1. One‐year safety and efficacy results of insulin treatment simplification with IDegLira in type 2 diabetes
- Author
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Zoltán J. Taybani, Balázs Bótyik, András Gyimesi, Mónika Katkó, and Tamás Várkonyi
- Subjects
diabetes ,IDegLira ,overtreatment ,simplification ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Introduction This study aimed to investigate the sustained safety and efficacy of insulin treatment simplification with IDegLira in patients with type 2 diabetes and an HbA1c ≤ 7.5% (58 mmol/mol) during a 12‐month follow‐up. Methods Seventy‐two adults with type 2 diabetes and an HbA1c ≤ 7.5% (58 mmol/mol) treated with multiple daily insulin injections (MDI) participated in the trial (age 63.8 ± 9.5 years, HbA1c 6.4 ± 0.7%, [46 ± 8 mmol/mol] body weight 92.95 ± 18.83 kg, total daily insulin dose: 43.21 ± 10.80 units; mean ± SD). Previous insulins were stopped, and once daily IDegLira was started. IDegLira was titrated by the patients to achieve a self‐measured prebreakfast plasma glucose concentration of ≥5 mmol/L to ≤6 mmol/L. Results After 12 months, good glycaemic control was maintained, while body weight decreased significantly. Mean HbA1c changed to 6.2 ± 0.8% (44 ± 9 mmol/mol) (p = .109) and body weight changed by −3.89 kg to 89.06 ± 18.61 kg (p
- Published
- 2023
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