Search

Your search keyword '"Amoroso, C"' showing total 197 results
Start Over Author "Amoroso, C"
197 results on '"Amoroso, C"'

2. P981 Risankizumab, but not ustekinumab or vedolizumab, downregulates IL-23-induced mucosal pathogenic Th17 cells in patients with Crohn’s disease

Author

Noviello, D, primary, Dusetti, I, additional, Pivorunas, V, additional, Lovati, A E, additional, Ciafardini, C, additional, Amoroso, C, additional, Conforti, F, additional, Piazza O Sed, N, additional, Vecchi, M, additional, Facciotti, F, additional, Paroni, M, additional, and Caprioli, F, additional

Published
2024
Full Text
View/download PDF

3. P921 Maintenance of clinical, biochemical and transmural remission in inflammatory bowel disease patients switching from intravenous to subcutaneous infliximab

Author

Piazza O Sed, N, primary, Maregatti, M C, additional, Pessarelli, T, additional, Viganò, C, additional, Conforti, F, additional, Noviello, D, additional, Bezzio, C, additional, Amoroso, C, additional, Molteni, C, additional, Anolli, M P, additional, Pirola, L, additional, Saibeni, S, additional, Fraquelli, M, additional, Vecchi, M, additional, and Caprioli, F, additional

Published
2024
Full Text
View/download PDF

6. Gut Microbiota Manipulation as a Tool for Colorectal Cancer Management: Recent Advances in Its Use for Therapeutic Purposes

Author

Perillo, F, Amoroso, C, Strati, F, Giuffrè, M, Díaz-Basabe, A, Lattanzi, G, Facciotti, F, Perillo F, Amoroso C, Strati F, Giuffrè MR, Díaz-Basabe A, Lattanzi G, Facciotti F, Perillo, F, Amoroso, C, Strati, F, Giuffrè, M, Díaz-Basabe, A, Lattanzi, G, Facciotti, F, Perillo F, Amoroso C, Strati F, Giuffrè MR, Díaz-Basabe A, Lattanzi G, and Facciotti F

Abstract

Colorectal cancer (CRC) is a multifaceted disease influenced by both environmental and genetic factors. A large body of literature has demonstrated the role of gut microbes in promoting inflammatory responses, creating a suitable microenvironment for the development of skewed interactions between the host and the gut microbiota and cancer initiation. Even if surgery is the primary therapeutic strategy, patients with advanced disease or cancer recurrence after surgery remain difficult to cure. Therefore, the gut microbiota has been proposed as a novel therapeutic target in light of recent promising data in which it seems to modulate the response to cancer immunotherapy. The use of microbe-targeted therapies, including antibiotics, prebiotics, live biotherapeutics, and fecal microbiota transplantation, is therefore considered to support current therapies in CRC management. In this review, we will discuss the importance of host−microbe interactions in CRC and how promoting homeostatic immune responses through microbe-targeted therapies may be useful in preventing/treating CRC development.

Published
2020

7. The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation

Author

Amoroso, C, Perillo, F, Strati, F, Fantini, M, Caprioli, F, Facciotti, F, Amoroso C, Perillo F, Strati F, Fantini MC, Caprioli F, Facciotti F, Amoroso, C, Perillo, F, Strati, F, Fantini, M, Caprioli, F, Facciotti, F, Amoroso C, Perillo F, Strati F, Fantini MC, Caprioli F, and Facciotti F

Abstract

Alterations of the gut microbiota may cause dysregulated mucosal immune responses leading to the onset of inflammatory bowel diseases (IBD) in genetically susceptible hosts. Restoring immune homeostasis through the normalization of the gut microbiota is now considered a valuable therapeutic approach to treat IBD patients. The customization of microbe-targeted therapies, including antibiotics, prebiotics, live biotherapeutics and faecal microbiota transplantation, is therefore considered to support current therapies in IBD management. In this review, we will discuss recent advancements in the understanding of host-microbe interactions in IBD and the basis to promote homeostatic immune responses through microbe-targeted therapies. By considering gut microbiota dysbiosis as a key feature for the establishment of chronic inflammatory events, in the near future it will be suitable to design new cost-effective, physiologic, and patient-oriented therapeutic strategies for the treatment of IBD that can be applied in a personalized manner.

Published
2020

8. Intratumor Microbiome in Neuroendocrine Neoplasms: A New Partner of Tumor Microenvironment? A Pilot Study

Author

Massironi, S, Facciotti, F, Cavalcoli, F, Amoroso, C, Rausa, E, Centonze, G, Cribiu, F, Invernizzi, P, Milione, M, Cribiu, FM, Massironi, S, Facciotti, F, Cavalcoli, F, Amoroso, C, Rausa, E, Centonze, G, Cribiu, F, Invernizzi, P, Milione, M, and Cribiu, FM

Abstract

Neuroendocrine neoplasms (NENs) are rare neoplasms with heterogeneous clinical behavior. Alteration in human microbiota was reported in association with carcinogenesis in different solid tumors. However, few studies addressed the role of microbiota in NEN. We here aimed at evaluating the presence of bacterial infiltration in neuroendocrine tumoral tissue. To assess the presence of bacteria, 20 specimens from pancreatic NEN (pan-NEN) and 20 from intestinal NEN (I-NEN) were evaluated through Fluorescent In situ Hybridization and confocal microscopy. Demographic data, pre-operative investigations, operative findings, pathological diagnosis, follow-up, and survival data were evaluated. Among I-NEN, bacteria were detected in 15/20 (75%) specimens, with high variability in microbial distribution. In eight patients, a high infiltration of microorganisms was observed. Among pan-NEN, 18/20 (90%) showed microorganisms’ infiltration, with a homogeneous microbial distribution. Bacterial localization in pan-NEN was observed in the proximity of blood vessels. A higher bacterial infiltration in the tumoral specimen as compared with non-tumoral tissue was reported in 10/20 pan-NEN (50%). No significant differences were observed in mean bacterial count according to age, sex, ki67%, site, tumor stage. Mean bacterial count did not result to be a predictor of disease-specific survival. This preliminary study demonstrates the presence of a significant microbiota in the NEN microenvironment. Further research is needed to investigate the potential etiological or clinical role of microbiota in NEN.

Published
2022

9. Tumor infiltrating iNKT cells sustain neutrophil pro-tumorigenic functions influencing disease progression in human colorectal cancer

Author

Lattanzi, Georgia, Lattanzi, G, Strati, F, Díaz-Basabe, A, Perillo, F, Amoroso, C, Protti, G, Giuffrè, M, Baldari, L, Cassinotti, E, Ghidini, M, Galassi, B, Lopez, G, Noviello, D, Porretti, L, Trombetta, E, Mazzarella, L, Iezzi, G, Nicassio, F, Granucci, F, Caprioli, F, Facciotti, F, Lattanzi, Georgia, Strati, Francesco, Díaz-Basabe, Angélica, Perillo, Federica, Amoroso, Chiara, Protti, Giulia, Giuffrè, Maria Rita, Baldari, Ludovica, Cassinotti, Elisa, Ghidini, Michele, Galassi, Barbara, Lopez, Gianluca, Noviello, Daniele, Porretti, Laura, Trombetta, Elena, Mazzarella, Luca, Iezzi, Giandomenica, Nicassio, Francesco, Granucci, Francesca, Caprioli, Flavio, Facciotti, Federica, Lattanzi, Georgia, Lattanzi, G, Strati, F, Díaz-Basabe, A, Perillo, F, Amoroso, C, Protti, G, Giuffrè, M, Baldari, L, Cassinotti, E, Ghidini, M, Galassi, B, Lopez, G, Noviello, D, Porretti, L, Trombetta, E, Mazzarella, L, Iezzi, G, Nicassio, F, Granucci, F, Caprioli, F, Facciotti, F, Lattanzi, Georgia, Strati, Francesco, Díaz-Basabe, Angélica, Perillo, Federica, Amoroso, Chiara, Protti, Giulia, Giuffrè, Maria Rita, Baldari, Ludovica, Cassinotti, Elisa, Ghidini, Michele, Galassi, Barbara, Lopez, Gianluca, Noviello, Daniele, Porretti, Laura, Trombetta, Elena, Mazzarella, Luca, Iezzi, Giandomenica, Nicassio, Francesco, Granucci, Francesca, Caprioli, Flavio, and Facciotti, Federica

Published
2022

10. Microbiota-targeted therapies in inflammation resolution

Author

Strati, F, Lattanzi, G, Amoroso, C, Facciotti, F, Strati, Francesco, Lattanzi, Georgia, Amoroso, Chiara, Facciotti, Federica, Strati, F, Lattanzi, G, Amoroso, C, Facciotti, F, Strati, Francesco, Lattanzi, Georgia, Amoroso, Chiara, and Facciotti, Federica

Abstract

Gut microbiota has been shown to systemically shape the immunological landscape, modulate homeostasis and play a role in both health and disease. Dysbiosis of gut microbiota promotes inflammation and contributes to the pathogenesis of several major disorders in gastrointestinal tract, metabolic, neurological and respiratory diseases. Much effort is now focused on understanding host-microbes interactions and new microbiota-targeted therapies are deeply investigated as a means to restore health or prevent disease. This review details the immunoregulatory role of the gut microbiota in health and disease and discusses the most recent strategies in manipulating individual patient's microbiota for the management and prevention of inflammatory conditions.

Published
2022

12. Additional file 2 of Transcriptomic and genomic analysis provides new insights in molecular and genetic processes involved in zucchini ZYMV tolerance

Author

Amoroso, C. G., Andolfo, G., Capuozzo, C., Di Donato, A., Martinez, C., Tomassoli, L., and Ercolano, M. R.

Abstract

Additional file 2: Additional Figure 1. Gel electrophoretic separation of digested PCR products (left 381e, right TF); panel A: LG01SNP1; panel B: LG08SNP4. Relevant fragment sizes (bp) are denoted on the right side (1Kb plus). Additional Figure 2. Comparison of the ZYMV tolerant line 381e (left) and the susceptible True French (right) 12 days after ZYMV inoculation.

Published
2022
Full Text
View/download PDF

14. Transcriptomic and genomic analysis provides new insights in molecular and genetic processes involved in zucchini ZYMV tolerance

Author

Amoroso, C G, Andolfo, G, Capuozzo, C, Di Donato, A, Martinez, C, Tomassoli, L, Ercolano, M, Amoroso, C G, Andolfo, G, Capuozzo, C, Di Donato, A, Martinez, C, Tomassoli, L, and Ercolano, M

Subjects
Potyvirus, Plant Disease, Genomics, Molecular marker, Plant viru, Plant Viruses, Cucurbita pepo, Cucurbita, Genomic, Genetics, RNA-seq, Plant recovery, Plant Viruse, Transcriptome, Biotechnology, Plant Diseases
Abstract

Background Cucurbita pepo is highly susceptible to Zucchini yellow mosaic virus (ZYMV) and the resistance found in several wild species cannot be considered as complete or broad-spectrum resistance. In this study, a source of tolerance introgressed in C. pepo (381e) from C. moschata, in True French (TF) background, was investigated 12 days post-inoculation (DPI) at transcriptomic and genomic levels. Results The comparative RNA-sequencing (RNA-Seq) of TF (susceptible to ZYMV) and 381e (tolerant to ZYMV) allowed the evaluation of about 33,000 expressed transcripts and the identification of 146 differentially expressed genes (DEGs) in 381e, mainly involved in photosynthesis, transcription, cytoskeleton organization and callose synthesis. By contrast, the susceptible cultivar TF triggered oxidative processes related to response to biotic stimulus and activated key regulators of plant virus intercellular movement. In addition, the discovery of variants located in transcripts allowed the identification of two chromosome regions rich in Single Nucleotide Polymorphisms (SNPs), putatively introgressed from C. moschata, containing genes exclusively expressed in 381e. Conclusion 381e transcriptome analysis confirmed a global improvement of plant fitness by reducing the virus titer and movement. Furthermore, genes implicated in ZYMV tolerance in C. moschata introgressed regions were detected. Our work provides new insight into the plant virus recovery process and a better understanding of the molecular basis of 381e tolerance.

Published
2020

18. PRS62 Applying Multiple Criteria Decision Analysis (MCDA) to Assess the VALUE of Budesonide-Formoterol Maintenance and Reliever Therapy in Asthma- an Empirical Case Study

Author

Aiello, A., primary, Amoroso, C., additional, Berto, P., additional, Canonica, G.W., additional, Cattani, L., additional, Cicchetti, A., additional, Coratella, G., additional, Di Marco, F., additional, Fedriga, A.L., additional, Lombardo, F.P., additional, Maffezzoli, S., additional, Manna, G., additional, Ruggeri, I., additional, Saleri, C., additional, Samaha, D., additional, Trifirò, G., additional, and Ubertazzo, L., additional

Published
2020
Full Text
View/download PDF

22. Cyberbullismo e videopeer education

Author

LAVANCO, Gioacchino, NOVARA, Cinzia, Amoroso, C., Lavanco, G, Novara, C, and Amoroso, C

Subjects
cyberbullismo, bullismo tradizionale, prevenzione, video peer education, nuove realtà gruppali, moderne dimensioni educative, Settore M-PSI/07 - Psicologia Dinamica
Abstract

Lo scopo di questo articolo – attraverso un processo di ricerca-azione che coinvolge un cam-pione di 243 soggetti pre-adolescenti ed adolescenti – è quello di sottolineare come il mezzo in-formatico può essere causa di aggressioni, molestie, offese; ma allo stesso tempo, utilizzato come fonte di nuove strategie comunicative, di interazione gruppale e di intervento educativo in comunità virtuali. Il cyberbullismo si materializza nella vita delle vittime in ogni momento della giornata e at-traverso diverse realtà (video, foto, mail, chatroom, sms, chiamate telefoniche, ecc). Uno dei metodi di prevenzione, che guarda alle dinamiche di gruppo ed alle tecnologie mediali come fonte educative, è la video peer education. L’utilizzo di materiali online come metodo di prevenzione e sensibilizzazione delle agenzie educative e degli stessi fautori e/o vittime del cyberbullismo.

Published
2014

26. Preoperative sonographic features of borderline ovarian tumors

Author

Exacoustos, C, Romanini, M, Rinaldo, D, Amoroso, C, Szabolcs, B, Zupi, E, and Arduini, D

Subjects
Adult, Adolescent, Cystadenoma, Adenocarcinoma, Sensitivity and Specificity, Diagnosis, Differential, Diagnosis, Preoperative Care, 80 and over, Humans, Mucinous, Neoplasm Invasiveness, Child, Ultrasonography, Aged, Retrospective Studies, Aged, 80 and over, Ovarian Neoplasms, Cystadenoma, Serous, Doppler, Serous, Ultrasonography, Doppler, Middle Aged, Adenocarcinoma, Mucinous, Postmenopause, Premenopause, Differential, Settore MED/40 - Ginecologia e Ostetricia, Female
Abstract

To determine the sonographic findings that distinguish borderline ovarian tumors (BOT) from both benign and invasive malignant tumors, thus allowing conservative treatment and laparoscopic management of these tumors.We reviewed retrospectively transvaginal sonograms of 33 women who, when evaluated further by surgery and histology, were found to have BOT. Twenty-three were premenopausal and 10 were postmenopausal (mean age +/- SD, 45.8 +/- 15.7 years). For each mass, size and morphological features and power Doppler characteristics were evaluated. We compared these findings with those of 337 patients with benign ovarian tumors and those of 82 patients with invasive malignant ovarian tumors. Patients with dermoid cysts were not included in the study.Of the 33 BOT, 15 were mucinous and 18 were serous cystadenomas. The presence of papillae, defined as a small number of solid tissue projections, 1-15 mm in height and 1-10 mm in width (base) and length (base), into the cyst cavity from the cyst wall, was significantly more frequent in BOT (48%) than it was in benign (4%) and invasive (4%) malignant tumors. Intracystic solid tissue (15 mm in height or10 mm in width or length) was observed in 48% of invasive malignant masses but in only 18% of BOT and in 7% of benign tumors (P0.001). No sonographically unilocular, hypoechoic, smooth-walled adnexal cysts were invasively malignant but three unilocular cysts with a diameter of6 cm were serous BOT. Although close attention was paid to the cyst wall at ultrasound examination we did not observe in these three cysts the very small papillae which were found at histological analysis.The most frequent diagnostic feature on imaging BOT is the presence of papillae within the cyst. However, neither papillae nor other sonographic features constituted highly sensitive sonographic markers of BOT.

Published
2004

47. 159

Author

Exacoustos, C., primary, Amadio, A., additional, Romanini, M., additional, Amoroso, C., additional, Szabolcs, B., additional, Zupi, E., additional, and Arduini, D., additional

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results