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3 results on '"Anaya-Ventura, Aristoteles"'

1. Polymorphism in the Matrix Metalloproteinase-2 Gene Promoter is Associated with Cervical Neoplasm Risk in Mexican Women

Author

Baltazar-Rodriguez, Luz M., Anaya-Ventura, Aristoteles, Andrade-Soto, Maricela, Monrroy-Guizar, Elisa A., Bautista-Lam, Jose R., Jonguitud-Olguin, Gregorio, Cepeda-Lopez, Friedman R., Centeno-Aguilar, Veronica A., Gonzalez-Hernandez, Nelida A., Soriano-Hernández, Alejandro D., Ramirez-Flores, Mario, Lugo-Trampe, Angel, Rodriguez-Sanchez, Iram P., Newton-Sanchez, Oscar A., and Delgado-Enciso, Ivan

Published
2008
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2. Matrix Metalloproteinase-2 Promoter Polymorphism Is Associated with Breast Cancer in a Mexican Population

Author

Delgado-Enciso, Iván, primary, Cepeda-Lopez, Friedman R., additional, Monrroy-Guizar, Elisa A., additional, Bautista-Lam, Jose R., additional, Andrade-Soto, Maricela, additional, Jonguitud-Olguin, Gregorio, additional, Rodriguez-Hernandez, Alejandrina, additional, Anaya-Ventura, Aristoteles, additional, Baltazar-Rodriguez, Luz M., additional, Orozco-Ruiz, Martha, additional, Soriano-Hernandez, Alejandro D., additional, Rodriguez-Sanchez, Iram P., additional, Lugo-Trampe, Angel, additional, Espinoza-Gomez, Francisco, additional, and Michel-Peregrina, Martha L., additional

Published
2007
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3. Matrix Metalloproteinase-2 Promoter Polymorphism Is Associated with Breast Cancer in a Mexican Population.

Author

Delgado-Enciso, Iván, Cepeda-Lopez, Friedman R., Monrroy-Guizar, Elisa A., Bautista-Lam, Jose R., Andrade-Soto, Maricela, Jonguitud-Olguin, Gregorio, Rodriguez-Hernandez, Alejandrina, Anaya-Ventura, Aristoteles, Baltazar-Rodriguez, Luz M., Orozco-Ruiz, Martha, Soriano-Hernandez, Alejandro D., Rodriguez-Sanchez, Iram P., Lugo-Trampe, Angel, Espinoza-Gomez, Francisco, and Michel-Peregrina, Martha L.

Subjects
METALLOPROTEINASES, PROTEOLYTIC enzymes, EXTRACELLULAR matrix proteins, GENETIC polymorphisms, BREAST cancer
Abstract

Background:Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism C>T transition at –1306 displayed a strong association with several cancers. Our study investigated whether or not the MMP-2 –1306C>T polymorphism contributed to the development of breast cancer (BC) in a Mexican population. Methods: 90 patients with BC and 96 control subjects were analyzed to detect MMP-2 –1306C>T polymorphism. Results: The frequency of MMP-2 CC genotype was significantly higher in BC patients when compared with the control group (OR 2.15; 95% CI 1.1–4.1). MMP-2 CC genotype frequency was more pronounced in younger subjects (≤50 years) at diagnosis (OR 2.66; 95% CI 1.04–6.96). Conclusion: The data suggest that MMP-2 –1306C>T polymorphism strongly contributes to the development of BC in the population studied, especially among women 50 years old and younger. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2008
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