1. Maternal and fetal outcome of pregnancy in Swiss mice infected with Plasmodium berghei ANKAGFP
- Author
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Caroline Gomes, Noruê Salum, Juliane Centeno Muller, Ana Claudia Boareto, R.R. Carvalho, Claudio Romero Farias Marinho, Jonas Golart da Silva, Paulo Roberto Dalsenter, José Ederaldo Queiroz Telles, Rafaela Maristany Sargaço, Fernanda Vergara, and Francisco José Roma Paumgartten
- Subjects
medicine.medical_specialty ,Plasmodium berghei ,Offspring ,Physiology ,Intrauterine growth restriction ,Gestational Age ,010501 environmental sciences ,Toxicology ,01 natural sciences ,Fetal Development ,Antimalarials ,03 medical and health sciences ,Pregnancy ,parasitic diseases ,medicine ,Animals ,030304 developmental biology ,0105 earth and related environmental sciences ,0303 health sciences ,Fetus ,Fetal Growth Retardation ,biology ,business.industry ,Pregnancy Outcome ,Fetal Body Weight ,medicine.disease ,biology.organism_classification ,Malaria ,Disease Models, Animal ,Animals, Newborn ,Pregnancy Complications, Parasitic ,Female ,Histopathology ,business - Abstract
Malaria in pregnant women is associated with risk of maternal and perinatal morbidity and mortality, and there are few antimalarial drugs considered safe to treat them, so it is necessary to develop safer antimalarial medicines. The goal of this study was to develop an animal model for human malaria during pregnancy by characterizing the maternal and fetal outcomes in malaria infected Swiss mice. For that, in the present study, we evaluated the outcome of pregnancy in Swiss mice infected with Plasmodium berghei ANKAGFP. We observed a reduction of fetal body weight and signs of skeletal ossification retardation in the offspring of mice infected on GD 12. The group of mice infected with malaria presented premature deliveries and histopathology changes consistent with placental malaria. Our study suggests that Swiss Webster mice infected with P. berghei ANKAGFP on GD 12 might be a valuable model to investigate the safety and the efficacy of new antimalarial drugs indicated to pregnant women.
- Published
- 2019
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