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4. Successful introgression of wMel Wolbachia into Aedes aegypti populations in Fiji, Vanuatu and Kiribati

Author

Simmons, Cameron P., primary, Donald, Wesley, additional, Tagavi, Lekon, additional, Tarivonda, Len, additional, Quai, Timothy, additional, Tavoa, Raynelyn, additional, Noran, Tebikau, additional, Manikaoti, Erirau, additional, Kareaua, Lavinia, additional, Abwai, Tabomoa Tinte, additional, Chand, Dip, additional, Rama, Vineshwaran, additional, Deo, Vimal, additional, Deo, Kharishma Karti, additional, Tavuii, Aminiasi, additional, Valentine, Wame, additional, Prasad, Raviikash, additional, Seru, Eremasi, additional, Naituku, Leikitah, additional, Ratu, Anaseini, additional, Hesketh, Mark, additional, Kenny, Nichola, additional, Beebe, Sarah C., additional, Goundar, Anjali A., additional, McCaw, Andrew, additional, Buntine, Molly, additional, Green, Ben, additional, Frossard, Tibor, additional, Gilles, Jeremie R. L., additional, Joubert, D. Albert, additional, Wilson, Geoff, additional, Duong, Le Quyen, additional, Bouvier, Jean B, additional, Stanford, Darren, additional, Forder, Carolyn, additional, Duyvestyn, Johanna M., additional, Pacidônio, Etiene C., additional, Flores, Heather A., additional, Wittmeier, Natalie, additional, Retzki, Kate, additional, Ryan, Peter A., additional, Denton, Jai A., additional, Smithyman, Ruth, additional, Tanamas, Stephanie K., additional, Kyrylos, Peter, additional, Dong, Yi, additional, Khalid, Anam, additional, Hodgson, Lauren, additional, Anders, Katherine L., additional, and O’Neill, Scott L., additional

Published
2024
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10. The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants

Author

Thompson, Corinne N., Tu, Le Thi Phuong, Anders, Katherine L., Hieu, Nguyen Trong, Vi, Lu Lan, Chau, Nguyen Van Vinh, Duong, Vu Thuy, Chau, Nguyen Ngoc Minh, Chau, Tran Thi Hong, Tuyen, Ha Thanh, Nga, Tran Vu Thieu, Van Minh, Pham, Nhu, Tran Do Hoang, Nhi, Le Thi Quynh, Saul, Allan, Martin, Laura B., Podda, Audino, Gerke, Christiane, Thwaites, Guy, Simmons, Cameron P., and Baker, Stephen

Published
2016
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11. An economic evaluation of Wolbachia deployments for dengue control in Vietnam.

Author

Turner, Hugo C., Quyen, Duong Le, Dias, Reynold, Huong, Phan Thi, Simmons, Cameron P., and Anders, Katherine L.

Subjects
DENGUE hemorrhagic fever, WOLBACHIA, DENGUE, COST benefit analysis, COST effectiveness, AEDES aegypti
Abstract

Introduction: Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the benefits of such an intervention at a large scale. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control in Vietnam–targeted at the highest burden urban areas. Methods: Ten settings within Vietnam were identified as priority locations for potential future Wolbachia deployments (using a population replacement strategy). The effectiveness of Wolbachia deployments in reducing the incidence of symptomatic dengue cases was assumed to be 75%. We assumed that the intervention would maintain this effectiveness for at least 20 years (but tested this assumption in the sensitivity analysis). A cost-utility analysis and cost-benefit analysis were conducted. Results: From the health sector perspective, the Wolbachia intervention was projected to cost US$420 per disability-adjusted life year (DALY) averted. From the societal perspective, the overall cost-effectiveness ratio was negative, i.e. the economic benefits outweighed the costs. These results are contingent on the long-term effectiveness of Wolbachia releases being sustained for 20 years. However, the intervention was still classed as cost-effective across the majority of the settings when assuming only 10 years of benefits Conclusion: Overall, we found that targeting high burden cities with Wolbachia deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains. Author summary: Dengue is a major public health challenge and a growing problem due to climate change. The release of Aedes aegypti mosquitoes infected with the intracellular bacterium Wolbachia is a novel form of vector control against dengue. However, there remains a need to evaluate the health and economic benefits of such an intervention at a large scale, as well as its value for money. In this paper, we evaluate the potential economic impact and cost-effectiveness of scaled Wolbachia deployments as a form of dengue control in Vietnam–targeted at the highest burden urban areas. Ten settings within Vietnam were identified as priority locations for potential future Wolbachia deployments (using a population replacement strategy). We assumed that the effectiveness of Wolbachia deployments in reducing the incidence of symptomatic dengue cases would be 75%. We found that targeting high burden cities with Wolbachia deployments would be a cost-effective intervention in Vietnam and generate notable broader benefits besides health gains. Overall, this work highlights the value of investment in the scaled implementation of Wolbachia deployments as an effective and cost-effective tool for dengue control in Vietnam, and more generally for addressing the global challenge of dengue control. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Aedes aegypti abundance and insecticide resistance profiles in the Applying Wolbachia to Eliminate Dengue trial

Author

Tantowijoyo, Warsito, primary, Tanamas, Stephanie K., additional, Nurhayati, Indah, additional, Setyawan, Sigit, additional, Budiwati, Nida, additional, Fitriana, Iva, additional, Ernesia, Inggrid, additional, Wardana, Dwi Satria, additional, Supriyati, Endah, additional, Arguni, Eggi, additional, Meitika, Yeti, additional, Prabowo, Equatori, additional, Andari, Bekti, additional, Green, Benjamin R., additional, Hodgson, Lauren, additional, Rancès, Edwige, additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Anders, Katherine L., additional, Ansari, M. Ridwan, additional, Indriani, Citra, additional, Ahmad, Riris Andono, additional, Utarini, Adi, additional, and Simmons, Cameron P., additional

Published
2022
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16. Impact of randomised wmel Wolbachia deployments on notified dengue cases and insecticide fogging for dengue control in Yogyakarta City.

Author

Indriani, Citra, Tanamas, Stephanie K., Khasanah, Uswatun, Ansari, Muhammad Ridwan, Rubangi, Tantowijoyo, Warsito, Ahmad, Riris Andono, Dufault, Suzanne M., Jewell, Nicholas P., Utarini, Adi, Simmons, Cameron P., and Anders, Katherine L.

Subjects
PREVENTION of infectious disease transmission, DENGUE, CHIKUNGUNYA, CONFIDENCE intervals, MOSQUITO vectors, DENGUE hemorrhagic fever, INSECTICIDES, GRAM-negative bacteria, PUBLIC health, REGRESSION analysis, INFECTION control, TREATMENT effectiveness, RESEARCH funding, VIROLOGY, MOSQUITOES, INFECTIOUS disease transmission
Abstract

Releases of Wolbachia (wMel)-infected Aedes aegypti mosquitoes significantly reduced the incidence of virologically confirmed dengue in a previous cluster randomised trial in Yogyakarta City, Indonesia. Following the trial, wMel releases were extended to the untreated control areas, to achieve city-wide coverage of Wolbachia. In this predefined analysis, we evaluated the impact of the wMel deployments in Yogyakarta on dengue hemorrhagic fever (DHF) case notifications and on the frequency of perifocal insecticide spraying by public health teams. Monthly counts of DHF cases notified to the Yogyakarta District Health Office between January 2006 and May 2022 were modelled as a function of time-varying local wMel treatment status (fully- and partially-treated vs untreated, and by quintile of wMel prevalence). The frequency of insecticide fogging in wMel-treated and untreated areas was analysed using negative binomial regression. Notified DHF incidence was 83% lower in fully treated vs untreated periods (IRR 0.17 [95% CI 0.14, 0.20]), and 78% lower in areas with 80–100% wMel prevalence compared to areas with 0–20% wMel (IRR 0.23 [0.17, 0.30]). A similar intervention effect was observed at 60–80% wMel prevalence as at 80–100% prevalence (76% vs 78% efficacy, respectively). Pre-intervention, insecticide fogging occurred at similar frequencies in areas later randomised to wMel-treated and untreated arms of the trial. After wMel deployment, fogging occurred significantly less frequently in treated areas (IRR 0.17 [0.10, 0.30]). Deployments of wMel-infected Aedes aegypti mosquitoes resulted in an 83% reduction in the application of perifocal insecticide spraying, consistent with lower dengue case notifications in wMel-treated areas. These results show that the Wolbachia intervention effect demonstrated previously in a cluster randomised trial was also measurable from routine surveillance data. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Spatiotemporal dynamics of dengue epidemics, southern Vietnam

Author

Cuong, Hoang Quoc, Vu, Nguyen Thanh, Cazelles, Bernard, Boni, Maciej F., Thai, Khoa T.D., Rabaa, Maia A., Quang, Luong Chan, Simmons, Cameron P., Huu, Tran Ngoc, and Anders, Katherine L.

Subjects
Epidemics -- Research -- Vietnam, Dengue -- Analysis -- Statistics, Disease transmission -- Research, Health
Abstract

Dengue is a growing international public health problem for which a licensed vaccine, therapeutic drugs, and effective vector control programs are lacking. The increasing number of cases is associated with [...]

Published
2013
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19. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil

Author

Gesto, João Silveira Moledo, primary, Pinto, Sofia B., additional, Dias, Fernando Braga Stehling, additional, Peixoto, Julia, additional, Costa, Guilherme, additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Anders, Katherine L., additional, Ryan, Peter A., additional, Simmons, Cameron P., additional, O’Neill, Scott L., additional, and Moreira, Luciano Andrade, additional

Published
2021
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20. Effectiveness of Wolbachia-infected mosquito deployments in reducing the incidence of dengue and other Aedes-borne diseases in Niterói, Brazil: A quasi-experimental study

Author

Pinto, Sofia B., primary, Riback, Thais I. S., additional, Sylvestre, Gabriel, additional, Costa, Guilherme, additional, Peixoto, Julia, additional, Dias, Fernando B. S., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Muzzi, Frederico C., additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Smithyman, Ruth, additional, Eppinghaus, Ana, additional, Saraceni, Valeria, additional, Durovni, Betina, additional, Anders, Katherine L., additional, and Moreira, Luciano A., additional

Published
2021
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21. Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue

Author

Utarini, Adi, primary, Indriani, Citra, additional, Ahmad, Riris A., additional, Tantowijoyo, Warsito, additional, Arguni, Eggi, additional, Ansari, M. Ridwan, additional, Supriyati, Endah, additional, Wardana, D. Satria, additional, Meitika, Yeti, additional, Ernesia, Inggrid, additional, Nurhayati, Indah, additional, Prabowo, Equatori, additional, Andari, Bekti, additional, Green, Benjamin R., additional, Hodgson, Lauren, additional, Cutcher, Zoe, additional, Rancès, Edwige, additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Dufault, Suzanne M., additional, Tanamas, Stephanie K., additional, Jewell, Nicholas P., additional, Anders, Katherine L., additional, and Simmons, Cameron P., additional

Published
2021
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22. Large-scale deployment and establishment of Wolbachia into the Aedes aegypti population in Rio de Janeiro, Brazil

Author

Moledo Gesto, João Silveira, primary, Pinto, Sofia, additional, Stehling Dias, Fernando Braga, additional, Peixoto, Julia, additional, Costa, Guilherme, additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Anders, Katherine L., additional, Ryan, Peter A., additional, Simmons, Cameron P., additional, O’Neill, Scott L., additional, and Moreira, Luciano Andrade, additional

Published
2021
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23. Effectiveness ofWolbachia-infected mosquito deployments in reducing the incidence of dengue and otherAedes-borne diseases in Niterói, Brazil: a quasi-experimental study

Author

Pinto, Sofia B., primary, Riback, Thais I. S., additional, Sylvestre, Gabriel, additional, Costa, Guilherme, additional, Peixoto, Julia, additional, Dias, Fernando B. S., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Muzzi, Frederico C., additional, Kutcher, Simon, additional, Montgomery, Jacqui, additional, Green, Benjamin R., additional, Smithyman, Ruth, additional, Eppinghaus, Ana, additional, Saraceni, Valeria, additional, Durovni, Betina, additional, Anders, Katherine L., additional, and Moreira, Luciano A., additional

Published
2021
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24. The impact of large-scale deployment of Wolbachia mosquitoes on dengue and other Aedes-borne diseases in Rio de Janeiro and Niterói, Brazil: study protocol for a controlled interrupted time series analysis using routine disease surveillance data

Author

Durovni, Betina, primary, Saraceni, Valeria, additional, Eppinghaus, Ana, additional, Riback, Thais I.S., additional, Moreira, Luciano A., additional, Jewell, Nicholas P., additional, Dufault, Suzanne M., additional, O'Neill, Scott L., additional, Simmons, Cameron P., additional, Tanamas, Stephanie K., additional, and Anders, Katherine L., additional

Published
2020
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25. The impact of city-wide deployment of Wolbachia-carrying mosquitoes on arboviral disease incidence in Medellín and Bello, Colombia: study protocol for an interrupted time-series analysis and a test-negative design study

Author

Velez, Ivan D., primary, Santacruz, Eduardo, additional, Kutcher, Simon C., additional, Duque, Sandra L., additional, Uribe, Alexander, additional, Barajas, Jovany, additional, Gonzalez, Sandra, additional, Patino, Ana Cristina, additional, Zuluaga, Lina, additional, Martínez, Luis, additional, Muñoz, Estefanía, additional, Mejia, María Camila, additional, Arbelaez, María Patricia, additional, Pulido, Henry, additional, Jewell, Nicholas P., additional, Dufault, Suzanne M, additional, O'Neill, Scott L., additional, Simmons, Cameron P., additional, Anders, Katherine L., additional, and Tanamas, Stephanie K., additional

Published
2020
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26. Reduced dengue incidence following deployments of Wolbachia-infected Aedes aegypti in Yogyakarta, Indonesia: a quasi-experimental trial using controlled interrupted time series analysis

Author

Indriani, Citra, primary, Tantowijoyo, Warsito, additional, Rancès, Edwige, additional, Andari, Bekti, additional, Prabowo, Equatori, additional, Yusdi, Dedik, additional, Ansari, Muhammad Ridwan, additional, Wardana, Dwi Satria, additional, Supriyati, Endah, additional, Nurhayati, Indah, additional, Ernesia, Inggrid, additional, Setyawan, Sigit, additional, Fitriana, Iva, additional, Arguni, Eggi, additional, Amelia, Yudiria, additional, Ahmad, Riris Andono, additional, Jewell, Nicholas P., additional, Dufault, Suzanne M., additional, Ryan, Peter A., additional, Green, Benjamin R., additional, McAdam, Thomas F., additional, O'Neill, Scott L., additional, Tanamas, Stephanie K., additional, Simmons, Cameron P., additional, Anders, Katherine L., additional, and Utarini, Adi, additional

Published
2020
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27. Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia

Author

Ryan, Peter A., primary, Turley, Andrew P., additional, Wilson, Geoff, additional, Hurst, Tim P., additional, Retzki, Kate, additional, Brown-Kenyon, Jack, additional, Hodgson, Lauren, additional, Kenny, Nichola, additional, Cook, Helen, additional, Montgomery, Brian L., additional, Paton, Christopher J., additional, Ritchie, Scott A., additional, Hoffmann, Ary A., additional, Jewell, Nicholas P., additional, Tanamas, Stephanie K., additional, Anders, Katherine L., additional, Simmons, Cameron P., additional, and O’Neill, Scott L., additional

Published
2020
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28. Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses

Author

O'Neill, Scott L, Ryan, Peter A, Turley, Andrew P, Wilson, Geoff, Retzki, Kate, Iturbe-Ormaetxe, Inaki, Dong, Yi, Kenny, Nichola, Paton, Christopher J, Ritchie, Scott A, Brown-Kenyon, Jack, Stanford, Darren, Wittmeier, Natalie, Jewell, Nicholas P, Tanamas, Stephanie K, Anders, Katherine L, and Simmons, Cameron P

Subjects
fungi, parasitic diseases
Abstract

Background: A number of new technologies are under development for the control of mosquito transmitted viruses, such as dengue, chikungunya and Zika that all require the release of modified mosquitoes into the environment. None of these technologies has been able to demonstrate evidence that they can be implemented at a scale beyond small pilots. Here we report the first successful citywide scaled deployment of Wolbachia in the northern Australian city of Townsville. Methods: The wMel strain of Wolbachia was backcrossed into a local Aedes aegypti genotype and mass reared mosquitoes were deployed as eggs using mosquito release containers (MRCs). In initial stages these releases were undertaken by program staff but in later stages this was replaced by direct community release including the development of a school program that saw children undertake releases. Mosquito monitoring was undertaken with Biogents Sentinel (BGS) traps and individual mosquitoes were screened for the presence of Wolbachia with a Taqman qPCR or LAMP diagnostic assay. Dengue case notifications from Queensland Health Communicable Disease Branch were used to track dengue cases in the city before and after release. Results: Wolbachia was successfully established into local Ae. aegypti mosquitoes across 66 km 2 in four stages over 28 months with full community support. A feature of the program was the development of a scaled approach to community engagement. Wolbachia frequencies have remained stable since deployment and to date no local dengue transmission has been confirmed in any area of Townsville after Wolbachia has established, despite local transmission events every year for the prior 13 years and an epidemiological context of increasing imported cases. Conclusion: Deployment of Wolbachia into Ae. aegypti populations can be readily scaled to areas of ~60km 2 quickly and cost effectively and appears in this context to be effective at stopping local dengue transmission.

Published
2019

29. The impact of large-scale deployment of Wolbachia mosquitoes on dengue and other Aedes-borne diseases in Rio de Janeiro and Niterói, Brazil: study protocol for a controlled interrupted time series analysis using routine disease surveillance data

Author

Durovni, Betina, Saraceni, Valeria, Eppinghaus, Ana, Riback, Thais IS, Moreira, Luciano A, Jewell, Nicholas P, Dufault, Suzanne M, O'Neill, Scott L, Simmons, Cameron P, Tanamas, Stephanie K, and Anders, Katherine L

Subjects
parasitic diseases, virus diseases
Abstract

Background: Rio de Janeiro and Niterói are neighbouring cities in southeastern Brazil which experience large dengue epidemics every 2 to 5 years, with >100,000 cases notified in epidemic years. Costs of vector control and direct and indirect costs due to the Aedes-borne diseases dengue, chikungunya and Zika were estimated to total $650 million USD in 2016, but traditional vector control strategies have not been effective in preventing mosquito-borne disease outbreaks. The Wolbachia method is a novel and self-sustaining approach for the biological control of Aedes-borne diseases, in which the transmission potential of Aedes aegypti mosquitoes is reduced by stably transfecting them with the Wolbachia bacterium ( wMel strain). This paper describes a study protocol for evaluating the effect of large-scale non-randomised releases of Wolbachia--infected mosquitoes on the incidence of dengue, Zika and chikungunya in the two cities of Niterói and Rio de Janeiro. This follows a lead-in period since 2014 involving intensive community engagement, regulatory and public approval, entomological surveys, and small-scale pilot releases. Method: The Wolbachia releases during 2017-2019 covered a combined area of 170 km 2 with a resident population of 1.2 million, across Niterói and Rio de Janeiro. Untreated areas with comparable historical dengue profiles and demographic characteristics have been identified a priori as comparative control areas in each city. The proposed pragmatic epidemiological approach combines a controlled interrupted time series analysis of routinely notified suspected and laboratory-confirmed dengue and chikungunya cases, together with monitoring of Aedes-borne disease activity utilising outbreak signals routinely used in public health disease surveillance. Discussion: If the current project is successful, this model for control of mosquito-borne disease through Wolbachia releases can be expanded nationally and regionally.

Published
2019

30. Establishment of wMel Wolbachia in Aedes aegypti mosquitoes and reduction of local dengue transmission in Cairns and surrounding locations in northern Queensland, Australia

Author

Ryan, Peter A., primary, Turley, Andrew P., additional, Wilson, Geoff, additional, Hurst, Tim P., additional, Retzki, Kate, additional, Brown-Kenyon, Jack, additional, Hodgson, Lauren, additional, Kenny, Nichola, additional, Cook, Helen, additional, Montgomery, Brian L., additional, Paton, Christopher J., additional, Ritchie, Scott A., additional, Hoffmann, Ary A., additional, Jewell, Nicholas P., additional, Tanamas, Stephanie K., additional, Anders, Katherine L., additional, Simmons, Cameron P., additional, and O’Neill, Scott L., additional

Published
2019
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31. The impact of large-scale deployment of Wolbachia mosquitoes on arboviral disease incidence in Rio de Janeiro and Niterói, Brazil: study protocol for a controlled interrupted time series analysis using routine disease surveillance data

Author

Durovni, Betina, primary, Saraceni, Valeria, additional, Eppinghaus, Ana, additional, Riback, Thais I.S., additional, Moreira, Luciano A., additional, Jewell, Nicholas P., additional, Dufault, Suzanne M., additional, O'Neill, Scott L., additional, Simmons, Cameron P., additional, Tanamas, Stephanie K., additional, and Anders, Katherine L., additional

Published
2019
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32. The impact of city-wide deployment of Wolbachia-carrying mosquitoes on arboviral disease incidence in Medellín and Bello, Colombia: study protocol for an interrupted time-series analysis and a test-negative design study

Author

Velez, Ivan D., primary, Santacruz, Eduardo, additional, Kutcher, Simon C., additional, Duque, Sandra L., additional, Uribe, Alexander, additional, Barajas, Jovany, additional, Gonzalez, Sandra, additional, Patino, Ana Cristina, additional, Zuluaga, Lina, additional, Martínez, Luis, additional, Mejia, María Camila, additional, Arbelaez, María Patricia, additional, Pulido, Henry, additional, Jewell, Nicholas P., additional, O'Neill, Scott L., additional, Simmons, Cameron P., additional, Anders, Katherine L., additional, and Tanamas, Stephanie K., additional

Published
2019
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34. Baseline Characterization of Dengue Epidemiology in Yogyakarta City, Indonesia, before a Randomized Controlled Trial of Wolbachia for Arboviral Disease Control

Author

Indriani, Citra, primary, Ahmad, Riris A., additional, Wiratama, Bayu S., additional, Arguni, Eggi, additional, Supriyati, Endah, additional, Sasmono, R. Tedjo, additional, Kisworini, Fita Yulia, additional, Ryan, Peter A., additional, O’Neill, Scott L., additional, Simmons, Cameron P., additional, Utarini, Adi, additional, and Anders, Katherine L., additional

Published
2018
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35. Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses

Author

O'Neill, Scott L., primary, Ryan, Peter A., additional, Turley, Andrew P., additional, Wilson, Geoff, additional, Retzki, Kate, additional, Iturbe-Ormaetxe, Inaki, additional, Dong, Yi, additional, Kenny, Nichola, additional, Paton, Christopher J., additional, Ritchie, Scott A., additional, Brown-Kenyon, Jack, additional, Stanford, Darren, additional, Wittmeier, Natalie, additional, Anders, Katherine L., additional, and Simmons, Cameron P., additional

Published
2018
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36. The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study

Author

de Alwis, Ruklanthi, primary, Tu, Le Thi Phuong, additional, Quynh, Nhi Le Thi, additional, Thompson, Corinne N, additional, Anders, Katherine L, additional, Van Thuy, Nguyen Thi, additional, Hieu, Nguyen Trong, additional, Vi, Lu Lan, additional, Chau, Nguyen Van Vinh, additional, Duong, Vu Thuy, additional, Chau, Tran Thi Hong, additional, Tuyen, Ha Thanh, additional, Nga, Tran Vu Thieu, additional, Minh, Pham Van, additional, Tan, Trinh Van, additional, Thu, Trang Nguyen Hoang, additional, Nhu, Tran Do Hoang, additional, Thwaites, Guy E, additional, Simmons, Cameron, additional, and Baker, Stephen, additional

Published
2018
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37. Scaled deployment of Wolbachia to protect the community from Aedes transmitted arboviruses

Author

O'Neill, Scott L., primary, Ryan, Peter A., additional, Turley, Andrew P., additional, Wilson, Geoff, additional, Retzki, Kate, additional, Iturbe-Ormaetxe, Inaki, additional, Dong, Yi, additional, Kenny, Nichola, additional, Paton, Christopher J., additional, Ritchie, Scott A., additional, Brown-Kenyon, Jack, additional, Stanford, Darren, additional, Wittmeier, Natalie, additional, Anders, Katherine L., additional, and Simmons, Cameron P., additional

Published
2018
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38. The AWED trial (Applying Wolbachia to Eliminate Dengue) to assess the efficacy of Wolbachia-infected mosquito deployments to reduce dengue incidence in Yogyakarta, Indonesia: study protocol for a cluster randomised controlled trial

Author

Anders, Katherine L., primary, Indriani, Citra, additional, Ahmad, Riris Andono, additional, Tantowijoyo, Warsito, additional, Arguni, Eggi, additional, Andari, Bekti, additional, Jewell, Nicholas P., additional, Rances, Edwige, additional, O’Neill, Scott L., additional, Simmons, Cameron P., additional, and Utarini, Adi, additional

Published
2018
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39. Cluster-Randomized Test-Negative Design Trials: A Novel and Efficient Method to Assess the Efficacy of Community-Level Dengue Interventions

Author

Anders, Katherine L, primary, Cutcher, Zoe, additional, Kleinschmidt, Immo, additional, Donnelly, Christl A, additional, Ferguson, Neil M, additional, Indriani, Citra, additional, Ryan, Peter A, additional, O’Neill, Scott L, additional, Jewell, Nicholas P, additional, and Simmons, Cameron P, additional

Published
2018
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41. Epidemiological, Serological, and Virological Features of Dengue in Nha Trang City, Vietnam

Author

Quyen, Duong Le, primary, Thanh Le, Nguyen, additional, Van Anh, Cao Thi, additional, Nguyen, Nguyen Binh, additional, Hoang, Dong Van, additional, Montgomery, Jacqui L., additional, Kutcher, Simon C., additional, Hoang Le, Nguyen, additional, Hien, Nguyen Tran, additional, Hue Kien, Duong Thi, additional, Rabaa, Maia, additional, O’Neill, Scott L., additional, Simmons, Cameron P., additional, Anh, Dang Duc, additional, and Anders, Katherine L., additional

Published
2018
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42. Analysis of cluster-randomized test-negative designs: cluster-level methods.

Author

Jewell, Nicholas P, Dufault, Suzanne, Cutcher, Zoe, Simmons, Cameron P, and Anders, Katherine L

Subjects
INFLUENZA vaccines, DESIGN, AEDES aegypti
Abstract

Intervention trials of vector control methods often require community level randomization with appropriate inferential methods. For many interventions, the possibility of confounding due to the effects of health-care seeking behavior on disease ascertainment remains a concern. The test-negative design, a variant of the case-control method, was introduced to mitigate this issue in the assessment of the efficacy of influenza vaccination (measured at an individual level) on influenza infection. Here, we introduce a cluster-randomized test-negative design that includes randomization of the intervention at a group level. We propose several methods for estimation and inference regarding the relative risk (RR). The inferential methods considered are based on the randomization distribution induced by permuting intervention assignment across two sets of randomly selected clusters. The motivating example is a current study of the efficacy of randomized releases of Wolbachia-infected Aedes aegypti mosquitoes to reduce the incidence of dengue in Yogyakarta City, Indonesia. Estimation and inference techniques are assessed through a simulation study. [ABSTRACT FROM AUTHOR]

Published
2019
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43. The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study.

Author

Alwis, Ruklanthi de, Tu, Le Thi Phuong, Quynh, Nhi Le Thi, Thompson, Corinne N, Anders, Katherine L, Thuy, Nguyen Thi Van, Hieu, Nguyen Trong, Vi, Lu Lan, Chau, Nguyen Van Vinh, Duong, Vu Thuy, Chau, Tran Thi Hong, Tuyen, Ha Thanh, Nga, Tran Vu Thieu, Minh, Pham Van, Tan, Trinh Van, Thu, Trang Nguyen Hoang, Nhu, Tran Do Hoang, Thwaites, Guy E, Simmons, Cameron, and Baker, Stephen

Subjects
SALMONELLA diseases, SALMONELLA typhimurium, SALMONELLA enteritidis, IMMUNOGLOBULINS, MATERNALLY acquired immunity
Abstract

Background: Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where NTS disease is highly endemic.Methods: We recruited 503 pregnant mothers and their infants (following delivery) from urban areas in Vietnam and followed infants until they were 1 year old. Exposure to the dominant NTS serovars, Salmonella enterica serovars Typhimurium and Enteritidis, were assessed using lipopolysaccharide (LPS) O antigen-specific antibodies. Antibody dynamics, the role of maternally acquired antibodies, and NTS seroincidence rates were modeled using multivariate linear risk factor models and generalized additive mixed-effect models.Results: Transplacental transfer of NTS LPS-specific maternal antibodies to infants was highly efficient. Waning of transplacentally acquired NTS LPS-specific antibodies at 4 months of age left infants susceptible to Salmonella organisms, after which they began to seroconvert. High seroincidences of S. Typhimurium and S. Enteritidis LPS were observed, and infants born with higher anti-LPS titers had greater plasma bactericidal activity and longer protection from seroconversion.Conclusions: Although Vietnamese infants have extensive exposure to NTS, maternally acquired antibodies appear to play a protective role against NTS infections during early infancy. These findings suggest that prenatal immunization may be an appropriate strategy to protect vulnerable infants from NTS disease. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Impact of randomised wmel Wolbachiadeployments on notified dengue cases and insecticide fogging for dengue control in Yogyakarta City

Author

Indriani, Citra, Tanamas, Stephanie K., Khasanah, Uswatun, Ansari, Muhammad Ridwan, Tantowijoyo, Warsito, Ahmad, Riris Andono, Dufault, Suzanne M., Jewell, Nicholas P., Utarini, Adi, Simmons, Cameron P., and Anders, Katherine L.

Abstract

ABSTRACTBackgroundReleases of Wolbachia (wMel)-infected Aedes aegypti mosquitoes significantly reduced the incidence of virologically confirmed dengue in a previous cluster randomised trial in Yogyakarta City, Indonesia. Following the trial, wMel releases were extended to the untreated control areas, to achieve city-wide coverage of Wolbachia.ObjectiveIn this predefined analysis, we evaluated the impact of the wMel deployments in Yogyakarta on dengue hemorrhagic fever (DHF) case notifications and on the frequency of perifocal insecticide spraying by public health teams.MethodsMonthly counts of DHF cases notified to the Yogyakarta District Health Office between January 2006 and May 2022 were modelled as a function of time-varying local wMel treatment status (fully- and partially-treated vs untreated, and by quintile of wMel prevalence). The frequency of insecticide fogging in wMel-treated and untreated areas was analysed using negative binomial regression.ResultsNotified DHF incidence was 83% lower in fully treated vs untreated periods (IRR 0.17 [95% CI 0.14, 0.20]), and 78% lower in areas with 80–100% wMel prevalence compared to areas with 0–20% wMel (IRR 0.23 [0.17, 0.30]). A similar intervention effect was observed at 60–80% wMel prevalence as at 80–100% prevalence (76% vs 78% efficacy, respectively). Pre-intervention, insecticide fogging occurred at similar frequencies in areas later randomised to wMel-treated and untreated arms of the trial. After wMel deployment, fogging occurred significantly less frequently in treated areas (IRR 0.17 [0.10, 0.30]).ConclusionsDeployments of wMel-infected Aedes aegypti mosquitoes resulted in an 83% reduction in the application of perifocal insecticide spraying, consistent with lower dengue case notifications in wMel-treated areas. These results show that the Wolbachia intervention effect demonstrated previously in a cluster randomised trial was also measurable from routine surveillance data.

Published
2023
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47. The epidemiology and aetiology of diarrhoeal disease in infancy in southern Vietnam: a birth cohort study

Author

Anders, Katherine L., primary, Thompson, Corinne N., additional, Thuy, Nguyen Thi Van, additional, Nguyet, Nguyen Minh, additional, Tu, Le Thi Phuong, additional, Dung, Tran Thi Ngoc, additional, Phat, Voong Vinh, additional, Van, Nguyen Thi Hong, additional, Hieu, Nguyen Trong, additional, Tham, Nguyen Thi Hong, additional, Ha, Phan Thi Thanh, additional, Lien, Le Bich, additional, Chau, Nguyen Van Vinh, additional, Baker, Stephen, additional, and Simmons, Cameron P., additional

Published
2015
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48. The changing epidemiology of dengue in China, 1990-2014: a descriptive analysis of 25 years of nationwide surveillance data

Author

Lai, Shengjie, primary, Huang, Zhuojie, additional, Zhou, Hang, additional, Anders, Katherine L, additional, Perkins, T Alex, additional, Yin, Wenwu, additional, Li, Yu, additional, Mu, Di, additional, Chen, Qiulan, additional, Zhang, Zike, additional, Qiu, Yanzi, additional, Wang, Liping, additional, Zhang, Honglong, additional, Zeng, Linjia, additional, Ren, Xiang, additional, Geng, Mengjie, additional, Li, Zhongjie, additional, Tatem, Andrew J, additional, Hay, Simon I, additional, and Yu, Hongjie, additional

Published
2015
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49. Epidemiology and Virology of Acute Respiratory Infections During the First Year of Life

Author

Anders, Katherine L., primary, Nguyen, Hoa L., additional, Nguyen, Nguyet Minh, additional, Van Thuy, Nguyen Thi, additional, Hong Van, Nguyen Thi, additional, Hieu, Nguyen Trong, additional, Hong Tham, Nguyen Thi, additional, Thanh Ha, Phan Thi, additional, Lien, Le Bich, additional, Vinh Chau, Nguyen Van, additional, Ty Hang, Vu Thi, additional, van Doorn, H. Rogier, additional, and Simmons, Cameron P., additional

Published
2015
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50. Households as Foci for Dengue Transmission in Highly Urban Vietnam

Author

Anders, Katherine L., primary, Nga, Le Hong, additional, Thuy, Nguyen Thi Van, additional, Ngoc, Tran Van, additional, Tam, Cao Thi, additional, Tai, Luong Thi Hue, additional, Truong, Nguyen Thanh, additional, Duyen, Huynh Thi Le, additional, Trung, Vu Tuan, additional, Kien, Duong Thi Hue, additional, Wolbers, Marcel, additional, Wills, Bridget, additional, Chau, Nguyen Van Vinh, additional, Tho, Nguyen Dac, additional, and Simmons, Cameron P., additional

Published
2015
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