1. Primary intracranial leiomyosarcoma among patients with AIDS in the era of new chemotherapeutic and biological agents.
- Author
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Francisco CN, Alejandria M, Salvaña EM, and Andal VMV
- Subjects
- Adult, Biopsy, Brain Neoplasms complications, Brain Neoplasms diagnostic imaging, Brain Neoplasms therapy, Chemotherapy, Adjuvant, Combined Modality Therapy, HIV Infections complications, Headache etiology, Humans, Leiomyosarcoma complications, Leiomyosarcoma diagnostic imaging, Leiomyosarcoma therapy, Magnetic Resonance Imaging, Male, Radiotherapy, Adjuvant, Tomography, X-Ray Computed, Brain Neoplasms pathology, Leiomyosarcoma pathology
- Abstract
Primary intracranial leiomyosarcoma (PIL) is a rare non-infectious aetiology of focal mass lesions among HIV-infected individuals. With only 16 published cases worldwide, information on its pathophysiology, risk factors, clinical course and management options is limited. We report two cases of PIL in HIV-infected Filipino men who presented with 1-3 months history of persistent headache, progressing in severity. Both had cranial MRI revealing intracranial mass diagnosed as leiomyosarcoma by excision biopsy and immunohistochemical staining. Both patients underwent adjuvant cranial radiotherapy and chemotherapy. Biologics were initiated in one patient. Both patients were alive with evidence of the disease., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2018
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