Brief Introduction–Perinatal mental illness–diagnosis, etiology, treatment options, dilemas, case report presentation Perinatal mental illness is a significant complication of pregnancy and the postpartum period. These disorders include depression, anxiety disorders and postpartum psychosis. Perinatal depression and anxiety are the most common. Their occurrence has complex psychological, environmental and biological underpinnings. Perinatal psychiatric disorders impair a woman's function and are associated with suboptimal development of her offspring. Currently available treatment options have many limitations regarding safety and efficacy. There is a need to establish new treatment tools in this special group of patients. Efficacy of repetitive transcranial magnetic stimulation (rTMS) in decreasing postnatal depression symptoms: a systematic review. Non-pharmacological interventions, such as repetitive Transcranial Magnetic Stimulation (rTMS; a non-invasive brain stimulation technique), are attractive options for women concerned with infant exposure to medication during the breastfeeding period, combining efficacy with low risk. rTMS is an approved treatment for Major Depression Disorder by the Food and Drug Administration (USA), and previous systematic reviews support its efficacy as a stand-alone or add-on procedure to accelerate responsiveness to SSRI's (Wang, 2017), suggesting the scale-up of this intervention to the Postnatal depression disorder (PND). As of now, results concerning its application in postnatal depression come from two open label, one Randomized Controlled Trail (RCT) and one case report. Reliable evidence concerning whether rTMS is indeed effective in treating postnatal depression is lacking. Here, we will present a systematic review that gathers the available information concerning rTMS clinical significance in treating postnatal depression, and establish the direction for needed future studies. Transcranial direct current stimulation for treatment of depression during pregnancy Six pregnant women (mean 32 years) with major depressive disorder (mean HAMD 22.5, mean BDI 26 at baseline) were treated with a two-step tDCS regimen: Two weeks of twice daily tDCS (30 min, 2 mA, anode F3–cathode F4 electrode position) and an optional elongation phase of two weeks with one stimulation per day. Four patients completed the whole study, two patients quitted after two weeks. All patients showed a marked improvement of depression. After two weeks of treatment, patients (n = 6) showed a mean HAMD reduction of 9 points or 37%, including two patients fulfilling response criteria. For BDI ratings, patients showed a mean reduction of 15 points or 54%, 3 achieved response, and one achieved remission. Patients who completed the whole study (n = 4) had a mean HAMD reduction of 17 points or 76%, three achieved response, and one achieved remission. In BDI ratings these patients showed a mean reduction of 17 points or 60%, two achieved response, and one achieved remission. TDCS was well tolerated and there were no adverse effects or serious events related to stimulation. Prevalence and incidence of perinatal depression, anxiety and obsessive-compulsive disorder in Portuguese women Following a categorical and dimensional approach, we will present new epidemiological data on perinatal depression, anxiety and obsessive-compulsive disorders in a population-based cohort of Portuguese women (mean age = 32.75 ± 4.721). The sample sizes range from 300 to 600 subjects depending on the diagnostic/screening instruments used at different stages of this study. Specifically, we will present: – estimates of prevalence of postpartum major depression (n = 475), anxiety disorders (n = 350) and OCD (n = 350) according to the DSM-5 diagnostic criteria, using the Diagnostic Interview for Psychological Distress-Postpartum (DIPD-PP); – proportions of caseness (prevalence and incidence) of clinical significant depressive (n = 600), anxiety (n = 300) and OC symptoms (n = 300) in the second trimester of pregnancy and in the 3rd to 6th months postpartum, according to their scores on the Portuguese versions of the Postpartum/Perinatal Depression Screening Scale, Perinatal Anxiety Screening Scale and Perinatal Obsessive Compulsive Scale. New psychometric and operative parameters of these screening questionnaires will also be presented, as well as relevant correlates and risk-factors of the psychological distress variables measured by these instruments. Perinatal OCD–can rTMS be an answer? A growing body of literature suggests that obsessive-compulsive disorder (OCD) is common in pregnancy and puerperium with risks of persisting consequences for both the mother and her child if untreated. Moreover, OCD is challenging to treat especially in the perinatal period. The extreme responsibility that characterizes OCD patients leads women in the perinatal period, often experiencing obsessions involving the safety of the foetus to a preference of non-pharmacological approaches. However, cognitive-behavioural psychotherapy drop-out rate is high due to time management difficulties especially in exposure and response prevention tasks involving family members or in family environment. One potential treatment alternative to antidepressants for pregnant and postpartum women with OCD is repetitive transcranial magnetic stimulation (rTMS). rTMS has proven to be effective in OCD symptoms and the its non-pharmacologic nature eliminates concerns about foetal exposure to the potential risks of psychotropic medications. However, the absolute number of pregnancies exposed to TMS remains small and evidence regarding its efficacy in women with perinatal OCD is limited. In this presentation we will discuss treatment challenges of perinatal OCD, the potential benefits of a rTMS based approach and present a rTMS protocol designed to treat OCD in the perinatal period.