8,324 results on '"Amiot, A."'
Search Results
2. Invariants of persistence modules defined by order-embeddings
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Amiot, Claire, Brüstle, Thomas, and Hanson, Eric J.
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Mathematics - Algebraic Topology ,Mathematics - Representation Theory - Abstract
One of the main objectives of topological data analysis is the study of discrete invariants for persistence modules, in particular when dealing with multiparameter persistence modules. In many cases, the invariants studied for these non-totally ordered posets $P$ can be obtained from restricting a given module to a subposet $X$ of $P$ that is totally ordered (or more generally, of finite representation type), and then computing the barcode (or the general direct sum decomposition) over $X$. We consider in this paper general order-preserving embeddings of representation-finite subposets $X$ into $P$ and study systematically the invariants obtained by decomposing the restriction of a given $P$-module $M$ to $X$ into its indecomposable summands. The restriction functor from $\mathrm{mod} \ P$ to $\mathrm{mod} \ X$ is well-studied, and it is known to be exact and admits both left and right adjoint functors, known as induction and co-induction functors. This allows us to obtain new homological insights, and also to re-interpret previous results. We use this approach also to determine bases, thus generalizing the concept of signed barcodes which is considered in the literature in relation to stability results. It turns out that considering only order-embeddings of one fixed poset $X$ into the poset $P$, and studying the set of all indecomposables obtained from $X$ introduces a lot of redundancy. We therefore also study iterated embeddings of several posets of increasing sizes, while limiting attention to only some indecomposables (that have not been obtained from embedding of smaller posets previously)., Comment: 22 pages
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- 2024
3. Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities
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Kamal H. Hussein, Boyukkhanim Ahmadzada, Julio Cisneros Correa, Ahmer Sultan, Silvana Wilken, Bruce Amiot, and Scott L. Nyberg
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Bioengineered liver ,Decellularization ,Recellularization ,Reendothelialization ,Biliary reconstruction ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Liver transplantation represents the only definitive treatment for patients with end-stage liver disease. However, the shortage of liver donors provokes a dramatic gap between available grafts and patients on the waiting list. Whole liver bioengineering, an emerging field of tissue engineering, holds great potential to overcome this gap. This approach involves two main steps; the first is liver decellularization and the second is recellularization. Liver decellularization aims to remove cellular and nuclear materials from the organ, leaving behind extracellular matrices containing different structural proteins and growth factors while retaining both the vascular and biliary networks. Recellularization involves repopulating the decellularized liver with appropriate cells, theoretically from the recipient patient, to reconstruct the parenchyma, vascular tree, and biliary network. The aim of this review is to identify the major advances in decellularization and recellularization strategies and investigate obstacles for the clinical application of bioengineered liver, including immunogenicity of the designed liver extracellular matrices, the need for standardization of scaffold fabrication techniques, selection of suitable cell sources for parenchymal repopulation, vascular, and biliary tree reconstruction. In vivo transplantation models are also summarized for evaluating the functionality of bioengineered livers. Finally, the regulatory measures and future directions for confirming the safety and efficacy of bioengineered liver are also discussed. Addressing these challenges in whole liver bioengineering may offer new solutions to meet the demand for liver transplantation and improve patient outcomes.
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- 2024
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4. Crop diversity used in branded products with focus on legume species worldwide
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Tristan Salord, Marie-Benoît Magrini, Valérie Lullien-Pellerin, Guillaume Cabanac, Marie-Joseph Amiot, Cécile Barron, Adeline Boire, Valérie Micard, and Magalie Weber
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Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
Abstract Food diversity is a challenging issue for sustainable agrifood systems. Diets are increasingly dependent on branded packaged foods. Therefore, the crop diversity offered in the food market through these products is of particular importance. We scrutinize this diversity for some crops under great societal challenge: pulses. Based on the product launches referenced in the Mintel database over the last decade, we compare the food products containing pulse crops with those containing another legume—soy. From the 350,000 products analyzed, our results show that soy is mainly used but reveal some progress in the use of pulse species, particularly in Europe. The position of the examined species in the list of ingredients and in the product description allows us to assess its importance. The text-mining methods used usefully enable the monitoring of crop usage in the food market. We discuss several perspectives, notably how to deepen these results regarding consumer choices.
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- 2024
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5. COVID-19 infection and 2-year mortality in nursing home residents who survived the first wave of the pandemic
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Manuel Sanchez, Pauline Courtois-Amiot, Vincent Herrault, Hélène Allart, Philippe Eischen, Fabienne Chetaille, Denise Lepineux, Castille de Cathelineau, and Agathe Raynaud-Simon
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COVID-19 ,Long-term mortality ,Nursing homes ,Older adults ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background During the first COVID-19 pandemic wave (1st CoPW), nursing homes (NHs) experienced a high rate of COVID-19 infection and death. Residents who survived the COVID-19 infection may have become frailer. This study aimed to determine the predictive value of having a COVID-19 infection during the 1st CoPW for 2-year mortality in NH residents. Methods This was a retrospective study conducted in three NHs. Residents who had survived the 1st CoPW (March to May 2020) were included. The diagnosis of COVID-19 was based on the results of a positive reverse transcriptase-polymerase chain reaction test. The collected data also included age, sex, length of residence in the NH, disability status, legal guardianship status, nutritional status, need for texture-modified food, hospitalization or Emergency Department visits during lockdown and SARS-COV2 vaccination status during the follow-up. Non-adjusted and adjusted Cox models were used to analyse factors associated with 2-year post-1st CoPW mortality. Results Among the 315 CoPW1 survivors (72% female, mean age 88 years, 48% with severe disability), 35% presented with COVID-19. Having a history of COVID-19 was not associated with 2-year mortality: hazard ratio (HR) [95% confidence interval] = 0.96 [0.81–1.13], p = 0.62. The factors independently associated with 2-year mortality were older age (for each additional year, HR = 1.05 [1.03–1.08], p
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- 2024
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6. Why Sines?
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Amiot, Emmanuel
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- 2024
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7. Crop diversity used in branded products with focus on legume species worldwide
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Salord, Tristan, Magrini, Marie-Benoît, Lullien-Pellerin, Valérie, Cabanac, Guillaume, Amiot, Marie-Joseph, Barron, Cécile, Boire, Adeline, Micard, Valérie, and Weber, Magalie
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- 2024
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8. COVID-19 infection and 2-year mortality in nursing home residents who survived the first wave of the pandemic
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Sanchez, Manuel, Courtois-Amiot, Pauline, Herrault, Vincent, Allart, Hélène, Eischen, Philippe, Chetaille, Fabienne, Lepineux, Denise, de Cathelineau, Castille, and Raynaud-Simon, Agathe
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- 2024
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9. Environmental impact and nutritional quality of adult diet in France based on fruit and vegetable intakes
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Komati, Nathalie, Vieux, Florent, Maillot, Matthieu, Darmon, Nicole, Calvarin, Johanna, Lecerf, Jean-Michel, Amiot, Marie-Josèphe, Belzunces, Luc, and Tailliez, Delphine
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- 2024
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10. Implementation of lung ultrasonography by general practitioners for lower respiratory tract infections: a feasibility study
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Félix Amiot, Thomas Delomas, François-Xavier Laborne, Thomas Ecolivet, Richard Macrez, and Axel Benhamed
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General practice ,primary care ,family medicine ,point-of-care ultrasound ,lung ultrasonography ,Public aspects of medicine ,RA1-1270 - Abstract
Objective To evaluate the feasibility of lung ultrasonography (LUS) performed by novice users’ general practitioners (GPs) in diagnosing lower respiratory tract infections (LRTIs) in primary health care settings.Design A prospective interventional multicenter study (December 2019–March 2020).Settings and subjects Patients aged >3 months, suspected of having LRTI consulting in three different general practices (GPs) (rural, semirural and urban) in France.Main outcome measures Feasibility of LUS by GPs was assessed by (1) the proportion of patients where LUS was not performed, (2) technical breakdowns, (3) interpretability of images by GPs, (4) examination duration and (5) patient perception and acceptability.Results A total of 151 patients were recruited, and GPs performed LUS for 111 (73.5%) patients (LUS group). In 99.1% (n = 110) of cases, GPs indicated that they were able to interpret images. The median [IQR] exam duration was 4 [3–5] minutes. LRTI was diagnosed in 70.3% and 60% of patients in the LUS and no-LUS groups, respectively (p = .43). After LUS, GPs changed their diagnosis from ‘other’ to ‘LRTI’ in six cases (+5.4%, p
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- 2024
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11. C2OMODO: A Tandem of Innovative Radiometers for High Resolution All-Sky Atmospheric Sounding as Part of the AOS Mission.
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Laura Hermozo, Jérôme Puech, Hélène Brogniez, Rémy Roca, Thomas Fiolleau, Jean-Pierre Chaboureau, Franck Auguste, Dominique Bougniol, Julien Delanoë, Thierry Amiot, Nathalie Steunou, Rocio Redondo, Xavier Boulanger, Roseline Schmisser, Benjamin Carayon, Samuel Melle, Christophe Malassingne, Laurent Costes, Jean-Claude Orlhac, Adrien Moraine, Stephane Le Drogo, Carole Tucker, Peter Ade, Ian Walker, Jeanne Treuttel, Gregory Gay 0003, Lina Gatilova, Alexandre Feret, Thibaut Vacelet, and Jean-Michel Krieg
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- 2024
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12. Of All Interval Tetrachords and Octatonic Scales.
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Emmanuel Amiot and Tom Johnson
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- 2024
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13. Of All Interval Tetrachords and Octatonic Scales
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Amiot, Emmanuel, Johnson, Tom, Hartmanis, Juris, Founding Editor, Goos, Gerhard, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Noll, Thomas, editor, Montiel, Mariana, editor, Gómez, Francisco, editor, Hamido, Omar Costa, editor, Besada, José Luis, editor, and Martins, José Oliveira, editor
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- 2024
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14. Biofortification versus diversification to fight micronutrient deficiencies: an interdisciplinary review
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Malézieux, Eric, Verger, Eric O., Avallone, Sylvie, Alpha, Arlène, Ngigi, Peter Biu, Lourme-Ruiz, Alissia, Bazile, Didier, Bricas, Nicolas, Ehret, Isabelle, Martin-Prevel, Yves, and Amiot, Marie Josèphe
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- 2024
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15. Introducing compression platen misalignment in single fiber transverse compression analytical models
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Govilas, Jason, Guicheret-Retel, Violaine, Clévy, Cédric, Placet, Vincent, and Amiot, Fabien
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- 2023
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16. BCLXL PROTAC degrader DT2216 targets secondary plasma cell leukemia addicted to BCLXL for survival.
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Champion, Ophélie, Soler, Alana, Maïga, Sophie, Bellanger, Céline, Pellat-Deceunynck, Catherine, Touzeau, Cyrille, Amiot, Martine, Gomez-Bougie, Patricia, and Talbot, Alexis
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BCL2 family ,BCLXL degrader ,DT2216 ,PROTAC ,multiple myeloma ,plasma cell leukemia - Abstract
Secondary plasma cell leukemia (sPCL) is a rare form of aggressive plasma cell malignancy arising mostly at end-stage refractory multiple myeloma and consequently presenting limited therapeutic options. We analyzed 13 sPCL for their sensitivity to BH3 mimetics targeting either BCL2 (venetoclax) or BCLXL (A1155463) and showed that 3 sPCL were efficiently killed by venetoclax and 3 sPCL by A1155463. Accordingly, BH3 profiling of 2 sPCL sensitive to BCLXL inhibition confirmed their high BCLXL primed profile. While targeting BCLXL using BH3 mimetics induces platelets on-target drug toxicity, the recent development of DT2216, a clinical-stage BCLXL proteolysis targeting chimera PROTAC compound, provides an alternative strategy to target BCLXL. Indeed, DT2216 specifically degrades BCLXL via VHL E3 ligase, without inducing thrombocytopenia. We demonstrated in human myeloma cell lines and sPCL that sensitivity to DT2216 strongly correlated with the sensitivity to A1155463. Interestingly, we showed that low doses of DT2216 (nM range) were sufficient to specifically degrade BCLXL after 48 hours of treatment, consistent with VHL expression, in all cell lines but irrespectively to DT2216 sensitivity. In myeloma cells, DT2216 induced apoptotic cell death and triggered BAX and BAK activation. In conclusion, our study demonstrated that patients with sPCL addicted to BCLXL, a small but a very challenging group, could potentially receive therapeutic benefit from DT2216. Clinical trials of DT2216 in this subset of sPCL patients are warranted.
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- 2023
17. Identifying suicidal risk factors in the French Overseas Territories with multimethod psychological autopsy (AUTOPSOM): a mixed-methods study protocol
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Louis Jehel, Maya Amiot, Stéphane Amadéo, Sylvie Merle, Mathieu Guidère, Monique Seguin, and Michel Spodenkiewicz
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Medicine - Abstract
Introduction Understanding suicide in more isolated territories is a challenge because of the entanglement of cultural identity with historical, geographical and sociocultural specificities. This knowledge is a necessary precondition for the implementation of targeted prevention strategies in regions such as the French overseas territories (FOT), where data concerning suicidal risk factors is still incomplete. We aim to untangle sociocultural and clinical suicide risk factors by integrating a novel anthropological and psycholinguistic approach into the psychological autopsy method. This article describes the protocol of the clinical study ‘Contribution of Psychological Autopsy to the Understanding of Suicidal Behaviours in Overseas France’ (AUTOPSOM study), designed to identify common or new specific suicide risk factors in four FOT.Methods and analysis A multicentre epidemiological study will be carried out in four FOTs (French Polynesia, Martinique, La Reunion and French Guiana) and at a comparison site in mainland France (La Somme). The methodology will be based on a mixed-methods (quantitative and qualitative) approach using a psychological autopsy to collect clinical data and life events in the deceased’s life. We implemented an exploratory multimethod strategy that combines a succession of epidemiological, anthropological, psycholinguistic and psychological methods with a semiautomated analysis of the discourse of relatives bereaved by suicide.Ethics and dissemination The study protocol (first version) was approved by the French Ethics Committee (CPP OUEST II, approval #22.04267.000122) and the Ethics Committee of French Polynesia (JOPF of 5 April 2022; CEPF opinion n°91 of 29 March 2022). The overall results and the perspectives established at the end of the study will be communicated to the bereaved relatives according to their will and serve for local suicide prevention purposes.Trial registration number NCT05773898.
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- 2024
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18. Prospective Acceptability of Digital Therapy for Major Depressive Disorder in France: Multicentric Real-Life Study
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Odile Amiot, Anne Sauvaget, Isabelle Alamome, Samuel Bulteau, Thomas Charpeaud, Anne-Hélène Clair, Philippe Courtet, Dominique Drapier, Emmanuel Haffen, Eric Fakra, Christian Gaudeau-Bosma, Adeline Gaillard, Stéphane Mouchabac, Fanny Pineau, Véronique Narboni, Anne Duburcq, and Laurent Lecardeur
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Medicine - Abstract
BackgroundMajor depressive disorder is one of the leading causes of disability worldwide. Although most international guidelines recommend psychological and psychosocial interventions as first-line treatment for mild to moderate depression, access remains limited in France due to the limited availability of trained clinicians, high costs for patients in the context of nonreimbursement, and the fear of stigmatization. Therefore, online blended psychological treatment such as Deprexis could improve access to care for people with depression. It has several advantages, such as easy accessibility and scalability, and it is supported by evidence. ObjectiveThis study aims to evaluate the real-life acceptability of Deprexis for people with depression in France outside of a reimbursement pathway. MethodsDeprexis Acceptability Study Measure in Real Life (DARE) was designed as a multicenter cross-sectional study in which Deprexis was offered to any patient meeting the inclusion criteria during the fixed inclusion period (June 2022-March 2023). Inclusion criteria were (1) depression, (2) age between 18 and 65 years, (3) sufficient French language skills, and (4) access to the internet with a device to connect to the Deprexis platform. Exclusion criteria were previous or current diagnoses of bipolar disorder, psychotic symptoms, and suicidal thoughts during the current episode. The primary objective was to measure the prospective acceptability of Deprexis, a new digital therapy. Secondary objectives were to examine differences in acceptability according to patient and clinician characteristics and to identify reasons for refusal. All investigators received video-based training on Deprexis before enrollment to ensure that they all had the same level of information and understanding of the program. ResultsA total of 245 patients were eligible (n=159, 64.9% were women and n=138, 56.3% were single). The mean age was 40.7 (SD 14.1) years. A total of 78% (n=191) of the patients had moderate to severe depression (according to the Patient Health Questionnaire-9 [PHQ-9]). More than half of the population had another psychiatric comorbidity (excluding bipolar disorder, psychotic disorders, and suicidal ideation). A total of 33.9% (n=83) of patients accepted the idea of using Deprexis; the main reason for refusal was financial at 83.3% (n=135). Multivariate logistic regression identified factors that might favor the acceptability of Deprexis. Among these, being a couple, being treated with an antidepressant, or having a low severity level favored the acceptance of Deprexis. ConclusionsDARE is the first French study aiming at evaluating the prospective acceptability of digital therapy in the treatment of depression. The main reason for the refusal of Deprexis was financial. DARE will allow better identification of factors influencing acceptability in a natural setting. This study highlights the importance of investigating factors that may be associated with the acceptability of digital interventions, such as marital status, medication use, and severity of depression.
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- 2024
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19. The effects of polystyrene microparticles on the environmental availability and bioavailability of As, Cd and Hg in soil for the land snail Cantareus aspersus
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Colpaert, Romain, de Vaufleury, Annette, Rieffel, Dominique, Amiot, Caroline, Crini, Nadia, and Gimbert, Frédéric
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- 2024
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20. Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities
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Hussein, Kamal H., Ahmadzada, Boyukkhanim, Correa, Julio Cisneros, Sultan, Ahmer, Wilken, Silvana, Amiot, Bruce, and Nyberg, Scott L.
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- 2024
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21. Producing human livers from human stem cells via blastocyst complementation
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Ahmadzada, Boyukkhanim, Felgendreff, Philipp, Minshew, Anna M., Amiot, Bruce P., and Nyberg, Scott L.
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- 2024
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22. Infliximab is an effective option in patients with ulcerative colitis previously exposed to full subcutaneous anti-TNF agent: Results from a real-world multicenter study
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Hupé, M., Streichenberger, A., Wils, P., Arab, N., Serrero, M., Amiot, A., Bozon, A., Vuitton, L., Fumery, M., Altwegg, R., Nachury, M., Hébuterne, X., Yzet, C., Coban, D., Dodel, M., Bazoge, M., Pereira, B., and Buisson, A.
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- 2024
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23. Metals in the Réunion harrier: tissue concentrations and meaning for conservation
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Hadjadji, Cloé, Augiron, Steve, Crini, Nadia, Amiot, Caroline, Driget, Vincent, Tourmetz, Julie, Renault, Samantha, and Coeurdassier, Michael
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- 2023
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24. Targeted surgery combined with postoperative medical therapy for residual disease for severe and multifocal Crohn disease
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Lelièvre, Océane, Abdalla, Solafah, Carbonnel, Franck, Amiot, Aurélien, Meyer, Antoine, Penna, Christophe, Benoist, Stéphane, and Brouquet, Antoine
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- 2024
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25. The Inca child of the Quehuar volcano: Stable isotopes clue to geographic origin and seasonal diet, with putative seaweed consumption
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Poulallion, Eve, Galván, Violeta A. Killian, Seldes, Verónica, Zigarán, María Fernanda, Browning, Gabriela Recagno, Fourel, François, Clauzel, Thibault, Flandrois, Jean-Pierre, Séon, Nicolas, Simon, Laurent, Amiot, Romain, and Lécuyer, Christophe
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- 2024
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26. Listeria monocytogenes-associated spontaneous bacterial peritonitis in France: a nationwide observational study of 208 cases
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Abdou, Mohamed, Abdulhai, Ayman, Abdulhal, Ayman, Abel, Samy, Abergel, Armand, Aberrane, Saïd, Abraham, Bruno, Adler, Maxime, Agard, Christian, Agha-Mir, Ilhem, Aguilar, Claire, Agulles, Baptiste, Aldallal, Hamza, Alric, Laurent, Amiot, Xavier, Andrau, Pierre, Andrieux, Vladimir, Ansart, Séverine, Anty, Rodolphe, Archambeaud, Isabelle, Arem, Samir, Armand, Laurence, Aubailly, Lucie, Audibert, Juliette, Auguereau, Olivier, Auvray, Christelle, Aziz, Karime, Bachelier, Marie-Nadège, Bacquaert-Dufour, Karine, Badet, Françoise, Bahallah, Mohamed-Larbi, Balanant, Hélène, Baraduc, Régine, Bardis, Alexandre, Barraud, Olivier, Barrier, Jocelyn, Baudet, Antoine, Baumert, Thomas, Beaugerie, Laurent, Bébéar, Cécile, Becheur, Hakim, Bemer, Pascale, Benard, Caroline, Benezet, Marie-Pierre, Benmahammed, Mohammed, Bennouna, Jaafar, Benseddik, Zehaira, Bensimon, Pierre-Yves, Bental, Abdeslam, Berete, Aliou, Bergier, Jean-Michel, Berkani, Wacila, Bernardi, Franck, Bert, Frederic, Bertrou, Anne, Beuret, Pascal, Beurton-Chataigner, Isabelle, Beuscart, Claude, Beusnel, Christine, Bevilacqua, Sibylle, Beze, François, Bideau, Karine, Bidegain, Frédéric, Billon, Laura, Blaison, Gilles, Blanc, Michèle, Blanc, Pierre, Blanchi, Sophie, Blancho, Gilles, Bland, Stephane, Blondeau, Vincent, Boldron, Amale, Bon, Djemah, Bonacorsi, Stéphane, Bonzon, Lucas, Borderon, Anaïs, Botelho-Nevers, Elisabeth, Bottlaender, Jacques, Bouc-Boucher, Mathilde, Bouchaud, Olivier, Bougon, David, Boukelikha, Khaled, Bourlet, Thomas, Boussoukaya, Samy, Boutaleb, Hamza, Bouziges, Nicole, Bray, Philippe, Bréchet, Caroline, Bret, Laurent, Brieu, Nathalie, Briffaut, David, Brochet, Christine, Brulez-Des-Varannes, Stanislas, Brunel, Valéry, Brung-Lefebvre, Maud, Bureau, Christophe, Burucoa, Christophe, Buscail, Louis, Buzele, Rodolphe, Cadot, Catherine, Cadranel, Jean-Francois, Cady, Anne, Caillon, Jocelyne, Camiade, Sabine, Campillo, Bernard, Carbonnel, Franck, Carbonnelle, Etienne, Cardot-Martin, Émilie, Cariou, Marie-Estelle, Carles, Michel, Caron, Francois, Carrara-Delarue, Lucrecia, Carrier, Paul, Castang, Céline, Castellano, Inès, Cattoir, Vincent, Caubet, Olivier, Causse, Xavier, Chabrol, Amélie, Chanard, Emmanuel, Chatagnon, Thomas, Chazouilleres, Olivier, Chedanni, Halima, Chevrel, Pauline, Chirol, Catherine, Chirouze, Catherine, Chouquer, Renaud, Clavière, Christophe, Codreuil, Sylvain, Colardelle, Philippe, Combarnous, François, Commeau, Grégory, Cornillet, Anne, Corvec, Stephane, Costa, Yannick, Couderc, Philippe, Couffon, Caroline, Courivaud, Cécile, Courtade, Henri, Cruchant, Etienne, Cuen, David, Culard, Jean-François, Cung, Hong Ahn, Dahyot, Sandrine, D'Altéroche, Louis, Dao, Manh Thông, Darfeuil, Fabien, Darnaud, Céline, Daure, Sophie, De Grossouvre-Taillefer, Ludivine, Debriel, Dominique, Debrueres, Jacques, Decaens, Thomas, Decambron, Audrey, Decre-Grapinet, Dominique, Degand, Nicolas, Dehaye, Bruno, Delacour, Thierry, Delarbe, Jean-Marie, Delobel, Pierre, Delpierre, Éric, Delrez, René, Delvert, Didier, Demartino, Sylvie, Deniel, Marie-Clémence, Denis, Bernard, Derumeaux, Guy, Desroches, Marine, Dessein, Rodrigue, Devillez, Simon, Deweerdt, Didier, Diamantis, Sylvain, Diaz, Emmanuel, Didier, Raffenot, Dimartino, Vincent, Dion, Ludivine, Djemai, Mohand, Doche, Christophe, Donascimento, Maud, Dorval, Ian, Douala, Carol, Doucet-Populaire, Florence, Drouillat, Valérie, Dubée, Vincent, Dudermel, Anne-France, Dumont, Betty, Dupin, Clarisse, Dupont, Mathieu, Dupont, Philippe, Dupuy, Marion, Dupuychaffray, Jean-Pierre, Durand, Francois, Dusser, Pascale, Duval, Valérie, Duveau, Nicolas, El-Azouzi, Abdelghani, El-Gharras, Hynd, Elsendoorn, Antoine, Emile, Loïc, Epaulard, Olivier, Etchepare, Nicolas, Etienne, Jean-Pierre, Eveillard, Mathieu, Evers, Annie, Fach, Joelle, Faizoun, Claudia, Fangous, Marie-Sarah, Farmachidi, Jean Pierre, Fatome, Armelle, Faulques, Bernard, Faure, Karine, Felix, Charlotte, Ferec, Marc, Ferey, Janine, Ferracci, Serge, Feryn, Jean-Marc, Fesler, Pierre, Fiette, Hélène, Flevin, Emilie, Floch, Pauline, Fort, Eric, Fortineau, Nicolas, Fourcade, Jacques, Fraissinet, François, Franck, Patricia, Françoise, Thiebaut, Fratte, Serge, Galempoix, Jean-Marc, Garcera, Yves, Garcia, Anne, Garcon, Pierre, Garret, Charlotte, Gayet, Clement, Gazeau, Pierre, Gerber, Florence, Gilles, Raclot, Gillot, Jean-Michel, Goarant, Eric, Godreuil, Sylvain, Goret, Julien, Gorret, Julie, Goujard, Cecile, Goulenok, Thiphaine, Gournay, Jérôme, Gousseff, Marie, Goux, Alain, Graf, Emmanuelle, Grange, Jean-Didier, Gravet, Alain, Greder-Belan, Alix, Gronier, Olivier, Grosset, Marine, Guellouz, Sabra, Guenenna, Dalida, Guerbaa, Mohammed, Guerin, Meggie, Guerrot, Dominique, Guery, Benoit, Gugenheim, Jean, Guidet, Bertrand, Guiheneuf, Raphael, Guillet-Caruba, Christelle, Guimard, Yves, Guinard, Jérome, Guindre, Laure, Hagege, Albert, Hagege, Hervé, Haineaux, Paul-Arthur, Hamon, Rémy, Hassan, Firas, Hassine, Mélanie, Helie, Ludovic, Herber-Mayne, Anne, Hervio, Pascale, Héry-Arnaud, Geneviève, Hitoto, Hikombo, Hubsch, Théophile, Hunaut, Nicolas, Hurtova, Monika, Husson-Wetzel, Stéphanie, Hutin, Pascal, Izopet, Théo, Jacob, Jean-Louis, Jacomet, Christine, Jaffar-Bandjee, Marie-Christine, Janvier, Fréderic, Jaulhac, Benoît, Jaureguiberry, Stephane, Javaud, Nicolas, Jeannot, Katty, Joundy, Noureddine, Kacem, Moez, Karama, Rouis, Karsenti, David, Kempf, Marie, Khatibi, Sarah, Kikolski, Florence, Kittirath, Christine, Koch, Stephane, Kouatchet-Achille, Tchamba, Krummel, Yves, La Combe, Karine, Labarriere, Damien, Laberenne, Jean-Eric, Lacroix, Hervé, Ladrat, Laure, Lagarde, Stéphanie, Lagasse, Jean-Paul, Laggoune, Ahmed-Saïd, Lambare, Benedicte, Landgraf, Nathalie, Landraud, Luce, Laude, Jean-Francois, Laurent, François, Lavigne, Jean-Philippe, Lavoue, Vincent, Le Berre, Rozenn, Le Goff, Vallérie, Lebars, Hervé, Lebrun, Armandine, Lecapitaine, Anne-Lise, Lechat, Sylvie, Lecoustumier, Alain, Ledreau, Gérard, Lefevre, Benjamin, Leflon, Véronique, Lefort, Agnès, Legall, Florence, Legoff, Isabelle, Legrand, Eric, Lehello, Simon, Le-Henaff-Bourhis, Catherine, Leleu, Olivier, Lelievre, Lucie, Lemaignen, Adrien, Lemaire, Xavier, Le-Maout, Charles, Lemblé, Chantal, Lemeille, Yolande, Lemenand, Olivier, Lemeunier, Violaine, Lemeur, Yannick, Lemierre, Sylvia, Leotard, Sophie, Lepileur, Lucie, Letellier-Demonchy, Claire, Levecq, Hervé, Levy, Marc, Limal, Nicolas, Locher, Christophe, Lopez, Benjamin, Loron, Marie-Charlotte, Loulergue, Joelle, Loury-Larivière, Isabelle, Loustaud-Ratti, Véronique, Macchi, Valèrie, Machado, Moise, Madaule, Serge, Mainardi, Jean-Luc, Males, Silvija, Malherbe, Philippe, Maneglier, Benjamin, Marceau, Maryline, Marcel, Kévin, Marmonier, Alain, Martha, Benoît, Martin, Xavier, Martin-Blondel, Guillaume, Martinez, Camille, Marty, Fabrice, Marty, Patrick, Matray, Olivier, Maurin, Arnaud, Mazerand, Sandie, Mazouz, Nadia, Medevielle, Muriel, Mercat, Alain, Méreghetti, Laurent, Merzoug, Noureddine, Meziane, Ilham, Michaud, Anthony, Michel, Marc, Michel, Pierre, Mignard, Sophie, Milesi-Lecat, Anne-Marie, Mion, Mathieu, Mnasri, Nabil, Mohareb, Abdo, Mohib, Samir, Moindrot, Henri, Monlun, Eric, Montewis, Audrey, Morin, Thierry, Moussata, Driffa, Muller, Sandrine, Muzellec, Valérie, Nancey, Stéphane, Nassereddine, Ahmad, Naude, Sebastien, Neau, Didier, Ovidiu, Negru Calin, Ngo, Thuy, Ngwhotue, Marthe-Andree, Nivet, Patrick, Nordmann, Patrice, Nousbaum, Jean-Baptiste, Nouvel, Bernadette, Obled, Stephane, Oswald, Eric, Otto, Marie-Pierre, Pageaux, Georges-Philippe, Papin, Gregory, Parant, Fabrice, Patenotte, Arnaud, Paupard, Thierry, Pauwels, Arnaud, Pawlotsky, Jean Michel, Pelloux, Hervé, Perlemuter, Gabriel, Peron, Jean-Marie, Pestel-Caron, Martine, Peter, Natasha, Petillon, Sophie, Petit, Richard, Petitprez, Helene, Pettinelli, Francois, Phelip, Jean Marc, Philit, Jean-Baptiste, Phoutthasang, Valérie, Pialoux, Gilles, Piau-Couapel, Caroline, Pichard, Benoit, Pichon, Maxime, Picon-Coste, Magali, Picque, Marie, Pierson, Henri, Piques, Jean Francois, Piton, Béatrice, Planade, Orianne, Plassart, Claire, Plésiat, Patrick, Ploy, Marie-Cécile, Poubeau, Patrice, Pouderoux, Philippe, Pouedras, Pascal, Pourbaix, Annabelle, Poynard, Thierry, Preau, Florence, Pricope, Dumitrita, Queffelec, Gwenaëlle, Queneherve, Lucille, Quentin, Thomas, Raffenot, Didier, Rakotoniaina, Daniella, Ramanantsoa, Celine, Ramarijaona, Solofoniaina, Rami-Arab, Lila, Raulin, Olivia, Rebibou, Jean Michel, Renault, David, Rey, Philippe, Riche, Agnès, Rigaud, Jean Philippe, Rivière, Antoine, Rivière, Brigitte, Robert, Jérôme, Roblot, Pascal, Roger, Helene, Rolland, Christophe, Rondinaud, Emilie, Rosa-Hezode, Isabelle, Roubille, Martine, Rouquette, Olivier, Roux, Juliette, Ruimy, Raymond, Sachot-Ollivier, Sonia, Sailler, Laurent, Salamant, Sarah, Sarbu-Pop, Silvia, Sartre, Jacques, Schmitt, François, Scribe-Outtas, Myriam, Sefrioui, David, Sehouane, Rachid, Sekhri, Hacène, Serfaty, Lawrence, Sevin, Odile, Shawali, Cédric, Siladi, Souad, Silvain, Christine, Simon, Mireille, Simonet, Batiste, Sinayoko, Leila, Sirach, Estelle, Smati, Mustafa, Smets, Aurélie, Soltani, Dhaoui, Sommabere, André, Soulier-Guerin, Karine, Soulillou, Jean Paul, Soupison, Alain, Souply, Laurent, Soussy, Claude-James, Stampfli, Claire, Strullu, Bernard, Suatean, Diana, Tadjerouni, Nacer, Talarmin, Jean-Philippe, Tankovic, Jacques, Tarroun, Abdullah, Tchuenbou, Juliette, Teboul, Jean-Louis, Tedlaouti, Husni, Tellini, Charlotte, Thabut, Dominique, Thannberger, Philippe, Thiebault, Henri, Thiebaut, Françoise, Thomazeau, Joséphine, Tielman, Guillaume, Timsit, Jean-Francois, Tognon, Patrick, Tougeron, David, Toure, Fatouma, Tran, Albert, Tranvouez, Jean-Luc, Trésallet, Christophe, Trubert, Lise, Tsakiris, Laurent, Twizeyimana, Eterne, Vachee, Anne, Valade, Hélène, Valat, Isabelle, Vandendriessche, Anne, Vandermee, Nathalie, Vanheste, Marc, Varon, Emmanuelle, Vasse, Marc, Vasseur, Philippe, Vaucel, Elisabeth, Vauthier, Anne, Verdavaine-Loidreau, Delphine, Verdet, Charlotte, Verdon, Renaud, Vergnaud, Michel, Véziris, Nicolas, Vignaud, Guillaume, Viguier, Jérôme, Villemain, Marc, Villeneuve, Laurent, Vimont-Vicary, Alexandre, Vincent, Thomas, Vuillemenot, Jean-Baptiste, Walewski, Violaine, Warmoes, Elodie, Watry, Hélène, Weber, Jean-Christophe, Witz, Marie Thérèse, Woerther, Paul-Louis, Yazdanpanah, Yazdan, Zamfir, Oana, Zarka, Jonathan, Zavadil, Patrick, Zeboudj, Nabil, Zerbib, Franck, Blanchard, Florian, Henry, Benoît, Vijayaratnam, Sofieya, Canouï, Etienne, Moura, Alexandra, Thouvenot, Pierre, Bracq-Dieye, Hélène, Tessaud-Rita, Nathalie, Valès, Guillaume, Diakité, Andrée, Leclercq, Alexandre, Lecuit, Marc, and Charlier, Caroline
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- 2024
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27. Strategy to secure the neuraxial route in anaesthesia: Risk mapping and feedback from the application of the ISO 80369-6 standard NRFit® connectors
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Amiot, Jeanice, Bruge Ansel, Marie Hélène, Bruyas, Mathilde, Rinaudo, Marc, Rulliat, Emilie, Gauthier, Jérôme, Piriou, Vincent, and Cabelguenne, Delphine
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- 2024
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28. An innovative method for measuring the convective cooling of photovoltaic modules
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Amiot, Baptiste, Pabiou, Hervé, Le Berre, Rémi, and Giroux–Julien, Stéphanie
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- 2024
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29. Exploring the role of our contacts with pets in broadening concerns for animals, nature, and fellow humans: a representative study
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Amiot, Catherine E., Gagné, Christophe, and Bastian, Brock
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- 2023
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30. Exploring participant’s experiences in a multifamily therapy group on schizophrenia : a qualitative approach
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O. Amiot, C. Genis, L. Champlon, S. Said, and L. Baziret
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Psychiatry ,RC435-571 - Abstract
Introduction Prevention of relapse in schizophrenia is a major public health issue. A recent network meta-analysis investigating interventions for relapse prevention in schizophrenia found that the efficacity of family psychoeducation and systemic integrated interventions were superior to treatment as usual at 12 months (Bighelli I, Leucht S et al. Lancet Psychiatry 2021). Other studies also found that multi-family therapies (MFT) were superior to treatment as usual and family psychoeducation in preventing relapses at 2 and 4 years (McFarlane WR, Lukens EP et al. Archives of General Psychiatry.1995). Considering this, we developped in our community center an MFT program based on systemic approach and psychoeducation. Objectives Investigate the subjective experience of participants of an MFT group focusing on schizophrenia. Methods A qualitative study was designed to explore personal experience of participants using the Interpretative Phenomenological Analysis (IPA) method in order to analyse participant’s feedback during semi-directive interviews. By using IPA, participants are experts of their experience. Eight participants took part in this study: 4 patients and 4 parents. Results Within all participant’s feedback around 10 different themes emerged. We identified three major themes which we have described as: “Affiliation to the group”, “Framework of Discovery”, “Benefits of MFT”. According to “Affiliation to the group”, all participants report movements of adhesion or rejection towards the group. This theme has been subdivided into two sub-themes: “Temporality”, and “Identification/differentiation”. These sub-themes revealed inter-individuals’ differences. According to “Framework of discovery”, the MFT group has been identified as a secure place allowing self and other’s discovery place. This theme has been divided into two sub-themes: “discovering skills” and “improving oneself and relatives’ understanding”. Participants experience taking a step back and decentering oneself from usual personnal position. According to “Benefits of MFT”, participants report the feeling of belonging to a group, the impact on self-esteem, on mentalization skills, and on the reflexion on family members’ experience of the disease. Conclusions This study is, to our knowledge, the first qualitative study examining the subjective experience of members who participated in a psychoeducational and systemic MFT group focusing on schizophrenia. It provides insight into the families’ experience, both from the patient’s and from each family member’s perspective. Results highlight that participants seized the MFT group as a learning space at several levels: personal, intra-family and inter-family. These data could enlighten professionals working with families on the potential apprehensions of participants, their representations of the group and what process MFT could initiate. Disclosure of Interest None Declared
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- 2024
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31. Who benefits from multifamily psychoeducation groups ? Descriptive anaysis of participants
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O. Amiot, C. Genis, L. Baziret, L. Champlon, and S. Saïd
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Psychiatry ,RC435-571 - Abstract
Introduction Guidelines for relapse prevention in schizophrenia recommend psychoeducation for patients and caregivers (Bighelli I, Leucht S et al. Lancet Psychiatry 2021). Considering that, in 2021, we implemented in our Psychiatric community center a multifamily therapy (MFT). The program is based on systemic approach and psychoeducation, focusing on schizophrenia. Objectives Describe participants of MFT groups focusing on schizophrenia. * Patients’ characteristics : age, gender, duration of psychiatric follow-up, history of hospitalization * Caregivers’ characterics: status, age. Methods We carried out a descriptive study of the different profile of MFT groups participants in our community center from 2021 to today. Results Since 2021, 4 MFT groups took place including 50 participants: 18 patients suffering from schizophrenia and 32 relatives. Image 1 illustrates the different participants of each group. Each group was different. Some patients came with both their parents, even if divorced, some came only with their mother. Some came with a sibling. Nevertheless, the numbers of fathers and siblings did not always allow us to work in sub-groups. Considering patients: 18 patients benefited from our program. 8 female and 10 male patients (55.6%) were admitted and distributed in each group as described in image 2. The mean age of patients was 31.9 years old [20.1 – 57.5]. Each group was made up of patients with psychiatric follow-up ranging from 1 year to more than 20 years, and having experienced between 1 to more than 5 psychiatric hospitalizations. It appears that Group 4 was noticeably younger than the other groups with a mean age of 22.4 years old [20.4 – 26.7] and a shorter history in psychiatry with less hospitalisations (image 3). Considering relatives: 15 mothers, 9 fathers, 5 siblings, 1 spouse, 1 aunt and 1 uncle benefited from psychoeducation to caregivers. The relatives were from 47 to 81 years old for the parents, and from 17 to 50,7 for the siblings. Unlike parents, siblings generally attended a limited number of sessions. Image: Image 2: Image 3: Conclusions This descriptive study reflects the work carried out with 18 patients and their relatives in an MFT group providing psychoeducation to patients suffering from schizophrenia and their caregivers. 50 persons benefited from psychoeducation in 2 years. We learned from these results to improve the constitution of our groups and the benefits of our psychoeducation program. We were careful to include families with siblings as we know they are affected by the mental illness in the family and are often left aside of all care/support proposals. We questioned ourselves on the advantages of homogeneous or heterogeneous groups, considering age, history of follow up. How could it impact affiliation to the group or differentiation movements ? How useful or harmful it is for sharing experiences between the families. A proper study would be necessary to answer these questions. Disclosure of Interest None Declared
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- 2024
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32. Comprehensive analysis of brain injury parameters in a preclinical porcine model of acute liver failure
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Philipp Felgendreff, Seyed M. Hosseiniasl, Lisa Felgendreff, Bruce P. Amiot, Anna Minshew, Boyukkhanim Ahmadzada, Zhi Qu, Silvana Wilken, Ines Arribas Gomez, Scott L. Nyberg, and Casey N. Cook
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brain injury ,acute liver failure ,serum parameter ,porcine model ,GFAP ,Medicine (General) ,R5-920 - Abstract
IntroductionAcute liver failure (ALF) is defined as acute loss of liver function leading to hepatic encephalopathy associated with a high risk of patient death. Brain injury markers in serum and tissue can help detect and monitor ALF-associated brain injury. This study compares different brain injury parameters in plasma and tissue along with the progression of ALF.MethodALF was induced by performing an 85% liver resection. Following the resection, animals were recovered and monitored for up to 48 h or until reaching the predefined endpoint of receiving standard medical therapy (SMT). Blood and serum samples were taken at Tbaseline, T24, and upon reaching the endpoint (Tend). Control animals were euthanized by exsanguination following plasma sampling. Postmortem brain tissue samples were collected from the frontal cortex (FCTx) and cerebellum (Cb) of all animals. Glial fibrillary acidic protein (GFAP) and tau protein and mRNA levels were quantified using ELISA and qRT-PCR in all plasma and brain samples. Plasma neurofilament light (NFL) was also measured using ELISA.ResultsAll ALF animals (n = 4) were euthanized upon showing signs of brain herniation. Evaluation of brain injury biomarkers revealed that GFAP was elevated in ALF animals at T24h and Tend, while Tau and NFL concentrations were unchanged. Moreover, plasma glial fibrillary acidic protein (GFAP) levels were negatively correlated with total protein and positively correlated with both aspartate transaminase (AST) and alkaline phosphatase (AP). Additionally, lower GFAP and tau RNA expressions were observed in the FCTx of the ALF group but not in the CB tissue.ConclusionThe current large animal study has identified a strong correlation between GFAP concentration in the blood and markers of ALF. Additionally, the protein and gene expression analyses in the FCTx revealed that this area appears to be susceptible, while the CB is protected from the detrimental impacts of ALF-associated brain swelling. These results warrant further studies to investigate the mechanisms behind this process.
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- 2024
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33. A novel prognostic scoring system combining the revised Tokuhashi score and the New England spinal metastasis score for preoperative evaluation of spinal metastases
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Dionisia Mavritsakis and Louis-Philippe Amiot
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Tokuhashi ,spine ,orthopedic surgery ,NESMS ,score ,Surgery ,RD1-811 - Abstract
PurposeNumerous scoring systems have been developed in order to determine the prognosis of spinal metastases. Predicting as accurately as possible the life expectancy of patients with spinal metastatic disease is very important, as it's the decisive factor in selecting the optimal treatment for the patient. The Revised Tokuhashi score (RTS) and the New England Spinal Metastasis score (NESMS) are popular scoring systems used to determine the optimal treatment modality. However, they sometimes provide conflicting results. We propose a novel prognostic scoring system, which combines the RTS and NESMS scores in order to predict with greater accuracy the prognosis.MethodsWe retrospectively reviewed the data of 64 patients with spinal metastasis enrolled between 2012 and 2021 in the Department of Orthopedic Surgery-Spine, Hôpital Maisonneuve-Rosemont, Montréal, Que. The new score per patient was calculated as a combination of the RTS of each patient and the patient's corresponding NESMS. The new score was then compared to the actual patient survival period and divided into 3 categories: Low, Moderate and Good prognosis. We then compared the accuracy of our new score to RTS.ResultsIn the Low Prognosis group, the reliability of predicting the prognosis was 51.9% in 27 patients. In the Moderate Prognosis group, the reliability of predicting the prognosis was 95.8% in 24 patients. In the Good Prognosis group, the reliability of predicting the prognosis was 100% in 13 patients. Our new score was found more accurate than RTS as the R2 parameter corresponding to the new score was significantly increased compared to the same parameter corresponding to the RTS score indicating a higher percentage of survival predictability for the new score as compared to the RTS score.ConclusionThis study demonstrates that a new prognostic scoring system, which would combine the RTS and the NESMS, is promising in providing an improved accuracy for predicting the actual patient survival, especially for the moderate and good prognosis patients. An appropriate prospective investigation with a larger sample size should be conducted in order to further investigate the validity of this novel scoring system and its overall predictive value.
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- 2024
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34. Memory effects in friction: the role of sliding heterogeneities
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Fazio, vincenzo, Acito, Vito, Amiot, Fabien, Frétigny, Christian, and Chateauminois, Antoine
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Condensed Matter - Soft Condensed Matter - Abstract
We report on memory effects involved in the transient frictional response of a contact interface between a silicone rubber and a spherical glass probe when it is perturbed by changes in the orientation of the driving motion or by velocity steps. From measurements of the displacement fields at the interface, we show that observed memory effects can be accounted for by the non-uniform distribution of the sliding velocity within the contact interface. As a consequence of these memory effects, the friction force may no longer be aligned with respect to the sliding trajectory. In addition, stick-slip motions with a purely geometrical origin are also evidenced. These observations are adequately accounted for by a friction model which takes into account heterogeneous displacements within the contact area. When a velocity dependence of the frictional stress is incorporated in this the model, transient regimes induced by velocity steps are also adequately described. The good agreement between the model and experiments outlines the role of space heterogeneities in memory effects involved in soft matter friction.
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- 2021
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35. Indecomposable objects in the derived category of a skew-gentle algebra using orbifolds
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Amiot, Claire
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Mathematics - Representation Theory - Abstract
Skew-gentle algebras are skew-group algebras of certain gentle algebras endowed with a Z 2-action. Using the topological description of Opper, Plamondon and Schroll in [OPS] for the indecomposable objects of the derived category of any gentle algebra, one obtains here a complete description of indecomposable objects in the derived category of any skew-gentle algebras in terms of curves on an orbifold surface.The results presented here are complementary to the ones in [LSV]. First, we obtain a complete classification of indecomposable objects and not of ''homotopy strings'' and ''homotopy bands'' which are not always indecomposable. Second, the classification obtained here does not use the combinatorial description of [BMM03], but topological arguments coming from the double cover of the orbifold surface constructed in [AB]., Comment: To be published in the Proceedings of ICRA2020
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- 2021
36. Exploring the role of our contacts with pets in broadening concerns for animals, nature, and fellow humans: a representative study
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Catherine E. Amiot, Christophe Gagné, and Brock Bastian
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Medicine ,Science - Abstract
Abstract While pet ownership is normative in many occidental countries, whether humans’ proximal contacts with pets have implications for attitudes and behaviors toward other (non pet) animals, nature, and fellow humans, has received limited empirical attention. In a large representative sample, we investigate whether pet ownership and positive contact with pets are associated with more positive attitudes and heightened concerns for non-pet animals, nature, and human outgroups. A cross-sectional questionnaire survey was conducted among Canadian adults (619 pet owners, 450 non-pet owners). Pet owners reported more positive attitudes toward non-pet animals (e.g., wild, farm animals), higher identification with animals, more positive attitudes toward human outgroups, higher biospheric environmental concerns, higher human–environment interdependence beliefs, and lower usual meat consumption. Positive contact with pets was also associated with most of these outcomes. Solidarity with animals, a dimension of identification with animals, emerged as a particularly clear predictor of these outcomes and mediated the associations between positive contact with pets and positive attitudes toward non-pet animals, biospheric, egoistic, and altruistic environmental concerns, human–environment interdependence beliefs, and diet. Our results provide support for the capacity of pets to shape human consideration for a broad range of social issues, beyond the specific context of human-pet relations.
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- 2023
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37. Short-Term Effect of Bariatric Surgery on Cardiorespiratory Response at Submaximal, Ventilatory Threshold, and Maximal Exercise in Women with Severe Obesity
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Vibarel-Rebot, Nancy, Asselin, Marine, Amiot, Virgile, and Collomp, Katia
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- 2023
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38. Nutritional optimization through linear programming of climate-smart and gluten free pasta
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Pinel, P., Drogue, S., Amiot-Carlin, M.J., Vannier, C., Bourlieu-Lacanal, C., and Micard, V.
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- 2024
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39. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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Zwirner, Stefan, Abu Rmilah, Anan A., Klotz, Sabrina, Pfaffenroth, Bent, Kloevekorn, Philip, Moschopoulou, Athina A., Schuette, Svenja, Haag, Mathias, Selig, Roland, Li, Kewei, Zhou, Wei, Nelson, Erek, Poso, Antti, Chen, Harvey, Amiot, Bruce, Jia, Yao, Minshew, Anna, Michalak, Gregory, Cui, Wei, Rist, Elke, Longerich, Thomas, Jung, Birgit, Felgendreff, Philipp, Trompak, Omelyan, Premsrirut, Prem K., Gries, Katharina, Muerdter, Thomas E., Heinkele, Georg, Wuestefeld, Torsten, Shapiro, David, Weissbach, Markus, Koenigsrainer, Alfred, Sipos, Bence, AB, Eiso, Zacarias, Magdalena Ortiz, Theisgen, Stephan, Gruenheit, Nicole, Biskup, Saskia, Schwab, Matthias, Albrecht, Wolfgang, Laufer, Stefan, Nyberg, Scott, and Zender, Lars
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- 2024
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40. A p53 score derived from TP53 CRISPR/Cas9 HMCLs predicts survival and reveals a major role of BAX in the response to BH3 mimetics
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Durand, Romane, Descamps, Géraldine, Bellanger, Céline, Dousset, Christelle, Maïga, Sophie, Alberge, Jean-Baptiste, Derrien, Jennifer, Cruard, Jonathan, Minvielle, Stéphane, Lilli, Nicoletta Libera, Godon, Catherine, Le Bris, Yannick, Tessoulin, Benoit, Amiot, Martine, Gomez-Bougie, Patricia, Touzeau, Cyrille, Moreau, Philippe, Chiron, David, Moreau-Aubry, Agnès, and Pellat-Deceunynck, Catherine
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- 2024
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41. Regional heterothermies recorded in the oxygen isotope composition of harbour seal skeletal elements
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Séon, Nicolas, Amiot, Romain, Suan, Guillaume, Lécuyer, Christophe, Fourel, François, Vinçon-Laugier, Arnauld, Charbonnier, Sylvain, and Vincent, Peggy
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- 2024
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42. First Application of a Mixed Porcine–Human Repopulated Bioengineered Liver in a Preclinical Model of Post-Resection Liver Failure
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Philipp Felgendreff, Seyed Mohammad Hosseiniasl, Anna Minshew, Bruce P. Amiot, Silvana Wilken, Boyukkhanim Ahmadzada, Robert C. Huebert, Nidhi Jalan Sakrikar, Noah G. Engles, Peggy Halsten, Kendra Mariakis, John Barry, Shawn Riesgraf, Chris Fecteau, Jeffrey J. Ross, and Scott L. Nyberg
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tissue engineering ,acute liver failure ,extracorporeal liver assist device ,Biology (General) ,QH301-705.5 - Abstract
In this study, a mixed porcine–human bioengineered liver (MPH-BEL) was used in a preclinical setup of extracorporeal liver support devices as a treatment for a model of post-resection liver failure (PRLF). The potential for human clinical application is further illustrated by comparing the functional capacity of MPH-BEL grafts as assessed using this porcine PRLF model with fully human (FH-BEL) grafts which were perfused and assessed in vitro. BEL grafts were produced by reseeding liver scaffolds with HUVEC and primary porcine hepatocytes (MPH-BEL) or primary human hepatocytes (FH-BEL). PRLF was induced by performing an 85% liver resection in domestic white pigs and randomized into the following three groups 24 h after resection: standard medical therapy (SMT) alone, SMT + extracorporeal circuit (ECC), and SMT + MPH-BEL. The detoxification and metabolic functions of the MPH-BEL grafts were compared to FH-BEL grafts which were perfused in vitro. During the 24 h treatment interval, INR values normalized within 18 h in the MPH-BEL therapy group and urea synthesis increased as compared to the SMT and SMT + ECC control groups. The MPH-BEL treatment was associated with more rapid decline in hematocrit and platelet count compared to both control groups. Histological analysis demonstrated platelet sequestration in the MPH-BEL grafts, possibly related to immune activation. Significantly higher rates of ammonia clearance and metabolic function were observed in the FH-BEL grafts perfused in vitro than in the MPH-BEL grafts. The MPH-BEL treatment was associated with improved markers of liver function in PRLF. Further improvement in liver function in the BEL grafts was observed by seeding the biomatrix with human hepatocytes. Methods to reduce platelet sequestration within BEL grafts is an area of ongoing research.
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- 2024
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43. Fully Automatic Grading of Retinal Vasculitis on Fluorescein Angiography Time-lapse from Real-world Data in Clinical Settings.
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Victor Amiot, Oscar Alfonso Jiménez del Toro, Pauline Eyraud, Yan Guex-Crosier, Ciara Bergin, André Anjos, Florence Hoogewoud, and Mattia Tomasoni
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- 2023
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44. On The Need of a New High-Resolution L-Band Mission to Study Land/Water/Ice Interfaces.
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Nemesio Rodriguez-Fernandez, Jacqueline Boutin, Lars Kaleschke, Gabrielle De Lannoy, Giovanni Macelloni, Kimmo Rautiainen, Maria José Escorihuela, Peter Weston, Patricia de Rosnay, Jean-Christophe Calvet, Frédéric Frappart, Alexandre Roy, Thierry Pellarin, Andreas Colliander, Alexandre Supply, Eric Anterrieu, Philippe Richaume, Arnaud Mialon, Cécile Cheymol, Thierry Amiot, Louise Yu, Manuel Martín-Neira, Asma Kallel, Benjamin Carayon, Josep Closa, Alberto Zurita, and Yann Kerr
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- 2023
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45. A New High Spatial Resolution Interferometric Radiometer for L-Band Earth Observation.
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Asma Kallel, Thibaut Decoopman, Benjamin Carayon, Laurent Costes, Jean-Claude Orlhac, Nicolas Jeannin, Thierry Amiot, Cécile Cheymol, Louise Yu, Raquel Rodriguez-Suquet, Patrice Gonzalez, Aurélie Bornot, Nemesio Rodriguez-Fernandez, Eric Anterrieu, and Yann H. Kerr
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- 2023
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46. Gastric microbiota in patients with gastric MALT lymphoma according to Helicobacter pylori infection
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Martin, Antoine, Jauvain, Marine, Bergsten, Emma, Demontant, Vanessa, Lehours, Philippe, Barau, Caroline, Levy, Michael, Rodriguez, Christophe, Sobhani, Iradj, and Amiot, Aurelien
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- 2024
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47. The monoaminergic system is a bilaterian innovation
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Matthew Goulty, Gaelle Botton-Amiot, Ezio Rosato, Simon G. Sprecher, and Roberto Feuda
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Science - Abstract
Abstract Monoamines like serotonin, dopamine, and adrenaline/noradrenaline (epinephrine/norepinephrine) act as neuromodulators in the nervous system. They play a role in complex behaviours, cognitive functions such as learning and memory formation, as well as fundamental homeostatic processes such as sleep and feeding. However, the evolutionary origin of the genes required for monoaminergic modulation is uncertain. Using a phylogenomic approach, in this study, we show that most of the genes involved in monoamine production, modulation, and reception originated in the bilaterian stem group. This suggests that the monoaminergic system is a bilaterian novelty and that its evolution may have contributed to the Cambrian diversification.
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- 2023
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48. Clinical characterization of a hypersensitivity mixed bacterial and fungal dermatitis in a translational model of porcine NASH
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Philipp Felgendreff, Josephine M. Lawrence, Seyed M. Hosseiniasl, Julie F. Jacobs, Bruce P. Amiot, Lisa Felgendreff, Anna Minshew, Ahmer Sultan, Boyukkhanim Ahmadzada, Michael C. Rahe, and Scott L. Nyberg
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NASH ,skin evaluation system ,large animal model ,microbiome ,dermatitis ,Microbiology ,QR1-502 - Abstract
IntroductionThe development of animal models of chronic liver disease via diet modification is a promising avenue for translational research but can lead to unexpected side effects that impact model adoption. While these side effects are well characterized in rodent models of nonalcoholic steatohepatitis (NASH), limited knowledge of these effects exists for novel porcine models of NASH. To close this gap, the present study investigates the side effects of diet-based NASH induction in pigs, with a systematic analysis of the pathologic mechanisms underlying dermatitis development and evaluation of treatment approaches.MethodTwelve pigs (10 large domestic pigs, 2 Goettingen minipigs) were fed a methionine- and choline-deficient, high-fat diet for 8 weeks to induce NASH. A retrospective review of each animal’s clinical record was performed to identify the side effects of the diet. Following the identification of diet-associated dermatitis, severity was judged by using a novel gradation system that characterized the individual lesions and body regions resulting in a cumulative evaluation. In addition to this clinical assessment, the etiology of the dermatitis was investigated via histopathologic and microbiologic testing. Furthermore, the success of prophylactic and therapeutic treatment approaches was evaluated by considering dermatitis development and clinical course.ResultsAll study animals demonstrated unexpected side effects of the methionine- and choline-deficient, high fat diet. In addition to marked dermatitis, study pigs showed impaired weight gain and developed steatorrhea and anemia. Based on the skin gradation system, five animals developed severe dermatitis, four animals moderate dermatitis, and three animals mild diet-associated dermatitis. Histological and microbiological evaluation of the affected skin showed signs of a hypersensitivity reaction with secondary infection by bacteria and fungi. The analysis showed that preemptive bathing extended the lesion-free duration by nearly 20 days. Furthermore, bathing in combination with a targeted antibiotic treatment represented a helpful treatment approach for diet-associated dermatitis.ConclusionThe provision of a methionine- and choline-deficient, high fat diet represents an effective approach for inducing NASH liver disease in pigs but predisposes study animals to multiple side effects. These side effects are universal to animals on study but can be adequately managed and do not represent a significant limitation of this model.
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- 2024
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49. Computational spectral-domain single-pixel imaging
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Ryczkowski, Piotr, Amiot, Caroline, Dudley, John M., and Genty, Goery
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Physics - Optics ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
We demonstrate single-pixel imaging in the spectral domain by encoding Fourier probe patterns onto the spectrum of a superluminescent laser diode using a programmable optical filter. As a proof-of-concept, we measure the wavelength-dependent transmission of a Michelson interferometer and a wavelength-division multiplexer. Our results open new perspectives for remote broadband measurements with possible applications in industrial, biological or security applications.
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- 2020
50. Evaluación de la disfunción del endotelio para el pronóstico de riesgo cardiovascular
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Tania Delia Carbonell Amiot, Liudmila Risset Castro Andión, and Ana Lubín García
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enfermedades cardiovasculares ,factores de riesgo ,endotelio vascular ,predicción de riesgos. ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Introducción: Las enfermedades cardiovasculares constituyen la primera causa de muerte en el mundo, por lo que la identificación y modificación de los factores de riesgo asociados a ellas constituyen estrategias priorizadas por la Organización Mundial de la Salud. Contar con un modelo de predicción del riesgo cardiovascular enriquecido con la evaluación de la disfunción endotelial influiría positivamente en estas metas. Objetivos: Identificar la presencia de disfunción endotelial en pacientes con enfermedades cardiovasculares o sin estas y determinar la asociación entre ambas. Métodos: Se realizó un estudio observacional y descriptivo, de serie de casos, en el Centro de Cardiología y Cirugía Cardiovascular del Hospital Provincial Docente Clínico-Quirúrgico Saturnino Lora de Santiago de Cuba, desde enero del 2022 hasta igual mes del 2023, donde se analizaron como variables los factores de riesgo cardiovascular tradicionales y los biomarcadores de disfunción endotelial. Secundariamente, se llevó a cabo un estudio analítico de casos y controles en el cual se aplicó la regresión logística binaria multivariada. Resultados: Se confirmó la presencia de disfunción endotelial asociada a la aparición de las enfermedades cardiovasculares, lo que se evaluó a través del índice de vasodilatación, mediado por el flujo de la arteria braquial y las concentraciones plasmáticas de fibrinógeno. Conclusiones: Las características epidemiológicas y clínicas de los pacientes con enfermedades cardiovasculares o sin estas no difirieron de lo registrado en la literatura especializada acerca de la base de identificación de los factores de riesgo tradicionales.
- Published
- 2023
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