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2. A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Author

Gutman, Boris A, Erp, Theo GM, Alpert, Kathryn, Ching, Christopher RK, Isaev, Dmitry, Ragothaman, Anjani, Jahanshad, Neda, Saremi, Arvin, Zavaliangos‐Petropulu, Artemis, Glahn, David C, Shen, Li, Cong, Shan, Alnæs, Dag, Andreassen, Ole Andreas, Doan, Nhat Trung, Westlye, Lars T, Kochunov, Peter, Satterthwaite, Theodore D, Wolf, Daniel H, Huang, Alexander J, Kessler, Charles, Weideman, Andrea, Nguyen, Dana, Mueller, Bryon A, Faziola, Lawrence, Potkin, Steven G, Preda, Adrian, Mathalon, Daniel H, Bustillo, Juan, Calhoun, Vince, Ford, Judith M, Walton, Esther, Ehrlich, Stefan, Ducci, Giuseppe, Banaj, Nerisa, Piras, Fabrizio, Piras, Federica, Spalletta, Gianfranco, Canales‐Rodríguez, Erick J, Fuentes‐Claramonte, Paola, Pomarol‐Clotet, Edith, Radua, Joaquim, Salvador, Raymond, Sarró, Salvador, Dickie, Erin W, Voineskos, Aristotle, Tordesillas‐Gutiérrez, Diana, Crespo‐Facorro, Benedicto, Setién‐Suero, Esther, Son, Jacqueline Mayoral, Borgwardt, Stefan, Schönborn‐Harrisberger, Fabienne, Morris, Derek, Donohoe, Gary, Holleran, Laurena, Cannon, Dara, McDonald, Colm, Corvin, Aiden, Gill, Michael, Filho, Geraldo Busatto, Rosa, Pedro GP, Serpa, Mauricio H, Zanetti, Marcus V, Lebedeva, Irina, Kaleda, Vasily, Tomyshev, Alexander, Crow, Tim, James, Anthony, Cervenka, Simon, Sellgren, Carl M, Fatouros‐Bergman, Helena, Agartz, Ingrid, Howells, Fleur, Stein, Dan J, Temmingh, Henk, Uhlmann, Anne, Zubicaray, Greig I, McMahon, Katie L, Wright, Margie, Cobia, Derin, Csernansky, John G, Thompson, Paul M, Turner, Jessica A, and Wang, Lei

Subjects
Brain Disorders, Mental Health, Neurosciences, Schizophrenia, Mental health, Good Health and Well Being, Amygdala, Corpus Striatum, Hippocampus, Humans, Multicenter Studies as Topic, Neuroimaging, Thalamus, schizophrenia, structure, subcortical shape, Cognitive Sciences, Experimental Psychology
Abstract

Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.

Published
2022

3. Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy

Author

Hjell, Gabriela, Rokicki, Jaroslav, Szabo, Attila, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Djurovic, Srdjan, Ueland, Thor, Andreassen, Ole Andreas, Melle, Ingrid, Lagerberg, Trine Vik, Mørch-Johnsen, Lynn, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2023
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5. Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals

Author

Argote, Mathilde, Sescousse, Guillaume, Brunelin, Jérôme, Baudin, Grégoire, Schaub, Michael Patrick, Rabin, Rachel, Schnell, Thomas, Ringen, Petter Andreas, Andreassen, Ole Andreas, Addington, Jean Margaret, Brambilla, Paolo, Delvecchio, Giuseppe, Bechdolf, Andreas, Wobrock, Thomas, Schneider-Axmann, Thomas, Herzig, Daniela, Mohr, Christine, Vila-Badia, Regina, Rodie, Judith Usall, Mallet, Jasmina, Ricci, Valerio, Martinotti, Giovanni, Knížková, Karolína, Rodriguez, Mabel, Cookey, Jacob, Tibbo, Philip, Scheffler, Freda, Asmal, Laila, Garcia-Rizo, Clemente, Amoretti, Silvia, Huber, Christian, Thibeau, Heather, Kline, Emily, Fakra, Eric, Jardri, Renaud, Nourredine, Mikail, and Rolland, Benjamin

Published
2023
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6. Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

Author

Petrov, Dmitry, Kuznetsov, Boris A. Gutman Egor, van Erp, Theo G. M., Turner, Jessica A., Schmaal, Lianne, Veltman, Dick, Wang, Lei, Alpert, Kathryn, Isaev, Dmitry, Zavaliangos-Petropulu, Artemis, Ching, Christopher R. K., Calhoun, Vince, Glahn, David, Satterthwaite, Theodore D., Andreassen, Ole Andreas, Borgwardt, Stefan, Howells, Fleur, Groenewold, Nynke, Voineskos, Aristotle, Radua, Joaquim, Potkin, Steven G., Crespo-Facorro, Benedicto, Tordesillas-Gutierrez, Diana, Shen, Li, Lebedeva, Irina, Spalletta, Gianfranco, Donohoe, Gary, Kochunov, Peter, Rosa, Pedro G. P., James, Anthony, Dannlowski, Udo, Baune, Bernhard T., Aleman, Andre, Gotlib, Ian H., Walter, Henrik, Walter, Martin, Soares, Jair C., Ehrlich, Stefan, Gur, Ruben C., Doan, N. Trung, Agartz, Ingrid, Westlye, Lars T., Harrisberger, Fabienne, Riecher-Rossler, Anita, Uhlmann, Anne, Stein, Dan J., Dickie, Erin W., Pomarol-Clotet, Edith, Fuentes-Claramonte, Paola, Canales-Rodriguez, Erick Jorge, Salvador, Raymond, Huang, Alexander J., Roiz-Santianez, Roberto, Cong, Shan, Tomyshev, Alexander, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Ciullo, Valentina, Hong, Elliot, Busatto, Geraldo, Zanetti, Marcus V., Serpa, Mauricio H., Cervenka, Simon, Kelly, Sinead, Grotegerd, Dominik, Sacchet, Matthew D., Veer, Ilya M., Li, Meng, Wu, Mon-Ju, Irungu, Benson, Walton, Esther, and Thompson, Paul M.

Subjects
Quantitative Biology - Neurons and Cognition
Abstract

We present several deep learning models for assessing the morphometric fidelity of deep grey matter region models extracted from brain MRI. We test three different convolutional neural net architectures (VGGNet, ResNet and Inception) over 2D maps of geometric features. Further, we present a novel geometry feature augmentation technique based on a parametric spherical mapping. Finally, we present an approach for model decision visualization, allowing human raters to see the areas of subcortical shapes most likely to be deemed of failing quality by the machine. Our training data is comprised of 5200 subjects from the ENIGMA Schizophrenia MRI cohorts, and our test dataset contains 1500 subjects from the ENIGMA Major Depressive Disorder cohorts. Our final models reduce human rater time by 46-70%. ResNet outperforms VGGNet and Inception for all of our predictive tasks., Comment: Accepted to Shape in Medical Imaging (ShapeMI) workshop at MICCAI 2018. arXiv admin note: substantial text overlap with arXiv:1707.06353

Published
2018

10. Interleukin-18 signaling system links to agitation in severe mental disorders

Author

Hjell, Gabriela, Szabo, Attila, Mørch-Johnsen, Lynn, Holst, René, Tesli, Natalia, Bell, Christina, Fischer-Vieler, Thomas, Werner, Maren Caroline Frogner, Lunding, Synve Hoffart, Ormerod, Monica Bettina Elkjær Greenwood, Johansen, Ingrid Torp, Dieset, Ingrid, Djurovic, Srdjan, Melle, Ingrid, Ueland, Thor, Andreassen, Ole Andreas, Steen, Nils Eiel, and Haukvik, Unn Kristin

Published
2022
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11. Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis

Author

Werner, Maren Caroline Frogner, Wirgenes, Katrine Verena, Shadrin, Alexey, Lunding, Synve Hoffart, Rødevand, Linn, Hjell, Gabriela, Ormerod, Monica Bettina Elkjær Greenwood, Haram, Marit, Agartz, Ingrid, Djurovic, Srdjan, Melle, Ingrid, Aukrust, Pål, Ueland, Thor, Andreassen, Ole Andreas, and Steen, Nils Eiel

Published
2022
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12. Is the familywise error rate in genomics controlled by methods based on the effective number of independent tests?

Author

Halle, Kari Krizak, Djurovic, Srdjan, Andreassen, Ole Andreas, and Langaas, Mette

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

In genome-wide association (GWA) studies the goal is to detect association between one or more genetic markers and a given phenotype. The number of genetic markers in a GWA study can be in the order hundreds of thousands and therefore multiple testing methods are needed. This paper presents a set of popular methods to be used to correct for multiple testing in GWA studies. All are based on the concept of estimating an effective number of independent tests. We compare these methods using simulated data and data from the TOP study, and show that the effective number of independent tests is not additive over blocks of independent genetic markers unless we assume a common value for the local significance level. We also show that the reviewed methods based on estimating the effective number of independent tests in general do not control the familywise error rate., Comment: 20 pages, 3 figures

Published
2016

13. Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Published
2021
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16. Roadmap for a precision-medicine initiative in the Nordic region

Author

Njølstad, Pål Rasmus, Andreassen, Ole Andreas, Brunak, Søren, Børglum, Anders D., Dillner, Joakim, Esko, Tõnu, Franks, Paul W., Freimer, Nelson, Groop, Leif, Heimer, Hakon, Hougaard, David M., Hovig, Eivind, Hveem, Kristian, Jalanko, Anu, Kaprio, Jaakko, Knudsen, Gun Peggy, Melbye, Mads, Metspalu, Andres, Mortensen, Preben Bo, Palmgren, Juni, Palotie, Aarno, Reed, Wenche, Stefánsson, Hreinn, Stitziel, Nathan O., Sullivan, Patrick F., Thorsteinsdóttir, Unnur, Vaudel, Marc, Vuorio, Eero, Werge, Thomas, Stoltenberg, Camilla, and Stefánsson, Kári

Published
2019
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17. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

Author

Demontis, Ditte, Walters, G. Bragi, Athanasiadis, Georgios, Walters, Raymond, Therrien, Karen, Nielsen, Trine Tollerup, Farajzadeh, Leila, Voloudakis, Georgios, Bendl, Jaroslav, Zeng, Biau, Zhang, Wen, Grove, Jakob, Als, Thomas D., Duan, Jinjie, Satterstrom, F. Kyle, Bybjerg-Grauholm, Jonas, Bækved-Hansen, Marie, Gudmundsson, Olafur O., Magnusson, Sigurdur H., Baldursson, Gisli, Davidsdottir, Katrin, Haraldsdottir, Gyda S., Agerbo, Esben, Hoffman, Gabriel E., Dalsgaard, Søren, Martin, Joanna, Ribasés, Marta, Boomsma, Dorret I., Soler Artigas, Maria, Roth Mota, Nina, Howrigan, Daniel, Medland, Sarah E., Zayats, Tetyana, Rajagopal, Veera M., Havdahl, Alexandra, Doyle, Alysa, Reif, Andreas, Thapar, Anita, Cormand, Bru, Liao, Calwing, Burton, Christie, Bau, Claiton H. D., Rovaris, Diego Luiz, Sonuga-Barke, Edmund, Corfield, Elizabeth, Grevet, Eugenio Horacio, Larsson, Henrik, Gizer, Ian R., Waldman, Irwin, Brikell, Isabell, Haavik, Jan, Crosbie, Jennifer, McGough, James, Kuntsi, Jonna, Glessner, Joseph, Langley, Kate, Lesch, Klaus-Peter, Rohde, Luis Augusto, Hutz, Mara H., Klein, Marieke, Bellgrove, Mark, Tesli, Martin, O’Donovan, Michael C., Andreassen, Ole Andreas, Leung, Patrick W. L., Pan, Pedro M., Joober, Ridha, Schachar, Russel, Loo, Sandra, Witt, Stephanie H., Reichborn-Kjennerud, Ted, Banaschewski, Tobias, Hawi, Ziarih, Daly, Mark J., Mors, Ole, Nordentoft, Merete, Hougaard, David M., Mortensen, Preben Bo, Faraone, Stephen V., Stefansson, Hreinn, Roussos, Panos, Franke, Barbara, Werge, Thomas, Neale, Benjamin M., Stefansson, Kari, Børglum, Anders D., APH - Methodology, APH - Mental Health, Amsterdam Reproduction & Development, and Biological Psychology

Subjects
Cognition, All institutes and research themes of the Radboud University Medical Center, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], SDG 3 - Good Health and Well-being, Genetics, Brain, Humans, Genetic Predisposition to Disease, Attention Deficit Disorder with Hyperactivity/genetics, Genome-Wide Association Study
Abstract

Contains fulltext : 290804.pdf (Publisher’s version ) (Closed access) Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development. Overall, ADHD genetic risk was associated with several brain-specific neuronal subtypes and midbrain dopaminergic neurons. In exome-sequencing data from 17,896 individuals, we identified an increased load of rare protein-truncating variants in ADHD for a set of risk genes enriched with probable causal common variants, potentially implicating SORCS3 in ADHD by both common and rare variants. Bivariate Gaussian mixture modeling estimated that 84-98% of ADHD-influencing variants are shared with other psychiatric disorders. In addition, common-variant ADHD risk was associated with impaired complex cognition such as verbal reasoning and a range of executive functions, including attention. 01 februari 2023

Published
2023
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21. Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals

Author

Argote, Mathilde; https://orcid.org/0000-0002-9344-0376, Sescousse, Guillaume, Brunelin, Jérôme; https://orcid.org/0000-0001-5479-5628, Baudin, Grégoire, Schaub, Michael Patrick; https://orcid.org/0000-0002-8375-4005, Rabin, Rachel, Schnell, Thomas, Ringen, Petter Andreas, Andreassen, Ole Andreas, Addington, Jean Margaret, Brambilla, Paolo, Delvecchio, Giuseppe, Bechdolf, Andreas, Wobrock, Thomas, Schneider-Axmann, Thomas, Herzig, Daniela, Mohr, Christine; https://orcid.org/0000-0002-3720-7115, Vila-Badia, Regina, Rodie, Judith Usall, Mallet, Jasmina, Ricci, Valerio; https://orcid.org/0000-0003-1717-2530, Martinotti, Giovanni, Knížková, Karolína; https://orcid.org/0000-0003-3069-6750, Rodriguez, Mabel, Cookey, Jacob, Tibbo, Philip, Scheffler, Freda, Asmal, Laila, Garcia-Rizo, Clemente; https://orcid.org/0000-0002-4855-1608, Amoretti, Silvia, et al, Argote, Mathilde; https://orcid.org/0000-0002-9344-0376, Sescousse, Guillaume, Brunelin, Jérôme; https://orcid.org/0000-0001-5479-5628, Baudin, Grégoire, Schaub, Michael Patrick; https://orcid.org/0000-0002-8375-4005, Rabin, Rachel, Schnell, Thomas, Ringen, Petter Andreas, Andreassen, Ole Andreas, Addington, Jean Margaret, Brambilla, Paolo, Delvecchio, Giuseppe, Bechdolf, Andreas, Wobrock, Thomas, Schneider-Axmann, Thomas, Herzig, Daniela, Mohr, Christine; https://orcid.org/0000-0002-3720-7115, Vila-Badia, Regina, Rodie, Judith Usall, Mallet, Jasmina, Ricci, Valerio; https://orcid.org/0000-0003-1717-2530, Martinotti, Giovanni, Knížková, Karolína; https://orcid.org/0000-0003-3069-6750, Rodriguez, Mabel, Cookey, Jacob, Tibbo, Philip, Scheffler, Freda, Asmal, Laila, Garcia-Rizo, Clemente; https://orcid.org/0000-0002-4855-1608, Amoretti, Silvia, and et al

Abstract

Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses. Yet, findings are inconsistent regarding negative symptoms, while other dimensions such as disorganization, depression, and excitement, have not been investigated. In addition, meta-analyses use aggregated data discarding important confounding variables which is a source of bias. Methods: PubMed, ScienceDirect and PsycINFO were used to search for publications from inception to September 27, 2022. We contacted the authors of relevant studies to extract raw datasets and perform an Individual Participant Data meta-analysis (IPDMA). Inclusion criteria were: psychopathology of individuals with schizophrenia spectrum disorders assessed by the Positive and Negative Syndrome Scale (PANSS); cannabis-users had to either have a diagnosis of cannabis use disorder or use cannabis at least twice a week. The main outcomes were the PANSS subscores extracted via the 3-factor (positive, negative and general) and 5-factor (positive, negative, disorganization, depression, excitement) structures. Preregistration is accessible via Prospero: ID CRD42022329172. Findings: Among the 1149 identified studies, 65 were eligible and 21 datasets were shared, totaling 3677 IPD and 3053 complete cases. The adjusted multivariate analysis revealed that relative to non-use, cannabis use was associated with higher severity of positive dimension (3-factor: Adjusted Mean Difference, aMD = 0.34, 95% Confidence Interval, CI = [0.03; 0.66]; 5-factor: aMD = 0.38, 95% CI = [0.08; 0.63]), lower severity of negative dimension (3-factor: aMD = -0.49, 95% CI [-0.90; -0.09]; 5-factor: aMD = -0.50, 95% CI = [-0.91; -0.08]), higher severity of excitement dimension (aMD = 0.16, 95% CI = [0.03; 0.28]). No association was found between cannabis use and disorganization (aMD = -0.13, 95% CI = [-0.42; 0.17]) or depression (aMD = -0.14, 95% CI = [-0.34; 0.06]). Interpre

Published
2023

23. Inflammation and cognition in severe mental illness: patterns of covariation and subgroups

Author

Sæther, Linn Sofie, primary, Ueland, Thor, additional, Haatveit, Beathe, additional, Maglanoc, Luigi Angelo, additional, Szabo, Attila, additional, Djurovic, Srdjan, additional, Aukrust, Pål, additional, Roelfs, Daniel, additional, Mohn, Christine, additional, Ormerod, Monica Bettina Elkjaer Greenwood, additional, Lagerberg, Trine Vik, additional, Steen, Nils Eiel, additional, Melle, Ingrid, additional, Andreassen, Ole Andreas, additional, and Ueland, Torill, additional

Published
2022
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27. Cigarette smoking is associated with thinner cingulate and insular cortices in patients with severe mental illness

Author

Jorgensen, Kjetil Nordbo, Skjaervo, Ingeborg, Morch-Johnsen, Lynn, Haukvik, Unn Kristin, Lange, Elisabeth Heffermehl, Melle, Ingrid, Andreassen, Ole Andreas, and Agartz, Ingrid

Subjects
Mentally ill -- Physiological aspects, Smoking -- Complications and side effects, Cingulate cortex -- Health aspects, Health, Psychology and mental health
Abstract

Background: Magnetic resonance imaging (MRI) studies show reduced cortical thickness in patients with schizophrenia and bipolar disorder. These subtle brain abnormalities may provide insight into illness mechanisms. However, environmental and lifestyle-related factors, such as cigarette smoking, may contribute to brain structure changes. Cigarette smoking is highly prevalent in patients with severe mental illness. In nonpsychiatric samples, smoking has been associated with reduced thickness in the anterior (ACC) and posterior cingulate cortices, the insular cortex (INS), the dorsolateral prefrontal cortex and the orbitofrontal cortex. Methods: We examined MRI scans from patients with schizophrenia, other psychotic disorders or bipolar disorder and healthy controls using FreeSurfer. Results: We included 506 patients (49% smokers) and 237 controls (20% smokers) in our study. We found reduced cortical thickness in the left rostral ACC and the left INS in smoking patients compared with nonsmoking patients, but this difference was not found among healthy controls. No dose-response relationship was found between amount of smoking and cortical thickness in these regions. Among patients, maps of thickness along the whole cortical surface revealed reduced insular thickness but no effects in other regions. Among healthy controls, similar analyses revealed increased age-related cortical thinning in the left occipital lobe among smokers compared with nonsmokers. Limitations: The causal direction could not be determined owing to the cross-sectional design and lack of detailed data on smoking addiction and smoking history. Conclusion: The effect of cigarette smoking should be considered in MRI studies of patients with severe mental illness., Introduction Widespread reductions in cerebral cortical thickness have been documented in MRI studies of patients with first-episode (1-3) and chronic schizophrenia. (4,5) In patients with bipolar I disorder, a more [...]

Published
2015
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33. Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study

Author

Engh, John Abel, primary, Ueland, Thor, additional, Agartz, Ingrid, additional, Andreou, Dimitrios, additional, Aukrust, Pål, additional, Boye, Birgitte, additional, Bøen, Erlend, additional, Drange, Ole Kristian, additional, Elvsåshagen, Torbjørn, additional, Hope, Sigrun, additional, Høegh, Margrethe Collier, additional, Joa, Inge, additional, Johnsen, Erik, additional, Kroken, Rune Andreas, additional, Lagerberg, Trine Vik, additional, Lekva, Tove, additional, Malt, Ulrik Fredrik, additional, Melle, Ingrid, additional, Morken, Gunnar, additional, Nærland, Terje, additional, Steen, Vidar Martin, additional, Wedervang-Resell, Kirsten, additional, Weibell, Melissa Auten, additional, Westlye, Lars Tjelta, additional, Djurovic, Srdjan, additional, Steen, Nils Eiel, additional, and Andreassen, Ole Andreas, additional

Published
2021
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34. A meta‐analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

Author

Gutman, Boris A., primary, Erp, Theo G.M., additional, Alpert, Kathryn, additional, Ching, Christopher R. K., additional, Isaev, Dmitry, additional, Ragothaman, Anjani, additional, Jahanshad, Neda, additional, Saremi, Arvin, additional, Zavaliangos‐Petropulu, Artemis, additional, Glahn, David C., additional, Shen, Li, additional, Cong, Shan, additional, Alnæs, Dag, additional, Andreassen, Ole Andreas, additional, Doan, Nhat Trung, additional, Westlye, Lars T., additional, Kochunov, Peter, additional, Satterthwaite, Theodore D., additional, Wolf, Daniel H., additional, Huang, Alexander J., additional, Kessler, Charles, additional, Weideman, Andrea, additional, Nguyen, Dana, additional, Mueller, Bryon A., additional, Faziola, Lawrence, additional, Potkin, Steven G., additional, Preda, Adrian, additional, Mathalon, Daniel H., additional, Bustillo, Juan, additional, Calhoun, Vince, additional, Ford, Judith M., additional, Walton, Esther, additional, Ehrlich, Stefan, additional, Ducci, Giuseppe, additional, Banaj, Nerisa, additional, Piras, Fabrizio, additional, Piras, Federica, additional, Spalletta, Gianfranco, additional, Canales‐Rodríguez, Erick J., additional, Fuentes‐Claramonte, Paola, additional, Pomarol‐Clotet, Edith, additional, Radua, Joaquim, additional, Salvador, Raymond, additional, Sarró, Salvador, additional, Dickie, Erin W., additional, Voineskos, Aristotle, additional, Tordesillas‐Gutiérrez, Diana, additional, Crespo‐Facorro, Benedicto, additional, Setién‐Suero, Esther, additional, Son, Jacqueline Mayoral, additional, Borgwardt, Stefan, additional, Schönborn‐Harrisberger, Fabienne, additional, Morris, Derek, additional, Donohoe, Gary, additional, Holleran, Laurena, additional, Cannon, Dara, additional, McDonald, Colm, additional, Corvin, Aiden, additional, Gill, Michael, additional, Filho, Geraldo Busatto, additional, Rosa, Pedro G. P., additional, Serpa, Mauricio H., additional, Zanetti, Marcus V., additional, Lebedeva, Irina, additional, Kaleda, Vasily, additional, Tomyshev, Alexander, additional, Crow, Tim, additional, James, Anthony, additional, Cervenka, Simon, additional, Sellgren, Carl M, additional, Fatouros‐Bergman, Helena, additional, Agartz, Ingrid, additional, Howells, Fleur, additional, Stein, Dan J., additional, Temmingh, Henk, additional, Uhlmann, Anne, additional, Zubicaray, Greig I., additional, McMahon, Katie L., additional, Wright, Margie, additional, Cobia, Derin, additional, Csernansky, John G., additional, Thompson, Paul M., additional, Turner, Jessica A., additional, and Wang, Lei, additional

Published
2021
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36. Additional file 4 of Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Subjects
surgical procedures, operative, bacterial infections and mycoses, neoplasms, digestive system, digestive system diseases
Abstract

Additional file 4: Appendix Text 1: Associations between explored psychiatric symptoms.

Published
2021
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37. Additional file 1 of Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Subjects
mental disorders, behavioral disciplines and activities
Abstract

Additional file 1: Table A Sensitivity analysis: Associations between depressive symptoms and suPAR, multivariable regression analyses in participants with schizophrenia.

Published
2021
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38. Additional file 5 of Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Abstract

Additional file 5: Appendix Text 2 - Exploration of the relationship between hsCRP and depressive symptoms beyond CDSS sum score.

Published
2021
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39. Additional file 3 of Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Abstract

Additional file 3:. Metabolic risk associated with antipsychotic medication.

Published
2021
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40. Additional file 2 of Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Subjects
health care facilities, manpower, and services, mental disorders, education, behavioral disciplines and activities, health care economics and organizations
Abstract

Additional file 2: Table B1 Internal reliability of the Norwegian version of the Calgary Depression Scale for Schizophrenia. Table B2 Internal reliability of the Norwegian version of the Calgary Depression Scale for Schizophrenia, by sex.

Published
2021
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41. Interleukin-1 Family Signaling Related to Agitation in Severe Mental Disorders

Author

Hjell, Gabriela, primary, Szabo, Attila, additional, Mørch-Johnsen, Lynn, additional, Holst, René, additional, Tesli, Natalia, additional, Bell, Christina, additional, Fisher-Vieler, Thomas, additional, Frogner Werner, Maren Caroline, additional, Lunding, Synve Hoffart, additional, Ormerod, Monica, additional, Dieset, Ingrid, additional, Djurovic, Srdjan, additional, Melle, Ingrid, additional, Ueland, Thor, additional, Andreassen, Ole Andreas, additional, Steen, Nils Eiel, additional, and Haukvik, Unn Kristin, additional

Published
2021
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42. Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia:a sex-dependent association with depressive symptoms

Author

Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, Fredriksen, Mats, Bigseth, Therese Torgersen, Engh, John Abel, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sørum, Holmen, Tom Langerud, Lindberg, Morten, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Fredriksen, Mats

Abstract

Background: There is evidence of increased low grade inflammation (LGI) in schizophrenia patients. However, the inter-individual variation is large and the association with demographic, somatic and psychiatric factors remains unclear. Our aim was to explore whether levels of the novel LGI marker soluble urokinase plasminogen activator receptor (suPAR) were associated with clinical factors in schizophrenia and if such associations were sex-dependent. Method: In this observational study a total of 187 participants with schizophrenia (108 males, 79 females) underwent physical examination and assessment with clinical interviews (Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Alcohol Use Disorder Identification Test (AUDIT), and Drug Use Disorder Identification Test (DUDIT)). Blood levels of suPAR, glucose, lipids, and high sensitivity C-reactive protein (hsCRP) were determined and body mass index (BMI) calculated. Multivariable linear regression analyses were used adjusting for confounders, and sex interaction tested in significant variables. Results: Adjusting for sex, age, current tobacco smoking and BMI, we found that levels of hsCRP and depressive symptoms (CDSS) were positively associated with levels of suPAR (p < 0.001). The association between suPAR and CDSS score was significant in females (p < 0.001) but not in males. Immune activation measured by hsCRP was not associated with depressive symptoms after adjusting for BMI. Conclusion: Our findings indicate that increased suPAR levels are associated with depressive symptoms in females with schizophrenia, suggesting aberrant immune activation in this subgroup. Our results warrant further studies, including longitudinal follow-up of suPAR levels in schizophrenia and experimental studies of mechanisms.

Published
2021

43. Elevated levels of soluble urokinase plasminogen activator receptor as a low-grade inflammation marker in schizophrenia:A case-control study

Author

Bigseth, Therese Torgersen, Fredriksen, Mats, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sorum, Holmen, Tom Langerud, Martinsen, Egil Wilhelm, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, Engh, John Abel, Bigseth, Therese Torgersen, Fredriksen, Mats, Egeland, Jens, Andersen, Eivind, Andreassen, Ole Andreas, Bang-Kittilsen, Gry, Falk, Ragnhild Sorum, Holmen, Tom Langerud, Martinsen, Egil Wilhelm, Mordal, Jon, Nielsen, Jimmi, Steen, Nils Eiel, Ueland, Thor, Vang, Torkel, and Engh, John Abel

Published
2021

44. Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders

Author

Hjell, Gabriela, primary, Mørch‐Johnsen, Lynn, additional, Holst, René, additional, Tesli, Natalia, additional, Bell, Christina, additional, Lunding, Synve Hoffart, additional, Rødevand, Linn, additional, Werner, Maren Caroline Frogner, additional, Melle, Ingrid, additional, Andreassen, Ole Andreas, additional, Lagerberg, Trine Vik, additional, Steen, Nils Eiel, additional, and Haukvik, Unn Kristin, additional

Published
2020
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46. Genome-wide association study identifies 30 loci associated with bipolar disorder

Author

Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco P., Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alxander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders, de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, Depaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tifany A., Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Shannon Weickert, Cynthia, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav Bjerkehagen, Sobell, Janet L., Søholm Hansen, Christine, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E, Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zöllner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kirov, George, Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C, Ødegaard, Ketil Joachim, Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne, Vieta, Eduard, Vincent, John B., Werge, Thomas, Nurnberger, John I., Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole Andreas, Kelsoe, John, and Sklar, Pamela

Abstract

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P

Published
2019

47. The Association Between Cardiorespiratory Fitness and Cognition Appears Neither Related to Current Physical Activity Nor Mediated by Brain-Derived Neurotrophic Factor in a Sample of Outpatients With Schizophrenia

Author

Holmen, Tom Langerud, primary, Egeland, Jens, additional, Andersen, Eivind, additional, Mordal, Jon, additional, Andreassen, Ole Andreas, additional, Ueland, Thor, additional, Bigseth, Therese Torgersen, additional, Bang-Kittilsen, Gry, additional, and Engh, John Abel, additional

Published
2019
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48. High levels of anomalous self-experience are associated with longer duration of untreated psychosis

Author

Haug, Elisabeth, Øie, Merete Glenne, Andreassen, Ole Andreas, Bratlien, Unni, Barnaby, Nelson, Melle, Ingrid, and Møller, Paul

Subjects
Psychotic Disorders, Schizophrenia, Self, Early intervention
Abstract

Citation: Elisabeth Haug, Merete G. Øie, Ole A. Andreassen, Unni Bratlien, Kristin L. Romm, Paul Møller and Ingrid Melle, The Association between Anomalous Self-experiences, Self-esteem and Depressive Symptoms in First Episode Schizophrenia, Frontiers in Human Neuroscience, 10, (2016). Aim To investigate the relationship between anomalous self-experiences and duration of untreated psychosis in a sample of patients with first episode schizophrenia spectrum disorders. Methods Anomalous self-experiences were assessed by means of the Examination of Anomalous Self-Experience manual in 55 patients referred to their first adequate treatment for schizophrenia. Diagnoses, symptom severity, functioning and childhood trauma were assessed using the Structured Clinical Interview for the Positive and Negative Syndrome Scale, Premorbid Adjustment Scale, Social Functioning Scale and Childhood trauma questionnaire. Substance misuse was measured with the Drug Use Disorder Identification Test, and alcohol use was measured with the Alcohol Use Disorder Identification Test. Duration of untreated psychosis was measured in accordance with a standardized procedure. Results High levels of anomalous self-experiences are significantly associated with longer duration of untreated psychosis, an association which held after correcting for other variables associated with long duration of untreated psychosis. Conclusions The field of early detection in psychosis is in need of additional clinical perspectives to make further progress. Improved understanding and assessment of anomalous self-experiences may help clinicians to detect these important phenomena and provide earlier help, and thus reduce treatment delay. This work was supported by Innlandet Hospital Trust (grant number 150229)

Published
2017

50. The association between anomalous self-experiences, self-esteem and depression in first episode schizophrenia

Author

Haug, Elisabeth, Øie, Merete Glenne, Andreassen, Ole Andreas, Møller, Paul, Melle, Ingrid, Romm, Kristin Lie, and Bratlien, Unni

Subjects
schizophrenia, self-esteem, childhood trauma, gender differences, depression, first episode psychosis, anomalous self-experiences
Abstract

Funding for this study was provided by Innlandet Hospital Trust (grant number 150229) and the Regional Health Authority of South-Eastern Norway (grant numbers, 2006258, 2008058, and 2011085). The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Published
2016

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