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2. Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.

Author

Wrensch, Margaret, Andersson, U, Wibom, C, Cederquist, K, Aradottir, S, Borg, A, Armstrong, GN, Shete, S, Lau, CC, Bainbridge, MN, and Claus, EB

Abstract

Although familial susceptibility to glioma is known, the genetic basis for this susceptibility remains unidentified in the majority of glioma-specific families. An alternative approach to identifying such genes is to examine cancer pedigrees, which include

Published
2014

9. Sexual harassment among employees and students at a large Swedish university : who are exposed, to what, by whom and where – a cross-sectional prevalence study

Author

Agardh, Anette, Priebe, Gisela, Emmelin, M., Palmieri, J., Andersson, U., Östergren, P-O, Agardh, Anette, Priebe, Gisela, Emmelin, M., Palmieri, J., Andersson, U., and Östergren, P-O

Abstract

Background: Sexual harassment (SH) in the workplace is prevalent and associated with poor health. Universities are large workplaces with complex formal and informal power relations, which may influence the prevalence of SH. Although employees and students share the university context, few studies on SH have included both groups. The overall aim of the study was to investigate SH among employees and students at a large Swedish public university regarding types of harassment, prevalence in different groups, characteristics of the perpetrators, and the circumstances in which it occurs. Methods: A cross-sectional analysis was performed, based on a web-based survey with 120 items that was sent out to all staff, including PhD students (N = 8,238) and students (N = 30,244) in November 2019. The response rate was 33% for staff and 32% for students. Exposure to SH was defined as having experienced at least one of ten defined SH behaviors during their work or studies. Results: Among women, 24.5% of staff and 26.8% of students reported having been exposed to SH. The corresponding figures were 7.0% and 11.3% for male staff and students and 33.3% and 29.4% for non-binary individuals among staff and students. Unwelcome comments, suggestive looks or gestures, and ‘inadvertent’ brushing or touching were the three most common forms of reported harassment, both among staff and students. Attempted or completed rape had been experienced by 2.1% of female and 0.6% of male students. Male and female perpetrators were reported by about 80% and 15%, respectively, of exposed participants. Among staff most reported events occurred during the everyday operation of the university, while among students the majority of the events took place during social events linked to student life. When exposed to a perpetrator from the same group (staff or students), women reported more often being in a subordinate power position in relation to the perpetrator. Conclusions: The results indicate that sexual ha

Published
2022
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15. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons

Author

Andersson, U., Berger, K., Hogberg, A., Landin-Olsson, M., and Holm, C.

Subjects
Blood pressure -- Care and treatment, Blood cholesterol -- Care and treatment, Rose hips -- Health aspects, Overweight persons -- Food and nutrition, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: In studies performed in mice, rose hip powder has been shown to both prevent and reverse high-fat diet-induced obesity and glucose intolerance as well as reduce plasma levels of cholesterol. The aim of this study was to investigate whether daily intake of rose hip powder over 6 weeks exerts beneficial metabolic effects in obese individuals. SUBJECTS/METHODS: A total of 31 obese individuals with normal or impaired glucose tolerance were enrolled in a randomized, double-blind, cross-over study in which metabolic effects of daily intake of a rose hip powder drink over 6 weeks was compared with a control drink. Body weight, glucose tolerance, blood pressure, blood lipids and markers of inflammation were assessed in the subjects. RESULTS: In comparison with the control drink, 6 weeks of daily consumption of the rose hip drink resulted in a significant reduction of systolic blood pressure (-3.4%;P = 0.021), total plasma cholesterol (-4.9%;P = 0.0018), low-density lipoprotein (LDL) cholesterol (-6.0%;P = 0.012) and LDL/HDL ratio (-6.5%;P = 0.041). The Reynolds risk assessment score for cardiovascular disease was decreased in the rose hip group compared with the control group (-17%;P = 0.007). Body weight, diastolic blood pressure, glucose tolerance, and plasma levels of high-density lipoprotein (HDL) cholesterol, triglycerides, incretins and markers of inflammation did not differ between the two groups. CONCLUSIONS: Daily consumption of 40g of rose hip powder for 6 weeks can significantly reduce cardiovascular risk in obese people through lowering of systolic blood pressure and plasma cholesterol levels. European Journal of Clinical Nutrition (2012) 66, 585-590;doi:10.1038/ejcn.2011.203;published online 14 December 2011 Keywords: cholesterol;blood pressure;glucose tolerance;body weight;inflammation, INTRODUCTION The incidence and prevalence rates of type 2 diabetes mellitus (T2DM) is increasing dramatically all over the world. (1) Current estimates predict that 439 million people worldwide will be [...]

Published
2012
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43. Ferriperbøeite-(Ce), [CaCe3] ?=4[Fe3+Al2Fe2+] ?=4[Si2O7][SiO4]3O(OH)2, a new member of the polysomatic epidote-törnebohmite series from the Nya Bastnäs Fe-Cu-REE deposit, Sweden

Author

Bindi L.[1, Holtstam D.[3], Fantappie G.[1], Andersson U.[4], and Bonazzi P. [1]

Subjects
ferriperbøeite-(Ce), new mineral species, epidote, törnebohmite-(Ce), electron-microprobe analyses, Mössbauer spectrum, infra-red spectrum, crystal structure, polysome, Bastnäs-type deposits, Sweden
Abstract

Not abstract available

Published
2018

49. Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.

Author

Ostrom, QT, Kinnersley, B, Wrensch, MR, Eckel-Passow, JE, Armstrong, G, Rice, T, Chen, Y, Wiencke, JK, McCoy, LS, Hansen, HM, Amos, CI, Bernstein, JL, Claus, EB, Il'yasova, D, Johansen, C, Lachance, DH, Lai, RK, Merrell, RT, Olson, SH, Sadetzki, S, Schildkraut, JM, Shete, S, Rubin, JB, Lathia, JD, Berens, ME, Andersson, U, Rajaraman, P, Chanock, SJ, Linet, MS, Wang, Z, Yeager, M, GliomaScan consortium, Houlston, RS, Jenkins, RB, Melin, B, Bondy, ML, Barnholtz-Sloan, JS, Ostrom, QT, Kinnersley, B, Wrensch, MR, Eckel-Passow, JE, Armstrong, G, Rice, T, Chen, Y, Wiencke, JK, McCoy, LS, Hansen, HM, Amos, CI, Bernstein, JL, Claus, EB, Il'yasova, D, Johansen, C, Lachance, DH, Lai, RK, Merrell, RT, Olson, SH, Sadetzki, S, Schildkraut, JM, Shete, S, Rubin, JB, Lathia, JD, Berens, ME, Andersson, U, Rajaraman, P, Chanock, SJ, Linet, MS, Wang, Z, Yeager, M, GliomaScan consortium, Houlston, RS, Jenkins, RB, Melin, B, Bondy, ML, and Barnholtz-Sloan, JS

Abstract

Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.

Published
2018

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