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This study aimed to widen the knowledge of a recently identified, autosomal-recessive, multiple congenital anomalies syndrome to date observed in only other three children. This is the second report of biallelic mutations in MAPKAPK5 whose impairment during human development has been associated with neurological, cardiac, and facial anomalies combined with fingers and toes malformations. Through the affected patients' genetic and phenotypic features overlap, this report confirms MAPKAPK5 as causative gene and adds unique neurodevelopmental characterization. Moreover, based on the complex congenital genitourinary anomalies reported and MAPKAPK5 literature review, we also propose kidney and external genitalia involvement as a key syndromic feature whose expressivity may be more severe in males.

All'interno di un'opera di sintesi su Origene non può mancare un capitolo dedicato alla sua ricezione, visto l'impatto innegabile benché spesso carsico da lui esercitato sulla cultura dell'Occidente medievale e moderno. Il contributo intende mettere in luce tale presenza, a partire dall'aperta ostilità dei Riformatori, Lutero e Melantone in testa, nei confronti del metodo allegorico tipico dell'Alessandrino e tra i quali tuttavia vi furono eccezioni di rilievo, come ad esempio Bucero, estimatore di Origene. In seguito è trattegiato l'apprezzamento rivolto dagli umanisti, in particolare della cerchia dei Platonici di Firenze, alle ardite proposte teologiche di Origene. Un'ultima sezione mette in luce come la diffusione del pensiero di Origene sia stata resa materialmente possibile grazie al sorgere di imprese di edizione critica e di raccolta editoriale dei testi, sfociate nella prima Opera omnia a cura dell'erudito francese Jacques Merlin. This chapter provides an overview of Origen’s impact in the West at the beginning of the Modern Era. The focus is first on the reception, or better the rejection of Origen and his allegories by the Reformers Luther and Melanchthon. An exception within the Reformation is represented by Bucer, whose attitude towards Origen was rather positive. Next, Renaissance humanists are taken into consideration. Early authors like Palmieri made an evident but hidden use of Origen, while Ficino praised him as a Platonic philosopher. Pico della Mirandola was deeply influenced by Origen and wrote a passionate defence of him. The friar Francesco Giorgi proves that Origen could be interesting also as a Christian witness of the Jewish Cabbala. Finally, the most important editions of Origen’s texts between the end of the fifteenth and the beginning of the sixteenth century are presented, with special attention to the first complete edition by Jacques Merlin.

Background Mobile computing and communication technologies in health services and information (so-called mHealth) have modified the traditional approach in the follow-up of patients with implantable cardiac devices, increased patient engagement and empowerment, reduced healthcare costs and improved patients' outcome. Recent developments in mobile technology, with the introduction of smartphone-compatible devices that can measure various health parameters and transfer automatically generated data, have increased the potential application of remote monitoring and the interest towards mHealth. However, little is known about the patients' interest and expectations of this new technology. Objective The patients' interest in the possibility of receiving data from their implantable cardiac device, clinical and health advice via remote monitoring on their smartphones were investigated. Methods A questionnaire entitled ‘Expectations for future possibility of self-management of device data’ (Likert scale scored) was submitted to 300 consecutive implantable cardiac device outpatients. The questionnaire was focused on collecting patients’ expectations in receiving direct information regarding their implantable cardiac device status (item 1, five questions), their own clinical status (item 2, seven questions) and advice on healthy lifestyle promotion (item 3, nine questions). Patient characteristics associated with greater interest towards mHealth were also investigated. Results Questionnaires were completed by 268 patients (221 men, aged 69 ± 14 years). The Cronbach test reported an alpha value of 0.98 for item 1, 0.94 for item 2 and 0.97 for item 3. Patients declared to be mainly interested in the device interventions (62%) and in severe arrhythmia occurrence (61%), followed by data on heart failure severity (54%) and their performed physical activity (48%). Patients showed very little interest in ECG tracing (37%), but the lowest interest was expressed towards healthy lifestyle promotion advice (Conclusions The patients' interests were mainly directed at receiving information related to technical data of the implantable cardiac device and not to the overall management of the disease, underlying the insufficient awareness of patients towards the key role of self-control health status and the promotion of a healthy lifestyle.

The radical homopolymerization of sodium acrylate in water in the presence of potassium peroxodisulphate as initiator was investigator through the use of conductimetry and dilatometry. The kinetics were monitored while varying either the monomer concentration or temperature. Initial rate and order of reaction were determined with good accuracy in a comparative way. The conductimetric method proved superior in monitoring the reaction progress at temperatures higher than 50°C, allowing the activation energy of the reaction to be determined.

This study analyzes the presence of Homeric quotations in the Origenian apology Against Celsus in order to grasp the different functions they cover. They can be summarized as follows: first, the epic citations are sometimes used by the two opponents just as an ornamental tool which embellishes their prose; second, they serve as a support for an argument proposed; third, they reveal a pure polemic aim. The last paragraph, finally, deals with an example of another way of Homeric reception in a Christian environment, hidden behind the lines of the text: indeed, also the prosopological exegesis, created as a hermeneutical tool in order to better understand the meaning of difficult passages in Homer’s poems, can be taken as another form of the presence of Homer in Origen’s apology.

The polymerization of sodium methacrylate in water was investigated using conductimetry and dilatometry. Conductimetry was shown to be a reliable tool for the determination of the kinetic parameters of the blank polymerization (order of reaction with respect to monomer and initiator, activation energy). The conductimetric investigation of template polymerization of the acrylic monomer onto poly(allylamine) hydrochloride at low monomer concentration indicates that the reaction proceeds by a ‘zip’ mechanism. © 1999 Society of Chemical Industry