17 results on '"Amsellem, Frederique"'
Search Results
2. Cortico-Cerebellar neurodynamics during social interaction in Autism Spectrum Disorders
- Author
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Gaudfernau, Fleur, Lefebvre, Aline, Engemann, Denis-Alexander, Pedoux, Amandine, Bánki, Anna, Baillin, Florence, Landman, Benjamin, Maruani, Anna, Amsellem, Frederique, Bourgeron, Thomas, Delorme, Richard, and Dumas, Guillaume
- Published
- 2023
- Full Text
- View/download PDF
3. Dépistage précoce des troubles du spectre autistique : symptômes émergents et bio-marqueurs
- Author
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Goussé, Véronique, Amsellem, Frédérique, and Delorme, Richard
- Published
- 2016
- Full Text
- View/download PDF
4. Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways
- Author
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Lefebvre, Aline, Tillmann, Julian, Cliquet, Freddy, Amsellem, Frederique, Maruani, Anna, Leblond, Claire, Beggiato, Anita, Germanaud, David, Amestoy, Anouck, Ly-Le Moal, Myriam, Umbricht, Daniel, Chatham, Christopher, Murtagh, Lorraine, Bouvard, Manuel, Leboyer, Marion, Charman, Tony, Bourgeron, Thomas, Delorme, Richard, Dumas, Guillaume, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Psychiatrie de l'enfant et de l'adolescent [Robert-Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Centre hospitalier Fondation Vallée [Gentilly, France] (CHS), Roche Pharma Research and Early Development [Basel] (pRED), F. Hoffmann-La Roche [Basel], Centre de Référence Déficiences Intellectuelles de causes rares / Rare Disease Reference Center for Intellectual Disability [CHU Robert Debré, AP-HP], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier Charles Perrens [Bordeaux], Fondation FondaMental [Créteil], Institut ROCHE [Boulogne-Billancourt], Roche S.A.S, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Pôle de Psychiatrie [Hôpital Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital H. Mondor - A. Chenevier, King‘s College London, Service psychiatrique de l'enfant et de l'adolescent [CHU Hôpital Robert Debré], Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], APHP, Autism Speaks, Autistica and Simons Foundation Autism Research Initiative, DHU protect, European Federation of Pharmaceutical Industries and Associations, European Federation of Pharmaceutical Industries and Associations companies, European Union's Horizon 2020, European Union's Seventh Framework Program, Grant/Award Number: FP7/2007-2013, Fondation a la Recherche Medicale, Fondation de France, Fondation FondaMental, French National Center for Scientific Research, Grant/Award Number: ANR-11-IDEX-0004-02 ANR-10-COHO-10-01 ANR-12-SAMA-0014, Innovative Medicines Initiative 2 Joint Undertaking Grant, Grant/Award Number: 777394, Innovative Medicines Initiative Joint Undertaking, Grant/Award Number: 115300, Innovative Medicines Initiative Joint Undertaking Grant, Institut National de la Santé et de la Recherche Médicale, Institut Pasteur, Grant/Award Number: C07-33, Investissements d'Avenir program, Labex BioPsy, Medical Research Foundation, Roche Institute for Research and Translational Medicine, EU-AIMS LEAP group, ANR-11-IDEX-0004,SUPER,Sorbonne Universités à Paris pour l'Enseignement et la Recherche(2011), ANR-12-SAMA-0014,AutoMobil,Encéphalite avec autoanticorps anti-récepteurs synaptiques : un nouveau modèle de troubles psychotiques(2012), ANR-10-COHO-0010,Psy-COH,FondaMental-Cohortes(2010), European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), European Project: 777394,H2020-JTI-IMI2-2016-10-two-stage,AIMS-2-TRIALS(2018), European Project: AIMS-2-TRIALS, Cliquet, Freddy, Sorbonne Universités à Paris pour l'Enseignement et la Recherche - - SUPER2011 - ANR-11-IDEX-0004 - IDEX - VALID, Santé Mentale et Addictions - Encéphalite avec autoanticorps anti-récepteurs synaptiques : un nouveau modèle de troubles psychotiques - - AutoMobil2012 - ANR-12-SAMA-0014 - SAMENTA - VALID, Cohortes - FondaMental-Cohortes - - Psy-COH2010 - ANR-10-COHO-0010 - COHO - VALID, European Autism Interventions - A Multicentre Study for Developing New Medications - EU-AIMS - - EC:FP7:SP1-JTI2012-04-01 - 2017-03-31 - 115300 - VALID, and Autism Innovative Medicine Studies-2-Trials - AIMS-2-TRIALS - INCOMING
- Subjects
GABA/glutamatergic pathway ,excitation and inhibition balance ,General Neuroscience ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.NEUR] Cognitive science/Neuroscience ,autism ,sensory profile ,autism spectrum disorder ,Neurology (clinical) ,clinical marker ,Genetics (clinical) - Abstract
International audience; As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum.
- Published
- 2023
5. Cortico-Cerebellar Neurodynamics during Social Interaction in Autism Spectrum Disorder
- Author
-
Gaudfernau, Fleur, primary, Lefebvre, Aline, additional, Engemann, Denis-Alexander, additional, Pedoux, Amandine, additional, Bánki, Anna, additional, Baillin, Florence, additional, Landman, Benjamin, additional, Amsellem, Frederique, additional, Bourgeron, Thomas, additional, Delorme, Richard, additional, and Dumas, Guillaume, additional
- Published
- 2022
- Full Text
- View/download PDF
6. Atypical social judgment and sensitivity to perceptual cues in autism spectrum disorders
- Author
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Forgeot d'Arc, Baudouin, Ramus, Franck, Lefebvre, Aline, Brottier, Delphine, Zalla, Tiziana, Moukawane, Sanaa, Amsellem, Frederique, Letellier, Laurence, Peyre, Hugo, Mouren, Marie-Christine, Leboyer, Marion, and Delorme, Richard
- Subjects
Pervasive developmental disorders -- Research -- Care and treatment -- Complications and side effects ,Human behavior -- Analysis ,Health - Abstract
Evaluation of faces is an important dimension of social relationships. A degraded sensitivity to facial perceptual cues might contribute to atypical social interactions in autism spectrum disorder (ASD). The current study investigated whether face based social judgment is atypical in ASD and if so, whether it could be related to a degraded sensitivity to facial perceptual cues. Individuals with ASD (n = 33) and IQ- and age-matched controls (n = 38) were enrolled in this study. Watching a series of photographic or synthetic faces, they had to judge them for 'kindness'. In synthetic stimuli, the amount of perceptual cues available could be either large or small. We observed that social judgment was atypical in the ASD group on photographic stimuli, but, contrarily to the prediction based on the degraded sensitivity hypothesis, analyses on synthetic stimuli found a similar performance and a similar effect of the amount of perceptual cues in both groups. Further studies on perceptual differences between photographs and synthetic pictures of faces might help understand atypical social judgment in ASD., Author(s): Baudouin Forgeot d'Arc[sup.1] [sup.2] [sup.5] [sup.6] [sup.7] , Franck Ramus[sup.1] , Aline Lefebvre[sup.1] , Delphine Brottier[sup.1] , Tiziana Zalla[sup.3] , Sanaa Moukawane[sup.1] , Frederique Amsellem[sup.2] , Laurence Letellier[sup.2] , [...]
- Published
- 2016
- Full Text
- View/download PDF
7. Episodic memory and self-awareness in Asperger Syndrome: Analysis of memory narratives
- Author
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Chaput, Valérie, Amsellem, Frédérique, Urdapilleta, Isabel, Chaste, Pauline, Leboyer, Marion, Delorme, Richard, and Goussé, Véronique
- Published
- 2013
- Full Text
- View/download PDF
8. Hypo- and hyper- sensory processing heterogeneity in Autism Spectrum Disorder
- Author
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Lefebvre, Aline, primary, Tillmann, Julian, additional, Cliquet, Freddy, additional, Amsellem, Frederique, additional, Maruani, Anna, additional, Leblond, Claire, additional, Beggiato, Anita, additional, Germanaud, David, additional, Amestoy, Anouck, additional, Moal, Myriam Ly-Le, additional, Umbricht, Daniel, additional, Chattam, Christopher, additional, Murtagh, Lorraine, additional, Bouvard, Manuel, additional, Leboyer, Marion, additional, Charman, Tony, additional, Bourgeron, Thomas, additional, Delorme, Richard, additional, and Dumas, Guillaume, additional
- Published
- 2021
- Full Text
- View/download PDF
9. 5 DIFFERENCES IN THE GENETIC BACKGROUND CONTRIBUTE TO RISK AND RESILIENCE TO AUTISM
- Author
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Rolland, Thomas, primary, Cliquet, Freddy, additional, Anney, Richard, additional, Mathieu, Alexandre, additional, Huguet, Guillaume, additional, Leblond, Claire, additional, Douard, Elise, additional, Fartek, Sandrine, additional, Maruani, Anna, additional, Amsellem, Frederique, additional, Packer, Alan, additional, Jacquemont, Sebastien, additional, Delorme, Richard, additional, and Bourgeron, Thomas, additional
- Published
- 2019
- Full Text
- View/download PDF
10. Alpha Waves as a Neuromarker of Autism Spectrum Disorder: The Challenge of Reproducibility and Heterogeneity
- Author
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Lefebvre, Aline, primary, Delorme, Richard, additional, Delanoë, Catherine, additional, Amsellem, Frederique, additional, Beggiato, Anita, additional, Germanaud, David, additional, Bourgeron, Thomas, additional, Toro, Roberto, additional, and Dumas, Guillaume, additional
- Published
- 2018
- Full Text
- View/download PDF
11. Gender differences in autism spectrum disorders: Divergence among specific core symptoms
- Author
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Beggiato, Anita, primary, Peyre, Hugo, additional, Maruani, Anna, additional, Scheid, Isabelle, additional, Rastam, Maria, additional, Amsellem, Frederique, additional, Gillberg, Carina I., additional, Leboyer, Marion, additional, Bourgeron, Thomas, additional, Gillberg, Christopher, additional, and Delorme, Richard, additional
- Published
- 2016
- Full Text
- View/download PDF
12. 11q24.2‐25 micro‐rearrangements in autism spectrum disorders: Relation to brain structures
- Author
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Maruani, Anna, primary, Huguet, Guillaume, additional, Beggiato, Anita, additional, ElMaleh, Monique, additional, Toro, Roberto, additional, Leblond, Claire S., additional, Mathieu, Alexandre, additional, Amsellem, Frederique, additional, Lemière, Nathalie, additional, Verloes, Alain, additional, Leboyer, Marion, additional, Gillberg, Christopher, additional, Bourgeron, Thomas, additional, and Delorme, Richard, additional
- Published
- 2015
- Full Text
- View/download PDF
13. Gender differences in autism spectrum disorders: Divergence among specific core symptoms.
- Author
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Beggiato, Anita, Peyre, Hugo, Maruani, Anna, Scheid, Isabelle, Rastam, Maria, Amsellem, Frederique, Gillberg, Carina I., Leboyer, Marion, Bourgeron, Thomas, Gillberg, Christopher, and Delorme, Richard
- Abstract
Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females ( P < 0.001) in the PARIS cohort, and 72.2% of males and 68.3% of females ( P < 0.0001) in the AGRE cohort. Among the items extracted by the stepwise DA, four belonged to the ADI-R algorithm used for the final diagnosis of ASD. In conclusion, several items of the ADI-R that are taken into account in the diagnosis of autism significantly differentiates between males and females. The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 680-689. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
14. Individuals with Autism Spectrum Disorders Do Not Use Social Stereotypes in Irony Comprehension
- Author
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Zalla, Tiziana, primary, Amsellem, Frederique, additional, Chaste, Pauline, additional, Ervas, Francesca, additional, Leboyer, Marion, additional, and Champagne-Lavau, Maud, additional
- Published
- 2014
- Full Text
- View/download PDF
15. Variations of the Candidate SEZ6L2 Gene on Chromosome 16p11.2 in Patients with Autism Spectrum Disorders and in Human Populations
- Author
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Konyukh, Marina, primary, Delorme, Richard, additional, Chaste, Pauline, additional, Leblond, Claire, additional, Lemière, Nathalie, additional, Nygren, Gudrun, additional, Anckarsäter, Henrik, additional, Rastam, Maria, additional, Ståhlberg, Ola, additional, Amsellem, Frederique, additional, Gillberg, I. Carina, additional, Mouren-Simeoni, Marie Christine, additional, Herbrecht, Evelyn, additional, Fauchereau, Fabien, additional, Toro, Roberto, additional, Gillberg, Christopher, additional, Leboyer, Marion, additional, and Bourgeron, Thomas, additional
- Published
- 2011
- Full Text
- View/download PDF
16. Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways.
- Author
-
Lefebvre A, Tillmann J, Cliquet F, Amsellem F, Maruani A, Leblond C, Beggiato A, Germanaud D, Amestoy A, Ly-Le Moal M, Umbricht D, Chatham C, Murtagh L, Bouvard M, Leboyer M, Charman T, Bourgeron T, Delorme R, and Dumas G
- Subjects
- Child, Humans, Sensation, Perception, Autistic Disorder genetics, Autism Spectrum Disorder genetics, Child Development Disorders, Pervasive
- Abstract
As an integral part of autism spectrum symptoms, sensory processing issues including both hypo and hyper sensory sensitivities. These sensory specificities may result from an excitation/inhibition imbalance with a poorly understood of their level of convergence with genetic alterations in GABA-ergic and glutamatergic pathways. In our study, we aimed to characterize the hypo/hyper-sensory profile among autistic individuals. We then explored its link with the burden of deleterious mutations in a subset of individuals with available whole-genome sequencing data. To characterize the hypo/hyper-sensory profile, the differential Short Sensory Profile (dSSP) was defined as a normalized and centralized hypo/hypersensitivity ratio from the Short Sensory Profile (SSP). Including 1136 participants (533 autistic individuals, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP), we observed a statistically significant dSSP mean difference between autistic individuals and controls, driven mostly by a high dSSP variability, with an intermediated profile represented by relatives. Our genetic analysis tended to associate the dSSP and the hyposensitivity with mutations of the GABAergic pathway. The major limitation was the dSSP difficulty to discriminate subjects with a similar quantum of hypo- and hyper-sensory symptoms to those with no such symptoms, resulting both in a similar ratio score of 0. However, the dSSP could be a relevant clinical score, and combined with additional sensory descriptions, genetics and endophenotypic substrates, will improve the exploration of the underlying neurobiological mechanisms of sensory processing differences in autism spectrum., (© 2022 International Society for Autism Research and Wiley Periodicals LLC.)
- Published
- 2023
- Full Text
- View/download PDF
17. Gender differences in autism spectrum disorders: Divergence among specific core symptoms.
- Author
-
Beggiato A, Peyre H, Maruani A, Scheid I, Rastam M, Amsellem F, Gillberg CI, Leboyer M, Bourgeron T, Gillberg C, and Delorme R
- Subjects
- Adolescent, Asperger Syndrome classification, Asperger Syndrome diagnosis, Autism Spectrum Disorder classification, Autistic Disorder classification, Autistic Disorder diagnosis, Child, Diagnostic Errors, Female, Humans, Male, Prevalence, Reference Values, Sex Factors, Autism Spectrum Disorder diagnosis
- Abstract
Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P < 0.001) in the PARIS cohort, and 72.2% of males and 68.3% of females (P < 0.0001) in the AGRE cohort. Among the items extracted by the stepwise DA, four belonged to the ADI-R algorithm used for the final diagnosis of ASD. In conclusion, several items of the ADI-R that are taken into account in the diagnosis of autism significantly differentiates between males and females. The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 680-689. © 2016 International Society for Autism Research, Wiley Periodicals, Inc., (© 2016 International Society for Autism Research, Wiley Periodicals, Inc.)
- Published
- 2017
- Full Text
- View/download PDF
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