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The aim of this study was to compare self- perceived health between migraine and early stages of relapsing-remitting multiple sclerosis (RRMS) and to explore whether and how accurate those health domains predict overall quality of life. Methods: Ninety patients aged 18- 55 years were enrolled in this cross-sectional study. Thirty follow-up outpatients were recruited with migraine (with or without aura), 30 patients with RRMS, and 30 healthy subjects. They were asked to complete the Health status questionnaire (SF-36) and Personal Wellbeing Index (PWI). Results: Patients with RRMS and migraine had significantly worse self-reported health regarding role limitation due to physical problems and general health than the healthy control group. Additionally, migraine patients had more bodily pain, while RRMS patients expressed more difficulties regarding physical functioning. Differences between migraine and RRMS patients were not significant. Hierarchical regression analysis revealed that role limitation due to physical problems, mental health, and general health represents significant predictors of overall quality of life.Conclusions: Migraine may affect quality of life similarly to early stages of RRMS. Bio-psycho-socio-medical understanding of the two diseases and their impact on patients QoL should be reconsidered.

We present a patient with a clinically isolated syndrome suggestive of multiple sclerosis, who developed a full-blown picture of paranoid psychosis with suicidal attempt. Four new lesions were observed on brain MRI, one in the left and one in the right temporal lobe, one subcortically in the cingulate gyrus and one centrally in the tegmentum of the midbrain. The patient was treated with plasma exchange and recovered completely. Psychosis is not so rare symptom of multiple sclerosis as previously reported, and poses a major treatment challenge. A combination of lesions at strategic locations was a presumed mechanism of psychosis in this patient.

The aim of this investigation was to determine whether H.pylori infection is and indipendent risk factor for acute myocardial infarction, determine is there link between H.pylori infection and severity of disease, find is there link between H.pylori infection and well known risk factors for coronary heart disease. In this prospective, single centre study were enrolled 100 patients with acute myocardial infarction and control group was consisted 93 healthy individuals.. Analyzed risk factors included hypertension, diabetes, hyperlipidaemia, obesity, gender and smoking. The results of this study showed that there was no difference between H.pylori seropositivity distribution in the investigate and control group ( 29 vs. 26 % ), there was no significant difference on the severity of the disease according to the H.pylori seropositivity and there was no significant differencies on the association of H.pylori infection and well known risk factors ( hypertension, obesity ). There was significant association between H.pylori infection and acute myocardial infarction in the patients with three and more risk factors, where the patients with lower blood pressure ( 124, 4/77, 4 vs. 145, 9/87, 7 mmHg ) and better controled diabetes ( HbA1c 6, 1 % vs. 6, 9 % ) had greater risk for myocardial infarction if they are H.pylori seropositive. The large multicentric trials would be needed to define a precise role of H.pylori infection on the developement of acute myocardial infarction, esspecialy in the high risk patients.

The purpose of this investigation was to determine the atherosclerotic changes in patients with vascular parkinsonism and in patients with idiopathic Parkinson’s disease, in order to evaluate the possible influence of the extracranial pathology of carotid arteries in developing lacunar cerebral infarcts. Degree of stenosis and plaque morphology of the extracranial part of carotids in both group of patients were evaluated by color Doppler flow imaging ultrasound investigation and the results were compared. We selected two matched groups of patients with parkinsonism: 22 patients with vascular parkinsonism, and 28 with idiopathic Parkinson’s disease.The atherosclerotic changes found in patients with Parkinson’s disease showed mild carotid lesions with mostly stable calcified plaques and lesser risk for embolic cerebral intravascular events contrary to the higher degree of carotid stenosis found in patients with vascular parkinsonism with mostly mixed plaques prone to embolization. Therefore, we suggest performing ultrasonographic examination of the extracranial part of carotid arteries in all patients with parkinsonism to assess risk of vascular accidents originating from carotid lesions. That would enable adequate treatment of parkinsonism and prevent further occurrence of intracranial vascular changes.