1. Risk factors for Cesarean delivery in pregnancy with small‐for‐gestational‐age fetus undergoing induction of labor
- Author
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Leah Bagiardi, Anthony Odibo, Rachel G. Sinkey, Chinedu Nwabuobi, Niraj Gowda, Michelle Kuznicki, Linda Odibo, Jourdan E. Schmitz, Hannah Camisasca-Lopina, Nicole Wood, and Anaisy Pargas
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Gestational Age ,Risk Assessment ,Sensitivity and Specificity ,Likelihood ratios in diagnostic testing ,03 medical and health sciences ,Fetal Heart ,0302 clinical medicine ,Predictive Value of Tests ,Pregnancy ,Risk Factors ,Clinical Decision Rules ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Labor, Induced ,030212 general & internal medicine ,reproductive and urinary physiology ,Retrospective Studies ,Fetus ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,Cesarean Section ,business.industry ,Obstetrics ,Infant, Newborn ,Reproducibility of Results ,Obstetrics and Gynecology ,Gestational age ,Retrospective cohort study ,General Medicine ,medicine.disease ,Obstetric Labor Complications ,Fetal Diseases ,Fetal Weight ,Reproductive Medicine ,Area Under Curve ,Labor induction ,Infant, Small for Gestational Age ,Gestation ,Small for gestational age ,Female ,business ,Maternal Age - Abstract
Objectives To identify risk factors for Cesarean delivery and non-reassuring fetal heart tracing (NRFHT) in pregnancies with a small-for-gestational-age (SGA) fetus undergoing induction of labor and to design and validate a prediction model, combining antenatal and intrapartum variables known at the time of labor induction, to identify pregnancies at increased risk of Cesarean delivery. Methods This was a retrospective cohort study of non-anomalous, singleton gestations with a SGA fetus that underwent induction of labor, delivered in a single tertiary referral center between January 2011 and December 2016. SGA was defined as estimated fetal weight (EFW) Results A total of 594 pregnancies were included. Cesarean delivery was performed in 243 (40.9%) pregnancies. Significant risk factors associated with Cesarean delivery, and included in the final model, were maternal age, gestational age at delivery and initial method of labor induction. The bootstrap estimate of the AUC of the final prediction model for Cesarean delivery was 0.82 (95% CI, 0.78-0.86). The model had sensitivity of 64.2%, specificity of 86.9%, positive likelihood ratio (LR) of 4.9 and negative LR of 0.41. The model had good fit (P = 0.617). NRFHT complicated 117 (19.7%) pregnancies. Significant risk factors for NRFHT included EFW 95th percentile or absent/reversed end-diastolic flow) and gestational age at delivery. The final prediction model for NRFHT had an AUC of 0.69 (95% CI, 0.63-0.75) and specificity of 97.0%. Conclusion We identified several significant risk factors for Cesarean delivery and NRFHT among SGA pregnancies undergoing induction of labor. Clinicians may use these risk factors to guide patient counseling and to help anticipate the potential need for operative delivery. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
- Published
- 2020
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