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6 results on '"Anamika Nayak"'

4. List of contributors

Author

Amitabha Acharya, Katya M. Aguilar-Pérez, Bhavna Alke, V. Ananthi, T. Angelin Swetha, A. Arun, Govindan Balasubramani, Monisha Banerjee, Hamed Barabadi, Maitree Bhattacharyya, Thulasinathan Boobalan, Abhispa Bora, Ariel P. Brown, Abdullah Çağlar, Zafer Ceylan, David Medina Cruz, G.H. Dinesh, Debjani Dutta, Ramakrishnan Geethalakshmi, Muthusamy Govarthanan, R. Guru Raj Rao, Habsah Hasan, Selcuk Hazir, Omid Hosseini, Chaudhery Mustansar Hussain, Hafiz M.N. Iqbal, J. Jeyakanthan, Kamyar Jounaki, Stefan Jurga, N.S. Kumar, P. Kumar, Nazan Kutlu, Ali Kılıçer, Lalita Ledwani, GS Lekshmi, Barbara M. Maciejewska, Mohammad Ali Mahjoub, Jennifer R. McCall, Samuel H. McCall, Dora I. Medina, Raciye Meral, Dasmawati Mohamad, K. Mohanrasu, Hamed Morad, Ebrahim Mostafavi, Sudip Nag, Anamika Nayak, J. Nirgund, SR Nivaz, Ebenezer Samuel James Obeth, Roberto Parra-Saldivar, Shama Parveen, Elahe Pishgahzadeh, Arnab Pramanik, Arivalagan Pugazhendhi, K.N. Purana, R Hari Krishna Raj, R. Karthik Raja, Shiwani Randhawa, Gustavo Ruiz-Pulido, Salar Sadeghian-Abadi, Himanshi Saini, Muthupandian Saravanan, Kathryn T. Sausman, D. Selvakumar, Chandni Sharma, S. Sil, N.B. Singh, Abdul Razack Sirajunnisa, G. Sivaprakash, Duraiarasan Surendhiran, Usman Taqui Syed, Syed Noeman Taqui, Oktay Tomar, Linh B. Truong, Shareefraza J. Ukkund, Hossein Vahidi, Mohini Verma, Karolina Wieszczycka, and Marta Woźniak-Budych

Published
2022

6. Modified tamarind kernel polysaccharide-based matrix alters neuro-keratinocyte cross-talk and serves as a suitable scaffold for skin tissue engineering

Author

Pradip K. Maji, Sweta Agarwal, Luna Goswami, Ashutosh Kumar, Priyanka Choudhury, Saurabh Chawla, Abhishek Singh, Chandan Goswami, and Anamika Nayak

Subjects
Keratinocytes, Materials science, Biocompatibility, Biocompatible Materials, Bioengineering, Human skin, 02 engineering and technology, Matrix (biology), 010402 general chemistry, 01 natural sciences, Rats, Sprague-Dawley, Biomaterials, Polysaccharides, In vivo, Tamarindus, medicine, Animals, Skin, Tissue Engineering, Hydrogels, 021001 nanoscience & nanotechnology, Rats, 0104 chemical sciences, HaCaT, medicine.anatomical_structure, Mechanics of Materials, Self-healing hydrogels, Biophysics, 0210 nano-technology, Keratinocyte, Ex vivo
Abstract

Advanced technologies like skin tissue engineering are requisite of various disorders where artificially synthesized materials need to be used as a scaffold in vivo, which in turn can allow the formation of functional skin and epidermal layer with all biological sensory functions. In this work, we present a set of hydrogels which have been synthesized by the method utilizing radical polymerization of a natural polymer extracted from kernel of Tamarindus indica, commonly known as Tamarind Kernel Powder (TKP) modified by utilizing the monomer acrylic acid (AA) in different mole ratios. These materials are termed as TKP: AA hydrogels and characterized by Atomic Force Microscopy (AFM), surface charge, and particle size distribution using Dynamic Light Scattering measurements. These materials are biocompatible with mouse dermal fibroblasts (NIH- 3T3) and human skin keratinocytes (HaCaT), as confirmed by MTT and biocompatibility assays. These TKP: AA hydrogels do not induce unwanted ROS signaling as confirmed by mitochondrial functionality determined by DCFDA staining, Mitosox imaging, and measuring the ATP levels. We demonstrate that in the co-culture system, TKP: AA allows the establishment of proper neuro-keratinocyte contact formation, suggesting that this hydrogel can be suitable for developing skin with sensory functions. Skin corrosion analysis on SD rats confirms that TKP: AA is appropriate for in vivo applications as well. This is further confirmed by in vivo compatibility and toxicity studies, including hemocompatibility and histopathology of liver and kidney upon direct introduction of hydrogel into the body. We propose that TKP: AA (1: 5) offers a suitable surface for skin tissue engineering with sensory functions applicable in vitro, in vivo, and ex vivo. These findings may have broad biomedical and clinical importance.

Published
2021

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