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1. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours

Author

Mapelli, P., Bezzi, C., Palumbo, D., Canevari, C., Ghezzo, S., Samanes Gajate, A. M., Catalfamo, B., Messina, A., Presotto, L., Guarnaccia, A., Bettinardi, V., Muffatti, F., Andreasi, V., Schiavo Lena, M., Gianolli, L., Partelli, S., Falconi, M., Scifo, P., De Cobelli, F., and Picchio, M.

Published
2022
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4. Second primary neoplasms in patients with lung and gastroenteropancreatic neuroendocrine neoplasms: Data from a retrospective multi-centric study

Author

Massironi, S., Campana, D., Pusceddu, S., Albertelli, M., Faggiano, A., Panzuto, F., Smiroldo, V., Andreasi, V., Rossi, R.E., Maggio, I., Torchio, M., Dotto, A., Modica, R., Rinzivillo, M., Carnaghi, C., Partelli, S., Fanetti, I., Lamberti, G., Corti, F., Ferone, D., Colao, A., Annibale, B., Invernizzi, P., and Falconi, M.

Published
2021
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5. BOOTSTRAP-BASED MACHINE LEARNING TO ROBUSTLY CHARACTERIZE PANCREATIC NEUROENDOCRINE NEOPLASMS (PANNEN) BASED ON CT RADIOMIC FEATURES

Author

Mori, M., primary, Palumbo, D., additional, Muffatti, F., additional, Partelli, S., additional, Mushtaq, J., additional, Andreasi, V., additional, Prato, F., additional, Ubeira-Gabellini, M.G., additional, Palazzo, G., additional, Falconi, M., additional, Del Vecchio, A., additional, De Cobelli, F., additional, and Fiorino, C., additional

Published
2023
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14. Preoperative assessment of microvessel density in nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs)

Author

Battistella, Anna, primary, Partelli, S., additional, Andreasi, V., additional, Marinoni, I., additional, Palumbo, D., additional, Tacelli, M., additional, Lena, M. Schiavo, additional, Mushtaq, J., additional, Muffatti, F., additional, Capurso, G., additional, Arcidiacono, P., additional, De Cobelli, F., additional, Doglioni, C., additional, Perren, A., additional, and Falconi, M., additional

Published
2022
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15. OC.03.6 DUODENAL GASTRIC METAPLASIA AND DUODENAL NEUROENDOCRINE NEOPLASMS: TRUE CAUSALITY OR SIMPLE COINCIDENCE?

Author

Rossi, R.E., primary, Milanetto, A.C., additional, Andreasi, V., additional, Campana, D., additional, Coppa, J., additional, Nappo, G., additional, Rinzivillo, M., additional, Invernizzi, P., additional, Modica, R., additional, Partelli, S., additional, Zerbi, A., additional, Panzuto, F., additional, Pasquali, C., additional, Falconi, M., additional, and Massironi, S., additional

Published
2022
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16. Association of Upfront Peptide Receptor Radionuclide Therapy With Progression-Free Survival Among Patients With Enteropancreatic Neuroendocrine Tumors

Author

Ricci, C., Pusceddu, S., Prinzi, N., Tafuto, S., Ibrahim, T., Filice, A., Brizzi, M. P., Panzuto, F., Baldari, S., Grana, C. M., Campana, D., Davi, M. V., Giuffrida, D., Zatelli, M. C., Partelli, S., Razzore, P., Marconcini, R., Massironi, S., Gelsomino, F., Faggiano, A., Giannetta, E., Bajetta, E., Grimaldi, F., Cives, M., Cirillo, F., Perfetti, V., Corti, F., Giacomelli, L., Porcu, L., Di Maio, M., Seregni, E., Maccauro, M., Lastoria, S., Bongiovanni, A., Versari, A., Persano, I., Rinzivillo, M., Pignata, S. A., Rocca, P. A., Lamberti, G., Cingarlini, S., Puliafito, I., Ambrosio, M. R., Zanata, I., Bracigliano, A., Severi, S., Spada, F., Andreasi, V., Modica, R., Scalorbi, F., Milione, M., Sabella, G., Coppa, J., Casadei, R., Di Bartolomeo, M., Falconi, M., De Braud, F., Pusceddu, Sara, Prinzi, Natalie, Tafuto, Salvatore, Ibrahim, Toni, Filice, Angelina, Brizzi, Maria Pia, Panzuto, Francesco, Baldari, Sergio, Grana, Chiara M., Campana, Davide, Davì, Maria Vittoria, Giuffrida, Dario, Zatelli, Maria Chiara, Partelli, Stefano, Razzore, Paola, Marconcini, Riccardo, Massironi, Sara, Gelsomino, Fabio, Faggiano, Antongiulio, Giannetta, Elisa, Bajetta, Emilio, Grimaldi, Franco, Cives, Mauro, Cirillo, Fernando, Perfetti, Vittorio, Corti, Francesca, Ricci, Claudio, Giacomelli, Luca, Porcu, Luca, Di Maio, Massimo, Seregni, Ettore, Maccauro, Marco, Lastoria, Secondo, Bongiovanni, Alberto, Versari, Annibale, Persano, Irene, Rinzivillo, Maria, Pignata, Salvatore Antonio, Rocca, Paola Anna, Lamberti, Giuseppe, Cingarlini, Sara, Puliafito, Ivana, Ambrosio, Maria Rosaria, Zanata, Isabella, Bracigliano, Alessandra, Severi, Stefano, Spada, Francesca, Andreasi, Valentina, Modica, Roberta, Scalorbi, Federica, Milione, Massimo, Sabella, Giovanna, Coppa, Jorgelina, Casadei, Riccardo, Di Bartolomeo, Maria, Falconi, Massimo, de Braud, Filippo, Grana, Chiara M, and Davi, Maria Vittoria

Subjects
Male, Radiotherapy, Receptors, Peptide, General Medicine, sequence, Middle Aged, peptide receptors radionuclide therapy, everolimus, chemotherapy, Progression-Free Survival, NO, Peptide Receptor Radionuclide Therapy, Pancreatic Neoplasms, Neuroendocrine Tumors, receptor radionuclide therapy, enteropancreatic neuroendocrine tumors, progression free survival, Receptors, Peptide, Humans, Female, LS4_3, neuroendocrine tumors, sequence, everolimus, Retrospective Studies
Abstract

Importance: Data about the optimal timing for the initiation of peptide receptor radionuclide therapy (PRRT) for advanced, well-differentiated enteropancreatic neuroendocrine tumors are lacking. Objective: To evaluate the association of upfront PRRT vs upfront chemotherapy or targeted therapy with progression-free survival (PFS) among patients with advanced enteropancreatic neuroendocrine tumors who experienced disease progression after treatment with somatostatin analogues (SSAs). Design, setting, and participants: This retrospective, multicenter cohort study analyzed the clinical records from 25 Italian oncology centers for patients aged 18 years or older who had unresectable, locally advanced or metastatic, well-differentiated, grades 1 to 3 enteropancreatic neuroendocrine tumors and received either PRRT or chemotherapy or targeted therapy after experiencing disease progression after treatment with SSAs between January 24, 2000, and July 1, 2020. Propensity score matching was done to minimize the selection bias. Exposures: Upfront PRRT or upfront chemotherapy or targeted therapy. Main outcomes and measures: The main outcome was the difference in PFS among patients who received upfront PRRT vs among those who received upfront chemotherapy or targeted therapy. A secondary outcome was the difference in overall survival between these groups. Hazard ratios (HRs) were fitted in a multivariable Cox proportional hazards regression model to adjust for relevant factors associated with PFS and were corrected for interaction with these factors. Results: Of 508 evaluated patients (mean ([SD] age, 55.7 [0.5] years; 278 [54.7%] were male), 329 (64.8%) received upfront PRRT and 179 (35.2%) received upfront chemotherapy or targeted therapy. The matched group included 222 patients (124 [55.9%] male; mean [SD] age, 56.1 [0.8] years), with 111 in each treatment group. Median PFS was longer in the PRRT group than in the chemotherapy or targeted therapy group in the unmatched (2.5 years [95% CI, 2.3-3.0 years] vs 0.7 years [95% CI, 0.5-1.0 years]; HR, 0.35 [95% CI, 0.28-0.44; P

Published
2022

23. The role of acinar content at pancreatic resection margin in the development of postoperative pancreatic fistula and acute pancreatitis after pancreaticoduodenectomy

Author

Andreasi, V., primary, Partelli, S., additional, Schiavo Lena, M., additional, Rancoita, P.M.V., additional, Mazza, M., additional, Mele, S., additional, Guarneri, G., additional, Pecorelli, N., additional, Crippa, S., additional, Tamburrino, D., additional, Doglioni, C., additional, and Falconi, M., additional

Published
2021
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27. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours.

Author

Mapelli, P., Bezzi, C., Palumbo, D., Canevari, C., Ghezzo, S., Samanes Gajate, A. M., Catalfamo, B., Messina, A., Presotto, L., Guarnaccia, A., Bettinardi, V., Muffatti, F., Andreasi, V., Schiavo Lena, M., Gianolli, L., Partelli, S., Falconi, M., Scifo, P., De Cobelli, F., and Picchio, M.

Subjects
SOMATOSTATIN, HISTOPATHOLOGY, NEUROENDOCRINE tumors, TUMORS, NEUROENDOCRINE system
Abstract

Purpose: To explore the role of fully hybrid 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine tumours (PanNETs) undergoing surgery. Methods: One hundred eighty-seven consecutive 68Ga-DOTATOC PET/MRI scans (March 2018–June 2020) performed for gastroenteropancreatic neuroendocrine tumour were retrospectively evaluated; 16/187 patients met the eligibility criteria (68Ga-DOTATOC PET/MRI for preoperative staging of PanNET and availability of histological data). PET/MR scans were qualitatively and quantitatively interpreted, and the following imaging parameters were derived: PET-derived SUVmax, SUVmean, somatostatin receptor density (SRD), total lesion somatostatin receptor density (TLSRD), and MRI-derived apparent diffusion coefficient (ADC), arterial and late enhancement, necrosis, cystic degeneration, and maximum diameter. Additionally, first-, second-, and higher-order radiomic parameters were extracted from both PET and MRI scans. Correlations with several PanNETs' histopathological prognostic factors were evaluated using Spearman's coefficient, while the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate parameters' predictive performance. Results: Primary tumour was detected in all 16 patients (15/16 by 68Ga-DOTATOC PET and 16/16 by MRI). SUVmax and SUVmean resulted good predictors of lymphnodal (LN) involvement (AUC of 0.850 and 0.783, respectively). Second-order radiomic parameters GrayLevelVariance and HighGrayLevelZoneEmphasis extracted from T2 MRI demonstrated significant correlations with LN involvement (adjusted p = 0.009), also showing good predictive performance (AUC = 0.992). Conclusion: This study demonstrates the role of the fully hybrid PET/MRI tool for the synergic function of imaging parameters extracted by the two modalities and highlights the potentiality of imaging and radiomic parameters in assessing histopathological features of PanNET aggressiveness. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis

Author

Ricci, C, primary, Partelli, S, additional, Landoni, L, additional, Rinzivillo, M, additional, Ingaldi, C, additional, Andreasi, V, additional, Nessi, C, additional, Muffatti, F, additional, Fontana, M, additional, Tamburrino, D, additional, Deiro, G, additional, Alberici, L, additional, Campana, D, additional, Panzuto, F, additional, Bassi, C, additional, Falconi, M, additional, and Casadei, R, additional

Published
2021
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34. The number of positive nodes accurately predicts recurrence after distal pancreatectomy for nonfunctioning neuroendocrine neoplasms

Author

Guarneri, G., primary, De Mestier, L., additional, Landoni, L., additional, Gaujoux, S., additional, Andreasi, V., additional, Partelli, S., additional, Nessi, C., additional, Fontana, M., additional, Ruszniewski, P., additional, Dokmak, S., additional, Dousset, B., additional, Bassi, C., additional, Falconi, M., additional, and Sauvanet, A., additional

Published
2020
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38. T03.01.15 SECOND PRIMARY NEOPLASMS IN PATIENTS WITH GASTRO-ENTERO-PANCREATIC NEUROENDOCRINE NEOPLASMS (GEP-NEN): DATA FROM A RETROSPECTIVE IT.A.NET STUDY

Author

Massironi, S., primary, Campana, D., additional, Pusceddu, S., additional, Albertelli, M., additional, Faggiano, A., additional, Panzuto, F., additional, Smiroldo, V., additional, Andreasi, V., additional, Rossi, R.E., additional, Maggio, I., additional, Torchio, M., additional, Ambrosetti, E., additional, Modica, R., additional, Rinzivillo, M., additional, Carnaghi, C., additional, Partelli, S., additional, Fanetti, I., additional, Lamberti, G., additional, Corti, F., additional, Dotto, A., additional, Colao, A., additional, Annibale, B., additional, Falconi, M., additional, and Invernizzi, P., additional

Published
2020
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39. The prognostic value of C-reactive protein in a new preoperative clinical risk score for survival after surgery for sporadic, non-functioning pancreatic neuroendocrine neoplasia: An international multicentre study

Author

Primavesi, F., primary, Andreasi, V., additional, Hoogwater, F.J.H., additional, Partelli, S., additional, Klieser, E., additional, Cardini, B., additional, Marsoner, K., additional, Fröschl, U., additional, Thalhammer, S., additional, Fischer, I., additional, Takkenkamp, T., additional, Hauer, A., additional, Urbas, U., additional, Kiesslich, T., additional, Neureiter, D., additional, Zitt, M., additional, Klug, R., additional, Wundsam, H., additional, Sellner, F., additional, Függer, R., additional, Cakar-Beck, F., additional, Kornprat, P., additional, Öfner, D., additional, De Kleine, R.H.J., additional, Falconi, M., additional, and Stättner, S., additional

Published
2020
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42. Outcome of surgical resection after neoadjuvant peptide receptor radionuclide therapy (PRRT) for pancreatic neuroendocrine neoplasms: A case-matched analysis

Author

Muffatti, F., primary, Piccioli, A.N., additional, Partelli, S., additional, Andreasi, V., additional, Bertani, E., additional, Bartolomei, M., additional, Chiara Maria, G., additional, Zamboni, G., additional, Doglioni, C., additional, Fazio, N., additional, and Falconi, M., additional

Published
2018
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48. Role of pre-operative inflammatory markers as predictors of lymph node positivity and disease recurrence in well-differentiated pancreatic neuroendocrine tumours. Study group affiliation: Pancreas2000 Research and educational program (course 9).

Author

Tanno, Lulu, Pea, A., Partelli, S., Andreasi, V., Falconi, M., Nappo, G., Rajput, K., Baron, R., Butturini, G., Oba, A., Siebenhüner, A., Yılmaz, B., Ceyhan, G., Nykänen, T., Marchegiani, G., and Robinson, S.

Published
2022
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