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8. Epigenetic variation in neonatal tissues in infants conceived using capacitation-in vitro maturation vs. in vitro fertilization

Author

Saucedo-Cuevas, Laura, primary, Ma, Mai P.Q., additional, Le, Anh H., additional, Akin, Nazli, additional, Pham, Toan D., additional, Ho, Tuong M., additional, Pita, Guillermo, additional, Gonzalez-Neira, Anna, additional, De Vos, Michel, additional, Smitz, Johan, additional, Anckaert, Ellen, additional, and Vuong, Lan N., additional

Published
2023
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13. Effects of lactate, super-GDF9, and low oxygen tension during bi-phasic in vitro maturation on the bioenergetic profiles of mouse cumulus–oocyte complex

Author

Akin, Nazli, primary, Ates, Gamze, additional, von Mengden, Lucia, additional, Herta, Anamaria-Cristina, additional, Meriggioli, Cecilia, additional, Billooye, Katy, additional, Stocker, William A, additional, Ghesquiere, Brecht, additional, Harrison, Craig A, additional, Cools, Wilfried, additional, Klamt, Fabio, additional, Massie, Ann, additional, Smitz, Johan, additional, and Anckaert, Ellen, additional

Published
2023
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17. A fresh start for IVM: capacitating the oocyte for development using pre-IVM.

Author

Gilchrist, Robert B, Ho, Tuong M, Vos, Michel De, Sanchez, Flor, Romero, Sergio, Ledger, William L, Anckaert, Ellen, Vuong, Lan N, and Smitz, Johan

Subjects
OVULATION, FERTILITY preservation, OVUM, OVARIAN follicle, MINIMAL art, GRANULOSA cells, HUMAN beings in art
Abstract

BACKGROUND While oocyte IVM is practiced sporadically it has not achieved widespread clinical practice globally. However, recently there have been some seminal advances in our understanding of basic aspects of oocyte biology and ovulation from animal studies that have led to novel approaches to IVM. A significant recent advance in IVM technology is the use of biphasic IVM approaches. These involve the collection of immature oocytes from small antral follicles from minimally stimulated patients/animals (without hCG-priming) and an ∼24 h pre-culture of oocytes in an advanced culture system ('pre-IVM') prior to IVM, followed by routine IVF procedures. If safe and efficacious, this novel procedure may stand to make a significant impact on human ART practices. OBJECTIVE AND RATIONALE The objectives of this review are to examine the major scientific advances in ovarian biology with a unique focus on the development of pre-IVM methodologies, to provide an insight into biphasic IVM procedures, and to report on outcomes from animal and clinical human data, including safety data. The potential future impact of biphasic IVM on ART practice is discussed. SEARCH METHODS Peer review original and review articles were selected from PubMed and Web of Science searches for this narrative review. Searches were performed using the following keywords: oocyte IVM, pre-IVM, biphasic IVM, CAPA-IVM, hCG-triggered/primed IVM, natural cycle IVF/M, ex-vivo IVM, OTO-IVM, oocyte maturation, meiotic competence, oocyte developmental competence, oocyte capacitation, follicle size, cumulus cell (CC), granulosa cell, COC, gap-junction communication, trans-zonal process, cAMP and IVM, cGMP and IVM, CNP and IVM, EGF-like peptide and IVM, minimal stimulation ART, PCOS. OUTCOMES Minimizing gonadotrophin use means IVM oocytes will be collected from small antral (pre-dominant) follicles containing oocytes that are still developing. Standard IVM yields suboptimal clinical outcomes using such oocytes, whereas pre-IVM aims to continue the oocyte's development ex vivo , prior to IVM. Pre-IVM achieves this by eliciting profound cellular changes in the oocyte's CCs, which continue to meet the oocyte's developmental needs during the pre-IVM phase. The literature contains 25 years of animal research on various pre-IVM and biphasic IVM procedures, which serves as a large knowledge base for new approaches to human IVM. A pre-IVM procedure based on c-type natriuretic peptide (named 'capacitation-IVM' (CAPA-IVM)) has undergone pre-clinical human safety and efficacy trials and its adoption into clinical practice resulted in healthy live birth rates not different from conventional IVF. WIDER IMPLICATIONS Over many decades, improvements in clinical IVM have been gradual and incremental but there has likely been a turning of the tide in the past few years, with landmark discoveries in animal oocyte biology finally making their way into clinical practice leading to improved outcomes for patients. Demonstration of favorable clinical results with CAPA-IVM, as the first clinically tested biphasic IVM system, has led to renewed interest in IVM as an alternative, low-intervention, low-cost, safe, patient-friendly ART approach, and especially for patients with PCOS. The same new approach is being used as part of fertility preservation in patients with cancer and holds promise for social oocyte freezing. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Impact of first chemotherapy exposure on follicle activation and survival in human cryopreserved ovarian tissue.

Author

Devos, Melody, Diaz Vidal, Paula, Bouziotis, Jason, Anckaert, Ellen, Dolmans, Marie-Madeleine, Demeestere, Isabelle, Devos, Melody, Diaz Vidal, Paula, Bouziotis, Jason, Anckaert, Ellen, Dolmans, Marie-Madeleine, and Demeestere, Isabelle

Abstract

Does chemotherapy exposure prior to ovarian tissue cryopreservation (OTC) impact the signaling pathways governing follicle activation and survival for prepubertal and postpubertal patients?, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

22. Effects of lactate, super-GDF9 and low oxygen tension during biphasic in vitro maturation on the bioenergetic profiles of mouse cumulus-oocyte-complex

Author

Akin, Nazli, primary, Ates, Gamze, additional, Mengden, Lucia von, additional, Herta, Anamaria-Cristina, additional, Meriggioli, Cecilia, additional, Billooye, Katy, additional, Stocker, William A., additional, Ghesquiere, Brecht, additional, Harrison, Craig A., additional, Klamt, Fabio, additional, Massie, Ann, additional, Smitz, Johan, additional, and Anckaert, Ellen, additional

Published
2022
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23. Severe primary IGF1 deficiency diagnosed by a standardized IGF1/ IGFBP3 generation test: The Belgian experience

Author

Ryckx, Sofie, Derycke, Christine, Anckaert, Ellen, Beauloye, Veronique, Beckers, Dominique, Brachet, Cecile, den Brinker, Marieke, De Waele, Kathleen, Dotremont, Hilde, Boros, Emese, Klink, Daniel, Lebrethon, Marie-Christine, Lysy, Philippe, Mouraux, Thierry, Parent, Anne-Simone, Rochtus, Ann, van der Straaten, Saskia, De Schepper, Jean, Pediatrics, Pathology/molecular and cellular medicine, Clinical Biology, Follicle Biology, Mental Health and Wellbeing research group, Clinical sciences, UZB Other, and Biology of the Testis

Published
2022

24. Severe primary IGF1 deficiency diagnosedby a standardized IGF1/ IGFBP3 generation test:The Belgian experience

Author

Ryckx, Sofie, Derycke, Christine, Anckaert, Ellen, Beauloye, Veronique, Beckers, Dominique, Brachet, Cecile, den Brinker, Marieke, De Waele, Kathleen, Dotremont, Hilde, Boros, Emese, Klink, Daniel, Lebrethon, Marie-Christine, Lysy, Philippe A, Mouraux, Thierry, Parent, Anne-Simone, Rochtus, Anne, van der Straaten, Saskia, De Schepper, Jean, Pathology/molecular and cellular medicine, Clinical Biology, Follicle Biology, Mental Health and Wellbeing research group, Clinical sciences, Biology of the Testis, and Pediatrics

Abstract

RFC10.2Background/Aim: Over the past 6 years, the IGF1/ IGFBP3generation test (IGFGT) has been used in Belgium in a standardized form to identify children with severe primary IGF1 deficiency(SPIGFD). In this study, the discordance of the IGF1 and IGFBP3responses during an IGFGT and the prevalence of SPIGFD wereanalyzed in a cohort of children with short stature (height SDS 7 µg/L).Methods: In total, 56 (35 male) children aged between 1.3 and14.8 years (median 7.5) underwent an IGFGT. Only 34 IGFGT were analyzed, because of non-persisting low serum IGF1 valuesand/or an underlying chronic disease in 22 children. Morningserum IGF1 and IGFBP3 concentrations were measured by theIDS-iSYS assay before and after 7 daily injections of GH (0.05 mg/kg bodyweight somatotropin) in the evening. An abnormal IGF1/IGFBP3 response was defined by a stimulated value remainingbelow gender and age specific basal reference limits. SPIGFD wasdefined by a low basal IGF1 together with a IGF1 response < 15µg/L and a IGFBP3 response < 400 µg/L during the IGFGT.Results: In 16/34 (47%) children, a normal basal serum IGF1by the IDS-iSYS assay was measured and paralleled with a normalserum IGFBP3 in 13 cases. Twelve (67 %) of the 18 children witha confirmed low basal IGF1 had a low serum IGFBP3, 6 (33 %) hadan abnormal IGF1 response and the same 6 cases had an abnormalIGFBP3 response, whereas 6 had a IGF1 response < 15 µg/L, 5 hada IGFBP3 response < 400 µg/L and 4 had both responses below thedefined limits. Genetic studies in 3 of these 4 cases confirmed apathogenic heterogenous GHR gene mutation (c.899 dup p. andc.876G>T) in 2 cases and a pathogenic PTPN11 mutation inanother case.Conclusion: In short children with persistent low IGF1 valuesand a normal stimulated GH peak, a low IGF1 status could be confirmed in only half of the cases using the IDS-iSYS assay. In thosechildren, a 100 % concordance between low stimulated IGF1 andlow stimulated IGFBP3 levels was observed during a standardized(high dose and prolonged up to 7 days) IGF1/ IGFBP3 generationtest, permitting finally the biochemical diagnosis of a severe primary IGF1 deficiency in 12 %.

Published
2022

28. Proceedings of the Oncofertility Congress of the 'Freezing Ovarian Tissue and Oocytes' (FOTO) Consortium Brussels.

Author

UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Dolmans, Marie-Madeleine, Demeestere, Isabelle, Anckaert, Ellen, De Vos, Michel, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Dolmans, Marie-Madeleine, Demeestere, Isabelle, Anckaert, Ellen, and De Vos, Michel

Abstract

No abstract available

Published
2022

37. Impact of first-line chemotherapy prior to ovarian tissue cryopreservation on primordial follicle activation and survival in pre-pubertal and young adult patients

Author

ESHRE Annual Meeting (virtual) (37th: 28/06 - 01/07/2021), Devos, Melody, Diaz Vidal, Paula, Anckaert, Ellen, Dolmans, Marie-Madeleine, Demeestere, Isabelle, ESHRE Annual Meeting (virtual) (37th: 28/06 - 01/07/2021), Devos, Melody, Diaz Vidal, Paula, Anckaert, Ellen, Dolmans, Marie-Madeleine, and Demeestere, Isabelle

Abstract

info:eu-repo/semantics/published

Published
2021

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