Search

Your search keyword '"Andersson, Lotta E."' showing total 13 results
Start Over Author "Andersson, Lotta E."
13 results on '"Andersson, Lotta E."'

2. Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase

Author

Andersson, Lotta E., primary, Shcherbina, Liliya, additional, Al-Majdoub, Mahmoud, additional, Vishnu, Neelanjan, additional, Arroyo, Claudia Balderas, additional, Aste Carrara, Jonathan, additional, Wollheim, Claes B., additional, Fex, Malin, additional, Mulder, Hindrik, additional, Wierup, Nils, additional, and Spégel, Peter, additional

Published
2017
Full Text
View/download PDF

5. Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

Author

Andersson, Lotta E., Shcherbina, Liliya, Al-Majdoub, Mahmoud, Vishnu, Neelanjan, Arroyo, Claudia Balderas, Carrara, Jonathan Aste, Wollheim, Claes B., Fex, Malin, Mulder, Hindrik, Wierup, Nils, and Spégel, Peter

Subjects
*GLUCOSE metabolism, *GLUTAMINE metabolism, *ANIMAL experimentation, *BIOCHEMISTRY, *BIOLOGICAL models, *CELL lines, *COMPARATIVE studies, *CYTOLOGICAL techniques, *ENZYME inhibitors, *ENZYME-linked immunosorbent assay, *EPITHELIAL cells, *FLAVONOIDS, *GLUTAMIC acid, *INSULIN, *ISLANDS of Langerhans, *PHENOMENOLOGY, *RESEARCH methodology, *MEDICAL cooperation, *MICE, *MITOCHONDRIA, *OXIDOREDUCTASES, *PEPTIDES, *RATS, *RECTAL medication, *RESEARCH, *GLUCAGON-like peptide 1, *EVALUATION research, *CHEMICAL inhibitors, *PHARMACODYNAMICS
Abstract

Glucagon-like peptide 1 (GLP-1), secreted from intestinal L cells, glucose dependently stimulates insulin secretion from β-cells. This glucose dependence prevents hypoglycemia, rendering GLP-1 analogs a useful and safe treatment modality in type 2 diabetes. Although the amino acid glutamine is a potent elicitor of GLP-1 secretion, the responsible mechanism remains unclear. We investigated how GLP-1 secretion is metabolically coupled in L cells (GLUTag) and in vivo in mice using the insulin-secreting cell line INS-1 832/13 as reference. A membrane-permeable glutamate analog (dimethylglutamate [DMG]), acting downstream of electrogenic transporters, elicited similar alterations in metabolism as glutamine in both cell lines. Both DMG and glutamine alone elicited GLP-1 secretion in GLUTag cells and in vivo, whereas activation of glutamate dehydrogenase (GDH) was required to stimulate insulin secretion from INS-1 832/13 cells. Pharmacological inhibition in vivo of GDH blocked secretion of GLP-1 in response to DMG. In conclusion, our results suggest that nonelectrogenic nutrient uptake and metabolism play an important role in L cell stimulus-secretion coupling. Metabolism of glutamine and related analogs by GDH in the L cell may explain why GLP-1 secretion, but not that of insulin, is activated by these secretagogues in vivo. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

6. Inhibition of the malate–aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

Author

Stamenkovic, Jelena A., primary, Andersson, Lotta E., additional, Adriaenssens, Alice E., additional, Bagge, Annika, additional, Sharoyko, Vladimir V., additional, Gribble, Fiona, additional, Reimann, Frank, additional, Wollheim, Claes B., additional, Mulder, Hindrik, additional, and Spégel, Peter, additional

Published
2015
Full Text
View/download PDF

10. Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity

Author

Malmgren, Siri, primary, Spégel, Peter, additional, Danielsson, Anders P.H., additional, Nagorny, Cecilia L., additional, Andersson, Lotta E., additional, Nitert, Marloes Dekker, additional, Ridderstråle, Martin, additional, Mulder, Hindrik, additional, and Ling, Charlotte, additional

Published
2013
Full Text
View/download PDF

11. Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

Author

Spégel, Peter, primary, Sharoyko, Vladimir V., additional, Goehring, Isabel, additional, Danielsson, Anders P. H., additional, Malmgren, Siri, additional, Nagorny, Cecilia L. F., additional, Andersson, Lotta E., additional, Koeck, Thomas, additional, Sharp, Geoffrey W. G., additional, Straub, Susanne G., additional, Wollheim, Claes B., additional, and Mulder, Hindrik, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results