10,969 results on '"Andreasson AN"'
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2. Canonical heights, periods and the Hurwitz zeta function
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Andreasson, Rolf and Berman, Robert J.
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Mathematics - Number Theory ,Mathematics - Algebraic Geometry ,Mathematics - Differential Geometry - Abstract
Let (X,D) be a projective log pair over the ring of integers of a number field such that the log canonical line bundle K_(X,D) or its dual -K_(X,D) is relatively ample. We introduce a canonical height of K_(X,D) (and -K(X,D)) which is finite precisely when the complexifications of K_(X,D) (and -K(X,D)) are K-semistable. When the complexifications are K-polystable, the canonical height is the height of K_(X,D) (and -K(X,D)) wrt any volume-normalized K\"ahler-Einstein metric on the complexifications of K_(X,D) (and -K(X,D)) The canonical height is shown to have a number of useful variational properties. Moreover, it may be expressed as a limit of periods on the N-fold products of the complexifications of X, as N tends to infinity. In particular, using this limit formula, the canonical height for the arithmetic log surfaces (P_1,D) over the integers, where D has at most three components, is computed explicitly in terms of the Hurwitz zeta function and its derivative at s=-1. Combining this explicit formula with previous height formulas for quaternionic Shimura curves yields a procedure for extracting information about the canonical integral models of some Shimura curves, such as wild ramification. Furthermore, explicit formulas for the canonical height of twisted Fermat curves are obtained, implying explicit Parshin type bounds for the Arakelov metric., Comment: 61 pages
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- 2024
3. Learning the Approach During the Short-loading Cycle Using Reinforcement Learning
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Borngrund, Carl, Bodin, Ulf, Andreasson, Henrik, and Sandin, Fredrik
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Computer Science - Robotics - Abstract
The short-loading cycle is a repetitive task performed in high quantities, making it a great alternative for automation. In the short-loading cycle, an expert operator navigates towards a pile, fills the bucket with material, navigates to a dump truck, and dumps the material into the tipping body. The operator has to balance the productivity goal while minimising the fuel usage, to maximise the overall efficiency of the cycle. In addition, difficult interactions, such as the tyre-to-surface interaction further complicate the cycle. These types of hard-to-model interactions that can be difficult to address with rule-based systems, together with the efficiency requirements, motivate us to examine the potential of data-driven approaches. In this paper, the possibility of teaching an agent through reinforcement learning to approach a dump truck's tipping body and get in position to dump material in the tipping body is examined. The agent is trained in a 3D simulated environment to perform a simplified navigation task. The trained agent is directly transferred to a real vehicle, to perform the same task, with no additional training. The results indicate that the agent can successfully learn to navigate towards the dump truck with a limited amount of control signals in simulation and when transferred to a real vehicle, exhibits the correct behaviour.
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- 2024
4. Towards introspective loop closure in 4D radar SLAM
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Hilger, Maximilian, Kubelka, Vladimír, Adolfsson, Daniel, Andreasson, Henrik, and Lilienthal, Achim J.
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Computer Science - Robotics - Abstract
Imaging radar is an emerging sensor modality in the context of Localization and Mapping (SLAM), especially suitable for vision-obstructed environments. This article investigates the use of 4D imaging radars for SLAM and analyzes the challenges in robust loop closure. Previous work indicates that 4D radars, together with inertial measurements, offer ample information for accurate odometry estimation. However, the low field of view, limited resolution, and sparse and noisy measurements render loop closure a significantly more challenging problem. Our work builds on the previous work - TBV SLAM - which was proposed for robust loop closure with 360$^\circ$ spinning radars. This article highlights and addresses challenges inherited from a directional 4D radar, such as sparsity, noise, and reduced field of view, and discusses why the common definition of a loop closure is unsuitable. By combining multiple quality measures for accurate loop closure detection adapted to 4D radar data, significant results in trajectory estimation are achieved; the absolute trajectory error is as low as 0.46 m over a distance of 1.8 km, with consistent operation over multiple environments., Comment: Submitted to the workshop "Radar in Robotics: Resilience from Signal to Navigation" at ICRA 2024
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- 2024
5. Regularity of the solution to a real Monge--Amp\`ere equation on the boundary of a simplex
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Andreasson, Rolf, Hultgren, Jakob, Jonsson, Mattias, Mazzon, Enrica, and McCleerey, Nicholas
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Mathematics - Analysis of PDEs ,Mathematics - Differential Geometry ,35J96, 53A15 (primary), 14J32, 14J33, 14T90, 32Q25 (secondary) - Abstract
Motivated by conjectures in Mirror Symmetry, we continue the study of the real Monge--Amp\`ere operator on the boundary of a simplex. This can be formulated in terms of optimal transport, and we consider, more generally, the problem of optimal transport between symmetric probability measures on the boundary of a simplex and of the dual simplex. For suitably regular measures, we obtain regularity properties of the transport map, and of its convex potential. To do so, we exploit boundary regularity results for optimal transport maps by Caffarelli, together with the symmetries of the simplex., Comment: 13 pages
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- 2024
6. Existence of a minimizer to the particle number-Casimir functional for the Einstein-Vlasov system
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Andréasson, Håkan and Kunze, Markus
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Mathematics - Analysis of PDEs ,General Relativity and Quantum Cosmology ,Mathematical Physics - Abstract
In 2001 Wolansky \cite{Wol} introduced a particle number-Casimir functional for the Einstein-Vlasov system. Two open questions are associated with this functional. First, a meaningful variational problem should be formulated and the existence of a minimizer to this problem should be established. The second issue is to show that a minimizer, for some choice of the parameters, is a static solution of the Einstein-Vlasov system. In the present work we solve the first problem by proving the existence of a minimizer to the particle number-Casimir functional. On the technical side, it is a main achievement that we are able to bypass the non-compactness of minimizing sequences by new arguments in both $v$-space and $x$-space, which might have several further applications. We note that such compactness results for the Einstein-Vlasov system have been absent in the literature, whereas similar results have been known in the Newtonian case. We also provide arguments which give strong support that minimizers corresponding to small masses are static solutions of the Einstein-Vlasov system. Furthermore, our analysis leads us to propose a new stability criterion for static solutions: We conjecture that a static solution for which the Casimir-binding energy is positive is stable for mass-preserving perturbations., Comment: 51 pages
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- 2024
7. Cybersecurity work at Swedish administrative authorities: taking action or waiting for approval
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Andreasson, Annika, Artman, Henrik, Brynielsson, Joel, and Franke, Ulrik
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- 2024
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8. Sharp bounds on the height of K-semistable Fano varieties II, the log case
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Andreasson, Rolf and Berman, Robert J.
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Mathematics - Algebraic Geometry ,Mathematics - Differential Geometry ,Mathematics - Number Theory ,14G40 (Primary), 32Q20, 53C25 (Secondary) - Abstract
In our previous work we conjectured - inspired by an algebro-geometric result of Fujita - that the height of an arithmetic Fano variety X of relative dimension $n$ is maximal when X is the projective space $\mathbb{P}^n_{\mathbb{Z}}$ over the integers, endowed with the Fubini-Study metric, if the corresponding complex Fano variety is K-semistable. In this work the conjecture is settled for diagonal hypersurfaces in $\mathbb{P}^{n+1}_{\mathbb{Z}}$. The proof is based on a logarithmic extension of our previous conjecture, of independent interest, which is established for toric log Fano varieties of relative dimension at most three, hyperplane arrangements on $\mathbb{P}^n_{\mathbb{Z}}$, as well as for general arithmetic orbifold Fano surfaces., Comment: 28 pages. Main changes in version 2: Included Lemma 4.3. In Thm 1.5 we now assume that the divisor has at most three irreducible components (which is automatic in the orbifold case). This assumption is needed in Lemma 6.2
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- 2023
9. TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models
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Wilson, Edward N., Wang, Congcong, Swarovski, Michelle S., Zera, Kristy A., Ennerfelt, Hannah E., Wang, Qian, Chaney, Aisling, Gauba, Esha, Ramos Benitez, Javier A., Le Guen, Yann, Minhas, Paras S., Panchal, Maharshi, Tan, Yuting J., Blacher, Eran, A. Iweka, Chinyere, Cropper, Haley, Jain, Poorva, Liu, Qingkun, Mehta, Swapnil S., Zuckerman, Abigail J., Xin, Matthew, Umans, Jacob, Huang, Jolie, Durairaj, Aarooran S., Serrano, Geidy E., Beach, Thomas G., Greicius, Michael D., James, Michelle L., Buckwalter, Marion S., McReynolds, Melanie R., Rabinowitz, Joshua D., and Andreasson, Katrin I.
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- 2024
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10. Stationary solutions of the axially symmetric Einstein-Vlasov system: present status and open problems
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Ames, E. and Andréasson, H.
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General Relativity and Quantum Cosmology - Abstract
The purpose of this work is to review the status about stationary solutions of the axially symmetric Einstein-Vlasov system with a focus on open problems of both analytical and numerical nature. For the latter we emphasize that the code used to construct stationary solutions in \cite{Ames2016,Ames2019} is open source, see \cite{Ames2023joss}. In the analytical setting the open problems include establishing methods for proving existence of axisymmetric stationary solutions which are far from spherically symmetric, both in the general case and for certain special classes of solutions pointed out in the text. In the numerical setting there are intriguing properties of highly relativistic solutions that demand further attention, such as whether a sequence of such stationary solutions can approach a Kerr black hole, or if they necessarily approach the thin ring limit reminiscent of cosmic strings. The question of whether stationary solutions include states with thin-disk like morphologies as seen in many galaxies is also open. Finally, there are opportunities to extend this research to new settings such as the case of massless particles and coupled black hole-matter systems. We believe that some of the open problems highlighted here are of central importance for the understanding of nature., Comment: 24 pages, 3 figures
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- 2023
11. Proof of the Einstein quadrupole formula for solutions of the Einstein-Vlasov system close to Minkowski spacetime
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Amorim, Érik, Andréasson, Håkan, and Kunze, Markus
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General Relativity and Quantum Cosmology - Abstract
We rigorously derive the quadrupole formula within the context of the Einstein-Vlasov system. The main contribution of this work is an estimate of the remainder terms, derived from well-defined assumptions, with explicitly stated error terms that depend on the solution's boundedness and decay properties, and the distance to the source. The assumptions are linked to established properties of global solutions of the Einstein-Vlasov system as in \cite{LT}. Prior derivations of the quadrupole formula have relied on post-Newtonian analysis and lacked comparisons with global solution properties. The importance of the no-incoming-radiation condition is emphasized underscoring the need for solutions satisfying this condition. This work thus addresses the limitations of existing results and provides motivation for further research on global solution properties of the Einstein-Vlasov system., Comment: 92 pages. To appear in Dissertationes Mathematicae
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- 2023
12. How-to Augmented Lagrangian on Factor Graphs
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Bazzana, Barbara, Andreasson, Henrik, and Grisetti, Giorgio
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Computer Science - Robotics - Abstract
Factor graphs are a very powerful graphical representation, used to model many problems in robotics. They are widely spread in the areas of Simultaneous Localization and Mapping (SLAM), computer vision, and localization. In this paper we describe an approach to fill the gap with other areas, such as optimal control, by presenting an extension of Factor Graph Solvers to constrained optimization. The core idea of our method is to encapsulate the Augmented Lagrangian (AL) method in factors of the graph that can be integrated straightforwardly in existing factor graph solvers. We show the generality of our approach by addressing three applications, arising from different areas: pose estimation, rotation synchronization and Model Predictive Control (MPC) of a pseudo-omnidirectional platform. We implemented our approach using C++ and ROS. Besides the generality of the approach, application results show that we can favorably compare against domain specific approaches., Comment: This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible
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- 2023
13. Organ aging signatures in the plasma proteome track health and disease.
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Oh, Hamilton, Rutledge, Jarod, Nachun, Daniel, Pálovics, Róbert, Abiose, Olamide, Moran-Losada, Patricia, Channappa, Divya, Urey, Deniz, Kim, Kate, Sung, Yun, Wang, Lihua, Timsina, Jigyasha, Western, Dan, Liu, Menghan, Kohlfeld, Pat, Budde, John, Wilson, Edward, Guen, Yann, Maurer, Taylor, Haney, Michael, He, Zihuai, Greicius, Michael, Andreasson, Katrin, Sathyan, Sanish, Weiss, Erica, Milman, Sofiya, Barzilai, Nir, Cruchaga, Carlos, Wagner, Anthony, Mormino, Elizabeth, Lehallier, Benoit, Henderson, Victor, Longo, Frank, Montgomery, Stephen, Wyss-Coray, Tony, and Yang, Andrew
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Adult ,Animals ,Humans ,Alzheimer Disease ,Proteome ,Aging ,Brain ,Cognitive Dysfunction ,Biomarkers - Abstract
Animal studies show aging varies between individuals as well as between organs within an individual1-4, but whether this is true in humans and its effect on age-related diseases is unknown. We utilized levels of human blood plasma proteins originating from specific organs to measure organ-specific aging differences in living individuals. Using machine learning models, we analysed aging in 11 major organs and estimated organ age reproducibly in five independent cohorts encompassing 5,676 adults across the human lifespan. We discovered nearly 20% of the population show strongly accelerated age in one organ and 1.7% are multi-organ agers. Accelerated organ aging confers 20-50% higher mortality risk, and organ-specific diseases relate to faster aging of those organs. We find individuals with accelerated heart aging have a 250% increased heart failure risk and accelerated brain and vascular aging predict Alzheimers disease (AD) progression independently from and as strongly as plasma pTau-181 (ref. 5), the current best blood-based biomarker for AD. Our models link vascular calcification, extracellular matrix alterations and synaptic protein shedding to early cognitive decline. We introduce a simple and interpretable method to study organ aging using plasma proteomics data, predicting diseases and aging effects.
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- 2023
14. Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases
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Tong Gong, Ralf Kuja-Halkola, Arvid Harder, Cecilia Lundholm, Awad I. Smew, Kelli Lehto, Anna Andreasson, Yi Lu, Nicholas J. Talley, Joëlle A. Pasman, Catarina Almqvist, and Bronwyn K. Brew
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Biology (General) ,QH301-705.5 - Abstract
Abstract The aim is to investigate the evidence for shared genetic architecture between each of asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD). Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 46,582) and reveal a modest genetic correlation between GERD and asthma of 0.18 and bidirectional PRS and phenotypic associations ranging between OR 1.09-1.14 and no correlations for eczema and allergic rhinitis. Linkage disequilibrium score regression is applied to summary statistics of recently published GERD and asthma/allergic disease genome wide association studies and reveals a genetic correlation of 0.48 for asthma and GERD, and Genomic SEM supports a single latent factor. A gene-/gene-set analysis using MAGMA reveals six pleiotropic genes (two at 12q13.2) associated with asthma and GERD. This study provides evidence that there is a common genetic architecture unique to asthma and GERD that may explain comorbidity and requires further investigation.
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- 2024
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15. Schooling in the Racist Badlands: Health Team Professionals' Understanding of the Problem of Racist Opinions and Practices among Students
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Christer Mattsson, Thomas Johansson, and Jesper Andreasson
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This study aimed to analyse how school health team professionals in geographical areas with a long tradition of neo-Nazi activism discursively conceptualise the problem of racism. The participants do not consider racism or neo-Nazi mobilisation to be a central problem at their schools. At the same time, they cited several examples of obvious expressions of neo-Nazi convictions among students. This discrepancy is explained in different capacities. Firstly, as the students are understood to have a mill-town mentality, certain behaviours are expected and excused. Secondly, to be seen as a problem, racist expression is also expected to be visual. A third factor is that the problem is individualised, focusing on one incident at a time.
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- 2024
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16. J-domain proteins : From molecular mechanisms to diseases
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Marszalek, Jaroslaw, De Los Rios, Paolo, Cyr, Douglas, Mayer, Matthias P., Adupa, Vasista, Andréasson, Claes, Blatch, Gregory L., Braun, Janice E.A., Brodsky, Jeffrey L., Bukau, Bernd, Chapple, J. Paul, Conz, Charlotte, Dementin, Sébastien, Genevaux, Pierre, Genest, Olivier, Goloubinoff, Pierre, Gestwicki, Jason, Hammond, Colin M., Hines, Justin K., Ishikawa, Koji, Joachimiak, Lukasz A., Kirstein, Janine, Liberek, Krzysztof, Mokranjac, Dejana, Nillegoda, Nadinath, Ramos, Carlos H.I., Rebeaud, Mathieu, Ron, David, Rospert, Sabine, Sahi, Chandan, Shalgi, Reut, Tomiczek, Bartlomiej, Ushioda, Ryo, Ustyantseva, Elizaveta, Ye, Yihong, Zylicz, Maciej, and Kampinga, Harm H.
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- 2024
17. Precariousness, Sport Participation and Hope Among Young People After Rejections in the Swedish Asylum Process
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ELSRUD, TORUN, LALANDER, PHILIP, ANDREASSON, JESPER, and HERZ, MARCUS
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- 2024
18. On the Hoop conjecture and the weak cosmic censorship conjecture for the axisymmetric Einstein-Vlasov system
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Ames, E., Andréasson, H., and Rinne, O.
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General Relativity and Quantum Cosmology - Abstract
We consider gravitational collapse for the axially symmetric Einstein-Vlasov system. We investigate the weak cosmic censorship conjecture in the case of highly prolate initial data and we investigate the ``only if" part of the Hoop conjecture. Shapiro and Teukolsky initiated a similar study in 1991 \cite{Shapiro1991} where they found support that the weak cosmic censorship conjecture was violated for sufficiently prolate spheroidal initial data. More recently, independent studies of this problem have been carried out by Yoo, Harada and Okawa \cite{Yoo2017} and by East \cite{East2019}. A common feature in these works is that the initial data are dust-like. Dust can be considered as a \textit{singular} case of matter described by the Einstein-Vlasov system. The original motivation by Shapiro and Teukolsky to study this problem is based on the Lin-Mestel-Shu instability for gravitational collapse of uniform spheroids in the case of dust in Newtonian gravity. We argue that the Lin-Mestel-Shu solution is not relevant for studying the weak cosmic censorship of the Einstein-Vlasov system and we argue that dust-like initial data is also not relevant. To investigate collapse of highly prolate spheroidal configurations for the Einstein-Vlasov system is nevertheless interesting in view of the Hoop conjecture. By choosing highly prolate initial data the weak cosmic censorship conjecture is seriously tested. We carry out such a study for initial data which are not dust-like. We find formation of an apparent horizon in all cases we consider, which provides support for the weak cosmic censorship conjecture. In our tests of the Hoop conjecture we compute the polar circumference $\mathcal{C}_{H,p}$ at the time when the apparent horizon forms and find that it is less than 12% above $4\pi M$, where $M$ is the irreducible mass of the apparent horizon, which agrees with the spirit of the Hoop conjecture., Comment: 18 pages, 7 figures
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- 2023
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19. Partners Care, Couplehood, and Intimate Life
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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20. Coping Strategies and the Emotionology of Masculinity
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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21. Narratives of Prostate Cancer: The Social Triad
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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22. Methodology and Method
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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23. Conclusion: Sexual Health and Ageing Prostate Cancer Masculinities
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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24. Men and Their Health
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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25. Leaking Bodies, Sexual Health, and Masculinity
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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26. The Care Apparatus and Healthcare Professionals at Work
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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27. The Cultural History of the Prostate
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Andreasson, Jesper, Johansson, Thomas, Andreasson, Jesper, and Johansson, Thomas
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- 2024
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28. Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases
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Gong, Tong, Kuja-Halkola, Ralf, Harder, Arvid, Lundholm, Cecilia, Smew, Awad I., Lehto, Kelli, Andreasson, Anna, Lu, Yi, Talley, Nicholas J., Pasman, Joëlle A., Almqvist, Catarina, and Brew, Bronwyn K.
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- 2024
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29. Enhanced stress resilience in potato by deletion of Parakletos
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Zahid, Muhammad Awais, Kieu, Nam Phuong, Carlsen, Frida Meijer, Lenman, Marit, Konakalla, Naga Charan, Yang, Huanjie, Jyakhwa, Sunmoon, Mravec, Jozef, Vetukuri, Ramesh, Petersen, Bent Larsen, Resjö, Svante, and Andreasson, Erik
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- 2024
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30. Bright continuously tunable vacuum ultraviolet source for ultrafast spectroscopy
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Jurkovičová, Lucie, Ben Ltaief, Ltaief, Hult Roos, Andreas, Hort, Ondřej, Finke, Ondřej, Albrecht, Martin, Hoque, Ziaul, Klimešová, Eva, Sundaralingam, Akgash, Antipenkov, Roman, Grenfell, Annika, Špaček, Alexandr, Szuba, Wojciech, Krikunova, Maria, Mudrich, Marcel, Nejdl, Jaroslav, and Andreasson, Jakob
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- 2024
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31. Experimental and theoretical study of stress relaxation in high-density polyethylene
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Kroon, Martin, Görtz, Jakob, Islam, Shafiqul, Andreasson, Eskil, Petersson, Viktor, and Jutemar, Elin Persson
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- 2024
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32. Prevalence of Histological Gastritis in a Community Population and Association with Epigastric Pain
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Zuzek, Rachael, Potter, Michael, Talley, Nicholas J., Agréus, L., Andreasson, A., Veits, L., Vieth, M., and Walker, M. M.
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- 2024
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33. Long-lasting XUV activation of helium nanodroplets for avalanche ionization
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Medina, C., Lægdsmand, A. Ø., Ltaief, L. Ben, Hoque, Z., Roos, A. H., Jurkovič, M., Hort, O., Finke, O., Albrecht, M., Nejdl, J., Stienkemeier, F., Andreasson, J., Klimešová, E., Krikunova, M., Heidenreich, A., and Mudrich, M.
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Physics - Atomic and Molecular Clusters - Abstract
We study the dynamics of avalanche ionization of pure helium nanodroplets activated by a weak extreme-ultraviolet (XUV) pulse and driven by an intense near-infrared (NIR) pulse. In addition to a transient enhancement of ignition of a nanoplasma at short delay times $\sim200$~fs, long-term activation of the nanodroplets lasting up to a few nanoseconds is observed. Molecular dynamics simulations suggest that the short-term activation is caused by the injection of seed electrons into the droplets by XUV photoemission. Long-term activation appears due to electrons remaining loosely bound to photoions which form stable `snowball' structures in the droplets. Thus, we show that XUV irradiation can induce long-lasting changes of the strong-field optical properties of nanoparticles, potentially opening new routes to controlling avalanche-ionization phenomena in nanostructures and condensed-phase systems.
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- 2023
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34. Solvability of Monge-Amp\`ere equations and tropical affine structures on reflexive polytopes
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Andreasson, Rolf and Hultgren, Jakob
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Mathematics - Differential Geometry ,14J32, 14J33, 32Q25, 35J96, 53A15 (primary) 14T90 (secondary) - Abstract
Given a reflexive polytope with a height function, we prove a necessary and sufficient condition for solvability of the associated Monge-Amp\`ere equation. When the polytope is Delzant, solvability of this equation implies the metric SYZ conjecture for the corresponding family of Calabi-Yau hypersurfaces. We show how the location of the singularities in the tropical affine structure is determined by the PDE in the spirit of a free boundary problem and give positive and negative examples, demonstrating subtle issues with both solvability and properties of the singular set. We also improve on existing results regarding the SYZ conjecture for the Fermat family by showing regularity of the limiting potential., Comment: 46 pages. Added an appendix pointing out a geometric consequence of the regularity result for the standard unit simplex and the unit cube
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- 2023
35. Enhanced stress resilience in potato by deletion of Parakletos
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Muhammad Awais Zahid, Nam Phuong Kieu, Frida Meijer Carlsen, Marit Lenman, Naga Charan Konakalla, Huanjie Yang, Sunmoon Jyakhwa, Jozef Mravec, Ramesh Vetukuri, Bent Larsen Petersen, Svante Resjö, and Erik Andreasson
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Science - Abstract
Abstract Continued climate change impose multiple stressors on crops, including pathogens, salt, and drought, severely impacting agricultural productivity. Innovative solutions are necessary to develop resilient crops. Here, using quantitative potato proteomics, we identify Parakletos, a thylakoid protein that contributes to disease susceptibility. We show that knockout or silencing of Parakletos enhances resistance to oomycete, fungi, bacteria, salt, and drought, whereas its overexpression reduces resistance. In response to biotic stimuli, Parakletos-overexpressing plants exhibit reduced amplitude of reactive oxygen species and Ca2+ signalling, and silencing Parakletos does the opposite. Parakletos homologues have been identified in all major crops. Consecutive years of field trials demonstrate that Parakletos deletion enhances resistance to Phytophthora infestans and increases yield. These findings demark a susceptibility gene, which can be exploited to enhance crop resilience towards abiotic and biotic stresses in a low-input agriculture.
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- 2024
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36. Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer's disease spectra
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Melanie J. Plastini, Carla Abdelnour, Christina B. Young, Edward N. Wilson, Marian Shahid‐Besanti, Jennifer Lamoureux, Katrin I. Andreasson, Geoffrey A. Kerchner, Thomas J. Montine, Victor W. Henderson, and Kathleen L. Poston
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective More than half of neurodegenerative disease patients have multiple pathologies at autopsy; however, most receive one diagnosis during life. We used the α‐synuclein seed amplification assay (αSyn‐SAA) and CSF biomarkers for amyloidosis and Alzheimer's disease (AD) neuropathological change (ADNC) to determine the frequency of co‐pathologies in participants clinically diagnosed with Lewy body (LB) disease or AD. Methods Using receiver operating characteristic analyses on retrospective CSF samples from 150 participants determined αSyn‐SAA accuracy, sensitivity, and specificity for identifying clinically defined LB disease and predicting future change in clinical diagnosis. CSF biomarkers helped determine the frequency of concomitant Lewy body pathology, ADNC, and/or amyloidosis in participants with LB disease and AD, across clinical spectra. Results Following a decade‐long follow‐up, the clinically or autopsy‐defined diagnosis changed for nine participants. αSyn‐SAA demonstrated improved accuracy (91.3%), sensitivity (89.3%), and specificity (93.3%) for identifying LB disease compared to all non‐LB disease, highlighting the limitations of clinical diagnosis alone. When examining biomarkers of co‐pathology, amyloidosis was present in 18%, 48%, and 71% (χ2(2) = 13.56, p = 0.001) and AD biomarkers were present in 0%, 8.7%, and 42.9% (χ2(2) = 18.44, p
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- 2024
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37. Bright continuously-tunable VUV source for ultrafast spectroscopy
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Jurkovičová, Lucie, Ltaief, Ltaief Ben, Roos, Andreas Hult, Hort, Ondřej, Finke, Ondřej, Albrecht, Martin, Hoque, Ziaul, Klimešová, Eva, Sundaralingam, Akgash, Antipenkov, Roman, Grenfell, Annika, Špaček, Alexandr, Szuba, Wojciech, Krikunova, Maria, Mudrich, Marcel, Nejdl, Jaroslav, and Andreasson, Jakob
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Physics - Atomic Physics ,Physics - Atomic and Molecular Clusters ,Physics - Optics - Abstract
Ultrafast electron dynamics drive phenomena such as photochemical reactions, catalysis, and light harvesting. To capture such dynamics in real-time, femtosecond to attosecond light sources are extensively used. However, an exact match between the excitation photon energy and a characteristic resonance is crucial. High-harmonic generation sources are exceptional in terms of pulse duration but limited in spectral tunability in the VUV range. Here, we present a monochromatic femtosecond source continuously tunable around 21 eV photon energy utilizing the second harmonic of an OPCPA laser system to drive high-harmonic generation. The unique tunability of the source is verified in an experiment probing the interatomic Coulombic decay in doped He nanodroplets across the He absorption bands. Moreover, we achieved intensities sufficient for driving non-linear processes using a tight focusing of the VUV beam. We demonstrated it on the observation of collective autoionization of multiply excited pure He nanodroplets., Comment: 12 pages, 5 figures, submitted to Nat. Commun
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- 2023
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38. TBV Radar SLAM -- trust but verify loop candidates
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Adolfsson, Daniel, Karlsson, Mattias, Kubelka, Vladimír, Magnusson, Martin, and Andreasson, Henrik
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Computer Science - Robotics - Abstract
Robust SLAM in large-scale environments requires fault resilience and awareness at multiple stages, from sensing and odometry estimation to loop closure. In this work, we present TBV (Trust But Verify) Radar SLAM, a method for radar SLAM that introspectively verifies loop closure candidates. TBV Radar SLAM achieves a high correct-loop-retrieval rate by combining multiple place-recognition techniques: tightly coupled place similarity and odometry uncertainty search, creating loop descriptors from origin-shifted scans, and delaying loop selection until after verification. Robustness to false constraints is achieved by carefully verifying and selecting the most likely ones from multiple loop constraints. Importantly, the verification and selection are carried out after registration when additional sources of loop evidence can easily be computed. We integrate our loop retrieval and verification method with a fault-resilient odometry pipeline within a pose graph framework. By evaluating on public benchmarks we found that TBV Radar SLAM achieves 65% lower error than the previous state of the art. We also show that it's generalizing across environments without needing to change any parameters., Comment: Accepted for RAL, to be presented at IROS 2023, Detroit. Code: https://github.com/dan11003/tbv_slam_public Submission video: https://youtu.be/t8HQtHAUHHc
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- 2023
39. Lidar-level localization with radar? The CFEAR approach to accurate, fast and robust large-scale radar odometry in diverse environments
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Adolfsson, Daniel, Magnusson, Martin, Alhashimi, Anas, Lilienthal, Achim J., and Andreasson, Henrik
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Computer Science - Robotics - Abstract
This paper presents an accurate, highly efficient, and learning-free method for large-scale odometry estimation using spinning radar, empirically found to generalize well across very diverse environments -- outdoors, from urban to woodland, and indoors in warehouses and mines - without changing parameters. Our method integrates motion compensation within a sweep with one-to-many scan registration that minimizes distances between nearby oriented surface points and mitigates outliers with a robust loss function. Extending our previous approach CFEAR, we present an in-depth investigation on a wider range of data sets, quantifying the importance of filtering, resolution, registration cost and loss functions, keyframe history, and motion compensation. We present a new solving strategy and configuration that overcomes previous issues with sparsity and bias, and improves our state-of-the-art by 38%, thus, surprisingly, outperforming radar SLAM and approaching lidar SLAM. The most accurate configuration achieves 1.09% error at 5Hz on the Oxford benchmark, and the fastest achieves 1.79% error at 160Hz., Comment: Published in Transactions on Robotics. Edited 2022-11-07: Updated affiliation and citation
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- 2022
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40. Robust Object Detection in Challenging Weather Conditions.
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Himanshu Gupta, Oleksandr Kotlyar, Henrik Andreasson, and Achim J. Lilienthal
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- 2024
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41. Zero Self-Harm app: a mobile phone application to reduce non-suicidal self-injury—study protocol for a randomized controlled trial
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Evelyn Guerrero, Kate Andreasson, Lene Larsen, Niels Buus, Jette Louise Skovgaard Larsen, Jesper Krogh, Rasmus Thastum, Lone Lindberg, Katrine Lindblad, Annette Erlangsen, and Merete Nordentoft
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Non-suicidal ,Self-injury ,Self-harm ,Randomized controlled trial ,Self-help ,Mobile phone application ,Medicine (General) ,R5-920 - Abstract
Abstract Background Non-suicidal self-injury (NSSI) is a growing healthcare problem. Individuals with NSSI have an increased risk of suicidality. Due to stigma, they may self-injure in secret, which means they might not seek help until events have escalated to include suicidal ideation or a mental disorder. Interventions delivered via mobile phone applications (apps) have been linked to reductions in self-injury. This protocol outlines a trial, which examines whether the Zero Self-Harm intervention, consisting of an app for people with NSSI, can reduce the number of NSSI episodes, suicide ideation, and depressive symptoms. Methods The trial will be conducted as a 6-month 2-arm, parallel-group, multicentre, pragmatic, randomized clinical superiority trial. The intervention group will receive the app and instructions on how to use it, while the control group will be allocated to a waitlist and allowed to download the app after 6 months. After inclusion, participants will be asked to complete questionnaires at baseline, 3 months, and 6 months. The primary outcome is the number of NSSI episodes during the preceding month, as measured at the 6 months follow-up with the Deliberate Self-Harm Inventory. A total of 280 participants, 140 in each arm, will be included. Discussion This trial will assess the effectiveness of the Zero Self-Harm intervention to reduce the number of NSSI episodes. If effective, the app will have the potential to support a large group of people with NSSI. Considering the stigma related to NSSI, the fact that the app may be used in private and anonymously might make it an appealing and acceptable option for support. The app was developed in collaboration with people with lived experiences related to current and/or previous NSSI. As a result of this, the app focuses on minimizing harm, rather than stopping NSSI. This might enhance its utilization. Trial registration ClinicalTrials.gov NCT04463654 . Registered on 7 June 2020.
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- 2024
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42. Software Architectures for Mobile Robots
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Andreasson, Henrik, Grisetti, Giorgio, Stoyanov, Todor, and Pretto, Alberto
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Computer Science - Robotics - Abstract
A software architecture defines the blueprints of a large computational system, and is thus a crucial part of the design and development effort. This task has been explored extensively in the context of mobile robots, resulting in a plethora of reference designs and implementations. As the software architecture defines the framework in which all components are implemented, it is naturally a very important aspect of a mobile robot system. In this chapter, we overview the requirements that the particular problem domain (a mobile robot system) imposes on the software framework. We discuss some of the current design solutions, provide a historical perspective on common frameworks, and outline directions for future development., Comment: This chapter appears in: Ang, M.H., Khatib, O., Siciliano, B. (eds) Encyclopedia of Robotics. Springer, Berlin, Heidelberg
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- 2022
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43. Sensors for Mobile Robots
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Andreasson, Henrik, Grisetti, Giorgio, Stoyanov, Todor, and Pretto, Alberto
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Computer Science - Robotics - Abstract
A sensor is a device that converts a physical parameter or an environmental characteristic (e.g., temperature, distance, speed, etc.) into a signal that can be digitally measured and processed to perform specific tasks. Mobile robots need sensors to measure properties of their environment, thus allowing for safe navigation, complex perception and corresponding actions, and effective interactions with other agents that populate it. Sensors used by mobile robots range from simple tactile sensors, such as bumpers, to complex vision-based sensors such as structured light RGB-D cameras. All of them provide a digital output (e.g., a string, a set of values, a matrix, etc.) that can be processed by the robot's computer. Such output is typically obtained by discretizing one or more analog electrical signals by using an Analog to Digital Converter (ADC) included in the sensor. In this chapter we present the most common sensors used in mobile robotics, providing an introduction to their taxonomy, basic features, and specifications. The description of the functionalities and the types of applications follows a bottom-up approach: the basic principles and components on which the sensors are based are presented before describing real-world sensors, which are generally based on multiple technologies and basic devices., Comment: This chapter appears in: Ang, M.H., Khatib, O., Siciliano, B. (eds) Encyclopedia of Robotics. Springer, Berlin, Heidelberg
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- 2022
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44. Femtosecond pump-probe absorption edge spectroscopy of cubic GaN
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Baron, Elias, Goldhahn, Rüdiger, Espinoza, Shirly, Zahradník, Martin, Rebarz, Mateusz, Andreasson, Jakob, Deppe, Michael, As, Donat J., and Feneberg, Martin
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Condensed Matter - Materials Science - Abstract
Time-dependent femtosecond pump-probe spectroscopic ellipsometry studies on zincblende gallium-nitride (zb-GaN) are performed and analyzed between 2.9-3.7eV. An ultra-fast change of the absorption onset (3.23eV for zb-GaN) is observed by investigating the imaginary part of the dielectric function. The 266nm (4.66eV) pump pulses induce a large free-carrier concentration up to $4\times 10^{20}$cm$^{-3}$, influencing the transition energy between conduction and valence bands due to many-body effects, like band filling and band gap renormalization, up to $\approx$500meV. Additionally, the absorption of the pump-beam creates a free-carrier profile within the 605nm zb-GaN layer. This leads to varying optical properties from sample surface to substrate, which are taken into account by grading analysis for an accurate description of the experimental data. A temporal resolution of 100fs allows in-depth investigations of occurring ultra-fast relaxation and recombination processes. We provide a quantitative description of the free-carrier concentration and absorption onset at the sample surface as a function of relaxation, recombination, and diffusion yielding a characteristic relaxation time of 0.19ps and a recombination time of 26.1ps.
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- 2022
45. Ultrafast collapse of molecular polaritons in photoswitch-nanoantennas at room temperature
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Kuttruff, Joel, Romanelli, Marco, Pedrueza-Villalmanzo, Esteban, Allerbeck, Jonas, Fregoni, Jacopo, Saavedra-Becerril, Valeria, Andréasson, Joakim, Brida, Daniele, Dmitriev, Alexandre, Corni, Stefano, and Maccaferri, Nicolò
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics - Abstract
Molecular polaritons are hybrid light-matter states that emerge when a molecular transition strongly interacts with photons in a resonator. At optical frequencies, this interaction unlocks a way to explore and control new chemical phenomena at the nanoscale. Achieving such a control at ultrafast timescales, however, is an outstanding challenge, as it requires a deep understanding of the dynamics of the collectively coupled molecular excitation and the nanoconfined electromagnetic fields. Here, we investigate the dynamics of collective polariton states, realized by coupling molecular photoswitches to optically anisotropic plasmonic nanoantennas. Pump-probe experiments reveal an ultrafast collapse of polaritons to a single-molecule transition triggered by femtosecond-pulse excitation at room-temperature. Through a synergistic combination of experiments and quantum mechanical modelling, we show that the response of the system is governed by intramolecular dynamics, occurring one order of magnitude faster with respect to the unperturbed excited molecule relaxation to the ground state.
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- 2022
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46. CorAl: Introspection for Robust Radar and Lidar Perception in Diverse Environments Using Differential Entropy
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Adolfsson, Daniel, Castellano-Quero, Manuel, Magnusson, Martin, Lilienthal, Achim J., and Andreasson, Henrik
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Computer Science - Robotics - Abstract
Robust perception is an essential component to enable long-term operation of mobile robots. It depends on failure resilience through reliable sensor data and preprocessing, as well as failure awareness through introspection, for example the ability to self-assess localization performance. This paper presents CorAl: a principled, intuitive, and generalizable method to measure the quality of alignment between pairs of point clouds, which learns to detect alignment errors in a self-supervised manner. CorAl compares the differential entropy in the point clouds separately with the entropy in their union to account for entropy inherent to the scene. By making use of dual entropy measurements, we obtain a quality metric that is highly sensitive to small alignment errors and still generalizes well to unseen environments. In this work, we extend our previous work on lidar-only CorAl to radar data by proposing a two-stage filtering technique that produces high-quality point clouds from noisy radar scans. Thus we target robust perception in two ways: by introducing a method that introspectively assesses alignment quality, and applying it to an inherently robust sensor modality. We show that our filtering technique combined with CorAl can be applied to the problem of alignment classification, and that it detects small alignment errors in urban settings with up to 98% accuracy, and with up to 96% if trained only in a different environment. Our lidar and radar experiments demonstrate that CorAl outperforms previous methods both on the ETH lidar benchmark, which includes several indoor and outdoor environments, and the large-scale Oxford and MulRan radar data sets for urban traffic scenarios The results also demonstrate that CorAl generalizes very well across substantially different environments without the need of retraining., Comment: Accepted for Robotics and Autonomous Systems, Selected papers from the 9th European Conference on Mobile Robots (ECMR 2021) https://www.sciencedirect.com/science/article/pii/S0921889022000768. arXiv admin note: text overlap with arXiv:2109.09820
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- 2022
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47. Sharp bounds on the height of K-semistable Fano varieties I, the toric case
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Andreasson, Rolf and Berman, Robert J.
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Mathematics - Algebraic Geometry ,Mathematics - Differential Geometry ,Mathematics - Number Theory ,14G40 (primary), 32Q20, 53C25, 11G50, 14J45 (secondary) - Abstract
Inspired by Fujita's algebro-geometric result that complex projective space has maximal degree among all K-semistable complex Fano varieties, we conjecture that the height of a K-semistable metrized arithmetic Fano variety X of relative dimension n is maximal when X is the projective space over the integers, endowed with the Fubini-Study metric. Our main result establishes the conjecture for the canonical integral model of a toric Fano variety when n is less than or equal to 6 (the extension to higher dimensions is conditioned on a conjectural "gap hypothesis" for the degree). Translated into toric K\"ahler geometry this result yields a sharp lower bound on a toric invariant introduced by Donaldson, defined as the minimum of the toric Mabuchi functional. We furthermore reformulate our conjecture as an optimal lower bound on Odaka's modular height. In any dimension n it is shown how to control the height of the canonical toric model X, with respect to the K\"ahler-Einstein metric, by the degree of X. In a sequel to this paper our height conjecture is established for any projective diagonal Fano hypersurface, by exploiting a more general logarithmic setup., Comment: 39 pages. v3: Changed title. Accepted for publication in Compositio Math
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- 2022
48. Effect of on-demand vs continuous prescription of proton pump inhibitors on symptom burden and quality of life: results of a real-world randomized controlled trial in primary care patients with gastroesophageal reflux disease
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Anna Andreasson, Lars Agréus, Nikolaos Mastellos, Grzegorz Bliźniuk, Dorota Waśko-Czopnik, Agapi Angelaki, Eirini Theodosaki, Christos Lionis, Karin Hek, Robert Verheij, Ellen Wright, Stevo Durbaba, Jean Muris, Piotr Bródka, Stanislaw Saganowski, Jean-Francois Ethiér, Vasa Curcin, and Brendan Delaney
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gastroesophageal reflux disease ,proton pump inhibitors ,continuous use ,on-demand use ,randomized controlled trial ,quality of life ,Medicine - Abstract
AbstractObjectives This study aimed to assess the impact of on-demand versus continuous prescribing of proton pump inhibitors (PPIs) on symptom burden and health-related quality of life in patients with gastroesophageal reflux disease (GERD) presenting to primary care.Methods Thirty-six primary care centres across Europe enrolled adult GERD patients from electronic health records. Participants were randomised to on-demand or continuous PPI prescriptions and were followed for 8 weeks. PPI intake, symptom burden, and quality of life were compared between the two groups using mixed-effect regression analyses. Spearman’s correlation was used to assess the association between changes in PPI dose and patient-reported outcomes.Results A total of 488 patients (median age 51 years, 58% women) completed the initial visit, with 360 attending the follow-up visit. There was no significant difference in PPI use between the continuous and on-demand prescription groups (b=.57, 95%CI:0.40-1.53), although PPI use increased in both groups (b = 1.33, 95%CI:0.65 − 2.01). Advice on prescribing strategy did not significantly affect patient-reported outcomes. Both symptom burden (Reflux Disease Questionnaire, b=-0.61, 95%CI:-0.73 − -0.49) and quality of life (12-item Short Form Survey physical score b = 3.31, 95%CI:2.17 − 4.45) improved from baseline to follow-up in both groups. Increased PPI intake correlated with reduced reflux symptoms (n = 347, ρ=-0.12, p = 0.02) and improved quality of life (n = 217, ρ = 0.16, p = 0.02).Conclusion In real-world settings, both continuous and on-demand PPI prescriptions resulted in similar increases in PPI consumption with no difference in treatment effects. Achieving an adequate PPI dose to alleviate reflux symptom burden improves quality of life in GERD patients. EudraCT number 2014-001314-25.
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- 2024
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49. FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis.
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Liu, Cong, Schönke, Milena, Spoorenberg, Borah, Lambooij, Joost, van der Zande, Hendrik, Zhou, Enchen, Tushuizen, Maarten, Andreasson, Anne-Christine, Park, Andrew, Oldham, Stephanie, Uhrbom, Martin, Ahlstedt, Ingela, Ikeda, Yasuhiro, Wallenius, Kristina, Peng, Xiao-Rong, Guigas, Bruno, Boon, Mariëtte, Wang, Yanan, and Rensen, Patrick
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fibroblast growth factor 21 ,immunology ,inflammation ,lipid/scar-associated macrophages ,liver-adipose tissue crosstalk ,medicine ,mouse ,steatohepatitis ,Mice ,Humans ,Animals ,Non-alcoholic Fatty Liver Disease ,Diabetes Mellitus ,Type 2 ,Macrophage Activation ,Cicatrix ,Liver ,Inflammation ,Diet ,High-Fat ,Cholesterol ,Lipids ,Mice ,Inbred C57BL ,Disease Models ,Animal - Abstract
Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and insulin-sensitizing effects have been largely unraveled, the mechanisms by which they alleviate liver injury have only been scarcely addressed. Here, we aimed to unveil the mechanisms underlying the protective effects of FGF21 on NASH using APOE*3-Leiden.CETP mice, a well-established model for human-like metabolic diseases. Liver-specific FGF21 overexpression was achieved in mice, followed by administration of a high-fat high-cholesterol diet for 23 weeks. FGF21 prevented hepatic lipotoxicity, accompanied by activation of thermogenic tissues and attenuation of adipose tissue inflammation, improvement of hyperglycemia and hypertriglyceridemia, and upregulation of hepatic programs involved in fatty acid oxidation and cholesterol removal. Furthermore, FGF21 inhibited hepatic inflammation, as evidenced by reduced Kupffer cell (KC) activation, diminished monocyte infiltration, and lowered accumulation of monocyte-derived macrophages. Moreover, FGF21 decreased lipid- and scar-associated macrophages, which correlated with less hepatic fibrosis as demonstrated by reduced collagen accumulation. Collectively, hepatic FGF21 overexpression limits hepatic lipotoxicity, inflammation, and fibrogenesis. Mechanistically, FGF21 blocks hepatic lipid influx and accumulation through combined endocrine and autocrine signaling, respectively, which prevents KC activation and lowers the presence of lipid- and scar-associated macrophages to inhibit fibrogenesis.
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- 2023
50. Prostate Cancer, Sexual Health, and Ageing Masculinities
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Andreasson, Jesper, primary and Johansson, Thomas, additional
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- 2024
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