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WOS: 000454426900019, A 2.5 years old male Golden Retriever breed dog with the itching, runny eyes, and continuous unease complaints was brought to a private veterinary medical centre in the Thrace region of Turkey, in September 2017. It was observed that there was a purulent conjunctivitis in the left eye and there was a mobile structure under the membrane nictitans after the examination. A drop of local anesthetic was dripped into the eye, and the mobile structure was removed with the help of a forceps. This removed structure was taken into the solution of 70% alcohol on suspicion of parasite. Both the extracted material and the blood samples were sent to the Department of Internal Medicine, Afyon Kocatepe University, Faculty of Veterinary Medicine for evaluation and it was evaluated with parasitologist. The parasite was cleared by taken into a 0.9% physiological saline and kept in the lactophenol for two days for transparency. Then, the transparent parasite was determined as Thelazia callipaeda after microscopic examination. The ocular form of thelaziasis caused by T. callipaeda in a dog has been reported for the first time in Turkey with this case report. By this report, first case of ocular thelaziasis reported seen a dog in Turkey and it was aimed to point out that this parasite can lead to significant eye problems in animals.

WOS: 000435091000007, PubMed ID: 30814888, Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. Thus, we examined the possible role of ceranib-2, a novel ceramidase inhibitor, on growth and apoptotic mechanisms of the human normal glia cell line (HNA), human glioma cell lines (T-98G and U-87MG), and a rat glioma cell line (C6). We also compared the results with the effects of C2 ceramide and cisplatin. We determined the in vitro survival rate with MTT assay, apoptosis with flow cytometry, gene expressions with qRT-PCR, and statistical significance by one-way analysis of variance together with Tukey's test. Calculated from MTT outcomes, the inhibitory ranking was as follows: T-98G > U-87MG > C6 > HNA. Ceranib-2 had the most growth-suppressive activity on human T-98G cells with an IC50 of 7 mu M for 24 h and 0.9 mu M for 48 h. Only the 25 mu M dose of ceranib-2 induced apoptosis of human T-98G and U-87MG cells after 24 h of treatment; however, it increased apoptosis of C6 cells dose- and time-dependently. Ceranib-2 increased the cytochrome c gene expression level during 24 h in T-98G cells. Ceranib-2 had cytotoxic and apoptotic effects on glioma cells but the cytotoxic effect was weaker on normal glia cells. 'Ibis cytotoxicity was stronger than that of C2 ceramide and cisplatin., Eskisehir Osmangazi University Scientific Research Projects Committee [2012/11032], This study was presented at the Joint Meeting of the Federation of European Physiological Societies and the Baltic Physiological Societies (FEPS), Kaunas, Lithuania on 26-29 August 2015, and in National Application Congress of Biological Sciences, 26-29 December 2016, Konya, Turkey. This study was funded by the Eskisehir Osmangazi University Scientific Research Projects Committee (grant number 2012/11032).

WOS: 000453220100057, …

WOS: 000336702000022, The taxonomic status of Scorzonera pygmaea var. pygmaea and var. nutans belonging to the tribe. cichoreae (Asteraceae). S. pygmaea samples were collected from Arayit mountain. We suggest that these two subspecies should be classified as varietes because of their morphological and anatomical characteristics, ecological and geographical similarities. Moreover being together in the same localities of these under species taxa supports our opinion, i.e. S. pygmaea Sibth. & Sm. var. pygmaea stat. nov. and S. pygmaea Sibth. & Sm. var. nutans (Czeczott) O. Koyuncu & Yaylaci, slat. nov., Eskisehir Osmangazi University Scientific Research Projects Commission (Project name: Gunyuzu (Eskisehir) ve Cevresinin Tohumlu Bitkiler); Karayosunu; Liken Florasi ye Etnobotanik Ozelliklerinin Belirlenmesi ile Bazi Tohumlu Bitkilerin Polen Morfolojileri Uzerinde Calismalar (In Turkish) [2010/19029], This study was supported by Eskisehir Osmangazi University Scientific Research Projects Commission (Project name: Gunyuzu (Eskisehir) ve Cevresinin Tohumlu Bitkiler, Karayosunu, Liken Florasi ye Etnobotanik Ozelliklerinin Belirlenmesi ile Bazi Tohumlu Bitkilerin Polen Morfolojileri Uzerinde Calismalar (In Turkish). Project Number: 2010/19029).