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1. Influence of temperature on the electrochemical coloration process and properties of the AISI 304 and 430 colored stainless steel

Author: J.L. Silva, Andreia Rocha Canella Carneiro, Geovane Martins Castro, Eduardo Henrique Martins Nunes, Vanessa de Freitas Cunha Lins, and Rosa Maria Rabelo Junqueira
Subjects: Colored stainless steel, Nanoindentation, Wettability, Interference film, Nanohardness, Mining engineering. Metallurgy, TN1-997
Abstract: The influence of temperature on the speed of an electrochemical coloration process of AISI 304 and AISI 430 stainless steel was investigated in temperature ranging from 25 °C to 40 °C. The surface properties of the interference colored nanofilms obtained in both types of stainless steel substrates, were also evaluated. A higher coloring speed was observed for AISI 304. The coloring time to obtain a gold color decreased with increasing temperature for both steels. This effect was stronger on the AISI 430 substrate, with a decrease of 36.6% in the coloration time for the samples colored at 40 °C and 25 °C. The Arrhenius model was applied to estimate the equations of colored films growth rate. The films porous fractions evaluated by SEM were in the range of 27–29%, without relevant variation with the coloring temperature. The nanohardness of the conjugated film-substrate obtained in a nanoindenter coupled to an AFM shows lower values than the uncolored substrates, and this reduction is more significant for the films grown on the AISI 430 ferritic specimens. The wettability of the surface to water and oil increased after coloring. The amplification effect of the hydrophilic effect can be associated with the increased AFM nanorugosity values.
Published: 2022
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2. Análise da variabilidade de medição interoperador de parâmetros pré e pós-operatórios em olhos com implante de lente de colâmero implantável (ICL) através da tomografia de coerência ótica do segmento anterior

Author: Bruno Pereira, Catarina Pereira, Catarina Lopes, Maria Narciso, Raquel Moura, Sara Silva, and Andreia Rocha
Subjects: Repetibilidade, Tomografia de coerência ótica, Segmento anterior, Vault, ICL, Medicine
Abstract: Introdução – As lentes ICL (Implantable Collamer Lens) são uma alternativa aos procedimentos refrativos mais convencionais. O seu implante pode desencadear complicações, que podem ser minimizadas se forem efetuadas medições pré e pós-operatórias fiáveis. O objetivo deste estudo é analisar a variabilidade interoperador das medições pré e pós-operatórias, utilizando imagens obtidas através de tomografia de coerência ótica do segmento anterior. Métodos – Utilizando o equipamento SD-OCT Spectralis®, dois ortoptistas mediram o diâmetro inter esporão escleral, o diâmetro pupilar e o vault, em 60 imagens de 30 olhos implantados com lentes ICL. Para a análise estatística foram utilizadas estatísticas descritivas, o teste t para o valor médio para amostras independentes, tendo-se ainda calculado o coeficiente de correlação intraclasse. Foram ainda construídos gráficos de dispersão de Bland-Altman Plot. Resultados – Avaliando o coeficiente de correlação intraclasse, todas as medições em estudo apresentaram uma concordância excelente entre os dois operadores. No teste t observaram-se diferenças estatisticamente significativas entre os dois operadores, apenas para as medições do vault, com possível impacto clínico. Quanto às medidas de diâmetro inter esporão escleral, apesar da ausência de diferenças estatisticamente significativas, existiram algumas diferenças com significância clínica que devem ser corrigidas no futuro. Conclusões – Diferenças de medição interoperador devem ser avaliadas estatisticamente, mas também clinicamente, pois apesar da ausência de diferenças estatisticamente significativas o seu impacto clínico deve ser avaliado, ponderado e, quando necessário, corrigido.
Published: 2022
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3. Guia de apoio para avaliação de sintomalogia em doentes com síndromes mieloproliferativos através da aplicação da escala mpn-10

Author: Andreia Rocha, Cláudia Ricou, Elisabete Pereira, Elisabete Valério, Júan Sanchez, M. Jorge Freitas, Márcia Caeiro, Maria Sarmento, Marta Duarte, Sandra Ponte, and Sónia Frias
Subjects: Neoplasias Mieloproliferativas, Sintomas, MPN-10, Nursing, RT1-120, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: As neoplasias mieloproliferativas cromossoma Filadélfia negativo (PH-), em particular a Mielofibrose, Policitemia Vera e Trombocitemia Essencial, representam um grupo heterogéneo de distúrbios do sistema hematopoiético associado a sintomas debilitantes com consequente redução da qualidade de vida e impacto negativo nas atividades de vida diária dos doentes. Focados nestes aspectos, algumas unidades hospitalares portuguesas iniciaram a monitorização e avaliação sistemática dos sintomas destes doentes tomando por base a escala Myeloproliferative Neoplasm Symptom Assessment Form, Total Symptom Score (MPN-SAF TSS), conforme recomendado pelas guidelines da National Comprehensive Cancer Network (NCCN). A escala, validada para a língua portuguesa, tem sido aplicada com o apoio das equipas de enfermagem destes centros. Os profissionais de saúde envolvidos estiveram reunidos, em modelo de Focus Group, para debater os principais desafios inerentes à utilização da escala MPN-10, na sequência do qual foi desenvolvido o presente guia. Foram identificados como aspetos mais relevantes na aplicação da escala: 1) ter em consideração que se trata de uma escala de auto-preenchimento; 2) a escala visa a avaliação do impacto do sintoma recorrendo a categorias numéricas e, 3) o profissional não deve remeter / induzir o doente para comparação com avaliações anteriores. Para facilitar a compreensão da escala e metodologia de preenchimento pelo doente foi desenvolvida informação adicional sobre cada um dos sintomas para utilização pelo profissional de saúde no momento de informação / esclarecimentos ao doente.
Published: 2018
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4. Bio&Med Search - A Platform to Help Health Professionals about Pharmacogenetics.

Author: Andreia Rocha, Joana Vilhena, Anabela Moreira Bernardino, Eugénia Moreira Bernardino, Alexandrino Gonçalves, and Rita M. T. Ascenso
Published: 2019
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5. Influence of temperature on the electrochemical coloration process and properties of the AISI 304 and 430 colored stainless steel

Author: Eduardo Nunes, Vanessa de Freitas Cunha Lins, Rosa Maria Rabelo Junqueira, Andreia Rocha Canella Carneiro, Geovane Martins Castro, and Jaqueline Lacerda da Silva
Subjects: Materials science, Colored stainless steel, Mining engineering. Metallurgy, Metallurgy, Interference film, Metals and Alloys, TN1-997, Electrochemistry, Nanoindentation, Surfaces, Coatings and Films, Biomaterials, Colored, Scientific method, Nanohardness, Ceramics and Composites, Wettability
Abstract: The influence of temperature on the speed of an electrochemical coloration process of AISI 304 and AISI 430 stainless steel was investigated in temperature ranging from 25 °C to 40 °C. The surface properties of the interference colored nanofilms obtained in both types of stainless steel substrates, were also evaluated. A higher coloring speed was observed for AISI 304. The coloring time to obtain a gold color decreased with increasing temperature for both steels. This effect was stronger on the AISI 430 substrate, with a decrease of 36.6% in the coloration time for the samples colored at 40 °C and 25 °C. The Arrhenius model was applied to estimate the equations of colored films growth rate. The films porous fractions evaluated by SEM were in the range of 27–29%, without relevant variation with the coloring temperature. The nanohardness of the conjugated film-substrate obtained in a nanoindenter coupled to an AFM shows lower values than the uncolored substrates, and this reduction is more significant for the films grown on the AISI 430 ferritic specimens. The wettability of the surface to water and oil increased after coloring. The amplification effect of the hydrophilic effect can be associated with the increased AFM nanorugosity values.
Published: 2022

6. Fragmentos de Caatinga são florística e estruturalmente similares?

Author: Leovandes Soares Silva, Andreia Rocha Martins, Thiago Alves dos Santos Garcia, Regina dos Santos Teixeira, and Natália Viveiros Salomão
Subjects: Atmospheric Science, Geophysics, Geography, Planning and Development, Computers in Earth Sciences, Earth-Surface Processes, General Environmental Science
Abstract: The increase in exploration has been changing the structure and diversity in the Caatinga fragments. The objective of this study was to evaluate the floristic composition, structure and similarity between caatinga fragments in the state of Piauí. Forty-two square plots were located 400 m2 (20 × 20m), divided into two areas, 20 plots in area I and 22 plots in area II. All living individuals with circumference at breast height (≥ 5 cm) were measured. In area I, 2,080 individuals were sampled distributed in 15 families, 34 genera and 43 species. The Shannon diversity index (H') was 2.77 nats.ind-1 and equability (J) 0.73. In area II, 1,275 individuals were measured in eight families, 20 genera and 26 species, the Shannon index (H') was 1,70 nats.ind-1, pielou's equability value 0,52. The Fabaceae family was the most representative in number of species. The two areas share few species six (9,5%), area I has the highest percentage of exclusive species 37 (58,7%) in relation to area II. The two areas have differences in floristic and structural parameters. Species diversity was considered low for normal pattern in Caatinga areas. Area I was higher than area II in density, number of families, species and diversity index, as demonstrated by the high diversity β found, are in different state of conservation and ecological succession.
Published: 2022
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7. Fragmentos de Caatinga são florística e estruturalmente similares?

Author: Silva, Leovandes Soares, primary, Martins, Andreia Rocha, additional, Garcia, Thiago Alves dos Santos, additional, Teixeira, Regina dos Santos, additional, and Salomão, Natália Viveiros, additional
Published: 2022
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8. Initial Invasive or Conservative Strategy for Stable Coronary Disease

Author: Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura 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Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C 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Hayes, Sebastian Sobczak, Senait Asier, Sergey A Sayganov, Seth I Sokol, Shaheen Pandie, Shaiful Azmi Yahaya, Shamir Mehta, Shao-Ping Nie, Sharad Chandra, Sharder Islam, Sharon Tai, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Sherron C Crook, Shigeyuki Nishimura, Shintaro Nakano, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shobana Ganesan, Shruti Pandey, Shuyang Zhang, Shweta Hande, Siddharth Gadage, Sik-Yin V Tan, Silvia Zottis Poletti, Silvia Riera, Silvia Valbuena, Simon Walsh, Simona Maspoli, Simone Savaris, Si-Ting Feng, So Yang Cho, Solomon Yakubov, Songlin Zhu, Songtao Wang, Sonia Guerrero, Sonika Gupta, Sonja Salinger Martinovic, Sonya Brons, Sorin Brener, Sothinathan Gurunathan, Souheil Saba, Soundarya Nayak, Sowjanya Reddy, Srinivasa Potluri, Sriram Sudarshan, Srun Kuanprasert, Stacie Van Oosterhout, Stamatios Lerakis, Stanley E Cobos, Stefan C Bertog, Stefan M Simović, Stefan Weikl, Stefano Di Marco, Stefano Provasoli, Stephanie A Tirado, Stephanie C Boer, Stephanie M Lane, Stephanie Ferket, Stephanie Kelly, Stephanie Wasmiller, Stephen H McKellar, Stephen P Hoole, Stephen Fremes, Stephen Preston, Steve Leung, Steven A Fein, Steven J Lindsay, Steven P Sedlis, Steven Giovannone, Steven Michael, Steven Weitz, Stijn van Vugt, Subhash Banerjee, Sudhir Naik, Suellen Hosino, Sukie Desire, Sukit Yamwong, Suku T Thambar, Sulagna Mookherjee, Suman Singh, Sundeep Mishra, Sunil Kumar Verma, Supap Kulthawong, Supatchara Khwakhong, Surendra Naik, Suresh Babu, Surin Woragidpoonpol, Suryaprakash Narayanappa, Susan Derbyshire, Susan Gent, Susan Mathus, Susan Milbrandt, Susan Moore, Susan Regan, Susan Stinson, Susan Webber, Susana Silva, Susanna Stevens, Susanne Gruensfelder, Suthara Aramcharoen, Suvarna Kolhe, Suzana Tavares, Suzanne Arnold, Suzanne Welsh, Svetlana Apostolovic, Swapna Kunhunny, Ta-Chuan Hung, Taissa Zappernick, Tali Sharir, Talita Silva, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarun K Mittal, Tatiana Trifonova, Tauane Bello Duarte, Tauqir Huk, Téodora Dutoiu, Terrance Chua, Terry Weyand, Thabitha Charles, Theodoros Kofidis, Theresa McCreary, Thierry Lefevre, Thippeekaa Arumairajah, Thitipong Tepsuwan, Thomas J Mulhearn, Thomas M Meyer, Thomas P Rocco, Thomas R Downes, Thomas Crain, Thomas Haldis, Thomas Mathew, Thomas Redick, Thounaojam Indira Devi, Thuraia Nageh, Tia Cauthren, Tiago Silva, Tiffany Little, Tijana Andric, Tina Harding, Titus Lau, Tiziana Formisano, Tiziano Moccetti, Tomasz Ciurus, Tomasz Mazurek, Tomasz Tarchalski, Toshiyuki Nagai, Tri Tran, Tricia Youn, Trish Tucker, Trudie Milner, Tuhina Bose, Tushar Kotecha, Udo Sechtem, Uma S Valeti, Umberto Cucchini, Umesh Badami, Upendra Kaul, V K Bahl, V S Narain, Valentina Casali, Valeria Godoy, Valerie Robesyn, Vamshi P Priya, Vandana Yadav, Vera McKinney, Veronica De Lenges, Veronica Tinnirello, Vicente Miro, Victor Navarro, Victoria Gumerova, Victoria Hernandez, Vidya Seeratan, Vijay Kumar, Vikentiy Y Kozulin, Viktoria Bulkley, Vilmar Veiga Jr, Vincent Setang, C P Vineeth, Virginai Pubull Nuñez, Virginia Fernández-Figares, Vitor Gomes, Viviana Gabriel, Viviane Dos Santos, Viviane Almeida, Vlad A Iliescu, Vladan Mudrenovic, Vladimir Dzavik, Vojislav L Giga, Walter Enrique Mogrovejo, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Warangkana Mekara, Wassim Nona, Wayne Old, Wayne Pennachi, Weerachai Nawarawong, Wei Chen, Wei Su, Weibing Xing, Wei-Ren Lan, Wenda Crawford, Wendy L Stewart, Wendy Drewes, Wenhua Lin, William B Abernethy, William D Salerno, William F Fearon, William Vergoni, William Weintraub, Winnie C Sia, Wlodzimierz J Musial, Xacobe Flores-Ríos, Xavier Garcia-Moll Marimon, Xi Su, Xiang Ma, Xiangqiong Gu, Xiao Wang, Xiaomei Li, Xiaowei Yao, Xin Fu, Xin Su, Xin Zeng, Xinchun Yang, Xiuhong Li, Xuehua Fang, Xutong Wang, Yaming Geng, Yan Yan, Yanek Pépin-Dubois, Yanfu Wang, Yang Wang, Yanmeng Tian, Yaping Huang, Yechen Han, Yesenia Zambrano, Yi-Hsuan Yang, Ying Tung Sia, Yining Yang, Yitong Ma, Yolayfi Peralta, Yongjian Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
Subjects: Male, Cardiac Catheterization, Computed Tomography Angiography, medicine.medical_treatment, Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary Angiography, ISCHEMIA Research Group, law.invention, Angina, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Cardiovascular Disease, Myocardial Revascularization, 030212 general & internal medicine, Coronary Artery Bypass, 11 Medical and Health Sciences, Cardiac catheterization, General Medicine, Middle Aged, humanities, Cardiovascular Diseases, Cardiology, Female, Human, medicine.medical_specialty, Ischemia, Article, 03 medical and health sciences, Geriatric cardiology, Percutaneous Coronary Intervention, General & Internal Medicine, Internal medicine, medicine, Humans, Angina, Unstable, Aged, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Bayes Theorem, medicine.disease, Heart failure, Quality of Life, business
Abstract: BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).
Published: 2020
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9. A intervenção cognitivo-comportamental mediada por uma aplicação móvel para a ansiedade social no apoio psicológico universitário

Author: Pratas, Carla Andreia Rocha de Oliveira, Pereira, Anabela Sousa, and Vagos, Paula Emanuel Rocha Martins
Subjects: Ansiedade social, mHealth, Terapia cognitivo-comportamental, Estudante universitário
Abstract: Nos últimos anos os serviços de apoio psicológico no ensino superior (SAPES) têm observado um aumento significativo de estudantes com perturbação mental, apresentando também uma elevada procura por parte dos estudantes e poucos recursos económicos, humanos e materiais para dar resposta. Consequentemente, os SAPES têm apresentado frequentes e longas listas de espera, tal como uma elevada sobrecarga dos seus psicólogos. A terapia cognitivo-comportamental (TCC) é a mais utilizada neste contexto e apesar da sua eficácia se encontrar bem estabelecida para um grande número de condições psicológicas apresenta também as suas limitações, como por exemplo, a por vezes reduzida adesão dos pacientes às tarefas de casa. Particularmente na ansiedade social, o tratamento psicológico é por vezes perspectivado com vergonha e ansiedade face ao medo de serem avaliados e sujeitos a escrutínio, afirmando-se como uma barreira ao tratamento. As intervenções mediadas por dispositivos móveis têm sido referidas na literatura como uma promissora solução tecnológica face a estas limitações, apresentado inúmeras vantagens. O actual projeto propôs-se assim a conceptualizar, desenvolver e avaliar uma intervenção cognitivo comportamental combinada com um dispositivo móvel para estudantes com ansiedade social. Para atingir os nossos objetivos realizamos vários estudos, a revisão da literatura indicou-nos que as intervenções psicológicas assistidas por dispositivos móveis são cada vez mais frequentes e a sua eficácia na redução de sintomatologia psicopatológica (e.g. stress, ansiedade e depressão), em estudantes universitários, tem sido demonstrada. Através de um estudo descritivo verificamos que os estudantes portugueses utilizam com frequência aplicações móveis e os estudantes em acompanhamento psicológico reportaram que esta poderia ser uma ferramenta útil e relevante, sugerindo aceitabilidade destas intervenções. Todos os estudantes identificados com ansiedade social reportaram interesse e referiram que adeririam caso a aplicação móvel existisse. As principais características numa aplicação móvel seriam a utilidade, conteúdo e privacidade, respectivamente. Os estudantes em contexto clínico deram primazia à segurança e privacidade. O desenvolvimento da aplicação envolveu uma equipa multidisciplinar, sendo que a usabilidade do primeiro protótipo foi testada e obteve resultados de usabilidade acima da média, no entanto, alguns módulos indicavam serem pouco intuitivos e de difícil compreensão. Por conseguinte, incluímos um especialista em design para optimizar a aplicação móvel ao nível do design interactivo. Em geral, obtivemos resultados de usabilidade superiores, com indicação de elevada satisfação com a aplicação móvel. Com o actual projeto concluímos que os estudantes parecem aceitar e aderir à aplicação móvel desenvolvida, indicando que as intervenções combinadas poderão se revelar uma solução promissora para a integração nos SAPES. In recent years, psychological support services in higher education (SAPES) observed a significant increase in students with mental disorders, such as a high demand from students and few economic, human and material resources to respond. Consequently, the SAPES have had frequent and long waiting lists, as well as a therapist caseload. Cognitive-behavioral therapy (CBT) is the most used therapy in this context and despite its efficacy being well established for a large number of psychological conditions, it also has its limitations, such as the sometimes reduced adherence of patients to homework assignments. Particularly in social anxiety, psychological treatment sometimes elicits shame and anxiety due to the fear of being evaluated and subjected to scrutiny, asserting itself as a barrier to treatment. Interventions mediated by mobile devices have been suggested by the scientific literature as a promising technological solution to respond to these limitations, with numerous advantages. Thus, the current project proposed to conceptualize, develop and evaluate a cognitive-behavioral intervention combined with a mobile device for students with social anxiety. To achieve our goals, we carried out several studies, the literature review indicated that psychological interventions assisted by mobile devices are increasingly frequent and their effectiveness in reducing psychopathological symptoms (eg stress, anxiety and depression) in university students has been demonstrated. Through a descriptive study, we verified that Portuguese students frequently use mobile applications and students undergoing psychological counseling reported that this could be a useful and relevant tool, suggesting acceptability of these interventions. All students identified with social anxiety reported interest and stated that they would join if the mobile application existed. The main features considered for a mobile application would be usefulness, content and privacy, respectively. Students in a clinical setting prioritized privacy and security. The development of the application involved a multidisciplinary team and the usability of the first prototype was tested and obtained usability results above average, however, some modules indicated that they were not very intuitive and difficult to understand. Therefore, we have included an interactive design specialist to optimize the mobile application to enhance interactive design. In general, we obtained superior usability results, with an indication of high satisfaction with the mobile application. With the current project we conclude that students seem to accept and adhere to the mobile application developed, indicating that the combined interventions could prove to be a promising solution for SAPES integration. Programa Doutoral em Psicologia
Published: 2022

10. Convalescent plasma for COVID-19 in hospitalised patients : an open-label, randomised clinical trial

Author: Sekine, Leo, Arns, Beatriz, Fabro, Bruna Rosa, Cipolat, Murillo Machado, Machado, Rafael Rahal Guaragna, Durigon, Edison Luiz, Parolo, Edino, Pellegrini, José Augusto Santos, Viana, Marina Verçoza, Schwarz, Patrícia, Lisboa, Thiago Costa, Dora, José Miguel Silva, Portich, Julia Plentz, Paz, Alessandra Aparecida, Silla, Lucia Mariano da Rocha, Balsan, Almeri Marlene, Schirmer, Felippe da Silva, Franz, Juliana Pires Marafon, Silveira, Luciana M. da, Breunig, Raquel Cristine, Petersen, Viviana, Sosnoski, Monalisa, Mesquita, Nanci Felix, Volpato, Fabiana Caroline Zempulski, Sganzerla, Daniel, Falavigna, Maicon, Rosa, Regis Goulart, Zavascki, Alexandre Prehn, Oliveira, Ana Claudia Tonelli de, Malaquias, Andreia Rocha, Silva, Ane Katiussa Siqueira Fröhlic da, Araujo, Anelise Bergmann, Araújo Antônia Cícera da Silva, Blos, Bruna, Cohen, Carolina Rodrigues, Borges, Cristiane Tavares, Rocha, Cristiano Rossa da, Speransa, Daniela Michelim Rodriguez, Oliveira, Delany da Silva, Rados, Dimitris Rucks Varvaki, Bonacina, Francine, Salton, Gabrielle Dias, Zucchetti, Giovana, Freitas, Isabel Cristina, Constante, Juliana Goncalves, Furlan, Juliana Monteiro, Kleber, Karine, Vieira, Laís Pelentier, Pires, Leonardo Martins, Röhsig, Liane Marise, Vargas, Luciana do Nascimento, Leão, Marize do Socorro Vulcão, Angeli, Melissa Helena, Seltenreich, Patricia Paim Ferreira, Silva, Patricia Santos da, Scheffel, Rafael Selbach, Boehm, Renata Eliane, Mello, Renato Gorga Bandeira de, and Souza, Thabyta Silva Franco de
Subjects: COVID-19
Abstract: Background: The effects of convalescent plasma (CP) therapy in hospitalised patients with coronavirus disease 2019 (COVID-19) remain uncertain. This study investigates the effect of CP on clinical improvement in these patients. Methods: This is an investigator-initiated, randomised, parallel arm, open-label, superiority clinical trial. Patients were randomly (1:1) assigned to two infusions of CP plus standard of care (SOC) or SOC alone. The primary outcome was the proportion of patients with clinical improvement 28 days after enrolment. Results: A total of 160 (80 in each arm) patients (66.3% critically ill, 33.7% severely ill) completed the trial. The median (interquartile range (IQR)) age was 60.5 (48–68) years; 58.1% were male and the median (IQR) time from symptom onset to randomisation was 10 (8–12) days. Neutralising antibody titres >1:80 were present in 133 (83.1%) patients at baseline. The proportion of patients with clinical improvement on day 28 was 61.3% in the CP+SOC group and 65.0% in the SOC group (difference −3.7%, 95% CI −18.8–11.3%). The results were similar in the severe and critically ill subgroups. There was no significant difference between CP+SOC and SOC groups in pre-specified secondary outcomes, including 28-day mortality, days alive and free of respiratory support and duration of invasive ventilatory support. Inflammatory and other laboratory marker values on days 3, 7 and 14 were similar between groups. Conclusions: CP+SOC did not result in a higher proportion of clinical improvement on day 28 in hospitalised patients with COVID-19 compared to SOC alone.
Published: 2022

11. Influence of temperature on the electrochemical coloration process and properties of the AISI 304 and 430 colored stainless steel

Author: Lacerda da Silva, Jaqueline, primary, Canella Carneiro, Andreia Rocha, additional, Castro, Geovane Martins, additional, Martins Nunes, Eduardo Henrique, additional, de Freitas Cunha Lins, Vanessa, additional, and Rabelo Junqueira, Rosa Maria, additional
Published: 2021
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12. Health status after invasive or conservative care in coronary and advanced kidney disease

Author: Spertus J. A., Jones P. G., Maron D. J., Mark D. B., O'Brien S. M., Fleg J. L., Reynolds H. R., Stone G. W., Sidhu M. S., Chaitman B. R., Chertow G. M., Hochman J. S., Bangalore S, ISCHEMIA-CKD Research Group: Abdallah M Abdallah, Abel E Moreyra, Abhay A Laddu, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Adedayo Adeboye, Agne Juceviciene, Agne Urboniene, Agnieszka Szramowska, Ahmed Abdel-Latif, Ahmed Ayoub, Ahmed Elghamaz, Ahmed Kamal, Ahmed Talaat, Ajay Sharma, Ajit Singh Narula, Akshay Bagai, Akvile Smigelskaite, Alain Raymond, Alain Rheault, Alaine Melanie Loehr, Albert Varga, Aldo P Maggioni, Alec Moorman, Alejandro Chevaile Ramos, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alexander M Chernyavskiy, Alexander Sergeevich Borisov, Alexandra Craft, Alexandra Hunter, Alexandre Ciappina Hueb, Alexandre Schaan de Quadros, Alice Manica Muller, Aline Peixoto Deiro, Allegra Stone, Almudena Castro, Amar Uxa, Amaryllis Van Craenenbroeck, Ambuj Roy, Amit Kakkar, Amy Flowers, Amy Iskandrian, Ana D Djordjevic-Dikic, Ana Gomes Almeida, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anandaroop Lahiri, Anastasia M Kuzmina-Krutetskaya, Anastasia Vamvakidou, Andras Vertes, Andre Gabriel, Andrea Bartykowszki, Andrea Lorimer, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew Starovoytov, Andrzej Łabyk, Anelise Kawakami, Angela Hoye, Angelo Nobre, Anjali Acharya, Anjali Anand, Anjana Rishmawi, Ann Banfield, Ann Luyten, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Teresinska, Anne Marie Webb, Anne Heath, Anoop Mathew, Antonia Vega, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anu Tharini, Anupama Rao, Aquiles Valdespino-Estrada, Ariel Diaz, Arif Asif, Arnold H Seto, Arturo S Campos-Santaolalla, Asim N Cheema, Asker Ahmed, Atul Mathur, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Balaji Srinivasan, Baljeet Kaur, Balram Bhargava, Bandula Guruge, Barbara Wicklund, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Benoy N Shah, Bernard de Bruyne, Beth Abramson, Beth Stefanchik, Bethany Harvey, Bharati Shivalkar, Bilal Malik, Binoy Mannekkattukudy Kurian, Bougrida Hammouche, Branko D Beleslin, Bruce Ferguson, Bruce McManus, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Carl-Éric Gagné, Carly Ohmart, Carol M Kartje, Caroline Alsweiler, Caroline Rodgers, Caroline Spindler, Carolyn J Gruber, Catherine Albert, Catherine Bone, Catherine Lemay, Cezary Kepka, Chandini Suvarna, Chantale Mercure, Charlene Wiyarand, Chetan Patel, Chiara Attanasio, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Buller, Christel Vassaliere, Christiaan Vrints, Christian Witzke, Christie Ballantyne, Christina Björklund, Christine Roraff, Christophe Laure, Christophe Thuaire, Christopher Chan, Christopher Fordyce, Christopher Kinsey, Chunli Xia, Cidney Schultz, Claes Held, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Clemens T Kadalie, Corine Thobois, Courtney Page, Cristina Bare, Dalisa Espinosa, Dan Gao, Dana Rizk, Daniela Puzhevsky, Data Analyst, David M Charytan, David O Williams, David Booth, David Charytan, David Cohen, David DeMets, David Foo, David Goldfarb, David Schlichting, David Sisson, David Taggart, David Waters, David Wheeler, David Williams, Davis Vo, Dawid Teodorczyk, Dawn D Shelstad, Dean Kereiakes, Deborah Yip, Deepa Ramaswamy, Deirdre Mattina, Deirdre Murphy, Dengke Jiang, Derek Cyr, Diana Cukali, Diane Camara, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Doreen Reimann, Doron Schwartz, Duarte Cacela, Dwayne S G Conway, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Eduardo Gomes Lima, Eduardo Hernandez-Rangel, Edward D Nicol, Edyta Kaczmarska, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise van Dongen, Elissa Restelli Piloto, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizaveta V Zbyshevskaya, Ellie Fridell, Ellis W Lader, Elvira Gosmanova, Emilie Tachot, Emma Howard, Emmanuel Sorbets, Encarnación Alonso-Álvarez, Eric Daugas, Erick Alexánderson Rosas, Estelle Montpetit, Eugene Passamani, Evgeny Shutov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, Fabio Fimiani, Fadi Hage, Fahim Haider Jafary, Fang Feng, Fatima Ranjbaran, Fausto J Pinto, Fernando Caeiro, Fernando Nolasco, Filipa Silva, Filippo Ottani, Firas Al Solaiman, Flávia Egydio, Florina Chereches, Francesca De Micco, Francesca Bianchini, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francisca Patuleia Figueiras, François Madore, Frank Harrell, Frank Rockhold, Frans Van de Werf, Franziska Guenther, Fred Mohr, G Karthikeyan, Gabriel Galeote, Gabriel Grossmann, Gabriel Steg, Gabriela Guzman, Gabriele Gabrielli, Gang Chen, Gautam Sharma, Gaylin Petty, Gelmina Mikolaitiene, Gennie Yee, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Girish Mishra, Gonzalo Barge-Caballero, Grace M Young, Graciela Scaro, Graham Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, Jan Henzel, Janaina Oliveira, Janani Rangaswami, Jane Eckstein, Janitha Raj, Jaqueline Pozzibon, Jaroslaw Drozdz, Jason Loh Kwok Kong, Jason T Call, Jason Linefsky, Javier J Garcia, Jay Meisner, Jayne Scales, Jean Michel Juliard, Jean Diodati, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeff Leimberger, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Stojkovic, Jenne M Jose, Jennifer L Stanford, Jennifer Hogan, Jennifer Horst, Jennifer Isaacs, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jerry Yee, Jessica Berg, Jesus Peteiro, Jesús Peteiro, Jia Li, Jiamin Liu, Jianxin Zhang, Jill Marcus, Jim Blankenship, Jing Dong, Jiyan Chen, Jo Evans, Joaquín V Peñafiel, Joe Sabik, Johann Christopher, John B Kostis, John Joseph Graham, John Doan, John Jose, John Kotter, John Lehman, John Middleton, John Pownall, Jonathan M Gleadle, Jonathan S Chavez-Iñiguez, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdy Abdelhamid, Magid Fahim, Mahevamma Mylarappa, Majo X Joseph, Malgorzata Frach, Manjula Rani, Marcello Galvani, Marcin Demkow, Marcin Szkopiak, Marco De Fabritis, Marco Magnoni, Marco Marini, Marco Sicuro, Marek Roik, Maria A Alfonso, Maria Antonieta Pereira de Moraes, María Dolores Martínez-Ruíz, Maria Eugenia Canziani, Maria Eugenia Martin, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Andreasson, Maria Posada, Marianna D A Dracoulakis, Mariano Rubio, Marija T Petrovic, Marina Vieira, Mario J Garcia, Mario D'arezzo, Maris Orgera, Marius Miglinas, Mark Garand, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Swiderek, Martha Meyer, Martina Ceseri, Martinia Tricoli, Mary Wiilliams, Mary Ann Champagne, Mary Streif, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Shinseki, Matthew Weir, Maura Carina Nédio, Max-Paul Winter, Mayil S Krishnam, Meenakshi Mishra, Mei Hwang, Melemadathil Srilatha, Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdończyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula García-González, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe Généreux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jesús-Pérez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto René Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, 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Wong, Gregg Pressman, Gregor Simonis, Gudrun Steinmaurer, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillermo Garcia-Garcia, Guoqin Wang, Gurpreet S Wander, Gurpreet Gulati, Haibo Zhang, Halina Marciniak, Hao Dai, Haojian Dong, Harold Franch, Harvey White, Hatem Elabd, Hayley Pomeroy, Heather Golden, Heidi Wilson, Helene Abergel, Hemalata Siddaram, Hemant Shakhar Mahapatra, Henry C Stokes, Hermine Osseni, Herwig Schuchlenz, Hicham Skali, Holly Mattix-Kramer, Hong Cheng, Hossam Mahrous, Hristo Pejkov, Hugo Marques, Hui Zhong, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ikraam Hassan, Ileana L Pina, Ilona Tamasauskiene, Inês Zimbarra Cabrita, Ines Rodrigues, Inga Soveri, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Isabelle Roy, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, Jacek Kusmierek, Jackie Chow, Jaekyeong Heo, Jakub Maksym, James E Davies, James J Jang, James Hirsch, James Tatoulis, 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Jonathan Lebowitz, Jonean Thorsen, Jorge Carrillo Calvillo, Jorge Escobedo, José A Ortega-Ramírez, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Costa Vieira, José M Flores-Palacios, Jose Fragata, Jose Lopes, Jose Lopez-Sendon, José Lopez-Sendon, Jose Rueda, Joseph B Selvanayagam, Joseph Sacco, Joshua P Loh, Joy Burkhardt, Juan Manuel López Quijano, Juan Gaztanaga, Judit Sebo, Judith Wright, Juergen Stumpf, Julia de Aveiro Morata, Julio César Figal, Julio Hernandez Jaras, Junqing Yang, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Karen Calfas, Karen Petrosyan, Karen Servilla, Karen Swan, Karin Ploetze, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Katharina Knaut, Katherine Martin, Kathleen Claes, Kathryn Mason, Ken Mahaffey, Kenneth Gin, Kerry Lee, Kerstin Bonin, Kerstin Mikes, Kevin R Bainey, Kevin T Harley, Kevin Marzo, Kevin McMahon, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khrystyna Kushniriuk, Kian-Keong Poh, Kim Holland, Kimberly E Halverson, Kinnari Murphy, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kreton Mavromatis, Krishnakumar Hongalgi, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristine Arges, Kristine Teoh, Krzysztof Drzymalski, Lalathaksha Kumbar, Laszlone Matics, LaTonya J Hickson, Laura Keinaite, Laura Sarti, Laura True, Lawrence M Phillips, Lawrence Friedman, Leandro C Maranan, Leda Lotaif, Lekshmi Dharmarajan, Leo A Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Li Hai Yan, Li Li, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilian Mazza Barbosa, Liljana Tozija, Linda Arcand, Lino Patricio, Liping Zhang, Lisa Hatch, Lixin Jiang, Liz Low, Loay Salman, Lorena Lopez, Lori Pritchard, Luis Bernanrdes, Luis Guzman, Lynette L Teo, M Sowjanya Reddy, Maarten Simoons, Maayan Konigstein, Mafalda Selas, Magdalena Madero, Magdalena Miller, 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Melissa LeFevre, Mengistu Simegn, Michael A Gibson, Michael B Rubens, Michael D Shapiro, Michael Chobanian, Michael Davidson, Michael Farkouh, Michael Mack, Michal Wlodarczyk, Michel G Khouri, Michelle Crowder, Michelle Ratliff, Miguel Borges Santos, Miguel Nobre Menezes, Miguel Perez Fontan, Miguel Barrero, Mihaly Tapolyai, Mikhail T Torosoff, Milan R Dobric, Milind Avdhoot Gadkari, Min Tun Kyaw, Miri Revivo, Mitchel B Lustre, Mohamed Adel, Mohamed Hassan, Mohammad El-Hajjar, Mohammed Hussain, Mohammed Saleem, Moisés Blanco-Calvo, Moisés Jiménez-Santos, Monika Laukyte, Muhamed Saric, Myrthes Emy Takiuti, Nadia Asif, Nagaraja Moorthy, Naima L Ogletree, Nana O Katamadze, Nandita Nataraj, Naomi Uchida, Nasrul Ismail, Natalia S Oliveira, Natalia de Carvalho Maffei, Nathalie Brosens, Naved Aslam, Naveed Akhtar, Neamat Mowafy, Neeraj Pandit, Neeraj Parakh, Neesh Pannu, Neill Duncan, Nevena Garcevic, Ngaire Meadows, Nicholas Danchin, Nicole Deming, Nikola N Boskovic, Nikolaos Karogiannis, Ning Zhang, Nirmal Kumar, Niruta Sharma, Nitika Chadha, Nitish Naik, Noelle M Durfee, Nora M Cosgrove, Norbert Urbanski, Norma Hogg, Olga Walesiak, Olga Zdończyk, Olga Zhdanova, Olivia Anaya, Olugbenga Bello, Omar Almousalli, Omar Thompson, Orit Kliuk, Oscar Méndiz, Óscar Prada-Delgado, Oz Shapira, Pablo Raffaele, Page Salanger, Pal Maurovich-Horvat, Pallav Garg, Paloma Moraga, Pam Singh, Pamela Ouyang, Pamela Woodard, Paola Emanuela Poggio Smanio, Paola Smanio, Paolo Calabro, Patricia K Nguyen, Patricia Alarie, Patricia Carrilho, Patricia Endsley, Patricia Pellikka, Patrycja Lebioda, Paul Der Mesropian, Paul Hauptman, Paula García-González, Paula Wilson, Paulo Cury Rezende, Paulo Novis Rocha, Pedro Canas Silva, Pedro Farto E Abreu, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peiyu He, Peter A McCullough, Peter H Stone, Peter Douglass, Peter Sizeland, Peter Voros, Philippe Gabriel Steg, Philippe Genereux, Philippe Généreux, Philippe Menasche, Philippe Rheault, Piero Tassinario, Pierre Gervais, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Poay-Huan Loh, Pouneh Samadi, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puneet Sodhi, Pushpa Naik, Qi Zhong, Qian Zhao, Qianqian Yuan, Qiulan Xie, Rachel Murphy, Radmila Lyubarova, Radmilar Lyubarova, Raewyn Fisher, Rafael Diaz, Rafael Maldonado, Rafael Selgas, Raffaele Bugiardini, Rafia Chaudhry, Raisa Kavalakkat, Rajalekshmi Vs, Rajesh Gopalan Nair, Rajiv Narang, Rakesh Yadav, Ramiro Carvalho, Ramon de Jesús-Pérez, Ran Leng, Ranjan Kachru, Raquel Sanchez, Raven R Dwyer, Raven Lee, Ray Wyman, Raymond C Wong, Reinette Hampson, Renato Abdala Karam Kalil, Renato D Lopes, Renato George Eick, Renato Lopes, Reshma Ravindran, Reto Andreas Gamma, Ricardo Costa, Richa Bhatt, Richard H J Trimlett, Risha Patel, Rita Coram, Robert K Riezebos, Robert M Donnino, Robert Guyton, Robert Harrington, Robert Malecki, Roberto René Favaloro, Robyn Elliott, Rodolfo G S D Lima, Rohit Tandon, Rolf Doerr, Roma Tewari, Ron Wald, Rongrong Hu, Rory Collins, Roxana Mehran, Roxy Senior, Rubén Baleón-Espinosa, Ruben Ramos, Rui Ferreira, Ruth Kirby, Ruth Pérez-Fernández, S Ramakrishnan, S K Dwivedi, Sadath Lubna, Sadiq Ahmed, Sajeev Chakanalil Govindan, Salamah Alfalahi, Salvador Cruz-Flores, Salvatore P Costa, Sampoornima Setty, Samuel Nwosu, Sandeep Mahajan, Sandeep Seth, Sandeep Singh, Sander R Niehe, Sandy Carr, Sanja Simic Ogrizovic, Sanja Ogrizovic, Sanjeev Gulati, Sanjeev Sharma, Sara Fernandez, Sarah Williams, Sarju Ralhan, Sasko Kedev, Satinder Singh, Satish Sankaranarayanan, Satvic Cholenahally Manjunath, Sau Lee, Schawana Thaxton, Sean M O'Brien, Sebastian Sobczak, Seema Nour, Sergey A Sayganov, Sérgio Bravo Baptista, Sergio Draibe, Seth Sokol, Sharad Chandra, Shari Mackedanz, Shaun Goodman, Shayan Shirazian, Sheetal Rupesh Karwa, Sheri Ussery, Sheromani Bajaj, Shirin Heydari, Shiv Kumar Choudhary, Shivali Patel, Shruti Pandey, Shuyang Zhang, Siddharth Gadage, Sik-Yin V Tan, Sílvia Zottis Poletti, Silvia Valbuena, Simone Savaris, Solomon Yakubov, Songlin Zhu, Sonika Gupta, Sorin Brener, Sothinathan Gurunathan, Soundarya Nayak, Sowjanya Reddy, Stanley E Cobos, Stefan Weikl, Stephanie M Lane, Stephanie Ferket, Stephanie Mavromichalis, Stephen Fremes, Steven A Fein, Steven P Sedlis, Steven Giovannone, Steven Weitz, Subhash Banerjee, Sudhanva S Hegde, Suellen Hosino, Sulagna Mookherjee, Suman Singh, Sumith Abeygunasekara, Sundeep Mishra, Sunil Kumar Verma, Suresh Kumar, Suryaprakash Narayanappa, Susan K Milbrandt, Susana Silva, Susanna Stevens, Suvarna Kolhe, Suzana Tavares, Suzanne Welsh, T A Kishore, Tamara Colaiácovo Soares, Tapan Umesh Pillay, Tarek Rashid, Tarun K Mittal, Tauane Bello Duarte, Téodora Dutoiu, Teresa Delgadillo, Terrance Chua, Terrance Welch, Theodoros Kofidis, Thierry Lefevre, Tiago Silva, Timea Boros, Titus Lau, Tiziana Formisano, Tomasz Ciurus, Tomasz Tarchalski, Tracy Tan, Umesh Lingaraj, V K Bahl, V S Narain, Valentina Pellu, Valentine Lobo, Valerie Robesyn, Vandana Yadav, Veerabhadra Gupta, Verghese Mathew, Vicente Miro, Victoria Gumerova, Victoria Hernandez, Vijay Kher, Vijay Kumar, Vikas Makkar, Vikranth Reddy, Viktoria Bulkley, Vinoi George David, Virendra Misra, Virginia Fernández-Figares, Vladimir Ryasniansky, Vojislav L Giga, Wael A Almahmeed, Wan Xian Chan, Wanda C Marfori, Wanda Parker, Wayne Pennachi, Wei Ling Lau, Weibing Xing, Weijing Bian, Wendy L Stewart, Wendy Drewes, Whady Hueb, William Weintraub, Winnie C Sia, Xacobe Flores-Ríos, Xiang Ma, Xiangqiong Gu, Xiaomei Li, Xiaoyi Xu, Xin Fu, Xuemei Li, Xutong Wang, Yanek Pépin-Dubois, Yaron Arbel, Yechen Han, Yiming Lit, Ying Tung Sia, Ying Wang, Yining Yang, Yitong Ma, Yolayfi Peralta, Yves Smets, Yvonne Taul, Zalina Kudzoeva, Zeljko Z Markovic, Zhangsuo Liu, Zhenyu Liu, Zhiming Ye, Zixiang Yu, Zoltan Davidovits, Zvezdana Petronijevic
Subjects: Male, Intention to Treat Analysi, medicine.medical_treatment, Health Status, Myocardial Ischemia, 030204 cardiovascular system & hematology, Coronary Angiography, law.invention, Health Statu, 0302 clinical medicine, Randomized controlled trial, law, Surveys and Questionnaires, Odds Ratio, Surveys and Questionnaire, 030212 general & internal medicine, Myocardial infarction, Coronary Artery Bypass, medicine.diagnostic_test, General Medicine, Middle Aged, Intention to Treat Analysis, Cardiology, Female, Human, medicine.medical_specialty, Revascularization, Follow-Up Studie, 03 medical and health sciences, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, cardiovascular diseases, Healthy Lifestyle, Renal Insufficiency, Chronic, Proportional Hazards Models, Aged, Intention-to-treat analysis, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Odds ratio, medicine.disease, Angiography, Exercise Test, Proportional Hazards Model, business, Kidney disease, Follow-Up Studies
Abstract: BACKGROUND In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, and advanced chronic kidney disease (an estimated glomerular filtration rate of
Published: 2020

13. THE OFFSPRING OF MOTHERS HARBORING APP/PS1 MUTATIONS PRESENTS EARLY CHANGES IN BRAIN METABOLISM AND MEMORY

Author: Pamela Ferreira, Andreia Rocha, Vanessa Ramos, Bruna Bellaver, Carolina Soares, Samuel Greggio, Gianina Venturin, Jaderson Costa da Costa, Marcelo Zimmer, and Eduardo Zimmer
Abstract: Background: Previous studies suggested that individuals with a maternal history of Alzheimer’s Disease(AD) are at higher risk of developing AD than individuals with a paternal history of AD. One could suggest that intra-uterine interactions might be responsible for elevating this risk. In this context, AD rodent models are highly suited for improving our understanding of this matter since animals reach adulthood in a few months. Objective: Here, we aimed at investigating changes in memory-related processes and brain metabolism on the offspring born to transgenic mothers harboring human APP/PS1 mutations. Methods: Rats born to F344-AD(Tg-AD) and WT mothers were evaluated in two different time-points: ~5.5, and ~9.5 months. Y-maze test was used to evaluate spatial working memory and micro-PET [18F]FDG was used to assess brain glucose metabolism. Results: Y-maze test demonstrated that rats born to transgenic mothers presented memory disturbances, indexed by spontaneous alternation, at ~5.5 months and ~9.5 months (figure 1A), while rats born to WT mothers and Tg-AD fathers exhibited a decline in spontaneous alternation only at ~9.5 months. rats born to AD-Tg mothers present brain glucose hypermetabolism at ~9,5 months. Conclusion: Our findings demonstrate that rats born to AD-Tg mothers harboring APP/PS1 mutations present cognitive decline and brain glucose metabolism abnormalities earlier than those born to WT mothers. Further studies are needed to understand the biological basis behind this phenomenon.
Published: 2021
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14. TEMPORAL CHANGES IN ASTROCYTES ON A TRANSGENIC RAT MODEL OF AD

Author: Andreia Rocha, Bruna Bellaver, Luiza Machado, Carolina Soares, Pâmela C. L. Ferreira, Samuel Greggio Gianina T. Venturin, Jaderson C. da Costa, Diogo O. Souza, and Eduardo R. Zimmer
Abstract: Background: Recent evidences have pointed to astrocytes as important players in the Alzheimer’s Disease (AD) pathogenesis. Objective: With this in mind, we aim to longitudinally investigate astrocyte changes in a new important AD transgenic model, the TgF344-AD rat, the first animal model harboring human APP/PS1 mutations which presents age-dependent amyloid and tau pathology. Methods: TgF344-AD rats and wild type littermates were evaluated in three time points: 3, 6 and 9 months of age. Rats underwent a [18F]FDG-microPET, a spatial-memory, an astrocytes CSF biomarkers (ELISA multiplex) and a glutamate uptake (ex-vivo slices) analysis. Examination of further time-points are being conducted at the moment. Results: At 9 months of age, TgF344-AD animals presented an increase in the cortical [18F]FDG uptake and a decline in their alternance performance in the Y-maze task. In the CSF analysis, GFAP was elevated at both 6 months and 9 months, while S100B presented a decrease at 6mo. Additionally, the cortical glutamate uptake was increased at 9 months. Conclusion: This study is the first to longitudinally investigate the in vivo brain glucose metabolism in the TgF344-AD rat model. Our results suggest that this model presents an early increase on glucose metabolism which may be related to astrocytes activation and the increase of glutamate uptake by these cells. Furthermore, we also identified a spatial memory impairment at the same age.
Published: 2021
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15. Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension. final safety data from the EXPERT registry

Author: Hossein-Ardeschir Ghofrani, Miguel-Angel Gomez Sanchez, Marc Humbert, David Pittrow, Gérald Simonneau, Henning Gall, Ekkehard Grünig, Hans Klose, Michael Halank, David Langleben, Repke J. Snijder, Pilar Escribano Subias, Lisa M. Mielniczuk, Tobias J. Lange, Jean-Luc Vachiéry, Hubert Wirtz, Douglas S. Helmersen, Iraklis Tsangaris, Joan A. Barberá, Joanna Pepke-Zaba, Anco Boonstra, Stephan Rosenkranz, Silvia Ulrich, Regina Steringer-Mascherbauer, Marion Delcroix, Pavel Jansa, Iveta Šimková, George Giannakoulas, Jens Klotsche, Evgenia Williams, Christian Meier, Marius M. Hoeper, Jorge Caneva, Graciela Tuhay, Mirta Diez, Maria Lujan Talavera, Adriana Acosta, Norberto Vulcano, Martin Bosio, Lorena Maldonado, Sabino Deleo, Luciano Melatini, Anne Keogh, Eugene Kotlyar, John Feenstra, Nathan Dwyer, Heath Adams, Wendy Stevens, Peter Steele, Susanna Proudman, Robert Minson, Glenn Reeves, Melanie Lavender, Benjamin Ng, Michele Mackenzie, Lisa Barry, Margarethe Gruenberger, Charlotte Huber, Irene Lang, Ioana Tilea, Roela Sadushi-Kolici, Judith Löffler-Ragg, Lisa-Theresa Feistmantl, Patrick Evrard, Renaud Louis, Julien Guiot, Marco Naldi, Michel De Pauw, Sanjay Mehta, Rafael Conde Camacho, Patricia Parada Tovar, Alejandro Londoño, Felipe Campo, Paula Garcia, Camila Lema, Mauricio Orozco-Levi, William Martinez, Juan Esteban Gomez, Jens Erik Nielsen-Kudsk, Soren Mellemkjaer, Ly Anton, Alan Altraja, Tapani Vihinen, Tuija Vasankari, Olivier Sitbon, Vincent Cottin, Laurent Têtu, Elise Noël-Savina, Nicole Shearman, Susanne Tayler, Ilona Olzik, Christine Kulka, Jan Grimminger, Marcel Simon, Anna Nolde, Tim Oqueka, Lars Harbaum, Benjamin Egenlauf, Ralf Ewert, Christian Schulz, Sabine Regotta, Tilmann Kramer, Susanne Knoop-Busch, Felix Gerhardt, Stavros Konstantinides, Georgia Pitsiou, Ioannis Stanopoulos, Evdokia Sourla, Sofia Mouratoglou, Haralambos Karvounis, Athanasios Pappas, Dimitrios Georgopoulos, Michail Fanaridis, Ioanna Mitrouska, Lampros Michalis, Konstantinos Pappas, Anna Kotsia, Sean Gaine, Carmine Dario Vizza, Giovanna Manzi, Roberto Poscia, Roberto Badagliacca, Piergiuseppe Agostoni, Noemi Bruno, Stefania Farina, Michele D'Alto, Paola Argiento, Anna Correra, Giovanni Maria Di Marco, Chiara Cresci, Vieri Vannucchi, Elena Torricelli, Alessio Garcea, Alberto Pesci, Luca Sardella, Giuseppe Paciocco, Federico Pane, Andrea Maria D'Armini, Maurizio Pin, Valentina Grazioli, Giulia Massola, Antonio Sciortino, Renato Prediletto, Carolina Bauleo, Edoardo Airò, Rudina Ndreu, Ivana Pavlickova, Claudio Lunardi, Massimiliano Mulè, Silvia Farruggio, Serena Costa, Giuseppe Galgano, Mario Petruzzi, Anna De Luca, Francesco Lombardi, Loris Roncon, Luca Conte, Claudio Picariello, Gil Wirtz, Myriam Alexandre, A. Vonk-Noordegraaf, H. Boogaard, J. Mager, H. Reesink, Leon M. van den Toorn, Karin Boomars, Arne K. Andreassen, Graça Castro, Gonçalves Tania, Rui Baptista, António Marinho, Teresa Shiang, Ana Oliveira, Daniel Coutinho, Joana Sousa, Maria José Loureiro, Débora Repolho, Susana Maria Martins Jesus, Marta Capinha, João Agostinho, Tania Cardoso, Andreia Rocha, Mafalda Espinha, Kyundyul Ivanovich Ivanov, Dalyana Eduardovna Alexeeva, Marina Vadimovna Batalina, Daria Viktorovna Hegya, Tatyana Nikolaevna Zvereva, Sergey Nikolaevich Avdeev, Natalia Anatolievna Tsareva, Albert Sarvatovich Galyavich, Bykov Aleksander Nikolaevich, Evgeny Vladimirovich Filippov, Olga Eduardovna Yakovleva, Olga Borisovna Pavlova, Elena Sergeevna Skripkina, Tamila Vitalievna Martynyuk, Irina Fedorovna Bukatova, Anna Viktorovna Tregubova, Dmitry Yurievich Platonov, Tatyana Mikhaylovna Kolomeytseva, Abdullah Al Dalaan, Abeer Abeer Abdelsayed, Ihab Weheba, Sarferaz Saleemi, Hussam Sakkijha, Marcela Bohacekova, Tatiana Valkovicova, Iveta Farkasova, Carlos Andres Quezada, Lucilla Piccari, Isabel Blanco, Laura Sebastian, Antonio Roman, Manuel Lopez, Remedios Otero, Teresa Elias, Luis Jara, Isabel Asencio, Josefa Jiménez Arjona, Raúl Menor Almagro, Salvador López Cárdenas, Salvador Alcaraz García, Patricia Villanueva Rodríguez, Raquel Lopez, Alberto Garcia, Francisco Fernandez Avilés, Sebastian De La Pava, Raquel Yotti, Gregorio Pérez Peñate, Fernando León Marrero, José Manuel Cifrián Martínez, Amaya Martinez-Meñaca, Lecue Pilar Alonso, Sonia Fernandez Rozas, David Iturbe Fernandez, Victor Mora Cuesta, Stefan Söderberg, Sven-Erik Bartfay, Bengt Rundqvist, Monthir Alfetlawi, Peter Wodlin, Esther Irene Schwarz, Rudolf Speich, Frédéric Lador, Thierry Rochat, Paola Gasche-Soccal, Chih-Hsin Hsu, Tsung-Hsien Lin, Ho-Ming Su, Wen-Ter Lai, Chun Yuan Chu, Po-Chao Hsu, Wen-Chol Voon, Hsueh-Wei Yen, Jacob Yih-Jer Wu, Shu-Hao Wu, Wen-Pin Huang, Man-Cai Fong, Chien-Lung Huang, Ping-Hung Kuo, Yen-Hung Lin, Jiunn-Lee Lin, Chi-Sheng Hung, Cho-Kai Wu, Shih-Hsien Sung, Wei-Chun Huang, Chin-Chang Cheng, Shu-Hung Kuo, Wen-Hwa Wang, Wan-Jing Ho, Tsu-Shiu Hsu, Bülent Mutlu, Halil Atas, Gul Ongen, Zeynep Un, Gulfer Okumus, Ismail Hanta, Paul Corris, Andrew Peacock, Colin Church, Mark Toshner, Michael Newnham, Gastroenterology & Hepatology, Pulmonary Medicine, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, and VU University medical center
Subjects: real-world, pulmonary embolism, pyrimidines, MedDRA, data analysis, Peripheral edema, Chronic thromboembolic pulmonary hypertension, randomized controlled trials as topic, Clinical practice, registry, time factors, law.invention, chronic thromboembolic pulmonary hypertension, 0302 clinical medicine, Randomized controlled trial, law, middle aged, Medicine, 030212 general & internal medicine, humans, Hipertensió pulmonar, pyrazoles, clinical practice, aged, female, riociguat, safety, chronic disease, hypertension, pulmonary, male, multicenter studies as topic, prospective studies, recurrence, treatment outcome, registries, medicine.symptom, Safety, medicine.drug, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Registry, hypertension, pulmonary, Hypertension, Pulmonary, Riociguat, Pulmonary hypertension, 03 medical and health sciences, Internal medicine, Adverse effect, business.industry, medicine.disease, Pneumonia, 030228 respiratory system, Real-world, Pulmonary hemorrhage, business
Abstract: Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase 3 randomized trials. The EXPosurE Registry RiociguaT in patients with pulmonary hypertension (EXPERT) study was designed to monitor the long-term safety of riociguat in clinical practice. Methods: EXPERT was an international, multicenter, prospective, uncontrolled, non-interventional cohort study of patients treated with riociguat. Patients were followed for at least 1 year and up to 4 years from enrollment or until 30 days after stopping riociguat treatment. Primary safety outcomes were adverse events (AEs) and serious adverse events (SAEs) coded using Medical Dictionary for Regulatory Activities preferred terms and System Organ Classes version 21.0, collected during routine clinic visits and collated via case report forms. Results: In total, 956 patients with CTEPH were included in the analysis. The most common AEs in these patients were peripheral edema/edema (11.7%), dizziness (7.5%), right ventricular (RV)/cardiac failure (7.7%), and pneumonia (5.0%). The most common SAEs were RV/cardiac failure (7.4%), pneumonia (4.1%), dyspnea (3.6%), and syncope (2.5%). Exposure-adjusted rates of hemoptysis/pulmonary hemorrhage and hypotension were low and comparable to those in the long-term extension study of riociguat (Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase–Stimulator Trial [CHEST-2]). Conclusion: Data from EXPERT show that in patients with CTEPH, the safety of riociguat in routine practice was consistent with the known safety profile of the drug, and no new safety concerns were identified. © 2020 The Authors Eli Lilly and Company; Pfizer; Bayer; GlaxoSmithKline; Merck; Actelion Pharmaceuticals; Meso Scale Diagnostics; United Therapeutics Corporation; Novartis Pharma; Merck Sharp and Dohme; GlaxoSmithKline Australia; Deutsche Forschungsgemeinschaft; Grupo Ferrer Internacional, S.A The EXPERT registry was funded by Bayer AG (Berlin, Germany) and Merck Sharp & Dohme Corp., a subsidiary of Merck & Co. Inc., Kenilworth, NJ, USA. The authors acknowledge the database administration by Torsten Tille, Dresden, and the project administration of Mrs Romy Hoppenz and Mrs Linda Kottke at GWT-TUD GmbH, Dresden. Medical writing services provided by Richard Murphy PhD of Adelphi Communications Ltd, Macclesfield, UK were funded by Bayer AG in accordance with Good Publication Practice (GPP3) guidelines. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Prof Marius M. Hoeper reports personal fees from Bayer AG, during the conduct of the study; personal fees from Actelion, personal fees from Acceleron, personal fees from MSD, personal fees from Jansen, personal fees from Pfizer, outside the submitted work. Dr Hans Klose reports speaker and consultancy fees from Actelion, Bayer AG, GSK, Novartis, Pfizer, and United Therapeutics and research support from Actelion, Bayer AG, GSK, Pfizer, and MSD. Dr Michael Halank reports personal fees and non-financial support from Actelion, AstraZeneca, Bayer AG, Berlin-Chemie, GSK, OMT, MSD, and Novartis. Dr George Giannakoulas reports speaker and consultancy fees from Actelion, Bayer, ELPEN Pharmaceuticals, GSK, Pfizer, Lilly, and United Therapeutics, and research support from GSK, ELPEN Pharmaceuticals, and Galenica. Dr Henning Gall has received honoraria and/or other support from Actelion, AstraZeneca, Bayer, BMS, GSK, Janssen-Cilag, Lilly, MSD, Novartis, OMT, Pfizer, and United Therapeutics. Dr Pavel Jansa reports consultancy and speaker fees from MSD, AOP Orphan, and Actelion. Prof Ekkehard Grünig reports research grants and speaker honoraria/consultancy fees from Actelion and Bayer/MSD, research grants from GSK, United Therapeutics, Bellerophon, OMT GmbH, Pfizer, Reata, and Novartis, and speaker honoraria from Bial, Medscape, and OrPha Swiss GmbH. Prof David Pittrow reports personal fees from Actelion, Bayer AG, Aspen, Boehringer Ingelheim, Sanofi, Biogen, Shire, and MSD outside the submitted work. Silvia Ulrich reports research grants and personal fees from Actelion, Bayer, MSD, and Orpha Swiss. Tobias J. Lange has received personal fees from Actelion, MSD, Pfizer, and OMT orphan. Dr Iraklis Tsangaris reports speaker and consultancy fees from Actelion, Bayer AG, ELPEN, GSK, MSD, Pfizer, and United Therapeutics. Stephan Rosenkranz reports remunerations for lectures and/or consultancy from Abbott, Actelion, Arena, Bayer, Ferrer, GSK, MSD, Novartis, Pfizer, and United Therapeutics; and research support to his institution from Actelion, Bayer, Novartis, Pfizer, and United Therapeutics. Repke J. Snijder reports grants from Pfizer and Actelion Pharmaceuticals. Prof Iveta Šimková reports consultancy and speaker fees from MSD, AOP Orphan, and Actelion. Dr Marc Humbert reports grants and personal fees from Bayer and GSK, and personal fees from Actelion, Merck, and United Therapeutics. Marion Delcroix has received investigator, speaker, consultant, and steering committee member fees from Actelion, Bayer AG, Bellerophon, Eli Lilly, GlaxoSmithKline, MSD, Pfizer, and Reata, and research grants from Actelion. Joan A. Barberà reports receipt of honoraria for consultation or speaker fees from Actelion and Merck; and research support through his institution from Actelion, Merck, GlaxoSmithKline, and Ferrer. Joanna Pepke-Zaba reports research grants and speaker honoraria/consultancy fees from Actelion, Bayer/MSD, and GSK. Jean-Luc Vachiéry reports ongoing consultancies to Actelion, Sonnivie, Arena Pharma, Bial Portela, and Respira Therapeutics, past consultancies to AstraZeneca, BayerShering, CardioMEMS, GlaxoSmithKline, Pfizer, Merck, and United Therapeutics, and current membership of an advisory board or similar group for Actelion and GlaxoSmithKline. Jean-Luc Vachiéry's institution receives funding from Actelion Pharmaceuticals for performing clinical studies. Regina Steringer-Mascherbauer, Jens Klotsche, and Miguel-Angel Gomez Sanchez have no conflicts of interest relevant to the EXPERT study. Hossein-Ardeschir Ghofrani reports personal fees for advisory board work, and payment for lectures including service on speaker bureaus, from Actelion, Bayer, GSK, Novartis, and Pfizer; consultancy fees from Actelion, Bayer, Bellerophon Pulse Technologies, GSK, MSD, Novartis, and Pfizer; and grants from Deutsche Forschungsgemeinschaft (DFG). Pilar Escribano Subias reports personal fees from Actelion, Bayer AG, GlaxoSmithKline, and Merck Sharp & Dohme, and grants from Actelion, Bayer AG, GlaxoSmithKline, and Ferrer, outside the submitted work. Gérald Simonneau reports personal fees and non-financial support from Actelion, personal fees and non-financial support from Bayer, personal fees and non-financial support from MSD, outside the submitted work. Douglas S. Helmersen reports industry-sponsored research with Bayer AG, United Therapeutics, and Gilead Sciences, Inc., and advisory board/speaker fees from Bayer AG and Actelion. David Langleben reports honoraria, consultation fees, research support, and/or travel expenses from Actelion, Arena, Bayer AG, Northern Therapeutics, PhaseBio, Acceleron, Janssen, and United Therapeutics. Anco Boonstra reports consultancy fees from Pfizer BV and hospitality from Teva Nederland. Lisa M. Mielniczuk reports speaker fees and honoraria from Bayer AG, and speaker fees, consultancy fees, and travel fees from Actelion. Evgenia Williams and Christian Meier are employees of Bayer AG.
Published: 2021
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16. Carotid revascularization: endarterectomy versus stenting. A systematic review and meta-analysis

Author: Andreia Rocha Ministro and Instituto de Ciências Biomédicas Abel Salazar
Subjects: Ciências da saúde [Ciências médicas e da saúde], Health sciences, Health sciences [Medical and Health sciences], Ciências da saúde
Published: 2020

17. Easy functionalization process applied to develop super-hydrophobic and oleophobic properties on ASTM 1200 aluminum surface

Author: Manuel Houmard, Fábio Augusto de Souza Ferreira, and Andreia Rocha Canella Carneiro
Subjects: Surface (mathematics), Materials science, chemistry.chemical_element, 02 engineering and technology, Surfaces and Interfaces, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Ormosil, Isotropic etching, 0104 chemical sciences, Surfaces, Coatings and Films, chemistry, Chemical engineering, Aluminium, Scientific method, Materials Chemistry, Surface modification, 0210 nano-technology
Published: 2018
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18. Influência de contaminantes ambientais na patogénese de doenças neurodegenerativas

Author: Oliveira, Cátia Andreia Rocha and Álvarez Pérez, Francisco José
Subjects: Ciências Médicas::Ciências da Saúde::Medicina [Domínio/Área Científica], Contaminantes Ambientais, Doença de Parkinson, Esclerose Lateral Amiotrófica, Neurodegeneração, Doença de Alzheimer
Abstract: Made available in DSpace on 2020-01-27T17:09:13Z (GMT). No. of bitstreams: 1 6864_14654.pdf: 564399 bytes, checksum: edf3495754771f61f3810ed3b5c58902 (MD5) Previous issue date: 2019-07-12
Published: 2019

19. Entrepreneurship Program at Secondary School

Author: Andreia Rocha and Maria José Madeira
Subjects: Entrepreneurship, business.industry, Sociology, Public relations, business
Abstract: The aim of this study is the analysis of the effect that the entrepreneurship activities have in the development of an entrepreneurial profile of the students of a secondary level and their future entrepreneurial intentions. To empirically test the formulated hypothesis, a questionnaire was developed. By the application of methods of factorial analysis and a logistic regression model, it was concluded that variables like the incentive given by school agents, the participation of students in extracurricular activities and the desire to continue studying, influenced the entrepreneurial intentions of the students. Concerning the entrepreneurial profile, it was concluded that the students who have higher capacity of creation and concretization of entrepreneurial projects and a winning will, have a higher propensity to create their own business. This research analysed the impact of entrepreneurship activities on the development of the secondary school students' entrepreneurial profile, and understand whether these same activities influence their future intentions.
Published: 2019
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20. Caracterização física e química de frutos de bacupari, Salacia Crassifolia (Mart. ex Schult.) G. Don, provenientes do município de Barreiras –BA

Author: Schneider, Lucinéia Cavalheiro, primary, Leão, Katyuscya Veloso, additional, Machado, Luciana Lucas, additional, and Guimarães, Andreia Rocha Dias, additional
Published: 2020
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21. Influence of temperature on the electrochemical coloration process and properties of the AISI 304 and 430 colored stainless steel

Author: Silva, J.L., Carneiro, Andreia Rocha Canella, Castro, Geovane Martins, Nunes, Eduardo Henrique Martins, Lins, Vanessa de Freitas Cunha, and Junqueira, Rosa Maria Rabelo
Abstract: The influence of temperature on the speed of an electrochemical coloration process of AISI 304 and AISI 430 stainless steel was investigated in temperature ranging from 25 °C to 40 °C. The surface properties of the interference colored nanofilms obtained in both types of stainless steel substrates, were also evaluated. A higher coloring speed was observed for AISI 304. The coloring time to obtain a gold color decreased with increasing temperature for both steels. This effect was stronger on the AISI 430 substrate, with a decrease of 36.6% in the coloration time for the samples colored at 40 °C and 25 °C. The Arrhenius model was applied to estimate the equations of colored films growth rate. The films porous fractions evaluated by SEM were in the range of 27–29%, without relevant variation with the coloring temperature. The nanohardness of the conjugated film-substrate obtained in a nanoindenter coupled to an AFM shows lower values than the uncolored substrates, and this reduction is more significant for the films grown on the AISI 430 ferritic specimens. The wettability of the surface to water and oil increased after coloring. The amplification effect of the hydrophilic effect can be associated with the increased AFM nanorugosity values.
Published: 2022
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22. Desenvolvimento de superfícies super-hidrofóbicas e oleofóbicas em liga de alumínio através da deposição de recobrimentos sol-gel

Author: Andreia Rocha Canella Carneiro, Manuel Noel Paul Georges Houmard, and Fábio Augusto de Souza Ferreira
Subjects: Alcoxisilanos, Alumínio, Aluminio, Super-hidrofobicidade, Oleofobicidade, ORMOSIL, Funcionalização de superfícies, Engenharia quimica
Abstract: Nos últimos anos, o desenvolvimento de superfícies super-hidrofóbicas vem recebendo atenção cada vez maior da academia à indústria pelas potenciais aplicações que podem agregar à superfície de metais, vidros, cerâmicos e polímeros. Nesse trabalho, o objetivo foi desenvolver revestimentos super-hidrofóbicos em substratos da liga de alumínio ASTM 1200 H14. As superfícies foram tratadas a fim de se produzir uma estrutura rugosa apropriada seguida da deposição de revestimentos obtidos a partir de precursores com caráter hidrofóbico. Os substratos tiveram a rugosidade de suas superfícies modificadas por ataque químico em solução ácida oxidante composta por FeCl3, HCl e H2O2, conhecida como FHH, e receberam recobrimentos de ORMOSIL produzidos com os precursores 1H,1H,2H,2H-perfluorooctiltrietoxisilano (PFOTES) e hexadeciltrimetoxisilano (HDTMS). Todos os substratos de alumínio, antes e após ataque químico, foram limpos por ultrassom, em sequência com acetona e água deionizada, durante 5 minutos, e secos em fluxo de ar quente. Os materiais tiveram seus ângulos de contato com água e óleo medidos utilizando um tensiômetro e suas características morfológicas e químicas avaliada por meio de microscopia confocal, Microscopia Eletrônica de Varredura (MEV) acoplada a Espectroscopia de Energia Dispersiva de Raios X (EDS), espectroscopia de fotoelétrons excitados por raios X (XPS) e espectroscopia da região do infravermelho com transformada de Fourier (FTIR). As superfícies resultantes se mostraram super-hidrofóbicas, com ângulo de contato médio com a água maior do que 150° e ângulo de deslizamento menor do que 5°. As superfícies rugosas recobertas com ORMOSIL de PFOTES apresentaram também propriedades oleofóbicas, com valores de ângulo médio de contato com óleo mineral em torno de 136°, sendo definidas como anfifóbicas. Foram realizadas também deposições utilizando diferentes composições de ORMOSIL obtidos pela mistura entre PFOTES e TEOS (tetraetilortosilicato) visando à redução dos custos, uma vez que o PFOTES é um composto relativamente caro, sem a perda das propriedades anfifóbicas. Os resultados revelaram que as misturas poderiam reduzir significativamente os custos do processo na preparação dessas superfícies. In recent years, the development of superhydrophobic surfaces has been receiving increasing attention from academia to industry for the potential applications that can add to the surface of metals, glass, ceramics and polymers. In this work, the objective was to develop superhydrophobic coatings on ASTM 1200 H14 aluminum alloy. The surfaces were treated in order to produce a suitable rough structure followed by the deposition of coatings obtained from hydrophobic precursors. The substrates had surface roughness modified by etching in an oxidizing acid solution composed of FeCl3, HCl and H2O2, known as FHH, and received ORMOSIL coatings produced with the precursors 1H,1H,2H,2H-perfluorooctyltriethoxysilane (PFOTES) and hexadecyltrimethoxysilane (HDTMS). All aluminum substrates, before and after chemical etching, were ultrasonically cleaned in sequence with acetone and deionized water for 5 min, and dried in a stream of hot air. The materials had their contact angles with water and oil measured using a tensiometer and their morphological and chemical characteristics evaluated through confocal microscopy, Scanning Electron Microscopy (SEM) coupled to X-ray Dispersive Energy Spectroscopy (EDS), X-ray excited photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy. The resulting surfaces were superhydrophobic, with mean contact angles with water greater than 150° and slip angle less than 5°. The rough surfaces covered with ORMOSIL of PFOTES also presented oleophobic properties, with mean contact values with mineral oil around 136°, being defined as amphiphobic. Deposits were also made using different ORMOSIL compositions obtained by mixing PFOTES and TEOS (tetraethyl orthosilicate) in order to reduce costs, since PFOTES is a relatively expensive compound without loss of amphiphic properties. The results revealed that the blends could significantly reduce process costs in the preparation of these surfaces.
Published: 2017

23. The impact of financial crisis on portuguese firms' capital structure

Author: Lemos, Jéssica Andreia Rocha and Laureano, Luís
Subjects: Portugal, Capital structure, Trade-off theory, Financial crisis, Ciências Sociais::Outras Ciências Sociais [Domínio/Área Científica], Estrutura de capital, G Financial economics, Fundo monetário internacional, International Monetary Fund, Crise financeira - 2011-2013, G32, G01, Empresa, Regressão linear
Abstract: This study aims to verify the impacts of financial crises in the capital structure for Portuguese companies. The purpose is to study different firm-specific determinants of a sample of general PSI Portuguese listed firms at the Euronext Lisbon stock exchange, during the recent crises that endured from 2011 until 2013 and test the impacts on short and long-term debt. In order to test the changes/impacts on Portuguese firms’ capital structure, the most important theories around capital structure decisions, Modigliani & Miller, Trade-off, Pecking Order and the Agency theory, will be presented. Among the many determinants that are considered to influence capital structure decisions, size, profitability, tangibility, growth, liquidity and non-debt tax shield, were chosen to test their impacts on Portuguese company. The sample used considers the period from 2005 to 2015 for 33 Portuguese listed firms. A regression analysis will be used to infer about the effects on long-term and short-term debt when the determinants change. Results obtained support both trade-off and pecking order theories. Short-term debt ratios reported a tendency of increase during the financial crisis while long-term debt registered a decrease. Este estudo visa verificar quais os impactos das crises financeiras na estrutura de capital das empresas portuguesas. Tem como objetivo estudar determinantes específicas da estrutura de capital das empresas portuguesas do PSI geral cotadas em bolsa, durante o período da recente crise financeira, que durou desde 2011 até 2013. Por forma a testar as mudanças/impactos na estrutura de capital das empresas portuguesas, algumas das principais teorias à volta do tema da decisão da estrutura de capital, tais como, "Modigliani & Miller", "Trade-off", "Pecking Order" e "Agency Theory", vão ser apresentadas. De entre as muitas variáveis que são consideradas como afetadoras da estrutura de capital de uma empresa, tamanho, lucrabilidade, tangibilidade dos ativos, crescimento, liquidez e o escudo fiscal da não dívida, foram selecionados para testar os seus impactos nas empresas portuguesas. A amostra de tempo considerada reuniu informação do período de 2005 até 2015 para 33 das empresas portuguesas cotadas em bolsa. Foi utilizada a regressão linear para testar os impactos que as alterações nas determinantes consideradas como variáveis dependentes têm nas dívidas de curto e longo prazos. Os resultados obtidos suportam tanto a teoria de "Trade-off" e "Pecking Order". Os rácios para a dívida de curto prazo aumentaram durante o período da crise financeira enquanto o rácio da dívida de longo prazo diminuiu.
Published: 2017

24. Os confessores de D. Pedro II (1668-1706) : os directores de consciência régia

Author: Camarão, Lígia Andreia Rocha and Reis, Maria de Fátima
Subjects: Portugal - Reis e soberanos - Aspectos religiosos - 1668-1706, Teses de mestrado - 2017, Igreja e Estado - Portugal - séc.17, Jesuítas - Portugal - séc.17, Confessores - Portugal - 1668-1706, Pedro II, Rei de Portugal, 1648-1706, Humanidades::História e Arqueologia [Domínio/Área Científica]
Abstract: Submitted by Manuel Moreno (manuelmoreno@campus.ul.pt) on 2017-08-22T15:05:04Z No. of bitstreams: 1 ulfl234008_tm.pdf: 1824080 bytes, checksum: f8659e3bda7e2ffe26d5425f4fa4c328 (MD5) Made available in DSpace on 2017-08-22T15:05:19Z (GMT). No. of bitstreams: 1 ulfl234008_tm.pdf: 1824080 bytes, checksum: f8659e3bda7e2ffe26d5425f4fa4c328 (MD5) Previous issue date: 2017-05-03
Published: 2017

25. Os efeitos da depressão na memória operatória: impacto da valência emocional

Author: Carla Andreia Rocha Melo Martins de Oliveira and Faculdade de Psicologia e de Ciências da Educação
Subjects: Psicologia, Psychology [Social sciences], Psicologia [Ciências sociais], Psychology
Published: 2013

26. Relações na infância com as figuras significativas e violência na intimidade: um estudo qualitativo com agressores

Author: Oliveira, Filipa Andreia Rocha, Gonçalves, Rui Abrunhosa, and Universidade do Minho
Subjects: Meaning, Childhood relationships, 343.95, Intimate violence, Significados, Agressores, Aggressors, Violência na intimidade, Relações na infância, Análise qualitativa, Qualitative analysis
Abstract: Dissertação de mestrado integrado em Psicologia (área de especialização em Psicologia da Justiça), O presente estudo, de cariz exploratório, teve como objetivo compreender o modo como os agressores significam as suas relações com as figuras significativas na infância e analisar de que forma essas relações são utilizadas para darem sentido a si próprios e à violência que exercem sobre a companheira. Para tal, entrevistaram-se 8 agressores que integravam o Programa de Promoção e Intervenção com Agressores Conjugais (PPRIAC), adaptando-se o guião da entrevista sobre a vinculação para adultos e adolescentes – versão portuguesa da Adult Attachment Interview – AAI de Soares (1992). Procedeu-se à análise dos relatos dos agressores, seguindo a metodologia da Análise Temática e recorrendo ao software Nvivo. Os resultados indicam que os agressores significam as relações na infância como tendo uma influência significativa no seu desenvolvimento identitário e nos comportamentos violentos que perpetram contra a companheira. Globalmente, as relações negativas na infância são utilizadas para justificar a adoção de comportamentos abusivos na adultez, referindo a sua influência no desenvolvimento de características pessoais e no défice de competências ou recursos. Conclui-se que este discurso desresponsabiliza o agressor e pode legitimar práticas abusivas, devendo ser um tópico a considerar na intervenção com agressores., The present study, exploratory approach, aimed at understanding how aggressors conceive their relationship with significant figures in their childhood and analyse how these relations are used to make sense of themselves and for explaining their violence towards the partner. Eight aggressors that participate in the Program for the Promotion and Intervention with Conjugal Offenders (PPRIAC) were interviewed, with an adapted version, of the interview on the attachment for adults and adolescents – Portuguese version of the Adult Attachment Interview – AAI Soares (1992). Reports were analysed following the methodology and thematic analysis of the software NVivo. The results indicate that the aggressors consider their relationships in childhood have a significant influence on their identity development and violent behavior against their partner. Overall, the negative relationships in childhood are used to justify the adoption of abusive behaviors in adulthood, referring to his influence on the development of personal characteristics and lack of skills or resources. We consider this speech is used to justify the offender and to legitimize abusive practices, therefore it is a topic that should be considered in intervention with aggressors.
Published: 2013

27. O LETRAMENTO CRÍTICO E A FORMAÇÃO DO PROFESSOR-CIDADÃO: caminhos possíveis para a transformação da prática e da posição docentes

Author: Andreia Rocha, Alessandra H. B. Fukumoto, and Leina Jucá
Subjects: General Agricultural and Biological Sciences
Abstract: A busca por possíveis caminhos que proporcionassem a transformação de práticas de ensino e aprendizagem de línguas motivou um grupo de professoras (inglês, italiano, libras, português como segunda língua) a se reunir para repensar suas práticas docentes e a formação de seus alunos. O Letramento Crítico foi a mola propulsora desse grupo que, desde o primeiro semestre de 2011, se encontra semanalmente para discutir, refletir e compartilhar meios que propiciem a formação de cidadãos críticos capazes de estabelecer relações entre língua, cidadania, cultura, práticas sociais e formação de professores. Neste relato, buscamos compartilhar os resultados das discussões advindas de nossos encontros, procurando mostrar como nos reposicionamos em relação à docência e como esse resposicionamento tende a interferir e modificar nossas práticas docentes.
Published: 2011
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28. Novos artigos e sistemas no processamento do couro

Author: Carvalho, Marta Andreia Rocha and Crispim, Alfredo
Subjects: Shrunken, Crispado, Leather, Dyeing, Solar energy, Energia solar, Couro, Wet-white, Tinturaria
Abstract: Submitted by Manuel Brandão (msa@eu.ipp.pt) on 2013-11-18T13:55:05Z No. of bitstreams: 1 DM_MartaCarvalho_2010_MEQ.pdf: 3051803 bytes, checksum: 7956a4f144fa95317239da7e0a92da3f (MD5) Made available in DSpace on 2013-11-18T13:55:05Z (GMT). No. of bitstreams: 1 DM_MartaCarvalho_2010_MEQ.pdf: 3051803 bytes, checksum: 7956a4f144fa95317239da7e0a92da3f (MD5) Previous issue date: 2010
Published: 2010

29. Deficiência na desidrogenase dos ésteres acil-coenzima A de cadeia média numa população portuguesa: caracterização molecular e funcional

Author: Luz, Andreia Rocha Custódio da, 1976, Ventura, Fátima, and Meireles, Margarida, 1955
Subjects: Metabolismo lipidico, Teses de mestrado - 2010, Doença autossómica, Biologia molecular
Abstract: Tese de mestrado. Biologia (Biologia Molecular Humana). Universidade de Lisboa, Faculdade de Ciências, 2010 Submitted by Lurdes Saramago (lurdes.saramago@fc.ul.pt) on 2011-02-14T16:22:54Z No. of bitstreams: 1 ulfc090574_tm_Andreia_Luz.pdf: 6033434 bytes, checksum: 2100e018d5333f4b7562c940998b2252 (MD5) Made available in DSpace on 2011-02-14T16:23:19Z (GMT). No. of bitstreams: 1 ulfc090574_tm_Andreia_Luz.pdf: 6033434 bytes, checksum: 2100e018d5333f4b7562c940998b2252 (MD5) Previous issue date: 2010
Published: 2010

30. On developing wellness and medical tourism: The characterization of a national thermal network

Author: Andreia Rocha and Antonio Brandao
Subjects: Leadership and Management, Health Policy
Published: 2014
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31. Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model

Author: Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Elaine Elisabetsky, and Diogo O. Souza
Subjects: major depressive disorder, psychopharmacology, purines (source: MeSH), guanosine, purinergic signaling, olfactory bulbectomy, Psychiatry, RC435-571
Abstract: Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness. When acutely administered, the endogenous nucleoside guanosine (GUO) shows fast-onset antidepressant-like effects in several mouse models, including the olfactory bulbectomy (OBX) rodent model. OBX is advocated to possess translational value and be suitable to assess the time course of depressive-like behavior in rodents. This study aimed at investigating the long-term behavioral and neurochemical effects of GUO in a mouse model of depression induced by bilateral bulbectomy (OBX). Mice were submitted to OBX and, after 14 days of recovery, received daily (ip) administration of 7.5 mg/kg GUO or 40 mg/kg imipramine (IMI) for 45 days. GUO and IMI reversed the OBX-induced hyperlocomotion and recognition memory impairment, hippocampal BDNF increase, and redox imbalance (ROS, NO, and GSH levels). GUO also mitigated the OBX-induced hippocampal neuroinflammation (IL-1, IL-6, TNF-α, INF-γ, and IL-10). Brain microPET imaging ([18F]FDG) shows that GUO also prevented the OBX-induced increase in hippocampal FDG metabolism. These results provide additional evidence for GUO antidepressant-like effects, associated with beneficial neurochemical outcomes relevant to counteract depression.
Published: 2021
Full Text: View/download PDF

32. Association Between Helicobacter pylori Infection and Cirrhosis in Patients with Chronic Hepatitis C Virus.

Author: Dulciene Queiroz, Andreia Rocha, Gifone Rocha, Sarah Cinque, Adriana Oliveira, Alicia Godoy, and Hugo Tanno
Abstract: We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20–78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06–5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00–1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus. [ABSTRACT FROM AUTHOR]
Published: 2006

33. Aspeto estético visual e inovação tecnológica no prazer das marcas de luxo : Caso Tesla

Author: Martins, Cátia Andreia Rocha and Rodrigues, Paula Cristina Lopes
Subjects: Gestão, Comportamento do Consumidor, Aspectos Sociais, Gestão da marca, Consumidores, Marcas
Abstract: Exame público realizado em 3 de junho de 2020, 11h00 Dissertação de mestrado em Gestão

34. Perfeccionismo e distress psicológico : prevenção no ensino superior

Author: Oliveira, Carla Andreia Rocha de, Pereira, Anabela Sousa, and Silva, Inês Cristina Direito Baptista da
Subjects: Psicologia clínica, Psicologia do desenvolvimento, Pefeccionismo, Distress Psicológico, Stresse (Psicologia), Depressão, Ensino Superior, Alunos do superior, Prevenção, Prevenção da doença, Estudantes Universitários
Abstract: Mestrado em Psicologia - Psicologia Clínica e da Saúde No contexto universitário tem-se vindo a observar uma preocupante prevalência de sintomatologia associada ao perfeccionismo, depressão e distress psicológico entre os estudantes do ensino superior. O presente estudo tem como principais objectivos caracterizar a população universitária quanto ao perfeccionismo, sintomatologia depressiva e distress psicológico e a relação entre o perfeccionismo e as restantes variáveis. Também se considerou a opinião dos estudantes quanto à pertinência de programas de prevenção nas instituições de ensino superior. No estudo participaram 254 estudantes de várias Universidades do país. Os instrumentos de avaliação utilizados foram a Escala Multidimensional do Perfeccionismo (EMP); o Questionário sobre a Saúde do Paciente (PHQ9) e a Escala do Distress Psicológico do Kessler (K10). Adicionalmente foi também aplicado um breve questionário no âmbito dos programas de prevenção. Os resultados sugeriram níveis significativamente elevados de sintomatologia depressiva e distress psicológico nos estudantes que referiram ter perturbação mental e aqueles que estão a ter acompanhamento. Observou-se também correlações significativas entre o perfeccionismo e a sintomatologia depressiva e distress psicológico. Os estudantes também parecem reconhecer a importância de programas de prevenção. Este estudo parece sugerir a existência de determinados grupos de estudantes em maior sofrimento psicológico, e portanto em maior risco, em comparação com os estudantes em geral. Observando-se uma relação entre as variáveis em estudo, aponta-se para uma possível influência do perfeccionismo no sofrimento psicológico dos estudantes. Neste sentido, tendo em conta os resultados obtidos, sublinha-se a importância da prevenção neste contexto, considerando-se a sua aplicação através da internet uma via bastante promissora. It has been possible to observe, in university context, a worrying prevalence of symptoms associated with perfectionism, depression and psychological distress in university students. The present study has as main goals to characterize the university population in variables such as perfectionism, depressive symptomatology and psychological distress, and the relation between perfectionism and the other remain variables. It was also considered the opinion of students of the importance of prevention programs in university institutions. In this study participated 254 students from various universities along the country. The instruments used were the Multidimensional Perfectionism Scale (MPS); the Patient Health Questionnaire 9 (PHQ-9) and Kessler Psychological Distress Scale (K10). Additionally, it was also used a brief questionnaire exploring prevention programs. The results suggested significantly elevated levels of depressive symptomology and distress in students that referred having a mental disorder and are attending psychological counseling. It was also observed significant correlations between perfectionism and depressive symptomatology and distress. Students seem to recognize the importance of prevention programs. This study seems to suggest the existence of particular groups of students in higher emotional suffering, and so in greater risk, in comparison with students in general. By observing the relation between the variables in this study, we highlight the importance of prevention in this context, considering the application via internet promising.

35. A RELEVÂNCIA DOS CENÁRIOS NA CONSTRUÇÃO DE UMA ANIMAÇÃO

Author: Dantas, Lina Andreia Rocha and Albino, Manuel António Carneiro Gaspar de Melo
Subjects: cenários, cor, Animação, narrativa, luz, som
Abstract: Apesar de muitas vezes ser entendido como um elemento decorativo de uma animação, o cenário pode e deve tomar parte ativa no decurso diegético. É inquestionável que as personagens são o foco principal no cinema de animação, no entanto, a audiência não é somente influenciada pelas figuras em primeiro plano, o modo como a topologia dos cenários descreve o local em que habitam, o modo como a luz, a cor, o som ou os adereços de um cenário refletem os sentimentos e personalidades, ou o modo como, por vezes, o cenário age sobre o decurso da história, ou reage às ações de personagens, indica a sua relevância. Este relatório visa estudar o potencial narrativo, emocional e expressivo dos cenários em cinema de animação, através da análise de longas-metragens, curtas-metragens e séries de animação. Estas questões, por sua vez, estão a ser aplicadas e analisadas no projeto transmidia, denominado “GOSMA!”.

36. Sistema de monitorização de dados clínicos no âmbito do LabEP

Author: Rodrigues, Cátia Andreia Rocha, Pereira, Pedro Miguel dos Santos Beça, Brandão, Maria Piedade, and Couto, Pedro Miguel Ferreira de Sá
Subjects: Gestão de bases de dados, Informatização de dados clínicos, Comunicação multimédia, Análise de dados, Novas tecnologias - Medicina, Prevenção e deteção prematura de doenças detetáveis, Monitorização de dados clínicos, Vigilância epidemiológica, Manuseamento de dados, Medicina do trabalho
Abstract: Mestrado em Comunicação Multimédia À semelhança do que ocorreu nos restantes domínios científicos, a tecnologia aplicada à medicina tem vindo a crescer, de forma que os novos meios de comunicação e interação passaram a fazer parte integrante de qualquer cenário comum da medicina. A Universidade de Aveiro (UA), no campo da medicina ocupacional, encontra-se um pouco aquém deste progresso no sentido em que os registos de dados das consultas não estão informatizados Esta dissertação permitiu a conceptualização de um projeto de um sistema de monitorização de dados clínicos no âmbito do Laboratório do Estudo de Populações (LabEP) na área da medicina do trabalho, especialmente pensado para o universo de trabalhadores relacionados com o ensino superior, nomeadamente no enquadramento teórico deste tipo de monitorização clínica, no levantamento de requisitos para um sistema de monitorização de dados que se adapte à realidade da UA. Este estudo foi desenvolvido em apoio ao projeto de investigação do LabEP “Vigilância dos fatores de risco para as doenças crónicas não transmissíveis na população de trabalhadores da Universidade de Aveiro”. Esta plataforma poderá vir a permitir uma melhor prevenção e intervenção mais atempada em relação a doenças cujos sintomas possam ser detetados prematuramente. Similarly to what occurred in the remaining scientific domains, the use of technology in the medical field has been growing in such way that the new communication and interaction methods have become part of any common medical scenario. University of Aveiro (UA) is still not up to date in terms of occupational medicine, in the sense that the medical data issued during those sessions does not get converted into an electronic format. This dissertation allowed a project conceptualization consisting in a control system for medical data, integrated in the Laboratório do Estudo de Populações (LabEP) for the occupational medicine field, specifically created for superior education workers in the theoretical part of this medical control system, in the definition of requirements for a data control system that would be appropriate for University of Aveiro’s reality. This study has been developed in support of LabEp’s research project “Vigilância dos fatores de risco para as doenças crónicas não transmissíveis na população de trabalhadores da Universidade de Aveiro”. This platform will potentially allow for a better prevention and timely intervention on diseases from which symptoms can be detected prematurely.

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