1. Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
- Author
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Adriano Caixeta, Maria Cristina de Oliveira Izar, Ieda Maria Longo-Maugéri, Ana Carolina Carneiro Aguirre Casarotti, Iran Gonçalves, Francisco Antonio Helfenstein Fonseca, Gilberto Szarf, Henrique Tria Bianco, Daniela Teixeira, Ibraim Pinto, Flavio T. Moreira, Mayari Eika Ishimura, Maria E. R. Coste, and Amanda F Bacchin
- Subjects
Adult ,Male ,0301 basic medicine ,Immunology & Inflammation ,medicine.medical_specialty ,Myocardial Infarction ,Biophysics ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Troponin T ,Antigens, CD ,Cardiac magnetic resonance imaging ,Internal medicine ,cardiac MRI ,medicine ,Humans ,ST segment ,cardiovascular diseases ,Myocardial infarction ,Prospective cohort study ,Molecular Biology ,Research Articles ,B-Lymphocytes ,Ejection fraction ,medicine.diagnostic_test ,biology ,business.industry ,Cell Biology ,medicine.disease ,Magnetic Resonance Imaging ,cytokines ,Interleukin-10 ,B-1 cell ,030104 developmental biology ,Integrin alpha M ,Cardiovascular System & Vascular Biology ,B Lymphocytes ,cardiovascular system ,Cardiology ,biology.protein ,Translational Science ,Female ,Interleukin-4 ,business - Abstract
Despite early reperfusion, patients with ST segment elevation myocardial infarction (STEMI) may present large myocardial necrosis and significant impairment of ventricular function. The present study aimed to evaluate the role of subtypes of B lymphocytes and related cytokines in the infarcted mass and left ventricular ejection fraction obtained by cardiac magnetic resonance imaging performed after 30 days of STEMI. This prospective study included 120 subjects with STEMI submitted to pharmacoinvasive strategy. Blood samples were collected in subjects in the first (D1) and 30th (D30) days post STEMI. The amount of CD11b+ B1 lymphocytes (cells/ml) at D1 were related to the infarcted mass (rho = 0.43; P=0.033), measured by cardiac MRI at D30. These B1 cells were associated with CD4+ T lymphocytes at D1 and D30, while B2 classic lymphocytes at day 30 were related to left ventricular ejection fraction (LVEF). Higher titers of circulating IL-4 and IL-10 were observed at D30 versus D1 (P=0.013 and P
- Published
- 2021
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