1. Non-invasive functional mapping of the human motor cortex using near-infrared spectroscopy
- Author
-
Andeas Thiel, Herta Flor, Werner Mühlnickel, Christina Hirth, Hellmuth Obrig, Johannes Bernarding, Arno Villringer, Ulrich Dirnagl, and Kersten Villringer
- Subjects
Adult ,Brain Mapping ,Spectroscopy, Near-Infrared ,medicine.diagnostic_test ,Chemistry ,General Neuroscience ,Near-infrared spectroscopy ,Non invasive ,Motor Cortex ,Magnetic resonance imaging ,Oxygenation ,Functional mapping ,Functional brain ,Nuclear magnetic resonance ,medicine.anatomical_structure ,medicine ,Humans ,sense organs ,Sensory cortex ,Neuroscience ,Motor cortex - Abstract
We applied non-invasive multisite near-infrared spectroscopy (NIRS) to assess oxygenation changes during performance of a sequential finger opposition task in five healthy human adults. Oxygenation response was localized anatomically using three-dimensional high-resolution magnetic resonance imaging (3D MRI). NIRS measurements showed a localized increase in [oxy-Hb] and a decrease in [deoxy-Hb] in all subjects. The largest response was obtained when the measurement position was over the primary motor and sensory cortex hand area. Interestingly, changes in [deoxy-Hb] seemed to be more localized than changes in [oxy-Hb]. We conclude that this simple, non-invasive and flexible optical bedside method may be used for functional brain mapping.