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Abstract In lung disease, persistence of KRT8-expressing aberrant basaloid cells in the alveolar epithelium is associated with impaired tissue regeneration and pathological tissue remodeling. We analyzed single cell RNA sequencing datasets of human interstitial lung disease and found the profibrotic Interleukin-11 (IL11) cytokine to be highly and specifically expressed in aberrant KRT8+ basaloid cells. IL11 is similarly expressed by KRT8+ alveolar epithelial cells lining fibrotic lesions in a mouse model of interstitial lung disease. Stimulation of alveolar epithelial cells with IL11 causes epithelial-to-mesenchymal transition and promotes a KRT8-high state, which stalls the beneficial differentiation of alveolar type 2 (AT2)-to-AT1 cells. Inhibition of IL11-signaling in AT2 cells in vivo prevents the accumulation of KRT8+ cells, enhances AT1 cell differentiation and blocks fibrogenesis, which is replicated by anti-IL11 therapy. These data show that IL11 inhibits reparative AT2-to-AT1 differentiation in the damaged lung to limit endogenous alveolar regeneration, resulting in fibrotic lung disease.

Objectives: This study aims to determine the effect of a toll-like receptor 7/8 (TLR7/8) ligand on the motility of putative X- and Y-chromosome-bearing sperm in rams. Materials and Methods: Sperm from three fertile rams were incubated with tris-citrate buffer containing 0 to 0.9 μM resiquimod (a TLR7/8 ligand) that affects only the X chromosome sperm. Sperm was then subjected to a swim-up test method. After incubation, sperm in the top and lower layers of the media were transferred into a separate new tube. Sperm motility characteristics, concentration, morphometry, and adenosine triphosphate (ATP) concentration from both layers were identified. The data were analyzed for multiple comparisons using one-way analysis of variance. Results: The study demonstrated that the presence of resiquimod used in the swim-up method facilitated the morphometric separation of smaller sperm, predominantly representing Y chromosome sperm in the top layer. Meanwhile, larger samples, indicating X chromosome sperm, accumulated in the lower layer of the media, thus increasing sperm concentration. Resiquimod also decreased motility in the lower layer, but samples in the top layer were unaffected. This decrease was reinforced by the depletion of the ATP level of sperm at the lower level. Conclusion: The TLR7/8 ligand reduced the motility of the putative X-sperm by decreasing their ATP content, allowing separation from the putative Y-sperm. These results suggested the importance of TLR7/8 as a potential biomarker in sperm selection technology. [J Adv Vet Anim Res 2024; 11(3.000): 648-654]

Abstract Background Mercury chloride (HgCl2) damages tissues it comes in contact with in sufficient concentration. This study evaluated the protective effects of n-butanol fraction of Phoenix dactylifera (BFPD) on mercury-triggered liver toxicity in Wistar rats. 25 male rats were divided into 5 groups of 5 rats each. Group I was administered 2 ml/kg of distilled water; group II was administered 5 mg/kg of HgCl2; group III was administered 500 mg/kg of BFPD + 5 mg/kg of HgCl2; group IV was administered 1000 mg/kg of BFPD + 5 mg/kg of HgCl2, while group V was administered 100 mg/kg of silymarin + 5 mg/kg of HgCl2. orally for 2 weeks. The rats were euthanized and liver tissue blood samples were collected for histological, histochemical, stereological, immunohistochemical, molecular, and biochemical studies. Results The results revealed that HgCl2 induced oxidative stress in the rats evident by histoarchitectural distortions and altered levels of liver enzymes, proteins, and oxidative stress biomarkers when compared to the control. However, BFPD treatment restored these changes. Glutathione peroxidase levels decreased (p

This research aims to examine the role played by Ma'arif Nahdlatul Ulama (NU) Educational Institutions in depicting the dynamics of Islamic education development in Indonesia. The focus of this research is to analyze the contribution of these educational institutions to the evolution of the Islamic education system, both in terms of curriculum, teaching methods, and their impact on student character formation. The research method includes historical analysis discussing the history and development of Ma'arif NU Educational Institutions since their establishment. The main data sources involve historical documents, archives, and interviews with key actors in these educational institutions, such as teachers, students, and administrators. The results of this research are expected to provide a comprehensive overview of how the role of Ma'arif NU Educational Institutions has shaped and influenced the context of Islamic education in Indonesia. Additionally, this research will also discuss the challenges and opportunities faced by these educational institutions in responding to the changing times and evolving educational demands.

This research aims to examine the efforts of GUPPI in reforming Islamic education in Indonesia. This study employs a literature review methodology, utilizing a qualitative approach with a historical method. Data is collected through literature from various journals and relevant websites concerning the research subject. The findings reveal that GUPPI experienced fluctuations, both during the New Order era and the Reform era. During the New Order era, GUPPI saw institutional development in assets and territory, indicating significant progress due to its political ties with Golkar. However, GUPPI's idealism to further develop Islamic education stagnated during the Reform era. In the VII GUPPI Congress in 1998, GUPPI disaffiliated from the Golkar party and returned to being an independent organization. Post-VII and VIII Congresses from 2005 to 2011, GUPPI continued to grapple with internal issues and sought strategies for revival.

Islamic education in Indonesia has experienced rapid development alongside the growth of the Muslim population. This paper discusses the role of Integrated Islamic Schools (IIS) as a new trend in Islamic education in Indonesia. This article analyzes the historical development of Islamic education, the role of IIS in facing the challenges of modernization, and its impact on Indonesian Muslim society. In the context of the development of Islamic education, there has been significant transformation during the reform era, including changes in the national education system. Islamic education is no longer confined to traditional models, and the emergence of IIS in several major cities marks a step towards the modernization of Islamic educationThis article employs a qualitative descriptive research method focusing on data analysis from various sources, including books, journals, and relevant publications. The research findings indicate that IIS, as part of the Integrated Islamic Schools Network of Indonesia, has attracted public attention, especially in major cities. Despite the high cost of education, IIS is considered an alternative Islamic education that combines Islamic values with a modern approach.

This research aims to analyze the issues surrounding the development of Islamic Higher Education through the application of literature review methodology. Literature review methodology involves collecting and analyzing relevant literature and references to understand the associated issues within the context of Islamic higher education institutions. The study adopts a qualitative approach by analyzing various literatures, journals, books, and related theoretical sources. The data obtained are descriptively analyzed to identify patterns and trends in the dynamics of Islamic higher education institutions. The findings reveal that these institutions face complex dynamics in addressing contemporary challenges. Furthermore, this abstract identifies challenges encountered by Islamic Higher Education institutions, such as competition with non-Islamic educational institutions, enhancing the quality of human resources, funding, and accreditation issues. These challenges require innovation and appropriate strategies to ensure the sustainability and success of Islamic Higher Education institutions. In conclusion, this abstract highlight the dynamics occurring within Islamic Higher Education institutions.

This research examines the changes and continuity of the Islamic Community Association in education from 1969 to 2000. This study employs a qualitative descriptive library research method using a historical approach. The research findings indicate that since 1911, the Ulama Association has pioneered modern educational patterns by integrating religious education, general education, and life skills learning (entrepreneurship). This educational institution encompasses 282 Non-Formal Islamic Schools (Madrasah Diniyah), 308 Kindergartens and Islamic Education Centers (TK, RA, TPA), 165 Elementary Schools (Madrasah Ibtidaiyah), 93 Junior High Schools (Madrasah Tsanawiyah), 47 Senior High Schools (Madrasah Aliyah), 7 Universities, 83 Islamic Boarding Schools (Pondok Pesantren), and 1200 Study Groups (Majlis Ta’lim) spread across Java, particularly in West Java, and partly in South Sumatra.

This research aims to explain the dynamics of Mathla’ul Anwar educational institution from a management perspective. This research type is qualitative with a Library Research approach. The research data is in the form of data about The dynamics of Mathla’ul Anwareducational institution from its management aspect from primary sources in the form of books on the dynamics of educational institutions, Mathla'ul Anwar educational institutions, book development institutions in Islamic education and relevant journals. Data collection techniques were carried out using documentation studies. The researchers' data sources were obtained from books and journals about the dynamics of Mathla’ul Anwar educational institution from a management perspective. Data analysis uses Content Analysis. Based on the research results obtained, the dynamics of Mathla’ul Anwar educational institution in terms of management shows that this institution has succeeded in integrating various important elements in education to achieve its main goals. With a strong historical background and commitment to Islamic values, Mathla'ul Anwar continues to innovate and adapt to changing times. Management aspects, which include planning strategies, organizational structure, curriculum development, monitoring, and evaluation, as well as the development of human resources and facilities, have been implemented well. Overall, effective and efficient management at Mathla'ul Anwar has produced an educational institution that not only focuses on academic achievement but also builds the character and morals of students. This institution is able to face challenges and make good use of opportunities, continuing to be committed to producing a generation of knowledge, faith, and piety. Through good management, it is hoped that Mathla'ul Anwar can continue to make a meaningful contribution to the progress of education in Indonesia. Thus, this conclusion shows that the Mathla'ul Anwar educational institution continues to innovate and adapt to changing times and can make a positive contribution to creating a better educational institution.

This research aims to explain the dynamics of Mathla'ul Anwar educational institution from an educational aspect. This research type is qualitative with a Library Research approach. The research data consists of data about the dynamics of Mathla'ul Anwar educational institution from the educational aspect from primary sources in the form of books on the dynamics of educational institutions, Mathla'ul Anwar educational institutions, books on institutional development in Islamic education, and relevant journals. Data collection techniques were carried out using documentation studies. The researchers' data sources were obtained from books and journals about the dynamics of Mathla'ul Anwar educational institutions from the educational aspect. Data analysis uses Content Analysis. Based on the research results obtained, Mathla'ul Anwar is an educational institution that emphasizes a holistic approach to developing its students. They integrate educational academies with the formation of moral character and spirituality based on Islamic values. Their curriculum includes general subjects such as mathematics and science, as well as in-depth Islamic religious studies and Arabic. In addition, this institution is active in developing students through various extracurricular activities such as sports, arts, and community service, which aim to develop special skills and social values. Mathla'ul Anwar also pays attention to developing teacher professionalism through continuous training and professional education, ensuring that the teaching delivered remains relevant and in accordance with high educational standards. With their commitment to holistic education and Islamic values, this institution prepares students to become comprehensive individuals of high integrity, ready to face global challenges and contribute positively to society.

This research aims to understand the changes within Muhammadiyah's Islamic educational institutions, including the influencing factors and the programs developed to enhance the quality and effectiveness of the education provided. This research identifies factors influencing the development of these educational institutions, including political policies, socio-cultural changes, technological advancements, and Muhammadiyah's educational thoughts and movements. The findings reveal four dynamic periods of educational development within the Muhammadiyah organization: the pioneer period (1900-1923), the development period (1923-1970), the institutionalization period (1970-1998), and the transformation period (1998-present). In the 1970s, the development of Islamic education within Muhammadiyah began with religious-plus schools, which later formed the basis for establishing Muhammadiyah boarding schools.

This study aims to elucidate Persis's pivotal role in fostering the growth of Islamic boarding school institutions in Indonesia between 1923 and 1962. Employing a descriptive qualitative approach, this research utilizes library research methods and content analysis. Primary sources include the Sipatahoenan Newspaper and Bendera Islam. The findings reveal that Persis's emphasis on primary and secondary education has culminated in the establishment of 230 Islamic Unity Islamic Boarding Schools nationwide. Moreover, Persis has notably founded the Islamic Education University as a tertiary-level institution. The organization also facilitates courses and discussion forums addressing religious matters and disseminates literature to advance the discourse on Islamic propagation and education renewal. Regarding the educational curriculum, Persis integrates Islamic studies, Quranic teachings, and Hadith studies with conventional education. However, challenges persist in the operational aspects of Islamic educational institutions, necessitating enhancements in management practices, augmenting educational facilities, and bolstering the quality of human resources.

This study aims to determine the background of the establishment of the Al-Irsyad Al-Islamiyyah Educational Institution and the education system at the Al-Irsyad Al-Islamiyyah Educational Institution. The type of research used in this study is library research. The point is to answer the problem formulation, the author collects data from books, journals, scientific papers, and so on. The study also used an induction and deduction approach where the collected data was drawn to generalizations to conclusions. The results of this research are the background for the establishment of the Al-Irsyad Al-Islamiyyah Educational Institute. The organization was founded in 1914 by Sheikh Ahmad Surkati Al-Anshori, a great cleric from Mecca who came from Sudan. Al-Irshad Al-Islamiyyah focuses on education, teaching, social, and da'wah at the national level. Al-Irshad Al-Islamiyyah is committed to purifying the teachings of Islam, expanding science, and developing a civilized and Islamic moral society. Al-Irshad Al-Islamiyyah aims to purify tawhid, worship and amaliyah Islam. Engaged in education and da'wah. To realize this goal, AI Irsyad has established hundreds of formal schools and non-formal educational institutions throughout Indonesia. And in its later development, Al-Irshad activities also penetrated the health sector, by establishing several hospitals. The largest are currently Al-Irsyad Hospital in Surabaya and RS. Siti Khadijah in Pekalongan.

Al-Jam'iyatul Al Washliyah is an Islamic educational institution in Indonesia founded in 1930 in Medan, North Sumatra by Haji Mohd Arsyad Al Banjari, it aimed to disseminate Islamic teachings and strengthen the identity of Muslims in Indonesia. This research employs a literature study method relying on bibliographic sources from recent journal articles and books related to the core issues and data interpretation through expert insights with a constructive approach and content analysis interpretation. The scope of the study encompasses the period from the establishment of Al Washliyah in 1930 until the end of the 20th century, specifically the year 2000. Al Washliyah was established during the Dutch colonial period to unite Muslims and advocate for Indonesian independence. They demonstrated a high commitment to education by establishing schools and madrasas and forming the Education, Teaching, and Cultural Council. During the 14th Al Washliyah Congress, they formulated educational development plans focusing on household education, madrasa/higher education, and community education. The Al Washliyah management was dedicated to education, having its curriculum for madrasas.

This research aims to examine how the dynamics of Ma'arif Nahdlatul Ulama Education Institute contribute and make a major contribution to the progress of the Indonesian nation. The research was written based on a literature review, in-depth understanding, and accumulated understanding from various trusted primary book sources. This research type is qualitative with a Library Research approach. Data collection techniques are carried out using documentation. Data sources come from books and journals. The data analysis technique uses Content Analysis. The study results show that in developing education, NU has many Islamic boarding schools and madrasas spread across the country and also has public schools from kindergartens to universities. NU formed Rabithah Ma'ahid al-Islamiyah (RMI) to implement NU policies in the field of developing Islamic boarding schools and formed the Education and Ma'arif Institute to implement NU policies in the education field and teaching, both formal and non-formal, apart from Islamic boarding schools. The forms of education institutes at NU include Islamic boarding schools, madrasas, schools, and colleges. It is in this context that NU is making every effort to improve and develop its education while encouraging religious values, especially in the field of Ahlu al-Sunnah wa al-Jama'ah, teaching optimally to obtain optimal results by improving the quality of teaching staff through training so that they can master various learning strategies, be empowered and able to be creative in making/using literacy learning media by implementing technology in learning.

This study aims to examine the dynamics of Al-Azhar Hamka Islamic educational institution, past, present and future. This research was written based on literature review and in depth understanding and accumulated understanding from various trusted primary book sources. This research type is qualitative with a library research approach. Data collection techniques are carried out with documentation. Sources of data come from books and journals. Data analysis technique using Content Analysis. The study results show that Hamka's Thought in Al-Azhar is actually very centered on instilling values, ethics and also respect for nationalism as an important part of education. Without these three elements, Hamka sees that education is not yet a complete system. These three things are then elaborated in the spirit of Islam as well as Islamic values and the cultural heritage of science, language and literature from Islamic civilization. Educational management from Al Azhar and Hamka must eventually learn to apply the values needed for modern education. The system used is no longer a top down system but an engagement study and continued with the implementation of activities that are appropriate for existing students.

This research aims to describe the educational dynamics of the West Java Ulama Association organization. The research method used is qualitative research. Data came from literature searches or studies on educational dynamics in West Java ulama union organizations. The data used is primary data. Data sources were obtained from books and journals of the West Java Ulama Association—data analysis using content analysis. The study results stated that the Ulama Association was a manifestation of the renewal movement in the Majalengka area, West Java. Ulama Association is a renewal movement founded by KH. Abdul Halim in 1887 in Cibelerang, Majalengka, West Java. KH. Abdul Halim founded Hayatul Qulub, which is engaged in education and economics. Finally, after four years of activity, 1915, the government closed the Hayatul Qulub organization due to fights with traders from China, in 1916 KH. Abdul Halim founded Majlisul 'Ilmi, which is well connected with Jam'iat Khair and Al-Irsyad in Jakarta. Then, in 1917, assisted by H.O.S. Cokroaminoto, it became the Ulama Association. The Ulama Association Education System has two stages. First, the alaqah system or traditional education system, the halaqah system is also called the weapon system, namely where the students take lessons by sitting around kiai in the room, and kiai explains the material in lectures. Second, the modern education system is an education model that uses classes using chairs and tables that are guided and organized in the form of class levels and over some time. The influence of the establishment of the Ulama Association on the Education System increased knowledge such as religious, social, arithmetic, and linguistics, as well as skills teaching. Based on this description, in development, the organization of the Ulama Union experienced various changes from time to time.

This study aims to examine the dynamics of Islamic College from an education aspect that is developing in Indonesia. This work was written based on literary studies, in-depth understanding, and accumulated understanding from various trusted primary book sources. This type of research is qualitative with a library research approach. Data collection techniques are carried out by collecting data. Sources of data come from books and journals. Data analysis technique using Content Analysis. This research results show that science development and technology in the globalization era impact all dimensions of people's lives. This condition continues to roll in the dynamics of community life. Even PTKIN feels these developments impact. Therefore, PTKIN continues to make institutional and curriculum-updating efforts. Management of the College must be transparent and accountable so that all parties can access various information universities are developing. This needs to be considered by the manager of the university. This is because the campus has an academic climate; of course, the entire academic community must think positively and honestly and understand. Likewise, with leadership in College, a leader must open a space that can be navigated and is not discriminatory to all campus residents.

This study aims to determine the dynamics of Darud Dakwah Wal Ersyad Education Institute. This study uses quantitative research. The data used in this research is secondary data. Data obtained were obtained from literature studies or literature studies from articles and books. Data analysis was performed using content analysis. Based on the results presentation of the literature study, the dynamics of DDI educational institutions can be summarized as follows: 1) There are 800 Madrasas in Indonesia. Education is general, consisting of DDI Islamic Kindergarten (TKI) to DDI Islamic Senior High School (SMAI). Education is Fanniyah in nature which consists of: DDI Islamic Community Schools (SKI), DDI Islamic Trade Courses (KDI), DDI Islamic Teacher Schools (SGI), DDI Islamic Kindergarten Teacher Schools (SGTKI), DDI Islamic Boarding Schools (SKTI); 2) 50 DDI Islamic Boarding Schools throughout Indonesia, 36 in South Sulawesi each, 3 in Central Sulawesi, 3 in Southeast Sulawesi, 2 in Gorontalo, 2 in East Kalimantan, 1 in South Kalimantan, 1 in Riau, one fruit in East Java, one fruit in Timika, one fruit in Jayapura, and one fruit in Biak; 3) For tertiary institutions, fourteen DDI assisted units, 1 STAI in Barru, 1 STAI in Pare-Pare, 1 STAI and STKIP in Pinrang, 3 STAI in Polmas (1 STAI, 1 STKIP, 1 STIP), 1 STAI in Sidrap, 1 STAI in Maros, 1 STAI in East Kalimantan, 1 STAI in Makassar, 1 STAI in Jeneponto, 1 STAI in Majene, 1 STAI in Pangkep, and 1 STAI and STKIP in Mamuju. Madrasas abroad, especially in Malaysia, have yet to submit their reports to PB-DDI, so data collection cannot be carried out. Based on the results above, it can be concluded that DDI is developing in education.

This study aims to explain the dynamics of the management of Muhammadiyah Education Institutions. This research type is qualitative with a library research approach. The research data is in data form on the Dynamics of Muhammadiyah Education Institutions in management aspects from primary sources in the form of relevant books and journals. Data collection techniques are carried out with documentation. Research data sources were obtained from books and journals on the Dynamics of Muhammadiyah Educational Institutions in management. In data analysis using Content Analysis. Based on the descriptions, it is concluded that since its establishment, Muhammadiyah educational institutions have continued to develop and increase both in quantity and quality. However, some institutions have experienced setbacks and even closed. This is the dynamics of educational institutions that must be accepted. So far, the management used by Muhammadiyah has made the founders of Muhammadiyah schools eager to compete. However, according to the author, the current management needs to be thoroughly evaluated to improve the quality of Muhammadiyah's education.

The purpose of this study was to find out the history and dynamics of Persis educational institutions. The research method uses library research with data sources in books form and scientific journals related to the dynamics of educational institutions. Data analysis techniques use content analysis. The study results revealed that Persis birth began with a tadarusan formation (Islamic religious study) group in Bandung city led by H. Zamzam and H. Muhammad Yunus. Persis has been led by several figures who have their characteristics of thought, including KH. Zamzam as Persis founder. Ahmad Hasan is the main teacher and founder of Persis. Mohammad Natsir is a political scholar. KH. E. Abdurrahman was a great scholar and a humble legal expert. Persis gives great attention to the education field. In this education field, Persis has established educational institutions ranging from early childhood or kindergarten to tertiary institutions, both in madrasas form, schools, and Islamic boarding schools. Apart from that, Persis also organizes courses and discussion groups. So it is necessary to maintain this spirit, especially in eradicating stupidity context, backwardness, superstition, heresy, and Indonesian colonization by carrying out enlightenment among Muslims.

This study aims to examine the struggle of Nahdlatul Wathan to participate in and make a major contribution to the Indonesian nation's progress. The research is written based on literary studies, in-depth understanding, and accumulated understanding from various trusted primary book sources. This type of research is qualitative with a library research approach. Data collection techniques are carried out by data collection. Sources of data come from books and journals. Data analysis technique using Content Analysis. Results of this study show that Nahdlatul Wathan Diniyah Islamiyah Islamic education's existence in terms of education meaning had undergone evolution/development as a continuum of meaning when history first occurred, present, and future. The historical phenomenon shows that apart from establishing a men's Islamic education (Nahdlatul Wathan), figures (founders) also founded a women's Islamic education (Nahdlatul Banat). Nahdlatul Wathan is a social organization engaged in education, social and Islamic da'wah and adheres to Islam Ahlusunnah wal Jama'ah. The Imam Syafi'I school continues and continues to exist in this Pancasila. This shows that Nahdlatul Wathan, an Islamic organization, has always fought for Ahlusunnah wal Jama'ah to uphold the creed so that Muslims can accept it in this country.

Objective To assess whether the risk of cardiovascular complications of covid-19 differ between the sexes and to determine whether any sex differences in risk are reduced in individuals with pre-existing cardiovascular disease.Design Registry based observational study.Setting 74 hospitals across 13 countries (eight European) participating in CAPACITY-COVID (Cardiac complicAtions in Patients With SARS Corona vIrus 2 regisTrY), from March 2020 to May 2021Participants All adults (aged ≥18 years), predominantly European, admitted to hospital with highly suspected covid-19 disease or covid-19 disease confirmed by positive laboratory test results (n=11 167 patients).Main outcome measures Any cardiovascular complication during admission to hospital. Secondary outcomes were in-hospital mortality and individual cardiovascular complications with ≥20 events for each sex. Logistic regression was used to examine sex differences in the risk of cardiovascular outcomes, overall and grouped by pre-existing cardiovascular disease.Results Of 11 167 adults (median age 68 years, 40% female participants) included, 3423 (36% of whom were female participants) had pre-existing cardiovascular disease. In both sexes, the most common cardiovascular complications were supraventricular tachycardias (4% of female participants, 6% of male participants), pulmonary embolism (3% and 5%), and heart failure (decompensated or de novo) (2% in both sexes). After adjusting for age, ethnic group, pre-existing cardiovascular disease, and risk factors for cardiovascular disease, female individuals were less likely than male individuals to have a cardiovascular complication (odds ratio 0.72, 95% confidence interval 0.64 to 0.80) or die (0.65, 0.59 to 0.72). Differences between the sexes were not modified by pre-existing cardiovascular disease; for the primary outcome, the female-to-male ratio of the odds ratio in those without, compared with those with, pre-existing cardiovascular disease was 0.84 (0.67 to 1.07).Conclusions In patients admitted to hospital for covid-19, female participants were less likely than male participants to have a cardiovascular complication. The differences between the sexes could not be attributed to the lower prevalence of pre-existing cardiovascular disease in female individuals. The reasons for this advantage in female individuals requires further research.

This article considers the use of photovoltaic converter energy for excitation of autonomous synchronous generators of small capacity. Autonomous power plants include mini hydro power plants, wind generators, diesel power plants, car generators, aircraft generators. Synchronous generators of these installations are initially excited from accumulator batteries and after operation of the generator from semiconductor rectifiers, the power supply of which is taken away from the generator stator.

Radia Tamarat and Susana Constantino Rosa Santos were not included as authors in the original publication [...]

Background Zwolle, TIMI, and GRACE risk scores have been proven to predict mayor adverse cardiovascular events (MACE) in STEMI patients undergoing primary percutaneous coronary intervention (PCI). However, they were developed over a long time ago which many advances have been made in the cardiovascular field today. The scores were also developed in the non-Asian majority population and their accuracy for Indonesian population remains unknown. We aimed to validate and compare these scores for Indonesian population. Methods An analytical observational study was conducted on 193 patients undergoing primary PCI. The Zwolle, GRACE, and TIMI risk scores were calculated for each patient. Then, the risk score validation was carried out with the calibration test using Hosmer Lemeshow test and discrimination test using the AUC ROC. Furthermore, the comparisons between the risk scores were carried out using the DeLong test. Results The three scores have good results in the Hosmer Lemeshow calibration test (p > 0.05). The discrimination test also indicated good results with AUC ROC Zwolle, TIMI and GRACE risk scores respectively 0.776; 0.782; 0.831 (p

The purpose of this research is to find out the superior Islamic education delivery system at MTsN 2 Bandar Lampung. This research method is a case study qualitative research. Data were obtained through interviews, documentation, and observation at MTs N 2 Bandar Lampung. Sources of interview data were obtained from school principals and curriculum deputy heads. Observations were made by direct observation at MTs N 2 Bandar Lampung and documentation by reviewing curricula and documents regarding the delivery of superior Islamic education. The results of the study concluded that the superior class at MTs N 2 Bandar Lampung was a class containing selected students who were selected based on strict conditions, namely academic potential, IQ, and student creativity which were adequate. The maintenance system is carried out by doing recruitment which consists of 2 paths, namely the achievement path and the regular path. Specifically, there are 3 (three) components of the superior program implemented in the superior class of MTs Negeri 2 Bandar Lampung, namely Academic Excellence, Moral Excellence, and Skill Excellence. Each component has special programs. Each component of the excellence program is expected to produce students who excel in their respective fields.

The purpose of the study was to determine the strategies of adolescent moral formation by collecting various research results in journal articles. This is intended for the younger generation to improve themselves and prepare them to build the nation in the future. This research is a systematic review through a review of journal articles about various ways of forming adolescent morals in obtaining Islamic adolescent characters. Article searches in Indonesian & English are accessed using the internet from the Google Scholar database, ScienceDirect, and many other article search engines. From this search, the keywords are moral formation strategies, youth, and the Qur'an. Data analysis using content analysis. The results of this review indicate that the moral formation of adolescents is very important in shaping the personality of adolescents and is expected to be able to build a nation with moral values that are guided by the Qur'an. Not only that, teenagers are also equipped with moral values to carry out their future lives.

This study aims to determine the yellow book learning method from the point of view of management science, including planning, organizing, implementing, and evaluating. This research uses the literature study method, in which researchers try to find data from various sources such as books, journals, and other research to compile, manage and present it to become information. Data collection techniques are carried out with documentation. Meanwhile, data analysis uses content analysis. The results showed that institutions applied five methods in teaching the yellow book at Islamic boarding schools, including sorogan, wetonan/bandongan, deliberation/ bahtsul Masa'il, market, Muhafadzoh, demonstrations, and classics. Islamic boarding schools and Madrasah Diniyyah generally implement institutions for learning the yellow book, a characteristic that cannot be separated from this learning is the large role of the Kiai (Teacher) and Santri (Students). Learning management that is applied other than the classical method needs to be carried out in writing and neatly. In contrast, the classical method is written and compiled in the bookkeeping of the Madrasah Diniyyah curriculum in Islamic boarding schools and Madrasah Diniyyah, which are independent outside Islamic schools. Thus the methodology of learning the yellow book in Islamic boarding schools is still conventional.

This study aims to describe the characteristics of learning in Islamic boarding schools. This research is qualitative with a literature approach. Research data is from learning characteristics in Islamic boarding schools with book and journal data sources. The collection technique is done by documentation. Meanwhile, data analysis uses content analysis. The study results show that the Islamic boarding school curriculum is more flexible. The curriculum is more oriented towards religious studies such as Nahwu, Sharaf, Ushul Fiqh, Mustalah Hadith, Tafsir, and Sufism. The curriculum in Islamic boarding schools is determined more by the kiai. Then the learning methods used in Islamic boarding schools include the band organ method, the slogan method, the discussion method, the rote method, the classical method, the demonstration method, the lecture method, and the question-and-answer method. Thus, Islamic boarding schools have different learning characteristics from other educational institutions.

This study aims to describe and conclude the results of Islamic education management studies for the period 2015 to 2022. This is qualitative-library research. Researchers conducted research on the results of research in journals related to the management of Islamic education in schools/madrasas from 2015-2022. The data and research data sources are in the form of "ten studies with the theme of MPI in madrasah schools”. Data sources were obtained from e-journals accessed from Google Scholar, ScienceDirect, and Elsevier. The sources sought are research results from 2015 to 2022. Data collection techniques use data collection by gathering as much information and data related to MPI. Using content analysis data analysis method. Based on a review of several studies on Islamic education management, researchers concluded that the success of Islamic education management is largely determined by the success of the human resources in it, both leaders, teachers, employees, or the community around the school/madrasah to achieve effective and efficient education. In this case, good management is needed in accordance with the rules and teachings contained in the Al-Qur'an and Hadith, while the management process of Islamic education includes planning Islamic education management, organizing Islamic education management, actuating Islamic education management, and controlling Islamic education management. In addition, in Islamic education management, there are Islamic education management principles that can be applied as a basis for decision-making.

Radiotherapy in cancer treatment involves the use of ionizing radiation for cancer cell killing. Although radiotherapy has shown significant improvements on cancer recurrence and mortality, several radiation-induced adverse effects have been documented. Of these adverse effects, radiation-induced cardiovascular disease (CVD) is particularly prominent among patients receiving mediastinal radiotherapy, such as breast cancer and Hodgkin’s lymphoma patients. A number of mechanisms of radiation-induced CVD pathogenesis have been proposed such as endothelial inflammatory activation, premature endothelial senescence, increased ROS and mitochondrial dysfunction. However, current research seems to point to a so-far unexamined and potentially novel involvement of epigenetics in radiation-induced CVD pathogenesis. Firstly, epigenetic mechanisms have been implicated in CVD pathophysiology. In addition, several studies have shown that ionizing radiation can cause epigenetic modifications, especially DNA methylation alterations. As a result, this review aims to provide a summary of the current literature linking DNA methylation to radiation-induced CVD and thereby explore DNA methylation as a possible contributor to radiation-induced CVD pathogenesis.

AbstractLysosomes are an important organelle required for the degradation of a range of cellular components. Lysosome function is critical for development and homeostasis as dysfunction can lead to inherited genetic disorders, cancer, and neurodegenerative and metabolic diseases. The acidic and protease-rich environment of lysosomes poses experimental challenges. Many fluorescent proteins are quenched or degraded, while specific red fluorescent proteins can be cleaved from translational fusion partners and accumulate. While studying MLT-11, a Caenorhabditis elegansC. elegansC. elegans

This article discusses the organizational dynamics of Muhammadiyah Islamic educational institutions. The purpose of this study is to find out how changes occur in the organization of Muhammadiyah Islamic educational institutions, including the factors that influence them and the programs developed to improve the quality and effectiveness of the education offered. Through socio-historical analysis with a historiographical approach, the factors influencing the development of this educational institution were identified, including political policies, social and cultural changes, technological developments, and Muhammadiyah’s educational thoughts and movements. Development programs developed to improve the quality of education are also reviewed, such as curriculum development, human resources, facilities and infrastructure, learning methods and technology, and cooperation with other educational institutions. The results of this study are that there are four dynamic periods of educational development in the Muhammadiyah organization, namely the pioneer period (1900-1923), the development period (1923-1/970), the development period (1923-1970), the institutionalization period (1970-1998), and the transformation period. (1998-present). In the 1970s, the development of Islamic education in the Muhammadiyah body began with the establishment of schools plus religion, which became the forerunner to the establishment of the Muhammadiyah Islamic Boarding School.

This research aims to reveal the role of Muslims in the establishment of madrasas in Indonesia, as well as the wider struggle for the spread of Islamic education in the country. The research method uses qualitative research that uses a historical methodological approach. Historical research is the methodical examination of records and other sources that contain information about the answers to historians' prehistoric questions. The results show that although the origin of madrasas in Indonesia has been the subject of much speculation, determining exactly when the name of the madrasa was first mentioned as a place of Islamic studies in Indonesia is still difficult to understand. However, it cannot be denied that madrasas or Islamic religious schools have appeared in Indonesia since the early 20th century. The conclusion obtained is that several Islamic groups, including Muhammadiyah, NU, and others, emerged in the early 20th century, coinciding with the rise of madrasas as places of teaching in Indonesia. The Ministry of Religion which was officially formed on 3 January 1946 had an important role in the growth of madrasas in the early years of independence. The politics of Islamic education in Indonesia is vigorously defended by this organization.

The purpose of this research is to acquire a deeper comprehension of Islamic boarding Schools, the traditional Islamic education system, as well as the function of kiai and tarekat as Indonesian religious authority figures. Boarding schools with a religious focus have been operating in Indonesia for hundreds of years, and they've had a significant impact on the development of Islamic education throughout the centuries. Kiai and tarekat are significant components of the traditional education system in Indonesia. They also play an essential part in the growth of Islamic knowledge and culture. The literature is analyzed through the lens of a descriptive methodology in this qualitative study. In order for researchers to obtain data, they must first analyze and assess the quantity of material and theory that has been offered by professionals in the field. This knowledge and theory may be located in the collections and archives of libraries in the form of books, articles from academic journals, periodicals, as well as various sources from the internet and other sources considered suitable to the subject that is being discussed. The analysis of research shows the results that pesantren are Islamic educational institutions that were born culturally from Indonesian culture and are therefore traditional, unique, and original which gives a different color to the education system in Indonesia which is able to provide repertoire and a very important role in fostering society. Islamic boarding Schools cannot function properly without the figure of a Kiai, who makes his presence an absolute requirement. Kiai is a manager who is capable of being a leader and able to regulate the rhythm of the development and survival of the pesantren with his expertise, depth of knowledge, charisma, and skills. Kiai, through the manifestation of tarekat teachings which characterize the value system of ahl al-sunnah wa al-jama'ah, has a significant influence on determining the pattern and trend of scientific traditions as well as the internal policies of Islamic boarding Schools.

This study expects to decide the job of pesantren, association, and presence of advanced education in creating Islamic instructive establishments in Indonesia. In this review utilizing the writing concentrate on a technique that depends on bibliographic sources from articles in the most recent diaries and books connected with the items in the primary issue. The consequences of the conversation show that: Islamic live-in schools are the verifiable foundations of Islamic training in Indonesia, despite the fact that it has not been said that formal schooling was legal at its beginning. Notwithstanding, the elements of the advancement of Islamic life experience in schools got an unprecedented welcome locally. This occurred during the Majapahit time frame. The job of associations, for example, social religion, schooling, and da'wah like Muhammadiyah, Nahdlatul Ulama (NU), Al-Irsyad, Jamiyyatul Al-Washliyah, and others, Islamic Training started to foster quickly in a cutting edge and contemporary heading. Advanced education in Indonesia, both Islamic and private, has shown its presence and is quite possibly of the best arrangement in the genuine states of Islamic Schooling as expressed by Muslim specialists and researchers, for example, Azyumardi Azra, As-Syaibany, A. Malik Fajar, and Muhammad Tliolhah Hasan.

Tujuan: Artikel ini bertujuan untuk menganalisis implementasi dan tindakan hukum yang dapat mengefektifkan pemenuhan kewajiban perpanjangan Tanda Daftar Usaha Pariwisata Hotel dalam kegiatan usaha hotel di Indonesia ditinjau dari peraturan perundang-undangan yang terkait. Metodologi: Metode penelitian yuridis normatif digunakan dalam penelitian ini untuk membahas permasalahan, yaitu menganalisis secara mendalam tentang peraturan-peraturan hukum positif yang bersangkutan dan juga penelitian lapangan terkait penerapan perpanjangan Tanda Daftar Usaha Pariwisata Hotel dalam penanaman modal. Temuan: Hasil penelitian menunjukan bahwa lemahnya pengawasan oleh pemerintah daerah dan dinas terkait menyebabkan terjadinya pelanggaran atas kewajiban perpanjangan Tanda Daftar Usaha Pariwisata Hotel. Pasca diterbitkannya Peraturan Pemerintah Nomor 24 Tahun 2018 tentang Pelayanan Perizinan Berusaha Terintegrasi Secara Elektronik oleh pemerintah pusat yang belum selaras dengan peraturan di daerah, juga menyebabkan ketidakpastian hukum. Pengaturan baru terkait penambahan biaya perizinan yang harus dikeluarkan, belum disesuaikan dengan kemampuan pengusaha di daerah. Pemerintah daerah dapat melakukan tindakan preventif dengan membentuk suatu dengar pendapat yang sistematis dan efektif serta menetapkan tindakan represif dalam bentuk uang jaminan (dwangsom) setelah pelaksanaan tindakan paksaan pemerintah sebelumnya sulit dilakukan. Kegunaan: Artikel ini dapat memberikan masukan bagi para pemangku kepentingan khususnya pemerintah pusat dan daerah berupa pemikiran baru untuk mengetahui bagaimana implementasi serta tindakan hukum yang dapat dilaksanakan dalam mengefektifkan pemenuhan kewajiban perpanjangan Tanda Daftar Usaha Pariwisata Hotel di Indonesia Kebaruan/Orisinalitas: Implementasi perpanjangan Tanda Daftar Usaha Pariwisata sangat berguna bagi pelaku usaha khususnya di bidang usaha hotel sebagai kontribusi pemikiran dan pengetahuan hukum khususnya mengenai permasalahan yang berkaitan dengan perpanjangan Tanda Daftar Usaha Pariwisata Hotel, khususnya ilmu di bidang hukum penanaman modal yang berkenaan dengan perizinan dalam penanaman modal.