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2. Isomeric states in neutron-rich nuclei around $N = 40$

Author

Wimmer, K., Recchia, F., Lenzi, S. M., Riccetto, S., Davinson, T., Estrade, A., Griffin, C. J., Nishimura, S., Phong, V., Söderström, P. -A., Aktas, O., Al-Aqeel, M., Ando, T., Baba, H., Bae, S., Choi, S., Doornenbal, P., Ha, J., Harkness-Brennan, L., Isobe, T., John, P. R., Kahl, D., Kiss, G., Kojouharov, I., Kurz, N., Labiche, M., Matsui, K., Momiyama, S., Napoli, D. R., Niikura, M., Nita, C., Saito, Y., Sakurai, H., Schaffner, H., Schrock, P., Stahl, C., Sumikama, T., Werner, V., Witt, W., and Woods, P. J.

Subjects
Nuclear Experiment
Abstract

Neutron-rich nuclei in the vicinity of the $N=40$ island of inversion are characterized by shell evolution and exhibit deformed ground states. In several nuclei isomeric states have been observed and attributed to excitations to the intruder neutron $1g_{9/2}$ orbital. In the present study we searched for isomeric states in nuclei around $N=40$, $Z=22$ produced by projectile fragmentation at RIBF. Delayed $\gamma$ rays were detected by the EURICA germanium detector array. High statistics data allowed for an updated decay scheme of $^{60}$V. The lifetime of an isomeric state in $^{64}$V was measured for the first time in the present experiment. A previously unobserved isomeric state was discovered in $^{58}$Sc. The measured lifetime suggests a parity changing transition, originating from an odd number of neutrons in the $1g_{9/2}$ orbital. The nature of the isomeric state in $^{58}$Sc is thus different from isomers in the less exotic V and Sc nuclei., Comment: PRC accepted

Published
2021
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3. Shape changes in the mirror nuclei $^{70}$Kr and $^{70}$Se

Author

Wimmer, K., Korten, W., Doornenbal, P., Arici, T., Aguilera, P., Algora, A., Ando, T., Baba, H., Blank, B., Boso, A., Chen, S., Corsi, A., Davies, P., de Angelis, G., de France, G., Delaroche, J. -P., Doherty, D. T., Gerl, J., Gernhäuser, R., Girod, M., Jenkins, D., Koyama, S., Motobayashi, T., Nagamine, S., Niikura, M., Obertelli, A., Libert, J., Lubos, D., Rodríguez, T. R., Rubio, B., Sahin, E., Saito, T. Y., Sakurai, H., Sinclair, L., Steppenbeck, D., Taniuchi, R., Wadsworth, R., and Zielinska, M.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

We studied the proton-rich $T_z=-1$ nucleus $^{70}$Kr through inelastic scattering at intermediate energies in order to extract the reduced transition probability, $B(E2;\;0^+ \rightarrow 2^+)$. Comparison with the other members of the $A=70$ isospin triplet, $^{70}$Br and $^{70}$Se, studied in the same experiment, shows a $3\sigma$ deviation from the expected linearity of the electromagnetic matrix elements as a function of $T_z$. At present, no established nuclear structure theory can describe this observed deviation quantitatively. This is the first violation of isospin symmetry at this level observed in the transition matrix elements. A heuristic approach may explain the anomaly by a shape change between the mirror nuclei $^{70}$Kr and $^{70}$Se contrary to the model predictions., Comment: accepted PRL

Published
2021
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5. Shape coexistence revealed in the $N=Z$ isotope $^{72}$Kr through inelastic scattering

Author

Wimmer, K., Arici, T., Korten, W., Doornenbal, P., Delaroche, J. -P., Girod, M., Libert, J., Rodríguez, T. R., Aguilera, P., Algora, A., Ando, T., Baba, H., Blank, B., Boso, A., Chen, S., Corsi, A., Davies, P., de Angelis, G., de France, G., Doherty, D. T., Gerl, J., Gernhäuser, R., Goigoux, T., Jenkins, D., Kiss, G., Koyama, S., Motobayashi, T., Nagamine, S., Niikura, M., Nishimura, S., Obertelli, A., Lubos, D., Phong, V. H., Rubio, B., Sahin, E., Saito, T. Y., Sakurai, H., Sinclair, L., Steppenbeck, D., Taniuchi, R., Vaquero, V., Wadsworth, R., Wu, J., and Zielinska, M.

Subjects
Nuclear Experiment
Abstract

The $N=Z=36$ nucleus $^{72}$Kr has been studied by inelastic scattering at intermediate energies. Two targets, $^{9}$Be and $^{197}$Au, were used to extract the nuclear deformation length, $\delta_\text{N}$, and the reduced $E2$ transition probability, $B(E2)$. The previously unknown non-yrast $2^+$ and $4^+$ states as well as a new candidate for the octupole $3^-$ state have been observed in the scattering on the Be target and placed in the level scheme based on $\gamma-\gamma$ coincidences. The second $2^+$ state was also observed in the scattering on the Au target and the $B(E2;\;2^+_2 \rightarrow 0^+_1)$ value could be determined for the first time. Analyzing the results in terms of a two-band mixing model shows clear evidence for a oblate-prolate shape coexistence and can be explained by a shape change from an oblate ground state to prolate deformed yrast band from the first $2^+$ state. This interpretation is corroborated by beyond mean field calculations using the Gogny D1S interaction., Comment: 12 pages, 11 figures, accepted European Physical Journal A

Published
2020
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7. Discovery of $^{68}$Br in secondary reactions of radioactive beams

Author

Wimmer, K., Doornenbal, P., Korten, W., Arici, T., Aguilera, P., Algora, A., Ando, T., Baba, H., Blank, B., Boso, A., Chen, S., Corsi, A., Davies, P., de Angelis, G., de France, G., Doherty, D. T., Gerl, J., Gernhaeuser, R., Jenkins, D., Koyama, S., Motobayashi, T., Nagamine, S., Niikura, M., Obertelli, A., Lubos, D., Rubio, B., Sahin, E., Saito, T. Y., Sakurai, H., Sinclair, L., Steppenbeck, D., Taniuchi, R., Wadsworth, R., and Zielinska, M.

Subjects
Nuclear Experiment
Abstract

The proton-rich isotope 68Br was discovered in secondary fragmentation reactions of fast radioactive beams. Proton-rich secondary beams of 70,71,72Kr and 70Br, produced at the RIKEN Nishina Center and identified by the BigRIPS fragment separator, impinged on a secondary 9Be target. Unambiguous particle identification behind the secondary target was achieved with the ZeroDegree spectrometer. Based on the expected direct production cross sections from neighboring isotopes, the lifetime of the ground or long-lived isomeric state of 68Br was estimated. The results suggest that secondary fragmentation reactions, where relatively few nucleons are removed from the projectile, offer an alternative way to search for new isotopes, as these reactions populate preferentially low-lying states., Comment: Phys. Lett. B accepted

Published
2019
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8. First spectroscopy of 61Ti and the transition to the Island of Inversion at N = 40

Author

Wimmer, K., Recchia, F., Lenzi, S. M., Riccetto, S., Davinson, T., Estrade, A., Griffin, C. J., Nishimura, S., Nowacki, F., Phong, V., Poves, A., Söderström, P. -A., Aktas, O., Al-Aqeel, M., Ando, T., Baba, H., Bae, S., Choi, S., Doornenbal, P., Ha, J., Harkness-Brennan, L., Isobe, T., John, P. R., Kahl, D., Kiss, G., Kojouharov, I., Kurz, N., Labiche, M., Matsui, K., Momiyama, S., Napoli, D. R., Niikura, M., Nita, C., Saito, Y., Sakurai, H., Schaffner, H., Schrock, P., Stahl, C., Sumikama, T., Werner, V., Witt, W., and Woods, P. J.

Subjects
Nuclear Experiment
Abstract

Isomeric states in 59,61Ti have been populated in the projectile fragmentation of a 345 AMeV 238U beam at the Radioactive Isotope Beam Factory. The decay lifetimes and delayed gamma-ray transitions were measured with the EURICA array. Besides the known isomeric state in 59Ti, two isomeric states in 61Ti are observed for the first time. Based on the measured lifetimes, transition multipolarities as well as tentative spins and parities are assigned. Large-scale shell model calculations based on the modified LNPS interaction show that both 59Ti and 61Ti belong to the Island of Inversion at N=40 with ground state configurations dominated by particle-hole excitations to the g_9/2 and d_5/2 orbits., Comment: Phys. Lett. B accepted

Published
2019
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9. Shape coexistence and isospin symmetry in $A=70$ nuclei: Spectroscopy of the $T_z = -1$ nucleus $^{70}$Kr

Author

Wimmer, K., Korten, W., Arici, T., Doornenbal, P., Aguilera, P., Algora, A., Ando, T., Baba, H., Blank, B., Boso, A., Chen, S., Corsi, A., Davies, P., de Angelis, G., de France, G., Doherty, D., Gerl, J., Gernhäuser, R., Jenkins, D., Koyama, S., Motobayashi, T., Nagamine, S., Niikura, M., Obertelli, A., Lubos, D., Rubio, B., Sahin, E., Saito, T., Sakurai, H., Sinclair, L., Steppenbeck, D., Taniuchi, R., Wadsworth, R., and Zielinska, M.

Subjects
Nuclear Experiment
Abstract

Excited states in the $T_z=-1$ nucleus $^{70}$Kr have been populated using inelastic scattering of a radioactive $^{70}$Kr beam as well as one- and two-neutron removal reactions from $^{71,72}$Kr at intermediate beam energies. The level scheme of $^{70}$Kr was constructed from the observed $\gamma$-ray transitions and coincidences. Tentative spin and parity assignments were made based on comparison with the mirror nucleus $^{70}$Se. A second $2^+$ state and a candidate for the corresponding $4^+_2$ state suggest shape coexistence in $^{70}$Kr., Comment: accepted Phys. Lett. B

Published
2018
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11. Significance of PSA Screening in Niigata, Japan: Survey of Actual Status of New Cases of Prostate Cancer

Author

Saito T, Komatsubara S, Hara N, Nishiyama T, Katagiri A, Ishizaki F, Hatano A, Komeyama T, Hanyu S, Terunuma M, Imai T, Go H, Iida H, Kurumada S, Yamaguchi S, Takeda K, Ando T, Hoshii T, Kasahara T, and Tomita Y

Subjects
prostate cancer, psa screening, population-based screening, opportunistic screening, one-year all-case survey, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Toshihiro Saito,1 Shuichi Komatsubara,2 Noboru Hara,3 Tsutomu Nishiyama,3 Akiyoshi Katagiri,4 Fumio Ishizaki,5 Akihiko Hatano,6 Takeshi Komeyama,7 Shugo Hanyu,8 Masahiro Terunuma,9 Tomoyuki Imai,10 Hideto Go,11 Hiroaki Iida,12 Shigenori Kurumada,13 Shunsuke Yamaguchi,4,14 Keisuke Takeda,5,15 Takashi Ando,14,15 Tatsuhiko Hoshii,5 Takashi Kasahara,5 Yoshihiko Tomita5 1Department of Urology, Niigata Cancer Center Hospital, Niigata, Japan; 2Department of Urology, Niigata Minami Hospital, Niigata, Japan; 3Department of Urology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Minamiuonuma, Japan; 4Department of Urology, Niigata Prefectural Central Hospital, Joetsu, Japan; 5Department of Renal and Urinary Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; 6Department of Urology, Niigata Prefectural Shibata Hospital, Shibata, Japan; 7Department of Urology, Nagaoka Red Cross Hospital, Nagaoka, Japan; 8Department of Urology, Kashiwazaki General Hospital and Medical Center, Kashiwazaki, Japan; 9Department of Urology, Nagaoka Chuo General Hospital, Nagaoka, Japan; 10Department of Urology, Niigata City General Hospital, Niigata, Japan; 11Department of Urology, Niigata Saiseikai Sanjo Hospital, Sanjo, Japan; 12Department of Urology, Joetsu General Hospital, Joetsu, Japan; 13Department of Urology, Saiseikai Niigata Hospital, Niigata, Japan; 14Department of Urology, Tachikawa General Hospital, Nagaoka, Japan; 15Department of Urology, Murakami General Hospital, Murakami, JapanCorrespondence: Toshihiro SaitoDepartment of Urology, Niigata Cancer Center Hospital, 2-15-3 Kawagishi-cho, Niigata, 951-8566, JapanTel +81-25-266-5111Fax +81-25-233-3849Email urotoshi@niigata-cc.jpPurpose: This study aims to investigate the utility of prostate-specific antigen (PSA) screening by conducting an all-case survey of newly diagnosed prostate cancer patients at Niigata Prefecture, Japan.Patients and Methods: Depending on whether patients were subjected to screening, information was prospectively collected on all prostate cancer patients newly diagnosed between October 1, 2019, and September 30, 2020, at all institutions in Niigata Prefecture where urologists performing prostate biopsy routinely work and differences in clinical parameters were investigated.Results: PSA was measured in 478 out of 1332 patients (35.8%) as part of a community health screening. The rate of metastatic carcinoma (M1) in all patients was 14.9%. When patients were divided into three categories of population-based screening (community health screening and workplace health screening), opportunistic screening (PSA measurements at complete medical check-ups or on patient request), and testing triggered by clinical symptoms or findings, the proportion of metastatic cancer was 4.5%, 3.7%, and 30.6%, respectively, demonstrating that the number of distant metastases was significantly lesser in all patients who underwent screening.Conclusion: The one-year all-case survey of newly diagnosed prostate cancer patients demonstrated that PSA screening significantly contributed to the early diagnosis of current prostate cancer in Japan.Keywords: prostate cancer, PSA screening, population-based screening, opportunistic screening, one-year all-case survey

Published
2021

13. Level of Attrition from Antiretroviral Therapy Among Human Immune Deficiency Virus-Infected Children: The Cases of Sidama Zone, Southern Ethiopia

Author

Sifr Z, Ando T, Semeon W, Ashami K, and Rike M

Subjects
lost to follow-up, attrition, hiv-infected children, art, and sidama zone, Immunologic diseases. Allergy, RC581-607
Abstract

Zemenu Sifr,1 Telto Ando,1 Wosenyeleh Semeon,1 Muse Rike,1 Kidist Ashami2 1Department of Health Information Technology, Hawassa College of Health Sciences, Hawassa, Ethiopia; 2Harvard Graduate School of Arts and Science, Boston, MA, 02138, USACorrespondence: Zemenu SifrDepartment of Health Information Technology, Hawassa College of Health Sciences, P.O. Box 84, Hawassa, EthiopiaEmail sifrezemenu2020@gmail.comBackground: Human immune deficiency virus (HIV) remains one of the leading causes of infectious disease mortality and morbidity in Sub-Saharan Africa. Although remarkable progress has been made in prevention and treatment of HIV, there is a higher rate of loss to follow-up in HIV-infected children than in adults, once they enter care.Objective: To determine the incidence and identify predictors of loss to follow-up among HIV-infected children on anti-retroviral treatment in Sidama Zone, Ethiopia.Methods: A retrospective cohort study was done among children that were enrolled in ART care in Sidama Zone from September 2014 to August 2018. A total of 143 eligible children were included in this study. A structured checklist was used to extract data from patients’ medical records such as patient intake forms, electronic database, and registers. Data were entered, cleaned, coded, and analyzed by STATA version 12. Cox proportional hazards models were fitted to investigate predictors of loss to follow-up.Results: Of the 143 participants, 76 (53.15%) were female children with a median age of 7 years and interquartile range of 4– 9. The incidence rate was 5 per 100 person-years and the cumulative incidence 12.59%. The median follow-up time was 2.46 years and the total time at risk was 356.06 person-years. Furthermore, 55.56% and 72.22% of those lost to follow-up were within the first and the second years of follow-up, respectively. In multivariable Cox proportional model, only the TB status of the children was significantly associated with loss to follow-up with hazard ratio 3.348 [1.174831, 9.543494] and p-value of 0.024.Conclusion: In this study, TB status of children was the significant determinant of loss to follow-up. However, the overall retention was 87.4% and a substantially higher proportion of loss was observed within the first and second years of follow-up.Keywords: lost to follow-up, attrition, HIV-infected children, ART, Sidama zone

Published
2021

14. Scenario-based Quantile Connectedness of the U.S. Interbank Liquidity Risk Network

Author

Ando, T, Bai, J, Lu, L, Vojtech, CM, Ando, T, Bai, J, Lu, L, and Vojtech, CM

Abstract

We characterize the U.S. interbank liquidity risk network based on a supervisory dataset, using a scenario-based quantile network connectedness approach. In terms of methodology, we consider a quantile vector autoregressive model with unobserved heterogeneity and propose a Bayesian nuclear norm estimation method. A common factor structure is employed to deal with unobserved heterogeneity that may exhibit endogeneity within the network. Then we develop a scenario-based quantile network connectedness framework by accommodating various economic scenarios, through a scenario-based moving average expression of the model where forecast error variance decomposition under a future pre-specified scenario is derived. The methodology is used to study the quantile-dependent liquidity risk network among large U.S. bank holding companies. The estimated quantile liquidity risk network connectedness measures could be useful for bank supervision and financial stability monitoring by providing leading indicators of the system-wide liquidity risk connectedness not only at the median but also at the tails or even under a pre-specified scenario. The measures also help identify systemically important banks and vulnerable banks in the liquidity risk transmission of the U.S. banking system.

Published
2024

18. A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

Author

Gemba, K., Ikeda, G., Yasugi, M., Kurimoto, E., Nakano, K., Moritaka, T., Inoue, K., Miyoshi, S., Hamaguchi, N., Ito, R., Sano, Y., Takata, I., Mitani, A., Nishisaka, T., Shoda, H., Nishida, A., Tamamoto, S., Fujitaka, K., Masuda, T., Miyamoto, S., Hattori, N., Sugimoto, K., Fujii, S., Ueda, Y., Sakugawa, M., Fukamatsu, N., Ogata, Y., Bandoh, S., Kanaji, N., Takigawa, N., Yamane, H., Ochi, N., Honda, Y., Oka, M., Kittaka, M., Kubota, T., Yokoyama, A., Yokoyama, T., Sato, E., Shiota, Y., Horita, N., Kanematsu, T., Awaya, Y., Nakamasu, A., Murakami, I., Kuyama, S., Kudo, K., Tamura, T., Umeno, T., Morichika, D., Fujiwara, K., Sato, K., Harada, D., Nogami, N., Nishii, K., Fuchimoto, Y., Kishimoto, T., Kawai, H., Watanabe, K., Tokumo, K., Isobe, T., Tsubata, Y., Inoue, M., Ichikawa, H., Nishioka, Y., Hanibuchi, M., Goto, H., Sumikawa, T., Kodani, M., Suyama, H., Makino, H., Kinosita, N., Shimizu, E., Obata, H., Ikegami, H., Chikamori, K., Maeda, T., Kishino, T., Kamei, H., Ueoka, H., Kunihiro, Y., Kobayashi, T., Ueda, K., Hayashi, M., Kamiya, M., Murakami, J., Sato, A., Ichihara, E., Kubo, T., Ninomiya, T., Hirata, T., Minami, D., Kato, Y., Higo, H., Makimoto, G., Toyota, Y., Oda, N., Nakanishi, M., Kayatani, H., Senoo, S., Kano, H., Watanabe, H., Ando, T., Nakasuka, T., Hara, N., Itano, J., Nakashima, H., Tabata, M., Ninomiya, Kiichiro, Hata, Tae, Yoshioka, Hiroshige, Ohashi, Kadoaki, Bessho, Akihiro, Hosokawa, Shinobu, Ishikawa, Nobuhisa, Yamasaki, Masahiro, Shibayama, Takuo, Aoe, Keisuke, Kozuki, Toshiyuki, Harita, Shingo, Ueda, Yutaka, Murakami, Toshi, Fujimoto, Nobukazu, Yanai, Hiroyuki, Toyooka, Shinichi, Takata, Minoru, Hotta, Katsuyuki, and Kiura, Katsuyuki

Published
2019
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20. Weak localization in monolayer and bilayer graphene

Author

Kechedzhi, K., McCann, E., Fal'ko, Vladimir I., Suzuura, H., Ando, T., and Altshuler, B. L.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Disordered Systems and Neural Networks
Abstract

We describe the weak localization correction to conductivity in ultra-thin graphene films, taking into account disorder scattering and the influence of trigonal warping of the Fermi surface. A possible manifestation of the chiral nature of electrons in the localization properties is hampered by trigonal warping, resulting in a suppression of the weak anti-localization effect in monolayer graphene and of weak localization in bilayer graphene. Intervalley scattering due to atomically sharp scatterers in a realistic graphene sheet or by edges in a narrow wire tends to restore weak localization resulting in negative magnetoresistance in both materials., Comment: corrected misprints present in the published version

Published
2009

21. A genome-wide association study of anorexia nervosa

Author

Boraska, V, Franklin, CS, Floyd, JAB, Thornton, LM, Huckins, LM, Southam, L, Rayner, NW, Tachmazidou, I, Klump, KL, Treasure, J, Lewis, CM, Schmidt, U, Tozzi, F, Kiezebrink, K, Hebebrand, J, Gorwood, P, Adan, RAH, Kas, MJH, Favaro, A, Santonastaso, P, Fernández-Aranda, F, Gratacos, M, Rybakowski, F, Dmitrzak-Weglarz, M, Kaprio, J, Keski-Rahkonen, A, Raevuori, A, Van Furth, EF, Slof-Op 't Landt, MCT, Hudson, JI, Reichborn-Kjennerud, T, Knudsen, GPS, Monteleone, P, Kaplan, AS, Karwautz, A, Hakonarson, H, Berrettini, WH, Guo, Y, Li, D, Schork, NJ, Komaki, G, Ando, T, Inoko, H, Esko, T, Fischer, K, Männik, K, Metspalu, A, Baker, JH, Cone, RD, Dackor, J, DeSocio, JE, Hilliard, CE, O'Toole, JK, Pantel, J, Szatkiewicz, JP, Taico, C, Zerwas, S, Trace, SE, Davis, OSP, Helder, S, Bühren, K, Burghardt, R, de Zwaan, M, Egberts, K, Ehrlich, S, Herpertz-Dahlmann, B, Herzog, W, Imgart, H, Scherag, A, Scherag, S, Zipfel, S, Boni, C, Ramoz, N, Versini, A, Brandys, MK, Danner, UN, de Kovel, C, Hendriks, J, Koeleman, BPC, Ophoff, RA, Strengman, E, van Elburg, AA, Bruson, A, Clementi, M, Degortes, D, Forzan, M, Tenconi, E, Docampo, E, Escaramís, G, Jiménez-Murcia, S, Lissowska, J, Rajewski, A, Szeszenia-Dabrowska, N, Slopien, A, Hauser, J, Karhunen, L, Meulenbelt, I, Slagboom, PE, Tortorella, A, and Maj, M

Subjects
Anorexia, Mental Health, Serious Mental Illness, Human Genome, Eating Disorders, Clinical Research, Genetics, Aetiology, 2.1 Biological and endogenous factors, Anorexia Nervosa, Asian People, Calcineurin, Carrier Proteins, Case-Control Studies, Cullin Proteins, Female, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Humans, Japan, Male, Meta-Analysis as Topic, Nuclear Proteins, Polymorphism, Single Nucleotide, White People, anorexia nervosa, body mass index, eating disorders, genome-wide association study, GWAS, metabolic, Wellcome Trust Case Control Consortium 3, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.

Published
2014

22. Weak localisation magnetoresistance and valley symmetry in graphene

Author

McCann, E., Kechedzhi, K., Fal'ko, Vladimir I., Suzuura, H., Ando, T., and Altshuler, B. L.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Due to the chiral nature of electrons in a monolayer of graphite (graphene) one can expect weak antilocalisation and a positive weak-field magnetoresistance in it. However, trigonal warping (which breaks p/-p symmetry of the Fermi line in each valley) suppresses antilocalisation, while inter-valley scattering due to atomically sharp scatterers in a realistic graphene sheet or by edges in a narrow wire tends to restore conventional negative magnetoresistance. We show this by evaluating the dependence of the magnetoresistance of graphene on relaxation rates associated with various possible ways of breaking a 'hidden' valley symmetry of the system., Comment: Phys. Rev. Lett. 97, 146805 (2006)

Published
2006
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25. Availability of right femoral vein as a route for tunneled hemodialysis catheterization

Author

Shindo M, Takemae H, Kubo T, Soeno M, Ando T, and Morishita Y

Subjects
tunneled hemodialysis catheter, right femoral vein, primary patency rate, catheter-related problems, Medical technology, R855-855.5
Abstract

Mitsutoshi Shindo,1 Hiroaki Takemae,2 Takafumi Kubo,2 Masatsugu Soeno,2 Tetsuo Ando,2 Yoshiyuki Morishita1 1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan; 2Department of Dialysis and Transplant Surgery, Hidaka Hospital, Gunma, Japan Purpose: This study was performed to investigate the primary patency rate and catheter-related problems associated with use of the femoral vein as a route for tunneled hemodialysis catheterization compared with those of the right internal jugular vein as the first-choice route in patients undergoing maintenance hemodialysis. Patients and methods: Twenty-two patients underwent placement of indwelling tunneled hemodialysis catheters in the right internal jugular vein as the first option for maintenance hemodialysis, and 20 patients underwent placement in the right femoral vein as the second option. The primary patency rate of the catheters and catheter-related problems at 1, 3, 6, and 12 months after placement were investigated. Results: The 1-, 3-, 6-, and 12-month primary patency rates of the tunneled hemodialysis catheters in the right internal jugular vein were 95.5%, 95.5%, 81.3%, and 58.3%. The primary patency rates of the catheters in the right femoral vein were 95.0%, 89.5%, 86.7%, and 66.7%. There were no statistically significant differences in the primary patency rates at 1, 3, 6, and 12 months or in catheter-related problems between the right internal jugular vein and right femoral vein. Conclusion: The primary patency rate and catheter-related problems of indwelling tunneled hemodialysis catheters placed in the right femoral vein were not different from those in the right internal jugular vein in patients undergoing maintenance hemodialysis. These results suggest that the right femoral vein might be a useful option for placement of indwelling tunneled hemodialysis catheters in patients undergoing maintenance hemodialysis. Keywords: tunneled hemodialysis catheter, right femoral vein, primary patency rate, catheter-related problems

Published
2018

26. Acute hepatitis E in a renal transplantation recipient: a case report

Author

Shindo M, Takemae H, Kubo T, Soeno M, Ando T, and Morishita Y

Subjects
Hepatitis E virus, anti-HEV IgA, Recipient, Renal transplantation, Zoonosis, Medicine (General), R5-920
Abstract

Mitsutoshi Shindo,1 Hiroaki Takemae,2 Takafumi Kubo,2 Masatsugu Soeno,2 Tetsuo Ando,2 Yoshiyuki Morishita1 1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan; 2Department of Dialysis and Transplant Surgery, Hidaka Hospital, Gunma, Japan Abstract: Hepatitis E is caused by infection with the hepatitis E virus (HEV). HEV is transmitted orally via HEV-contaminated food or drink. Hepatitis E usually shows mild symptoms and is self-limiting in the general population; however, it may progress to chronic hepatitis in immunosuppressed patients such as recipients of organ transplantation. However, a few cases of acute hepatitis E have been reported in organ transplantation recipients. We herein report a case of acute hepatitis E in a 31-year-old male renal transplant recipient. The patient underwent renal transplantation 2 years ago, and his postoperative course was uneventful without rejection. After complaining of general fatigue and low-grade fever for 1 week, he was referred to and admitted to our hospital. Careful interview revealed that he ate undercooked pork 10 weeks prior. Blood analysis revealed liver dysfunction but was serologically negative for hepatitis A, B and C virus, cytomegalovirus infection and collagen diseases. Immunoglobulin A antibody against hepatitis E virus (HEV-IgA) was also negative at that point. After 2 weeks of admission, HEV-IgA and HEV-RNA were measured again as hepatitis E could not be ruled out due to history of ingestion of undercooked meat that may have been contaminated with HEV. At that time, HEV-IgA and HEV-RNA (genotype 3) were positive. Thus, an acute hepatitis E was diagnosed. His liver function gradually improved to within the normal range, and HEV-IgA and HEV-RNA were negative at 11 weeks after admission. In conclusion, we describe here a case of acute hepatitis E in a renal transplant recipient. Careful interview regarding the possibility of ingestion of HEV-contaminated food and repeated measurements of HEV-IgA were helpful in finalizing a diagnosis. Keywords: hepatitis E virus, anti-HEV IgA, recipient, renal transplantation, zoonosis

Published
2018

33. Deep learning acceleration in 14nm CMOS compatible ReRAM array: device, material and algorithm co-optimization

Author

Gong, N., primary, Rasch, M.J., additional, Seo, S.-C., additional, Gasasira, A., additional, Solomon, P., additional, Bragaglia, V., additional, Consiglio, S., additional, Higuchi, H., additional, Park, C., additional, Brew, K., additional, Jamison, P., additional, Catano, C., additional, Saraf, I., additional, Athena, F.F., additional, Silvestre, C., additional, Liu, X., additional, Khan, B., additional, Jain, N., additional, Mcdermott, S., additional, Johnson, R., additional, Estrada-Raygoza, I., additional, Li, J., additional, Gokmen, T., additional, Li, N., additional, Pujari, R., additional, Carta, F., additional, Miyazoe, H., additional, Frank, M.M., additional, Koty, D., additional, Yang, Q., additional, Clark, R., additional, Tapily, K., additional, Wajda, C., additional, Mosden, A., additional, Shearer, J., additional, Metz, A., additional, Teehan, S., additional, Saulnier, N., additional, Offrein, B. J., additional, Tsunomura, T., additional, Leusink, G., additional, Narayanan, V., additional, and Ando, T., additional

Published
2022
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34. Different mechanisms of the hysteresis of the Atlantic Meridional Overturning Circulation in the modern and glacial climates

Author

Ando, T. and Oka, A.

Abstract

The multiple equilibrium behavior of the Atlantic meridional overturning circulation (AMOC) is related to the mode transition of the AMOC, which played an important role in abrupt glacial climate changes. However, the difference between modern and glacial climates is not well understood. Here, we examined the structure of the multiple equilibria of the AMOC under the modern and glacial climates through hysteresis experiments using an earth system model of intermediate complexity. The glacial AMOC exhibited a shallower AMOC mode but not the off mode, and a narrower range of multiple equilibria than the modern AMOC. This glacial hysteresis behavior occurred associated with a shift of deep water formation due to changes in surface air temperature and sea ice, whereas that of the modern AMOC is attributed to the basin-scale salinity feedback. These features were commonly found in two glacial simulations with different strengths of the AMOC at the Last Glacial Maximum., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Published
2023
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39. Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy

Author

Kodera, N, Noshiro, D, Dora, S, Mori, T, Habchi, J, Blocquel, D, Gruet, A, Dosnon, M, Salladini, E, Bignon, C, Fujioka, Y, Oda, T, Noda, N, Sato, M, Lotti, M, Mizuguchi, M, Longhi, S, Ando, T, Kodera N., Noshiro D., Dora S. K., Mori T., Habchi J., Blocquel D., Gruet A., Dosnon M., Salladini E., Bignon C., Fujioka Y., Oda T., Noda N. N., Sato M., Lotti M., Mizuguchi M., Longhi S., Ando T., Kodera, N, Noshiro, D, Dora, S, Mori, T, Habchi, J, Blocquel, D, Gruet, A, Dosnon, M, Salladini, E, Bignon, C, Fujioka, Y, Oda, T, Noda, N, Sato, M, Lotti, M, Mizuguchi, M, Longhi, S, Ando, T, Kodera N., Noshiro D., Dora S. K., Mori T., Habchi J., Blocquel D., Gruet A., Dosnon M., Salladini E., Bignon C., Fujioka Y., Oda T., Noda N. N., Sato M., Lotti M., Mizuguchi M., Longhi S., and Ando T.

Abstract

Intrinsically disordered proteins (IDPs) are ubiquitous proteins that are disordered entirely or partly and play important roles in diverse biological phenomena. Their structure dynamically samples a multitude of conformational states, thus rendering their structural analysis very difficult. Here we explore the potential of high-speed atomic force microscopy (HS-AFM) for characterizing the structure and dynamics of IDPs. Successive HS-AFM images of an IDP molecule can not only identify constantly folded and constantly disordered regions in the molecule, but can also document disorder-to-order transitions. Moreover, the number of amino acids contained in these disordered regions can be roughly estimated, enabling a semiquantitative, realistic description of the dynamic structure of IDPs.

Published
2021

43. Landauer’s Formula

Author

Ando, T., von Klitzing, Klaus, editor, Wiesendanger, Roland, editor, Ando, T., editor, Arakawa, Y., editor, Furuya, K., editor, Komiyama, S., editor, and Nakashima, H., editor

Published
1998
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48. Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

Author

Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ikeda R, Ando T, Oshita H, Aizawa S, Masuda K, Higuma H, Kanehisa M, Ninomiya T, and Akiyoshi J

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men) using a social stress procedure (Trier Social Stress Test [TSST]) and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary α-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism (G196A).Results: A significant three-way interaction (time [3 levels] × BDNF [Val/Val, Val/Met, Met/Met]; P

Published
2014

49. Evaluation of Visual Function and Macular Morphology After Fovea Sparing Internal Limiting Membrane Peeling for Idiopathic Macular Hole

Author

Yoshida, H, Terashima, H, Ueda, E, Ando, T, Hasebe, H, and Fukuchi, T

Abstract

【目的】特発性黄斑円孔(MH)に対して通常の内境界膜剥離(ILMP)と中心窩温存内境界膜剥離(FSIP)を併用した硝子体手術後の視機能および黄斑形態を後ろ向きに比較，検討すること。【対象と方法】対象は2017年1月から2020年5月に25Gまたは27G硝子体手術を行い，術後少なくとも6ヶ月経過観察されたMH症例26例26眼(ILMP群15眼／FSIP群11眼)である。男性11眼，女性15眼，平均年齢67.8±8.8歳，平均円孔径403.8±145.2µmであった。ILMP群は円孔縁含めて内境界膜(ILM)を全て剥離したのに対してFSIP群は求心性に剥離し円孔周囲約500µmのILMを温存した。術前，術後3ヶ月，6ヶ月における視力(logMAR), および網膜外層の形態と術前，術後6ヶ月の中心網膜感度を比較した。【結果】全症例でMHは初回手術で閉鎖され，視力は両群とも術後有意に改善した(ILMP群: 0.62±0.28→0.14±0.22→0.13±0.26, FSIP群 0.59±0.21→0.19±0.29→0.12±0.30)(各p=0.001, p=0.005)。いずれの時点においても両群間で有意差は認めなかった。中心網膜感度も術後有意に改善した(ILMP群: 21.1±4.0→26.6±4.0dB, FSIP群22.0±1.8→26.2±2.1dB)(各p=0.001, p=0.027)。しかし，両群間に有意差を認めなかった。一方，網膜外層において術後3ヶ月，6ヶ月時点でellipsoid zoneに欠損を認めた症例は，ILMP群(100→93%)に対してFSIP群(64→45%)の方がいずれの時点においても，有意に少なかった(各p=0.022, p=0.021)。【結論】MHに対するFSIPは従来のILMPと同等の治療効果が得られ，かつ網膜外層の修復が早い可能性が示唆された。

Published
2021

50. P-108 A phase II study of weekly paclitaxel in patients with advanced or recurrent esophageal cancer who had previously received docetaxel-containing chemotherapy

Author

Ando, T., primary, Nakashima, K., additional, Yoshita, H., additional, Sakumura, M., additional, Nomura, M., additional, Muto, M., additional, Fujii, H., additional, Horie, Y., additional, Takeda, H., additional, Yoshii, T., additional, Tahara, Y., additional, Katada, C., additional, Yoshimura, K., additional, Ishikawa, H., additional, and Hosokawa, A., additional

Published
2022
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