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2. Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans

Author

Le Lay, Aurélie, Philippe, Erwann, Roth, Fanny, Sanchez-Archidona, Ana Rodriguez, Mehl, Florence, Denom, Jessica, Prasad, Rashmi, Asplund, Olof, Hansson, Ola, Ibberson, Mark, Andreelli, Fabrizio, Santoro, Lyse, Amouyal, Paul, Amouyal, Gilles, Brechot, Christian, Jamot, Laure, Cruciani-Guglielmacci, Céline, and Magnan, Christophe

Published
2022
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3. Regenerating Islet-Derived Protein 3α: A Promising Therapy for Diabetes. Preliminary Data in Rodents and in Humans

Author

Le Lay, Aurelie, primary, Philippe, Erwann, additional, Roth, Fanny, additional, Ana Rodriguez Sanchez-Archidona, Ana, additional, Mehl, Florence, additional, Prasad, Rashmi B., additional, Asplund, Olof, additional, Hansson, Ola, additional, Andreelli, Fabrizio, additional, Santoro, Lyse, additional, Amouyal, Paul, additional, Amouyal, Gilles, additional, Brechot, Christian, additional, Jamot, Laure, additional, Cruciani-Guglielmacci, Celine, additional, and Magnan, Christophe, additional

Published
2022
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6. 1064-P: The Human Recombinant REG3A Protein ALF-5755 Restores Glucose Homeostasis and Insulin Sensitivity in High-Fat Fed Mice and in Ob/Ob Mice

Author

DARNAUD, MARION, primary, CRUCIANI-GUGLIELMACCI, CÉLINE, additional, GONZALEZ, PATRICK, additional, AMOUYAL, PAUL, additional, AMOUYAL, GILLES, additional, JAMOT, LAURE, additional, MONIAUX, NICOLAS, additional, ANDREELLI, FABRIZIO, additional, BRÉCHOT, CHRISTIAN B., additional, MAGNAN, CHRISTOPHE, additional, and FAIVRE, JAMILA, additional

Published
2020
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10. Microsporidia infection in patients with the human immunodeficiency virus and unexplained cholangitis

Author

Pol, Stanislas, Romana, Christina A., Richard, Stephane, Amouyal, Paul, Desportes-Livage, Isabelle, Carnot, Francoise, Pays, Jean-Francois, and Dionysius of the Nativity, Blessed

Subjects
Cholangitis -- Causes of, AIDS (Disease) -- Complications, Microsporidia
Abstract

Infection of the biliary tract with the microsporidium Enterocytozoon (E.) bieneusi may cause some cases of AIDS-related cholangitis. Microsporidia are parasites, and cholangitis is an inflammation of the bile duct, suppressing the flow of bile and causing abdominal pain and fever. Most cases are attributed to infection with cytomegalovirus or cryptosporidia, but in about 40% of the cases of AIDS-related cholangitis there is no identifiable cause. Of eight, HIV-infected homosexual men with unexplained cholangitis, six showed signs of E. bieneusi infection. All eight patients had bile ducts infected with microsporidia. Microsporidial infection of the biliary tract is associated with homosexual behavior and severe immunodeficiency.

Published
1993

14. A Proof of Concept, Phase II Randomized European Trial, on the Efficacy of ALF-5755, a Novel Extracellular Matrix-Targeted Antioxidant in Patients with Acute Liver Diseases

Author

Nalpas, Bertrand, primary, Ichaï, Philippe, additional, Jamot, Laure, additional, Carbonell, Nicolas, additional, Rudler, Marika, additional, Mathurin, Philippe, additional, Durand, François, additional, Gerken, Guido, additional, Manns, Michael, additional, Trautwein, Christian, additional, Larrey, Dominique, additional, Radenne, Sylvie, additional, Duvoux, Christophe, additional, Leroy, Vincent, additional, Bernuau, Jacques, additional, Faivre, Jamila, additional, Moniaux, Nicolas, additional, Bréchot, Christian, additional, Amouyal, Gilles, additional, Amouyal, Paul, additional, and Samuel, Didier, additional

Published
2016
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17. HIP/PAP prevents excitotoxic neuronal death and promotes plasticity

Author

Haldipur, Parthiv, primary, Dupuis, Nina, additional, Degos, Vincent, additional, Moniaux, Nicolas, additional, Chhor, Vibol, additional, Rasika, Sowmyalakshmi, additional, Schwendimann, Leslie, additional, le Charpentier, Tifenn, additional, Rougier, Elodie, additional, Amouyal, Paul, additional, Amouyal, Gilles, additional, Dournaud, Pascal, additional, Bréchot, Christian, additional, El Ghouzzi, Vincent, additional, Faivre, Jamila, additional, Fleiss, Bobbi, additional, Mani, Shyamala, additional, and Gressens, Pierre, additional

Published
2014
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18. Endosonography: promising method for diagnosis of extrahepatic cholestasis

Author

Amouyal, Paul, Amouyal, Gilles, Mompount, Dominique, Gayet, Brice, Palazzo, Laurent, Ponsot, Philippe, Vilgrain, Valerie, Flejou, Jean-Francois, and Paolaggi, Joseph A.

Subjects
Diagnosis, Ultrasonic -- Evaluation, Cholestasis -- Diagnosis, Endoscopic ultrasonography -- Evaluation, Medical imaging equipment -- Evaluation
Published
1989

20. Prothrombin index slope is an early prognostic marker in patients with severe acute liver diseases: Figure 1

Author

Nalpas, Bertrand, primary, Francoz, Claire, additional, Ichaï, Philippe, additional, Jamot, Laure, additional, Faivre, Jamila, additional, Lemoinne, Sara, additional, Samuel, Didier, additional, Durand, François, additional, Bernuau, Jacques, additional, Bréchot, Christian, additional, Amouyal, Paul, additional, and Amouyal, Gilles, additional

Published
2011
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21. Human hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein cures fas-induced acute liver failure in mice by attenuating free-radical damage in injured livers

Author

Moniaux, Nicolas, primary, Song, Haiyan, additional, Darnaud, Marion, additional, Garbin, Kévin, additional, Gigou, Michelle, additional, Mitchell, Claudia, additional, Samuel, Didier, additional, Jamot, Laure, additional, Amouyal, Paul, additional, Amouyal, Gilles, additional, Bréchot, Christian, additional, and Faivre, Jamila, additional

Published
2010
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22. W1135 Biopsy of Pancreatic Endocrine Tumors (PETs) or of Their Liver Metastases Allows Accurate Characterization: A Comparison With Surgical Specimen Pathology

Author

Cordova, Jacqueline, primary, Couvelard, Anne, additional, Fabre, Monique, additional, Rebours, Vinciane, additional, Maire, Frédérique, additional, Palazzo, Laurent, additional, Amouyal, Gilles, additional, Amouyal, Paul, additional, Dokmak, Safi, additional, Sauvanet, Alain, additional, Aubert, Alain, additional, and Ruszniewski, Philippe B., additional

Published
2010
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25. Diagnosis of choledocholithiasis by endoscopic ultrasonography

Author

Amouyal, Paul, primary, Amouyal, Gilles, additional, Lévy, Philippe, additional, Tuzet, Sylvie, additional, Palazzo, Laurent, additional, Vilgrain, Valérie, additional, Gayet, Brice, additional, Belghiti, Jacques, additional, Fékété, François, additional, and Bernades, Pierre, additional

Published
1994
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26. AIDS-related cholangiopathy

Author

Benhamou, Yves, primary, Caumes, Eric, additional, Gerosa, Yves, additional, Cadranel, Jean François, additional, Dohin, Elisabeth, additional, Katlama, Christine, additional, Amouyal, Paul, additional, Canard, Jean Marc, additional, Azar, Nabih, additional, Hoang, Catherine, additional, Le Charpentier, Yves, additional, Gentilini, Marc, additional, Opolon, Pierre, additional, and Valla, Dominique, additional

Published
1993
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27. A Proof of Concept, Phase II Randomized European Trial, on the Efficacy of ALF-5755, a Novel Extracellular Matrix-Targeted Antioxidant in Patients with Acute Liver Diseases

Author

Nalpas, Bertrand, Ichaï, Philippe, Jamot, Laure, Carbonell, Nicolas, Rudler, Marika, Mathurin, Philippe, Durand, François, Gerken, Guido, Manns, Michael, Trautwein, Christian, Larrey, Dominique, Radenne, Sylvie, Duvoux, Christophe, Leroy, Vincent, Bernuau, Jacques, Faivre, Jamila, Moniaux, Nicolas, Bréchot, Christian, Amouyal, Gilles, Amouyal, Paul, and Samuel, Didier

Subjects
3. Good health
Abstract

PLoS one 11(3), e0150733 (2016). doi:10.1371/journal.pone.0150733, Published by PLoS, Lawrence, Kan.

29. Tumor suppressive role of the antimicrobial lectin REG3A targeting the O -GlcNAc glycosylation pathway.

Author

Moniaux N, Geoffre N, Deshayes A, Dos Santos A, Job S, Lacoste C, Nguyen TS, Darnaud M, Friedel-Arboleas M, Guettier C, Purhonen J, Kallijärvi J, Amouyal G, Amouyal P, Bréchot C, Vivès RR, Buendia MA, Issad T, and Faivre J

Abstract

Background and Aims: Antimicrobial proteins of the regenerating family member 3 alpha (REG3A) family provide a first line of protection against infections and transformed cells. Their expression is inducible by inflammation, which makes their role in cancer biology less clear since an immune-inflammatory context may preexist or coexist with cancer, as occurs in HCC. The aim of this study is to clarify the role of REG3A in liver carcinogenesis and to determine whether its carbohydrate-binding functions are involved., Approach and Results: This study provides evidence for a suppressive role of REG3A in HCC by reducing O -GlcNAcylation in 2 mouse models of HCC, in vitro cell studies, and clinical samples. REG3A expression in hepatocytes significantly reduced global O -GlcNAcylation and O -GlcNAcylation of c-MYC in preneoplastic and tumor livers and markedly inhibited HCC development in REG3A-c-MYC double transgenic mice and mice exposed to diethylnitrosamine. REG3A modified O -GlcNAcylation without altering the expression or activity of O-linked N-acetylglucosaminyltransferase, O-linked N-acetylglucosaminyl hydrolase, or glutamine fructose-6-phosphate amidotransferase. Reduced O -GlcNAcylation was consistent with decreased levels of UDP-GlcNAc in precancerous and cancerous livers. This effect was linked to the ability of REG3A to bind glucose and glucose-6 phosphate, suggested by a REG3A mutant unable to bind glucose and glucose-6 phosphate and alter O -GlcNAcylation. Importantly, patients with cirrhosis with high hepatic REG3A expression had lower levels of O -GlcNAcylation and longer cancer-free survival than REG3A-negative cirrhotic livers., Conclusions: REG3A helps fight liver cancer by reducing O -GlcNAcylation. This study suggests a new paradigm for the regulation of O -GlcNAc signaling in cancer-related pathways through interactions with the carbohydrate-binding function of REG3A., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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30. [HIP/PAP, a new drug for acute liver failure].

Author

Moniaux N, Darnaud M, Dos Santos A, Jamot L, Samuel D, Amouyal P, Amouyal G, Bréchot C, and Faivre J

Subjects
Acetaminophen toxicity, Acute Disease, Animals, Antigens, Neoplasm adverse effects, Antigens, Neoplasm therapeutic use, Biomarkers, Tumor adverse effects, Biomarkers, Tumor therapeutic use, Chemical and Drug Induced Liver Injury drug therapy, Chemical and Drug Induced Liver Injury etiology, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Disease Models, Animal, Drug Evaluation, Preclinical, Hepatitis etiology, Humans, Lectins, C-Type therapeutic use, Liver Regeneration, Mice, Mice, Inbred C57BL, Mice, Transgenic, Multicenter Studies as Topic, Pancreatitis-Associated Proteins, Reactive Oxygen Species metabolism, Recombinant Proteins adverse effects, Recombinant Proteins therapeutic use, fas Receptor agonists, Antigens, Neoplasm physiology, Biomarkers, Tumor physiology, Hepatitis drug therapy, Lectins, C-Type physiology, Liver Failure drug therapy
Published
2012
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