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1. Matched-Pair Analysis of Transplant from Haploidentical, Unmanipulated Bone Marrow Donor versus HLA Identical Sibling for Patients with Hematologic Malignancies

Author

Arcese, William, Cerretti, Raffaella, Sarmati, Loredana, Cudillo, Laura, De Angelis, Gottardo, Mariotti, Benedetta, Bruno, Antoine, Mangione, Ilaria, Rapanotti, Cristina, Andreani, Marco, De Fabritiis, Paolo, Dentamaro, Teresa, Cupelli, Luca, Mengarelli, Andrea, Marchesi, Francesco, Tirindelli, Maria Cristina, Annibali, Ombretta, Tafuri, Agostino, Ferrari, Antonella, Cedrone, Michele, Anaclerico, Barbara, Adorno, Gaspare, Miccichè, Silvia, Andreoni, Massimo, and Picardi, Alessandra

Published
2020
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2. P971: EFFECT OF DARATUMUMAB ON STEM CELL YIELDS IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: REPORT FROM THE MULTIPLE MYELOMA LAZIO GROUP.

Author

Fazio, Francesca, primary, Passucci, Mauro, additional, Lisi, Chiara, additional, Micozzi, Jacopo, additional, Fianchi, Luana, additional, Landro, Francesca DI, additional, Za, Tommaso, additional, Gumenyuk, Svitlana, additional, Ferraro, Silvia, additional, Anaclerico, Barbara, additional, De Padue, Laura, additional, Annibali, Ombretta, additional, Rago, Angela, additional, Piciocchi, Alfonso, additional, Bongarzoni, Velia, additional, Cupelli, Luca, additional, Mengarelli, Andrea, additional, De Stefano, Valerio, additional, Martelli, Maurizio, additional, and Petrucci, Maria-Teresa, additional

Published
2023
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3. Life for patients with myelofibrosis: the physical, emotional and financial impact, collected using narrative medicine—Results from the Italian 'Back to Life' project

Author

Palandri, Francesca, Benevolo, Giulia, Iurlo, Alessandra, Abruzzese, Elisabetta, Carella, Angelo M., Paoli, Chiara, Palumbo, Giuseppe A., Bonifacio, Massimiliano, Cilloni, Daniela, Andriani, Alessandro, Guarini, Attilio, Turri, Diamante, Elli, Elena Maria, Falcone, Antonietta, Anaclerico, Barbara, Musto, Pellegrino, Di Renzo, Nicola, Tiribelli, Mario, Zambello, Renato, Spinosa, Caterina, Ricco, Alessandra, Raucci, Letizia, Martino, Bruno, Annunziata, Mario, Pascale, Silvia, Liberati, Anna Marina, La Nasa, Giorgio, Maffioli, Margherita, Breccia, Massimo, Pugliese, Novella, Betti, Silvia, Giglio, Gianfranco, Cappuccio, Antonietta, and Reale, Luigi

Published
2018

4. Ruxolitinib in clinical practice for primary and secondary myelofibrosis: an analysis of safety and efficacy of Gruppo Laziale of Ph-negative MPN

Author

Breccia, Massimo, Andriani, Alessandro, Montanaro, Marco, Abruzzese, Elisabetta, Buccisano, Francesco, Cedrone, Michele, Centra, Antonietta, Villivà, Nicoletta, Celesti, Francesca, Trawinska, Malgorzata Monica, Massaro, Fulvio, Di Veroli, Ambra, Anaclerico, Barbara, Colafigli, Gioia, Molica, Matteo, Spadea, Antonio, Petriccione, Luca, Cimino, Giuseppe, and Latagliata, Roberto

Published
2017
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5. Spleen enlargement is a risk factor for thrombosis in essential thrombocythemia: Evaluation on 1,297 patients

Author

Andriani, Alessandro, Latagliata, Roberto, Anaclerico, Barbara, Spadea, Antonio, Rago, Angela, Di Veroli, Ambra, Spirito, Francesca, Porrini, Raffaele, De Muro, Marianna, Leonetti, Sabrina Crescenzi, Villivà, Nicoletta, De Gregoris, Cinzia, Montefusco, Enrico, Polverelli, Nicola, Santoro, Cristina, Breccia, Massimo, Cimino, Giuseppe, Majolino, Ignazio, Mazzucconi, Maria Gabriella, Vianelli, Nicola, Alimena, Giuliana, Montanaro, Marco, and Palandri, Francesca

Published
2016
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6. Symptomatic Mucocutaneous Toxicity of Hydroxyurea in Philadelphia Chromosome–Negative Myeloproliferative Neoplasms: The Mister Hyde Face of a Safe Drug

Author

Latagliata, Roberto, Spadea, Antonio, Cedrone, Michele, Di Giandomenico, Jonny, De Muro, Marianna, Villivà, Nicoletta, Breccia, Massimo, Anaclerico, Barbara, Porrini, Raffaele, Spirito, Francesca, Rago, Angela, Avvisati, Giuseppe, Alimena, Giuliana, Montanaro, Marco, and Andriani, Alessandro

Published
2012
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7. Anagrelide in Essential Thrombocythemia (ET): Results from 150 patients over 25 years by the “Ph1‐negative Myeloproliferative Neoplasms Latium Group”

Author

Mazzucconi, Maria Gabriella, primary, Baldacci, Ermina, additional, Latagliata, Roberto, additional, Breccia, Massimo, additional, Paoloni, Francesca, additional, Di Veroli, Ambra, additional, Cedrone, Michele, additional, Anaclerico, Barbara, additional, Villivà, Nicoletta, additional, Porrini, Raffaele, additional, Montefusco, Enrico, additional, Andriani, Alessandro, additional, Montanaro, Marco, additional, Scaramucci, Laura, additional, Spadea, Antonio, additional, Rago, Angela, additional, Cimino, Giuseppe, additional, Spirito, Francesca, additional, and Santoro, Cristina, additional

Published
2020
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9. Prognostic factors for thrombosis-free survival and overall survival in polycythemia vera: A retrospective analysis of 623 PTS With long follow-up

Author

Di Veroli, Ambra, Buccisano, Francesco, Andriani, Alessandro, Montanaro, Marco, Latagliata, Roberto, Santoro, Cristina, Breccia, Massimo, Spirito, Francesca, Cedrone, Michele, Anaclerico, Barbara, Leonetti Crescenzi, Sabrina, Porrini, Raffaele, De Muro, Marianna, Avvisati, Giuseppe, Tafuri, Agostino, Cimino, Giuseppe, and Spadea, Antonio

Published
2018
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10. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, Giuseppe, Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Milone, G., Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, Placanica, Paola, Girmenia, C, Bertaina, A, Piciocchi, A, Perruccio, K, Algarotti, A, Busca, A, Cattaneo, C, Raiola, Am, Guidi, S, Iori, Ap, Candoni, A, Irrera, G, Milone, G, Marcacci, G, Scimè, R, Musso, M, Cudillo, L, Sica, S, Castagna, L, Corradini, P, Marchesi, F, Pastore, D, Alessandrino, Ep, Annaloro, C, Ciceri, F, Santarone, S, Nassi, L, Farina, C, Viscoli, C, Rossolini, Gm, Bonifazi, F, Rambaldi, A, for the Gruppo Italiano Trapianto di Midollo Osseo, (GITMO), Associazione Microbiologi Clinici Italiani, (AMCLI), Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, G., Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, and Placanica, Paola

Subjects
0301 basic medicine, Male, Transplantation Conditioning, Drug Resistance, Bacteremia, 0302 clinical medicine, epidemiology, Gram negative bacteremia, multidrug resistance, stem cell transplant, survival, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Age Factor, Prospective Studies, Prospective cohort study, Child, Transplantation, Homologou, education.field_of_study, Incidence (epidemiology), Incidence, Bacterial, Age Factors, Hematopoietic Stem Cell Transplantation, Middle Aged, Transplantation, Autologou, surgical procedures, operative, Infectious Diseases, Italy, Child, Preschool, Female, medicine.symptom, Multiple, Autologous, Human, Homologous, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Transplantation, Autologous, 03 medical and health sciences, Young Adult, Internal medicine, Gram-Negative Bacteria, Gram-Negative Bacterial Infection, Escherichia coli, Humans, Transplantation, Homologous, Preschool, education, Aged, Gram-Negative Bacterial Infections, Infant, Transplantation, business.industry, Risk Factor, medicine.disease, Prospective Studie, Carriage, Otitis, business, Settore MED/15 - Malattie del Sangue, 030215 immunology
Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

11. Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1/AF4 and of the BCR/ABL fusion genes correlates with a significantly better clinical outcome

Author

Cimino, Giuseppe, Elia, Loredana, Mancini, Marco, Annino, Luciana, Anaclerico, Barbara, Fazi, Paola, Vitale, Antonella, Specchia, Giorgina, Di Raimondo, Francesco, Recchia, Anna, Cuneo, Antonio, Mecucci, Cristina, Pane, Fabrizio, Saglio, Giuseppe, Foà, Robin, and Mandelli, Franco

Published
2003
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12. Treatment of Philadelphia‐negative myeloproliferative neoplasms in accelerated/blastic phase with azacytidine. Clinical results and identification of prognostic factors

Author

Andriani, Alessandro, primary, Elli, Elena, additional, Trapè, Giulio, additional, Villivà, Nicoletta, additional, Fianchi, Luana, additional, Di Veroli, Ambra, additional, Niscola, Pasquale, additional, Centra, Antonia, additional, Anaclerico, Barbara, additional, Montanaro, Guido, additional, Martini, Vincenza, additional, Aroldi, Andrea, additional, Carmosino, Ida, additional, Voso, Maria Teresa, additional, Breccia, Massimo, additional, Montanaro, Marco, additional, Foà, Roberto, additional, and Latagliata, Roberto, additional

Published
2019
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13. High platelet count at diagnosis is a protective factor for thrombosis in patients with essential thrombocythemia

Author

Latagliata, Roberto, primary, Montanaro, Marco, additional, Cedrone, Michele, additional, Di Veroli, Ambra, additional, Spirito, Francesca, additional, Santoro, Cristina, additional, Leonetti Crescenzi, Sabrina, additional, Porrini, Raffaele, additional, Di Giandomenico, Jonny, additional, Villivà, Nicoletta, additional, Spadea, Antonio, additional, Rago, Angela, additional, De Gregoris, Cinzia, additional, Romano, Atelda, additional, Anaclerico, Barbara, additional, De Muro, Marianna, additional, Felici, Stefano, additional, Breccia, Massimo, additional, Montefusco, Enrico, additional, Bagnato, Antonino, additional, Cimino, Giuseppe, additional, Majolino, Ignazio, additional, Mazzucconi, Maria Gabriella, additional, Alimena, Giuliana, additional, and Andriani, Alessandro, additional

Published
2017
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14. Baseline factors associated with response to ruxolitinib: an independent study on 408 patients with myelofibrosis

Author

Palandri, Francesca, primary, Palumbo, Giuseppe Alberto, additional, Bonifacio, Massimiliano, additional, Tiribelli, Mario, additional, Benevolo, Giulia, additional, Martino, Bruno, additional, Abruzzese, Elisabetta, additional, D’Adda, Mariella, additional, Polverelli, Nicola, additional, Bergamaschi, Micaela, additional, Tieghi, Alessia, additional, Cavazzini, Francesco, additional, Ibatici, Adalberto, additional, Crugnola, Monica, additional, Bosi, Costanza, additional, Latagliata, Roberto, additional, Di Veroli, Ambra, additional, Scaffidi, Luigi, additional, de Marchi, Federico, additional, Cerqui, Elisa, additional, Anaclerico, Barbara, additional, De Matteis, Giovanna, additional, Spinsanti, Marco, additional, Sabattini, Elena, additional, Catani, Lucia, additional, Aversa, Franco, additional, Di Raimondo, Francesco, additional, Vitolo, Umberto, additional, Lemoli, Roberto Massimo, additional, Fanin, Renato, additional, Merli, Francesco, additional, Russo, Domenico, additional, Cuneo, Antonio, additional, Bacchi Reggiani, Maria Letizia, additional, Cavo, Michele, additional, Vianelli, Nicola, additional, and Breccia, Massimo, additional

Published
2017
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15. Role of treatment on the development of secondary malignancies in patients with essential thrombocythemia

Author

Santoro, Cristina, primary, Sperduti, Isabella, additional, Latagliata, Roberto, additional, Baldacci, Erminia, additional, Anaclerico, Barbara, additional, Avvisati, Giuseppe, additional, Breccia, Massimo, additional, Buccisano, Francesco, additional, Cedrone, Michele, additional, Cimino, Giuseppe, additional, De Gregoris, Cinzia, additional, De Muro, Marianna, additional, Di Veroli, Ambra, additional, Leonetti Crescenzi, Sabrina, additional, Montanaro, Marco, additional, Montefusco, Enrico, additional, Porrini, Raffaele, additional, Rago, Angela, additional, Spadea, Antonio, additional, Spirito, Francesca, additional, Villivà, Nicoletta, additional, Andriani, Alesssandro, additional, Alimena, Giuliana, additional, and Mazzucconi, Maria Gabriella, additional

Published
2017
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16. Incidence of Early Thrombosis in Myeloproliferative Neoplasms (MPN): A Prospective Analysis from the Gruppo Laziale of Ph-Negative MPN

Author

Di Veroli, Ambra, primary, De Muro, Marianna, additional, Andriani, Alessandro, additional, Trawinska, Malgorzata, additional, Rossi, Elena, additional, Santoro, Cristina, additional, Crescenzi Leonetti, Sabrina, additional, De Gregoris, Cinzia, additional, Romano, Atelda, additional, Petriccione, Luca, additional, D'Addosio, Ada, additional, Centra, Antonia, additional, Rauco, Annamaria, additional, Villivà, Nicoletta, additional, Anaclerico, Barbara, additional, Abruzzese, Elisabetta, additional, Breccia, Massimo, additional, Maurillo, Luca, additional, Alimena, Giuliana, additional, Ricci, Roberto, additional, De Stefano, Valerio, additional, Montanaro, Marco, additional, and Latagliata, Roberto, additional

Published
2016
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17. Young CML Patients Treated Frontline with Imatinib or Second Generation TKIs: Clinical Characteristics and Outcome

Author

Annunziata, Mario, primary, Latagliata, Roberto, additional, Iurlo, Alessandra, additional, Breccia, Massimo, additional, Capodanno, Isabella, additional, Baratè, Claudia, additional, Sorà, Federica, additional, Crisà, Elena, additional, Anaclerico, Barbara, additional, Isidori, Alessandro, additional, Sgherza, Nicola, additional, Gozzini, Antonella, additional, Russo, Sabina, additional, Avanzini, Paolo, additional, Musolino, Caterina, additional, Sica, Simona, additional, Cedrone, Michele, additional, Galimberti, Sara, additional, Ferrero, Dario, additional, Visani, Giuseppe, additional, Alimena, Giuliana, additional, Ferrara, Felicetto, additional, and Russo Rossi, Antonella, additional

Published
2016
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18. Latium (Italy) Epidemiology of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs) from 2011 to 2015: A Prospective Analysis from Gruppo Laziale of Ph Negative MPN

Author

De Muro, Marianna, primary, Di Veroli, Ambra, additional, Montanaro, Marco, additional, Latagliata, Roberto, additional, Santoro, Cristina, additional, Breccia, Massimo, additional, Cedrone, Michele, additional, Anaclerico, Barbara, additional, Trawinska, Malgorzata Monika, additional, Abruzzese, Elisabetta, additional, Rauco, Annamaria, additional, Leonetti Crescenzi, Sabrina, additional, Villivà, Nicoletta, additional, Cimino, Giuseppe, additional, Romano, Atelda, additional, Spadea, Antonio, additional, Rossi, Elena, additional, De Stefano, Valerio, additional, Petriccione, Luca, additional, D'Addosio, Ada, additional, Buccisano, Francesco, additional, Ricci, Roberto, additional, Alimena, Giuliana, additional, Avvisati, Giuseppe, additional, and Andriani, Alessandro, additional

Published
2016
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19. Predictors for Response to Ruxolitinib in Real-Life: An Observational Independent Study on 408 Patients with Myelofibrosis

Author

Palandri, Francesca, primary, Palumbo, Giuseppe A., additional, Bonifacio, Massimiliano, additional, Tiribelli, Mario, additional, Benevolo, Giulia, additional, Martino, Bruno, additional, Abruzzese, Elisabetta, additional, D'Adda, Mariella, additional, Polverelli, Nicola, additional, Bergamaschi, Micaela, additional, Tieghi, Alessia, additional, Cavazzini, Francesco, additional, Ibatici, Adalberto, additional, Crugnola, Monica, additional, Bosi, Costanza, additional, Latagliata, Roberto, additional, Di Veroli, Ambra, additional, Scaffidi, Luigi, additional, De Marchi, Federico, additional, Cerqui, Elisa, additional, Anaclerico, Barbara, additional, Di Raimondo, Francesco, additional, Vitolo, Umberto, additional, Lemoli, Roberto M, additional, Fanin, Renato, additional, Merli, Francesco, additional, Russo, Domenico, additional, Cuneo, Antonio, additional, Cavo, Michele, additional, Vianelli, Nicola, additional, and Breccia, Massimo, additional

Published
2016
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20. Essential Thrombocythemia: A Comparison of Overall and Thrombosis Free Survival in Two Discrete Periods of the First Decade of 2000. a Retrospective Analysis

Author

Montanaro, Marco, primary, Di Veroli, Ambra, additional, De Muro, Marianna, additional, Santoro, Cristina, additional, Breccia, Massimo, additional, Cedrone, Michele, additional, Anaclerico, Barbara, additional, Trawinska, Malgorzata Monika, additional, Porrini, Raffaele, additional, Abruzzese, Elisabetta, additional, Leonetti Crescenzi, Sabrina, additional, Villivà, Nicoletta, additional, Cimino, Giuseppe, additional, Romano, Atelda, additional, Spirito, Francesca, additional, Spadea, Antonio, additional, Tafuri, Agostino, additional, Buccisano, Francesco, additional, Ricci, Roberto, additional, Lo Coco, Francesco, additional, Alimena, Giuliana, additional, Latagliata, Roberto, additional, and Andriani, Alessandro, additional

Published
2016
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21. Efficacy and Safety of Ruxolitinib in Elderly Patients (> 75 years) with Myelofibrosis

Author

Latagliata, Roberto, primary, Di Veroli, Ambra, additional, Palumbo, Giuseppe Alberto, additional, Bonifacio, Massimiliano, additional, Andriani, Alessandro, additional, Polverelli, Nicola, additional, Trawinska, Malgorzata, additional, Tiribelli, Mario, additional, Anaclerico, Barbara, additional, Benevolo, Giulia, additional, Petriccione, Luca, additional, Martino, Bruno, additional, Centra, Antonia, additional, D'Adda, Mariella, additional, Crugnola, Monica, additional, Cavazzini, Francesco, additional, Bergamaschi, Micaela, additional, Tieghi, Alessia, additional, Ibatici, Adalberto, additional, Bosi, Costanza, additional, Perricone, Margherita, additional, Montanaro, Marco, additional, Cavo, Michele, additional, Breccia, Massimo, additional, Vianelli, Nicola, additional, and Palandri, Francesca, additional

Published
2016
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22. Ruxolitinib in clinical practice for primary and secondary myelofibrosis: an analysis of safety and efficacy of Gruppo Laziale of Ph-negative MPN

Author

Breccia, Massimo, primary, Andriani, Alessandro, additional, Montanaro, Marco, additional, Abruzzese, Elisabetta, additional, Buccisano, Francesco, additional, Cedrone, Michele, additional, Centra, Antonietta, additional, Villivà, Nicoletta, additional, Celesti, Francesca, additional, Trawinska, Malgorzata Monica, additional, Massaro, Fulvio, additional, Di Veroli, Ambra, additional, Anaclerico, Barbara, additional, Colafigli, Gioia, additional, Molica, Matteo, additional, Spadea, Antonio, additional, Petriccione, Luca, additional, Cimino, Giuseppe, additional, and Latagliata, Roberto, additional

Published
2016
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23. EBMT 2015 The Impact of HLA Matching on the Clinical Outcome of Hematopoietic Stem Cell Transplantation from Volunteer Unrelated Donors According to the Uniform, Prospective Transplant Program of the Rome Transplant Network 22 - 25 March 2015 • Istanbul, Turkey

Author

Picardi, Alessandra, Cudillo, Laura, Mangione, Ilaria, Angelis, Gottardo De, Mariotti, Benedetta, Piazza, Fabio Di, Cantonetti, Maria, Ceresoli, Eleonora, Rapanotti, Cristina, Fabritiis, Paolo De, Dentamaro, Teresa, Tirindelli, Maria Cristina, Annibali, Ombretta, Mengarelli, Andrea, Marchesi, Francesco, Chierichini, Anna, Anaclerico, Barbara, Montefusco, Enrico, Ferrari, Antonella, Andreani, Marco, Testi, Manuela, Arcese, William, On Behalf Of Rome Transplant Network. 1Hematology Division-Stem Cell Transplant Unit, TOR VERGATA UNIVERSITY OF ROME, S.Eugenio Hospital, Institute, Regina Elena National Cancer, S.Giovanni Addolorata, S.Andrea Hospital, Transplant Biology, IME Foundation, Rome, and Italy

Published
2015
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24. Application of the International Prognostic Score of Thrombosis for Essential Thrombocytemia(ET) (IPSET-Thrombosis) in a Cohort of ET Patients: Experience from Gruppo Laziale for Myeloproliferative Ph Negative Neoplasms

Author

Cedrone, Michele, primary, Anaclerico, Barbara, additional, Paoloni, Francesca, additional, Latagliata, Roberto, additional, Montanaro, Marco, additional, Spirito, Francesca, additional, Leonetti Crescenzi, Sabrina, additional, Spadea, Antonio, additional, Porrini, Raffaele, additional, Rago, Angela, additional, Breccia, Massimo, additional, De Gregoris, Cinzia, additional, Cimino, Giuseppe, additional, Montefusco, Enrico, additional, Tafuri, Agostino, additional, Avvisati, Giuseppe, additional, Majolino, Ignazio, additional, Lo Coco, Francesco, additional, Santoro, Cristina, additional, Mazzucconi, Maria Gabriella, additional, Ruscio, Carla, additional, De Muro, Marianna, additional, Alimena, Giuliana, additional, Andriani, Alessandro, additional, Bagnato, Antonino, additional, and Annino, Luciana, additional

Published
2015
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25. The Platelet COUNT at Diagnosis of Essential Thrombocythemia Is a Prognostic Factor for Thrombosis-Free Survival: Retrospective Analysis on 1201 Patients

Author

Montanaro, Marco, primary, Latagliata, Roberto, additional, Cedrone, Michele, additional, Di Veroli, Ambra, additional, Santoro, Cristina, additional, Spirito, Francesca, additional, Ruscio, Carla, additional, Leonetti-Crescenzi, Sabrina, additional, Porrini, Raffaele, additional, Di Giandomenico, Jonny, additional, Villivà, Nicoletta, additional, Spadea, Antonio, additional, Rago, Angela, additional, De Gregoris, Cinzia, additional, Cercola, Paolo, additional, Anaclerico, Barbara, additional, De Muro, Marianna, additional, Felici, Stefano, additional, Breccia, Massimo, additional, Montefusco, Enrico, additional, Bagnato, Antonino, additional, Cimino, Giuseppe, additional, Majolino, Ignazio, additional, Mazzucconi, Maria Gabriella, additional, Alimena, Giuliana, additional, and Andriani, Alessandro, additional

Published
2015
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26. Evolving Criteria of Donor Selection for Allogeneic Transplant in Acute Myeloid Leukemia

Author

Arcese, William, primary, Cerretti, Raffaella, additional, Cudillo, Laura, additional, De Angelis, Gottardo, additional, Mariotti, Benedetta, additional, Venditti, Adriano, additional, Buccisano, Francesco, additional, Cantonetti, Maria, additional, Mangione, Ilaria, additional, Andreani, Marco, additional, Testi, Manuela, additional, De Fabritiis, Paolo, additional, Dentamaro, Teresa, additional, Cupelli, Luca, additional, Tendas, Andrea, additional, Avvisati, Giuseppe, additional, Tirindelli, Maria Cristina, additional, Annibali, Ombretta, additional, Mengarelli, Andrea, additional, Marchesi, Francesco, additional, Romano, Atelda, additional, Chierichini, Anna, additional, Anaclerico, Barbara, additional, Tafuri, Agostino, additional, Ferrari, Antonella, additional, Naso, Virginia, additional, Miccichè, Silvia, additional, Di Piazza, Fabio, additional, Lo Coco, Francesco, additional, Amadori, Sergio, additional, and Picardi, Alessandra, additional

Published
2015
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27. Are ET and PV Patients Two Similar Populations As Concern Thrombotic Risk Factors?

Author

Andriani, Alessandro, primary, Latagliata, Roberto, additional, Cedrone, Michele, additional, Di Veroli, Ambra, additional, Santoro, Cristina, additional, Spirito, Francesca, additional, Ruscio, Carla, additional, Crescenzi-Leonetti, Sabrina, additional, Porrini, Raffaele, additional, Di Giandomenico, Jonny, additional, Villivà, Nicoletta, additional, Spadea, Antonio, additional, Rago, Angela, additional, De Gregoris, Cinzia, additional, Cercola, Paolo, additional, Anaclerico, Barbara, additional, De Muro, Marianna, additional, Felici, Stefano, additional, Breccia, Massimo, additional, Montefusco, Enrico, additional, Bagnato, Antonino, additional, Cimino, Giuseppe, additional, Majolino, Ignazio, additional, Mazzucconi, Maria Gabriella, additional, Alimena, Giuliana, additional, and Montanaro, Marco, additional

Published
2015
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28. Survival of Patients with High Risk Hematological Malignancy after Allogeneic Transplant from HLA Identical Siblings Is Comparable to That of Patients Transplanted from Haploidentical, Unmanipulated Bone Marrow Donor: Results of a Matched-Pair Analysis from the Rome Transplant Network

Author

Arcese, William, primary, Cerretti, Raffaella, additional, Cudillo, Laura, additional, De Angelis, Gottardo, additional, Picardi, Alessandra, additional, de Fabritiis, Paolo, additional, Dentamaro, Teresa, additional, Tendas, Andrea, additional, Cupelli, Luca, additional, Mengarelli, Andrea, additional, Marchesi, Francesco, additional, Chierichini, Anna, additional, Anaclerico, Barbara, additional, Tirindelli, Maria Cristina, additional, Cerchiara, Elisabetta, additional, Montefusco, Enrico, additional, Ferrari, Antonella, additional, Mariotti, Benedetta, additional, Ceresoli, Eleonora, additional, Adorno, Gaspare, additional, Di Piazza, Fabio, additional, Gentile, Giuseppe, additional, and Sarmati, Loredana, additional

Published
2014
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29. Prognostic Factors for Thrombosis-Free Survival and Overall Survival in Polycytemia Vera: A Retrospective Analysis of 623 Patients Series with Long Follow-up

Author

Andriani, Alessandro, primary, Latagliata, Roberto, additional, Cedrone, Michele, additional, Diveroli, Ambra, additional, Spirito, Francesca, additional, Ruscio, Carla, additional, Leonetti Crescenzi, Sabrina, additional, Porrini, Raffaele, additional, Di Giandomenico, Jonny, additional, Villivà, Nicoletta, additional, Spadea, Antonio, additional, Rago, Angela, additional, De Gregoris, Cinzia, additional, Pessina, Gloria, additional, De Muro, Marianna, additional, Felici, Stefano, additional, Breccia, Massimo, additional, Montefusco, Enrico, additional, Bagnato, Antonino, additional, Anaclerico, Barbara, additional, Cimino, Giuseppe, additional, Majolino, Ignazio, additional, Alimena, Giuliana, additional, and Montanaro, Marco, additional

Published
2014
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30. Autopsy Analysis On Epidemiology and Site of Involvement Of Invasive Fungal Infections (IFI) In Hematological Malignancies : A Retrospective Study at Hematologic Tertiary Care Department

Author

Chierichini, Anna, primary, Monardo, Francesca, additional, Anaclerico, Barbara, additional, Borza, Paola Anticoli, additional, Bongarzoni, Velia, additional, Campagna, Domenico, additional, Cedrone, Michele, additional, Fenu, Susanna, additional, Norata, Marianna, additional, Paoloni, Francesca, additional, Ronci, Benedetto, additional, and Annino, Luciana, additional

Published
2013
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31. Prospective Phase II Single-Center Study of the Safety of a Single Very High Dose of Liposomal Amphotericin B for Antifungal Prophylaxis in Patients with Acute Myeloid Leukemia

Author

Annino, Luciana, primary, Chierichini, Anna, additional, Anaclerico, Barbara, additional, Finolezzi, Erica, additional, Norata, Marianna, additional, Cortese, Stefania, additional, Cassetta, Maria Iris, additional, Fallani, Stefania, additional, Novelli, Andrea, additional, and Girmenia, Corrado, additional

Published
2013
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32. The Role of Previous Thrombotic Events in Patients with Essential Thrombocythemia: The Earlier the Worse?

Author

Latagliata, Roberto, primary, Montanaro, Marco, additional, Cedrone, Michele, additional, Villivà, Nicoletta, additional, Porrini, Raffaele, additional, Spirito, Francesca, additional, Rago, Angela, additional, Crescenzi, Sabrina Leonetti, additional, Spadea, Antonio, additional, De Muro, Marianna, additional, Cotroneo, Ettore, additional, Breccia, Massimo, additional, Baldacci, Erminia, additional, De Gregoris, Cinzia, additional, Anaclerico, Barbara, additional, Felici, Stefano, additional, Ruscio, Carla, additional, Giandomenico, Jonny Di, additional, Franceschini, Luca, additional, Pessina, Gloria, additional, Cimino, Giuseppe, additional, Montefusco, Enrico, additional, Tafuri, Agostino, additional, Avvisati, Giuseppe, additional, Majolino, Ignazio, additional, Mazzucconi, Maria Gabriella, additional, Alimena, Giuliana, additional, and Andriani, Alessandro, additional

Published
2012
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33. Moderate/ Severe Pleural Effusion As a Side Effect in Very Old Chronic Myeloid Leukemia (CML) Patients Undergoing Imatinib Treatment

Author

Ferrero, Dario, primary, Latagliata, Roberto, additional, Trawinska, Malgorzata Monika, additional, Cavazzini, Francesco, additional, Gugliotta, Gabriele, additional, Breccia, Massimo, additional, Annunziata, Mario, additional, Vigneri, Paolo, additional, Tiribelli, Mario, additional, Binotto, Gianni, additional, Fava, Carmen, additional, Crisà, Elena, additional, Mansueto, Giovanna, additional, Gozzini, Antonella, additional, Cavalli, Laura, additional, Porrini, Raffaele, additional, Iurlo, Alessandra, additional, Russo, Sabina, additional, Anaclerico, Barbara, additional, Rossi, Antonella Russo, additional, Pregno, Patrizia, additional, Visani, Giuseppe, additional, Capodanno, Isabella, additional, Endri, Mauro, additional, Spadea, Antonio, additional, Giglio, Gianfranco, additional, Celesti, Francesca, additional, Sorà, Federica, additional, Storti, Sergio, additional, D’Addosio, Ada M, additional, Cambrin, Giovanna Rege, additional, Abruzzese, Elisabetta, additional, Rosti, Gianantonio, additional, Luciano, Luigiana, additional, and Alimena, Giuliana, additional

Published
2011
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34. Risk Factors for Thrombosis Vary According to Age in Patients with Essential Thrombocythemia: a Retrospective Analysis of 1090 Patients from the “Gruppo Laziale SMPC Ph Negative “,

Author

Montanaro, Marco, primary, Latagliata, Roberto, additional, Cedrone, Michele, additional, Villivà, Nicoletta, additional, Porrini, Raffaele, additional, Spirito, Francesca, additional, Rago, Angela, additional, Crescenzi, Sabrina Leonetti, additional, Spadea, Antonio, additional, De Muro, Marianna, additional, Cotroneo, Ettore, additional, Breccia, Massimo, additional, De Gregoris, Cinzia, additional, Anaclerico, Barbara, additional, Felici, Stefano, additional, Ruscio, Carla, additional, Di Giandomenico, Jonny, additional, Franceschini, Luca, additional, Pessina, Gloria, additional, Cimino, Giuseppe, additional, Montefusco, Enrico, additional, Majolino, Ignazio, additional, Mazzucconi, Maria Gabriella, additional, Alimena, Giuliana, additional, and Andriani, Alessandro, additional

Published
2011
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35. Clinical Follow-up of Patients with Myeloproliferative Neoplasms Presenting Skin Ulcers During Treatment with Hydroxyurea

Author

Latagliata, Roberto, primary, Cedrone, Michele, additional, Villivà, Nicoletta, additional, De Gregoris, Cinzia, additional, Breccia, Massimo, additional, Spadea, Antonio, additional, De Muro, Marianna, additional, Tafuri, Agostino, additional, Anaclerico, Barbara, additional, Felici, Stefano, additional, D'Andrea, Mariella, additional, Montefusco, Enrico, additional, Abruzzese, Elisabetta, additional, Spirito, Francesca, additional, Leonetti Crescenzi, Sabrina, additional, Recine, Umberto, additional, Mazzucconi, Maria Gabriella, additional, Annino, Luciana, additional, Cimino, Giuseppe, additional, Avvisati, Giuseppe, additional, Petti, Maria Concetta, additional, Alimena, Giuliana, additional, Montanaro, Marco, additional, and Andriani, Alessandro, additional

Published
2011
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36. A Retrospective Epidemiological Analysis of 1572 Cases of Ph1- Myeloprolypherative Neoplasms (MPNs) From 9 Centers In the Latium: Preliminary Results

Author

Montanaro, Marco, primary, Latagliata, Roberto, additional, Montefusco, Enrico, additional, Cedrone, Michele, additional, Villivà, Nicoletta, additional, Cotroneo, Ettore, additional, Rago, Angela, additional, Spirito, Francesca, additional, De Muro, Marianna, additional, Breccia, Massimo, additional, Anaclerico, Barbara, additional, Porrini, Raffaele, additional, Pessina, Gloria, additional, Felici, Stefano, additional, Trapè, Giulio, additional, Tafuri, Agostino, additional, Mazzucconi, Maria Gabriella, additional, Cimino, Giuseppe, additional, Majolino, Ignazio, additional, Avvisati, Giuseppe, additional, Lo Coco, Francesco, additional, and Andriani, Alessandro, additional

Published
2010
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37. Skin Toxicity of Hydroxyurea In Ph- Myeloproliferative Neoplasms: Incidence and Clinical Features

Author

Latagliata, Roberto, primary, Cedrone, Michele, additional, Villivà, Nicoletta, additional, Breccia, Massimo, additional, Anaclerico, Barbara, additional, Volpicelli, Paola, additional, Ferretti, Antonella, additional, Felici, Stefano, additional, Montefusco, Enrico, additional, Abruzzese, Elisabetta, additional, Spadea, Antonio, additional, Spirito, Francesca, additional, Cotroneo, Ettore, additional, De Muro, Marianna, additional, Annino, Luciana, additional, Cimino, Giuseppe, additional, Alimena, Giuliana, additional, Montanaro, Marco, additional, and Andriani, Alessandro, additional

Published
2010
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39. Standard Versus High Dose Lenograstim in Adults with Hematological Malignancies for Peripheral Blood Progenitor Cell Mobilization: Results of a Retrospective Study on Behalf of Rome Transplant Network.

Author

Romeo, Azzurra Anna, primary, Chierichini, Anna, primary, Giannarelli, Diana, primary, Spagnoli, Alessandra, primary, Anaclerico, Barbara, primary, Vittori, Mariangela, primary, Vacca, Michele, primary, Gozzer, Maria, primary, Spadea, Antonio, primary, Annino, Luciana, primary, Petti, Maria Concetta, primary, Mengarelli, Andrea, primary, and Arcese, William, primary

Published
2008
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41. Treatment with Sequential Valproic Acid (VPA) +/− Low Doses All Trans Retinoic Acid (LoATRA) and Low Doses Ara-C (LoDAC) for “De Novo” or Relapsed Acute Myeloid Leukaemia (AML).

Author

Fenu, Susanna, primary, Nervi, Clara, additional, Nobile, Carolina, additional, Chierichini, Anna, additional, Borza, Paola Anticoli, additional, Anaclerico, Barbara, additional, Bongarzoni, Velia, additional, Bove, Loredana, additional, Cortese, Stefania, additional, Pauselli, Fulivio, additional, Tozzi, Carla, additional, Vignetti, Su Ellen, additional, Cimino, Giuseppe G., additional, and Annino, Luciana, additional

Published
2007
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42. Safety and Tolerability of Intrathecal Liposomal Cytarabine during CNS Prophylaxis in Patients with Non Hodgkin Lymphoma and Acute Lymphoblastic Leukemia.

Author

Annino, Luciana, primary, Anaclerico, Barbara, additional, Benevolo, Giulia, additional, Cascavilla, Nicola, additional, Cimminiello, Michele, additional, Dell’Olio, Matteo, additional, Gagliardi, Alfredo, additional, Giordano, Giulio, additional, Miraglia, Eustachio, additional, Musso, Maurizio, additional, Parvis, Guido, additional, Piano, Silvia, additional, Pilatrino, Chiara, additional, Scalone, Renato, additional, Venditti, Adriano, additional, Venditti, Daniela, additional, Vitolo, Umberto, additional, and Storti, Sergio, additional

Published
2007
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44. Liposomal Cytarabine in the Central Nervous System (CNS) Prophylaxis of Elderly Patients with Aggressive B-Cell Non-Hodgkin’s Lymphoma (NHL) and Undifferentiated Acute Leukemia (UAL): Preliminary Results of a Single-Center Experience.

Author

Anaclerico, Barbara, primary, Bongarzoni, Velia, additional, Chierichini, Anna, additional, Bartolini, Maurizio, additional, Iacovino, Piero, additional, Fenu, Susanna, additional, Anticoli-Borza, Paola, additional, and Annino, Luciana, additional

Published
2006
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45. Diagnostic Approach to CD5+/CD23+ Leukemic Non-Hodgkin Lymphomas Lacking Lymphnode Histopathology.

Author

Giudice, Ilaria Del, primary, Anaclerico, Barbara, additional, De Propris, Maria Stefania, additional, Mancini, Francesca, additional, Pescarmona, Edoardo, additional, Bizzoni, Luisa, additional, Levi, Anna, additional, Calabrese, Elisabetta, additional, Pileri, Stefano, additional, Tafuri, Agostino, additional, Guarini, Anna, additional, and Foà, Robert, additional

Published
2005
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46. Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1/AF4and of the BCR/ABLfusion genes correlates with a significantly better clinical outcome

Author

Cimino, Giuseppe, Elia, Loredana, Mancini, Marco, Annino, Luciana, Anaclerico, Barbara, Fazi, Paola, Vitale, Antonella, Specchia, Giorgina, Di Raimondo, Francesco, Recchia, Anna, Cuneo, Antonio, Mecucci, Cristina, Pane, Fabrizio, Saglio, Giuseppe, Foà, Robin, and Mandelli, Franco

Abstract

To elucidate the biologic and clinical heterogeneity of adult pro-B acute lymphoblastic leukemia (ALL) (ie, terminal deoxynucletidyl-transferase–positive[TdT+], CD19+, CD10–, surface immunoglobulin–negative [SIg–]), we evaluated 66 patients enrolled in the Italian multicentric Gruppo Italiano Malattie Ematologiche dell’Adulto (GIMEMA) 0496 study between October 1996 and December 1999. The ALL1/AF4fusion transcript, originating from the t(4;11) translocation, was detected in 24 patients (36.4%), and the BCR/ABLchimeric product was found in 6 patients (9%), while the remaining 36 cases (54.6%) were ALL1/AF4-BCR/ABL–negative. A white blood cell (WBC) count higher than 50 × 109/L was found in 13 of 24, 2 of 6, and 6 of 36 of the ALL1/AF4-positive, BCR/ABL-positive, and ALL1/AF4-BCR/AB–negative patients, respectively (P= .007). None of the 24 ALL1/AF4-positive patients coexpressed the CD13 and/or CD33 myeloid antigens. By contrast, CD13 and CD33 molecules were detected, respectively, in 3 of 6 and in 14 of 33 cases of the BCR/ABL-positive patient group, and in 2 of 6 and 9 of 35 cases of the ALL1/AF4-BCR/ABL–negative patient group. These differences still remained statistically significant even if the BCR/ABL-positive patients were excluded from the analysis. A complete remission (CR) was achieved in 52 (83.4%) of the 62 patients with ALL evaluable for response to treatment. CR rates were similar in the 3 genotypic groups. By contrast, comparing patients with or without the ALL1/AF4gene the probability of remaining in continuous complete remission (CCR) at 3.5 years was 16% and 49.8%, respectively (P= .005). Our data demonstrate that in adult pro-B-ALL a distinction should be made between pro-B-ALL cases with and without the ALL1/AF4or the BCR/ABLchimeric genes, since the absence of both of these fusion genes correlates with a significantly better clinical outcome after intensive polychemotherapy treatment without hematopoietic stem cell transplantation.

Published
2003
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47. Incidence of Early Adverse Events in Primary Myelofibrosis (PMI). a Prospective Analysis from the Gruppo Laziale of Ph-Negative MPN

Author

Di Veroli, Ambra, Rossi, Elena, Breccia, Massimo, De Muro, Marianna, Villivà, Nicoletta, Trawinska, Malgorzata Monika, Crescenzi Leonetti, Sabrina, Montanaro, Guido, Romano, Atelda, Petriccione, Luca, D'Addosio, Ada, Centra, Antonia, Rauco, Annamaria, Anaclerico, Barbara, Abruzzese, Elisabetta, Maurillo, Luca, Carmosino, Ida, Montanaro, Marco, Andriani, Alessandro, De Stefano, Valerio, Foa, Robin, and Latagliata, Roberto

Abstract

Background.Adverse events are relatively more common in the follow-up of primary myelofibrosis (PMI) than in other Ph- myeloproliferative neoplasms, with higher morbidity and mortality rates, as reported in several retrospective studies. At present, however, prospective data on the early incidence (<4 years from diagnosis) of these complications in PMI are not available.

Published
2017
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48. Possible Role Of Treatment On Secondary Malignancies In Patients Affected By Essential Thrombocytemia

Author

Santoro, Cristina, Di Giandomenico, Jonny, De Muro, Marianna, Villivà, Nicoletta, Di Veroli, Ambra, Montanaro, Marco, Latagliata, Roberto, Anaclerico, Barbara, Avvisati, Giuseppe, Breccia, Massimo, Cedrone, Michele, Cimino, Giuseppe, Montanaro, Guido, Montefusco, Enrico, Felici, Stefano, Crescenzi, Sabrina Leonetti, Majolino, Ignazio, Porrini, Raffaele, Rago, Angela, Spadea, Antonio, Spirito, Francesca, Alimena, Giuliana, Mazzucconi, Maria Gabriella, and Andriani, Alessandro

Abstract

Survival of Essential Thrombocytemia (ET) patients in the first 10 years of disease follow-up is similar to the general population one. While it is well known that alkylating agents (given alone or sequentially) increase the risk for acute myeloid leukemia, the specific role of different therapies on the development of secondary malignancies (SM) in ET patients, is still under investigation.

Published
2013
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49. Azacitidine In The Treatment Of Ph- Myeloproliferative Neoplasms In Blastic Phase: The Experience Of Gruppo Laziale For The Study Of Ph- SMPC

Author

Andriani, Alessandro, Latagliata, Roberto, Voso, Maria Teresa, Villivà, Nicoletta, Ciccone, Fabrizio, Andrizzi, Cristina, De Gregoris, Cinzia, Buccisano, Francesco, De Blasio, Angelo, Anaclerico, Barbara, Avvisati, Giuseppe, Bagnato, Antonino, Cedrone, Michele, Cimino, Giuseppe, Majolino, Ignazio, Montefusco, Enrico, Spadea, Antonio, Alimena, Giuliana, and Montanaro, Marco

Abstract

Prognosis of patients with myeloproliferative neoplasms developing blast phase (MPN-BP) is very poor. Median survival of these patients is about 2-3 months (Cervantes F, Acta Hemathol 1991; Mesa RA, Blood 2005; Kantajian HM, Leukemia 1997; Tam CS, Blood 2008) and nowadays no drug can induce a durable complete response (CR) in patients who are not candidate to BMT. A phase II study (Thepot S., Blood 2010, 116, 3735) recently reported on 54 patients with MPN-BP treated with 5-AZA, showing a median survival of 9 months with an Overall Response Rate (ORR) of 52% (24% complete response).

Published
2013
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50. Baseline factors associated with response to ruxolitinib: An independent study on 408 patients with myelofibrosis

Author

Micaela Bergamaschi, Alessia Tieghi, Bruno Martino, Monica Crugnola, Massimo Breccia, Adalberto Ibatici, Nicola Vianelli, Massimiliano Bonifacio, Giulia Benevolo, Mariella D'Adda, Barbara Anaclerico, Michele Cavo, Marco Spinsanti, Elisa Cerqui, Roberto Latagliata, Francesco Cavazzini, Elisabetta Abruzzese, Giuseppe A. Palumbo, Federico De Marchi, Giovanna De Matteis, Costanza Bosi, Roberto M. Lemoli, Franco Aversa, Elena Sabattini, Ambra Di Veroli, Francesco Di Raimondo, Renato Fanin, Luigi Scaffidi, Maria Letizia Bacchi Reggiani, Antonio Cuneo, Domenico Russo, Mario Tiribelli, Lucia Catani, Francesca Palandri, Umberto Vitolo, Nicola Polverelli, Francesco Merli, Palandri, Francesca, Palumbo, Giuseppe Alberto, Bonifacio, Massimiliano, Tiribelli, Mario, Benevolo, Giulia, Martino, Bruno, Abruzzese, Elisabetta, D'Adda, Mariella, Polverelli, Nicola, Bergamaschi, Micaela, Tieghi, Alessia, Cavazzini, Francesco, Ibatici, Adalberto, Crugnola, Monica, Bosi, Costanza, Latagliata, Roberto, Di Veroli, Ambra, Scaffidi, Luigi, de Marchi, Federico, Cerqui, Elisa, Anaclerico, Barbara, De Matteis, Giovanna, Spinsanti, Marco, Sabattini, Elena, Catani, Lucia, Aversa, Franco, Di Raimondo, Francesco, Vitolo, Umberto, Lemoli, Roberto Massimo, Fanin, Renato, Merli, Francesco, Russo, Domenico, Cuneo, Antonio, Bacchi Reggiani, Maria Letizia, Cavo, Michele, Vianelli, Nicola, and Breccia, Massimo

Subjects
medicine.medical_specialty, Ruxolitinib, Bone marrow transplant, Socio-culturale, Myelofibrosis, Clinical biochemistry, predictive factor, 03 medical and health sciences, 0302 clinical medicine, Disease severity, myelofibrosi, Internal medicine, medicine, myelofibrosis, predictive factors, response, ruxolitinib, splenomegaly, Hematology, business.industry, Response, University hospital, medicine.disease, Transplantation, Oncology, 030220 oncology & carcinogenesis, Splenomegaly, Predictive factors, Clinical Research Paper, business, 030215 immunology, medicine.drug
Abstract

// Francesca Palandri 1 , Giuseppe Alberto Palumbo 2 , Massimiliano Bonifacio 3 , Mario Tiribelli 4 , Giulia Benevolo 5 , Bruno Martino 6 , Elisabetta Abruzzese 7 , Mariella D’Adda 8 , Nicola Polverelli 9 , Micaela Bergamaschi 10 , Alessia Tieghi 11 , Francesco Cavazzini 12 , Adalberto Ibatici 13 , Monica Crugnola 14 , Costanza Bosi 15 , Roberto Latagliata 16 , Ambra Di Veroli 17 , Luigi Scaffidi 3 , Federico de Marchi 4 , Elisa Cerqui 8 , Barbara Anaclerico 18 , Giovanna De Matteis 19 , Marco Spinsanti 1 , Elena Sabattini 1 , Lucia Catani 1 , Franco Aversa 14 , Francesco Di Raimondo 2 , Umberto Vitolo 5 , Roberto Massimo Lemoli 10 , Renato Fanin 4 , Francesco Merli 11 , Domenico Russo 9 , Antonio Cuneo 12 , Maria Letizia Bacchi Reggiani 20 , Michele Cavo 1 , Nicola Vianelli 1 and Massimo Breccia 16 1 Institute of Hematology “L. and A. Seragnoli”, Sant'Orsola-Malpighi University Hospital, Bologna, Italy 2 Division of Hematology, AOU 'Policlinico-V.Emanuele', Catania, Italy 3 Department of Hematology, University of Verona, Verona, Italy 4 Division of Hematology and BMT, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy 5 Division of Hematology, Citta della Salute e della Scienza Hospital, Torino, Italy 6 Division of Hematology, Azienda Ospedaliera 'Bianchi Melacrino Morelli', Reggio Calabria, Italy 7 Division of Hematology, Ospedale S. Eugenio, Roma, Italy 8 Division of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy 9 Unit of Blood Diseases and Stem Cell Transplantation, ASST Spedali Civili di Brescia, Brescia, Italy 10 Division of Hematology, IRCCS AOU San Martino-IST, Genova, Italy 11 Department of Hematology, A.O. Arcispedale Santa Maria Nuova – IRCCS, Reggio Emilia, Italy 12 Division of Hematology, University of Ferrara, Ferrara, Italy 13 Division of Hematology and Bone Marrow Transplant, IRCCS San Martino-IST, Genova, Italy 14 Division of Hematology, AOU of Parma, Parma, Italy 15 Department of Hematology and Bone Marrow Transplantation, A.O. of Piacenza, Italy 16 Division of Cellular Biotechnologies and Hematology, University Sapienza, Roma, Italy 17 Division of Hematology, Policlinico Tor Vergata, Roma, Italy 18 Division of Hematology, Ospedale S. Giovanni, Roma, Italy 19 Department of Life and Reproduction Sciences, Section of Clinical Biochemistry, University of Verona, Verona, Italy 20 Division of Cardiology, University of Bologna, Bologna, Italy Correspondence to: Francesca Palandri, email: francesca.palandri@unibo.it Keywords: myelofibrosis, splenomegaly, response, ruxolitinib, predictive factors Received: March 29, 2017 Accepted: May 15, 2017 Published: June 27, 2017 ABSTRACT In patients with Myelofibrosis (MF) treated with ruxolitinib (RUX), the response is unpredictable at therapy start. We retrospectively evaluated the impact of clinical/laboratory factors on responses in 408 patients treated with RUX according to prescribing obligations in 18 Italian Hematology Centers. At 6 months, 114 out of 327 (34.9%) evaluable patients achieved a spleen response. By multivariable Cox proportional hazard regression model, pre-treatment factors negatively correlating with spleen response were: high/intermediate-2 IPSS risk ( p =0.024), large splenomegaly ( p =0.017), transfusion dependency ( p =0.022), platelet count 2 years ( p =0.048). Also, patients treated with higher (≥10 mg BID) average RUX doses in the first 12 weeks achieved higher response rates ( p =0.019). After adjustment for IPSS risk, patients in spleen response at 6 months showed only a trend for better survival compared to non-responders. At 6 months, symptoms response was achieved by 85.5% of 344 evaluable patients; only a higher (>20) Total Symptom Score significantly correlated with lower probability of response ( p

Published
2017

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