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1. MITO END-3: efficacy of avelumab immunotherapy according to molecular profiling in first-line endometrial cancer therapy

Author

Pignata, S., Califano, D., Lorusso, D., Arenare, L., Bartoletti, M., De Giorgi, U., Andreetta, C., Pisano, C., Scambia, G., Lombardi, D., Farolfi, A., Cinieri, S., Passarelli, A., Salutari, V., De Angelis, C., Mignogna, C., Priolo, D., Capoluongo, E.D., Tamberi, S., Scaglione, G.L., Arcangeli, V., De Cecio, R., Scognamiglio, G., Greco, F., Spina, A., Turinetto, M., Russo, D., Carbone, V., Casartelli, C., Schettino, C., and Perrone, F.

Published
2024
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2. Single-Agent Trabectedin Versus Physician's Choice Chemotherapy in Patients With Recurrent Ovarian Cancer With BRCA -Mutated and/or BRCAness Phenotype: A Randomized Phase III Trial

Author

Lorusso, D, Raspagliesi, F, Ronzulli, D, Valabrega, G, Colombo, N, Pisano, C, Cassani, C, Tognon, G, Tamberi, S, Mangili, G, Mammoliti, S, De Giorgi, U, Greco, F, Mosconi, A, Breda, E, Artioli, G, Andreetta, C, Casanova, C, Ceccherini, R, Frassoldati, A, Salutari, V, Giolitto, S, Scambia, G, Lorusso D., Raspagliesi F., Ronzulli D., Valabrega G., Colombo N., Pisano C., Cassani C., Tognon G., Tamberi S., Mangili G., Mammoliti S., De Giorgi U., Greco F., Mosconi A. M., Breda E., Artioli G., Andreetta C., Casanova C., Ceccherini R., Frassoldati A., Salutari V., Giolitto S., Scambia G., Lorusso, D, Raspagliesi, F, Ronzulli, D, Valabrega, G, Colombo, N, Pisano, C, Cassani, C, Tognon, G, Tamberi, S, Mangili, G, Mammoliti, S, De Giorgi, U, Greco, F, Mosconi, A, Breda, E, Artioli, G, Andreetta, C, Casanova, C, Ceccherini, R, Frassoldati, A, Salutari, V, Giolitto, S, Scambia, G, Lorusso D., Raspagliesi F., Ronzulli D., Valabrega G., Colombo N., Pisano C., Cassani C., Tognon G., Tamberi S., Mangili G., Mammoliti S., De Giorgi U., Greco F., Mosconi A. M., Breda E., Artioli G., Andreetta C., Casanova C., Ceccherini R., Frassoldati A., Salutari V., Giolitto S., and Scambia G.

Abstract

PURPOSELiterature evidence suggests that trabectedin monotherapy is effective in patients with recurrent ovarian cancer (OC) presenting BRCA mutation and/or BRCAness phenotype.METHODSA prospective, open-label, randomized phase III MITO-23 trial evaluated the activity and safety of trabectedin 1.3 mg/m2 given once every 3 weeks (arm A) in BRCA 1/2 mutation carriers or patients with BRCAness phenotype (ie, patients who responded to ≥two previous platinum-based treatments) with recurrent OC, primary peritoneal carcinoma, or fallopian tube cancer in comparison with physician's choice chemotherapy in the control arm (arm B; pegylated liposomal doxorubicin, topotecan, gemcitabine, once-weekly paclitaxel, or carboplatin). The primary end point was overall survival (OS) evaluated in the intention-to-treat population.RESULTSOverall, 244 patients from 21 MITO centers were randomly assigned (arm A = 122/arm B = 122). More than 70% of patients received ≥three previous chemotherapy lines and 35.7% had received a poly (ADP-ribose) polymerase inhibitor (PARPi) before enrollment. Median OS was not significantly different between the arms: arm A: 15.8 versus arm B: 17.9 months (P =.304). Median progression-free survival was 4.9 months in arm A versus 4.4 months in arm B (P =.897). Among 208 patients evaluable for efficacy, the objective response rate was 17.1% in arm A and 21.4% in arm B, with comparable median duration of response (5.62 v 5.66 months, respectively). No superior effect was observed for trabectedin in the prespecified subgroup analyses according to BRCA mutational status, chemotherapy type, and pretreatment with a PARPi and/or platinum-free interval. Trabectedin showed a higher frequency of grade ≥3 adverse events (AEs), serious AEs, and serious adverse drug reactions compared with control chemotherapy.CONCLUSIONTrabectedin did not improve median OS and showed a worse safety profile in comparison with physician's choice control chemotherapy.

Published
2024

3. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author

Bachelot, T., Bouzid, K., Campone, M., Desmoulins, I., Coudert, B., Bondarenko, I., Nowecki, Z., Glogowska, I., Ciruelos Gil, E., Errihani, H., Dalenc, F., Ricci, F., Dieras, V., Kaufman, B., Paluch-Shimon, S., Wardley, A., Schneeweiss, A., Ferreira, A., Mano, M., Kalofonos, H., Andreetta, C., Puglisi, F., Montemurro, F., Barrett, S., Zhang, Q., Mavroudis, D., Matus, J., Villarreal Garza, C., Beato, C., Ismael, G., Hu, X., Abdel Azeem, H., Gaafar, R., Perrin, C., Kerbrat, P., Ettl, J., Paepke, S., Hitre, E., Lang, I., Trudeau, M., Verma, S., Li, H., Hoffmann, O., Aktas, B., Cariello, A., Cruciani, G., Tienghi, A., Tondini, C., Al-Twegieri, T., Loman, N., Laing, R., Miles, D., Brain, E., Fasching, P., Lux, M., Frassoldati, A., Aziz, Z., Salas, J., Streb, J., Krzemieniecki, K., Wronski, A., Garcia Garcia, J., Menjon Beltran, S., Cicin, I., Schmid, P., Gallagher, C., Turner, N., Tong, Z., Boer, K., Juhász, B., Horvath, Z., Bianchini, G., Gianni, L., Curigliano, G., Juarez Ramiro, A., Susnjar, S., Matos, E., Sevillano, E., Garcia Estevez, L., Gokmen, E., Uslu, R., Wildiers, H., Schutz, F., Cruz, M., Bourgeois, H., von Schumann, R., Stemmer, S., Dominguez, A., Morales-Vásques, F., Wojtukiewicz, M., Trifunovic, J., Echarri Gonzalez, M.J., Illarramendi Mañas, J., Martinez De Dueñas, E., Voitko, N., Hicks, J., Waters, S., Barrett-Lee, P., Wheatley, D., De Boer, R., Cocquyt, V., Jerusalem, G., Barrios, C., Panasci, L., Mattson, J., Tanner, M., Gozy, M., Vasilopoulos, G., Papandreou, C., Revesz, J., Battelli, N., Benedetti, G., Latini, L., Gridelli, C., Lazaro Leon, J., Alarcón Company, J., Arance Fernandez, A., Barnadas Molins, A., Calvo Plaza, I., Bratos, R., Gonzalez Martin, A., Izarzugaza Peron, Y., Klint, L., Kovalev, A., McCarthy, N., Yeo, B., Kee, D., Thomson, J., White, S., Greil, R., Wang, S., Artignan, X., Juhasz-Böess, I., Rody, A., Ngan, R., Dourleshter, F., Goldberg, H., Doni, L., Di Costanzo, F., Ferraù, F., Drobniene, M., Aleknavicius, E., Rashid, K., Costa, L., de la Cruz Merino, L., Garcia Saenz, J., López, R., Del Val Munoz, O., Ozyilkan, O., Azribi, F., Jaafar, H., Baird, R., Verrill, M., Beith, J., Petzer, A., Moreira de Andrade, J., Bernstein, V., Macpherson, N., Rayson, D., Saad Eldin, I., Achille, M., Augereau, P., Müller, V., Rasco, A., Evron, E., Katz, D., Berardi, R., Cascinu, S., De Censi, A., Gennari, A., El-Saghir, N., Ghosn, M., Oosterkamp, H.M., Van den Bosch, J., Kukulska, M., Kalinka, E., Alonso, J., Dalmau Portulas, E., Del Mar Gordon Santiago, M., Pelaez Fernandez, I., Aksoy, S., Altundag, K., Senol Coskun, H., Bozcuk, H., Shparyk, Y., Barraclough, L., Levitt, N., Panwar, U., Kelly, S., Rigg, A., Varughese, M., Castillo, C., Fein, L., Malik, L., Stuart-Harris, R., Singer, C., Stoeger, H., Samonigg, H., Feng, J., Cedeño, M., Ruohola, J., Berdah, J.-F., Goncalves, A., Orfeuvre, H., Grischke, E.-M., Simon, E., Wagner, S., Koumakis, G., Papazisis, K., Ben Baruch, N., Fried, G., Geffen, D., Karminsky, N., Peretz, T., Cavanna, L., Pedrazzioli, P., Grasso, D., Ruggeri, E., D’Auria, G., Moscetti, L., Juozaityte, E., Rodriguez Cid, J., Roerdink, H., Siddiqi, N., Passos Coelho, J., Arcediano Del Amo, A., Garcia Garre, E., García Gonzalez, M., Garcia-Palomo Perez, A., Herenandez Perez, C., Lopez Alvarez, P., Lopez De Ceballos, M.H., Martínez Jañez, N., Mele Olive, M., McAdam, K., Perren, T., Dunn, G., Humphreys, A., Taylor, W., Vera, R., Kaen, L., Andel, J., Steger, G., De Grève, J., Huizing, M., Hegg, R., Joy, A., Kuruvilla, P., Sehdev, S., Smiljanic, S., Kütner, R., Alexandre, J., Grosjean, J., Laplaige, P., Largillier, R., Maes, P., Martin, P., Pottier, V., Christensen, B., Khandan, F., Lück, H.-J., Zahm, D.-M., Fountzilas, G., Karavasilis, V., Safra, T., Inbar, M., Ryvo, L., Bonetti, A., Seles, E., Giacobino, A., Chavarri Guerra, Y., de Jongh, F., van der Velden, A., van Warmerdam, L., Vrijaldenhoven, S., Smorenburg, C.H., Cavero, M., Andres Conejero, R., Oltra Ferrando, A., Redondo Sanchez, A., Ribelles Entrena, N., Saura Grau, S., Viñas Vilaro, G., Bachmeier, K., Beresford, M., Butt, M., Joffe, J., Poole, C., Woodings, P., Chakraborti, P., Yordi, G., Woodward, N., Nobre, A., Luiz Amorim, G., Califaretti, N., Fox, S., Robidoux, A., Li, E., Li, N., Jiang, J., Soria, T., Padrik, P., Lahdenpera, O., Barletta, H., Dohollou, N., Genet, D., Prulhiere, K., Coeffic, D., Facchini, T., Vieillot, S., Catala, S., Teixeira, L., Hesse, T., Kühn, T., Ober, A., Repp, R., Schröder, W., Pectasides, D., Bodoky, G., Kahan, Z., Jiveliouk, I., Rosengarten, O., Rossi, V., Alabiso, O., Pérez Martínez, M., van de Wouw, A.J., Smok-Kalwat, J., Damasecno, M., Augusto, I., Sousa, G., Saadein, A., Abdelhafiez, N., Abulkhair, O., Antón Torres, A., Corbellas Aparicio, M., Llorente Domenech, R., Florián Jerico, J., Garcia Mata, J., Gil Raga, M., Galan Brotons, A., Llombart Cussac, A., Llorca Ferrandiz, C., Martinez Del Prado, P., Olier Garate, C., Rodriguez Sanchez, C., Sanchez Gomez, R., Santisteban Eslava, M., Soberino, J., Vidal Losada Garcia, M., Soto de Prado, D., Torrego Garcia, J., Vicente Rubio, E., Garcia, M., Murias Rosales, A., Granstam Björneklett, H., Narbe, U., Jafri, M., Rea, D., Newby, J., Jones, A., Westwell, S., Ring, A., Alonso, I., Rodríguez, R., Ciruelos, E., Peretz-Yablonski, T., Merot, J.-L., Trask, P., du Toit, Y., Pena-Murillo, C., Revelant, V., and Klingbiel, D.

Published
2021
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4. Carboplatin and paclitaxel plus avelumab compared with carboplatin and paclitaxel in advanced or recurrent endometrial cancer (MITO END-3): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Pignata, S, Scambia, G, Schettino, C, Arenare, L, Pisano, C, Lombardi, D, De Giorgi, U, Andreetta, C, Cinieri, S, De Angelis, C, Priolo, D, Casanova, C, Rosati, M, Greco, F, Zafarana, E, Schiavetto, I, Mammoliti, S, Cecere, S, Salutari, V, Scalone, S, Farolfi, A, Di Napoli, M, Lorusso, D, Gargiulo, P, Califano, D, Russo, D, Spina, A, De Cecio, R, Chiodini, P, Perrone, F, Accinno, V, Altavilla, C, Antonelli, G, Artioli, G, Avola, F, Barbara, B, Barbato, V, Bartoletti, M, Bevilacqua, S, Bordonaro, R, Borghese, O, Buonfanti, G, Camarda, F, Canzanella, G, Carbone, V, Carbone, M, Carlo Stella, G, Cassani, C, Castagna, F, Cattaneo, M, Cinefra, M, Colombo, N, Corsetti, S, Dall'Agata, M, D'Amico, M, Daniele, G, De Marino, E, De Matteis, G, De Placido, S, Del Bene, G, Del Giudice, A, Del Monte, F, Del Sesto, M, Donini, M, Drudi, G, Falcone, G, Favaretto, A, Ferrera, G, Florio, M, Forestieri, V, Gallo, M, Gallo, C, Garibaldi, F, Gerevini, F, Ghizzoni, V, Giganti, M, Gimigliano, A, Giudice, E, Gnocchi, N, Gravina, A, Greggi, S, Iaia, M, Ilardi, A, Iovine, G, Ippoliti, G, Irollo, G, Isidori, I, Lapresa, M, Lavenia, G, Longhitano, L, Lucia, B, Luzi, G, Mariano, S, Marino, V, Marrapese, G, Martino, M, Matocci, R, Mazzoni, E, Mercuri, D, Mirto, M, Pignata S., Scambia G., Schettino C., Arenare L., Pisano C., Lombardi D., De Giorgi U., Andreetta C., Cinieri S., De Angelis C., Priolo D., Casanova C., Rosati M., Greco F., Zafarana E., Schiavetto I., Mammoliti S., Cecere S. C., Salutari V., Scalone S., Farolfi A., Di Napoli M., Lorusso D., Gargiulo P., Califano D., Russo D., Spina A., De Cecio R., Chiodini P., Perrone F., Accinno V., Altavilla C., Antonelli G., Artioli G., Avola F., Barbara B., Barbato V., Bartoletti M., Bevilacqua S., Bordonaro R., Borghese O., Buonfanti G., Camarda F., Canzanella G., Carbone V., Carbone M. R., Carlo Stella G., Cassani C., Castagna F., Cattaneo M., Cinefra M., Colombo N., Corsetti S., Dall'Agata M., D'Amico M., Daniele G., De Marino E., De Matteis G., De Placido S., Del Bene G., Del Giudice A., Del Monte F., Del Sesto M., Donini M., Drudi G., Falcone G., Favaretto A., Ferrera G., Florio M., Forestieri V., Gallo M. S., Gallo C., Garibaldi F., Gerevini F., Ghizzoni V., Giganti M. O., Gimigliano A., Giudice E., Gnocchi N., Gravina A., Greggi S., Iaia M. L., Ilardi A., Iovine G., Ippoliti G., Irollo G., Isidori I., Lapresa M., Lavenia G., Longhitano L., Lucia B., Luzi G., Mariano S., Marino V., Marrapese G., Martino M., Matocci R., Mazzoni E., Mercuri D., Mirto M., Pignata, S, Scambia, G, Schettino, C, Arenare, L, Pisano, C, Lombardi, D, De Giorgi, U, Andreetta, C, Cinieri, S, De Angelis, C, Priolo, D, Casanova, C, Rosati, M, Greco, F, Zafarana, E, Schiavetto, I, Mammoliti, S, Cecere, S, Salutari, V, Scalone, S, Farolfi, A, Di Napoli, M, Lorusso, D, Gargiulo, P, Califano, D, Russo, D, Spina, A, De Cecio, R, Chiodini, P, Perrone, F, Accinno, V, Altavilla, C, Antonelli, G, Artioli, G, Avola, F, Barbara, B, Barbato, V, Bartoletti, M, Bevilacqua, S, Bordonaro, R, Borghese, O, Buonfanti, G, Camarda, F, Canzanella, G, Carbone, V, Carbone, M, Carlo Stella, G, Cassani, C, Castagna, F, Cattaneo, M, Cinefra, M, Colombo, N, Corsetti, S, Dall'Agata, M, D'Amico, M, Daniele, G, De Marino, E, De Matteis, G, De Placido, S, Del Bene, G, Del Giudice, A, Del Monte, F, Del Sesto, M, Donini, M, Drudi, G, Falcone, G, Favaretto, A, Ferrera, G, Florio, M, Forestieri, V, Gallo, M, Gallo, C, Garibaldi, F, Gerevini, F, Ghizzoni, V, Giganti, M, Gimigliano, A, Giudice, E, Gnocchi, N, Gravina, A, Greggi, S, Iaia, M, Ilardi, A, Iovine, G, Ippoliti, G, Irollo, G, Isidori, I, Lapresa, M, Lavenia, G, Longhitano, L, Lucia, B, Luzi, G, Mariano, S, Marino, V, Marrapese, G, Martino, M, Matocci, R, Mazzoni, E, Mercuri, D, Mirto, M, Pignata S., Scambia G., Schettino C., Arenare L., Pisano C., Lombardi D., De Giorgi U., Andreetta C., Cinieri S., De Angelis C., Priolo D., Casanova C., Rosati M., Greco F., Zafarana E., Schiavetto I., Mammoliti S., Cecere S. C., Salutari V., Scalone S., Farolfi A., Di Napoli M., Lorusso D., Gargiulo P., Califano D., Russo D., Spina A., De Cecio R., Chiodini P., Perrone F., Accinno V., Altavilla C., Antonelli G., Artioli G., Avola F., Barbara B., Barbato V., Bartoletti M., Bevilacqua S., Bordonaro R., Borghese O., Buonfanti G., Camarda F., Canzanella G., Carbone V., Carbone M. R., Carlo Stella G., Cassani C., Castagna F., Cattaneo M., Cinefra M., Colombo N., Corsetti S., Dall'Agata M., D'Amico M., Daniele G., De Marino E., De Matteis G., De Placido S., Del Bene G., Del Giudice A., Del Monte F., Del Sesto M., Donini M., Drudi G., Falcone G., Favaretto A., Ferrera G., Florio M., Forestieri V., Gallo M. S., Gallo C., Garibaldi F., Gerevini F., Ghizzoni V., Giganti M. O., Gimigliano A., Giudice E., Gnocchi N., Gravina A., Greggi S., Iaia M. L., Ilardi A., Iovine G., Ippoliti G., Irollo G., Isidori I., Lapresa M., Lavenia G., Longhitano L., Lucia B., Luzi G., Mariano S., Marino V., Marrapese G., Martino M., Matocci R., Mazzoni E., Mercuri D., and Mirto M.

Published
2023

6. Management of Patients Diagnosed with Endometrial Cancer: Comparison of Guidelines

Author

Restaino, S., Paglietti, C., Arcieri, M., Biasioli, A., Della Martina, M., Mariuzzi, L., Andreetta, C., Titone, F., Bogani, G., Raimondo, D., Perelli, F., Buda, A., Petrillo, M., Greco, P., Ercoli, A., Fanfani, Francesco, Scambia, Giovanni, Driul, L., Vizzielli, G., Fanfani F. (ORCID:0000-0003-1991-7284), Scambia G. (ORCID:0000-0003-2758-1063), Restaino, S., Paglietti, C., Arcieri, M., Biasioli, A., Della Martina, M., Mariuzzi, L., Andreetta, C., Titone, F., Bogani, G., Raimondo, D., Perelli, F., Buda, A., Petrillo, M., Greco, P., Ercoli, A., Fanfani, Francesco, Scambia, Giovanni, Driul, L., Vizzielli, G., Fanfani F. (ORCID:0000-0003-1991-7284), and Scambia G. (ORCID:0000-0003-2758-1063)

Abstract

Endometrial cancer is the most common gynecological malignancy in Europe and its management involves a variety of health professionals. In recent years, big discoveries were made concerning the management of patients diagnosed with endometrial cancer, particularly in the field of molecular biology and minimally invasive surgery. This requires the continuous updating of guidelines and protocols over the years. In this paper, we aim to summarize and compare common points and disparities among protocols for management of patients diagnosed with endometrial cancer by leading international gynecological oncological societies. We therefore systematically report the parallel among the guidelines based on the various steps patients with endometrial cancer usually undergo. The comparison between American and European protocols revealed some relevant disparities, in particular regarding surgical staging, molecular biology application as a prognostic tool and follow up regimens. This could possibly cause differences in interpreting and applying protocols in clinical practice in small centers, leading to a lack of adherence to guidelines or even prompting a confusing mix of them.

Published
2023

7. 590P Ki67 as a predictor of response to PARP inhibitors in platinum sensitive BRCA wild type ovarian cancers: MITO 37 retrospective study

Author

Tuninetti, V., primary, Ghisoni, E., additional, Pignata, S., additional, Picardo, E., additional, Raspagliesi, F., additional, Andreetta, C., additional, Maldi, E., additional, Artioli, G., additional, Mammoliti, S., additional, Roccio, M., additional, Sikokis, A., additional, Biglia, N., additional, Parisi, A., additional, Mandato, V.D., additional, Carella, C., additional, Cormio, G., additional, Marinaccio, M., additional, Scotto, G., additional, Di Maio, M., additional, and Valabrega, G., additional

Published
2022
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11. Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Author

Miles, D., primary, Ciruelos, E., additional, Schneeweiss, A., additional, Puglisi, F., additional, Peretz-Yablonski, T., additional, Campone, M., additional, Bondarenko, I., additional, Nowecki, Z., additional, Errihani, H., additional, Paluch-Shimon, S., additional, Wardley, A., additional, Merot, J.-L., additional, Trask, P., additional, du Toit, Y., additional, Pena-Murillo, C., additional, Revelant, V., additional, Klingbiel, D., additional, Bachelot, T., additional, Bouzid, K., additional, Desmoulins, I., additional, Coudert, B., additional, Glogowska, I., additional, Ciruelos Gil, E., additional, Dalenc, F., additional, Ricci, F., additional, Dieras, V., additional, Kaufman, B., additional, Ferreira, A., additional, Mano, M., additional, Kalofonos, H., additional, Andreetta, C., additional, Montemurro, F., additional, Barrett, S., additional, Zhang, Q., additional, Mavroudis, D., additional, Matus, J., additional, Villarreal Garza, C., additional, Beato, C., additional, Ismael, G., additional, Hu, X., additional, Abdel Azeem, H., additional, Gaafar, R., additional, Perrin, C., additional, Kerbrat, P., additional, Ettl, J., additional, Paepke, S., additional, Hitre, E., additional, Lang, I., additional, Trudeau, M., additional, Verma, S., additional, Li, H., additional, Hoffmann, O., additional, Aktas, B., additional, Cariello, A., additional, Cruciani, G., additional, Tienghi, A., additional, Tondini, C., additional, Al-Twegieri, T., additional, Loman, N., additional, Laing, R., additional, Miles, D., additional, Brain, E., additional, Fasching, P., additional, Lux, M., additional, Frassoldati, A., additional, Aziz, Z., additional, Salas, J., additional, Streb, J., additional, Krzemieniecki, K., additional, Wronski, A., additional, Garcia Garcia, J., additional, Menjon Beltran, S., additional, Cicin, I., additional, Schmid, P., additional, Gallagher, C., additional, Turner, N., additional, Tong, Z., additional, Boer, K., additional, Juhász, B., additional, Horvath, Z., additional, Bianchini, G., additional, Gianni, L., additional, Curigliano, G., additional, Juarez Ramiro, A., additional, Susnjar, S., additional, Matos, E., additional, Sevillano, E., additional, Garcia Estevez, L., additional, Gokmen, E., additional, Uslu, R., additional, Wildiers, H., additional, Schutz, F., additional, Cruz, M., additional, Bourgeois, H., additional, von Schumann, R., additional, Stemmer, S., additional, Dominguez, A., additional, Morales-Vásques, F., additional, Wojtukiewicz, M., additional, Trifunovic, J., additional, Echarri Gonzalez, M.J., additional, Illarramendi Mañas, J., additional, Martinez De Dueñas, E., additional, Voitko, N., additional, Hicks, J., additional, Waters, S., additional, Barrett-Lee, P., additional, Wheatley, D., additional, De Boer, R., additional, Cocquyt, V., additional, Jerusalem, G., additional, Barrios, C., additional, Panasci, L., additional, Mattson, J., additional, Tanner, M., additional, Gozy, M., additional, Vasilopoulos, G., additional, Papandreou, C., additional, Revesz, J., additional, Battelli, N., additional, Benedetti, G., additional, Latini, L., additional, Gridelli, C., additional, Lazaro Leon, J., additional, Alarcón Company, J., additional, Arance Fernandez, A., additional, Barnadas Molins, A., additional, Calvo Plaza, I., additional, Bratos, R., additional, Gonzalez Martin, A., additional, Izarzugaza Peron, Y., additional, Klint, L., additional, Kovalev, A., additional, McCarthy, N., additional, Yeo, B., additional, Kee, D., additional, Thomson, J., additional, White, S., additional, Greil, R., additional, Wang, S., additional, Artignan, X., additional, Juhasz-Böess, I., additional, Rody, A., additional, Ngan, R., additional, Dourleshter, F., additional, Goldberg, H., additional, Doni, L., additional, Di Costanzo, F., additional, Ferraù, F., additional, Drobniene, M., additional, Aleknavicius, E., additional, Rashid, K., additional, Costa, L., additional, de la Cruz Merino, L., additional, Garcia Saenz, J., additional, López, R., additional, Del Val Munoz, O., additional, Ozyilkan, O., additional, Azribi, F., additional, Jaafar, H., additional, Baird, R., additional, Verrill, M., additional, Beith, J., additional, Petzer, A., additional, Moreira de Andrade, J., additional, Bernstein, V., additional, Macpherson, N., additional, Rayson, D., additional, Saad Eldin, I., additional, Achille, M., additional, Augereau, P., additional, Müller, V., additional, Rasco, A., additional, Evron, E., additional, Katz, D., additional, Berardi, R., additional, Cascinu, S., additional, De Censi, A., additional, Gennari, A., additional, El-Saghir, N., additional, Ghosn, M., additional, Oosterkamp, H.M., additional, Van den Bosch, J., additional, Kukulska, M., additional, Kalinka, E., additional, Alonso, J., additional, Dalmau Portulas, E., additional, Del Mar Gordon Santiago, M., additional, Pelaez Fernandez, I., additional, Aksoy, S., additional, Altundag, K., additional, Senol Coskun, H., additional, Bozcuk, H., additional, Shparyk, Y., additional, Barraclough, L., additional, Levitt, N., additional, Panwar, U., additional, Kelly, S., additional, Rigg, A., additional, Varughese, M., additional, Castillo, C., additional, Fein, L., additional, Malik, L., additional, Stuart-Harris, R., additional, Singer, C., additional, Stoeger, H., additional, Samonigg, H., additional, Feng, J., additional, Cedeño, M., additional, Ruohola, J., additional, Berdah, J.-F., additional, Goncalves, A., additional, Orfeuvre, H., additional, Grischke, E.-M., additional, Simon, E., additional, Wagner, S., additional, Koumakis, G., additional, Papazisis, K., additional, Ben Baruch, N., additional, Fried, G., additional, Geffen, D., additional, Karminsky, N., additional, Peretz, T., additional, Cavanna, L., additional, Pedrazzioli, P., additional, Grasso, D., additional, Ruggeri, E., additional, D’Auria, G., additional, Moscetti, L., additional, Juozaityte, E., additional, Rodriguez Cid, J., additional, Roerdink, H., additional, Siddiqi, N., additional, Passos Coelho, J., additional, Arcediano Del Amo, A., additional, Garcia Garre, E., additional, García Gonzalez, M., additional, Garcia-Palomo Perez, A., additional, Herenandez Perez, C., additional, Lopez Alvarez, P., additional, Lopez De Ceballos, M.H., additional, Martínez Jañez, N., additional, Mele Olive, M., additional, McAdam, K., additional, Perren, T., additional, Dunn, G., additional, Humphreys, A., additional, Taylor, W., additional, Vera, R., additional, Kaen, L., additional, Andel, J., additional, Steger, G., additional, De Grève, J., additional, Huizing, M., additional, Hegg, R., additional, Joy, A., additional, Kuruvilla, P., additional, Sehdev, S., additional, Smiljanic, S., additional, Kütner, R., additional, Alexandre, J., additional, Grosjean, J., additional, Laplaige, P., additional, Largillier, R., additional, Maes, P., additional, Martin, P., additional, Pottier, V., additional, Christensen, B., additional, Khandan, F., additional, Lück, H.-J., additional, Zahm, D.-M., additional, Fountzilas, G., additional, Karavasilis, V., additional, Safra, T., additional, Inbar, M., additional, Ryvo, L., additional, Bonetti, A., additional, Seles, E., additional, Giacobino, A., additional, Chavarri Guerra, Y., additional, de Jongh, F., additional, van der Velden, A., additional, van Warmerdam, L., additional, Vrijaldenhoven, S., additional, Smorenburg, C.H., additional, Cavero, M., additional, Andres Conejero, R., additional, Oltra Ferrando, A., additional, Redondo Sanchez, A., additional, Ribelles Entrena, N., additional, Saura Grau, S., additional, Viñas Vilaro, G., additional, Bachmeier, K., additional, Beresford, M., additional, Butt, M., additional, Joffe, J., additional, Poole, C., additional, Woodings, P., additional, Chakraborti, P., additional, Yordi, G., additional, Woodward, N., additional, Nobre, A., additional, Luiz Amorim, G., additional, Califaretti, N., additional, Fox, S., additional, Robidoux, A., additional, Li, E., additional, Li, N., additional, Jiang, J., additional, Soria, T., additional, Padrik, P., additional, Lahdenpera, O., additional, Barletta, H., additional, Dohollou, N., additional, Genet, D., additional, Prulhiere, K., additional, Coeffic, D., additional, Facchini, T., additional, Vieillot, S., additional, Catala, S., additional, Teixeira, L., additional, Hesse, T., additional, Kühn, T., additional, Ober, A., additional, Repp, R., additional, Schröder, W., additional, Pectasides, D., additional, Bodoky, G., additional, Kahan, Z., additional, Jiveliouk, I., additional, Rosengarten, O., additional, Rossi, V., additional, Alabiso, O., additional, Pérez Martínez, M., additional, van de Wouw, A.J., additional, Smok-Kalwat, J., additional, Damasecno, M., additional, Augusto, I., additional, Sousa, G., additional, Saadein, A., additional, Abdelhafiez, N., additional, Abulkhair, O., additional, Antón Torres, A., additional, Corbellas Aparicio, M., additional, Llorente Domenech, R., additional, Florián Jerico, J., additional, Garcia Mata, J., additional, Gil Raga, M., additional, Galan Brotons, A., additional, Llombart Cussac, A., additional, Llorca Ferrandiz, C., additional, Martinez Del Prado, P., additional, Olier Garate, C., additional, Rodriguez Sanchez, C., additional, Sanchez Gomez, R., additional, Santisteban Eslava, M., additional, Soberino, J., additional, Vidal Losada Garcia, M., additional, Soto de Prado, D., additional, Torrego Garcia, J., additional, Vicente Rubio, E., additional, Garcia, M., additional, Murias Rosales, A., additional, Granstam Björneklett, H., additional, Narbe, U., additional, Jafri, M., additional, Rea, D., additional, Newby, J., additional, Jones, A., additional, Westwell, S., additional, Ring, A., additional, Alonso, I., additional, and Rodríguez, R., additional

Published
2021
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12. 252P Does the introduction of CDK4/6 inhibitors (CDKi) in first-line treatment of metastatic breast cancer (MBC) increase medical oncology workload?

Author

Noto, C., primary, Dri, A., additional, Pravisano, F., additional, Residori, M., additional, Bortot, L., additional, Buriolla, S., additional, Targato, G., additional, Andreetta, C., additional, Pascoletti, G., additional, Poletto, E., additional, Russo, S., additional, Mansutti, M., additional, Minisini, A.M.M., additional, Puglisi, F., additional, Fasola, G., additional, and Bonotto, M., additional

Published
2021
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13. 295P Clinical characterization and outcome of a HER2-low metastatic breast cancer (mBC) cohort receiving first-line treatment (1L) with ET +/- CDK 4/6 inhibitor (CDKi)

Author

Bortot, L., primary, Basile, D., additional, Targato, G., additional, Zara, D., additional, Palmero, L., additional, Alberti, M., additional, Buriolla, S., additional, Noto, C., additional, Pascoletti, G., additional, Poletto, E., additional, Andreetta, C., additional, Russo, S., additional, Mansutti, M., additional, Gerratana, L., additional, Bonotto, M., additional, Fasola, G., additional, Puglisi, F., additional, and Minisini, A.M.M., additional

Published
2021
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15. Expression of periostin in human breast cancer

Author

Puglisi, F., Puppin, C., Pegolo, E., Andreetta, C., Pascoletti, G., D'Aurizio, F., Pandolfi, M., Fasola, G., Piga, A., Damante, G., and Di Loreto, C.

Subjects
Proteins -- Research, Proteins -- Physiological aspects, Breast cancer -- Research, Breast cancer -- Genetic aspects, Gene expression -- Research, Neovascularization -- Research, Neovascularization -- Physiological aspects, Health
Published
2008

16. 1741P Triage procedures for COVID-19 in an Italian cancer centre

Author

Targato, G., primary, Zara, D., additional, Fioraso, R., additional, Bortot, L., additional, Pelizzari, G., additional, Corvaja, C., additional, Palmero, L., additional, Puglisi, F., additional, Andreetta, C., additional, Cardellino, G.G., additional, Minisini, A.M., additional, and Fasola, G., additional

Published
2020
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18. EP795 Searching for the best maintenance therapy in platinum-sensitive recurrent ovarian cancer: bevacizumab or PARP-inhibitors? A network meta-analysis

Author

Bartoletti, M, primary, Pelizzari, G, additional, Bortot, L, additional, Giavarra, M, additional, Vitale, MG, additional, Andreotti, V, additional, Parnofiello, A, additional, Scalone, S, additional, Lombardi, D, additional, Nicoloso, M, additional, Bozza, C, additional, Poletto, E, additional, Sacco, C, additional, Andreetta, C, additional, Sorio, R, additional, and Puglisi, F, additional

Published
2019
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19. Clinical decision making and multidisciplinary team meetings (MDMs) in early breast cancer. Is the agreement between planned and applied therapeutic program?

Author

Giavarra, M., primary, Bertoli, E., additional, Buoro, V., additional, Zara, D., additional, Targato, G., additional, Palmero, L., additional, Vitale, M.G., additional, Pelizzari, G., additional, Basile, D., additional, Gerratana, L., additional, Bonotto, M., additional, Andreetta, C., additional, Cinausero, M., additional, Pascoletti, G., additional, Poletto, E., additional, Russo, S., additional, Puglisi, F., additional, Fasola, G., additional, Mansutti, M., additional, and Minisini, A.M., additional

Published
2019
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20. A risk score integrating lymphocytes ratios (LRs) and lactate dehydrogenase (LDH) levels to predict prognosis in metastatic breast cancer (MBC) patients

Author

Pelizzari, G., primary, Gerratana, L., additional, Basile, D., additional, Zago, S., additional, Vitale, M.G., additional, Bartoletti, M., additional, Lisanti, C., additional, Fanotto, V., additional, Corvaja, C., additional, Bortot, L., additional, Liguori, A., additional, Cinausero, M., additional, Russo, S., additional, Andreetta, C., additional, Bonotto, M., additional, Mansutti, M., additional, Minisini, A.M., additional, Curcio, F., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2018
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21. Monitoring metastatic breast cancer (M-MBC) during treatment: a GIM (Gruppo Italiano Mammella) survey

Author

Bonotto, M., primary, Basile, D., additional, Gerratana, L., additional, Pelizzari, G., additional, Bartoletti, M., additional, Vitale, M.G., additional, Fanotto, V., additional, Lisanti, C., additional, Bozza, C., additional, Cinausero, M., additional, Andreetta, C., additional, Russo, S., additional, Mansutti, M., additional, Minisini, A.M., additional, Merlini, L., additional, De Laurentiis, M., additional, Montemurro, F., additional, Fasola, G., additional, Del Mastro, L., additional, and Puglisi, F., additional

Published
2017
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22. Final results from CAMEO-PRO study: complementary and alternative medicine in oncology. physicians inform oncological patients

Author

Bozza, C., primary, Gerratana, L., additional, Basile, D., additional, De Carlo, E., additional, Cortiula, F., additional, Pella, N., additional, Vitale, M.G., additional, Bartoletti, M., additional, Russo, S., additional, Bonotto, M., additional, Cinausero, M., additional, Fanotto, V., additional, Pelizzari, G., additional, Minisini, A.M., additional, Andreetta, C., additional, Mansutti, M., additional, Iacono, D., additional, Sottile, R., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2017
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23. Strategy of monitoring metastatic breast cancer (M-MBC) in clinical practice: more or less intensive?

Author

Vitale, M.G., primary, Bonotto, M., additional, Gerratana, L., additional, Basile, D., additional, Bartoletti, M., additional, Pelizzari, G., additional, Fanotto, V., additional, Lisanti, C., additional, Bozza, C., additional, Cinausero, M., additional, Iacono, D., additional, Poletto, E., additional, Barban, S., additional, Mansutti, I., additional, Minisini, A.M., additional, Russo, S., additional, Andreetta, C., additional, Mansutti, M., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2017
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24. Is chemotherapy worthwhile in patients with high-risk, lymph node negative, FIGO stage 1, endometrial cancer?

Author

Fontanella, C., primary, Barcellini, A., additional, Vitale, M.G., additional, Lepori, S., additional, Maltese, G., additional, Tripodi, E., additional, Cerrotta, A., additional, Martinelli, F., additional, Andreetta, C., additional, Bogani, G., additional, Ditto, A., additional, Signorelli, M., additional, Scaffa, C., additional, Sacco, C., additional, Raspagliesi, F., additional, and Lorusso, D., additional

Published
2017
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25. Is chemotherapy worthwhile in patients with FIGO stage 1B, lymph nodes negative, grade 3 endometrial cancer?

Author

Fontanella, C., primary, Lepori, S., additional, Barcellini, A., additional, Maltese, G., additional, Andreetta, C., additional, Tripodi, E., additional, Martinelli, F., additional, Cerrotta, A., additional, Bogani, G., additional, Ditto, A., additional, Signorelli, M., additional, Scaffa, C., additional, Sacco, C., additional, Raspagliesi, F., additional, and Lorusso, D., additional

Published
2017
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27. Treatment strategies in patients with Metastatic Breast Cancer: real-world practice in the United Kingdom (UK) and Italy

Author

Ferrari, L., primary, Gerratana, L., additional, Jove, M., additional, Bonotto, M., additional, Cinausero, M., additional, Iacono, D., additional, Fontanella, C., additional, Bozza, C., additional, Fanotto, V., additional, Basile, D., additional, Pelizzari, G., additional, Vitale, M.G., additional, Minisini, A., additional, Mansutti, M., additional, Russo, S., additional, Andreetta, C., additional, Fasola, G., additional, Puglisi, F., additional, and Twelves, C., additional

Published
2016
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28. Last-line treatment of luminal metastatic breast cancer: which factors influence the therapeutic choice?

Author

Cinausero, M., primary, Gerratana, L., additional, Bonotto, M., additional, Iacono, D., additional, Bozza, C., additional, Basile, D., additional, Pelizzari, G., additional, Vitale, M.G., additional, Fontanella, C., additional, Fanotto, V., additional, Andreetta, C., additional, Minisini, A.M., additional, Moroso, S., additional, Poletto, E., additional, Russo, S., additional, Mansutti, M., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2016
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31. Abstract P2-08-06: Usefulness of the pre-treatment neutrophil-to-lymphocyte ratio in predicting first-line progression free-survival in triple-negative breast cancer patients

Author

Fontanella, C, primary, Fanotto, V, additional, Gerratana, L, additional, Bonotto, M, additional, Cinausero, M, additional, Bozza, C, additional, Iacono, D, additional, Russo, S, additional, Andreetta, C, additional, Minisini, AM, additional, Moroso, S, additional, Mansutti, M, additional, Fasola, G, additional, and Puglisi, F, additional

Published
2016
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32. Luminal-like metastatic breast cancer: which is the room of endocrine maintenance therapy after first line chemotherapy?

Author

Moroso, S., primary, Bonotto, M., additional, Gerratana, L., additional, Arpino, G., additional, De Angelis, C., additional, Iacono, D., additional, Cinausero, M., additional, Milano, M., additional, Gargiulo, P., additional, Fontanella, C., additional, Bozza, C., additional, Fanotto, V., additional, De Carlo, E., additional, Guardascione, M., additional, Russo, S., additional, Andreetta, C., additional, Minisini, A.M., additional, Mansutti, M., additional, Fasola, G., additional, De Placido, S., additional, and Puglisi, F., additional

Published
2015
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33. Risk of unplanned presentations and hospital admission of metastatic breast cancer outpatients

Author

Fontanella, C., primary, Fanotto, V., additional, De Carlo, E., additional, Iacono, D., additional, Bozza, C., additional, Bonotto, M., additional, Cinausero, M., additional, Gerratana, L., additional, Guardascione, M., additional, Rihawi, K., additional, Russo, S., additional, Andreetta, C., additional, Minisini, A.M., additional, Moroso, S., additional, Mansutti, M., additional, Sottile, R., additional, Aprile, G., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2015
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34. Last-line treatment of advanced breast cancer: outcome measures and prognostic factors

Author

Cinausero, M., primary, Gerratana, L., additional, Iacono, D., additional, Bonotto, M., additional, Bozza, C., additional, Bolzonello, S., additional, Fanotto, V., additional, Poletto, E., additional, Fontanella, C., additional, Guardascione, M., additional, Minisini, A.M., additional, Russo, S., additional, Andreetta, C., additional, Moroso, S., additional, Mansutti, M., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2015
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35. Unplanned hospital admission of early breast cancer outpatients treated with adjuvant chemotherapy

Author

Bozza, C., primary, Fontanella, C., additional, Fanotto, V., additional, De Carlo, E., additional, Iacono, D., additional, Bonotto, M., additional, Cinausero, M., additional, Gerratana, L., additional, Guardascione, M., additional, Rihawi, K., additional, Russo, S., additional, Andreetta, C., additional, Minisini, A.M., additional, Moroso, S., additional, Mansutti, M., additional, Aprile, G., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2015
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37. 1860 Last-line treatment of advanced breast cancer: Which clinical characteristics maypredict the outcome?

Author

Cinausero, M., primary, Gerratana, L., additional, Iacono, D., additional, Bonotto, M., additional, Bozza, C., additional, Bolzonello, S., additional, Fanotto, V., additional, Poletto, E., additional, Fontanella, C., additional, Guardascione, M., additional, Minisini, A.M., additional, Russo, S., additional, Andreetta, C., additional, Moroso, S., additional, Sottile, R., additional, Mansutti, M., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2015
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39. 1227 Risk of unplanned presentations and hospital admission of breast cancer outpatients

Author

Fontanella, C., primary, Fanotto, V., additional, De Carlo, E., additional, Iacono, D., additional, Bozza, C., additional, Bonotto, M., additional, Cinausero, M., additional, Gerratana, L., additional, Guardascione, M., additional, Russo, S., additional, Andreetta, C., additional, Moroso, S., additional, Minisini, A.M., additional, Mansutti, M., additional, Aprile, G., additional, Fasola, G., additional, and Puglisi, F., additional

Published
2015
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45. Operable Breast Cancer: preliminary results of a phase II, double blind, placebo controlled, randomized trial of preoperative chemotherapy +/- gefitinib with biomarkers evaluation

Author

Guarneri, V., Frassoldati, A., Ficarra, G., Giovannelli, S., Borghi, F., Puglisi, F., Mansutti, M., Andreetta, C., Banna, G., Masci, G., Santoro, A., Boni, C., Giancarlo Bisagni, Michelotti, A., Crispino, S., and Conte, Pf

Subjects
breast cancer, EGFR, Chemotherapy, Gefitinib, neoadjuvant therapy, MAPK
Published
2005

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