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Your search keyword '"Anderson-Nelson, Susan"' showing total 6 results
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6 results on '"Anderson-Nelson, Susan"'

1. Autoimmune Disorders and the Eye

Author

Thompson, Lisa, Patrianakos, Thomas, Garcia, James, Wadhwa, Arshia, Yang, Ellen, Thomas, Catherine, Schneider, Robin, Stern, Hudson, Palma, Camille, Hill, Kyle, Barquet, Viviana, Anderson-Nelson, Susan, McMahon, Kenneth, Patel, Umangi, Ghadiali, Quraish, Danek, Dagmara, Larsen, Brian, Wong, Anthony, Dawood, Sherif, Ludington, Maxine, Zhang, George, Garakani, Roya, Dwarakanathan, Surendar, Simotas, Athina, Sangal, Kajal, Phelps, Paul, Ashourian, Taylor, Darwish, Dana, Bamba, Sonya, Zein, Michael, Nichols, Jeffrey, To, Josiah, Sarmiento, Angelo, Chaudhary, Shweta, Breshears, Brett, Nelson, Josh, and Giovingo, Michael

Published
2024
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4. Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration

Author

Chen, Wei, Stambolian, Dwight, Edwards, Albert O., Branham, Kari E., Othman, Mohammad, Jakobsdottir, Johanna, Tosakulwong, Nirubol, Pericak-Vance, Margaret A., Campochiaro, Peter A., Klein, Michael L., Tan, Perciliz L., Conley, Yvette P., Kanda, Atsuhiro, Kopplin, Laura, Li, Yanming, Augustaitis, Katherine J., Karoukis, Athanasios J., Scott, William K., Agarwal, Anita, Kovach, Jaclyn L., Schwartz, Stephen G., Postel, Eric A., Brooks, Matthew, Baratz, Keith H., Brown, William L., Brucker, Alexander J., Orlin, Anton, Brown, Gary, Ho, Allen, Regillo, Carl, Donoso, Larry, Tian, Lifeng, Kaderli, Brian, Hadley, Dexter, Hagstrom, Stephanie A., Peachey, Neal S., Klein, Ronald, Klein, Barbara E. K., Gotoh, Norimoto, Yamashiro, Kenji, Ferris, Frederick, Fagerness, Jesen A., Reynolds, Robyn, Farrer, Lindsay A., Kim, Ivana K., Miller, Joan W., Cortón, Marta, Carracedo, Angel, Sanchez-Salorio, Manuel, Pugh, Elizabeth W., Doheny, Kimberly F., Brion, Maria, DeAngelis, Margaret M., Weeks, Daniel E., Zack, Donald J., Chew, Emily Y., Heckenlively, John R., Yoshimura, Nagahisa, Iyengar, Sudha K., Francis, Peter J., Katsanis, Nicholas, Seddon, Johanna M., Haines, Jonathan L., Gorin, Michael B., Abecasis, Gonçalo R., Swaroop, Anand, Johnson, Robert N., Ai, Everett, McDonald, H. Richard, Stolarczuk, Margaret, Pavan, Peter Reed, Billiris, Karina K., Iyer, Mohan, Menosky, Matthew M., Pautler, Scott E., Millard, Sharon M., Hubbard, Baker, Aaberg, Thomas, DuBois, Lindy, Lyon, Alice, Anderson-Nelson, Susan, Jampol, Lee M., Weinberg, David V., Muñana, Annie, Rozenbajgier, Zuzanna, Orth, David, Cohen, Jack, MacCumber, Matthew, Figliulo, Celeste, Porcz, Liz, Folk, James, Boldt, H. Culver, Russell, Stephen R., Ivins, Rachel, Hinz, Connie J., Barr, Charles C., Bloom, Steve, Jaegers, Ken, Kritchman, Brian, Whittington, Greg, Heier, Jeffrey, Frederick, Albert R., Morley, Michael G., Topping, Trexler, Davis, Heather L., Bressler, Susan B., Bressler, Neil M., Doll, Warren, Trese, Michael, Capone, Antonio, Garretson, Bruce R., Hassan, Tarek S., Ruby, Alan J., Osentoski, Tammy, McCannel, Colin A., Ruszczyk, Margaret J., Grand, Gilbert, Blinder, Kevin, Holekamp, Nancy M., Joseph, Daniel P., Shah, Gaurav, Nobel, Ginny S., Antoszyk, Andrew N., Browning, David J., Stallings, Alison H, Singerman, Lawrence J., Miller, David, Novak, Michael, Pendergast, Scott, Zegarra, Hernando, Schura, Stephanie A., Smith-Brewer, Sheila, Davidorf, Frederick H., Chambers, Robert, Chorich, Louis, Salerno, Jill, Dreyer, Richard F., Ma, Colin, Kopfer, Marcia R., Wilson, David J., Nolte, Susan K., Grunwald, Juan E., Dunaief, Josh, Fine, Stuart L., Maguire, Albert M., Stoltz, Robert A., McRay, Monique N., Fish, Gary Edd, Anand, Rajiv, Spencer, Rand, Arnwine, Jean, Chandra, Suresh R., Altaweel, Michael, Blodi, Barbara, Gottlieb, Justin, Ip, Michael, Nork, T. Michael, Perry-Raymond, Jennie, Maguire, Maureen G., Brightwell-Arnold, Mary, Harkins, Sandra, Peskin, Ellen, Ying, Gui-Shuang, and Kurinij, Natalie

Subjects
Risk, Genotype, Single-nucleotide polymorphism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Macular Degeneration, Polymorphism (computer science), Genetic variation, Humans, Genetic Predisposition to Disease, Allele, Alleles, Genetics, Tissue Inhibitor of Metalloproteinase-3, Multidisciplinary, Case-control study, Chromosome Mapping, Genetic Variation, Biological Sciences, eye diseases, Complement Factor I, ABCA1, Case-Control Studies, biology.protein, Regression Analysis, Lipoproteins, HDL, Genome-Wide Association Study
Abstract

We executed a genome-wide association scan for age-related macular degeneration (AMD) in 2,157 cases and 1,150 controls. Our results validate AMD susceptibility loci near CFH ( P < 10 −75 ), ARMS2 ( P < 10 −59 ), C2/CFB ( P < 10 −20 ), C3 ( P < 10 −9 ), and CFI ( P < 10 −6 ). We compared our top findings with the Tufts/Massachusetts General Hospital genome-wide association study of advanced AMD (821 cases, 1,709 controls) and genotyped 30 promising markers in additional individuals (up to 7,749 cases and 4,625 controls). With these data, we identified a susceptibility locus near TIMP3 (overall P = 1.1 × 10 −11 ), a metalloproteinase involved in degradation of the extracellular matrix and previously implicated in early-onset maculopathy. In addition, our data revealed strong association signals with alleles at two loci ( LIPC , P = 1.3 × 10 −7 ; CETP , P = 7.4 × 10 −7 ) that were previously associated with high-density lipoprotein cholesterol (HDL-c) levels in blood. Consistent with the hypothesis that HDL metabolism is associated with AMD pathogenesis, we also observed association with AMD of HDL-c—associated alleles near LPL ( P = 3.0 × 10 −3 ) and ABCA1 ( P = 5.6 × 10 −4 ). Multilocus analysis including all susceptibility loci showed that 329 of 331 individuals (99%) with the highest-risk genotypes were cases, and 85% of these had advanced AMD. Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies.

Published
2010

6. Choroidal Neovascularization Associated With Choroidal Hemangiomas

Author

Ruby, Alan J., Jampol, Lee M., Goldberg, Morton F., Schroeder, Robert, and Anderson-Nelson, Susan

Abstract

• Two patients with choroidal hemangiomas developed choroidal neovascularization. One patient with Sturge-Weber syndrome, a unilateral diffuse choroidal hemangioma, and a serous detachment of the macula was treated with yellow dye laser photocoagulation in a grid pattern to the tumor before glaucoma filtration surgery. Four years after successful laser treatment, the patient developed subfoveal choroidal neovascularization in an area of treatment. A second patient with a circumscribed choroidal hemangioma developed spontaneous subfoveal choroidal neovascularization 12 years after initial diagnosis of the hemangioma. The development of choroidal neovascularization associated with choroidal hemangiomas represents a potential cause of poor visual outcome in these patients.

Published
1992
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