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O crescente número de orientadores de internato médico em MGF aumenta a capacidade formativa, o que não é acompanhado pela maior colocação de médicos internos na maioria dos locais. Assim, torna-se necessário estabelecer localmente critérios de seleção que garantam justiça e transparência no processo de atribuição de vagas para a colocação de novos internos. Com o objetivo de debater o tema entre orientadores realizou-se um workshop no Open Day do Orientador da ARSLVT, em maio de 2023. Convidados a selecionar as características que mais valorizavam, a partir de um processo de reflexão conjunta e metodologias participativas, os participantes sugeriram alguns sistemas mais objetivos de seriação de critérios aplicáveis ao orientador, à unidade e à equipa que o acolhe. Concluiu-se ser difícil a elaboração de critérios consensuais, uma vez que a valorização dos mesmos é subjetiva e decorre de experiências pessoais prévias e da realidade local.

Abstract Objective: To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups. Methods: A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102). Results: Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE. Conclusion: It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.

Abstract Introduction: Chronic kidney disease (CKD) is defined as a progressive decline of kidney functions. In childhood, the main triggering factors are congenital anomalies of the kidneys and urinary tract (CAKUT) and glomerulopathies. Inflammatory responses present challenges for diagnosis and staging, which justifies studies on biomarkers/indexes. Aim: To define blood cell count indexes and verify their association with pediatric CKD etiology and staging. The included indexes were: Neutrophil-Lymphocyte Ratio (NLR), Derived Neutrophil-Lymphocyte Ratio (dNLR), Lymphocyte-Monocyte Ratio (LMR), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), and Systemic Immune-Inflammation Index (SII). Methods: We determined the indexes in 52 pediatric CKD patients and 33 healthy controls by mathematical calculation. CKD patients were separated in five groups based on the etiology and staging: Group IA: glomerulopathies at stage 1 or 2; IB: glomerulopathies at stage 3 or 4; IIA: CAKUT at stage 1 or 2; IIB: CAKUT at stage 3 or 4; and III: stages 3 or 4 of other etiologies. In addition, we combined all patients with CKD in one group (IV). Group V was a healthy control group. Results: Lower values of LMR were observed for groups IB and IIB compared to group V (p = 0.047, p = 0.031, respectively). Increased values of SIRI were found for group III versus group V (p = 0.030). There was no difference for other indexes when the groups were compared two by two. Conclusion: The LMR and SIRI indexes showed promising results in the evaluation of inflammation, as they correlated with CKD etiologies and specially staging in these patients.

Abstract The shortage of intensive care unit (ICU) resources, including equipment and supplies for renal replacement therapy (RRT), is a critical problem in several countries. This study aimed to assess hospital mortality and associated factors in patients treated in public hospitals of the Federal District, Brazil, who requested admission to ICU with renal replacement therapy support (ICU-RRT) in court. Retrospective cohort study that included 883 adult patients treated in public hospitals of the Federal District who requested ICU-RRT admission in court from January 2017 to December 2018. ICU-RRT was denied to 407 patients, which increased mortality (OR 3.33, 95% CI 2.39–4.56, p ≪ 0.01), especially in patients with priority level I/II (OR 1.02, 95% CI 1.01–1.04, p ≪ 0.01). Of the requests made in court, 450 were filed by patients with priority levels III/IV, and 44.7% of these were admitted to ICU-RRT. In admitted patients, priority level III priority level I/II was associated with a low mortality (OR 0.47, 95% CI 0.32–0.69, p

The National System of Science, Technology and Innovation (SNCTI) in Brazil comprises an environment formed by public and private institutions, funding agencies, research companies, in addition to a number of instruments instituted in favor of the development of Science, Technology and Innovation activities - ST&I. These constitutive milestones are outlined in the document Estratégia Nacional de Ciência, Tecnologia e Inovação 2016|2022 (ENCTI), where the Government defined guidelines, rules, challenges and goals to promote ST&I in Brazil. The purpose of this article is to discuss the challenge of positioning Brazil among the most developed countries in ST&I, defined in the ENCTI planning for the period 2016-2021. It is also intended to to present and analyze the performance of the two goals defined for this challenge - the first target related to expenditure on research and development - R&D and the second to the human resources active in the R&D. The factors that may have influenced the results complement the study This study used the empirical methodology, with data collection carried out by bibliographic research of secondary sources for data collection and analysis. The data collected covered the period from 2016 to 2019 extracted from the official database. In the analysis, a comparison was made with data from the previous period to verify the evolution of Brazilian performance and the achievement of goals. At the end, the discussion presents the results of the goals and the challenge projected in the ENCTI document, with the performance of indicators from the data collected. DOI: 10.18226/23190639.v10n2.07

No presente artigo objetivamos apresentar o campo curricular em uma leitura pós-estrutural pós-fundacional, sob as lentes da Teoria do Discurso (TD) como proposta por Laclau e Mouffe. Por um caminho de revisão bibliográfica, dentro de uma pesquisa qualitativa, propomos uma apresentação perspectivada tanto da corrente de pensamento quanto da teoria empregada com fins de situar o currículo nessas bases. Neste exercício de revisão, lemos duas influentes obras sobre o Currículo, demonstrando como a perspectiva discursiva amplia as possibilidades de entendimento do elemento curricular em seus diferentes arranjos no tempo. Finalmente, concluímos que o currículo é discurso que significa a realidade e que essa significação está em constante disputa pela hegemonização do significado.

This paper aims to verify the industrial locational pattern changes in the Southeast and Northeast of the country, during the Fernando Henrique Cardoso (FHC) and Luiz Inácio Lula da Silva (Lula), using the locational coefficient Hoover. The operationalization of the index, we used formal employment in the industrial sector in 1995, 2002, 2003 and 2010, corresponding respectively to the initial and final years of FHC and Lula. The results showed losses in the industry during the Cardoso government, as well as leadership in the industrial employment and concentration in the Southeast, in conclusion, the region's importance declined in the following years of his government. During Lula's government, the Northeast region lost employments.

After WWII, magazines turned to fundamental sources for the dissemination of the modern avant-garde project. In this context, the discovery of modern Brazilian architecture through the media by the younger generation of Portuguese architects had enormous consequences for architectural culture. In fact, this modern Brazilian expression became a sign of hope and of future possibilities for the Portuguese architects who used it as a reference to heroically combat the Estado Novo’s regime of censorship. This essay analyses how this information was received and articulated, and how it became an anchor for modern creation in Portugal and its colonies in Angola and Mozambique.

Abstract Objective: To describe a case series of multisystem inflammatory syndrome in children (MIS-C) in a pediatric tertiary hospital. Methods: Patients under the age of 18 years who met MIS-C criteria of the Brazilian Ministry of Health (MH) and/or the Royal College of Paediatrics and Child Health (RCPCH) were included. A retrospective analysis was carried out by reviewing medical records and complementary exams. Results: Six pediatric patients with mean age of 126 months were admitted with fever associated with multisystem involvement: all of them had abdominal pain and diarrhea and two underwent appendectomy; 100% had coagulopathy and increased inflammatory markers; 83% had cardiovascular impairment and 60% required vasoactive drugs; 83% had mucocutaneous symptoms and 50% required ventilatory support by invasive mechanical ventilation or non-invasive ventilation. One patient showed coronary artery dilation on echocardiogram. All patients received empiric antibiotic therapies. SARS-CoV-2 IgG testing was positive in five patients. Treatment was performed after excluding infectious causes: five patients (83%) received intravenous immunoglobulin, five patients (83%) pulse methylprednisolone therapy and one (16%) Tocilizumab. One patient died. The average length of stay in Pediatric Intensive Care Unit (PICU) was seven days. Conclusions: These cases are added to the literature in construction of this emerging condition. Early diagnosis should be considered due to its potential severity.

O presente artigo tem por objetivo verificar as alterações no padrão locacional do setor industrial no Sudeste e Nordeste do País, durante os governos Fernando Henrique Cardoso (FHC) e Luiz Inácio Lula da Silva (Lula), com a utilização do coeficiente locacional de Hoover. Para a operacionalização do índice, foi utilizado o emprego formal no setor industrial nos anos de 1995, 2002, 2003 e 2010, correspondentes respectivamente aos anos iniciais e finais dos governos FHC e Lula. Os resultados alcançados revelam que houve perdas na indústria no Governo FHC, assim como, a hegemonia na concentração do emprego industrial no Sudeste foi reduzida relativamente nos anos seguintes do seu Governo. No governo Lula, a região Nordeste perdeu empregos.

Resenha MATOS, W. S. de; Benedito E. Etnicidades e Infâncias Quilombolas. Curitiba: Editora CRV, 2019. 98 p.

Abstract Objective: to determine the incidence of falls among the elderly population of the city of Barbacena in the state of Minas Gerais, together with causal factors, circumstances and major consequences. Methods: a cross-sectional study was performed through questionnaires applied to 206 patients over the age of 60, from November 2014 to February 2015 in the city of Barbacena, in the state of Minas Gerais. Risk factors related to falls were analyzed, as well as the incidence of falls and the consequences for the lives of elderly persons. The existence of a relationship between the reporting of falls and possible risk factors was determined by the Chi-squared and Fischer's exact tests as indicated. Results: an incidence of falls of 36.41% was observed among the elderly, 45.95% of which occurred outside the home. A total of 85.71% of respondents had previously suffered strokes and 39.78% were taking medication. Among elderly persons who have fallen and suffered fractures (18.67%), 50% had suffered strokes, 50% were suffering from chronic kidney disease, and 61.54% could not perform their activities of daily living after the fall. Conclusion: it was concluded that the incidence of falls among the elderly was 36.41%, while the most correlated factors were drug use, stroke victims and people with chronic kidney disease. Among those who suffered fractures, 61.54% failed to perform activities of daily living. Preventing falls is a public health concern, and simple changes can reduce its prevalence.

O objetivo do trabalho é fazer uma análise das probabilidades de transição nas cidades, das regiões Nordeste (NE) e Sudeste (SE). A ideia é verificar a probabilidade de cidades, com poucas quantidades de empregos, migrarem para cidades com níveis de empregos maiores ao longo do período entre 1991 e 2010, com foco naquelas cidades médias não pertencentes às regiões metropolitanas dos seus respectivos estados. A justificativa do trabalho se dá em virtude de essas regiões serem as que possuem os maiores volumes de empregos absolutos do Brasil. Os dados utilizados foram da classificação dos subsetores da indústria obtidos na Relação Anual de Informação Social (RAIS), fornecida pelo Ministério do Trabalho (MTE). As análises ocorreram com base no procedimento de estimação feita com a utilização das Cadeias de Transição de Markov em tempo discreto. Conclui-se que ao longo do período analisado ocorreu mudança de nível das cidades estudadas com variação para níveis superiores de emprego do setor industrial, demonstrando que não ocorreram perdas do emprego na indústria, ao contrário, o que aconteceu foi um crescimento significativo do emprego formalizado.

This article discusses the issue of taxation of insolvent companies in Portugal, particularly regarding the Portuguese tax on revenue of legal entities (IRC). For this purpose, first, some considerations on the legal framework of insolvent companies are woven and, second, their tax regime is analyzed. Then, a brief review of the main studies that, in the international context, analyze and debate major issues derived from the tax regime of insolvent companies is conducted, particularly in Brazil, Spain, United States, and Italy. Finally, there are the results of an empirical study conducted in Portugal, in 2013, which evaluates and compares the opinions of insolvency administrators (IA), the tax and customs authority (TA), and court magistrates (CM), in order to contribute to a better solution concerning business taxation under this regime. Respondents (IA, TA, CM) demonstrate objective thinking about the fact they believe it is very important that the Portuguese Code of Insolvency and Business Recovery (CIRE) and the Portuguese Code of Tax on Revenue of Legal Entities (CIRC) are modified, now to make clear whether the settlement of property ownership of an insolvent estate is liable to the IRC, then to assign a chapter specifically devoted to the subject of taxation on insolvency in Portugal.

O objetivo da pesquisa é descrever o comportamento dos diferenciais de empregos formalizados entre as cidades médias não metropolitanas das regiões do Brasil. Deve-se levar em consideração que esse trabalho limitou-se a estudar tão somente o setor industrial nas cidades em pauta. A metodologia utilizada uma pesquisa bibliográfica aliada ao Índice de Quociente de Localização, o qual tem por finalidade identificar a especialização produtiva das cidades em cada região, refletindo o deslocamento do capital, quando comparadas com a mesma atividade para o Brasil. Os resultados mostraram que a Região Sudeste, continua sendo a detentora do maior quantitativo de empregos formais entre as regiões, como as cidades com maior quantidade de especialização nas atividades mais intensivas em capital. O capital reorganiza o investimento nos espaços que lhe garantem a lucratividade, relocalizando-o de forma a manter os lucros elevados a custa de baixos salários e apropriação de externalidades positivas criadas pelo estado.

OBJECTIVES: We assessed whether maternal employment during pregnancy – overall and in selected occupational sectors – is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. METHODS: We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. RESULTS: Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (OR_adj) 0.86, 95% confidence interval (95% CI) 0.81–0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (OR_adj 0.91, 95% CI 0.84–0.99) whereas food industry workers had an increased risk of preterm delivery (OR_adj 1.50, 95% CI 1.12–2.02). There was little evidence for heterogeneity between cohorts. CONCLUSIONS: This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.

This research aimed to assess the work published in the journal Kairos Gerontology, from 1998 to 2014, with the theme: elderly affected by cerebrovascular accident. It was intended to be a reflection of the importance of this thematic gerontogeriatria, contributing to the social integration of older persons, from a holistic look. At the end of this survey, we can affirm the importance of respect to reality of these elderly people in its context of life, as well as preventive measures in primary areas, with awareness of the population for the control of various vascular risk factors such as blood pressure, diabetes, cholesterol, triglycerides, heart disease, in addition to the need to refrain from smoking, having a healthy diet and physical exercise.

A pesquisa visa identificar a localização do emprego industrial nas cidades médias não metropolitanas das regiões Nordeste e Sudeste do Brasil, as quais tenham população entre 100 e 500 mil habitantes, no período de 1990 a 2013. A base de dados consta na Relação Anual de Informações Sociais (RAIS), do Ministério do Trabalho e Emprego (MTE), importante para a aplicação do Quociente de Localização (QL) nos 15 segmentos do setor industrial. O uso desse indicador (QL) mostra o grau de concentração relativa do segmento em cada uma das cidades em pauta. Além disso, a Matriz de Transição da Cadeia de Markov analisa as probabilidades de mudanças de estados nas variáveis analisadas. Os resultados mostraram aumentos nas quantidades de empregos nas cidades em pauta.

A doença periodontal resulta da resposta inflamatória do hospedeiro ao acúmulo de placa bacteriana, que desencadeia a formação de cálculo dentário e gengivite. O objetivo desse estudo foi determinar a incidência de cálculo dentário (CD) e doença periodontal (DP) por grupo dentário, arcada dentária e faixa etária dos animais, utilizando as tabelas de escores específicas para CD e DP. Vinte e cinco cães da raça Beagle foram anestesiados e submetidos ao exame clínico da cavidade oral, para mensuração do grau de CD e DP. Verificou-se aumento diretamente proporcional entre os escores do CD e da DP e a idade dos animais. Os grupos dentários maxilares foram mais acometidos pelo CD e DP, quando comparados aos mandibulares. Os dentes incisivos e caninos se destacaram, respectivamente, como os grupos dentários de menor e maior comprometimento pelo CD e DP

Passados praticamente quatro anos desde a eleição de Luiz Inácio Lula da Silva à presidência da República, e da famosa Carta ao Povo Brasileiro[1], a qual explicitou categoricamente sua submissão às regras, demandas e necessidades do Capital, muitos segmentos sociais e políticos ainda se encontram, de certa forma, paralisados diante das políticas econômica, social e educacional emanadas de Brasília.

Foram realizadas análises citogenéticas em espécimens de Astyanax scabripinnis provenientes de duas populações da região do triângulo mineiro (Campina Verde - MG). As duas populações apresentaram número diplóide igual a 50 cromossomos. A impregnação pela Prata evidenciou um sistema de NORs múltiplas. Os blocos de heterocromatina constitutiva foram localizados na região telomérica de alguns cromossomos subtelocêntricos/acrocêntricos, no braço menor de um submetacêntrico, além de uma banda intersticial em um cromossomo acrocêntrico (população do córrego Cruz da Retirada Bonita).

Chronic kidney disease (CKD) can be defined as the progressive loss of renal function, characterized by a decreased glomerular filtration rate (GFR). The etiology of CKD in childhood is mainly associated with congenital anomalies of the kidneys and urinary tract (CAKUT) and with glomerular diseases. The goal of this study was to investigate the hemostasis and oxidative stress in pediatric CKD of different etiologies. Fifty-four CKD children and adolescents and 52 controls were enrolled in this study. The evaluation of hemostasis was carried out by determination of D-dimer (D-Di) and plasminogen activator inhibitor (PAI-1) plasma levels, while oxidative stress was evaluated by thiobarbituric acid reactive substance (TBARS) levels, protein carbonyl content, plasma antioxidant capacity (MTT), and ascorbate. The D-Di was increased in CAKUT stage 3 or 4 patients compared with those with glomerular disease. PAI-1 was increased in patients with glomerular disease compared with CAKUT. Carbonyl protein content was higher in the control group compared with glomerular disease stage 3 or 4 patients. Our findings showed that the reduction in GFR is associated with a state of hypercoagulability. The analysis of integrated networks showed an expansion of connections among hemostatic and oxidative stress markers in CKD children and adolescents compared with controls. Key words: chronic kidney disease, hemostasis, oxidative stress, children, adolescents L'insuffisance renale chronique (IRC) correspond a une deterioration progressive du fonctionnement des reins caracterisee par une diminution du taux de filtration glomerulaire (TFG). L'etiologie de l'IRC chez l'enfant est principalement associee aux anomalies congenitales des reins et de l'arbre urinaire (ACRAU), ainsi qu'a des maladies glomerulaires. Cette etude portait sur l'hemostase et le stress oxydatif dans l'IRC pediatrique d'etiologies diverses. Nous avons inscrit a cette etude 54 enfants et adolescents atteints d'IRC, avec 52 sujets temoins. Nous avons procede a l'evaluation de l'hemostase en etablissant les taux plasmatiques de d-dimeres (D-Di) et de l'inhibiteur de l'activateur du plasminogene (PAI-1), et celle du stress oxydatif avec les taux de derives reactifs de l'acide thiobarbiturique (TBARS), le taux de proteine carbonyl, la capacite antioxydante plasmatique (MTT) et l'acide ascorbique. Nous avons observe une hausse plus marquee des D-Di chez les patients presentant une ACRAU au stade 3 ou 4 qu'en cas de maladie glomerulaire. La hausse du PAI-1 etait plus importante avec la maladie glomerulaire que chez les patients atteints d'ACRAU. Le taux de proteine carbonyl etait plus eleve chez les temoins que chez les patients atteints d'une maladie glomerulaire au stade 3 ou 4. Nos resultats ont montre que la diminution du TFG est associee a un etat d'hypercoagulabilite. L'etude de reseaux integres a montre une expansion des connexions parmi les marqueurs de l'hemostase et du stress oxydatif plus importante chez les enfants et les adolescents atteints d'IRC que chez les temoins. [Traduit par la Redaction] Mots-cles : insuffisance renale chronique; hemostase, stress oxydatif; enfants; adolescents., Introduction Chronic kidney disease (CKD) can be defined as the progressive loss of renal function, characterized by a glomerular filtration rate (GFR) of less than 90 mL/min/1.73 [m.sup.2] for more [...]