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2. Cutaneous Neoplasms in Myotonic Dystrophy Type 1

Author

M. Bonfill-Ortí, Joaquim Marcoval, Montserrat Olivé, Ana Talavera-Belmonte, and L. Martínez-Molina

Subjects
Adult, Male, musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Skin Neoplasms, Younger age, Population, Dermatology, Myotonic dystrophy, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Myotonic Dystrophy, Basal cell, In patient, Basal cell carcinoma, education, Aged, Retrospective Studies, education.field_of_study, business.industry, Melanoma, Incidence (epidemiology), Middle Aged, medicine.disease, Surgery, Female, Disease Susceptibility, business, 030217 neurology & neurosurgery
Abstract

Background: The most frequent skin features associated with myotonic dystrophy type 1 (DM1) are frontal alopecia and pilomatrixomas. Several reports suggest that the incidence of basal cell carcinoma is increased in DM1. However, two recently published studies examining this topic have contradictory results. Objective: To retrospectively study the incidence of cutaneous tumours in patients with DM1. Methods: The clinical features of 102 Caucasian patients diagnosed with DM1 at Bellvitge Hospital in Barcelona, Spain, were retrospectively analysed. Clinical charts of the patients were reviewed, and cutaneous tumours diagnosed in our hospital were recorded. A group of 103 Caucasian patients matched for age and sex were used as the control group. Results: A total of 56 male and 46 female patients with DM1 were included in the study (mean age 49.07 years, SD 13.02). At least 1 basal cell carcinoma was diagnosed in 6 patients in the DM1 group versus 3 patients in the control group (p = 0.332). The mean age at diagnosis of the first basal cell carcinoma was 51 years compared with 66 years in the control group (p = 0.035). Five patients with DM1 presented pilomatrixomas versus none in the control group (p = 0.029). We did not detect any melanoma in our DM1 patients. Conclusion: Basal cell carcinomas appeared at a significantly younger age in our DM1 patients than in the general population, and this suggests that, at least in some patients, DM1 may predispose to the development of basal cell carcinomas.

Published
2016

3. Contents Vol. 232, 2016

Author

S D'Adamio, Alexander C.J. van Akkooi, Pascal Jungo, Barbara Meier, Eti Sagy, Pierre Jungo, Marco Galluzzo, Akiva Trattner, Sebahat Genc, Pa-Fan Hsiao, Giuseppe Argenziano, Veronique Bataille, Christina Spehr, Joannes M. M. Groenewoud, George Kontochristopoulos, Satz Mengensatzproduktion, Najoua Haouas, Tirza Klein, Sara Minghetti, Didem Didar Balci, Jorge E. Arrese, Moshe Israeli, Mehmet Ugur Inan, Wolf-Henning Boehncke, Ramya Vangipuram, Montserrat Bonfill-Ortí, Dhekra Chaara, Monica Corazza, Matthias Augustin, Mitra Sepehri, Clio Dessinioti, Jürg Hafner, Luc Thomas, Stella Servoli, Arjen Nikkels, Paul Nathan, Pietro Quaglino, Montserrat Olivé, Markus Streit, Latifa Remadi, Yu-Hung Wu, Yuri Battaglia, Peter Häusermann, Marie-Jeanne P. Gerritsen, Stephan Jeff Rustenbach, Elvira Moscarella, Stefanie von Felten, Emmanuel Laffitte, Lehavit Akerman, Nikhil Yawalkar, Simone Ribero, Jørgen Serup, Iris Zalaudek, Darine Slama, Ali Alikhan, Mark Anliker, Annarosa Virgili, Alexander A. Navarini, Megan E. Melvin, Lone Skov, Muhammet Murat Çelik, Anargyros Kouris, Eve Lebas, Marina Talamonti, Curdin Conrad, Christina Antoniou, Riccardo Pampena, Antonios G.A. Kolios, Vasiliki Efstathiou, Elisa Maietti, Radhia Dabghi, Alessandro Testori, Concetta Potenza, Vasiliki Tzanetakou, Daniel Mimouni, Chrisa Zisimou, Igor Snast, Ebru Celik, Michel Gilliet, Vahid Djamei, Lars E. French, Abigail Fraser, Eftychia Platsidaki, Habib Mezhoud, Alessandro Borghi, Roman Jandarov, Michael David, Adam B. Woldow, Christos Christodoulou, Joaquim Marcoval, Inge Seubring, Luca Borradori, Susana Puig, Henda Jbeniani, Luca Bianchi, Justine Czernielewsk, Panagiota Korkoliakou, Ana Talavera-Belmonte, Julia-Tatjana Maul, Hamouda Babba, Peter Itin, Carlo Mainetti, Caterina Longo, Toral Vaidya, Najla Chargui, Justine Czernielewski, Druckerei Stückle, Laura Martínez-Molina, Peter Jensen, Olivia Odermatt, and Katrina Hutton Carlsen

Subjects
Dermatology
Published
2016

4. Acknowledgement to Referees for Dermatology 2016

Author

George Kontochristopoulos, Satz Mengensatzproduktion, Daniel Mimouni, Alexander A. Navarini, Sara Minghetti, Radhia Dabghi, Mehmet Ugur Inan, S D'Adamio, Yu-Hung Wu, Eve Lebas, Monica Corazza, Najla Chargui, Ali Alikhan, Joannes M. M. Groenewoud, Habib Mezhoud, Eti Sagy, Paul Nathan, Latifa Remadi, Giuseppe Argenziano, Elisa Maietti, Lars E. French, Megan E. Melvin, Dhekra Chaara, Alessandro Borghi, Michael David, Adam B. Woldow, Jürg Hafner, Abigail Fraser, Inge Seubring, Lehavit Akerman, Eftychia Platsidaki, Mark Anliker, Annarosa Virgili, Arjen Nikkels, Anargyros Kouris, Clio Dessinioti, Luca Borradori, Henda Jbeniani, Barbara Meier, Marie-Jeanne P. Gerritsen, Yuri Battaglia, Akiva Trattner, Pa-Fan Hsiao, Najoua Haouas, Elvira Moscarella, Stefanie von Felten, Emmanuel Laffitte, Ana Talavera-Belmonte, Alexander C.J. van Akkooi, Peter Itin, Roman Jandarov, Luca Bianchi, Darine Slama, Caterina Longo, Pascal Jungo, Justine Czernielewski, Toral Vaidya, Druckerei Stückle, Jørgen Serup, Panagiota Korkoliakou, Julia-Tatjana Maul, Christos Christodoulou, Justine Czernielewsk, Laura Martínez-Molina, Matthias Augustin, Marina Talamonti, Carlo Mainetti, Michel Gilliet, Joaquim Marcoval, Mitra Sepehri, Christina Antoniou, Peter Jensen, Riccardo Pampena, Chrisa Zisimou, Pietro Quaglino, Didem Didar Balci, Peter Häusermann, Markus Streit, Moshe Israeli, Ebru Celik, Iris Zalaudek, Lone Skov, Veronique Bataille, Tirza Klein, Olivia Odermatt, Sebahat Genc, Alessandro Testori, Concetta Potenza, Luc Thomas, Antonios G.A. Kolios, Vasiliki Efstathiou, Susana Puig, Katrina Hutton Carlsen, Marco Galluzzo, Ramya Vangipuram, Vasiliki Tzanetakou, Igor Snast, Simone Ribero, Christina Spehr, Vahid Djamei, Montserrat Bonfill-Ortí, Muhammet Murat Çelik, Curdin Conrad, Stephan Jeff Rustenbach, Nikhil Yawalkar, Wolf-Henning Boehncke, Stella Servoli, Montserrat Olivé, Hamouda Babba, Pierre Jungo, and Jorge E. Arrese

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2016

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