23 results on '"Andreas Borta"'
Search Results
2. Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
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Mareike Ernst, Elmar Brähler, Daniëlle Otten, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Felix Wicke, Jörg Wiltink, Matthias Michal, Markus Nagler, Thomas Münzel, Philipp S. Wild, Jochem König, Norbert Pfeiffer, Andreas Borta, Karl J. Lackner, and Manfred E. Beutel
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Medicine ,Science - Abstract
Abstract Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.
- Published
- 2021
- Full Text
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3. Preclinical Proof-of-concept of a Novel AAV9-microRNA based Targeting of GRIK2 for the Treatment of Temporal Lobe Epilepsy (S44.001)
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Nick Pearson, Stephane Baudouin, Morgane Wartel, Sonay Keskin, Olivier Danos, Christophe Mulle, Nicolas Partouche, Valérie Crépel, Andreas Borta, and Richard Porter
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- 2023
4. N°185 – Development of gene therapy for Temporal Lobe Epilepsy using organotypic hippocampal culture from patients and animal models
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Severine Deforges, Celine Boileau, Nicolas Partouche, Fabrice Bartolomei, Didier Scavarda, Guillaume Penchet, Cecile Marchal, Stephane Baudouin, Andreas Borta, Richard Porter, Christophe Mulle, and Valerie Crepel
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Neurology ,Physiology (medical) ,Neurology (clinical) ,Sensory Systems - Published
- 2023
5. Course of depressive symptoms in men and women: differential effects of social, psychological, behavioral and somatic predictors
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Mareike Ernst, Thomas Münzel, Matthias Michal, Norbert Pfeiffer, Ana N. Tibubos, Philipp S. Wild, Manfred E. Beutel, Jasmin Ghaemi Kerahrodi, Irene Schmidtmann, Elmar Brähler, Juliane Burghardt, Joerg Wiltink, Carlotta Baumgarten, Karl J. Lackner, Andreas Schulz, and Andreas Borta
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Adult ,Male ,Multivariate analysis ,Epidemiology ,media_common.quotation_subject ,Health Behavior ,lcsh:Medicine ,Logistic regression ,Article ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Sex Factors ,Risk Factors ,Personality ,Medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,lcsh:Science ,Depression (differential diagnoses) ,Depressive symptoms ,media_common ,Univariate analysis ,Depressive Disorder ,Public health ,Multidisciplinary ,business.industry ,Type D personality ,lcsh:R ,Social Support ,Middle Aged ,Female ,lcsh:Q ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
In this study, we aimed to identify the most important and sex-specific social, psychological, behavioral and somatic predictors of recurrent depressive symptoms. Data was obtained at two measurement points within five years by the Gutenberg Health Study (GHS). Out of N = 12,061 individuals, a sample of 877 (age 52.3 ± 9.9) who reported clinically relevant depressive symptoms at baseline was analyzed. Univariate analyses and multiple logistic regression analyses were conducted. Almost half of participants depressed at baseline also reported depressive symptoms five years later. Sex-stratified multivariate analyses revealed that solely social support remained a significant protective predictor against recurrence of depression in men (OR = 0.93; CI95% = 0.87–0.99), whereas in women smoking (OR = 1.97; CI95% = 1.23–3.22), and Type D personality (OR = 1.65; CI95% = 1.10–2.49) were significant risk factors. However, when analyzing the entire sample, no interaction effect between sex and each predictor turned out to be significant. Only social support was retained as an overall predictive factor. As depressive symptoms recur, depressive vulnerability is established involving personality, health behavior and social factors. Although no significant sex-specific interactions were observed, sex-stratified analyses point out different patterns for relevant predictors of recurrent depressive symptoms in men and women.
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- 2019
6. Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort
- Author
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Jörg Wiltink, Philipp S. Wild, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Ana N. Tibubos, Matthias Michal, Jochem König, Elmar Brähler, Felix Wicke, Mareike Ernst, Andreas Borta, Markus Nagler, Manfred E. Beutel, Iris Reiner, Antonia M. Werner, and Daniëlle Otten
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Male ,medicine.medical_specialty ,Science ,Logistic regression ,Article ,Cohort Studies ,03 medical and health sciences ,Leukocyte Count ,0302 clinical medicine ,Medical research ,Residence Characteristics ,Internal medicine ,Human behaviour ,Medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Depression (differential diagnoses) ,Inflammation ,Public health ,Multidisciplinary ,business.industry ,Depression ,Cancer ,Loneliness ,Middle Aged ,medicine.disease ,030227 psychiatry ,Patient Health Questionnaire ,C-Reactive Protein ,Logistic Models ,Risk factors ,Cohort ,Etiology ,Female ,medicine.symptom ,business ,Psychiatric disorders ,030217 neurology & neurosurgery ,Biomarkers ,Follow-Up Studies - Abstract
Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.
- Published
- 2021
7. Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway
- Author
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Iris-Tatjana Kolassa, Alexander Karabatsiakis, Patrick Fissler, Alexander Woll, Franka Thurm, Christine A. F. von Arnim, Patrick Weydt, Bastian Hengerer, Martina Zügel, Andreas Borta, Björn von Einem, Olivia C. Küster, Sina Pleiner, Daria Laptinskaya, Cathrin Schnack, Verena Nold, and André Liesener
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Male ,0301 basic medicine ,medicine.medical_specialty ,Kynurenine pathway ,Neuropsychological Tests ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Tandem Mass Spectrometry ,Internal medicine ,medicine ,Humans ,Dementia ,Cognitive decline ,Life Style ,Kynurenine ,Aged ,Aged, 80 and over ,Brain-derived neurotrophic factor ,Cognitive Behavioral Therapy ,Brain-Derived Neurotrophic Factor ,General Neuroscience ,Cognition ,General Medicine ,Middle Aged ,medicine.disease ,Executive functions ,Cognitive training ,Fibronectins ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Endocrinology ,chemistry ,Female ,Geriatrics and Gerontology ,Psychology ,Stress, Psychological ,030217 neurology & neurosurgery ,Physical Conditioning, Human ,Signal Transduction ,Clinical psychology - Abstract
Psychosocial stress and physical, cognitive, and social activity predict the risk of cognitive decline and dementia. The aim of this study was to elucidate brain-derived neurotrophic factor (BDNF), irisin, and the kynurenine pathway (KP) as potential underlying biological correlates. We evaluated associations of irisin and the KP with BDNF in serum and with cognition, stress, and activities. Furthermore, changes in serum concentrations of BDNF, irisin, and KP metabolites were investigated after physical or cognitive training. Forty-seven older adults at risk of dementia were assigned to 10 weeks of physical training, cognitive training, or a wait-list control condition. Previous physical, cognitive, and social activities and stressful life events were recorded; global cognition, episodic memory, and executive functions were assessed. Serum levels of L-kynurenine, kynurenic acid, 3-hydroxykynurenine (3-HK), and quinolinic acid (QUIN) were determined by validated assays based on liquid chromatography coupled to tandem mass spectrometry. BDNF and irisin serum levels were determined with enzyme-linked immunosorbent assays. BDNF and irisin correlated positively with global cognition and episodic memory, while the neurotoxic metabolite QUIN correlated negatively with executive functions. Stressful life events were associated with reduced BDNF and increased 3-HK. 3-HK decreased after cognitive training, while BDNF tended to increase after physical training. This suggests that psychosocial stress as well as cognitive and physical training may impact BDNF serum levels and the KP. Irisin and QUIN may constitute novel serum biomarkers of cognitive impairment, in addition to BDNF. Larger scale trials are needed to replicate and extend these novel findings.
- Published
- 2017
8. Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers
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Robert Roebling, Peter Reitmeir, Andreas Borta, Laurent Nicolas, Tobias Brand, Klaus Schaffler, and Joachim Scholpp
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0301 basic medicine ,Pharmacology ,Lacosamide ,Visual analogue scale ,business.industry ,Analgesic ,Pregabalin ,Placebo ,Crossover study ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Anesthesia ,Celecoxib ,medicine ,Duloxetine ,Pharmacology (medical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Aims The aim of the present study was to assess the predictivity of laser-(radiant-heat)-evoked potentials (LEPs) from the vertex electroencephalogram, using an algesimetric procedure, testing the anti-nociceptive/anti-hyperalgesic effects of single oral doses of four marketed analgesics (of different compound classes) vs. placebo, in healthy volunteers with three skin types. Methods This was a randomized, placebo-controlled, single-blind, five-way-crossover trial. Twenty-five healthy male/female Caucasians were included (receiving celecoxib 200 mg, pregabalin 150 mg, duloxetine 60 mg, lacosamide 100 mg or placebo) in a Williams design, with CO2 laser-induced painful stimuli to normal, ultraviolet (UV) B-inflamed and capsaicin-irritated skin. LEPs and visual analogue scale ratings were taken at baseline and hourly for 6 h postdose from all three skin types. Results In normal skin, the averaged postdose LEP peak-to-peak-(PtP)-amplitudes were reduced by pregabalin (−2.68 μV; 95% confidence interval (CI) −4.16, 1.19) and duloxetine (−1.73 μV; 95% CI −3.21, −0.26) but not by lacosamide and celecoxib vs. placebo. On UVB-irradiated skin, reflecting inflammatory pain, celecoxib induced a pronounced reduction in LEP PtP amplitudes vs. placebo (−6.2 μV; 95% CI −7.88, −4.51), with a smaller reduction by duloxetine (−4.54 μV; 95% CI −6.21, −2.87) and pregabalin (−3.72 μV; 95% CI −5.40, −2.04), whereas lacosamide was inactive. LEP PtP amplitudes on capsaicin-irritated skin, reflecting peripheral/spinal sensitization, as in neuropathic pain, were reduced by pregabalin (−3.78 μV; 95% CI −5.31, −2.25) and duloxetine (−2.32 μV; 95% CI −3.82, −0.82) but not by celecoxib or lacosamide vs. placebo, which was in agreement with known clinical profiles. Overall, PtP amplitude reductions were in agreement with subjective ratings. Conclusions LEP algesimetry is sensitive to analgesics with different modes of action and may enable the effects of novel analgesics to be assessed during early clinical development.
- Published
- 2017
9. New onset of depression in aging women and men: contributions of social, psychological, behavioral, and somatic predictors in the community
- Author
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Elmar Brähler, Irene Schmidtmann, Ana N. Tibubos, Andreas Schulz, Matthias Michal, Thomas Münzel, Phillipp S Wild, Joerg Wiltink, Andreas Borta, Manfred E. Beutel, Karl J. Lackner, Juliane Burghardt, Norbert Pfeiffer, and Jasmin Ghaemi Kerahrodi
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Male ,Aging ,Health Status ,Social Environment ,03 medical and health sciences ,Social support ,0302 clinical medicine ,Risk Factors ,Germany ,Adaptation, Psychological ,History of depression ,Medicine ,Humans ,Longitudinal Studies ,Correlation of Data ,Social Behavior ,Applied Psychology ,Depression (differential diagnoses) ,Depressive Disorder ,business.industry ,Type D personality ,Incidence ,Panic ,Loneliness ,Anxiety Disorders ,030227 psychiatry ,Patient Health Questionnaire ,Psychiatry and Mental health ,Cross-Sectional Studies ,Anxiety ,Female ,Independent Living ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
BackgroundBased on the vulnerability–stress model, we aimed to (1) determine new onset of depression in individuals who had not shown evidence of depression at baseline (5 years earlier) and (2) identify social, psychological, behavioral, and somatic predictors.MethodsLongitudinal data ofN= 10 036 participants (40–79 years) were evaluated who had no evidence of depression at baseline based on Patient Health Questionnaire (PHQ-9), no history of depression, or intake of antidepressants. Multivariate logistic regression models were used to predict the onset of depression.ResultsPrevalence of new cases of depression was 4.4%. Higher rates of women (5.1%) than men (3.8%) were due to their excess incidence ConclusionsPsychobiological vulnerability, stress, and illness-related factors were predictive of new onset of depression, whereas social support was protective. Baseline subclinical depression was an additional risk weakening the relationship between anxiety and depression by taking their overlap into account. Vulnerability factors differed between men and women.
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- 2018
10. Gray matter networks and clinical progression in subjects with predementia Alzheimer's disease
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Frederik Barkhof, Charlotte E. Teunissen, Sander C.J. Verfaillie, Wiesje M. van der Flier, Mara ten Kate, Philip Scheltens, Andreas Borta, Betty M. Tijms, Alida A. Gouw, Amsterdam Neuroscience - Neurodegeneration, Neurology, NCA - neurodegeneration, Radiology and nuclear medicine, Laboratory Medicine, APH - Personalized Medicine, and APH - Methodology
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0301 basic medicine ,Male ,Risk ,Aging ,medicine.medical_specialty ,Pathology ,Amyloid ,Time Factors ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,Alzheimer Disease ,Internal medicine ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Cognitive decline ,Gray Matter ,Aged ,Proportional Hazards Models ,medicine.diagnostic_test ,Proportional hazards model ,General Neuroscience ,Hazard ratio ,Magnetic resonance imaging ,Organ Size ,Middle Aged ,medicine.disease ,Mental Status and Dementia Tests ,Magnetic Resonance Imaging ,030104 developmental biology ,Cohort ,Cardiology ,Disease Progression ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,030217 neurology & neurosurgery ,Biomarkers ,Developmental Biology - Abstract
We studied whether gray matter network parameters are associated with rate of clinical progression in nondemented subjects who have abnormal amyloid markers in the cerebrospinal fluid (CSF), that is, predementia Alzheimer's disease. Nondemented subjects (62 with subjective cognitive decline; 160 with mild cognitive impairment (MCI); age = 68 ± 8 years; Mini-Mental State Examination (MMSE) = 28 ± 2.4) were selected from the Amsterdam Dementia Cohort when they had abnormal amyloid in CSF (
- Published
- 2018
11. A new dopaminergic nigro-olfactory projection
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Vincent Ries, Günter U. Höglinger, Andreas Borta, Rainer K.W. Schwarting, Ursula Keber, Wolfgang H. Oertel, Dieter Scheller, Miriam Djufri, Oscar Arias-Carrión, Daniel Alvarez-Fischer, and Andrea Windolph
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Male ,drug effects [Olfactory Bulb] ,Olfactory system ,drug effects [Neural Stem Cells] ,Dopamine ,metabolism [Olfaction Disorders] ,metabolism [Neural Stem Cells] ,pathology [Neural Stem Cells] ,drug effects [Neurogenesis] ,pathology [Parkinsonian Disorders] ,Olfaction Disorders ,pathology [Olfactory Bulb] ,chemistry.chemical_compound ,Neural Stem Cells ,Neural Pathways ,pathology [Neurons] ,pharmacology [Thiophenes] ,metabolism [Dopamine] ,Neurons ,metabolism [Olfactory Bulb] ,Dopaminergic ,pathology [Neural Pathways] ,Anatomy ,physiology [Neurogenesis] ,Olfactory Bulb ,Immunohistochemistry ,Substantia Nigra ,Neuroanatomical Tract-Tracing Techniques ,pharmacology [Dopamine Agonists] ,pharmacology [Tetrahydronaphthalenes] ,metabolism [Neurons] ,Dopamine Agonists ,metabolism [Neural Pathways] ,pathology [Olfaction Disorders] ,Oxidopamine ,Tetrahydronaphthalenes ,Neurogenesis ,drug therapy [Olfaction Disorders] ,metabolism [Parkinsonian Disorders] ,Substantia nigra ,Thiophenes ,Olfaction ,Biology ,Pathology and Forensic Medicine ,Cellular and Molecular Neuroscience ,Parkinsonian Disorders ,drug therapy [Parkinsonian Disorders] ,metabolism [Substantia Nigra] ,Animals ,drug effects [Neurons] ,ddc:610 ,Rats, Wistar ,Olfactory memory ,Neuronal Tract-Tracers ,pathology [Substantia Nigra] ,drug effects [Neural Pathways] ,Olfactory tubercle ,rotigotine ,Olfactory bulb ,nervous system ,chemistry ,drug effects [Substantia Nigra] ,Neurology (clinical) ,Neuroscience - Abstract
Parkinson disease (PD) is a neurodegenerative disorder characterized by massive loss of midbrain dopaminergic neurons. Whereas onset of motor impairments reflects a rather advanced stage of the disorder, hyposmia often marks the beginning of the disease. Little is known about the role of the nigro-striatal system in olfaction under physiological conditions and the anatomical basis of hyposmia in PD. Yet, the early occurrence of olfactory dysfunction implies that pathogens such as environmental toxins could incite the disease via the olfactory system. In the present study, we demonstrate a dopaminergic innervation from neurons in the substantia nigra to the olfactory bulb by axonal tracing studies. Injection of two dopaminergic neurotoxins-1-methyl-4-phenylpyridinium and 6-hydroxydopamine-into the olfactory bulb induced a decrease in the number of dopaminergic neurons in the substantia nigra. In turn, ablation of the nigral projection led to impaired olfactory perception. Hyposmia following dopaminergic deafferentation was reversed by treatment with the D1/D2/D3 dopamine receptor agonist rotigotine. Hence, we demonstrate for the first time the existence of a direct dopaminergic projection into the olfactory bulb and identify its origin in the substantia nigra in rats. These observations may provide a neuroanatomical basis for invasion of environmental toxins into the basal ganglia and for hyposmia as frequent symptom in PD.
- Published
- 2015
12. EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects
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Betty M. Tijms, Wiesje M. van der Flier, Alida A. Gouw, Andreas Borta, Astrid M. Alsema, Cornelis J. Stam, Philip Scheltens, Neurology, Amsterdam Neuroscience - Neurodegeneration, APH - Personalized Medicine, APH - Methodology, and Epidemiology and Data Science
- Subjects
0301 basic medicine ,Male ,Aging ,medicine.medical_specialty ,Pathology ,Amyloid ,Amyloid beta ,Brain activity and meditation ,Electroencephalography ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Internal medicine ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,Cognitive decline ,Aged ,Proportional Hazards Models ,Amyloid beta-Peptides ,biology ,medicine.diagnostic_test ,Proportional hazards model ,General Neuroscience ,Middle Aged ,medicine.disease ,Prognosis ,030104 developmental biology ,Early Diagnosis ,biology.protein ,Cardiology ,Disease Progression ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Alzheimer's disease ,Psychology ,030217 neurology & neurosurgery ,Biomarkers ,Developmental Biology - Abstract
We studied whether electroencephalography (EEG)-derived measures of brain oscillatory activity are related to clinical progression in nondemented, amyloid positive subjects. We included 205 nondemented amyloid positive subjects (63 subjective cognitive decline [SCD]; 142 mild cognitive impairment [MCI]) with a baseline resting-state EEG data and ≥1-year follow-up. Peak frequency and relative power of 4 frequency bands were calculated. Relationships between normalized EEG measures and time to clinical progression (conversion from SCD to MCI/dementia or from MCI to dementia) were analyzed using Cox proportional hazard models. One hundred eight (53%) subjects clinically progressed after 2.1 (IQR 1.3–3.0) years. In the total sample, none of the EEG spectral measures were significant predictors. Stratified for baseline diagnosis, we found that in SCD patients higher delta and theta power (HR [95% CI] = 1.7 [1.0–2.7] resp. 2.3 [1.2–4.4]), and lower alpha power and peak frequency (HR [95% CI] = 0.5 [0.3–1.0] resp. 0.6 [0.4–1.0]) were associated with clinical progression over time. In amyloid positive subjects with normal cognition, slowing of oscillatory brain activity is related to clinical progression.
- Published
- 2017
13. Investigation of the predictive validity of laser-EPs in normal, UVB-inflamed and capsaicin-irritated skin with four analgesic compounds in healthy volunteers
- Author
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Klaus, Schaffler, Laurent B, Nicolas, Andreas, Borta, Tobias, Brand, Peter, Reitmeir, Robert, Roebling, and Joachim, Scholpp
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Adult ,Male ,Analgesics ,Cross-Over Studies ,Ultraviolet Rays ,Lasers ,Administration, Oral ,Pain ,Electroencephalography ,Middle Aged ,Dermatitis, Contact ,Healthy Volunteers ,Placebos ,Young Adult ,Treatment Outcome ,Pharmacodynamics ,Hyperalgesia ,Evoked Potentials, Somatosensory ,Humans ,Female ,Single-Blind Method ,Capsaicin ,Pain Measurement ,Skin - Abstract
The aim of the present study was to assess the predictivity of laser-(radiant-heat)-evoked potentials (LEPs) from the vertex electroencephalogram, using an algesimetric procedure, testing the anti-nociceptive/anti-hyperalgesic effects of single oral doses of four marketed analgesics (of different compound classes) vs. placebo, in healthy volunteers with three skin types.This was a randomized, placebo-controlled, single-blind, five-way-crossover trial. Twenty-five healthy male/female Caucasians were included (receiving celecoxib 200 mg, pregabalin 150 mg, duloxetine 60 mg, lacosamide 100 mg or placebo) in a Williams design, with COIn normal skin, the averaged postdose LEP peak-to-peak-(PtP)-amplitudes were reduced by pregabalin (-2.68 μV; 95% confidence interval (CI) -4.16, 1.19) and duloxetine (-1.73 μV; 95% CI -3.21, -0.26) but not by lacosamide and celecoxib vs. placebo. On UVB-irradiated skin, reflecting inflammatory pain, celecoxib induced a pronounced reduction in LEP PtP amplitudes vs. placebo (-6.2 μV; 95% CI -7.88, -4.51), with a smaller reduction by duloxetine (-4.54 μV; 95% CI -6.21, -2.87) and pregabalin (-3.72 μV; 95% CI -5.40, -2.04), whereas lacosamide was inactive. LEP PtP amplitudes on capsaicin-irritated skin, reflecting peripheral/spinal sensitization, as in neuropathic pain, were reduced by pregabalin (-3.78 μV; 95% CI -5.31, -2.25) and duloxetine (-2.32 μV; 95% CI -3.82, -0.82) but not by celecoxib or lacosamide vs. placebo, which was in agreement with known clinical profiles. Overall, PtP amplitude reductions were in agreement with subjective ratings.LEP algesimetry is sensitive to analgesics with different modes of action and may enable the effects of novel analgesics to be assessed during early clinical development.
- Published
- 2016
14. New onset of depression in aging women and men: contributions of social, psychological, behavioral, and somatic predictors in the community – CORRIGENDUM
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Manfred E. Beutel, Elmar Brähler, Joerg Wiltink, Jasmin Ghaemi Kerahrodi, Juliane Burghardt, Matthias Michal, Andreas Schulz, Phillipp S. Wild, Thomas Münzel, Irene Schmidtmann, Karl J. Lackner, Norbert Pfeiffer, Andreas Borta, and Ana N. Tibubos
- Subjects
Psychiatry and Mental health ,Applied Psychology - Published
- 2018
15. P3‐283: Pharmacokinetics, pharmacodynamics, and safety of the novel bace inhibitor bi1181181 after oral administration of single ascending doses in healthy subjects
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Oliver Kleiner, Klaus-Peter Kammerer, Jennifer Schaible, Joachim Scholpp, Laurent Nicolas, Andreas Borta, Jana Podhorna, and Jasmin Link
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Epidemiology ,business.industry ,Health Policy ,Healthy subjects ,Pharmacology ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Pharmacokinetics ,Oral administration ,Pharmacodynamics ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2015
16. P1‐295: Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple‐rising doses of bi409306 film‐coated tablets given orally once‐ or twice‐daily for 14 days in young and elderly healthy volunteers
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Viktoria Moschetti, Heike Zimdahl-Gelling, Michael Sand, Wolfgang Timmer, Andreas Borta, Katja Boland, and Anja Hoch
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Epidemiology ,business.industry ,Health Policy ,Safety tolerability ,Pharmacology ,Coated tablets ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Pharmacokinetics ,Healthy volunteers ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2015
17. P3‐282: Single oral doses of the novel bace inhibitor bi 1181181 significantly reduce concentrations of cerebrospinal fluid amyloid‐beta peptides in healthy subjects
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Joachim Scholpp, Kerstin Pietzko, Jana Podhorna, Laurent Nicolas, Oliver Kleiner, Andreas Borta, Cornelia Dorner-Ciossek, Klaus-Peter Kammerer, and Jennifer Schaible
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medicine.medical_specialty ,biology ,Epidemiology ,Amyloid beta ,business.industry ,Health Policy ,Healthy subjects ,Pharmacology ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Cerebrospinal fluid ,Endocrinology ,Developmental Neuroscience ,Internal medicine ,biology.protein ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business - Published
- 2015
18. Post-trial treatment with the nicotinic agonist metanicotine: Differential effects in Wistar rats with high versus low rearing activity
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Rainer K.W. Schwarting and Andreas Borta
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Male ,Agonist ,Nicotine ,medicine.medical_specialty ,medicine.drug_class ,Clinical Biochemistry ,Individuality ,Anxiety ,Motor Activity ,Toxicology ,Biochemistry ,Open field ,Behavioral Neuroscience ,chemistry.chemical_compound ,Memory ,Internal medicine ,Avoidance Learning ,medicine ,Animals ,Nicotinic Agonists ,Rats, Wistar ,Neurotransmitter ,Biological Psychiatry ,Pharmacology ,Electroshock ,Behavior, Animal ,Dose-Response Relationship, Drug ,Dopaminergic ,Rats ,Endocrinology ,Nicotinic agonist ,chemistry ,Cholinergic ,Psychology ,Acetylcholine ,medicine.drug - Abstract
Laboratory rats, although identical in strain, sex, age and housing conditions, can differ considerably in behavior and physiology. When screened in an open-field, for example, Wistar rats can be assigned to subgroups, based on the measure of rearing activity (high, low rearing activity; HRA/LRA). Such rats have previously been found to differ in dopaminergic and cholinergic brain mechanisms, reactivity to cholinergic drugs, and in tests of learning and memory. Here, we asked whether HRA and LRA rats might respond differently to nicotinic treatment, when given during the consolidation of an aversive experience. Therefore, we tested them for performance in an inhibitory avoidance task where they received post-trial injections of either saline, or the nicotinic agonist metanicotine (RJR-2403, 0.017-1.7 mg/kg, i.p.). In support of previous findings, saline-treated LRA rats showed a trend for higher step-in latencies than HRA rats after shock experience. Furthermore, metanicotine was effective only in LRA rats: Compared to their respective saline-treated controls, the retention scores of LRA rats were decreased after post-trial treatment with the highest dose (1.7 mg/kg). Thus, the nicotinic agonist had an amnestic-like effect dependent on dose and subject-dependent factors (HRA/LRA). These findings are discussed with respect to possible drug actions on mnestic and non-mnestic mechanisms, and the importance of taking subject-dependent variability into account when analysing drug effects.
- Published
- 2005
19. New insights into the relationship of neurogenesis and affect: tickling induces hippocampal cell proliferation in rats emitting appetitive 50-kHz ultrasonic vocalizations
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Rainer K.W. Schwarting, Andreas Borta, Günter U. Höglinger, M. Kehl, Markus Wöhr, and A. Schänzer
- Subjects
Male ,Neurogenesis ,Central nervous system ,Models, Neurological ,Subventricular zone ,Hippocampus ,Affect (psychology) ,Subgranular zone ,Physical Stimulation ,otorhinolaryngologic diseases ,medicine ,Animals ,Ultrasonics ,Rats, Wistar ,Stem Cell Niche ,Cell Proliferation ,Appetitive Behavior ,Behavior, Animal ,General Neuroscience ,Dentate gyrus ,Tickling ,Rats ,Affect ,medicine.anatomical_structure ,Touch ,Dentate Gyrus ,Vocalization, Animal ,Psychology ,Neuroscience - Abstract
Adult hippocampal cell proliferation (HCP) has been associated with psychopathology, especially depression. However, it is controversial whether a constitutively low rate of HCP is a trait predisposing an individual to psychopathology or whether HCP varies with the subject's affective state. We made use of a so-far neglected measure of affect, namely ultrasonic vocalizations, to gain new insights into the relationship of HCP and affect. Rats emit distinct types of ultrasonic vocalizations, which serve as situation-dependent affective signals. In appetitive situations, rats produce 50-kHz-calls, whereas 22-kHz-calls occur in aversive situations. We applied a standardized protocol of repeated tickling and assessed tickling-induced ultrasonic vocalizations as an index of the animals affect. Stereological quantifications of 5-bromo-2'-deoxyuridine (BrdU) and proliferating-cells-nuclear-antigen (PCNA) immunolabeled cells were used to estimate the rate of cell proliferation in the subventricular zone and the subgranular zone of the dentate gyrus in the hippocampus. The rate of cell proliferation was compared between the groups of tickled vs. non-tickled rats and between subgroups of tickled rats defined by the effect of tickling on ultrasonic vocalizations. Tickling induced ultrasonic vocalizations in a subject-dependent manner. HCP correlated positively with appetitive 50-kHz-calls, but negatively with aversive 22-kHz-calls in individual animals, while cell proliferation in the subventricular zone was not associated with the emission of ultrasonic vocalizations. Repeated tickling did not change HCP in all rats, but increased HCP in the subgroup of rats, which experienced this procedure as appetitive, i.e. in rats emitting high numbers of 50-kHz-calls or low numbers of 22-kHz-calls. Together, these data indicate that the effect of tickling on HCP depends on an interaction between a predisposing trait and stimulation-dependent variations of the subject's affective state.
- Published
- 2009
20. Dopamine and adult neurogenesis
- Author
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Günter U. Höglinger and Andreas Borta
- Subjects
medicine.medical_specialty ,Parkinson's disease ,Dopamine ,Subventricular zone ,Substantia nigra ,Biochemistry ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Internal medicine ,Neuroplasticity ,medicine ,Animals ,Humans ,Neurotransmitter ,Cell Proliferation ,Neurons ,Neuronal Plasticity ,Stem Cells ,Dopaminergic ,Neurogenesis ,Brain ,Cell Differentiation ,Parkinson Disease ,medicine.disease ,Nerve Regeneration ,Substantia Nigra ,medicine.anatomical_structure ,Endocrinology ,nervous system ,chemistry ,Psychology ,Neuroscience ,medicine.drug - Abstract
Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease?
- Published
- 2006
21. Rat ultrasonic vocalization in aversively motivated situations and the role of individual differences in anxiety-related behavior
- Author
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Rainer K.W. Schwarting, Markus Wöhr, and Andreas Borta
- Subjects
Male ,Elevated plus maze ,medicine.medical_specialty ,Time Factors ,Adult male ,Individuality ,Audiology ,Anxiety ,Developmental psychology ,Behavioral Neuroscience ,Conditioning, Psychological ,medicine ,Animals ,Ultrasonics ,Fear conditioning ,Rats, Wistar ,Freezing Reaction, Cataleptic ,Maze Learning ,Pain Measurement ,Analysis of Variance ,Motivation ,Behavior, Animal ,Fear ,Rats ,Freezing behavior ,Test day ,Conditioning ,Analysis of variance ,medicine.symptom ,Vocalization, Animal ,Psychology - Abstract
Our previous work has shown that male Wistar rats, although identical in breeder, age and housing conditions, can differ systematically in their anxiety-related behavior as measured in the elevated plus-maze. Since such individual dispositions can affect the responsiveness in other aversively motivated situations, we asked in a 1st experiment whether such rats might also differ in a test of conditioned fear. Based on their levels of spontaneous open arm avoidance in the elevated plus-maze, 20 adult male Wistar rats were divided into those with "high open arm" (HOA) versus "low open arm" (LOA) time. These rats were then tested in a standard fear conditioning paradigm. During the conditioning procedure, they received 6 tone (3 kHz, 20 s) and shock (0.5 mA, 0.5 s) pairings, each followed by a 60 s inter-stimulus interval. Conditioned responses to the tone were tested 24 h thereafter. During both days, freezing behavior and ultrasonic vocalization were measured. Differences in ultrasonic vocalization between HOA and LOA rats were detected during the conditioning day, where vocalization was more likely in LOA rats. Furthermore, LOA rats emitted calls with higher frequency components than HOA rats. On the subsequent day of testing, the number of animals vocalizing, and the rate of vocalization was decreased, and call differences between groups were no longer detectable. In freezing, differences between HOA and LOA rats were observed on the conditioning day, where LOA rats showed more freezing behavior during the tone/shock intervals. Also, on the test day, they showed more freezing behavior during the tone intervals compared to HOA rats. These results indicate that acute and conditioned responses of rats in a conventional fear conditioning paradigm can depend on individual dispositions of anxiety-related behavior as measured with the elevated plus-maze. In a 2nd experiment, we asked whether exposure to an elevated plus-maze would lead to ultrasonic vocalization, which we tested in rats which had been handled or non-handled prior to testing. Most importantly, we found that none of the animals displayed any vocalization in the plus-maze, neither during a 1st nor a repeated test 1 day later. These data are discussed with respect to the presumed role of ultrasonic vocalization in aversively motivated situations, and the mechanisms, which may account for the behavioral differences between HOA and LOA rats in such tests.
- Published
- 2005
22. Inhibitory avoidance, pain reactivity, and plus-maze behavior in Wistar rats with high versus low rearing activity
- Author
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Andreas Borta and Rainer K.W. Schwarting
- Subjects
Male ,Pain Threshold ,Elevated plus maze ,medicine.medical_specialty ,Population ,Conditioning, Classical ,Experimental and Cognitive Psychology ,Context (language use) ,Motor Activity ,Open field ,Arousal ,Developmental psychology ,Behavioral Neuroscience ,Basal (phylogenetics) ,Species Specificity ,Internal medicine ,Threshold of pain ,medicine ,Avoidance Learning ,Reaction Time ,Animals ,Rats, Wistar ,education ,Maze Learning ,education.field_of_study ,Fear ,Behavioral activation ,Rats ,Inhibition, Psychological ,Endocrinology ,Exploratory Behavior ,Psychology - Abstract
Substantial work has shown that rats although identical in strain, sex, age and housing conditions can differ considerably in terms of behavior and physiology. Such individual differences can be rather stable and may be detected by behavioral screening tests. Here, the degree of behavioral activation in a novel open-field situation has been shown to serve as a useful predictor to classify animals of a given population into sub-groups with high or low activity, based on measures like locomotion or rearing activity. We used such a screening test and assigned larger samples of male adult Wistar rats into those with high versus low rearing activity (HRA/LRA). They were then tested in the elevated plus-maze, in an inhibitory avoidance task, and in two tests of pain reactivity (hot-plate, tail-flick). In the open field, HRA rats not only showed more rearing behavior, but also more locomotor activity than LRA rats. In the plus-maze, HRA rats again showed more rearing behavior. Also, they spent less time in the open arms, and entered the closed arm more often than low responder rats, which is indicative of more anxiety-related behavior than in LRA rats. In the inhibitory avoidance test, HRA and LRA rats showed similar basal step-in latencies, whereas HRA rats had shorter retention scores than LRA rats after experience of footshock, especially when using a higher (0.5 mA) shock intensity. In contrast, repeated exposure to the avoidance apparatus without shock did not affect step-in latencies in either group. In the pain test, HRA and LRA rats behaved similarly, indicating that their differences in inhibitory avoidance behavior were probably not determined on the level of pain processing. The relevance of these findings is discussed in the context of previous work, especially with respect to the role of processing of aversive experiences.
- Published
- 2004
23. Analysis of behavioral asymmetries in the elevated plus-maze and in the T-maze
- Author
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Rainer K.W. Schwarting and Andreas Borta
- Subjects
Male ,Elevated plus maze ,medicine.medical_specialty ,Time Factors ,N-Methyl-3,4-methylenedioxyamphetamine ,Audiology ,Affect (psychology) ,Functional Laterality ,Developmental psychology ,Serotonin Agents ,medicine ,Reaction Time ,Animals ,Alternation (linguistics) ,Rats, Wistar ,Amphetamine ,Maze Learning ,Analysis of Variance ,Behavior, Animal ,Dose-Response Relationship, Drug ,General Neuroscience ,MDMA ,T-maze ,Rats ,Space Perception ,Exploratory Behavior ,Anxiety ,Analysis of variance ,medicine.symptom ,Psychology ,medicine.drug - Abstract
When studying functional asymmetries in normal laboratory rats, several behavioral tests have been applied and proven their utility, including turning in rotometers or open-fields, handedness in paw usage, T-maze alternation, and others. Here, we analyzed male Wistar rats in two tests, namely the elevated plus-maze and the T-maze. In these tests, behavioral asymmetries are rather likely to occur, since the animals have to show several types of turns towards the left or right when ambulating through these environments. In a first study using the plus-maze, we provide detailed data on (A) the types of turns which the animals showed when changing their direction within arms (i.e., 180 degrees turns), and (B) the types of turns when proceeding from one arm to an adjacent one (i.e., 90 degrees turns). With respect to asymmetry, we found moderate biases in favor of the right. On the 1st day of plus-maze testing, there was a trend for more rightward turns within arms. On the 2nd day of testing, there was a trend for turns towards the right when alternating between arms of the plus-maze. In a 2nd study, we asked for asymmetries in the plus-maze in animals, which had been treated acutely with the psychostimulatory amphetamine analogue 3,4-methylene-dioxymethamphetamine (MDMA). Psychostimulants drugs, especially amphetamine, have repeatedly been used before in work on functional asymmetry, since they can enhance or reveal asymmetries in normal rats. MDMA had dose-dependent effects on activity, which affected turns within arms, and turns between arms; however, there was only sparse evidence with respect to asymmetry. Interestingly, and if at all, asymmetry was in favor of the right. Finally, we present data for behavior in the T-maze, where we used a spontaneous test version, that is, the animals could explore the maze but had no task to solve. Asymmetries were measured as turns within the start arm (180 degrees), and as left- or rightward turns between arms (90 degrees ) at the T-point of the maze. In both measures, we again obtained evidence for asymmetries in favor of the right. This work supports previous studies showing that the T-maze is suitable to analyze behavioral asymmetries in rats. In addition, it provides new evidence with respect to the elevated plus-maze, indicating that this standard tool of anxiety research may also be useful in research on behavioral asymmetries and their underlying brain mechanisms. Behavioral biases in favor of the right, as shown here, have often been reported before, especially with Wistar rats. Such biases should be taken into account, since they can serve as an approach to study brain/behavior relationships, and since they may affect the outcome of physiological manipulations or behavioral trainings.
- Published
- 2004
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