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72 544x376 Normal 0 21 false false false Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4 VASCULAR ENDOTHELIAL GROWTH FACTOR IN MALIGNANT AND NON MALIGNANT PROSTATIC TISSUE. ASSOCIATION WITH TUMOR RECURRENCE AT ONE YEAR AFTER PROSTATECTOMY. Background : Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor. Aim : To search for VEFG in prostatic tissue. Material and Methods : This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients. Results: PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p Conclusions : These results would rule out VEGF as a prognostic factor in this series of patients. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

Abalone aquaculture is rapidly developing in Chile although this mollusc does not occur naturally in this country. The red abalone Haliotis rufescens was introduced in 1977 and the ezo abalone Haliotis discus hannai in 1982. After several years of research and development, the industry began in 1992 and Chile is currently the fifth producer of cultured abalone in the world with 304 tons in 2006. Twenty five companies are involved in this Chilean industry, culturing mainly red abalone. Most of the farms in the North include hatcheries and land-based grow-out operations, whereas most of the in-water grow-out facilities are located in the South. All farms in Chile use algae as the main food for growing abalone, but artificial feeds are also used in some land-based operations in the North. The average size of abalone harvested in Chile is 8 cm (100-120 g) after 3-5 y in culture systems. Whole frozen abalone (shell on) is the most important form of this Chilean product (82% in 2006) and the main market is Japan (90.2%). Abalone production has increased at a rate of around 50% per annum over the last 3 y. This development is expected to continue in the next years, fostered by favorable geographic, economic, and environmental conditions as well as an important government support to invest in abalone. A survey among producers revealed that feed availability and quality is currently considered a key issue to further develop this industry in Chile.

Prostate cancer (PC) is the second cause of death by cancer in men in Chile. Its behavior is so variable that it is necessary to search reliable prognostic markers. Vascular Endothelial Growth Factor (VEGF) is one of the most powerful pro-angiogenic factors. There is no agreement on its validity as a diagnostic or prognostic factor.To search for VEFG in prostatic tissue.This study was performed in prostatectomy tissue coming from 41 patients with PC and 39 patients with benign prostatic hyperplasia (BPH). Specimens were studied using immunohistochemical staining for VEGF. The percentage of stained glandular cells per patient was calculated and associated with pathological diagnosis in cancer patients.PC biopsies had a mean of 82% of VEGF (+) stained cells, while BPH had only 1.6% (p0.01). No relationship was found between the percentage of staining and recurrence at one year of follow-up in the case of PC.These results would rule out VEGF as a prognostic factor in this series of patients.