gas 875 ± 178 ml, 89 ± 7% of IC) and VT 213 ± 10 ml (22 ± 5% of IC) for the first 36 h, and with no PEEP and VT 213 ± 10 ml for the last 18 h. On average, final lung weight was not higher, and actually it was even lower, than the initial one (284 ± 62 vs. 347 ± 36 g; P = 0.01)., Conclusions: High PEEP (and low VT) do not merely impede fluid extravasation but rather preserve the integrity of the blood-gas barrier in healthy lungs.
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- 2013
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20. Lung stress and strain during mechanical ventilation: any difference between statics and dynamics?
- Author
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Protti A, Andreis DT, Monti M, Santini A, Sparacino CC, Langer T, Votta E, Gatti S, Lombardi L, Leopardi O, Masson S, Cressoni M, and Gattinoni L
- Subjects
- Acute Lung Injury diagnostic imaging, Animals, Hemodynamics, Pulmonary Edema diagnostic imaging, Pulmonary Gas Exchange, Radiography, Respiration, Artificial methods, Respiratory Mechanics, Stress, Physiological, Swine, Tidal Volume, Acute Lung Injury etiology, Acute Lung Injury pathology, Disease Models, Animal, Pulmonary Edema etiology, Pulmonary Edema pathology, Respiration, Artificial adverse effects
- Abstract
Objective: Tidal volume (VT) and volume of gas caused by positive end-expiratory pressure (VPEEP) generate dynamic and static lung strains, respectively. Our aim was to clarify whether different combinations of dynamic and static strains, resulting in the same large global strain, constantly produce lung edema., Design: Laboratory investigation., Setting: Animal unit., Subjects: Twenty-eight healthy pigs., Interventions: After lung computed tomography, 20 animals were ventilated for 54 hours at a global strain of 2.5, either entirely dynamic (VT 100% and VPEEP 0%), partly dynamic and partly static (VT 75-50% and VPEEP 25-50%), or mainly static (VT 25% and VPEEP 75%) and then killed. In eight other pigs (VT 25% and VPEEP 75%), VPEEP was abruptly zeroed after 36-54 hours and ventilation continued for 3 hours., Measurements and Main Results: Edema was diagnosed when final lung weight (balance) exceeded the initial weight (computed tomography). Mortality, lung mechanics, gas exchange, pulmonary histology, and inflammation were evaluated. All animals ventilated with entirely dynamic strain (VT 825±424 mL) developed pulmonary edema (lung weight from 334±38 to 658±99 g, p<0.01), whereas none of those ventilated with mainly static strain (VT 237±21 mL and VPEEP 906±114 mL, corresponding to 19±1 cm H2O of positive end-expiratory pressure) did (from 314±55 to 277±46 g, p=0.65). Animals ventilated with intermediate combinations finally had normal or largely increased lung weight. Smaller dynamic and larger static strains lowered mortality (p<0.01), derangement of lung mechanics (p<0.01), and arterial oxygenation (p<0.01), histological injury score (p=0.03), and bronchoalveolar interleukin-6 concentration (p<0.01). Removal of positive end-expiratory pressure did not result in abrupt increase in lung weight (from 336±36 to 351±77 g, p=0.51)., Conclusions: Lung edema forms (possibly as an all-or-none response) depending not only on global strain but also on its components. Large static are less harmful than large dynamic strains, but not because the former merely counteracts fluid extravasation.
- Published
- 2013
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21. In vivo conditioning of acid-base equilibrium by crystalloid solutions: an experimental study on pigs.
- Author
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Langer T, Carlesso E, Protti A, Monti M, Comini B, Zani L, Andreis DT, Iapichino GE, Dondossola D, Caironi P, Gatti S, and Gattinoni L
- Subjects
- Analysis of Variance, Animals, Bicarbonates pharmacology, Capnography, Crystalloid Solutions, Hydrogen-Ion Concentration, Linear Models, Random Allocation, Ringer's Lactate, Sodium Chloride pharmacology, Swine, Acid-Base Equilibrium drug effects, Isotonic Solutions pharmacology
- Abstract
Purpose: Large infusion of crystalloids may induce acid-base alterations according to their strong ion difference ([SID]). We wanted to prove in vivo, at constant PCO(2), that if the [SID] of the infused crystalloid is equal to baseline plasma bicarbonate, the arterial pH remains unchanged, if lower it decreases, and if higher it increases., Methods: In 12 pigs, anesthetized and mechanically ventilated at PCO(2) ≈40 mmHg, 2.2 l of crystalloids with a [SID] similar to (lactated Ringer's 28.3 mEq/l), lower than (normal saline 0 mEq/l), and greater than (rehydrating III 55 mEq/l) baseline bicarbonate (29.22 ± 2.72 mEq/l) were infused for 120 min in randomized sequence. Four hours of wash-out were allowed between the infusions. Every 30 min up to minute 120 we measured blood gases, plasma electrolytes, urinary volume, pH, and electrolytes. Albumin, hemoglobin, and phosphates were measured at time 0 and 120 min., Results: Lactated Ringer's maintained arterial pH unchanged (from 7.47 ± 0.06 to 7.47 ± 0.03) despite a plasma dilution around 12%. Normal saline caused a reduction in pH (from 7.49 ± 0.03 to 7.42 ± 0.04) and rehydrating III induced an increase in pH (from 7.46 ± 0.05 to 7.49 ± 0.04). The kidney reacted to the infusion, minimizing the acid-base alterations, by increasing/decreasing the urinary anion gap, primarily by changing sodium and chloride concentrations. Lower urine volume after normal saline infusion was possibly due to its greater osmolarity and chloride concentration as compared to the other solutions., Conclusions: Results support the hypothesis that at constant PCO(2), pH changes are predictable from the difference between the [SID] of the infused solution and baseline plasma bicarbonate concentration.
- Published
- 2012
- Full Text
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