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2. Proposed diagnostic criteria for arrhythmogenic cardiomyopathy: European Task Force consensus report

Author

Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J, Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, and Zorzi, Alessandro

Published
2024
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5. Cardiomyopathies in children: An overview

Author

Tsatsopoulou, Adalena, Protonotarios, Ioannis, Xylouri, Zafeirenia, Papagiannis, Ioannis, Anastasakis, Aris, Germanakis, Ioannis, Patrianakos, Alexandros, Nyktari, Evangelia, Gavras, Christoforos, Papadopoulos, Georgios, Meditskou, Soultana, Lazarou, Emilia, Miliou, Antigoni, and Lazaros, George

Published
2023
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8. Clinical Features and Natural History of Preadolescent Nonsyndromic Hypertrophic Cardiomyopathy

Author

Norrish, Gabrielle, Cleary, Aoife, Field, Ella, Cervi, Elena, Boleti, Olga, Ziółkowska, Lidia, Olivotto, Iacopo, Khraiche, Diala, Limongelli, Giuseppe, Anastasakis, Aris, Weintraub, Robert, Biagini, Elena, Ragni, Luca, Prendiville, Terence, Duignan, Sophie, McLeod, Karen, Ilina, Maria, Fernandez, Adrian, Marrone, Chiara, Bökenkamp, Regina, Baban, Anwar, Kubus, Peter, Daubeney, Piers E.F., Sarquella-Brugada, Georgia, Cesar, Sergi, Klaassen, Sabine, Ojala, Tiina H., Bhole, Vinay, Medrano, Constancio, Uzun, Orhan, Brown, Elspeth, Gran, Ferran, Sinagra, Gianfranco, Castro, Francisco J., Stuart, Graham, Yamazawa, Hirokuni, Barriales-Villa, Roberto, Garcia-Guereta, Luis, Adwani, Satish, Linter, Katie, Bharucha, Tara, Gonzales-Lopez, Esther, Siles, Ana, Rasmussen, Torsten B., Calcagnino, Margherita, Jones, Caroline B., De Wilde, Hans, Kubo, Toru, Felice, Tiziana, Popoiu, Anca, Mogensen, Jens, Mathur, Sujeev, Centeno, Fernando, Reinhardt, Zdenka, Schouvey, Sylvie, Elliott, Perry M., and Kaski, Juan Pablo

Published
2022
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9. Variant transthyretin amyloidosis (ATTRv) polyneuropathy in Greece: a broad overview with a focus on non-endemic unexplored regions of the country

Author

Koutsis, Georgios, Kastritis, Efstathios, Kontogeorgiou, Zoi, Kartanou, Chrisoula, Kokotis, Panagiotis, Rentzos, Michail, Breza, Marianthi, Kleopa, Kleopas A., Christodoulou, Kyproula, Oikonomou, Evangelos, Anastasakis, Aris, Angelidakis, Panagiotis, Sarmas, Ioannis, Kargiotis, Odysseas, Tzagournissakis, Minas, Zaganas, Ioannis, Foukarakis, Emmanouil, Sachpekidis, Vasileios, Papathoma, Alexandra, Panas, Marios, Stefanis, Leonidas, Dimopoulos, Meletios Athanasios, and Karadima, Georgia

Published
2021
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11. Proposed diagnostic criteria for arrhythmogenic cardiomyopathy:European Task Force consensus report

Author

Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, Zorzi, Alessandro, Corrado, Domenico, Anastasakis, Aris, Basso, Cristina, Bauce, Barbara, Blomström-Lundqvist, Carina, Bucciarelli-Ducci, Chiara, Cipriani, Alberto, De Asmundis, Carlo, Gandjbakhch, Estelle, Jiménez-Jáimez, Juan, Kharlap, Maria, McKenna, William J., Monserrat, Lorenzo, Moon, James, Pantazis, Antonis, Pelliccia, Antonio, Perazzolo Marra, Martina, Pillichou, Kalliopi, Schulz-Menger, Jeanette, Jurcut, Ruxandra, Seferovic, Petar, Sharma, Sanjay, Tfelt-Hansen, Jacob, Thiene, Gaetano, Wichter, Thomas, Wilde, Arthur, and Zorzi, Alessandro

Abstract

Arrhythmogenic cardiomyopathy (ACM) is a heart muscle disease characterized by prominent “non-ischemic” myocardial scarring predisposing to ventricular electrical instability. Diagnostic criteria for the original phenotype, arrhythmogenic right ventricular cardiomyopathy (ARVC), were first proposed in 1994 and revised in 2010 by an international Task Force (TF). A 2019 International Expert report appraised these previous criteria, finding good accuracy for diagnosis of ARVC but a lack of sensitivity for identification of the expanding phenotypic disease spectrum, which includes left-sided variants, i.e., biventricular (ABVC) and arrhythmogenic left ventricular cardiomyopathy (ALVC). The ARVC phenotype together with these left-sided variants are now more appropriately named ACM. The lack of diagnostic criteria for the left ventricular (LV) phenotype has resulted in clinical under-recognition of ACM patients over the 4 decades since the disease discovery. In 2020, the “Padua criteria” were proposed for both right- and left-sided ACM phenotypes. The presently proposed criteria represent a refinement of the 2020 Padua criteria and have been developed by an expert European TF to improve the diagnosis of ACM with upgraded and internationally recognized criteria. The growing recognition of the diagnostic role of CMR has led to the incorporation of myocardial tissue characterization findings for detection of myocardial scar using the late‑gadolinium enhancement (LGE) technique to more fully characterize right, biventricular and left disease variants, whether genetic or acquired (phenocopies), and to exclude other “non-scarring” myocardial disease. The “ring-like’ pattern of myocardial LGE/scar is now a recognized diagnostic hallmark of ALVC. Additional diagnostic criteria regarding LV depolarization and repolarization ECG abnormalities and ventricular arrhythmias of LV origin are also provided. These proposed upgrading of diagnostic criteria represents a working framewor

Published
2024

12. Relationship Between Maximal Left Ventricular Wall Thickness and Sudden Cardiac Death in Childhood Onset Hypertrophic Cardiomyopathy

Author

Norrish, Gabrielle, Ding, Tao, Field, Ella, Cervi, Elena, Ziółkowska, Lidia, Olivotto, Iacopo, Khraiche, Diala, Limongelli, Giuseppe, Anastasakis, Aris, Weintraub, Robert, Biagini, Elena, Ragni, Luca, Prendiville, Terrence, Duignan, Sophie, McLeod, Karen, Ilina, Maria, Fernández, Adrián, Marrone, Chiara, Bökenkamp, Regina, Baban, Anwar, Kubus, Peter, Daubeney, Piers E.F., Sarquella-Brugada, Georgia, Cesar, Sergi, Klaassen, Sabine, Ojala, Tiina H., Bhole, Vinay, Medrano, Constancio, Uzun, Orhan, Brown, Elspeth, Gran, Ferran, Sinagra, Gianfranco, Castro, Francisco J., Stuart, Graham, Vignati, Gabriele, Yamazawa, Hirokuni, Barriales-Villa, Roberto, Garcia-Guereta, Luis, Adwani, Satish, Linter, Katie, Bharucha, Tara, Garcia-Pavia, Pablo, Siles, Ana, Rasmussen, Torsten B., Calcagnino, Margherita, Jones, Caroline B., De Wilde, Hans, Kubo, Toru, Felice, Tiziana, Popoiu, Anca, Mogensen, Jens, Mathur, Sujeev, Centeno, Fernando, Reinhardt, Zdenka, Schouvey, Sylvie, O’Mahony, Costas, Omar, Rumana Z., Elliott, Perry M., and Kaski, Juan Pablo

Published
2022
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13. Epidemiology of Pediatric Cardiomyopathy in a Mediterranean Population.

Author

Bagkaki, Alena, Parthenakis, Fragiskos, Chlouverakis, Gregory, Anastasakis, Aris, Papagiannis, Ioannis, Galanakis, Emmanouil, and Germanakis, Ioannis

Subjects
HEART murmurs, CARDIOMYOPATHIES, VENTRICULAR ejection fraction, NOONAN syndrome, SEX distribution, FISHER exact test, PROBABILITY theory, SYNCOPE, RETROSPECTIVE studies, DILATED cardiomyopathy, CARDIAC hypertrophy, AGE distribution, HEART failure, TREATMENT effectiveness, DESCRIPTIVE statistics, RACE, AGE factors in disease, GLYCOGEN storage disease, HEART transplantation, MEDICAL records, ACQUISITION of data, SEIZURES (Medicine), IMPLANTABLE cardioverter-defibrillators, DISEASE complications, CONFIDENCE intervals, CARDIAC arrest, FATTY acids, MEDITERRANEAN peoples, ECHOCARDIOGRAPHY, PHENOTYPES, GENETIC testing
Abstract

Background. Our knowledge regarding the epidemiology of pediatric cardiomyopathy is based on large national population studies reporting an annual incidence of 1 case per 100,000 children, with a higher incidence observed in infancy and among selected populations. The aim here is to document the epidemiology of pediatric cardiomyopathy in a Mediterranean population. Methods. Children younger than 18 years of age living on the Mediterranean island of Crete, Greece, who have been evaluated since the establishment of tertiary pediatric cardiology services (2002–2022) were included in this retrospective study. Results. A total of 40 children were included, corresponding to an average annual incidence of pediatric cardiomyopathy of 1.59 cases (95% CI: 1.4–2.3) and a prevalence of 26 cases per 100,000 children. In decreasing order of frequency, most cases corresponded to dilated (50%), followed by hypertrophic (42.5%), arrhythmogenic (5%), and restrictive (2.5%) cardiomyopathy. An etiology was identified in 40%, including a genetic diagnosis in 22.5%. Conclusions. The incidence of pediatric cardiomyopathy in the Mediterranean island of Crete is higher compared with that reported previously for other Caucasian populations. Further study is needed to investigate the exact prevalence and specific genetic factors associated with the epidemiology of pediatric cardiomyopathy in Mediterranean populations. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Cardiomyopathies in children and adolescents: aetiology, management, and outcomes in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Registry.

Author

Kaski, Juan Pablo, Norrish, Gabrielle, Blanes, Juan Ramon Gimeno, Charron, Philippe, Elliott, Perry, Tavazzi, Luigi, Tendera, Michal, Laroche, Cécile, Maggioni, Aldo P, Baban, Anwar, Khraiche, Diala, Ziolkowska, Lidia, Limongelli, Giuseppe, Ojala, Tiina, Gorenflo, Matthias, Anastasakis, Aris, Mostafa, Shaimaa, Caforio, Alida L P, and Investigators, the EORP Paediatric Cardiomyopathy Registry

Subjects
ARRHYTHMOGENIC right ventricular dysplasia, CARDIAC research, MYOCARDITIS, CARDIOMYOPATHIES, ETIOLOGY of diseases, GENETIC disorders
Abstract

Background and Aims Childhood-onset cardiomyopathies are rare and poorly characterized. This study examined the baseline characteristics and 1-year follow-up of children with cardiomyopathy in the first European Cardiomyopathy Registry. Methods Prospective data were collected on individuals aged 1–<18 years enrolled in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis long-term registry (June 2014–December 2016). Results A total of 633 individuals aged ≤18 years with hypertrophic [HCM; n = 388 (61.3%)], dilated [DCM; n = 206 (32.5%)], restrictive [RCM; n = 28 (4.4%)], and arrhythmogenic right ventricular cardiomyopathy [ARVC; n = 11 (1.7%)] were enrolled by 23 referral centres in 14 countries. Median age at diagnosis was 4.0 [interquartile range (IQR) 0–10] years, and there was a male predominance [ n = 372 (58.8%)] across all subtypes, with the exception of DCM diagnosed <10 years of age; 621 (98.1%) patients were receiving cardiac medication and 80 (12.6%) had an implantable cardioverter-defibrillator. A total of 253 patients (253/535, 47.3%) had familial disease. Genetic testing was performed in 414 (67.8%) patients with a pathogenic or likely pathogenic variant reported in 250 (60.4%). Rare disease phenocopies were reported in 177 patients (28.0%) and were most frequent in patients under 10 years [142 (30.9%) vs. 35 (19.6%); P =.003]. Over a median follow-up of 12.5 months (IQR 11.3–15.3 months), 18 patients (3.3%) died [HCM n = 9 (2.6%), DCM n = 5 (3.0%), RCM n = 4 (16.0%)]. Heart failure events were most frequent in RCM patients (36.0%). Conclusions The findings confirm the heterogeneous aetiology of childhood cardiomyopathies and show a high frequency of familial disease. Outcomes differed by cardiomyopathy subtype, highlighting a need for disease-specific evaluation and treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Corrigendum to ‘Syncope in hypertrophic cardiomyopathy (part II): An expert consensus statement on the diagnosis and management’ [International Journal of Cardiology, 2023, 41:180–186]

Author

Brignole, Michele, primary, Cecchi, Franco, additional, Anastasakis, Aris, additional, Crotti, Lia, additional, Deharo, Jean Claude, additional, Elliott, Perry M., additional, Fedorowski, Artur, additional, Kaski, Juan Pablo, additional, Limongelli, Giuseppe, additional, Maron, Martin S., additional, Olivotto, Iacopo, additional, Ommen, Steve R., additional, Parati, Gianfranco, additional, Shen, Win, additional, Ungar, Andrea, additional, and Wilde, Arthur, additional

Published
2023
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17. Programmed ventricular stimulation predicts arrhythmic events and survival in hypertrophic cardiomyopathy

Author

Gatzoulis, Konstantinos A., Georgopoulos, Stavros, Antoniou, Christos-Konstantinos, Anastasakis, Aris, Dilaveris, Polychronis, Arsenos, Petros, Sideris, Skevos, Tsiachris, Dimitris, Archontakis, Stefanos, Sotiropoulos, Elias, Theopistou, Artemisia, Skiadas, Ioannis, Kallikazaros, Ioannis, Stefanadis, Christodoulos, and Tousoulis, Dimitrios

Published
2018
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18. Corrigendum to ‘Syncope in hypertrophic cardiomyopathy (part II): An expert consensus statement on the diagnosis and management’ [International Journal of Cardiology, 2023, 41:180–186]

Author

Brignole, Michele, Cecchi, Franco, Anastasakis, Aris, Crotti, Lia, Deharo, Jean Claude, Elliott, Perry M., Fedorowski, Artur, Kaski, Juan Pablo, Limongelli, Giuseppe, Maron, Martin S., Olivotto, Iacopo, Ommen, Steve R., Parati, Gianfranco, Shen, Win, Ungar, Andrea, and Wilde, Arthur

Published
2024
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20. Impaired cerebral autoregulation in Fabry disease: A case‐control study

Author

Palaiodimou, Lina, primary, Papagiannopoulou, Georgia, additional, Bakola, Eleni, additional, Papadopoulou, Marianna, additional, Kokotis, Panagiotis, additional, Moschovos, Christos, additional, Vrettou, Agathi‐Rosa, additional, Kapsia, Eleni, additional, Petras, Dimitrios, additional, Anastasakis, Aris, additional, Lionaki, Sophia, additional, Vlachopoulos, Charalambos, additional, Boletis, Ioannis N., additional, Zompola, Christina, additional, and Tsivgoulis, Georgios, additional

Published
2023
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21. Syncope in hypertrophic cardiomyopathy (part II): An expert consensus statement on the diagnosis and management

Author

Brignole, M, Cecchi, F, Anastasakis, A, Crotti, L, Deharo, J, Elliott, P, Fedorowski, A, Kaski, J, Limongelli, G, Maron, M, Olivotto, I, Ommen, S, Parati, G, Shen, W, Ungar, A, Wilde, A, Brignole, Michele, Cecchi, Franco, Anastasakis, Aris, Crotti, Lia, Deharo, Jean Claude, Elliott, Perry M, Fedorowski, Artur, Kaski, Juan Pablo, Limongelli, Giuseppe, Maron, Martin S, Olivotto, Iacopo, Ommen, Steve R, Parati, Gianfranco, Shen, Win, Ungar, Andrea, Wilde, Arthur, Brignole, M, Cecchi, F, Anastasakis, A, Crotti, L, Deharo, J, Elliott, P, Fedorowski, A, Kaski, J, Limongelli, G, Maron, M, Olivotto, I, Ommen, S, Parati, G, Shen, W, Ungar, A, Wilde, A, Brignole, Michele, Cecchi, Franco, Anastasakis, Aris, Crotti, Lia, Deharo, Jean Claude, Elliott, Perry M, Fedorowski, Artur, Kaski, Juan Pablo, Limongelli, Giuseppe, Maron, Martin S, Olivotto, Iacopo, Ommen, Steve R, Parati, Gianfranco, Shen, Win, Ungar, Andrea, and Wilde, Arthur

Abstract

Syncopal events in patients with hypertrophic cardiomyopathy (HCM) are of concern as they are a vital consideration in algorithms for risk stratification for sudden cardiac death (SCD) and ICD implantation. However, the cause of syncope is often under-investigated and/or unexplained. Current syncope guidelines do not provide a detailed definition of unexplained syncope. To address this important gap, an international panel of experts in the field of both syncope and HCM wrote a consensus document with the aim of providing practical guidance for the diagnosis and management of syncope in patients with HCM.

Published
2023

22. D313Y Variant in Fabry Disease

Author

Palaiodimou, Lina, primary, Stefanou, Maria-Ioanna, additional, Bakola, Eleni, additional, Papadopoulou, Marianna, additional, Kokotis, Panagiotis, additional, Vrettou, Agathi-Rosa, additional, Kapsia, Eleni, additional, Petras, Dimitrios, additional, Anastasakis, Aris, additional, Xifaras, Nikolaos, additional, Karachaliou, Eleni, additional, Touloumi, Giota, additional, Vlachopoulos, Charalambos, additional, Boletis, Ioannis N., additional, Giannopoulos, Sotirios, additional, Tsivgoulis, Georgios, additional, and Zompola, Christina, additional

Published
2022
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25. Atrial fibrillation in hypertrophic cardiomyopathy – A contemporary mini-review

Author

Dragasis, Stylianos, primary, Vlachos, Konstantinos, additional, Kariki, Ourania, additional, Koskina, Stavroula, additional, Zygouri, Andromahi, additional, Patsiotis, Ilias G., additional, Anastasakis, Aris, additional, Athanasopoulos, George, additional, Ritsatos, Konstantinos, additional, Letsas, Konstantinos, additional, and Efremidis, Michael, additional

Published
2022
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26. Risk and Protective Factors for Sudden Cardiac Death: An Umbrella Review of Meta-Analyses

Author

Tsartsalis, Dimitrios, Korela, Dafni, Karlsson, Lars, Foukarakis, Emmanouil, Svensson, Anneli, Anastasakis, Aris, Venetsanos, Dimitrios, Aggeli, Constantina, Tsioufis, Costas, Braunschweig, Frieder, Dragioti, Elena, Charitakis, Emmanouil, Tsartsalis, Dimitrios, Korela, Dafni, Karlsson, Lars, Foukarakis, Emmanouil, Svensson, Anneli, Anastasakis, Aris, Venetsanos, Dimitrios, Aggeli, Constantina, Tsioufis, Costas, Braunschweig, Frieder, Dragioti, Elena, and Charitakis, Emmanouil

Abstract

Background: Sudden cardiac death (SCD) is a global public health issue, accounting for 10-20% of deaths in industrialized countries. Identification of modifiable risk factors may reduce SCD incidence. Methods: This umbrella review systematically evaluates published meta-analyses of observational and randomized controlled trials (RCT) for the association of modifiable risk and protective factors of SCD. Results: Fifty-five meta-analyses were included in the final analysis, of which 31 analyzed observational studies and 24 analyzed RCTs. Five associations of meta-analyses of observational studies presented convincing evidence, including three risk factors [diabetes mellitus (DM), smoking, and early repolarization pattern (ERP)] and two protective factors [implanted cardiac defibrillator (ICD) and physical activity]. Meta-analyses of RCTs identified five protective factors with a high level of evidence: ICDs, mineralocorticoid receptor antagonist (MRA), beta-blockers, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors in patients with HF. On the contrary, other established, significant protective agents [i.e., amiodarone and statins along with angiotensin-converting enzyme (ACE) inhibitors in heart failure (HF)], did not show credibility. Likewise, risk factors as left ventricular ejection fraction in HF, and left ventricular hypertrophy, non-sustain ventricular tachycardia, history of syncope or aborted SCD in pediatric patients with hypertrophic cardiomyopathy, presented weak or no evidence. Conclusions: Lifestyle risk factors (physical activity, smoking), comorbidities like DM, and electrocardiographic features like ERP constitute modifiable risk factors of SCD. Alternatively, the use of MRA, beta-blockers, SGLT-2 inhibitors, and ICD in patients with HF are credible protective factors. Further investigation targeted in specific populations will be important for reducing the burden of SCD.

Published
2022
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28. Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator

Author

Protonotarios, Alexandros, primary, Bariani, Riccardo, additional, Cappelletto, Chiara, additional, Pavlou, Menelaos, additional, García-García, Alba, additional, Cipriani, Alberto, additional, Protonotarios, Ioannis, additional, Rivas, Adrian, additional, Wittenberg, Regitze, additional, Graziosi, Maddalena, additional, Xylouri, Zafeirenia, additional, Larrañaga-Moreira, José M, additional, de Luca, Antonio, additional, Celeghin, Rudy, additional, Pilichou, Kalliopi, additional, Bakalakos, Athanasios, additional, Lopes, Luis Rocha, additional, Savvatis, Konstantinos, additional, Stolfo, Davide, additional, Dal Ferro, Matteo, additional, Merlo, Marco, additional, Basso, Cristina, additional, Freire, Javier Limeres, additional, Rodriguez-Palomares, Jose F, additional, Kubo, Toru, additional, Ripoll-Vera, Tomas, additional, Barriales-Villa, Roberto, additional, Antoniades, Loizos, additional, Mogensen, Jens, additional, Garcia-Pavia, Pablo, additional, Wahbi, Karim, additional, Biagini, Elena, additional, Anastasakis, Aris, additional, Tsatsopoulou, Adalena, additional, Zorio, Esther, additional, Gimeno, Juan R, additional, Garcia-Pinilla, Jose Manuel, additional, Syrris, Petros, additional, Sinagra, Gianfranco, additional, Bauce, Barbara, additional, and Elliott, Perry M, additional

Published
2022
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29. Risk and Protective Factors for Sudden Cardiac Death: An Umbrella Review of Meta-Analyses

Author

Tsartsalis, Dimitrios, primary, Korela, Dafni, additional, Karlsson, Lars O., additional, Foukarakis, Emmanouil, additional, Svensson, Anneli, additional, Anastasakis, Aris, additional, Venetsanos, Dimitrios, additional, Aggeli, Constantina, additional, Tsioufis, Costas, additional, Braunschweig, Frieder, additional, Dragioti, Elena, additional, and Charitakis, Emmanouil, additional

Published
2022
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31. Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases

Author

Pinto, Yigal M., Elliott, Perry M., Arbustini, Eloisa, Adler, Yehuda, Anastasakis, Aris, Böhm, Michael, Duboc, Denis, Gimeno, Juan, de Groote, Pascal, Imazio, Massimo, Heymans, Stephane, Klingel, Karin, Komajda, Michel, Limongelli, Giuseppe, Linhart, Ales, Mogensen, Jens, Moon, James, Pieper, Petronella G., Seferovic, Petar M., Schueler, Stephan, Zamorano, Jose L., Caforio, Alida L.P., and Charron, Philippe

Published
2016
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33. European Cardiomyopathy Pilot Registry: EURObservational Research Programme of the European Society of Cardiology

Author

Elliott, Perry, Charron, Philippe, Blanes, Juan Ramon Gimeno, Tavazzi, Luigi, Tendera, Michal, Konté, Marème, Laroche, Cécile, Maggioni, Aldo P., Anastasakis, Aris, Arbustini, Eloisa, Asselbergs, Folkert W., Axelsson, Anna, Brito, Dulce, Caforio, Alida L.P., Carr-White, Gerald, Czekaj, Agata, Damy, Thibaud, Devoto, Emmanuela, Favalli, Valentina, Findlay, Iain, Garcia-Pavia, Pablo, Hagège, Albert, Heliö, Tiina, Iliceto, Sabino, Isnard, Richard, Jansweijer, Joeri A., Limongelli, Giuseppe, Linhart, Ales, Cuenca, David López, Mansencal, Nicolas, McKeown, Pascal, Mogensen, Jens, Mohiddin, Saidi A., Monserrat, Lorenzo, Olivotto, Iacopo, Rapezzi, Claudio, Rigopoulos, A.G., Rosmini, Stefania, Pfeiffer, Barbara, and Wicks, Eleanor

Published
2016
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34. A novel homozygousALPK3variant associated with cardiomyopathy and skeletal muscle involvement

Author

Papadopoulos, Constantinos, primary, Kekou, Kiriaki, additional, Anastasakis, Aris, additional, Svingou, Maria, additional, Malfatti, Edoardo, additional, Metay, Corinne, additional, Chrysanthou, Margarita, additional, Paschou, Christina, additional, Miliopoulos, Dimitris, additional, Efthimiadis, Georgios, additional, Adamopoulos, Stamatios, additional, and Papadimas, George, additional

Published
2021
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35. Atrial substrate characterization in patients with atrial fibrillation and hypertrophic cardiomyopathy: Evidence for an extensive fibrotic disease

Author

Efremidis, Michael, primary, Bazoukis, George, additional, Vlachos, Konstantinos, additional, Prappa, Efstathia, additional, Anastasakis, Aris, additional, Megarisiotou, Athanasia, additional, Dragasis, Stelios, additional, Asvestas, Dimitrios, additional, Mililis, Panagiotis, additional, Saplaouras, Athanasios, additional, Efremidis, Theodoros, additional, Batsouli, Athena, additional, Zimpounoumi, Natalia, additional, Valkanas, Kosmas, additional, Sideris, Antonios, additional, and Letsas, Konstantinos P., additional

Published
2021
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37. The current role of next-generation DNA sequencing in routine care of patients with hereditary cardiovascular conditions: a viewpoint paper of the European Society of Cardiology working group on myocardial and pericardial diseases and members of the European Society of Human Genetics

Author

Mogensen, Jens, van Tintelen, J. Peter, Fokstuen, Siv, Elliott, Perry, van Langen, Irene M., Meder, Benjamin, Richard, Pascale, Syrris, Petros, Caforio, Alida L.P., Adler, Yehuda, Anastasakis, Aris, Gimeno, Juan R., Klingel, Karin, Linhart, Ales, Imazio, Massimo, Pinto, Yigal, Newbery, Ruth, Schmidtke, Joerg, and Charron, Philippe

Published
2015
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39. Variant in Fabry Disease: A Systematic Review and Meta-analysis.

Author

Palaiodimou, Lina, Stefanou, Maria-Ioanna, Bakola, Eleni, Papadopoulou, Marianna, Kokotis, Panagiotis, Vrettou, Agathi-Rosa, Kapsia, Eleni, Petras, Dimitrios, Anastasakis, Aris, Xifaras, Nikolaos, Karachaliou, Eleni, Touloumi, Giota, Vlachopoulos, Charalambos, Boletis, Ioannis N., Giannopoulos, Sotirios, Tsivgoulis, Georgios, and Zompola, Christina

Published
2022
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42. Mitral valve in hypertrophic cardiomyopathy: a three-dimensional transesophageal study

Author

Venieri, Erifili Aggeli, Constantina Anastasakis, Aris and Sambatakou, Helen Stefanadis, Christodoulos Tousoulis, Dimitrios

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Background: It is reported that the mitral valve (MV) in hypertrophic cardiomyopathy (HCM) has structural abnormalities. Purpose: To assess the MV in HCM patients using Three-Dimensional Transesophageal Echocardiography (3DTEE). Methods: Transthoracic and 3DTEE studies focused on the mitral valve were performed prospectively in 21 HCM patients with obstruction (Group I), 37 HCM patients without obstruction (Group II) and 28 controls (Group III). Results: The aortomitral angle was less obtuse in groups I and II compared with group III (104.6 +/- 6.7 degrees vs 107.6 +/- 8.5 degrees vs 112.9 +/- 3.2 degrees, p < 0.001) and the annulus height was larger (11.6 +/- 1.3 mm vs 11.6 +/- 2 mm vs 9.3 +/- 1.1 mm, p < 0.001). Patients in group I compared with groups II and III had increased ratio of anterior leaflet length to left ventricular outflow tract (LVOT) diameter (1.9 +/- 0.1 vs 1.7 +/- 0.3 vs 1.3 +/- 0.1, p < 0.05) and anterior displacement of the coaptation line as showed by the reduced ratio of anterior to posterior leaflet length in the projection plane (1.7 +/- 0.4 mm vs 2.2 +/- 0.7 mm vs 2.4 +/- 0.7 mm, p < 0.05). In groups I and II there was a positive correlation between the MV annulus height and the presence of non-sustained ventricular tachycardia (r(s) = 0.25, p < 0.05). Conclusion: The MV in HCM patients with or without obstruction shares some common anatomic features. Additionally, the MV in patients with obstruction has unique characteristics that appear to contribute to LVOT obstruction. (C) 2019 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.

Published
2021

43. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)

Author

Elliott, Perry M., Anastasakis, Aris, Borger, Michael A., Borggrefe, Martin, Cecchi, Franco, Charron, Philippe, Hagege, Albert Alain, Lafont, Antoine, Limongelli, Giuseppe, Mahrholdt, Heiko, McKenna, William J., Mogensen, Jens, Nihoyannopoulos, Petros, Nistri, Stefano, Pieper, Petronella G., Pieske, Burkert, Rapezzi, Claudio, Rutten, Frans H., Tillmanns, Christoph, Watkins, Hugh, OʼMahony, Constantinos, Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J., Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Çetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W., Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, Hasdai, David, Ponikowski, Piotr, Achenbach, Stephan, Alfonso, Fernando, Basso, Cristina, Cardim, Nuno Miguel, Gimeno, Juan Ramón, Heymans, Stephane, Holm, Per Johan, Keren, Andre, Kirchhof, Paulus, Kolh, Philippe, Lionis, Christos, Muneretto, Claudio, Priori, Silvia, Salvador, Maria Jesus, Wolpert, Christian, and Zamorano, Jose Luis

Published
2014
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45. Current and emerging perspectives on pathophysiology, diagnosis, and management of hypertrophic cardiomyopathy

Author

Gartzonikas, Ilias K., Naka, Katerina K., and Anastasakis, Aris

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common genetically inherited cardiomyopathy with an autosomal dominant inheritance pattern. A disease-causing gene is found between 34% and >60% of the times and the two most frequently mutated genes, which encode sarcomeric proteins, are MYBPC3 and MYH7. HCM is a diagnosis of exclusion since secondary causes of left ventricular hypertrophy should first be ruled out. These include hypertension, aortic stenosis, infiltrative disease, metabolic and endocrine disorders, mitochondrial cardiomyopathies, neuromuscular disorders, malformation syndromes and some chronic drug use. The disease is characterized by great heterogeneity of its clinical manifestations, however diastolic dysfunction and increased ventricular arrhythmogenesis are commonly seen. Current HCM therapies focus on symptom management and prevention of sudden cardiac death. Symptom management includes the use of pharmacological agents, elimination of medication promoting outflow track obstruction, control of comorbid conditions and invasive procedures, whereas in the prevention of sudden cardiac death, implantable cardiac defibrillators and antiarrhythmic drugs are used. A targeted therapy for LVOTO represented by allosteric cardiac myosin inhibitors has been developed. In terms of sport participation, a more liberal approach is recently recommended, after careful evaluation and common-shared decision. The application of the current therapies has lowered HCM mortality rates to <1.0%/year, however it appears to have shifted focus to heart failure and atrial fibrillation, as the predominant causes of disease-related morbidity and mortality and, therefore, unmet treatment need. With improved understanding of the genetic and molecular basis of HCM, the present decade will witness novel treatments for disease prevention and modification.

Published
2023
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46. 1 The role of the electrocardiographic phenotype in risk stratification for sudden cardiac death in childhood hypertrophic cardiomyopathy

Author

Topriceanu, Constantin-Cristian, primary, Norrish, Gabrielle, additional, Qu, Chen, additional, Fiend, Ella, additional, Walsh, Helen, additional, Ziółkowska, Lidia, additional, Olivotto, Iacopo, additional, Passantino, Silvia, additional, Favilli, Silvia, additional, Anastasakis, Aris, additional, Vlagkouli, Vasiliki, additional, Weintraub, Robert, additional, King, Ingrid, additional, Biagini, Elena, additional, Ragni, Lucaa, additional, Prendiville, Terence, additional, Duignan, Sophie, additional, McLeod, Karen, additional, Ilina, Maria, additional, Fernández, Adrian, additional, Bökenkamp, Regina, additional, Baban, Anwar, additional, Drago, Drago, additional, Kubuš, Peter, additional, Daubeney, Piers, additional, Chivers, Sian, additional, Sarquella-Brugada, Georgia, additional, Cesar, Sergi, additional, Marrone, Chiara, additional, Medrano, Constancio, additional, Garcia-Roves Reyes, Alvarez, additional, Uzun, Orhan, additional, Gran Ipina, Ferran, additional, Castro Garcia, FJ, additional, Gimeno, Juan Ramón, additional, Barriales-Villa, Roberto, additional, Rueda, Fernando, additional, Adwani, Satish, additional, Searle, Jonathan, additional, Bharucha, Tara, additional, Siles, Ana, additional, Usano, Ana, additional, Rasmussen, Torsten Bloch, additional, Jones, Caroline, additional, Kubo, T, additional, Mogensen, Jens, additional, Reinhardt, Zdenka, additional, Cervi, Elena, additional, Elliott, Perry, additional, Omar, Rumana, additional, and Kaski, Juan, additional

Published
2021
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48. 2014 ESC Guidelines on Diagnosis and Management of Hypertrophic Cardiomyopathy

Author

Elliott, Perry M., Anastasakis, Aris, Borger, Michael A., Borggrefe, Martin, Cecchi, Franco, Charron, Philippe, Hagege, Albert Alain, Lafont, Antoine, Limongelli, Giuseppe, Mahrholdt, Heiko, McKenna, William J., Mogensen, Jens, Nihoyannopoulos, Petros, Nistri, Stefano, Pieper, Petronella G., Pieske, Burkert, Rapezzi, Claudio, Rutten, Frans H., Tillmanns, Christoph, and Watkins, Hugh

Published
2015
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49. Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria

Author

Corrado, Domenico, Perazzolo Marra, Martina, Zorzi, Alessandro, Beffagna, Giorgia, Cipriani, Alberto, De Lazzari, Manuel, Migliore, Federico, Pilichou, Kalliopi, Rampazzo, Alessandra, Rigato, Ilaria, Rizzo, Stefania, Thiene, Gaetano, Anastasakis, Aris, Asimaki, Angeliki, Bucciarelli-Ducci, Chiara, Haugaa, Kristine H, Marchlinski, Francis E, Mazzanti, Andrea, McKenna, William J, Pantazis, Antonis, Pelliccia, Antonio, Schmied, Christian, Sharma, Sanjay, Wichter, Thomas, Bauce, Barbara, Basso, Cristina, Corrado, Domenico, Perazzolo Marra, Martina, Zorzi, Alessandro, Beffagna, Giorgia, Cipriani, Alberto, De Lazzari, Manuel, Migliore, Federico, Pilichou, Kalliopi, Rampazzo, Alessandra, Rigato, Ilaria, Rizzo, Stefania, Thiene, Gaetano, Anastasakis, Aris, Asimaki, Angeliki, Bucciarelli-Ducci, Chiara, Haugaa, Kristine H, Marchlinski, Francis E, Mazzanti, Andrea, McKenna, William J, Pantazis, Antonis, Pelliccia, Antonio, Schmied, Christian, Sharma, Sanjay, Wichter, Thomas, Bauce, Barbara, and Basso, Cristina

Abstract

The original designation of "Arrhythmogenic right ventricular (dysplasia/) cardiomyopathy"(ARVC) was used by the scientists who first discovered the disease, in the pre-genetic and pre-cardiac magnetic resonance era, to describe a new heart muscle disease predominantly affecting the right ventricle, whose cardinal clinical manifestation was the occurrence of malignant ventricular arrhythmias. Subsequently, autopsy investigations, genotype-phenotype correlations studies and the increasing use of contrast-enhancement cardiac magnetic resonance showed that the fibro-fatty replacement of the myocardium represents the distinctive phenotypic feature of the disease that affects the myocardium of both ventricles, with left ventricular involvement which may parallel or exceed the severity of right ventricular involvement. This has led to the new designation of "Arrhythmogenic Cardiomyopathy" (ACM), that represents the evolution of the original term of ARVC. The present International Expert Consensus document proposes an upgrade of the criteria for diagnosis of the entire spectrum of the phenotypic variants of ACM. The proposed "Padua criteria" derive from the diagnostic approach to ACM, which has been developed over 30 years by the multidisciplinary team of basic researchers and clinical cardiologists of the Medical School of the University of Padua. The Padua criteria are a working framework to improve the diagnosis of ACM by introducing new diagnostic criteria regarding tissue characterization findings by contrast-enhanced cardiac magnetic resonance, depolarization/repolarization ECG abnormalities and ventricular arrhythmia features for diagnosis of the left ventricular phenotype. The proposed diagnostic criteria need to be further validated by future clinical studies in large cohorts of patients.

Published
2020

50. The role of the electrocardiographic phenotype in risk stratification for sudden cardiac death in childhood hypertrophic cardiomyopathy

Author

Norrish, Gabrielle, primary, Topriceanu, Cristian, additional, Qu, Chen, additional, Field, Ella, additional, Walsh, Helen, additional, Ziółkowska, Lidia, additional, Olivotto, Iacopo, additional, Passantino, Silvia, additional, Favilli, Silvia, additional, Anastasakis, Aris, additional, Vlagkouli, Vasiliki, additional, Weintraub, Robert, additional, King, Ingrid, additional, Biagini, Elena, additional, Ragni, Luca, additional, Prendiville, Terrence, additional, Duignan, Sophie, additional, McLeod, Karen, additional, Ilina, Maria, additional, Fernández, Adrian, additional, Bökenkamp, Regina, additional, Baban, Anwar, additional, Drago, Fabrizio, additional, Kubuš, Peter, additional, Daubeney, Piers E F, additional, Chivers, Sian, additional, Sarquella-Brugada, Georgia, additional, Cesar, Sergi, additional, Marrone, Chiara, additional, Medrano, Constancio, additional, Alvarez Garcia-Roves, Reyes, additional, Uzun, Orhan, additional, Gran, Ferran, additional, Castro, Fernandez J, additional, Gimeno, Juan R, additional, Barriales-Villa, Roberto, additional, Rueda, Fernando, additional, Adwani, Satish, additional, Searle, Jonathan, additional, Bharucha, Tara, additional, Siles, Ana, additional, Usano, Ana, additional, Rasmussen, Torsten B, additional, Jones, Caroline B, additional, Kubo, Toru, additional, Mogensen, Jens, additional, Reinhardt, Zdenka, additional, Cervi, Elena, additional, Elliott, Perry M, additional, Omar, Rumana Z, additional, and Kaski, Juan P, additional

Published
2021
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