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Methimazole or thiamazole is the most commonly used remedy in the medical management of hyperthyroidism, an endocrine disorder with growing prevalence, particularly in geriatric feline patients. Unfortunately, veterinarians have little, or most often, no access to the transdermal conditionings. The novelty of this research is that very few. transdermal formulations that include methimazole are studied yet in the veterinary field, and most often, the efficacy of methimazole is studied using pluronic lecithin organogel or lipophilic formulations as a vehicle in healthy or hyperthyroid cats. In this aim, our study followed a formulation of topical methimazole that includes a human base cream as a vehicle. Five healthy cats were included in this study and received 0.1 mL cream containing 10 mg methimazole over 15 days. The ointment was applied to the hairless portions of the inner pinna and: the body weight, hematological, biochemical parameters, the adverse effects, and total thyroxin serum concentration were monitored on day 0 and day 16. Topical reactions were observed after treatment, on day 14, after 15 days of topical methimazole application. Thyroxin serum concentration was significantly lower compared to the concentrations seen on day 0, allowing us to conclude that, the incorporation of methimazole in a dermatological cream base induces, at the same dose of 10 mg × 0.1 mL-1, a significant change in total thyroxin levels, changes comparable to those acquired by other authors using PLO or lipophilic gel.

The cardiovascular and renal system suffer a series of hemodynamic changes under the action of excess thyroid hormone. The pathogenity of this excess can be reduced once the primary disease, hyperthyroidism or hypothyroidism, is under treatment. When treatment is not efficiently administered, the secondary disorders will become permanent and the quality and expectancy of life will be reduce. This is why the effects and the consequences of the thyroid hormones needs to be fully understood.

By using several samples collected from different farms distances it can be determined the degree of farms pollution and their effects on ecosystems. In order to avoid any error the soil samples were tested in comparison with a control soil sample, used as a reference, considered animal waste pollution free. The registration of survival rate for each testing recipient and for each soil along five repeats was a critical control point of testing. The 11 identified soil types were tested in comparison with a clean reference soil, by using 275 test earthworms and 55 control earthworms. According to normality Kolmogorov- Smirnov test the mortality was analyzed and results were significant (p=0.046).

The thyroid gland is located in the cervical fascia were it is divided in two lateral lobes, right and left, disposed on both sides of the trachea, and unlike other vertebrates, the cat does not have an isthmus that connects the two lobes. The main products of secretion of the thyroid gland are represented by thyroxine [T4] and 3,5,3 'triiodothyronine [T3]. To these are added other hormones resulted from the deiodination of the principle hormones. This process is catalized by the D1, D2 and D3 deiodinase resulting 3,3,5' triiodothyronine [rT3], 3,5-T2, 3,3’-T2 or 3’,5’-T2 which by further deiodination will form 3-3'-T1 and T1. To reach this deiodination must be followed certain steps in the hormon synthesis transport path, and it is important the present of the carrier protein. Once inside the tissue, the concentration of each hormone will vary depending on the binding site and the metabolic processes that will be followed.

inând cont de etiologia multifactorială a acestei endocrinopatii, confirmarea diagnosticului de hipertiroidism a întâmpinat numeroase dificultăti de-alungul anilor nu numai datorită necesitătii unor cunostiinte medicale cât si a lipsei posibilitătii de a realizare diferite examene de laborator mai mult sau mai putin accesibile. Astfel că în prezent metodele cele mai frecvent utilizate si accesibile sunt dozarea hormonilor tiroidieni totali sau liberi, testul de supresie cu triiodtironină, iar una dintre metodele ce necesită aparatură specială însă nu este accesibilă܈i în tara noastră este scintigrafia

Currently, the feline hyperthyroidism possesses three types of treatment that includes medication, surgery and radioactive therapie. The success of these therapies consists in obtaining favorable results, by inhibiting thyroid hormone secretion, reducing clinical signs, improving the live's quality and by absence of side effects of administered medication. One of these three therapies that fulfill these conditions and considered ideal for clinicians is the radiation therapy. Choosing this therapy depends not only on the availability of radioiodine licensed clinics or the presence of a skilled surgeon but also on the patient's clinical condition, especially when a cardiovascular or renal disease is present in this review paper.