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1. Sonothrombolysis in acute middle cerebral artery stroke

Author

Mahmoud Haroun, Ahmed ElSadek, Azza Abdel Nasser, Samia Ashour, Ramez Reda Moustafa, Mohamed Hamdy Ibrahim, and Amira Zaki Dwedar

Subjects
Adult, Male, medicine.medical_specialty, Ultrasonography, Doppler, Transcranial, Fibrinolytic Agents, Internal medicine, medicine.artery, Occlusion, medicine, Humans, In patient, cardiovascular diseases, Acute ischemic stroke, Aged, Aspirin, business.industry, Stroke scale, Clinical course, Infarction, Middle Cerebral Artery, Middle Aged, Surgery, Stroke, Treatment Outcome, Neurology, Middle cerebral artery, cardiovascular system, Cardiology, Female, Neurology (clinical), Middle cerebral artery stroke, business, Blood Flow Velocity, medicine.drug
Abstract

Objectives: The objective of the following study is to determine the effect of continuous insonation using 2-MHz transcranial Doppler-ultrasound (TCD-US) on the recanalization rate and the short-term outcome in subjects with acute ischemic stroke due to middle cerebral artery (MCA) occlusion. Materials and Methods: A total of 42 patients with acute ischemic stroke due to MCA occlusion within 24 h were recruited and randomly allotted to two groups (21 patients in each group). Group 1 included patients who received 1 h continuous TCD-US for MCA and Group 2 included patients who did not receive 1 h continuous TCD-US. Patients in both groups were received MCA insonation and TCD study to measure mean flow velocity (MFV) in MCA one after the initial study at 20 and 60 min. All patients received aspirin (150-325 mg). The clinical course during hospital stay was assessed before and after 1 h of US insonation, at 24 h after symptom onset using the National Institutes of Health Stroke Scale. Results: Change in MFV after insonation for Group 1 in comparison to Group 2 at 3 time points was significantly high (P < 0.001). Conclusion: Sonothrombolysis is a therapeutic option to improve the outcomes in patients with acute ischemic stroke due to MCA occlusion.

Published
2014

2. Sonothrombolysis in acute middle cerebral artery stroke.

Author

Amira Zaki Dwedar, Ashour, Samia, Haroun, Mahmoud, Azza Abd El Nasser, Ramez Reda Moustafa, Mohamed Hamdy Ibrahim, and Elsadek, Ahmed

Subjects
*CEREBRAL arterial diseases, *STROKE, *ULTRASONIC imaging, *DOPPLER ultrasonography, *NEUROLOGICAL research
Abstract

Objectives: The objective of the following study is to determine the effect of continuous insonation using 2-MHz transcranial Doppler-ultrasound (TCD-US) on the recanalization rate and the short-term outcome in subjects with acute ischemic stroke due to middle cerebral artery (MCA) occlusion. Materials and Methods: A total of 42 patients with acute ischemic stroke due to MCA occlusion within 24 h were recruited and randomly allotted to two groups (21 patients in each group). Group 1 included patients who received 1 h continuous TCD-US for MCA and Group 2 included patients who did not receive 1 h continuous TCD-US. Patients in both groups were received MCA insonation and TCD study to measure mean flow velocity (MFV) in MCA one after the initial study at 20 and 60 min. All patients received aspirin (150-325 mg). The clinical course during hospital stay was assessed before and after 1 h of US insonation, at 24 h after symptom onset using the National Institutes of Health Stroke Scale. Results: Change in MFV after insonation for Group 1 in comparison to Group 2 at 3 time points was significantly high (P < 0.001). Conclusion: Sonothrombolysis is a therapeutic option to improve the outcomes in patients with acute ischemic stroke due to MCA occlusion. [ABSTRACT FROM AUTHOR]

Published
2014
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