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Questo numero monografico ha come oggetto di studio un tema particolarmente ambizioso quanto nevralgico: “Prefigurare il lavoro del futuro. Frammenti etnografici e riflessioni antropologiche tra crisi finanziaria e crisi pandemica”. È anche un tema tra i più dibattuti negli ultimi anni, soprattutto dal punto di vista economico e tecnologico

The research on methods for monitoring sheet metal stamping is benefiting from the increased availability of enabling technologies such as sensors, data mining software, cloud computing, and artificial intelligence. The predictive maintenance policies of tools (punches and dies) can be targeted at monitoring progressive wear or at the detection of sudden failures or anomalies. Early detection of tool failure is the method preferred by the recent literature on data management in sheet metal stamping. However, the stamping of small parts poses challenges due to multiple tools and signals and limited visibility of die wear, requiring management of multiple sensors and data sources. This paper proposes a failure prevention approach for progressive die stamping using global and local force sensors with upper bounds for maximum values to indicate unhealthy conditions. The methodology was tested on millions of small washers made of carbon steel. The stamping process was implemented using a servo-press with a high rate. The press was equipped with eight in-process sensors, including strain gauges, thin foil force sensors, and acoustic sensors. The data of material properties, maintenance reports, statistical process control data, and in-process sensors were collected and stored in a data lake. By combining the in-process sensor acquisition with the corresponding log events and maintenance data in the same time span, it is possible to look for correlations among the variables and build an effective tool health prevention policy.

With the increasing demand for openness, flexibility, and monetization, the Network Function Virtualization (NFV) of mobile network functions has become the embracing factor for most mobile network operators. Early reported field deployments of virtualized Evolved Packet Core (EPC) — the core network (CN) component of 4G LTE and 5G non-standalone mobile networks — reflect this growing trend. To best meet the requirements of power management, load balancing, and fault tolerance in the cloud environment, the need for live migration of these virtualized components cannot be shunned. Virtualization platforms of interest include both Virtual Machines (VMs) and Containers, with the latter option offering more lightweight characteristics. This paper’s first contribution is the proposal of a framework that enables migration of containerised virtual EPC components using an open-source migration solution which does not fully support the mobile network protocol stack yet. The second contribution is an experimental-based comprehensive analysis of live migration in two virtualization technologies — VM and Container — with the additional scrutinization on the container migration approach. The presented experimental comparison accounts for several system parameters and configurations: flavor (image) size, network characteristics, processor hardware architecture model, and the CPU load of the backhaul network components. The comparison reveals that the live migration completion time and also the end-user service interruption time of the virtualized EPC components is reduced approximately by 70% in the container platform when using the proposed framework.

Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of M. tuberculosis (Mtb) have developed resistance against most of the established anti-TB drugs, new therapeutic options are urgently needed. An attractive target for the development of new anti-TB agents is the salicylate synthase MbtI, the first enzyme of the mycobacterial siderophore biochemical machinery, absent in human cells. In this work, a set of analogues of 5-(3-cyanophenyl)furan-2-carboxylic acid (I), the most potent MbtI inhibitor identified to date, was synthesized, characterized, and tested to further elucidate the structural requirements for achieving an efficient MbtI inhibition and potent antitubercular activity. The structure–activity relationships (SAR) discussed herein evidenced the importance of the side chain linked to the phenyl moiety to improve the in vitro antimycobacterial activity. In detail, 1f emerged as the most effective analogue against the pathogen, acting without cytotoxicity issues. To deepen the understanding of its mechanism of action, we established a fluorescence-based screening test to quantify the pathogen infectivity within host cells, using MPI-2 murine cells, a robust surrogate for alveolar macrophages. The set-up of the new assay demonstrates significant potential to accelerate the discovery of new anti-TB drugs.

With the aim of developing bioprocesses for waste valorization and a reduced water footprint, we optimized a two-step fermentation process that employs the oleaginous yeast Cutaneotrichosporon oleaginosus for the production of oil from liquid cheese whey permeate. For the first step, the addition of urea as a cost-effective nitrogen source allowed an increase in yeast biomass production. In the second step, a syrup from candied fruit processing, another food waste supplied as carbon feeding, triggered lipid accumulation. Consequently, yeast lipids were produced at a final concentration and productivity of 38 g/L and 0.57 g/L/h respectively, which are among the highest reported values. Through this strategy, based on the valorization of liquid food wastes (WP and mango syrup) and by recovering not only nutritional compounds but also the water necessary for yeast growth and lipid production, we addressed one of the main goals of the circular economy. In addition, we set up an accurate and fast-flow cytometer method to quantify the lipid content, avoiding the extraction step and the use of solvents. This can represent an analytical improvement to screening lipids in different yeast strains and to monitoring the process at the single-cell level.

In this essay, we intend to analyze the process of accumulation of contemporary capitalism, in which the regime of valorization derive from the notion of “common” a “results of social production that are necessary for social interaction and further production, such as knowledges, languages, information affect, and so forth” (Hardt and Negri, 2009) and from its expropriation. When we deal with the concept of “common,” the reference is made to a heterogeneous category. In this text we refer to two modalities of expression of the “common:” the digital common (section network value) and the common of social reproduction (section social reproduction value or the economy of the interiority and anthropomorphic capital). Regarding the first case study, the concept of “network value” is investigated and defined as a product of individual life in a relational context increasingly controlled and subsumed by the social media and big data industry. Regarding the second, we discuss how the activity of social reproduction of individuals is today central in the process of accumulation of the economy. “Social reproduction” is a useful concept to investigate what we call the “anthropomorphic capital,” that is the capacity by the contemporary labor organizations to capture and make productive the essence of today's life and its complexity. In short, it transpires better and better how all activities are productive, i.e., accumulation generators. We observe the apparent paradox of a generalization of surplus value in the era of the decline of waged employment and with it a tension of capital contemporary to the general mortification of living labor. In fact, we note how capital claims to transform the human being into capital itself, explicitly assuming the whole of human existence as a field from which accumulation can be generated (human being, enterprise or human capital). This is what, at this point, we call anthropomorphic capital or the economy of interiority. In the last section, we report some results of an empirical research “Commonfare-Pie News,” able to underline how life is more and more subsumed to the logic of capitalistic valorization, to the point that today we can speak not only of the subsumption of labor to capital but of a real life subsumption.

Walking remains a highly recommended form of exercise for the management of obesity. Thus, comfortable and adequate shoes represent, together with the prescription of a safe adapted physical activity, an important means to achieve the recommended physical activity target volume. However, the literature on shoes specific for obese individuals is inadequate. The aim of the present study was to compare the performance of shoes specifically designed for subjects with obesity with everyday sneakers during instrumented 6-min walking test and outdoor 30-min ambulation in a group of subjects with obesity using a single wearable device. Twenty-three obese individuals (mean age 58.96 years) were recruited and classified into two groups: deconditioned (n = 13) and non-deconditioned patients (n = 10). Each participant was evaluated with his/her daily sneakers and the day after with shoes specifically designed for people with obesity by means of a questionnaire related to the comfort related to each model of shoes and instrumentally during the i6MWT and an outdoor walking test. The results showed that the specifically designed shoes displayed the higher score as for comfort, in particular in the deconditioned group. During the i6MWT, the distance walked, and step length significantly increased in the deconditioned group when specifically designed shoes were worn; no significant changes were observed in the non-deconditioned individuals. The deconditioned group displayed longer step length during the outdoor 30-min ambulation test. In the non-deconditioned group, the use of specific shoes correlated to better performance in terms of gait speed and cadence. These data, although preliminary, seem to support the hypothesis that shoes specifically conceived and designed for counteracting some of the known functional limitations in subjects with obesity allow for a smoother, more stable and possibly less fatiguing gait schema over time.

The purpose of this retrospective study was to quantify the three-dimensional knee and ankle joint kinematics and kinetics during walking in young participants with different degrees of obesity and to identify the associated effects by stratifying the obese participants according to their BMI. Thirty-two young obese individuals (mean age 30.32 years) and 16 normal-weight age-matched individuals were tested using 3D gait analysis. Analysis of kinematic and kinetic data revealed significant differences in mechanics at knee and ankle joints in all the evaluated planes of movement. Compared to the healthy-weight participants, obese adults demonstrated less knee flexion, greater knee ab-adduction angle during the entire gait cycle and abnormalities at the knee flex-extension moment. At the ankle joint, reduced range of motion was observed together with a lower peak of ankle plantarflexor moment and power during terminal stance. These results provide insight into a potential pathway by which obesity predisposes a healthy adult for increased risk of osteoarthritis.

In this article, basic income (BI) will not be considered as a measure to raise living standards and social well-being. Rather, it will be presented as an indispensable structural policy for achieving a healthier social order governed by a more equitable compromise between capital and labor. Embracing the French Regulation School approach, we maintain that such a compromise is founded on the redistribution of productivity gains. Describing the dynamics of productivity enables a better understanding of the main features and development of contemporary capitalism. In advancing our argument, we focus on the socioeconomic transformation that has overtaken the Fordist paradigm within Western countries and propose the term ‘‘cognitive capitalism’’ to describe the new economic system. We argue that BI can be seen as a viable economic policy able to contrast the instability generated by the present form(s) of accumulation, as it increases productivity through network and learning processes.